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University of Manitoba
1.
Aktar, Amena.
PlexinD1 deficiency in macrophage exacerbates house dust mite-induced allergic asthma.
Degree: Immunology, 2019, University of Manitoba
URL: http://hdl.handle.net/1993/34451
► Semaphorin3E (Sema3E) and its receptor plexinD1 are involved in cell migration, proliferation, and angiogenesis considered key features of asthma. The absence of Sema3E exacerbates asthma…
(more)
▼ Semaphorin3E (Sema3E) and its receptor plexinD1 are involved in cell migration, proliferation, and angiogenesis considered key features of
asthma. The absence of Sema3E exacerbates
asthma features, and treatment with recombinant Sema3E reduces inflammation and airway hyperresponsiveness (AHR). However, whether Sema3E-plexinD1 axis regulates airway macrophages function in allergic
asthma has not been studied. Therefore, we investigated the role of plexinD1 deficient macrophage in allergic
asthma. Genetic ablation of plexinD1 receptor in interstitial macrophages was performed in vivo by crossing CX3CR1Cre/ERT with Plxnd1 floxed mice followed by tamoxifen treatment. AHR, airway inflammation and remodeling were measured by flexivent, flow cytometry, histochemistry, ELISA, and RT-PCR techniques respectively. We found that the absence of Plxnd1 in lung interstitial macrophages increased AHR, airway leukocytes number, allergen-specific IgE, goblet cell hyperplasia, and Th2/Th17 cytokines response in the acute house dust mite model of allergic
asthma. Also, the expression of Muc5ac, Muc5b and α-SMA genes were increased in mice with Plxnd1 deficient interstitial macrophage compared to WT mice.
Our data suggest that lung interstitial macrophage via Sema3E/plexinD1 axis negatively regulates airway inflammation, AHR, and airway remodeling in a murine model of allergic
asthma.
Advisors/Committee Members: Soussi Gounni, Abdelilah (Immunology) (supervisor), Fowke, Keith (Medical Microbiology and Infectious Diseases) Mookherjee, Neeloffer (Internal Medicine) Murooka, Thomas (Immunology) (examiningcommittee).
Subjects/Keywords: Asthma
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APA (6th Edition):
Aktar, A. (2019). PlexinD1 deficiency in macrophage exacerbates house dust mite-induced allergic asthma. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/34451
Chicago Manual of Style (16th Edition):
Aktar, Amena. “PlexinD1 deficiency in macrophage exacerbates house dust mite-induced allergic asthma.” 2019. Masters Thesis, University of Manitoba. Accessed January 18, 2021.
http://hdl.handle.net/1993/34451.
MLA Handbook (7th Edition):
Aktar, Amena. “PlexinD1 deficiency in macrophage exacerbates house dust mite-induced allergic asthma.” 2019. Web. 18 Jan 2021.
Vancouver:
Aktar A. PlexinD1 deficiency in macrophage exacerbates house dust mite-induced allergic asthma. [Internet] [Masters thesis]. University of Manitoba; 2019. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1993/34451.
Council of Science Editors:
Aktar A. PlexinD1 deficiency in macrophage exacerbates house dust mite-induced allergic asthma. [Masters Thesis]. University of Manitoba; 2019. Available from: http://hdl.handle.net/1993/34451

University of Hawaii – Manoa
2.
Jessop, Holly.
Asthma health disparities among Native Hawaiians and other Pacific Islander adults of the United States, 2001-2009.
Degree: 2016, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/101584
► M.S. University of Hawaii at Manoa 2011.
Elimination of health disparities is a public health priority. Asthma is a serious and often debilitating health condition,…
(more)
▼ M.S. University of Hawaii at Manoa 2011.
Elimination of health disparities is a public health priority. Asthma is a serious and often debilitating health condition, with well-documented racial disparities in prevalence. Because asthma is a substantial health problem, with markedly increasing prevalence and mortality rates, there is an urgent need to adequately characterize asthma in high-risk populations such as Native Hawaiians and other Pacific Islanders (NHOPI) who may be disproportionately affected. However, little is known about the burden of asthma in NHOPI compared to other races in the United States (U.S.). This study is an investigation of the prevalence of asthma amongst NHOPI within the U.S., using nine years of data (2001-2009) from complete telephone survey responses of the Behavioral Risk Factor Surveillance System. Crude lifetime weighted asthma prevalence was significantly greater in NHOPI (17.22%; 95% confidence interval [CI]: 15.36, 19.25%) than in Whites (12.49%; 95% CI: 12.40%, 12.57%), and the NHOPI asthma prevalence point estimates were higher than in Whites in all age, sex, education, health care coverage, smoking status, body mass index, place of residence (Hawaiʻi vs. Mainland U.S.), and time period strata examined. Regardless of race, younger age (especially 18-24 years), female sex, education attainment less than a college degree, smoking, overweight/obese body mass index, residence in the State of Hawaiʻi, and later time periods (i.e., 2004-2006 and 2007-2009 vs. 2001-2003) were all independently associated with asthma. After controlling for these socio-demographic, geographic, and temporal factors, NHOPI odds of asthma remained significantly greater than for Whites (odds ratio [OR] 1.33; 95% CI: 1.16, 153). While adjusted odds of asthma increased with time overall (1.16; 95% CI: 1.14, 1.18 for 2007-2009 vs. 2001-2003), adjusted odds of asthma
Subjects/Keywords: asthma
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APA (6th Edition):
Jessop, H. (2016). Asthma health disparities among Native Hawaiians and other Pacific Islander adults of the United States, 2001-2009. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101584
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Jessop, Holly. “Asthma health disparities among Native Hawaiians and other Pacific Islander adults of the United States, 2001-2009.” 2016. Thesis, University of Hawaii – Manoa. Accessed January 18, 2021.
http://hdl.handle.net/10125/101584.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Jessop, Holly. “Asthma health disparities among Native Hawaiians and other Pacific Islander adults of the United States, 2001-2009.” 2016. Web. 18 Jan 2021.
Vancouver:
Jessop H. Asthma health disparities among Native Hawaiians and other Pacific Islander adults of the United States, 2001-2009. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10125/101584.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Jessop H. Asthma health disparities among Native Hawaiians and other Pacific Islander adults of the United States, 2001-2009. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101584
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen
3.
Varga, Fruzsina.
Foglalkozási asthma
.
Degree: DE – OEC – Általános Orvostudományi Kar, 2013, University of Debrecen
URL: http://hdl.handle.net/2437/169390
► A foglalkozási asthma az extrinsic asthma bronchiale olyan variánsa, amelyet a munkahelyen tartósan, nagy mennyiségben jelenlévő anyagok, vagyis expozíciók belégzése indukál. A megbetegedés eredményeként a…
(more)
▼ A foglalkozási
asthma az extrinsic
asthma bronchiale olyan variánsa, amelyet a munkahelyen tartósan, nagy mennyiségben jelenlévő anyagok, vagyis expozíciók belégzése indukál. A megbetegedés eredményeként a levegő áramlása csökken a légutakban. Az asthmát kiváltani képes kóroki tényezők közé ma már több mint 200 anyagot sorolhatunk, melyek két csoportot alkotnak. Az egyik csoport a nagy molekulatömegű fehérjetermészetű anyagok csoportja. A másik csoport a kis molekulatömegű kémiai anyagokat foglalja magába. Munkahelyi allergének közül kiemelhetők a szerves oldószerek (pl. izocianátok), a fémek (nikkel, platinasók), állati (laboratóriumi állatok vizelete, szőre) és növényi eredetű (gabonapor, liszt) anyagok.
A diplomamunka célkitűzése volt, hogy összefoglaló képet adjon a foglalkozási
asthma magyarországi állapotáról.
A munka irodalmi összefoglaló. A diplomamunkában szereplő hazai gyakorisági adatokat az Országos Munkahigénés és Foglalkozás-egészségügyi Intézetbe (OMFI) és a Shield programba bejelentett esetekből összegeztem 1998 és 2003 közötti időszakra vonatkozólag és hasonlítottam össze Nagy-Britannia értékeivel.
Az adatok időbeni változását elemezve egyértelműen leolvasható, hogy ha nem is egyenletes mértékben, de csökken a foglalkozási
asthma előfordulása Magyarországon és Nagy-Britanniában is.
Mivel a foglalkozási asthmát könnyebb megelőzni, mint kezelni, ezért nagy jelentőséget kell fordítanunk a munkahelyi prevencióra. Primer prevenció során az egyéni és környezeti faktoroknak való kitettség csökkentése a cél. Ezen célra használjuk fel pl. a zárt technológiát, az elszívó berendezéseket. A secunder prevenció célja a preklinikai elváltozások azonosítása előzetes és időszakos alkalmassági vizsgálatok során. Tercier prevenció a betegség minél hamarabbi kezelését és a beteg allergén expozícióból történő eltávolítását foglalja magába a szövődmények és a súlyosbodás elkerülése érdekében.
A foglalkozási asthmások számának a vizsgált időszakban bekövetkező csökkenése remélhetőleg legalább részben a hatékony prevenciónak köszönhető.
Advisors/Committee Members: Ádám, Balázs (advisor), Debreceni Egyetem::Orvos- és Egészségtudományi Centrum (advisor).
Subjects/Keywords: foglalkozási asthma;
asthma
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Varga, F. (2013). Foglalkozási asthma
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/169390
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Varga, Fruzsina. “Foglalkozási asthma
.” 2013. Thesis, University of Debrecen. Accessed January 18, 2021.
http://hdl.handle.net/2437/169390.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Varga, Fruzsina. “Foglalkozási asthma
.” 2013. Web. 18 Jan 2021.
Vancouver:
Varga F. Foglalkozási asthma
. [Internet] [Thesis]. University of Debrecen; 2013. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/2437/169390.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Varga F. Foglalkozási asthma
. [Thesis]. University of Debrecen; 2013. Available from: http://hdl.handle.net/2437/169390
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hawaii – Manoa
4.
Miguel, Luzviminda.
Ka‘u Community Asthma Management Program.
Degree: 2017, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/51273
► D.N.P. University of Hawaii at Manoa 2016.
Asthma has debilitating effects which impact the mental, physical and socio-economic aspects of the population. The Ka’u district…
(more)
▼ D.N.P. University of Hawaii at Manoa 2016.
Asthma has debilitating effects which impact the mental, physical and socio-economic aspects of the population. The Ka’u district has the highest number of adults who have asthma. The project was guided by the ACE Star Model of Knowledge Transformation complimented by community participatory approach. Literature review and synthesis revealed that community-based asthma education and asthma self-management that includes self-efficacy, an asthma action plan, journal writing, and the use of peak flow meters are the most effective interventions for asthma control. The objective of the project was to determine whether community-based asthma education and self-management including: self-efficacy, an asthma action plan, journal writing, and use of peak flow meters, reduces asthma exacerbations.
The Ka’u Community Asthma Management Program (KCAMP) is an evidence-based practice project designed to improve the practice of management of asthma. One-on-one and group asthma educational teaching and skills training sessions were provided to participants. The program sessions were held in Naʻālehu, Hawai’i at Hui Mālama Ola Nā ‛Ōiwi, at the Hawai’i County Economic Opportunity Council Center, and in the residences of the participants.
Fourteen adult residents with asthma from the Ka’u District, ages from 28 to 75 years old participated in the program. There were 64% (n=9) females and 36% (n=5) males. The racially diverse group included ten Hawaiians, three Asians, and one Caucasian.
Participation in the program resulted in the increase of asthma knowledge 93% (n=13); ACT scores increased by 100% (n=14); MiniAQLQ scores increased by 93% (n=13); peak flow measurements increased by 86% (n=12); FEV1 levels increased by 64% (n=9); and, 71% (n=10) choosing asthma education as the most helpful intervention.
This project increased participants’ knowledge in asthma, decreased asthma exacerbations, prevented hospitalization, provided participants confidence to manage their asthma and increased their quality of life. The key implication for practice is to promote KCAMP as a community based asthma self-management program. The barriers and challenges of the project serve as exemplars for others the incentive to create plans to overcome these obstacles. This project serves as a form of asthma self-management program in the community setting.
Subjects/Keywords: Asthma; Asthma Management; Asthma and Community
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Miguel, L. (2017). Ka‘u Community Asthma Management Program. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/51273
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Miguel, Luzviminda. “Ka‘u Community Asthma Management Program.” 2017. Thesis, University of Hawaii – Manoa. Accessed January 18, 2021.
http://hdl.handle.net/10125/51273.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Miguel, Luzviminda. “Ka‘u Community Asthma Management Program.” 2017. Web. 18 Jan 2021.
Vancouver:
Miguel L. Ka‘u Community Asthma Management Program. [Internet] [Thesis]. University of Hawaii – Manoa; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10125/51273.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Miguel L. Ka‘u Community Asthma Management Program. [Thesis]. University of Hawaii – Manoa; 2017. Available from: http://hdl.handle.net/10125/51273
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Mehta, Amit Kumar.
Evaluation of choline as an anti- inflammatory agent for
the treatment of asthma.
Degree: 2009, University of Pune
URL: http://shodhganga.inflibnet.ac.in/handle/10603/2545
► Asthma is a chronic immune inflammatory disease characterized by variable airflow obstruction and increased bronchial hyperreactivity (BHR). Inflammation is the hallmark of asthma and allergic…
(more)
▼ Asthma is a chronic immune inflammatory disease
characterized by variable airflow obstruction and increased
bronchial hyperreactivity (BHR). Inflammation is the hallmark of
asthma and allergic disorders. The incidence of asthma has
increased world over, which presents both public health and
economic concerns. Asthma results from constriction or narrowing of
bronchial tube caused by muscle spasm and airway narrowing due to
immune inflammation. Efforts are therefore required to find out
appropriate anti-inflammatory drug with no or minimal side-effect
for management of the disease. The current asthma therapy is given
to control symptoms such as coughing, wheezing, and or shortness of
breath. However, the medications do not relieve the underlying
inflammatory process of asthma completely. Inhaled
glucocorticosteroids are at present the most effective controller
medications. But controlled clinical trials have demonstrated that
long-term treatment with high doses of inhaled glucocorticosteroids
may be associated with systemic side-effects, including skin
thinning and easy bruising, adrenal suppression and decreased bone
mineral density. Choline, as a lipotropic factor is needed for
maintaining cell structure and to facilitate the movement of fats
in and out of cells. Choline, the major constituent of
phosphatidylcholine (PC), is found in soybean, liver, oatmeal,
cabbage and cauliflower. Previous studies with choline showed
anti-inflammatory activity in arthritis animal model. But, whether
choline had anti-inflammatory activity in the airways remains to be
investigated. The present study (chapter 2) aims to evaluate the
anti-inflammatory activity of choline in mouse model of allergic
airway inflammation. Choline (1 mg/kg) was administered via oral
gavage or intranasal (i.n.) route before and after ovalbumin (OVA)
challenge in sensitized mice. Airway hyperresponsiveness (AHR) to
methacholine was measured in mice by whole body
plethysmography.
References p. 141-180, appendix p.
181-184
Advisors/Committee Members: Singh, Bhanu Pratap.
Subjects/Keywords: Biotechnology; Asthma; Asthma treatment
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mehta, A. K. (2009). Evaluation of choline as an anti- inflammatory agent for
the treatment of asthma. (Thesis). University of Pune. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/2545
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mehta, Amit Kumar. “Evaluation of choline as an anti- inflammatory agent for
the treatment of asthma.” 2009. Thesis, University of Pune. Accessed January 18, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/2545.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mehta, Amit Kumar. “Evaluation of choline as an anti- inflammatory agent for
the treatment of asthma.” 2009. Web. 18 Jan 2021.
Vancouver:
Mehta AK. Evaluation of choline as an anti- inflammatory agent for
the treatment of asthma. [Internet] [Thesis]. University of Pune; 2009. [cited 2021 Jan 18].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2545.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mehta AK. Evaluation of choline as an anti- inflammatory agent for
the treatment of asthma. [Thesis]. University of Pune; 2009. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2545
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Banasiak, Nancy.
Implementation of the Asthma Control Test in Primary Care to Improve Patient Outcomes.
Degree: 2018, The Catholic University of America
URL: http://hdl.handle.net/1961/cuislandora:72124
► Background: Asthma is one of the major chronic diseases in the pediatric population affecting 9.5% of children. The National Heart, Lung, and Blood Institute (NHLBI)…
(more)
▼ Background: Asthma is one of the major chronic diseases in the pediatric population affecting 9.5% of children. The National Heart, Lung, and Blood Institute (NHLBI) recommends the use of the Childhood-Asthma Control Test or the Asthma Control Test for periodic assessment of asthma control as one of the four validated instruments. Despite the recommendation from the national guidelines, research has shown adherence to the guidelines is suboptimal.Purpose: The purpose of this evidence-based project was to implement the Childhood-Asthma Control Test or the Asthma Control Test screening tools into the primary care practice to improve management of patients with asthma by more accurately addressing asthma control. The anticipated outcomes of this project were improved identification of asthma control from the patient and/or family’s perspective in accordance with the national guidelines and optimization of asthma management based upon the level of control.Methods: The Iowa Model-Revised: Evidence-Based Practice to Promote Excellence in Health Care was used to guide this evidence-based project. An educational program was devised and presented to the providers and nursing staff of the clinic. A systematic change was implemented. The project was a pre and post implementation study comparing two different groups of patients with asthma seen at the clinic over five-week periods.Results: Prior to implementation, only 1 APRN had used a single Asthma Control Test. After the implementation of the educational program and project, 82.6% of APRNs and 30.7% of pediatric resident physicians utilized an Asthma Control Test resulting in identification of 9 (21%) patients who were considered not well-controlled. All (100%) of those children identified as not well-controlled through the Asthma Control Test received an adjustment in their medication therapy and one child was referred to pulmonary medicine for further evaluation. Conclusion: The C-ACT and ACT are simple, self-administered, validated questionnaires that can easily be incorporated into a primary care practice to assess the level of asthma control and to identify patients with asthma that is not well controlled.
Nursing
Asthma, Asthma Control Test, Pediatrics
Nursing
Degree Awarded: D.N.P. Nursing. The Catholic University of America
Advisors/Committee Members: The Catholic University of America (Degree granting institution), Hawkins-Walsh, Elizabeth (Thesis advisor), Harrow, Cheryl (Committee member), Meadows-Oliver, Mikki (Committee member).
Subjects/Keywords: Asthma; Asthma Control Test; Pediatrics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Banasiak, N. (2018). Implementation of the Asthma Control Test in Primary Care to Improve Patient Outcomes. (Thesis). The Catholic University of America. Retrieved from http://hdl.handle.net/1961/cuislandora:72124
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Banasiak, Nancy. “Implementation of the Asthma Control Test in Primary Care to Improve Patient Outcomes.” 2018. Thesis, The Catholic University of America. Accessed January 18, 2021.
http://hdl.handle.net/1961/cuislandora:72124.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Banasiak, Nancy. “Implementation of the Asthma Control Test in Primary Care to Improve Patient Outcomes.” 2018. Web. 18 Jan 2021.
Vancouver:
Banasiak N. Implementation of the Asthma Control Test in Primary Care to Improve Patient Outcomes. [Internet] [Thesis]. The Catholic University of America; 2018. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1961/cuislandora:72124.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Banasiak N. Implementation of the Asthma Control Test in Primary Care to Improve Patient Outcomes. [Thesis]. The Catholic University of America; 2018. Available from: http://hdl.handle.net/1961/cuislandora:72124
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California
7.
Carballo, Carlos Eliseo.
The association of asthma and asthma-related medications on
subclinical atherosclerosis: a cross-sectional analysis of four
randomized clinical trials.
Degree: MS, Biostatistics, 2012, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/97973/rec/6450
► Prior studies have evaluated the role of inflammation on atherosclerosis. The inflammatory process observed in asthmatics plays a central role in the cascade of events…
(more)
▼ Prior studies have evaluated the role of inflammation
on atherosclerosis. The inflammatory process observed in asthmatics
plays a central role in the cascade of events that may result in
cardiac events such as plaque erosion and plaque fissuring that can
trigger Cardiovascular Disease (CVD) complications such as
myocardial infarction and stroke. The current research evaluates
the association between carotid artery intima-media thickness
(CIMT), a measure of subclinical atherosclerosis, and
asthma. We
also evaluated the association between CIMT and use of
asthma
respiratory medications. ❧ Baseline data from 1248 subjects in four
randomized clinical trials were used to investigate the association
between CIMT and
asthma and respiratory medication (anti-
inflammatory non-steroidal, anti-inflammatory steroidal, bronchial
dilator and leukotriene receptor antagonist) use. The primary
outcome measure for all trials was CIMT. Asthmatics were identified
by self-report on a baseline health questionnaire. Respiratory
medication use was ascertained through collection of non-study
medication use (prescription and non-prescription) that used a
standard medication-coding scheme for all trials. Data were
analyzed using multiple linear regression, with CIMT as the
dependent variable and self-reported
asthma and use of respiratory
medications as the primary independent variables. Models were
adjusted for age, gender, trial, diabetes, race, weight, systolic
blood pressure, high-density lipoprotein (HDL) cholesterol, smoking
status, education and income when evaluating the association with
asthma. Models were adjusted for age, gender, trial, diabetes,
race, weight, systolic blood pressure, HDL cholesterol risk group,
smoking status and education when evaluating the association with
respiratory medication use. ❧ Mean CIMT did not differ between
asthmatics and non-asthmatics in unadjusted (p=0.95) and adjusted
(p=0.92) models. Exclusion of the subjects with pre-existing
coronary artery disease at baseline (n=226) did not alter these
results (p=0.81 for comparison of CIMT between asthmatics and
non-asthmatics). ❧ Similar non-significant results were observed
evaluating the association of respiratory medication use on CIMT
(p=0.66 in adjusted models in the total sample; p=0.87 in adjusted
models excluding subjects with coronary artery disease). ❧ These
data provide no evidence of an association between self-reported
asthma, use of respiratory medications, and CIMT measured
cross-sectionally. Future data analyses in these trials should
utilize the longitudinally-collected data to evaluate the
association of
asthma and respiratory medications with progression
of atherosclerosis.
Advisors/Committee Members: Mack, Wendy Jean (Committee Chair), Allayee, Hooman (Committee Member), Hodis, Howard N. (Committee Member).
Subjects/Keywords: asthma; atherosclerosis; asthma-related medications
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Manager
APA (6th Edition):
Carballo, C. E. (2012). The association of asthma and asthma-related medications on
subclinical atherosclerosis: a cross-sectional analysis of four
randomized clinical trials. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/97973/rec/6450
Chicago Manual of Style (16th Edition):
Carballo, Carlos Eliseo. “The association of asthma and asthma-related medications on
subclinical atherosclerosis: a cross-sectional analysis of four
randomized clinical trials.” 2012. Masters Thesis, University of Southern California. Accessed January 18, 2021.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/97973/rec/6450.
MLA Handbook (7th Edition):
Carballo, Carlos Eliseo. “The association of asthma and asthma-related medications on
subclinical atherosclerosis: a cross-sectional analysis of four
randomized clinical trials.” 2012. Web. 18 Jan 2021.
Vancouver:
Carballo CE. The association of asthma and asthma-related medications on
subclinical atherosclerosis: a cross-sectional analysis of four
randomized clinical trials. [Internet] [Masters thesis]. University of Southern California; 2012. [cited 2021 Jan 18].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/97973/rec/6450.
Council of Science Editors:
Carballo CE. The association of asthma and asthma-related medications on
subclinical atherosclerosis: a cross-sectional analysis of four
randomized clinical trials. [Masters Thesis]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/97973/rec/6450

University of Utah
8.
Teerlink, Craig C.
Analysis of Extended Pedigrees Ascertained for Asthma.
Degree: PhD, Biomedical Informatics;, 2010, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1632/rec/90
► This dissertation describes statistical analyses of an extended pedigree resource ascertained for asthma. The asthma pedigree resource contains 741 affected individuals in 81 pedigrees, with…
(more)
▼ This dissertation describes statistical analyses of an extended pedigree resource ascertained for asthma. The asthma pedigree resource contains 741 affected individuals in 81 pedigrees, with approximately 90 percent of the resource genotyped on 535 short tandem repeat markers dispersed throughout the genome. As a motivation for our analysis of the asthma pedigree resource, we first establish strong evidence for a heritable component to asthma using extensive population genealogical and phenotypic data from a combined resource of the Utah Population Database and the Utah death certificate registry. Subsequent analysis of the asthma pedigree resource itself consisted of various strategies designed to map the genomic locations of predisposition loci for asthma. First, we conducted a genomewide scan using a parametric linkage statistic and two general models. We interpreted the results of the scan using thresholds based on the asymptotic distribution of a related statistic and concluded that chromosomal region 5ql3 is linked to asthma under a recessive mode of inheritance. Second, recognizing that the selected thresholds used to interpret the outcomes of the first scan may be unreliable and that an empirical evaluation could be informative, we applied the latent p-value method for linkage to a genomewide scan of the resource. The latent p-value method offers fast empirical assessment, compared to conventional methods, and the flexibility to consider any linkage statistic without reference to any theoretical or asymptotic distribution. The latent p-value analysis confirmed the presence of linkage to chromosome 5ql3, albeit with a different linkage statistic than was used the in the original genomewide scan. Third, recognizing that consideration of only two general models may be insufficient to adequately model the true mode of inheritance at a linked locus, we conducted another genomewide scan using the modscore statistic, with the benefit of empirical assessment from the latent p-value method. The mod score analysis exhibited very low power to detect linkage and did not identify any new loci of interest. Taken together, our analyses indicate that there is linkage in this resource to chromosomal region 5ql3 and further expansion of this resource is warranted.
Subjects/Keywords: Asthma; Statistics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Teerlink, C. C. (2010). Analysis of Extended Pedigrees Ascertained for Asthma. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1632/rec/90
Chicago Manual of Style (16th Edition):
Teerlink, Craig C. “Analysis of Extended Pedigrees Ascertained for Asthma.” 2010. Doctoral Dissertation, University of Utah. Accessed January 18, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1632/rec/90.
MLA Handbook (7th Edition):
Teerlink, Craig C. “Analysis of Extended Pedigrees Ascertained for Asthma.” 2010. Web. 18 Jan 2021.
Vancouver:
Teerlink CC. Analysis of Extended Pedigrees Ascertained for Asthma. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Jan 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1632/rec/90.
Council of Science Editors:
Teerlink CC. Analysis of Extended Pedigrees Ascertained for Asthma. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1632/rec/90
9.
Tripathi, Prabhanshu.
Enzymes as allergen: molecular and immunological
studies.
Degree: 2009, University of Pune
URL: http://shodhganga.inflibnet.ac.in/handle/10603/2511
► The incidence of asthma and allergies has increased in many countries. As per estimates, 25% of the population worldwide suffers from allergic disorders including asthma…
(more)
▼ The incidence of asthma and allergies has increased
in many countries. As per estimates, 25% of the population
worldwide suffers from allergic disorders including asthma (Valenta
et al, 1999). Among the patients suffering with respiratory allergy
symptoms, 20-30% are sensitized to fungal spores (Gioulekas et al.,
2004). Allergic reactions progressively transform into regular
diseases defined as allergic rhinitis, asthma,
rhino-conjunctivitis, urticaria and eczema. The sensitization to
fungi has been reported in the range of 5-30% in India (Bisht et
al., 2003). Fungi such as Alternaria, Cladosporium, Aspergillus,
Penicillium, Curvularia, Epicoccum, Fusarium, Mucor and Rhizopus
have been recognized as important inhalant allergens at different
places in the world. Biologic function of certain allergens from
mites and fungi has been defined in previous studies (Bufe, 1998;
Pomes, 2008a). However, enzyme (protease) as allergen was first
reported in workers of detergent industry by Flindt (Flindt, 1969).
In the last decade, few other enzymes have been reported as
allergen and their mechanism of action was predicted (Pasquato et
al., 2006.). Enzyme allergens explored in most of the studies are
proteases, transferases, enolases, dehydrogenases and chitinases.
But, they are required to be developed in bulk amount using
recombinant DNA technology for in vitro and in vivo studies to
elucidate their mechanism of action in the target tissue especially
in airway disease. The enzyme like glutathione-S-transferase (GST)
has antioxidant property but the allergenic nature restricts its
use for therapeutic purpose. The variant of this enzyme may be of
therapeutic value in airway inflammatory disorders. newline
Oxidative stress is an important factor in the pathogenesis of
asthma. Furthermore, antioxidant like GST is reduced in asthma
patients. In the present study (Chapter 2), therapeutic effect of
exogenous GST and mGST was evaluated in allergen induced mice
model.
Abstract includes, References p.157-205, appendix
p.206-213
Advisors/Committee Members: Arora, Naveen.
Subjects/Keywords: Biotechnology; Asthma
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tripathi, P. (2009). Enzymes as allergen: molecular and immunological
studies. (Thesis). University of Pune. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/2511
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tripathi, Prabhanshu. “Enzymes as allergen: molecular and immunological
studies.” 2009. Thesis, University of Pune. Accessed January 18, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/2511.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tripathi, Prabhanshu. “Enzymes as allergen: molecular and immunological
studies.” 2009. Web. 18 Jan 2021.
Vancouver:
Tripathi P. Enzymes as allergen: molecular and immunological
studies. [Internet] [Thesis]. University of Pune; 2009. [cited 2021 Jan 18].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2511.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tripathi P. Enzymes as allergen: molecular and immunological
studies. [Thesis]. University of Pune; 2009. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2511
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
10.
Slager, Rebecca Elizabeth.
THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY.
Degree: 2010, Wake Forest University
URL: http://hdl.handle.net/10339/30390
► T helper 2 (Th2)-related interleukin 4/13 pathway genes have been associated with asthma susceptibility; however the role of these genes in asthma severity has not…
(more)
▼ T helper 2 (Th2)-related interleukin 4/13 pathway genes have been associated with asthma susceptibility; however the role of these genes in asthma severity has not been explored. We tested single nucleotide polymorphisms (SNPs) in the critical Th2 regulator GATA-binding protein 3 (GATA3) and other Th2 genes for association with baseline lung function, allergic symptoms, and health care utilization in non-Hispanic whites (n=437) and African-American (n=208) asthma patients in the Severe Asthma Research Program (SARP). Linear or ordinal regression models with an additive genetic term were developed to evaluate continuous or multi-level categorical variables. In SARP SNPs in GATA3 SNPs were associated with baseline lung function, including rs1244186, which was replicated in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. In SARP whites, GATA3 promoter polymorphisms, most notably rs1244181 [Odds Ratio (OR) 1.7, 95% Confidence Interval (CI) 1.23-2.36], were significantly associated with increasing use of inhaled and oral corticosteroids. GATA3 SNPs were also predictors of increased sinus infections, pollen allergy and SARP atopic asthma cluster phenotypes. This analysis provides evidence that GATA3 may contribute to modulation of baseline lung function, steroid use and atopy in severe asthma.
Subjects/Keywords: asthma
…Asthma
Degree of freedom
Emergency room
Forced Expiratory Volume in 1 second, percent of… …concentration of methacholine causing a 20% drop in
FEV1
Short-acting beta-agonist
Severe Asthma… …Natural History of Asthma: Outcomes and
Treatment Regimens
T helper 1
T helper 2
T helper 17
vi… …Rebecca E. Slager, Ph.D.
THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA
SEVERITY… …been
associated with asthma susceptibility; however the role of these genes in asthma…
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Slager, R. E. (2010). THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/30390
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Slager, Rebecca Elizabeth. “THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY.” 2010. Thesis, Wake Forest University. Accessed January 18, 2021.
http://hdl.handle.net/10339/30390.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Slager, Rebecca Elizabeth. “THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY.” 2010. Web. 18 Jan 2021.
Vancouver:
Slager RE. THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY. [Internet] [Thesis]. Wake Forest University; 2010. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10339/30390.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Slager RE. THE ROLE OF THE IL4/13 PATHWAY IN THE GENETICS OF ASTHMA SEVERITY. [Thesis]. Wake Forest University; 2010. Available from: http://hdl.handle.net/10339/30390
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town
11.
Van Niekerk, Christoffel Hendrik.
The prevalence of asthma in urban and rural Black children : an epidemiological survey.
Degree: Image, Paediatrics and Child Health, 1979, University of Cape Town
URL: http://hdl.handle.net/11427/26633
► This survey was undertaken: 1. to provide accurate information on the prevalence rates of asthma in Xhosa children living in an urban westernised community, Guguletu,…
(more)
▼ This survey was undertaken: 1. to provide accurate information on the prevalence rates of
asthma in Xhosa children living in an urban westernised community, Guguletu, Cape Town and in a rural traditional community, Tsolo District, Republic of Transkei; 2. to compare the findings of this survey with studies done elsewhere in the world on prevalence rates of
asthma among children; and 3. to evaluate and correlate factors that may influence these rates. To acquire the above, it was necessary 1. to obtain information on the characteristics and socio-economic status of the family of each child studied; 2. to obtain information on every child relating to exposure to allergens in his immediate home environment; 3. to obtain information on the dietary pattern of every child during infancy and currently; 4. to identify the asthmatic children by subjecting every child to an appropriate exercise stimulus for detection of exercise-induced
asthma judged by pulmonary function tests; 5. to conduct a clinical examination of the children. and skinfold thickness was also measured; Height, weight 6. to conduct prick skin testing to assess specific skin sensitivity to common allergens; 7. to conduct laboratory investigations relating to the allergic-immune status of the children; 8. arising out of these findings to relate the prevalence rates of
asthma in the 2 samples and to suggest factors influencing the rates.
Advisors/Committee Members: Heese, H de V (advisor).
Subjects/Keywords: Asthma
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Van Niekerk, C. H. (1979). The prevalence of asthma in urban and rural Black children : an epidemiological survey. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/26633
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Van Niekerk, Christoffel Hendrik. “The prevalence of asthma in urban and rural Black children : an epidemiological survey.” 1979. Thesis, University of Cape Town. Accessed January 18, 2021.
http://hdl.handle.net/11427/26633.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Van Niekerk, Christoffel Hendrik. “The prevalence of asthma in urban and rural Black children : an epidemiological survey.” 1979. Web. 18 Jan 2021.
Vancouver:
Van Niekerk CH. The prevalence of asthma in urban and rural Black children : an epidemiological survey. [Internet] [Thesis]. University of Cape Town; 1979. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/11427/26633.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Van Niekerk CH. The prevalence of asthma in urban and rural Black children : an epidemiological survey. [Thesis]. University of Cape Town; 1979. Available from: http://hdl.handle.net/11427/26633
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
12.
Sun, Ye.
Medication Adherence in Pediatric Asthma: A Preliminary Analysis of a Randomized Control Trial using Electronic Monitoring Devices.
Degree: MPH, Public Health, 2019, University of Connecticut
URL: https://opencommons.uconn.edu/gs_theses/1385
► Objective – Non-adherence to asthma medication is a common problem in patients with asthma, especially in children, leading to more frequent asthma exacerbations, ED…
(more)
▼ Objective – Non-adherence to
asthma medication is a common problem in patients with
asthma, especially in children, leading to more frequent
asthma exacerbations, ED visits and hospital admissions. Current methods of assessing adherence are unreliable. Electronic monitoring devices (EMDs) are more accurate means of assessing for adherence, but little is known about whether EMDs have a sustained effect on adherence in children. The objective of this study is to determine whether a mobile-based reminder system paired with EMD scan result in sustained improvement in adherence to
asthma therapy over six months.
Methods – Children (8-17 years) with physician-confirmed persistent
asthma, managed through the pulmonary division of Connecticut Children’s Medical Center, treated with a compatible daily inhaled corticosteroid, and with access to a smartphone were enrolled and randomized 2:1 to the intervention (EMD) or control (standard care) groups. Participants were followed at 3 and 6-months after enrollment. The intervention consists of the BreatheSmart
™ EMD (one for controller and one for rescue inhaler) synced with a mobile application that sends reminders and captures adherence data in real time. The primary outcome was adherence assessed as proportion of days covered (PDC) based on pharmacy refill among children in the intervention group compared to control after 6 months. Secondary outcome was adherence based on EMD data.
Results – 41 patients (29 in intervention, 12 in control) were enrolled. Adherence rates based on pharmacy refill at 6 months did not show any statistical significance between the intervention group compared to the control group (41% vs 31%, respectively;
p=0.21). Average adherence rate at 6 months based on EMDs for the intervention group (n=26) was 27.4%. While there was an initial high rate of adherence immediately after enrollment, adherence rates dropped significantly over the span of the 6 months.
Conclusion— Preliminary data suggest that adherence to controller therapy is no different among children utilizing an EMD with daily reminders when compared to a similar group of children receiving standard care. Despite an initial high rate of adherence with implementation of the intervention, such rates of adherence were not sustainable after 6 months.
Advisors/Committee Members: Dr. Jane Ungemack, Dr. Jessica Hollenbach, Dr. Chia-Ling Kuo, Dr. Jane Ungemack.
Subjects/Keywords: Asthma
…BACKGROUND Optimal asthma management is dependent on adequate control of asthma symptoms… …controlling asthma symptoms as well as in preventing
ED visits and hospitalizations (Barnes et… …for adequate asthma control (Lasmar et al, 2009; Williams et al,
2011). Yet… …to anti-inflammatory therapy in the form of ICS is associated with
significant asthma… …Non-adherence to asthma medication leads to overuse of reliever medication and more
frequent…
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sun, Y. (2019). Medication Adherence in Pediatric Asthma: A Preliminary Analysis of a Randomized Control Trial using Electronic Monitoring Devices. (Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/1385
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sun, Ye. “Medication Adherence in Pediatric Asthma: A Preliminary Analysis of a Randomized Control Trial using Electronic Monitoring Devices.” 2019. Thesis, University of Connecticut. Accessed January 18, 2021.
https://opencommons.uconn.edu/gs_theses/1385.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sun, Ye. “Medication Adherence in Pediatric Asthma: A Preliminary Analysis of a Randomized Control Trial using Electronic Monitoring Devices.” 2019. Web. 18 Jan 2021.
Vancouver:
Sun Y. Medication Adherence in Pediatric Asthma: A Preliminary Analysis of a Randomized Control Trial using Electronic Monitoring Devices. [Internet] [Thesis]. University of Connecticut; 2019. [cited 2021 Jan 18].
Available from: https://opencommons.uconn.edu/gs_theses/1385.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sun Y. Medication Adherence in Pediatric Asthma: A Preliminary Analysis of a Randomized Control Trial using Electronic Monitoring Devices. [Thesis]. University of Connecticut; 2019. Available from: https://opencommons.uconn.edu/gs_theses/1385
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba
13.
Balhara, Jyoti.
Role of PTX3 in allergic airway inflammation.
Degree: Immunology, 2013, University of Manitoba
URL: http://hdl.handle.net/1993/31935
► Thesis Abstract: Pentraxin 3 (PTX3) is a pattern recognition receptor that plays an important role in providing immunity against various pulmonary inflammatory conditions. Having known…
(more)
▼ Thesis Abstract:
Pentraxin 3 (PTX3) is a pattern recognition receptor that plays an important role in providing immunity against various pulmonary inflammatory conditions. Having known its role in fostering lung immunity, aim of my PhD thesis was to examine the role of PTX3 in
asthma. In my thesis, I showed an enhanced level of PTX3 in the airway fluid of severe asthmatics and also in the airway fluid and the lungs of allergen exposed mice. To further investigate the role of PTX3, I used a murine model of ovalbumin (OVA)-induced experimental
asthma and performed experiments on PTX3+/+ and PTX3-/- mice. I observed an enhanced airway inflammation and hyperactivity in OVA-exposed PTX3 Knockout (PTX3-/-) mice.
In PTX3-/- mice, there was an IL-17A dominant inflammation as compared to PTX3+/+ mice upon OVA challenge. This response was accompanied with increased CD4 T cell survival and reduced IL-2 production by these cells. As Th17 phenotype of CD4 T cells is shaped by IL-6 and IL-23 producing dendritic cells, we observed increased preponderance of such DCs in the lungs and the draining lymph nodes of PTX3-/- mice as compared to their PTX3+/+ counterparts, plausibly supporting Th17/ IL-17A dominant inflammation in the former.
Furthermore, there was increased infiltration of inflammatory DCs in the lungs in PTX3-/- mice upon OVA exposure. This observation was in line with increased generation of common myeloid progenitors in the bone marrow of these mice. PTX3-/- DCs showed reduced MHCII expression but increased surface expression of CD80 and CD86 along with increased ability of PTX3-/- DCs to uptake and process OVA. Since these DCs showed increase IL-6 and IL-23 production, co-culture of PTX3-/- DCs with OT II CD4 T cells resulted in greater IL-17A production as compared to those that were co-cultured with PTX3+/+ DCs.
Altogether, I have observed that deletion of PTX3 resulted in enhanced IL-17 immune response plausibly through increased IL-6 and IL-23 producing DCs in OVA-exposed mice. In summary, findings of my thesis provide insights of the novel regulatory role of PTX3 in allergic inflammation, primarily in context with CD4 T cell-DC axis.
Advisors/Committee Members: Soussi Gounni, Abdelilah (Immunology) (supervisor), Uzonna, Jude (Immunology) Mookherjee, Neeloffer (Immunology).
Subjects/Keywords: asthma; inflammation
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Balhara, J. (2013). Role of PTX3 in allergic airway inflammation. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31935
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Balhara, Jyoti. “Role of PTX3 in allergic airway inflammation.” 2013. Thesis, University of Manitoba. Accessed January 18, 2021.
http://hdl.handle.net/1993/31935.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Balhara, Jyoti. “Role of PTX3 in allergic airway inflammation.” 2013. Web. 18 Jan 2021.
Vancouver:
Balhara J. Role of PTX3 in allergic airway inflammation. [Internet] [Thesis]. University of Manitoba; 2013. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1993/31935.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Balhara J. Role of PTX3 in allergic airway inflammation. [Thesis]. University of Manitoba; 2013. Available from: http://hdl.handle.net/1993/31935
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen
14.
Hadebe, Sabelo Goodman.
The role of pathogen associated molecular patterns in the pathogenesis of asthma.
Degree: PhD, 2014, University of Aberdeen
URL: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153239240005941
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633282
► Asthma is a complex obstructive airway disease characterised by airway hyper-reactivity to innocuous allergens. It may be categorised as either classical eosinophilic, T helper 2…
(more)
▼ Asthma is a complex obstructive airway disease characterised by airway hyper-reactivity to innocuous allergens. It may be categorised as either classical eosinophilic, T helper 2 type of disease or as one driven by neutrophils that may be associated with T helper 17 cells and that is corticosteroid resistant. While the pathogenesis of the disease is not fully understood, there is increasing evidence for the role of environmentally-derived pathogen-associated molecular patterns (PAMPs) including fungal β-(1,3)-glucans and bacterial lipopolysaccharide (LPS) in inducing and exacerbating airway inflammation. We investigated the effects of these components, either alone or in combination, in several models of pulmonary inflammation and discovered that they modified airway responses in vivo. Notably, a combination of PAMPs drove a profound neutrophilia that was associated with synergistic CCL5 production. Moreover, in allergic models using house dust mite, sensitisation with these agonists resulted in corticosteroid resistant airway hyper-responsiveness. Interestingly, we found severe asthmatics with corticosteroid resistant neutrophilia to have upregulated CCL5 mRNA levels when compared to moderate asthmatics or controls. Interactions of environmental PAMPs from multiple sources could present a key determinant in the development and pathogenesis of corticosteroid resistant asthma.
Subjects/Keywords: 616.2; Asthma
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hadebe, S. G. (2014). The role of pathogen associated molecular patterns in the pathogenesis of asthma. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153239240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633282
Chicago Manual of Style (16th Edition):
Hadebe, Sabelo Goodman. “The role of pathogen associated molecular patterns in the pathogenesis of asthma.” 2014. Doctoral Dissertation, University of Aberdeen. Accessed January 18, 2021.
https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153239240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633282.
MLA Handbook (7th Edition):
Hadebe, Sabelo Goodman. “The role of pathogen associated molecular patterns in the pathogenesis of asthma.” 2014. Web. 18 Jan 2021.
Vancouver:
Hadebe SG. The role of pathogen associated molecular patterns in the pathogenesis of asthma. [Internet] [Doctoral dissertation]. University of Aberdeen; 2014. [cited 2021 Jan 18].
Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153239240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633282.
Council of Science Editors:
Hadebe SG. The role of pathogen associated molecular patterns in the pathogenesis of asthma. [Doctoral Dissertation]. University of Aberdeen; 2014. Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153239240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633282

University of Rochester
16.
Conn, Kelly M. (1972 - ).
The Relationship between parents' and children’s feelings
of helplessness and the child's asthma symptoms.
Degree: PhD, 2013, University of Rochester
URL: http://hdl.handle.net/1802/26615
► Managing chronic illnesses, such as asthma, includes implementing lifestyle and behavioral changes as well as coping strategies for emotional health. Research related to family functioning…
(more)
▼ Managing chronic illnesses, such as asthma,
includes implementing lifestyle and behavioral changes as well as
coping strategies for emotional health. Research related to family
functioning and its impact on asthma indicate that adverse family
functioning such as negative family climate, family routines, and
parent-child interactions may exacerbate children's asthma and are
related to increased morbidity. Feelings of helplessness
experienced within the family may further exacerbate symptoms.
Based on the theory of learned helplessness, individuals who feel
there is no connection between their behaviors and outcomes are
passive, anxious, depressed, and do not perform well. These
feelings have a powerful influence on behavior and emotion, thus,
likely impacting asthma morbidity. Only a few studies have assessed
feelings of helplessness among individuals with asthma, and no
studies have assessed these feelings in young children using
self-report. Additionally, little is known about the relationship
between feelings of helplessness and asthma morbidity among young
children. The objectives of this proposal were to: (1) survey
parents and children independently regarding their emotions and
feelings of helplessness specific to asthma and examine
associations between parent and child report, (2) examine the
relationship between parent's report of helplessness and the
child's asthma symptoms, and to also examine the relationship
between the child's report of helplessness and his/her asthma
symptoms, and (3) assess the relationship between the interaction
of parent and child helplessness and asthma symptoms using a model
that includes main effects and the constructed interaction term.
This study found a positive relationship between the child's
feelings of helplessness and symptom free days indicating less
feelings of helplessness as symptom free days increased. Parents'
feelings of helplessness were not related to the child's symptoms.
This relationship was true only among those families reporting
minimal social support and was not found among families with a lot
of support which may indicate a buffering effect of social support
among these families. Since stress and family environment has been
shown to impact asthma symptoms for some children, this buffering
effect of social support should be further explored among families
of children with asthma.
Subjects/Keywords: Asthma; Asthma symptoms; Children; Emotions; Helplessness; Parents
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Conn, K. M. (. -. ). (2013). The Relationship between parents' and children’s feelings
of helplessness and the child's asthma symptoms. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/26615
Chicago Manual of Style (16th Edition):
Conn, Kelly M (1972 - ). “The Relationship between parents' and children’s feelings
of helplessness and the child's asthma symptoms.” 2013. Doctoral Dissertation, University of Rochester. Accessed January 18, 2021.
http://hdl.handle.net/1802/26615.
MLA Handbook (7th Edition):
Conn, Kelly M (1972 - ). “The Relationship between parents' and children’s feelings
of helplessness and the child's asthma symptoms.” 2013. Web. 18 Jan 2021.
Vancouver:
Conn KM(-). The Relationship between parents' and children’s feelings
of helplessness and the child's asthma symptoms. [Internet] [Doctoral dissertation]. University of Rochester; 2013. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1802/26615.
Council of Science Editors:
Conn KM(-). The Relationship between parents' and children’s feelings
of helplessness and the child's asthma symptoms. [Doctoral Dissertation]. University of Rochester; 2013. Available from: http://hdl.handle.net/1802/26615

Durban University of Technology
17.
Rampersad, Shekaar Ramesh.
The short term relative effectiveness of two manual interventions in the management of chronic moderate asthma.
Degree: 2008, Durban University of Technology
URL: http://hdl.handle.net/10321/432
► Dissertation submitted in partial compliance with the requirements for the Masterà ¢ s Degree in Technology: Chiropractic, Durban University of Technology, 2008.
Objectives: To determine…
(more)
▼ Dissertation submitted in partial compliance with the requirements for the
Masterà ¢ s Degree in Technology: Chiropractic,
Durban University of Technology, 2008.
Objectives:
To determine the short-term effect of an inhaled, short-acting 2-agonist bronchodilator on chest wall expansion (cm) and lung function parameters (FEV1, FVC and FEV1/FVC%) in chronic moderate asthmatics.
To determine the short-term effect of spinal manipulation (SMT) and ribcage mobilisation on chest wall expansion (cm) and lung function parameters (FEV1, FVC and FEV1/FVC%) in chronic moderate asthmatics.
To determine the short-term effect of a combination of SMT, ribcage mobilisation and an inhaled, short-acting 2-agonist bronchodilator on chest wall expansion (cm) and lung function parameters (FEV1, FVC and FEV1/FVC%) in chronic moderate asthmatics.
Methods: Forty-five chronic moderate asthmatics who met all the inclusion criteria of the study were divided into three groups of fifteen each. Group A received a short-acting 2-agonist bronchodilator, Group B received SMT and ribcage mobilisation and Group C received a combination of SMT, ribcage mobilisation and a short-acting 2-agonist bronchodilator. Baseline measurements and testing included chest wall expansion and the lung function parameters FEV1, FVC and FEV1/FVC%. These measurements were repeated 15 minutes post-intervention. Data was analyzed using SPSS version 15.0. Results:
There were no statistically significant changes between pre- and post-intervention in the short-acting 2-agonist bronchodilator group with respect to any of the chest wall expansion measurements. There was a statisticallly significant increase in FEV1 between pre- and post-intervention in the short-acting 2-agonist bronchodilator group (p = 0.008). There was a statistically significant increase in the mean pre- and post-intervention axillary chest wall expansion (p = 0.014) as well as the mean of the half-way measurement (p = 0.014) and the overall mean chest wall expansion value (p = 0.001) following SMT and ribcage mobilisation. There were no statistically significant changes in any of the lung function parameter values following SMT and ribcage mobilisation. There was a significant increase for the half-way measurement in chest wall expansion (p = 0.018) in the combination of SMT, ribcage mobilisation and the inhaled, short-acting 2-agonist bronchodilator group. There were no statistically significant changes in any of the lung function parameter values in the combination of SMT, ribcage mobilisation and an inhaled, short-acting 2-agonist bronchodilator. For FEV1, the effect in the short-acting 2-agonist bronchodilator group vs. the SMT and ribcage mobilisation group was statistically significant (p = 0.018). There was no statistical difference in any of the chest wall expansion measurements and FVC and FEV1/FVC% parameters between all three groups. Conclusions The results did not point specifically to one intervention over another for all outcomes. SMT and rib mobilisation had no effect on the lung…
Advisors/Committee Members: Shaik, Junaid.
Subjects/Keywords: Spinal adjustment; Asthma – Treatment; Asthma – Chiropractic treatment
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rampersad, S. R. (2008). The short term relative effectiveness of two manual interventions in the management of chronic moderate asthma. (Thesis). Durban University of Technology. Retrieved from http://hdl.handle.net/10321/432
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rampersad, Shekaar Ramesh. “The short term relative effectiveness of two manual interventions in the management of chronic moderate asthma.” 2008. Thesis, Durban University of Technology. Accessed January 18, 2021.
http://hdl.handle.net/10321/432.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rampersad, Shekaar Ramesh. “The short term relative effectiveness of two manual interventions in the management of chronic moderate asthma.” 2008. Web. 18 Jan 2021.
Vancouver:
Rampersad SR. The short term relative effectiveness of two manual interventions in the management of chronic moderate asthma. [Internet] [Thesis]. Durban University of Technology; 2008. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10321/432.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rampersad SR. The short term relative effectiveness of two manual interventions in the management of chronic moderate asthma. [Thesis]. Durban University of Technology; 2008. Available from: http://hdl.handle.net/10321/432
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University
18.
Pang, Jinman.
Impact of Asthma Self-management Education On Childhood Asthma Outcomes.
Degree: 2015, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/24992
► Asthma is one of the most common respiratory disorders in children. Asthma self-management education programs aim to improve asthma treatment, management, and control in the…
(more)
▼ Asthma is one of the most common respiratory disorders in children.
Asthma self-management education programs aim to improve
asthma treatment, management, and control in the United States and help patients to develop the knowledge and skills about
asthma. Previous studies have shown that
asthma self-management education programs have improved quality of care for children and reduced medical care costs. However, most of these studies had small sample sizes or focused on children from one certain hospital or a selected region for analysis. To fill this gap, this study analyzes data from the 2006-2012 Behavioral Risk Factor Surveillance Survey (BRFSS)
Asthma Call-back Survey (ACBS). ACBS is a nationally representative survey of children with
asthma in the United States, which increases the generalizability of the findings.
Multinomial logistic regression models are used to analyze the association between participation in
asthma self-management education programs and health outcomes and healthcare utilization for children with
asthma. The results indicate that receiving more
asthma education is associated with fewer routine care visits, medical visits for
asthma episodes, hospitalizations, emergency department visits, and urgent care visits, and better control of
asthma symptoms. The benefits of
asthma education on hospitalizations and emergency department visits did not differ by financial hardship or race/ethnicity. This study provides evidence that
asthma self-management education improves health outcomes for children and reduces healthcare utilization.
Advisors/Committee Members: Marianne Messersmith Hillemeier, Thesis Advisor/Co-Advisor, Caprice A Knapp, Thesis Advisor/Co-Advisor, John Raymond Moran Jr., Thesis Advisor/Co-Advisor.
Subjects/Keywords: childhood asthma; asthma self-management education
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pang, J. (2015). Impact of Asthma Self-management Education On Childhood Asthma Outcomes. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/24992
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pang, Jinman. “Impact of Asthma Self-management Education On Childhood Asthma Outcomes.” 2015. Thesis, Penn State University. Accessed January 18, 2021.
https://submit-etda.libraries.psu.edu/catalog/24992.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pang, Jinman. “Impact of Asthma Self-management Education On Childhood Asthma Outcomes.” 2015. Web. 18 Jan 2021.
Vancouver:
Pang J. Impact of Asthma Self-management Education On Childhood Asthma Outcomes. [Internet] [Thesis]. Penn State University; 2015. [cited 2021 Jan 18].
Available from: https://submit-etda.libraries.psu.edu/catalog/24992.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pang J. Impact of Asthma Self-management Education On Childhood Asthma Outcomes. [Thesis]. Penn State University; 2015. Available from: https://submit-etda.libraries.psu.edu/catalog/24992
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg
19.
Shaw, Ina.
Development of a management model for the treatment of asthma.
Degree: 2010, University of Johannesburg
URL: http://hdl.handle.net/10210/3220
► D.Phil.
Asthma exemplifies a major medical concern and is a considerable cause of morbidity and mortality globally and in South Africa. Biokineticists have in the…
(more)
▼ D.Phil.
Asthma exemplifies a major medical concern and is a considerable cause of morbidity and mortality globally and in South Africa. Biokineticists have in the past primarily prescribed aerobic modes of exercise to asthmatics regardless of other modes of exercise that could be used in the management of asthma, each with their own unique benefits. The aim of this investigation was to develop a management model from a biokinetic perspective for the management of asthma in moderate, persistent asthmatics. The present study utilised a quantitative, comparative, research trial making use of a pre-test, eight-week intervention period and a post-test. Eighty-eight sedentary moderate, persistent asthmatics were matched by age and gender and randomly assigned to either a non-exercising control group (NE) (n = 22), an aerobic exercise group (AE) (n = 22), a diaphragmatic inspiratory resistive breathing group (DR) (n = 22) or an aerobic exercise combined with diaphragmatic resistive breathing group (CE) (n = 22). Dependent t-Tests and rank-ordered analyses revealed that five of the 13 pulmonary function parameters assessed were found to be significantly altered following the AE and CE training, with the CE training having a larger impact than AE training. The DR training resulted in improvements in four of the 13 pulmonary function parameters. The CE and AE training were also found to be equally effective at altering physical work capacity, while the DR training proved ineffective at altering physical work capacity. The CE training proved to be the most effective at improving the abdominal and chest wall excursion parameters. The DR training was found to be the least effective mode of exercise training to impact favourably on abdominal and chest wall excursion parameters. The DR and CE training had a similar significant and favourable change in respiratory muscle flexibility followed by the AE training only impacting on nine of the 11 respiratory muscle flexibility parameters. Regarding the respiratory muscle strength, despite AE and CE training altering 18 of the 20 parameters, CE training was found to be more effective. DR training only altered 16 of the 20 respiratory muscle strength parameters. The DR training was the only modality to alter a postural parameter, albeit unfavourably. Even though the DR and AE training significantly altered four of the six anthropometric parameters, the AE training proved to be superior, while CE training proved least effective as it altered v only three of the measured anthropometric parameters. The overall success of the CE training exemplified the fact that an optimal training regime for the management of asthma may require both an aerobic exercise and diaphragmatic inspiratory resistive breathing component. Exercise training, and specifically CE training is a cost-effective, home-based asthma management programme that may reduce the public health burden of this disease and provide the patient with alternative treatment options. CE training should form the cornerstone in the…
Subjects/Keywords: Asthma exercise therapy; Asthma treatment; Exercise therapy
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Shaw, I. (2010). Development of a management model for the treatment of asthma. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/3220
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Shaw, Ina. “Development of a management model for the treatment of asthma.” 2010. Thesis, University of Johannesburg. Accessed January 18, 2021.
http://hdl.handle.net/10210/3220.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Shaw, Ina. “Development of a management model for the treatment of asthma.” 2010. Web. 18 Jan 2021.
Vancouver:
Shaw I. Development of a management model for the treatment of asthma. [Internet] [Thesis]. University of Johannesburg; 2010. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10210/3220.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Shaw I. Development of a management model for the treatment of asthma. [Thesis]. University of Johannesburg; 2010. Available from: http://hdl.handle.net/10210/3220
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
Suzuki, Kazuo.
Analysis of perimenstrual asthma based on questionnaire surveys in Japan. : 質問票を用いた日本での月経喘息の検討.
Degree: 博士(医学), 2017, Niigata University / 新潟大学
URL: http://hdl.handle.net/10191/47633
► 学位の種類: 博士(医学). 報告番号: 乙第2206号. 学位記番号: 新大院博(医)乙第1785号. 学位授与年月日: 平成29年3月23日
Allergology International 2007, 56; 249-255
Background: Perimenstrual asthma (PMA) has been documented in 30% to 40% of…
(more)
▼ 学位の種類: 博士(医学). 報告番号: 乙第2206号. 学位記番号: 新大院博(医)乙第1785号. 学位授与年月日: 平成29年3月23日
Allergology International 2007, 56; 249-255
Background: Perimenstrual asthma (PMA) has been documented in 30% to 40% of asthmatic women; the characteristics of PMA have also been well described. However, there have been few epidemiological investigations of PMA in practice. In this study, we analyzed PMA based on a questionnaire survey carried out in Japan and compared the results with those of studies reported previously. Methods: For 8 weeks from September through October 2004, a uestionnaire survey was administered to patients with bronchial asthma and their attending physicians. The questionnaire surveyed asthma control,asthma-related emergencies and satisfaction in daily life. The attending physicians were questioned about patient profiles and medications. All female patients who were menstruating during the survey period and who were known to have asthma exacerbation related to menstruation were allocated to the PMA group; those who were not were allocated to the non-PMA group. Results: The rate of PMA in female patients who were menstruating during the survey period was 11.3% in this study. Characteristic features of the PMA group (n = 54) included more severe disease, worsened disease control and more aggressive patient management, including increased oral corticosteroid use compared with the non-PMA group. The rates of emergency episodes in the PMA group were higher than in the non-PMA group. There was a significant increase in aspirin intolerant asthma (AIA, 25.5%) in the PMA group compared with the non-PMA group (8.4%). Conclusions: Attention should be paid to the lack of knowledge regarding PMA in patients with asthma in actual clinical settings. The low rate of PMA reported in this study may be due to the study method using selfreports of PMA by patients without sufficient knowledge, and may not be an accurate representation of the actual incidence of the disease. The clinical similarity of PMA to AIA in this study may also provide a new insight into the mechanism of PMA.
Subjects/Keywords: aspirin intolerant asthma; perimenstrual asthma; questionnaire survey
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Suzuki, K. (2017). Analysis of perimenstrual asthma based on questionnaire surveys in Japan. : 質問票を用いた日本での月経喘息の検討. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/47633
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Suzuki, Kazuo. “Analysis of perimenstrual asthma based on questionnaire surveys in Japan. : 質問票を用いた日本での月経喘息の検討.” 2017. Thesis, Niigata University / 新潟大学. Accessed January 18, 2021.
http://hdl.handle.net/10191/47633.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Suzuki, Kazuo. “Analysis of perimenstrual asthma based on questionnaire surveys in Japan. : 質問票を用いた日本での月経喘息の検討.” 2017. Web. 18 Jan 2021.
Vancouver:
Suzuki K. Analysis of perimenstrual asthma based on questionnaire surveys in Japan. : 質問票を用いた日本での月経喘息の検討. [Internet] [Thesis]. Niigata University / 新潟大学; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10191/47633.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Suzuki K. Analysis of perimenstrual asthma based on questionnaire surveys in Japan. : 質問票を用いた日本での月経喘息の検討. [Thesis]. Niigata University / 新潟大学; 2017. Available from: http://hdl.handle.net/10191/47633
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle
21.
Pinkerton , James.
Elucidating the mechanisms of steroid-resistant asthma.
Degree: PhD, 2018, University of Newcastle
URL: http://hdl.handle.net/1959.13/1383707
► Research Doctorate - Doctor of Philosophy (PhD)
Severe, steroid-resistant (SSR) asthma is of considerable clinical and economic significance as affected individuals do not respond to…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Severe, steroid-resistant (SSR) asthma is of considerable clinical and economic significance as affected individuals do not respond to mainstay corticosteroid therapies. Patients with SSR asthma experience more frequent exacerbations of disease, are more likely to require hospitalisation and have a poor quality of life. Improved therapies are urgently required for SSR asthma, however, progress in this area has been hampered by a lack of understanding of the pathological processes that underpin disease. The major obstacle to understanding the processes that drive SSR asthma is that there are several subsets of the disease characterised by different inflammatory and immunological phenotypes. This heterogeneity disease makes pinpointing the key processes that underpin disease extremely difficult in humans. To help understand the mechanisms that underpin SSR asthma, we have developed three unique infection-induced models of SSR asthma. As part of my thesis, I have also developed a high fat diet-induced, obesity-associated SSR asthma. Together, all four models recapitulate the key features of a number of different subsets/clusters of SSR asthma in the clinic and represent useful tools to understand subset-specific and universal factors/processes that underpin of disease and test novel therapies that target the factors/processes identified. The overarching aim of my PhD is to utilise these models to elucidate novel mechanisms that may underpin SSR asthma and to determine whether targeting these mechanisms with therapeutic interventions can suppress disease, where steroids are not effective. My PhD was divided into three major aims that have focused on discovering novel factors associated with disease and assessing the roles played by known associative factors potentially drive steroid resistance. Firstly, I conducted array analyses on whole lung tissue from our three models of infection-induced SSR asthma, that represent different inflammatory and immune subsets observed in the clinic, to identify factors that are universally dysregulated in disease. I identified 11 universally dysregulated genes, most of which have not been previously recognised in SSR asthma (chapter 2). I then showed the functional role that one of these factors may being playing in driving SSR asthma (chapter 2). Secondly, I have identified dysregulated antioxidant responses as playing a critical role in our Chlamydia-induced model of SSR asthma and show that restoration of antioxidant responses may be a beneficial adjunct therapy for steroid-resistant disease (chapter 3). Lastly, I have developed a new murine model of high fat diet (HFD)-induced obesity that induces SSR allergic airways disease (AAD) (chapter 4). I used this model to identify a previously unrecognised role for HFD/obesity-induced, NLRP3 inflammasome-mediated responses in the lung the development of steroid-resistant airways hyper-responsiveness (AHR). I also show that HFD/obesity induced NLRP3 inflammasome responses in the lung may be…
Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Biomedical Sciences & Pharmacy.
Subjects/Keywords: asthma; severe asthma; steroid resistance; infection; obesity
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pinkerton , J. (2018). Elucidating the mechanisms of steroid-resistant asthma. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1383707
Chicago Manual of Style (16th Edition):
Pinkerton , James. “Elucidating the mechanisms of steroid-resistant asthma.” 2018. Doctoral Dissertation, University of Newcastle. Accessed January 18, 2021.
http://hdl.handle.net/1959.13/1383707.
MLA Handbook (7th Edition):
Pinkerton , James. “Elucidating the mechanisms of steroid-resistant asthma.” 2018. Web. 18 Jan 2021.
Vancouver:
Pinkerton J. Elucidating the mechanisms of steroid-resistant asthma. [Internet] [Doctoral dissertation]. University of Newcastle; 2018. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1959.13/1383707.
Council of Science Editors:
Pinkerton J. Elucidating the mechanisms of steroid-resistant asthma. [Doctoral Dissertation]. University of Newcastle; 2018. Available from: http://hdl.handle.net/1959.13/1383707
22.
Siti Rahmalia Hairani Damanik.
The Effect of asthma educational program on self-efficacy in Skill management of Asthma in Pekanbaru, Indonesia
.
Degree: คณะพยาบาลศาสตร์, 2009, Prince of Songkla University
URL: http://kb.psu.ac.th/psukb/handle/2016/12904
Subjects/Keywords: Asthma;
Asthma Treatment
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Damanik, S. R. H. (2009). The Effect of asthma educational program on self-efficacy in Skill management of Asthma in Pekanbaru, Indonesia
. (Thesis). Prince of Songkla University. Retrieved from http://kb.psu.ac.th/psukb/handle/2016/12904
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Damanik, Siti Rahmalia Hairani. “The Effect of asthma educational program on self-efficacy in Skill management of Asthma in Pekanbaru, Indonesia
.” 2009. Thesis, Prince of Songkla University. Accessed January 18, 2021.
http://kb.psu.ac.th/psukb/handle/2016/12904.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Damanik, Siti Rahmalia Hairani. “The Effect of asthma educational program on self-efficacy in Skill management of Asthma in Pekanbaru, Indonesia
.” 2009. Web. 18 Jan 2021.
Vancouver:
Damanik SRH. The Effect of asthma educational program on self-efficacy in Skill management of Asthma in Pekanbaru, Indonesia
. [Internet] [Thesis]. Prince of Songkla University; 2009. [cited 2021 Jan 18].
Available from: http://kb.psu.ac.th/psukb/handle/2016/12904.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Damanik SRH. The Effect of asthma educational program on self-efficacy in Skill management of Asthma in Pekanbaru, Indonesia
. [Thesis]. Prince of Songkla University; 2009. Available from: http://kb.psu.ac.th/psukb/handle/2016/12904
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen
23.
Al-Makoshi, Amel Abdullah.
Study of asthma to investigate in utero effects of diet (Saudi).
Degree: PhD, 2014, University of Aberdeen
URL: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152533700005941
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606485
► Objective: Reduced maternal levels of vitamin D, E and zinc during pregnancy has been linked to the development of asthma and allergic disease in children.…
(more)
▼ Objective: Reduced maternal levels of vitamin D, E and zinc during pregnancy has been linked to the development of asthma and allergic disease in children. The birth cohort investigated if maternal dietary intake in pregnant Saudi women was associated with childhood asthma and allergic disease up to 24 months of age. Methods: One thousand six hundred and twenty four women were recruited to a prospective birth cohort from an antenatal clinic in Riyadh, Saudi Arabia. A food frequency questionnaire was used to characterize diet during pregnancy and serum micronutrient levels were measured. 1436 singleton children were followed up at 6, 12 and 24 months of age by interview administrated telephone calls. Results: Multivariate analyses revealed no associations between the primary maternal dietary nutrient intakes of vitamin E and zinc and the respiratory outcomes in the cohort children at 24 months of age. There was a borderline significant association between increasing maternal zinc intake and maternal reports of food allergy in the cohort children at 24 months. Positive associations with maternal dietary folate intake with maternally reported ‘itchy rash for at least 6 consecutive months' (OR= 2.36 p-=0.020) and any food allergies (OR= 2.18 p= 0.025). Conclusion: This study suggests no conclusive evidence that maternal intake of vitamin D, E and zinc of Saudi women may lower the risks of developing asthma and allergic disease in early childhood. However, a higher dietary intake of folate during pregnancy increased the risk of reported itchy rash, eczema and food allergy in the cohort children up to 24 months. Further follow up of the cohort will provided evidence that will support or refute whether maternal diet during pregnancy is associated with asthma and allergic disease in childhood.
Subjects/Keywords: 614; Pregnancy; Asthma; Asthma in children
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APA ·
Chicago ·
MLA ·
Vancouver ·
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APA (6th Edition):
Al-Makoshi, A. A. (2014). Study of asthma to investigate in utero effects of diet (Saudi). (Doctoral Dissertation). University of Aberdeen. Retrieved from https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152533700005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606485
Chicago Manual of Style (16th Edition):
Al-Makoshi, Amel Abdullah. “Study of asthma to investigate in utero effects of diet (Saudi).” 2014. Doctoral Dissertation, University of Aberdeen. Accessed January 18, 2021.
https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152533700005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606485.
MLA Handbook (7th Edition):
Al-Makoshi, Amel Abdullah. “Study of asthma to investigate in utero effects of diet (Saudi).” 2014. Web. 18 Jan 2021.
Vancouver:
Al-Makoshi AA. Study of asthma to investigate in utero effects of diet (Saudi). [Internet] [Doctoral dissertation]. University of Aberdeen; 2014. [cited 2021 Jan 18].
Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152533700005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606485.
Council of Science Editors:
Al-Makoshi AA. Study of asthma to investigate in utero effects of diet (Saudi). [Doctoral Dissertation]. University of Aberdeen; 2014. Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152533700005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606485

University of Aberdeen
24.
Allan, Keith M.
Maternal diet during pregnancy and childhood asthma : a prospective study.
Degree: PhD, 2011, University of Aberdeen
URL: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153029180005941
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553745
► The SEATON cohort comprising 2000 pregnant women recruited 1997-99 was established to test if maternal nutrition during pregnancy affects the likelihood of children developing asthma.…
(more)
▼ The SEATON cohort comprising 2000 pregnant women recruited 1997-99 was established to test if maternal nutrition during pregnancy affects the likelihood of children developing asthma. At 32 weeks gestation mothers’ diets were assessed by food frequency questionnaire. 1,924 live singleton births comprised the birth cohort with follow-up at 6 months, 1, 2, 5 and 10 years (the latter the focus of this thesis). Children’s diets were assessed at 5 and 10 years. Their asthmatic status was assessed by International Study of Asthma and Allergies in Childhood questionnaire. Children participating at 5 or 10 years were also invited for measurement of spirometry and allergy. Cross-sectionally at 10 years 934 children (48% boys) participated by return of questionnaire, 449 also took part in the in-depth assessment. Higher maternal vitamin D intakes were associated with decreased odds of ‘doctor diagnosed asthma’, ‘wheeze ever’ and ‘wheeze in the last year’ in the children. Contrary to findings at 5 years no association between maternal vitamin E intake and asthma outcomes was seen. Longitudinally over the 10 years of the study, higher maternal vitamin D and E intakes during pregnancy were both associated with a decreased likelihood of ‘doctor diagnosed asthma’, ‘active asthma’ and ‘wheeze in the last year’ in the children. In conclusion, reduced maternal vitamin D and E intakes during pregnancy are associated with an increased likelihood of childhood asthma during the first ten years of life. Vitamin E appears to be associated with early asthma and wheeze possibly reflecting a role in affecting early airway remodelling processes. Associations with vitamin D were seen consistently over different time-points, possibly having its effect in an immunomodulatory fashion. Intervention trials are required to ascertain if intervention during pregnancy actually reduces childhood asthma rates.
Subjects/Keywords: 618.92238; Pregnancy; Asthma; Asthma in children
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Allan, K. M. (2011). Maternal diet during pregnancy and childhood asthma : a prospective study. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153029180005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553745
Chicago Manual of Style (16th Edition):
Allan, Keith M. “Maternal diet during pregnancy and childhood asthma : a prospective study.” 2011. Doctoral Dissertation, University of Aberdeen. Accessed January 18, 2021.
https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153029180005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553745.
MLA Handbook (7th Edition):
Allan, Keith M. “Maternal diet during pregnancy and childhood asthma : a prospective study.” 2011. Web. 18 Jan 2021.
Vancouver:
Allan KM. Maternal diet during pregnancy and childhood asthma : a prospective study. [Internet] [Doctoral dissertation]. University of Aberdeen; 2011. [cited 2021 Jan 18].
Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153029180005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553745.
Council of Science Editors:
Allan KM. Maternal diet during pregnancy and childhood asthma : a prospective study. [Doctoral Dissertation]. University of Aberdeen; 2011. Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153029180005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553745

NSYSU
25.
Tai, Chih-Chiang.
Pediatric asthma and medical resources utilization.
Degree: Master, Institute of Health Care Management, 2008, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829108-114112
► Background Children with asthma usually use more medical resources than those without asthma. However, studies on the relationship between ratios of asthma-related complications and consumption…
(more)
▼ Background
Children with
asthma usually use more medical resources than those without
asthma. However, studies on the relationship between ratios of
asthma-related complications and consumption of medical resources are rare.
Methods
We sampled data from âRegistry for beneficiariesâ of âNational Health Insurance Research Databaseâ, National Health Insurance Institute, 2004. The target group was patients, aged between 1 and 18 years old, whose main diagnosis number from outpatient department (ICD-9-CM) is 493. Ratios of
asthma-related complications and consumption of medical costs and resources were submitted to statistical analysis.
Results
Data of 394197 outpatients, of whom 62.5% are males, were included. Among the entire sample, 7627 children have
asthma. Children with
asthma are 8.2 times likely to get allergic rhinitis than those without
asthma. Children with
asthma are 2.1 times likely to get atopic dermatitis, 1.3 times likely to get otitis media, 1.5 times likely to get sinusitis than those without
asthma. With regard to average expenditure on medical treatment, that of children with
asthma is higher than that of children without
asthma. Expenditures on medical treatment are compared among four divided groups. Children without
asthma or complications ( NT 3714 ± 24538 ) , Children without
asthma having complications ( NT 6448 ± 8880 ) , children with
asthma not having complications ( NT 7396 ± 6434 ) , children with
asthma having complications ( NT 12708 ± 10585 ) . Results of expenditures on medical treatment among these four divided groups show statistically significant. Seventy % of medical resources utilized are pediatrics, 40% are clinics, 50% are in the northern area.
Conclusion
Ratio of comorbidities of children with
asthma is obviously higher than that of children without
asthma. With regard to medical costs, that of children with
asthma having comorbidities is higher than that of children with
asthma not having comorbidities. Therefore, local pediatricians have an important role in the care of children with
asthma.
Advisors/Committee Members: Jen-Her Wu (chair), Ying-Chun Li (committee member), Lawrence Sun (chair).
Subjects/Keywords: asthma; medical resources
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tai, C. (2008). Pediatric asthma and medical resources utilization. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829108-114112
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tai, Chih-Chiang. “Pediatric asthma and medical resources utilization.” 2008. Thesis, NSYSU. Accessed January 18, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829108-114112.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tai, Chih-Chiang. “Pediatric asthma and medical resources utilization.” 2008. Web. 18 Jan 2021.
Vancouver:
Tai C. Pediatric asthma and medical resources utilization. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Jan 18].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829108-114112.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tai C. Pediatric asthma and medical resources utilization. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0829108-114112
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta
26.
Skappak, Christopher Dustin.
Virus Induced Asthma Exacerbations: Immunologic Mechanisms
and Metabolomic Biomarkers.
Degree: PhD, Medical Sciences-Paediatrics, 2014, University of Alberta
URL: https://era.library.ualberta.ca/files/tq57nr07h
This thesis examines the pathophysiology of asthma,
attempts to determine the cellular mechanisms behind viral-induced
immune memory mediated asthma exacerbations, and investigates
urinary metabolomic biomarkers of asthma and neonatal
hypoxia.
Subjects/Keywords: Virus; Asthma; Metabolomics
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Skappak, C. D. (2014). Virus Induced Asthma Exacerbations: Immunologic Mechanisms
and Metabolomic Biomarkers. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/tq57nr07h
Chicago Manual of Style (16th Edition):
Skappak, Christopher Dustin. “Virus Induced Asthma Exacerbations: Immunologic Mechanisms
and Metabolomic Biomarkers.” 2014. Doctoral Dissertation, University of Alberta. Accessed January 18, 2021.
https://era.library.ualberta.ca/files/tq57nr07h.
MLA Handbook (7th Edition):
Skappak, Christopher Dustin. “Virus Induced Asthma Exacerbations: Immunologic Mechanisms
and Metabolomic Biomarkers.” 2014. Web. 18 Jan 2021.
Vancouver:
Skappak CD. Virus Induced Asthma Exacerbations: Immunologic Mechanisms
and Metabolomic Biomarkers. [Internet] [Doctoral dissertation]. University of Alberta; 2014. [cited 2021 Jan 18].
Available from: https://era.library.ualberta.ca/files/tq57nr07h.
Council of Science Editors:
Skappak CD. Virus Induced Asthma Exacerbations: Immunologic Mechanisms
and Metabolomic Biomarkers. [Doctoral Dissertation]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/tq57nr07h

University of Newcastle
27.
Warsanah, Irwan Hanish bin.
Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases.
Degree: PhD, 2015, University of Newcastle
URL: http://hdl.handle.net/1959.13/1305657
► Research Doctorate - Doctor of Philosophy (PhD)
Influenza infections are of major importance as they have a significant impact on the health of individuals and…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Influenza infections are of major importance as they have a significant impact on the health of individuals and impart substantial socio-economic ramifications on society. Prevention and treatment of influenza infections are complicated by frequent genetic mutations of the influenza virus. Patients with underlying chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and asthma are more susceptible to influenza infection, and infection with influenza exacerbates these diseases. Therefore, elucidation of the mechanisms underpinning increased susceptibility to influenza in these patients is vital. Here, we established an experimental mouse model of COPD and utilised an existing ovalbumin-induced allergic airways disease (AAD) model to investigate the effects of influenza infection in COPD and asthma, respectively. Influenza infection in experimental COPD resulted in increased viral titre, exaggerated airway inflammation and further impaired lung function. These effects were accompanied by decreased neutrophil influx into the airways, reduced antiviral interferon responses, and the suppression of a range of cytokines and chemokines, including interferon (IFN)-γ, tumour necrosis factor (TNF)-α, IFN-γ-induced protein (IP)-10, macrophage inflammatory protein (MIP)-1α, keratinocyte-derived chemokine (KC, or IL-8 in humans) and interleukin (IL)-10, as well as increased IL-6. This increased susceptibility was mediated by an increase in phosphoinositide 3-kinase (PI3K) protein expression. The inhibition of PI3K effectively reduced viral titre, enhanced antiviral IFNs and improved lung function. Influenza infection in recombinant IL-13-treated or ovalbumin (Ova)-induced AAD models led to increased viral titre, impaired antiviral responses and increased airway hyper-responsiveness (AHR). It also resulted in exaggerated airway inflammation, more severe histopathology, increased mucus secreting cell numbers and increased IL-13. Importantly, we also showed that inhibition of IL-13 by administration of anti-IL-13 (αIL-13) monoclonal antibody during influenza infection reduced viral titre, AHR, eosinophil infiltration and MSCs, which were associated with improved antiviral IFN responses. In summary, these data highlight the important roles of PI3K and IL-13 in the increased susceptibility to influenza infection in experimental models of COPD and asthma, respectively. Such findings offer evidence for new and promising avenues for influenza disease management in these chronic lung diseases. In fact, both PI3K inhibitors and anti-IL-13 antibodies have already entered clinical trials and may be utilised as novel therapeutic approaches for influenza infections in the future.
Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Biomedical Sciences and Pharmacy.
Subjects/Keywords: influenza; asthma; COPD
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Warsanah, I. H. b. (2015). Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1305657
Chicago Manual of Style (16th Edition):
Warsanah, Irwan Hanish bin. “Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases.” 2015. Doctoral Dissertation, University of Newcastle. Accessed January 18, 2021.
http://hdl.handle.net/1959.13/1305657.
MLA Handbook (7th Edition):
Warsanah, Irwan Hanish bin. “Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases.” 2015. Web. 18 Jan 2021.
Vancouver:
Warsanah IHb. Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1959.13/1305657.
Council of Science Editors:
Warsanah IHb. Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1305657

University of Newcastle
28.
Berthon, Bronwyn.
Investigating the link between corticosteroids and diet in adults with asthma.
Degree: PhD, 2014, University of Newcastle
URL: http://hdl.handle.net/1959.13/1051152
► Research Doctorate - Doctor of Philosophy (PhD)
Asthma is public health problem, affecting adults and children of all ages globally. As there is no cure…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Asthma is public health problem, affecting adults and children of all ages globally. As there is no cure for asthma, optimum management of the condition is essential through appropriate pharmacotherapy and modification of environmental and lifestyle risk factors. Dietary intake and weight gain are important environmental exposures that may contribute to pathogenesis and progression of asthma, given the proposed association of asthma and obesity and evidence that some dietary nutrients affect asthma outcomes beneficially or adversely. Furthermore it is unknown whether asthma treatment medication, such as oral or inhaled corticosteroids impact upon dietary intake or cause weight gain and whether biological markers such as leptin are important in this association. Further investigation into these risk factors is required to improve asthma management. The current thesis aims to describe the dietary intake of adults with asthma; to investigate the association of dietary nutrient intake with corticosteroids and asthma outcomes; and to examine whether oral corticosteroids affect appetite, dietary intake, body weight and body composition in adults with asthma. Chapter 2 presents the current evidence for the effect of oral corticosteroids on appetite, dietary intake, body weight and body composition. In this systematic literature review we found it was unlikely that oral corticosteroids have a significant effect on dietary intake, appetite or body weight and composition when used to treat inflammatory conditions or in healthy subjects. There is limited objective evidence for the association of oral corticosteroids and these adverse effects, particularly with respect to short term oral corticosteroid therapy in inflammatory conditions, including asthma. In Chapter 3 the dietary intake of adults with asthma was examined; compared to healthy subjects; and evaluated for associations with biological markers and asthma outcomes. Subjects with severe asthma were found to have a different dietary intake to healthy subjects, with an increased intake of fat and sodium and decreased intake of fibre and potassium. In all subjects with asthma increased fat and decreased fibre intake were associated with greater airway inflammation and poorer lung function. This finding suggests that these nutrients may be important to address in nutritional counselling of adults with asthma. There was no relationship between dietary intake and inhaled or oral corticosteroids. Serum leptin was increased in subjects with asthma compared to healthy controls, and while it was not directly related to dietary intake, it was associated with inhaled corticosteroid use in males. This finding is an indication that leptin may be important to investigate further in the relationship between appetite and corticosteroid use in asthma. Chapter 4 explored the effects of a short term oral corticosteroid intervention on appetite, dietary intake, leptin, body weight and body composition in adults with asthma. This 10 day,…
Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Biomedical Sciences and Pharmacy.
Subjects/Keywords: asthma; diet; inflammation
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Berthon, B. (2014). Investigating the link between corticosteroids and diet in adults with asthma. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1051152
Chicago Manual of Style (16th Edition):
Berthon, Bronwyn. “Investigating the link between corticosteroids and diet in adults with asthma.” 2014. Doctoral Dissertation, University of Newcastle. Accessed January 18, 2021.
http://hdl.handle.net/1959.13/1051152.
MLA Handbook (7th Edition):
Berthon, Bronwyn. “Investigating the link between corticosteroids and diet in adults with asthma.” 2014. Web. 18 Jan 2021.
Vancouver:
Berthon B. Investigating the link between corticosteroids and diet in adults with asthma. [Internet] [Doctoral dissertation]. University of Newcastle; 2014. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1959.13/1051152.
Council of Science Editors:
Berthon B. Investigating the link between corticosteroids and diet in adults with asthma. [Doctoral Dissertation]. University of Newcastle; 2014. Available from: http://hdl.handle.net/1959.13/1051152

Victoria University of Wellington
29.
Fingleton, James.
Phenotyping of obstructive airways disease.
Degree: 2013, Victoria University of Wellington
URL: http://hdl.handle.net/10063/3127
► Background Asthma and Chronic Obstructive Pulmonary Disease (COPD) are heterogeneous disorders which may be made up of different sub-types, or phenotypes, of airflow obstruction with…
(more)
▼ Background
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are heterogeneous disorders which may be made up of different sub-types, or phenotypes, of airflow obstruction with distinct clinical characteristics. To facilitate personalised treatment the different phenotypes and their response to treatment must be clearly defined and sound diagnostic rules developed.
In this thesis I explore the evidence supporting candidate phenotypes and report the results of my research, known as the New Zealand Respiratory Health Survey (NZRHS). The NZRHS was designed to determine candidate phenotypes, compare these phenotypes to those previously described, characterize their response to inhaled medication, and develop a method for allocating patients to the most appropriate phenotype.
Research Aims
-To explore clinical phenotypes of chronic airways disease by cluster analysis.
-To examine if phenotypes identified by a previous cluster analysis exist in the independent NZRHS sample.
-To compare the response to a short-acting beta-agonist inhaler between phenotype groups.
-To compare the response to a short-acting muscarinic antagonist inhaler between phenotype groups.
-To compare the response to an inhaled corticosteroid between phenotype groups.
-To generate allocation rules and determine their predictive value for the different disorders of airways disease.
Conclusions
This research has identified phenotypes of airways disease that differ significantly in their clinical and pathophysiological characteristics. Evidence is presented to support the existence of the
asthma/COPD overlap and obesity/co-morbid phenotypes and provide data of their responsiveness to inhaled corticosteroid, beta agonist and anti-muscarinic treatments, which may guide future management of patients with these phenotypes of obstructive airways disease.
Advisors/Committee Members: Beasley, Richard, Miller, John.
Subjects/Keywords: Asthma; COPD; Phenotype
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fingleton, J. (2013). Phenotyping of obstructive airways disease. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/3127
Chicago Manual of Style (16th Edition):
Fingleton, James. “Phenotyping of obstructive airways disease.” 2013. Doctoral Dissertation, Victoria University of Wellington. Accessed January 18, 2021.
http://hdl.handle.net/10063/3127.
MLA Handbook (7th Edition):
Fingleton, James. “Phenotyping of obstructive airways disease.” 2013. Web. 18 Jan 2021.
Vancouver:
Fingleton J. Phenotyping of obstructive airways disease. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2013. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10063/3127.
Council of Science Editors:
Fingleton J. Phenotyping of obstructive airways disease. [Doctoral Dissertation]. Victoria University of Wellington; 2013. Available from: http://hdl.handle.net/10063/3127
30.
Denford, Sarah.
An analysis of the application of the MESH intervention in asthma.
Degree: Thesis (D.Health Psy.), 2014, University of the West of England, Bristol
URL: https://uwe-repository.worktribe.com/output/812650
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619063
► Background: Asthma control is currently suboptimal for many individuals with asthma. A number of systematic reviews show that interventions are effective for improving asthma self-care…
(more)
▼ Background: Asthma control is currently suboptimal for many individuals with asthma. A number of systematic reviews show that interventions are effective for improving asthma self-care in adults. However, the processes underpinning successful interventions remain unclear. A qualitative process evaluation of a small scale intervention targeting asthma self-care (the Managing Illness by Empowerment of Self-care and Harmonisation of Patient and Practitioner agenda) MESH intervention) was undertaken as part of my PhD. The analysis revealed three intra-patient processes (illness understanding, affective response to asthma and motivation) and two consultation processes (active patient involvement and individual tailoring) that were associated with change in self-reported asthma self-care behaviour. However, intervention deliverers (nurses) did not always deliver the intervention as intended. Aim: To explore nurses’ experiences of delivering the MESH intervention and, in particular, to identify challenges associated with their ability to deliver it as intended. Design: In-depth qualitative interviews and transcripts of consultations between nurses and patients were analysed using thematic analysis. Participants: Nine nurses with experience in the delivery of asthma care. Setting: Primary care practices in the South West of England. Results: The themes arising from the analysis were (i) experiences of training (ii) perceived usefulness of techniques and approaches (iii) patient motivation and (iv) implementing the MESH in clinical practice Conclusion: This research has identified specific issues relating to nurses’ understanding, motivations and abilities to deliver the MESH intervention. This has important implications for both future health psychology research and clinical practice. With regard to the future development of randomised trials of the MESH intervention, the process of nurse recruitment and training could be adjusted in light of these findings. This will prevent unnecessarily wasting resources and patients’ time, and increase the likely take up and effectiveness of the intervention. Further research is needed to develop theory underpinning nurses’ use of research in clinical practice.
Subjects/Keywords: 616.2; MESH; asthma
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Denford, S. (2014). An analysis of the application of the MESH intervention in asthma. (Doctoral Dissertation). University of the West of England, Bristol. Retrieved from https://uwe-repository.worktribe.com/output/812650 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619063
Chicago Manual of Style (16th Edition):
Denford, Sarah. “An analysis of the application of the MESH intervention in asthma.” 2014. Doctoral Dissertation, University of the West of England, Bristol. Accessed January 18, 2021.
https://uwe-repository.worktribe.com/output/812650 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619063.
MLA Handbook (7th Edition):
Denford, Sarah. “An analysis of the application of the MESH intervention in asthma.” 2014. Web. 18 Jan 2021.
Vancouver:
Denford S. An analysis of the application of the MESH intervention in asthma. [Internet] [Doctoral dissertation]. University of the West of England, Bristol; 2014. [cited 2021 Jan 18].
Available from: https://uwe-repository.worktribe.com/output/812650 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619063.
Council of Science Editors:
Denford S. An analysis of the application of the MESH intervention in asthma. [Doctoral Dissertation]. University of the West of England, Bristol; 2014. Available from: https://uwe-repository.worktribe.com/output/812650 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619063
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