subject:(AMD)

University of Adelaide

1. Orandi, Sanaz. Investigation of algal-microbial biofilms for acid mine drainage treatment.

Degree: 2013, University of Adelaide

► Mining wastewaters, typically acid mine drainage (AMD) have been listed as one of the most severe types of contaminated surface waters containing heavy metals (e.g.… (more)

▼ Mining wastewaters, typically acid mine drainage (AMD) have been listed as one of the most severe types of contaminated surface waters containing heavy metals (e.g. Cu, Zn, Cr, Pb) and toxic metalloids (e.g. As, Cd, Sb). AMD convey these elements into water bodies and threaten aquatic life and human health, consequently. AMD is required to be treated before discharge to the environment, particularly in arid areas with scarce water resources. To date, neutralisation and evaporation have been commonly used at mine sites to decrease the elemental contents of contaminated surface waters. However, these techniques are expensive or ineffective for removing recalcitrant elements e.g. Mn; and produce large volumes of contaminated sludge. In recent decades, the exploitation of microorganisms for treating wastewaters, particularly municipal wastewaters, has significantly improved water treatment technologies, and are referred to as biotreatment/bioremediation. High efficiency, cost effectiveness and sustainability are associated with biotreatment. The application of biotreatment has been investigated for AMD treatment and documented extensively. However, the results are limited and not comprehensive enough for an applicable system to be deployed in mine sites. The main objective of my PhD research was to establish and develop an effective and sustainable AMD biotreatment system for removing metals/metalloids, applicable for mine sites. The indigenous mine microorganisms were used as biosorbents in a biotreatment system, obtained from AMD resources at Sarcheshmeh copper mine, Iran. The microbial sample contained mainly filamentous and unicellular green micro-algae, Klebsomidium sp. and Chlamydomonsae sp.; bacteria, Acidithiobacillus ferroxidance, Leptospirillum ferroxidans and Pseudomonas sp.; and fungi, Aspergillus sp. and Penicillium sp. The AMD, from which the indigenous microbial consortium was collected, was analysed to quantify its cation and anion (including nutrients PO₄⁻³ and NO₃⁻) contents. The analysis data was used to synthesise a multi-ion AMD composed of 25 components (cations and anions at concentrations 0.005-100 mg/L), high sulphate (>1000 mg/L) and low pH (~3). The indigenous microbial assembly was maintained in synthetic AMD (Syn-AMD) in vitro. For the biotreatment investigations, a laboratory-scale photo-rotating biological contactor (PRBC) was designed and used to immobilise the microbial consortium as an algal-microbial biofilm. The PRBC was initially operated in batch mode, using Syn-AMD and indigenous microbes as PRBC solution and inoculum, respectively. An algal-microbial biofilm (60g dry weight) was successfully grown on the discs’ surfaces in the PRBC after 12 weeks. The PRBC was then operated at both batch and continous modes to investigate the efficiency of the system for removing different elements from the Syn-AMD. Batch systems were conducted in 7-day periods under pH 3 and 5. The batch results showed that the algal-microbial biofilm system was able to reduce the concentration of major elements… Advisors/Committee Members: Lewis, David Milton (advisor), Moheimani, Navid R. (advisor), Ashman, Peter John (advisor), School of Chemical Engineering (school).

Subjects/Keywords: AMD; biotreatment; mining; algae; wastewater

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Orandi, S. (2013). Investigation of algal-microbial biofilms for acid mine drainage treatment. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/96471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Orandi, Sanaz. “Investigation of algal-microbial biofilms for acid mine drainage treatment.” 2013. Thesis, University of Adelaide. Accessed March 03, 2021. http://hdl.handle.net/2440/96471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Orandi, Sanaz. “Investigation of algal-microbial biofilms for acid mine drainage treatment.” 2013. Web. 03 Mar 2021.

Vancouver:

Orandi S. Investigation of algal-microbial biofilms for acid mine drainage treatment. [Internet] [Thesis]. University of Adelaide; 2013. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2440/96471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Orandi S. Investigation of algal-microbial biofilms for acid mine drainage treatment. [Thesis]. University of Adelaide; 2013. Available from: http://hdl.handle.net/2440/96471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tampere University

2. Pajukangas, Elias. Silmänpohjan ikärappeuman alueellinen esiintyvyys Suomessa 1998 - 2012 .

Degree: 2015, Tampere University

URL: https://trepo.tuni.fi/handle/10024/98263

► Silmänpohjan ikärappeuma (Age-related Macular Degeneration, AMD, ARMD) on yleisin näkövammaisuuden aiheuttaja länsimaissa, myös Suomessa. Opinnäytetyössäni tarkastelen kyseisen silmäsairauden alueellista esiintyvyyttä ja ilmaantuvuutta Suomessa aikavälillä 1998-2012.… (more)

Subjects/Keywords: Avainsanat: AMD; silmätaudit; näkövammaisuus; näkövammarekisteri

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pajukangas, E. (2015). Silmänpohjan ikärappeuman alueellinen esiintyvyys Suomessa 1998 - 2012 . (Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/98263

Chicago Manual of Style (16^th Edition):

Pajukangas, Elias. “Silmänpohjan ikärappeuman alueellinen esiintyvyys Suomessa 1998 - 2012 .” 2015. Masters Thesis, Tampere University. Accessed March 03, 2021. https://trepo.tuni.fi/handle/10024/98263.

MLA Handbook (7^th Edition):

Pajukangas, Elias. “Silmänpohjan ikärappeuman alueellinen esiintyvyys Suomessa 1998 - 2012 .” 2015. Web. 03 Mar 2021.

Vancouver:

Pajukangas E. Silmänpohjan ikärappeuman alueellinen esiintyvyys Suomessa 1998 - 2012 . [Internet] [Masters thesis]. Tampere University; 2015. [cited 2021 Mar 03]. Available from: https://trepo.tuni.fi/handle/10024/98263.

Council of Science Editors:

Pajukangas E. Silmänpohjan ikärappeuman alueellinen esiintyvyys Suomessa 1998 - 2012 . [Masters Thesis]. Tampere University; 2015. Available from: https://trepo.tuni.fi/handle/10024/98263

Boston University

3. Flynn, Erin Elizabeth. Non-invasive monitoring of lipofuscin: an imaging technique predictive for age-related macular degeneration.

Degree: MS, Medical Sciences, 2016, Boston University

URL: http://hdl.handle.net/2144/19174

► This paper outlines the progression of age-related macular degeneration in the eye and discusses the diagnostic approaches and therapies used currently to treat this disease.… (more)

Subjects/Keywords: Medicine; AMD; Lipofuscin; QAF

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Flynn, E. E. (2016). Non-invasive monitoring of lipofuscin: an imaging technique predictive for age-related macular degeneration. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/19174

Chicago Manual of Style (16^th Edition):

Flynn, Erin Elizabeth. “Non-invasive monitoring of lipofuscin: an imaging technique predictive for age-related macular degeneration.” 2016. Masters Thesis, Boston University. Accessed March 03, 2021. http://hdl.handle.net/2144/19174.

MLA Handbook (7^th Edition):

Flynn, Erin Elizabeth. “Non-invasive monitoring of lipofuscin: an imaging technique predictive for age-related macular degeneration.” 2016. Web. 03 Mar 2021.

Vancouver:

Flynn EE. Non-invasive monitoring of lipofuscin: an imaging technique predictive for age-related macular degeneration. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2144/19174.

Council of Science Editors:

Flynn EE. Non-invasive monitoring of lipofuscin: an imaging technique predictive for age-related macular degeneration. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/19174

University of Southern California

4. He, Lijun. The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population.

Degree: MS, Biostatistics, 2014, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225

► The Latino population is an admixed population. Previous studies indicate the potential role of ethnicity in the risk of AMD. The purpose of this study… (more)

▼ The Latino population is an admixed population. Previous studies indicate the potential role of ethnicity in the risk of AMD. The purpose of this study is to evaluate the effect of population structure on the association between the risk of AMD and Single Nucleotide Polymorphisms (SNPs). ❧ The Los Angeles Latino Eye Study (LALES) is a unique population‐based cohort study designed to explore eye diseases in the Los Angeles Latino population. 1007 Mexican Americans aged 40 years and older, including 490 subjects with AMD and 517 corresponding controls, were selected from the LALES population. DNA was extracted for all subjects using blood cards. Genotyping of these DNA samples was performed using the Illumina HumanOmniExpress BeadChip. Genotypes of 988 HapMap samples and 88 Native American samples were also included in our study as reference groups for ancestry estimation. ❧ The PLINK and R software packages are used for data analysis. Panels with 243 ancestry informative markers, and others with a range of different numbers of randomly selected SNPs, are used to estimate global ancestry. This global ancestry analysis is performed using the software STRUCTURE and EIGENSTRAT. Logistic regression is used to evaluate the effect of the global ancestry estimates on subsequent association testing. The software Haploview is used to demonstrate the results of Genome Wide Association Study (GWAS). Correlation coefficient r² is computed to assess the methods used to estimate the genetic ancestry and the effect of population stratification. ❧ The average genetic ancestry for individuals from the LALES population is around 52.4% European, 43.5% Native American, 3.8% African, and 0.3% Asian. The results from logistic regression and GWAS indicate that there is no effect of population stratification on the relationship between risk of AMD and SNPs. Advisors/Committee Members: Azen, Stanley P.Marjoram, Paul (Committee Chair), Gauderman, William James (Committee Member).

Subjects/Keywords: ancestry analysis; Latino population; AMD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

He, L. (2014). The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225

Chicago Manual of Style (16^th Edition):

He, Lijun. “The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population.” 2014. Masters Thesis, University of Southern California. Accessed March 03, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225.

MLA Handbook (7^th Edition):

He, Lijun. “The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population.” 2014. Web. 03 Mar 2021.

Vancouver:

He L. The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population. [Internet] [Masters thesis]. University of Southern California; 2014. [cited 2021 Mar 03]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225.

Council of Science Editors:

He L. The role of genetic ancestry in estimation of the risk of age-related degeneration (AMD) in the Los Angeles Latino population. [Masters Thesis]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/457444/rec/7225

University of Sydney

5. Munoz-Erazo, Luis Enrique. Cellular Responses of the Retina to West Nile Virus Infection .

Degree: 2016, University of Sydney

URL: http://hdl.handle.net/2123/15404

► Age-related macular degeneration (AMD) is the leading cause of blindness in the developing world in people aged over 60 years, manifested as a loss of… (more)

▼ Age-related macular degeneration (AMD) is the leading cause of blindness in the developing world in people aged over 60 years, manifested as a loss of central vision in one or both eyes, with significant morbidity including loss of mobility and depression. This condition involves the degeneration of the macula, and although the exact aetiology of this disease is unknown, various epidemiological studies have shown it to be multifactorial. Current research points towards the involvement of a dysregulated immune system in the pathogenesis and progression of the disease: as the body ages, the immune system increasingly adopts a more inflammatory basal state. However, not all of the aged population develops AMD and it is highly likely that an additional stimulus or stimuli is/are needed to exploit this dysregulated immune environment to initiate this disease. Given the range of pathogens that can infect the retina, we hypothesize that this breaking point could manifest as a chronic inflammation as a result of a low-level infection. West Nile Virus (WNV) is a flavivirus that has come into international prominence ever since its spread into previously WNV-free regions following the 1999 New York outbreak. As several case reports have shown that WNV is capable of infecting the retina, and given its immunopathogenic properties, we believe the virus is a useful tool to model key immune pathways and responses that may be involved in the development and progression of AMD. Of significant interest are the processes involved in the breakdown of the outer blood-retinal barrier (BRB), which is an important step in the progression of AMD from an early stage to a more severe one. Additionally, deciphering and understanding the profile and populations of leukocytes that are recruited during an immunopathic infection in an organ regarded as being immunoprivileged is of great appeal. With this in mind, we set out to investigate the effects of WNV infection on the retinal pigment epithelium (RPE), which comprises the outer BRB. Previously, our laboratory established the WNV BRB model by quantitating various parameters, such as level of infectivity, viral output by WNV-infected RPE and effects of WNV infection on RPE proliferation/migration. The effect of WNV on the extracellular matrix (ECM) production by RPE was also investigated and increases in collagen I, IV and fibronectin were noted. Global ECM production induced a lowered rate of proliferation of RPE seeded on WNV-infected RPE ECM as opposed to mock-infected ECM. A full genome microarray was also undertaken on WNV-infected RPE to analyse differentially regulated gene mRNA production, and increases in several immune genes, as well as genes involved in the stress-response pathway and the TGFβ pathway were found. This current investigation expanded upon these results, and found that WNV infection produces a predominantly CCL5 chemokine response rather than a CCL2 response. Additionally, a lack of TNF production was noted, despite a high initial upregulation of the TNF gene in…

Subjects/Keywords: AMD; WNV; retina; immunopathology; intravitreal

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Munoz-Erazo, L. E. (2016). Cellular Responses of the Retina to West Nile Virus Infection . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/15404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Munoz-Erazo, Luis Enrique. “Cellular Responses of the Retina to West Nile Virus Infection .” 2016. Thesis, University of Sydney. Accessed March 03, 2021. http://hdl.handle.net/2123/15404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Munoz-Erazo, Luis Enrique. “Cellular Responses of the Retina to West Nile Virus Infection .” 2016. Web. 03 Mar 2021.

Vancouver:

Munoz-Erazo LE. Cellular Responses of the Retina to West Nile Virus Infection . [Internet] [Thesis]. University of Sydney; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2123/15404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Munoz-Erazo LE. Cellular Responses of the Retina to West Nile Virus Infection . [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/15404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tokyo Institute of Technology / 東京工業大学

6. Hsu, Wei-Lin. Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations : Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations.

Degree: 博士（工学）, 2016, Tokyo Institute of Technology / 東京工業大学

URL: http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100711995

► ATP-binding cassette (ABC) transporters are able to translocate various substrates across cell membranes, and thus considered clinically important. However, the detailed translocation mechanism still remains… (more)

Subjects/Keywords: ABC transporter; metadynamics; maltose transporter; aMD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hsu, W. (2016). Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations : Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations. (Thesis). Tokyo Institute of Technology / 東京工業大学. Retrieved from http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100711995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hsu, Wei-Lin. “Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations : Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations.” 2016. Thesis, Tokyo Institute of Technology / 東京工業大学. Accessed March 03, 2021. http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100711995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hsu, Wei-Lin. “Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations : Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations.” 2016. Web. 03 Mar 2021.

Vancouver:

Hsu W. Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations : Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations. [Internet] [Thesis]. Tokyo Institute of Technology / 東京工業大学; 2016. [cited 2021 Mar 03]. Available from: http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100711995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsu W. Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations : Elucidation of functionally important dynamics and structural changes of the E. coli maltose transporter by all-atom molecular dynamics simulations. [Thesis]. Tokyo Institute of Technology / 東京工業大学; 2016. Available from: http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100711995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

7. Akella, Sudheer. A novel association between serum bilirubin levels and age-related macular degeneration.

Degree: MS, Medical Sciences, 2014, Boston University

URL: http://hdl.handle.net/2144/14688

► The purpose of this study is to examine the association between serum bilirubin and the development of age-related macular degeneration (AMD). The study design includes… (more)

Subjects/Keywords: Ophthalmology; Age-related macular degeneration; AMD; Bilirubin

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Akella, S. (2014). A novel association between serum bilirubin levels and age-related macular degeneration. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14688

Chicago Manual of Style (16^th Edition):

Akella, Sudheer. “A novel association between serum bilirubin levels and age-related macular degeneration.” 2014. Masters Thesis, Boston University. Accessed March 03, 2021. http://hdl.handle.net/2144/14688.

MLA Handbook (7^th Edition):

Akella, Sudheer. “A novel association between serum bilirubin levels and age-related macular degeneration.” 2014. Web. 03 Mar 2021.

Vancouver:

Akella S. A novel association between serum bilirubin levels and age-related macular degeneration. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2144/14688.

Council of Science Editors:

Akella S. A novel association between serum bilirubin levels and age-related macular degeneration. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14688

University of Manchester

8. Haneef, Atikah Shahid. Fabrication of novel cytocompatible membranes for ocular application, concentrating in particular on age-related macular degeneration (AMD).

Degree: PhD, 2014, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/fabrication-of-novel-cytocompatible-membranes-for-ocular-application-concentrating-in-particular-on-agerelated-macular-degeneration-amd(7d1ace68-09d8-4c64-83e7-3ede1e2f52e1).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626896

► The aims of this research were to investigate polymer fibre morphology, overall mat morphology, mechanical properties and general handling of the mats, and ideal mat… (more)

▼ The aims of this research were to investigate polymer fibre morphology, overall mat morphology, mechanical properties and general handling of the mats, and ideal mat thickness in order to fabricate a suitable substrate for potential use in cell transplantation for application as a permanent substrate for the treatment of dry age-related macular degeneration (AMD). Polystyrene (PS), poly(ethylene terephthalate) (PET) and polyurethane (PU) were electrospun to ascertain the ideal electrospinning parameters to reproducibly obtain fibres to construct a mat as a potential candidate for a replacement Bruch’s membrane (BM). After identifying the ideal spinning parameters, mats were fabricated, their fibre morphology, overall mat morphology, and handling during processing were examined. This allowed the shortlisting of PS and PET substrates, which were suitable to be taken forward for further testing and cell culture. PU was found to be unsuitable as it had a tendency to become entwined and stick to itself, which would destroy the gross mat morphology. Therefore PU was excluded from further testing. Further handling, both quantitative and qualitative, and thickness and porosity were tested for PS and PET mats. Electrospun PET demonstrated greater handling and durability properties compared to PS mats, which were more fragile. PET was able to withstand twisting, folding, and rolling, whereas PS could not undergo twisting and fell apart. PS mats were thicker and more porous compared to PET mats, which was attributed to the widely spaced placement of the larger PS fibres and the fluffy gross morphology of the PS mats, in comparison to the closer fibre placement of the smaller PET mats which had a smooth gross mat morphology. Considering this, PS mats were compressed and thickness and porosity was reduced, while maintaining its fibrous structure. However the compressed PS mats became extremely fragile and could not withstand much handling. Although PET mats were thinner than PS mats, it did not match the native BM thickness and so experiments in varying collection time during electrospinning to match the native BM thickness were undertaken. Tensile tests, thickness and porosity measurements showed that PET tensile properties, thickness, and porosity reduced with reduced collection time. For the purposes of surface treatment and cell culture, uncompressed mats collected for 60 minutes were used since sufficient PS fibres were able to be collected to form a mat that was able to withstand processing at this collection time. Effect of UV/ozone surface treatment was tested for both PS and PET mats. Treatment of both substrate types affected protein adsorption, with evidence of aminolysis observed on PET substrates. Short-term initial growth and survival of retinal pigment epithelial cells (RPE cells) on electrospun, surface oxidised PS and PET was investigated. Untreated PS did not support cell proliferation and although treated PS did, the resultant RPE cell morphology was undesirable, therefore was not taken forward to long term…

Subjects/Keywords: 617.7; AMD; Bruch's membrane; Electrospinning; ARPE-19

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haneef, A. S. (2014). Fabrication of novel cytocompatible membranes for ocular application, concentrating in particular on age-related macular degeneration (AMD). (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/fabrication-of-novel-cytocompatible-membranes-for-ocular-application-concentrating-in-particular-on-agerelated-macular-degeneration-amd(7d1ace68-09d8-4c64-83e7-3ede1e2f52e1).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626896

Chicago Manual of Style (16^th Edition):

Haneef, Atikah Shahid. “Fabrication of novel cytocompatible membranes for ocular application, concentrating in particular on age-related macular degeneration (AMD).” 2014. Doctoral Dissertation, University of Manchester. Accessed March 03, 2021. https://www.research.manchester.ac.uk/portal/en/theses/fabrication-of-novel-cytocompatible-membranes-for-ocular-application-concentrating-in-particular-on-agerelated-macular-degeneration-amd(7d1ace68-09d8-4c64-83e7-3ede1e2f52e1).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626896.

MLA Handbook (7^th Edition):

Haneef, Atikah Shahid. “Fabrication of novel cytocompatible membranes for ocular application, concentrating in particular on age-related macular degeneration (AMD).” 2014. Web. 03 Mar 2021.

Vancouver:

Haneef AS. Fabrication of novel cytocompatible membranes for ocular application, concentrating in particular on age-related macular degeneration (AMD). [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Mar 03]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/fabrication-of-novel-cytocompatible-membranes-for-ocular-application-concentrating-in-particular-on-agerelated-macular-degeneration-amd(7d1ace68-09d8-4c64-83e7-3ede1e2f52e1).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626896.

Council of Science Editors:

Haneef AS. Fabrication of novel cytocompatible membranes for ocular application, concentrating in particular on age-related macular degeneration (AMD). [Doctoral Dissertation]. University of Manchester; 2014. Available from: https://www.research.manchester.ac.uk/portal/en/theses/fabrication-of-novel-cytocompatible-membranes-for-ocular-application-concentrating-in-particular-on-agerelated-macular-degeneration-amd(7d1ace68-09d8-4c64-83e7-3ede1e2f52e1).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626896

Michigan Technological University

9. Sripathi, Srinivasa Rao. BIOCHEMICAL AND CELLULAR MECHANISMS OF RETINA AND RETINAL PIGMENT EPITHELIUM APOPTOSIS.

Degree: PhD, Department of Biological Sciences, 2013, Michigan Technological University

URL: https://digitalcommons.mtu.edu/etds/581

► Oxidative stress, intense light exposure and oxygen imbalances such as hypoxic or hyperoxic conditions perturb mitochondria, nuclear function and further lead to cellular damage… (more)

▼ Oxidative stress, intense light exposure and oxygen imbalances such as hypoxic or hyperoxic conditions perturb mitochondria, nuclear function and further lead to cellular damage of retina and retinal pigment epithelial (RPE) cells. Our major aim is to understand the various biochemical and proteomic events that occur during the progression of retina and RPE cell death. The comprehensive objectives of this dissertation are to understand the functional aspects of protein expression, posttranslational modifications, protein or lipid binding changes, phenotypic, morphological alterations and their regulation during the retina and RPE apoptosis under oxidative stress. The entire study is divided into four chapters Chapter 1 contains introduction and background on apoptotic signaling in retina and RPE cells. In chapter 2, we demonstrated that the oxidative stress biomarker prohibitin shuttles between mitochondria and nucleus as an anti-apoptotic molecule and acts as a transcriptional regulator by altering its lipid binding affinity and by posttranslational modifications during oxidative damage to the retina and RPE. In chapter 3, we demonstrated that oxidative and photo-oxidative stress induced nitric oxide regulates the RPE apoptosis by altering serine/threonine protein phosphatase 2A (PP2A) catalytic subunit, vimentin phosphorylation and Bcl xL expression regulation in the RPE cells in vitro. In chapter 4, we further analyzed the differential expression of prohibitin in the retina and RPE during oxidative stress, diabetic retinopathy (DR) and age-related macular degeneration (AMD) condition. Our analysis of postmortem retinas reveals that prohibitin is significantly increased in aged and AMD retina, and decreased in retinas of human diabetic retinopathy and RPE of AMD. Our study demonstrates that prohibitin levels determine the apoptotic signaling in the retina and RPE during retinal degenerative disease progression. Advisors/Committee Members: Wan Jin Jahng, Ramakrishna Wusirika.

Subjects/Keywords: AMD; apoptosis; oxidative stress; Retina; RPE; Biochemistry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sripathi, S. R. (2013). BIOCHEMICAL AND CELLULAR MECHANISMS OF RETINA AND RETINAL PIGMENT EPITHELIUM APOPTOSIS. (Doctoral Dissertation). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etds/581

Chicago Manual of Style (16^th Edition):

Sripathi, Srinivasa Rao. “BIOCHEMICAL AND CELLULAR MECHANISMS OF RETINA AND RETINAL PIGMENT EPITHELIUM APOPTOSIS.” 2013. Doctoral Dissertation, Michigan Technological University. Accessed March 03, 2021. https://digitalcommons.mtu.edu/etds/581.

MLA Handbook (7^th Edition):

Sripathi, Srinivasa Rao. “BIOCHEMICAL AND CELLULAR MECHANISMS OF RETINA AND RETINAL PIGMENT EPITHELIUM APOPTOSIS.” 2013. Web. 03 Mar 2021.

Vancouver:

Sripathi SR. BIOCHEMICAL AND CELLULAR MECHANISMS OF RETINA AND RETINAL PIGMENT EPITHELIUM APOPTOSIS. [Internet] [Doctoral dissertation]. Michigan Technological University; 2013. [cited 2021 Mar 03]. Available from: https://digitalcommons.mtu.edu/etds/581.

Council of Science Editors:

Sripathi SR. BIOCHEMICAL AND CELLULAR MECHANISMS OF RETINA AND RETINAL PIGMENT EPITHELIUM APOPTOSIS. [Doctoral Dissertation]. Michigan Technological University; 2013. Available from: https://digitalcommons.mtu.edu/etds/581

University of Iowa

10. Schindler, Emily Isaak. Genetics of inherited retinal degeneration.

Degree: PhD, Genetics, 2011, University of Iowa

URL: https://ir.uiowa.edu/etd/1075

► Heritable retinal degenerations dramatically affect individuals across the lifespan. Heritable degenerations with onset in childhood or young adulthood, such as the ABCA4- associated maculopathies,… (more)

Subjects/Keywords: ABCA4; AMD; eye; retina; SNP; Stargardt; Genetics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schindler, E. I. (2011). Genetics of inherited retinal degeneration. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/1075

Chicago Manual of Style (16^th Edition):

Schindler, Emily Isaak. “Genetics of inherited retinal degeneration.” 2011. Doctoral Dissertation, University of Iowa. Accessed March 03, 2021. https://ir.uiowa.edu/etd/1075.

MLA Handbook (7^th Edition):

Schindler, Emily Isaak. “Genetics of inherited retinal degeneration.” 2011. Web. 03 Mar 2021.

Vancouver:

Schindler EI. Genetics of inherited retinal degeneration. [Internet] [Doctoral dissertation]. University of Iowa; 2011. [cited 2021 Mar 03]. Available from: https://ir.uiowa.edu/etd/1075.

Council of Science Editors:

Schindler EI. Genetics of inherited retinal degeneration. [Doctoral Dissertation]. University of Iowa; 2011. Available from: https://ir.uiowa.edu/etd/1075

University of Edinburgh

11. Stanton, Chloe May. Investigating the genetic and molecular basis of age-related macular degeneration.

Degree: PhD, 2012, University of Edinburgh

URL: http://hdl.handle.net/1842/9608

► Age-related macular degeneration (AMD) is the leading cause of blindness worldwide, affecting an estimated 50 million individuals aged over 65 years. Environmental and genetic risk-factors… (more)

▼ Age-related macular degeneration (AMD) is the leading cause of blindness worldwide, affecting an estimated 50 million individuals aged over 65 years. Environmental and genetic risk-factors contribute to the development of AMD. An AMD-risk locus on chromosome 10q26 spans two genes, ARMS2 and HTRA1, and controversy exists as to which variants are responsible for increased risk of disease. Recent work suggests that HTRA1 expression levels are significantly increased in carriers of the risk haplotype associated with AMD. However, relatively little is known about the interactions, substrate specificity and roles in disease played by this secreted serine protease. This thesis aims to elucidate the potential role played by HTRA1 in AMD pathogenesis. A combination of tandem affinity purification (TAP) and yeast two-hybrid techniques was used to identify interacting partners of HTRA1. A number of proteins, with diverse roles in the alternative complement pathway, cell signaling, cell-matrix interactions, inflammation, angiogenesis and fibrosis, were identified. These are attractive candidates for further study as such processes are disturbed in AMD, implicating HTRA1 and its binding partners in disease development. One interacting partner, Complement Factor D (CFD), is a key activator in the alternative complement pathway. CFD, a 24 kDa serine protease, is expressed as an inactive zymogen, from which a signal peptide and activation peptide are cleaved before release of the mature, active protein into the circulation. In vitro studies show that CFD interacts with, and can be a substrate for, HTRA1. The interacting domain between the two proteins is localised to a region of 30 amino acids at the N-terminal end of proCFD. The 5 amino acid pro-peptide of CFD appears to be both necessary and sufficient for proteolysis of CFD by HTRA1. Investigation of the functional relevance of the interaction between HTRA1 and CFD shows that proCFD is cleaved by HTRA1, whilst mature CFD is not subjected to proteolysis. HTRA1-mediated cleavage of CFD forms an active protease, leading to activation of factor B in the alternative complement pathway in in vitro assays. Furthermore, a normal complement response is restored to CFD-depleted serum by addition of proCFD activated by HTRA1. Thus, an HTRA1- mediated increase in alternative complement pathway activity may explain a proportion of the AMD-risk attributed to the chr10q26 locus. Genetic and protein-based approaches were used to study the potential role of CFD in AMD pathogenesis, independent of an interaction with HTRA1. An intronic SNP, rs3826945, was significantly associated with increased risk of AMD in two British case-control cohorts, and in a combined meta-analysis with 4 additional cohorts from North America and Europe (p-value = 0.032, Odds Ratio = 1.112 in 4765 cases and 2693 controls). Assessment of copy number variation and sequencing of CFD did not identify any functional variants which may explain the association with disease. However, plasma levels of CFD were measured by ELISA in…

Subjects/Keywords: 617.7; Age-related macular degeneration; AMD; HTRA1

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stanton, C. M. (2012). Investigating the genetic and molecular basis of age-related macular degeneration. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/9608

Chicago Manual of Style (16^th Edition):

Stanton, Chloe May. “Investigating the genetic and molecular basis of age-related macular degeneration.” 2012. Doctoral Dissertation, University of Edinburgh. Accessed March 03, 2021. http://hdl.handle.net/1842/9608.

MLA Handbook (7^th Edition):

Stanton, Chloe May. “Investigating the genetic and molecular basis of age-related macular degeneration.” 2012. Web. 03 Mar 2021.

Vancouver:

Stanton CM. Investigating the genetic and molecular basis of age-related macular degeneration. [Internet] [Doctoral dissertation]. University of Edinburgh; 2012. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1842/9608.

Council of Science Editors:

Stanton CM. Investigating the genetic and molecular basis of age-related macular degeneration. [Doctoral Dissertation]. University of Edinburgh; 2012. Available from: http://hdl.handle.net/1842/9608

University of Manchester

12. Haneef, Atikah Shahid. Fabrication of Novel Cytocompatible Membranes for Ocular Application, Concentrating in Particular on Age-Related Macular Degeneration (AMD).

Degree: 2014, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230947

► AbstractThe University of ManchesterAtikah Shahid HaneefDoctor of Philosophy (PhD)Fabrication of Novel Cytocompatible Membranes for Ocular Application, Concentrating in Particular on Age-Related Macular Degeneration (AMD)April 2014The… (more)

▼ AbstractThe University of ManchesterAtikah Shahid HaneefDoctor of Philosophy (PhD)Fabrication of Novel Cytocompatible Membranes for Ocular Application, Concentrating in Particular on Age-Related Macular Degeneration (AMD)April 2014The aims of this research were to investigate polymer fibre morphology, overall mat morphology, mechanical properties and general handling of the mats, and ideal mat thickness in order to fabricate a suitable substrate for potential use in cell transplantation for application as a permanent substrate for the treatment of dry age-related macular degeneration (AMD). Polystyrene (PS), poly(ethylene terephthalate) (PET) and polyurethane (PU) were electrospun to ascertain the ideal electrospinning parameters to reproducibly obtain fibres to construct a mat as a potential candidate for a replacement Bruch’s membrane (BM). After identifying the ideal spinning parameters, mats were fabricated, their fibre morphology, overall mat morphology, and handling during processing were examined. This allowed the shortlisting of PS and PET substrates, which were suitable to be taken forward for further testing and cell culture. PU was found to be unsuitable as it had a tendency to become entwined and stick to itself, which would destroy the gross mat morphology. Therefore PU was excluded from further testing.Further handling, both quantitative and qualitative, and thickness and porosity were tested for PS and PET mats. Electrospun PET demonstrated greater handling and durability properties compared to PS mats, which were more fragile. PET was able to withstand twisting, folding, and rolling, whereas PS could not undergo twisting and fell apart. PS mats were thicker and more porous compared to PET mats, which was attributed to the widely spaced placement of the larger PS fibres and the fluffy gross morphology of the PS mats, in comparison to the closer fibre placement of the smaller PET mats which had a smooth gross mat morphology. Considering this, PS mats were compressed and thickness and porosity was reduced, while maintaining its fibrous structure. However the compressed PS mats became extremely fragile and could not withstand much handling. Although PET mats were thinner than PS mats, it did not match the native BM thickness and so experiments in varying collection time during electrospinning to match the native BM thickness were undertaken. Tensile tests, thickness and porosity measurements showed that PET tensile properties, thickness, and porosity reduced with reduced collection time.For the purposes of surface treatment and cell culture, uncompressed mats collected for 60 minutes were used since sufficient PS fibres were able to be collected to form a mat that was able to withstand processing at this collection time. Effect of UV/ozone surface treatment was tested for both PS and PET mats. Treatment of both substrate types affected protein adsorption, with evidence of aminolysis observed on PET substrates. Short-term initial growth and survival of retinal pigment epithelial cells (RPE cells) on… Advisors/Committee Members: Downes, Sandra.

Subjects/Keywords: AMD; Bruch's membrane; Electrospinning; ARPE-19

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haneef, A. S. (2014). Fabrication of Novel Cytocompatible Membranes for Ocular Application, Concentrating in Particular on Age-Related Macular Degeneration (AMD). (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230947

Chicago Manual of Style (16^th Edition):

Haneef, Atikah Shahid. “Fabrication of Novel Cytocompatible Membranes for Ocular Application, Concentrating in Particular on Age-Related Macular Degeneration (AMD).” 2014. Doctoral Dissertation, University of Manchester. Accessed March 03, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230947.

MLA Handbook (7^th Edition):

Haneef, Atikah Shahid. “Fabrication of Novel Cytocompatible Membranes for Ocular Application, Concentrating in Particular on Age-Related Macular Degeneration (AMD).” 2014. Web. 03 Mar 2021.

Vancouver:

Haneef AS. Fabrication of Novel Cytocompatible Membranes for Ocular Application, Concentrating in Particular on Age-Related Macular Degeneration (AMD). [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Mar 03]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230947.

Council of Science Editors:

Haneef AS. Fabrication of Novel Cytocompatible Membranes for Ocular Application, Concentrating in Particular on Age-Related Macular Degeneration (AMD). [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:230947

University of Sydney

13. Broadhead, Geoffrey Kenneth. Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration .

Degree: 2015, University of Sydney

URL: http://hdl.handle.net/2123/14720

► Purpose: To assess the efficacy of two therapies, intravitreal aflibercept and oral saffron supplementation, for the treatment of different aspects of age-related macular degeneration (AMD).… (more)

▼ Purpose: To assess the efficacy of two therapies, intravitreal aflibercept and oral saffron supplementation, for the treatment of different aspects of age-related macular degeneration (AMD). Methods: Two prospective clinical trials were conducted, i) one open label, single arm trial investigating intravitreal aflibercept for the management of treatment-resistant neovascular AMD, and ii) the other a randomised control trial investigating oral saffron supplementation for the treatment of intermediate AMD. Outcomes assessed included: mean change in mfERG response, mean change in individual mfERG ring response, mean change in BCVA and safety of saffron as compared to placebo. Results: i) The mean gain in BCVA was 6.7 and 4.7 letters at 6 and 12 months respectively (p<0.001), and the mean reduction in CMT was 100.0 µm at 6 and 12 months respectively. ii) Saffron supplementation was associated with a 2.1% increase in overall mfERG response (p=0.08) and a 0.69 letter increase in BCVA (p=0.001) compared to placebo. In those patients on AREDS supplements, saffron was associated with an increase of 2.8% in mfERG and an increase in BCVA of 0.73 letters (p<0.05 for both). There was no significant difference in adverse event frequency (overall or by subtype) whilst on saffron as compared to placebo. Conclusions: i) Intravitreal aflibercept was an effective therapy for the management of treatment-resistant neovascular AMD. The efficacy of aflibercept waned slightly over time, and further research is needed on the long-term effects of anti-VEGF agents. ii) Oral saffron was effective in improving visual outcomes in patients with intermediate AMD, including those on current standard of care therapy (AREDS supplement or equivalent), suggesting that oral saffron may offer additional benefit. Given the considerable burden that AMD imposes on sufferers and the health-care system in general, further consideration and research should be conducted into the role of saffron as therapy for AMD.

Subjects/Keywords: Age-related macular degeneration (AMD); Aflibercept; Saffron

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Broadhead, G. K. (2015). Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/14720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Broadhead, Geoffrey Kenneth. “Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration .” 2015. Thesis, University of Sydney. Accessed March 03, 2021. http://hdl.handle.net/2123/14720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Broadhead, Geoffrey Kenneth. “Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration .” 2015. Web. 03 Mar 2021.

Vancouver:

Broadhead GK. Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration . [Internet] [Thesis]. University of Sydney; 2015. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2123/14720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Broadhead GK. Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration . [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/14720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

14. Ly, Angelica. Multimodal imaging in age-related macular degeneration.

Degree: Optometry & Vision Science, 2018, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true

► Age-related macular degeneration (AMD) is a leading cause of blindness and affects approximately one in sevenAustralians aged 50 years and above. Currently, this complex condition… (more)

▼ Age-related macular degeneration (AMD) is a leading cause of blindness and affects approximately one in sevenAustralians aged 50 years and above. Currently, this complex condition is not easily and uniformly assessed. Thesigns of AMD differ between eyes and also occur in other macular disorders. This hinders accurate diagnosis andclassification, which is fundamental to optimal patient care. Ocular imaging and visual function assessment have thepotential to minimise the devastating consequences of disease through early detection. However, multiple devicesare now commercially available and the impact of these technologies in clinical practice may not be straightforward.For instance, their usefulness may depend on accessibility and the operator’s knowledge and clinical skills. Theimpact on patient management, as well as alternative models of eye-care delivery, requires clarification.This thesis aims to explore the current and potential utility of imaging technologies (optical coherence tomography,infrared imaging, monochromatic retinal photography and fundus autofluorescence) in the assessment andmanagement of AMD and other diseases of retinal pigment epithelium dysfunction.The findings show that optometrists self-describe high levels of practice competency and make ready use of imagingin everyday practice. However, they also unwittingly demonstrated low awareness of the evidence base in AMD.Furthermore, when their interpretation of images was tested using a series of case vignettes, their diagnosticaccuracy as a group improved by only five per cent (from 61 per cent to 66 per cent); their tendency to referincreased by four per cent. These factors might be improved through education.A series of open-access, chair-side reference charts were consequently devised to help optometrists use imagingtechnologies more effectively in clinical practice. The additive contribution of multimodal structural and functionaltesting was particularly emphasised. Finally, a novel model of intermediate-tier eye-care in Australia was shown tosubstantially reduce the number of false positive cases or cases without a specific diagnosis. Interestingly, this modelwas acclaimed by reviewers as “scoring highly for originality and of international relevance”. Most excitingly, thethesis concludes with future directions regarding collaborative care and multimodal imaging, where detection ofdisease might be facilitated via a computational approach. Advisors/Committee Members: Kalloniatis, Michael, Optometry & Vision Science, Faculty of Science, UNSW, Nivison-Smith, Lisa, Optometry & Vision Science, Faculty of Science, UNSW.

Subjects/Keywords: Multimodal imaging; Age-related macular degeneration (AMD)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ly, A. (2018). Multimodal imaging in age-related macular degeneration. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Ly, Angelica. “Multimodal imaging in age-related macular degeneration.” 2018. Doctoral Dissertation, University of New South Wales. Accessed March 03, 2021. http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Ly, Angelica. “Multimodal imaging in age-related macular degeneration.” 2018. Web. 03 Mar 2021.

Vancouver:

Ly A. Multimodal imaging in age-related macular degeneration. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Mar 03]. Available from: http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true.

Council of Science Editors:

Ly A. Multimodal imaging in age-related macular degeneration. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true

University of Oklahoma

15. Oxenford, Leah. Iron Transport and Removal Dynamics in the Oxidative Units of a Passive Treatment System.

Degree: PhD, 2016, University of Oklahoma

URL: http://hdl.handle.net/11244/47119

► Abstract Mine drainage is threat to water systems in legacy mining districts as elevated concentrations of dissolved iron, sulfate, and trace metals have an unmitigated… (more)

▼ Abstract Mine drainage is threat to water systems in legacy mining districts as elevated concentrations of dissolved iron, sulfate, and trace metals have an unmitigated impact on water quality. Changes in pH due to acidity loading as well as the mobilization of trace metals poses an unacceptable risk to environmental and human health. A variety of active remediation strategies exist, but differ in their initial capital investment, operational requirements, and maintenance making them less attractive options for remote or abandoned locations due to cost. Passive treatment systems (PTS) have become an increasingly more popular technology for the treatment of acid mine drainage (AMD) with the goal of improving water quality through (1) acid neutralization, (2) metals removal and retention and (3) alkalinity generation. Passive treatment systems are composed of a series of treatment cells, in which each unit is designed to meet one or more of the afore mentioned goals through the control of physical, chemical, and biological aspects of the treatment cells. The preliminary oxidation cells of a passive treatment system focus on the removal and retention of iron specifically due to its roll in physical (solids accumulation and retention to maintain hydraulic conductivity through the system), chemical (latent acidity produced via oxidation and hydrolysis; trace metals sorption to FeOOH(s)), and biological (use of emergent hydrophytes to facilitate solids sedimentation) system functions. The premise of this dissertation is that passive treatment system performance is dependent on the dynamic removal, fate, and transport of iron oxides over time. The following chapters each contribute to a detailed assessment of the design and performance of the oxidative unit of a full scale passive treatment system under expected (design driven) operational conditions and under periods of disturbance due to frequent storm activity. The performance of the oxidative unit, and the performance of the system overall for the first seven years of operation are addressed through intracellular transport, removal, and accumulation profiling. Chapter One, “Full Scale Passive Treatment of Net-Alkaline Ferruginous Acid Mine Drainage at the Tar Creek Superfund Site” describes the need for site specific passive treatment, and the critical decisions involved in treatment system design. This chapter represents data as a collaborative work of monitoring by the Center for the Restoration of Ecosystems and Watersheds over a period of nearly 10 years (2004-2015) leading up to the installation and application of full scale treatment technologies in fall of 2008, and their performance evaluation over the next seven years of operation to assess effectiveness in achieving the goal of water quality improvement. The Mayer Ranch Passive Treatment system meets water quality improvement expectations as seep concentrations of iron (192 mg/L), zinc (9.78 mg/L), nickel (0.933 mg/L), cadmium (15.1 µg/L), lead (60 µg/L) and arsenic (66 µg/L) are attenuated prior to… Advisors/Committee Members: Nairn, Robert (advisor), Strevett, Keith, David, Elizabeth, Andrew, Robert Sabatini, Butler, Madden, Nairn (committee member).

Subjects/Keywords: AMD Iron Oxidation Removal Profiling Tar Creek

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oxenford, L. (2016). Iron Transport and Removal Dynamics in the Oxidative Units of a Passive Treatment System. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/47119

Chicago Manual of Style (16^th Edition):

Oxenford, Leah. “Iron Transport and Removal Dynamics in the Oxidative Units of a Passive Treatment System.” 2016. Doctoral Dissertation, University of Oklahoma. Accessed March 03, 2021. http://hdl.handle.net/11244/47119.

MLA Handbook (7^th Edition):

Oxenford, Leah. “Iron Transport and Removal Dynamics in the Oxidative Units of a Passive Treatment System.” 2016. Web. 03 Mar 2021.

Vancouver:

Oxenford L. Iron Transport and Removal Dynamics in the Oxidative Units of a Passive Treatment System. [Internet] [Doctoral dissertation]. University of Oklahoma; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11244/47119.

Council of Science Editors:

Oxenford L. Iron Transport and Removal Dynamics in the Oxidative Units of a Passive Treatment System. [Doctoral Dissertation]. University of Oklahoma; 2016. Available from: http://hdl.handle.net/11244/47119

University of Toledo Health Science Campus

16. Alzhrani, Rami Mohammed. Tanshinone IIA Inhibits VEGF Secretion and HIF-1a Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia.

Degree: MSP, Pharmaceutical Sciences (Industrial Pharmacy), 2016, University of Toledo Health Science Campus

URL: http://rave.ohiolink.edu/etdc/view?acc_num=mco1468407344

► Purpose: The current work intends to study the activity of tanshinone IIA on secretion ofVEGF and expression of HIF-1a in human retinal pigment epithelial cells… (more)

Subjects/Keywords: Pharmacy Sciences; Alternative Medicine; AMD, ARMD, Inhibition of HIF-1a and VEGF in AMD, Tanshinone IIA inhibits HIF-1a and VEGF in AMD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alzhrani, R. M. (2016). Tanshinone IIA Inhibits VEGF Secretion and HIF-1a Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia. (Masters Thesis). University of Toledo Health Science Campus. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=mco1468407344

Chicago Manual of Style (16^th Edition):

Alzhrani, Rami Mohammed. “Tanshinone IIA Inhibits VEGF Secretion and HIF-1a Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia.” 2016. Masters Thesis, University of Toledo Health Science Campus. Accessed March 03, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=mco1468407344.

MLA Handbook (7^th Edition):

Alzhrani, Rami Mohammed. “Tanshinone IIA Inhibits VEGF Secretion and HIF-1a Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia.” 2016. Web. 03 Mar 2021.

Vancouver:

Alzhrani RM. Tanshinone IIA Inhibits VEGF Secretion and HIF-1a Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia. [Internet] [Masters thesis]. University of Toledo Health Science Campus; 2016. [cited 2021 Mar 03]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=mco1468407344.

Council of Science Editors:

Alzhrani RM. Tanshinone IIA Inhibits VEGF Secretion and HIF-1a Expression in Cultured Human Retinal Pigment Epithelial Cells under Hypoxia. [Masters Thesis]. University of Toledo Health Science Campus; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=mco1468407344

Brno University of Technology

17. Lukačovič, Martin. Využitie grafických procesorov pre univerzálne výpočty v priemyselných systémoch: General Processing on Graphics Processing Units for Industrial Systems.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/34286

► The thesis deals with the abilities of graphics processors for GPGPU. It contains historical solutions to contemporary design. There are also described graphics processors from… (more)

Subjects/Keywords: GPGPU; GPU; CPU; NVIDIA; Intel; AMD; OpenCL; paralelizácia; GPGPU; GPU; CPU; NVIDIA; AMD; Intel; OpenCL; parallelization

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lukačovič, M. (2019). Využitie grafických procesorov pre univerzálne výpočty v priemyselných systémoch: General Processing on Graphics Processing Units for Industrial Systems. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/34286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lukačovič, Martin. “Využitie grafických procesorov pre univerzálne výpočty v priemyselných systémoch: General Processing on Graphics Processing Units for Industrial Systems.” 2019. Thesis, Brno University of Technology. Accessed March 03, 2021. http://hdl.handle.net/11012/34286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lukačovič, Martin. “Využitie grafických procesorov pre univerzálne výpočty v priemyselných systémoch: General Processing on Graphics Processing Units for Industrial Systems.” 2019. Web. 03 Mar 2021.

Vancouver:

Lukačovič M. Využitie grafických procesorov pre univerzálne výpočty v priemyselných systémoch: General Processing on Graphics Processing Units for Industrial Systems. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11012/34286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lukačovič M. Využitie grafických procesorov pre univerzálne výpočty v priemyselných systémoch: General Processing on Graphics Processing Units for Industrial Systems. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/34286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

18. Šlenker, Samuel. Výpočetní jednotky procesorů poslední generace a jejich využití: Processing units of last generation processors and their utilization.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/41353

► The aim of this thesis was to study and subsequently process the differences between the older instruction sets and newer instruction sets, to specify the… (more)

Subjects/Keywords: SIMD; SSE; AVX; FMA; vektorové spracovanie dát; Intel; AMD; SIMD; SSE; AVX; FMA; vector data processing; Intel; AMD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Šlenker, S. (2019). Výpočetní jednotky procesorů poslední generace a jejich využití: Processing units of last generation processors and their utilization. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/41353

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Šlenker, Samuel. “Výpočetní jednotky procesorů poslední generace a jejich využití: Processing units of last generation processors and their utilization.” 2019. Thesis, Brno University of Technology. Accessed March 03, 2021. http://hdl.handle.net/11012/41353.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Šlenker, Samuel. “Výpočetní jednotky procesorů poslední generace a jejich využití: Processing units of last generation processors and their utilization.” 2019. Web. 03 Mar 2021.

Vancouver:

Šlenker S. Výpočetní jednotky procesorů poslední generace a jejich využití: Processing units of last generation processors and their utilization. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11012/41353.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Šlenker S. Výpočetní jednotky procesorů poslední generace a jejich využití: Processing units of last generation processors and their utilization. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/41353

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

19. Lin, Keng-Min. Refilling mechanism to stabilize a free-floating intraocular capsule drug ring.

Degree: MS, Mechanical Engineering, 2011, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/576/rec/2050

► This work discusses several ways to grab and refill an intraocular drug device targeting age-related macular degeneration (AMD). The capsule drug ring (CDR) is an… (more)

Subjects/Keywords: AMD; CDR; Implant; Intraocular drug delivery; Macular degeneration; Refill

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, K. (2011). Refilling mechanism to stabilize a free-floating intraocular capsule drug ring. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/576/rec/2050

Chicago Manual of Style (16^th Edition):

Lin, Keng-Min. “Refilling mechanism to stabilize a free-floating intraocular capsule drug ring.” 2011. Masters Thesis, University of Utah. Accessed March 03, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/576/rec/2050.

MLA Handbook (7^th Edition):

Lin, Keng-Min. “Refilling mechanism to stabilize a free-floating intraocular capsule drug ring.” 2011. Web. 03 Mar 2021.

Vancouver:

Lin K. Refilling mechanism to stabilize a free-floating intraocular capsule drug ring. [Internet] [Masters thesis]. University of Utah; 2011. [cited 2021 Mar 03]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/576/rec/2050.

Council of Science Editors:

Lin K. Refilling mechanism to stabilize a free-floating intraocular capsule drug ring. [Masters Thesis]. University of Utah; 2011. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/576/rec/2050

20. Neves, Mónica Sofia Furtado Martins. Bio-removal of toxic metals by metal resistant anaerobic bacteria: molecular characterization and performance studies.

Degree: 2010, RCAAP

URL: https://www.rcaap.pt/detail.jsp?id=oai:sapientia.ualg.pt:10400.1/1531

►

Tese de dout., Ciências Biotecnológicas (Biotecnologia Ambiental), Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2010

The objective of the research described in this thesis… (more)

▼

Tese de dout., Ciências Biotecnológicas (Biotecnologia Ambiental), Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2010

The objective of the research described in this thesis was the identification and characterization of anaerobic bacterial communities with high metal resistance and ability for metal removal, thus with potential for application in bioremediation processes. A sulphate-reducing bacteria (SRB) consortium resistant to high concentrations of heavy metals (Fe, Cu, Zn), similar to those typically present in acid mine drainage (AMD), was obtained from a wastewater treatment plant. Moreover, this consortium showed ability to use wine wastes as carbon and electron source. The phylogenetic analysis of the dsr gene sequence revealed that this consortium contains species of SRB affiliated to Desulfovibrio fructosovorans, Desulfovibrio aminophilus and Desulfovibrio desulfuricans. Wine wastes as carbon source for SRB activity were applied with success in a bioremediation process for the treatment of artificial AMD. TGGE fingerprinting and phylogenetic analysis showed that the composition of the community in the bioreactor fed with wine wastes remained stable during the whole time of operation and its bacterial diversity was higher than the community in the bioreactor fed with ethanol. Several microbial communities were investigated for their ability to remove uranium (VI) and additionally the impact of U(VI) on SRB communities was explored. Although the original communities were mainly composed by SRB, after uranium exposure these bacteria were not detected in the communities. The highest efficiency for U(VI) removal was observed with a consortium from a soil collected in Monchique thermal place. Moreover this community also showed ability to remove Cr(VI). However when U(VI) was replaced by Cr(VI) several differences in the structure of the bacterial community were observed. The mechanism of U(VI) removal by this consortium was also investigated and was found that U(VI) removal occurred by enzymatic reduction and bioaccumulation. Phylogenetic analysis of 16S rRNA showed that this community was mainly composed by bacteria closely related to Sporotalea genus and Rhodocyclaceae family.

Fundação para a Ciência e a Tecnologia(FCT)

Advisors/Committee Members: Costa, Maria Clara, Barros, Raúl José Jorge de.

Subjects/Keywords: Bacterial communities; Bioremediation; AMD; Uranium (VI); Chromium (VI)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Neves, M. S. F. M. (2010). Bio-removal of toxic metals by metal resistant anaerobic bacteria: molecular characterization and performance studies. (Thesis). RCAAP. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:sapientia.ualg.pt:10400.1/1531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Neves, Mónica Sofia Furtado Martins. “Bio-removal of toxic metals by metal resistant anaerobic bacteria: molecular characterization and performance studies.” 2010. Thesis, RCAAP. Accessed March 03, 2021. https://www.rcaap.pt/detail.jsp?id=oai:sapientia.ualg.pt:10400.1/1531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Neves, Mónica Sofia Furtado Martins. “Bio-removal of toxic metals by metal resistant anaerobic bacteria: molecular characterization and performance studies.” 2010. Web. 03 Mar 2021.

Vancouver:

Neves MSFM. Bio-removal of toxic metals by metal resistant anaerobic bacteria: molecular characterization and performance studies. [Internet] [Thesis]. RCAAP; 2010. [cited 2021 Mar 03]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:sapientia.ualg.pt:10400.1/1531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Neves MSFM. Bio-removal of toxic metals by metal resistant anaerobic bacteria: molecular characterization and performance studies. [Thesis]. RCAAP; 2010. Available from: https://www.rcaap.pt/detail.jsp?id=oai:sapientia.ualg.pt:10400.1/1531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kyoto University / 京都大学

21. Akagi, Yumiko. MMP20 and ARMS2/HTRA1 are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration : MMP20とARMS2/HTRA1は滲出型加齢黄斑変性の病変サイズと相関する.

Degree: 博士(医学), 2016, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/204581 ; http://dx.doi.org/10.14989/doctor.k19404

新制・課程博士

甲第19404号

医博第4055号

Subjects/Keywords: AMD; GWAS; lesion size; MMP20

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Akagi, Y. (2016). MMP20 and ARMS2/HTRA1 are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration : MMP20とARMS2/HTRA1は滲出型加齢黄斑変性の病変サイズと相関する. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/204581 ; http://dx.doi.org/10.14989/doctor.k19404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Akagi, Yumiko. “MMP20 and ARMS2/HTRA1 are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration : MMP20とARMS2/HTRA1は滲出型加齢黄斑変性の病変サイズと相関する.” 2016. Thesis, Kyoto University / 京都大学. Accessed March 03, 2021. http://hdl.handle.net/2433/204581 ; http://dx.doi.org/10.14989/doctor.k19404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Akagi, Yumiko. “MMP20 and ARMS2/HTRA1 are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration : MMP20とARMS2/HTRA1は滲出型加齢黄斑変性の病変サイズと相関する.” 2016. Web. 03 Mar 2021.

Vancouver:

Akagi Y. MMP20 and ARMS2/HTRA1 are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration : MMP20とARMS2/HTRA1は滲出型加齢黄斑変性の病変サイズと相関する. [Internet] [Thesis]. Kyoto University / 京都大学; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2433/204581 ; http://dx.doi.org/10.14989/doctor.k19404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Akagi Y. MMP20 and ARMS2/HTRA1 are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration : MMP20とARMS2/HTRA1は滲出型加齢黄斑変性の病変サイズと相関する. [Thesis]. Kyoto University / 京都大学; 2016. Available from: http://hdl.handle.net/2433/204581 ; http://dx.doi.org/10.14989/doctor.k19404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

22. Hoffman, Joshua David. Modeling Macular Degeneration Using Quantitative Phenotypes.

Degree: PhD, Human Genetics, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/10680

► Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the United States (US). Although a multitude of studies have… (more)

Subjects/Keywords: AMD; genetics; Age-Related Macular Degeneration; genomics; assocation analysis; linkage analysis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hoffman, J. D. (2015). Modeling Macular Degeneration Using Quantitative Phenotypes. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10680

Chicago Manual of Style (16^th Edition):

Hoffman, Joshua David. “Modeling Macular Degeneration Using Quantitative Phenotypes.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed March 03, 2021. http://hdl.handle.net/1803/10680.

MLA Handbook (7^th Edition):

Hoffman, Joshua David. “Modeling Macular Degeneration Using Quantitative Phenotypes.” 2015. Web. 03 Mar 2021.

Vancouver:

Hoffman JD. Modeling Macular Degeneration Using Quantitative Phenotypes. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1803/10680.

Council of Science Editors:

Hoffman JD. Modeling Macular Degeneration Using Quantitative Phenotypes. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/10680

Penn State University

23. Grettenberger, Christen Lynn. Microbial Communities In Acid Mine Drainage Ecosystems.

Degree: 2015, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/27394

► Microbial communities are important ecosystem engineers and they profoundly affect local and global biogeochemical cycling. For this reason, they can play important roles in bioremediation… (more)

▼ Microbial communities are important ecosystem engineers and they profoundly affect local and global biogeochemical cycling. For this reason, they can play important roles in bioremediation – we can harness their metabolic power to efficiently and inexpensively remediate environmental problems like acid mine drainage (AMD). Acid mine drainage is an industry-related pollution problem affecting watersheds globally. Current remediation strategies are often costly and ineffective. However, there has been recent interest in using bioremediation to treat AMD. This idea is based on the premise that naturally occurring iron(II)-oxidizing species can remove iron and other metals from AMD. To do so, it is necessary to understand microbial ecology in these ecosystems. This research aimed to discover the microbial factors that control the rate of iron-oxidation at a number of AMD sites and identify the ways in which these microbes alter biogeochemical cycling and may serve as valuable model systems in microbial ecology and bioremediation. Specifically, I aimed to (1) to identify the microbial species responsible for high iron-oxidation rates at Scalp Level Run, an AMD site where iron is removed five to seven times faster than other sites in PA and the Iberian Pyrite Belt, (2) to determine how microbial community composition and metabolic potential in subsurface microbial communities is influenced by subsurface geochemical gradients, and (3) to determine if geography may play a role in structuring microbial populations in AMD ecosystems. The microbial communities at Scalp Level contain a taxon closely related to Ferritrophicum radicicola, which is not found at other AMD sites. The presence of this taxa distinguishes Scalp Level from other sites, but the role it plays in biogeochemical cycling is unknown. At Brubaker Run, I found that, although community composition is different in surface than in subsurface microbial communities, their metabolic potential is not significantly different in the surface than the subsurface. Lastly, microbial communities in AMD may adhere to the distance-decay relationship. There is dispersal limitation between distant sites. This may indicate that for bioremediation to be successful, microbes may need to be transplanted from one site to another. Advisors/Committee Members: Jennifer Macalady, Dissertation Advisor/Co-Advisor, Erica A H Smithwick, Committee Chair/Co-Chair, William D Burgos, Committee Member, Christopher Howard House, Committee Member.

Subjects/Keywords: microbial ecology; ecology; acid mine drainage; AMD; metagenomics; next-generation sequencing

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grettenberger, C. L. (2015). Microbial Communities In Acid Mine Drainage Ecosystems. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/27394

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grettenberger, Christen Lynn. “Microbial Communities In Acid Mine Drainage Ecosystems.” 2015. Thesis, Penn State University. Accessed March 03, 2021. https://submit-etda.libraries.psu.edu/catalog/27394.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grettenberger, Christen Lynn. “Microbial Communities In Acid Mine Drainage Ecosystems.” 2015. Web. 03 Mar 2021.

Vancouver:

Grettenberger CL. Microbial Communities In Acid Mine Drainage Ecosystems. [Internet] [Thesis]. Penn State University; 2015. [cited 2021 Mar 03]. Available from: https://submit-etda.libraries.psu.edu/catalog/27394.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grettenberger CL. Microbial Communities In Acid Mine Drainage Ecosystems. [Thesis]. Penn State University; 2015. Available from: https://submit-etda.libraries.psu.edu/catalog/27394

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Miami

24. Ayala-Haedo, Juan A. Understanding the Role of Novel Gene-Environmental and Gene-Gene Interactions in the Pathogenesis of Age Related Macular Degeneration.

Degree: PhD, Molecular Cell and Developmental Biology (Medicine), 2010, University of Miami

URL: https://scholarlyrepository.miami.edu/oa_dissertations/944

► The purpose of the study was to assess single nucleotide polymorphisms (SNPs) in NOS2 A, ESR1, ESR2 and MMP-2 genes that may affect the… (more)

▼ The purpose of the study was to assess single nucleotide polymorphisms (SNPs) in NOS2 A, ESR1, ESR2 and MMP-2 genes that may affect the risk for age-related macular degeneration (AMD) and may interact with environmental factors such as estrogen exposure and smoking, thereby modifying their effect on AMD. AMD is an ocular degenerative disease with known genetic and environmental factors. However, the disease risk genes identified so far account only for part of the genetic attributable risk and the role of new disease risk genes remain to be evaluated. For non-genetic risk factors, the most extensively analyzed are smoking and estrogen exposure. Smoking increases the risk for development of AMD and estrogen exposure has a protective effect. Both of these factors have been linked to oxidative pathway activation and extracellular matrix homeostasis (ECM) through interactions with the NOS2A and metallomatrix proteinase (MMP) genes, respectively. In addition, estrogen exerts its activity through the estrogen receptors ER alpha and ER beta. We examined a Caucasian cohort of AMD cases and controls. Nine hundred and ninety-eight individuals (males and females) for the NOS2A gene and 777 females for both the ESR1/2 and MMP-2 genes were assessed. We genotyped TagSNPs within these selected candidate gene regions using HapMap phase II or III. Multivariable logistic regression or generalized estimating equation (GEE) models containing SNP genotypes, age, sex, environmental factor and genotype/environmental interaction were constructed. In addition, because we previously reported interactions between the ARMS2 locus and estrogen exposure and smoking, we also analyzed interactions within ARMS2 locus. We found that SNPs in NOS2A are associated with increased risk for AMD and might modulate the smoking effect on AMD. The synergistic interaction between NOS2A and smoking is independent of the ARMS2 locus. No SNP in the MMP-2 gene was significantly associated with increased risk for AMD. We also detected no significant interactions with estrogen exposure or with the ARMS2 locus. SNPs within the ESR1 gene are associated with an increased risk for developing AMD and the inverse association of AMD and HRT is dependent on SNP genotypes in ESR1 and ESR2 and independent of the ARMS2 locus. Advisors/Committee Members: Vinata B. Lokeshwar, Richard K. Lee, John R. Gilbert, Margaret A. Pericak-Vance.

Subjects/Keywords: Gene-gene And Gene-environmental Interactions; Genetics; AMD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ayala-Haedo, J. A. (2010). Understanding the Role of Novel Gene-Environmental and Gene-Gene Interactions in the Pathogenesis of Age Related Macular Degeneration. (Doctoral Dissertation). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_dissertations/944

Chicago Manual of Style (16^th Edition):

Ayala-Haedo, Juan A. “Understanding the Role of Novel Gene-Environmental and Gene-Gene Interactions in the Pathogenesis of Age Related Macular Degeneration.” 2010. Doctoral Dissertation, University of Miami. Accessed March 03, 2021. https://scholarlyrepository.miami.edu/oa_dissertations/944.

MLA Handbook (7^th Edition):

Ayala-Haedo, Juan A. “Understanding the Role of Novel Gene-Environmental and Gene-Gene Interactions in the Pathogenesis of Age Related Macular Degeneration.” 2010. Web. 03 Mar 2021.

Vancouver:

Ayala-Haedo JA. Understanding the Role of Novel Gene-Environmental and Gene-Gene Interactions in the Pathogenesis of Age Related Macular Degeneration. [Internet] [Doctoral dissertation]. University of Miami; 2010. [cited 2021 Mar 03]. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/944.

Council of Science Editors:

Ayala-Haedo JA. Understanding the Role of Novel Gene-Environmental and Gene-Gene Interactions in the Pathogenesis of Age Related Macular Degeneration. [Doctoral Dissertation]. University of Miami; 2010. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/944

University of South Florida

25. Fnu, Gulimirerouzi. Pazopanib Loaded PLGA Nanoparticles for the Treatment of Age-related Macular Degeneration.

Degree: 2019, University of South Florida

URL: https://scholarcommons.usf.edu/etd/8360

► Age-related macular degeneration (AMD) is a reason of severe vision loss worldwide. Pazopanib is a multitargeted tyrosine kinase inhibitor drug that can reduce neovascularization by… (more)

Subjects/Keywords: AMD; Pazopanib; PLGA nanoparticles; sustained release; Medicinal Chemistry and Pharmaceutics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fnu, G. (2019). Pazopanib Loaded PLGA Nanoparticles for the Treatment of Age-related Macular Degeneration. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/8360

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fnu, Gulimirerouzi. “Pazopanib Loaded PLGA Nanoparticles for the Treatment of Age-related Macular Degeneration.” 2019. Thesis, University of South Florida. Accessed March 03, 2021. https://scholarcommons.usf.edu/etd/8360.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fnu, Gulimirerouzi. “Pazopanib Loaded PLGA Nanoparticles for the Treatment of Age-related Macular Degeneration.” 2019. Web. 03 Mar 2021.

Vancouver:

Fnu G. Pazopanib Loaded PLGA Nanoparticles for the Treatment of Age-related Macular Degeneration. [Internet] [Thesis]. University of South Florida; 2019. [cited 2021 Mar 03]. Available from: https://scholarcommons.usf.edu/etd/8360.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fnu G. Pazopanib Loaded PLGA Nanoparticles for the Treatment of Age-related Macular Degeneration. [Thesis]. University of South Florida; 2019. Available from: https://scholarcommons.usf.edu/etd/8360

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Forest, David. Development of Cell Culture Models for Age-related Macular Degeneration.

Degree: 2015, University of California – eScholarship, University of California

URL: http://www.escholarship.org/uc/item/8804x2zv

► Age-related macular degeneration (AMD) is a blinding disorder which affects millions of elderly people worldwide. AMD etiology is still not completely understood, and treatments for… (more)

Subjects/Keywords: Cellular biology; AMD; Cell-culture; Degeneration; Drusen; Macular; Model

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Forest, D. (2015). Development of Cell Culture Models for Age-related Macular Degeneration. (Thesis). University of California – eScholarship, University of California. Retrieved from http://www.escholarship.org/uc/item/8804x2zv

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Forest, David. “Development of Cell Culture Models for Age-related Macular Degeneration.” 2015. Thesis, University of California – eScholarship, University of California. Accessed March 03, 2021. http://www.escholarship.org/uc/item/8804x2zv.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Forest, David. “Development of Cell Culture Models for Age-related Macular Degeneration.” 2015. Web. 03 Mar 2021.

Vancouver:

Forest D. Development of Cell Culture Models for Age-related Macular Degeneration. [Internet] [Thesis]. University of California – eScholarship, University of California; 2015. [cited 2021 Mar 03]. Available from: http://www.escholarship.org/uc/item/8804x2zv.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Forest D. Development of Cell Culture Models for Age-related Macular Degeneration. [Thesis]. University of California – eScholarship, University of California; 2015. Available from: http://www.escholarship.org/uc/item/8804x2zv

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

27. Hutton-Smith, Laurence. Modelling the pharmacokinetics and pharmacodynamics of macromolecules for the treatment of wet AMD.

Degree: PhD, 2018, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:5c6d908f-ebf1-4006-8666-862a17c3f799 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.757871

► Wet age related macular degeneration (wet AMD) is a highly debilitating retinal disease, the third leading cause of blindness in the world and one the… (more)

▼ Wet age related macular degeneration (wet AMD) is a highly debilitating retinal disease, the third leading cause of blindness in the world and one the most expensive ocular conditions to care for. Wet AMD is characterised by the proliferation of neovasculature through the retinal posterior and theorised to be, at least in part, induced and driven by excess vascular endothelial growth factor (VEGF). Many current treatments for wet AMD utilise anti-VEGF macromolecules that bind to VEGF. The retina, however, remains a largely inaccessible, and delicate, anatomical region. Due to difficulties in collecting clinical and experimental data, mathematical modelling is playing an increasingly prominent role in understanding the distribution (Pharmacokinetics, PK) and drug-to-target interactions (Pharmacodynamics, PD) for treatments of wet AMD. This thesis will focus on ordinary/partial differential equation (ODE/PDE) models for the PK/PD of anti-VEGF therapeutics, administered via intravitreal (IVT) injection into the mammalian eye. We start in Chapter 2 with a 2-compartment PK/PD ODE model of drug-VEGF interactions in the eye, analysing a clinical dataset to estimate key binding parameters between VEGF and the typical anti-VEGF molecule, ranibizumab. In Chapter 3, we extend the PK ODE framework of the 2-compartment model to include a mechanistic description of the retina, to estimate retinal permeability to macromolecules used for treating wet AMD. In Chapter 4, using the retinal PK model, we reintroduce VEGF to predict concentrations of free VEGF in the retina post-IVT injection. Chapters 5 and 6 model a hypothetical class of anti-VEGF molecules designed to bind not only VEGF but also existing vitreal superstructures, analysing how dose and binding kinetics impact ocular retention. Alongside these models we present analogous PDE models, addressing whether the assumption that concentrations are homogeneous across anatomical regions, as implicit in ODE models, is appropriate for macromolecular PK/PD in the mammalian eye.

Subjects/Keywords: 510; PK/PD; wet amd; IVT injection; mathematical modelling

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hutton-Smith, L. (2018). Modelling the pharmacokinetics and pharmacodynamics of macromolecules for the treatment of wet AMD. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:5c6d908f-ebf1-4006-8666-862a17c3f799 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.757871

Chicago Manual of Style (16^th Edition):

Hutton-Smith, Laurence. “Modelling the pharmacokinetics and pharmacodynamics of macromolecules for the treatment of wet AMD.” 2018. Doctoral Dissertation, University of Oxford. Accessed March 03, 2021. http://ora.ox.ac.uk/objects/uuid:5c6d908f-ebf1-4006-8666-862a17c3f799 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.757871.

MLA Handbook (7^th Edition):

Hutton-Smith, Laurence. “Modelling the pharmacokinetics and pharmacodynamics of macromolecules for the treatment of wet AMD.” 2018. Web. 03 Mar 2021.

Vancouver:

Hutton-Smith L. Modelling the pharmacokinetics and pharmacodynamics of macromolecules for the treatment of wet AMD. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2021 Mar 03]. Available from: http://ora.ox.ac.uk/objects/uuid:5c6d908f-ebf1-4006-8666-862a17c3f799 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.757871.

Council of Science Editors:

Hutton-Smith L. Modelling the pharmacokinetics and pharmacodynamics of macromolecules for the treatment of wet AMD. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:5c6d908f-ebf1-4006-8666-862a17c3f799 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.757871

University of Melbourne

28. Riaz, Moeen. Investigating the pharmacogenetic basis of Age-related Macular Degeneration (AMD) with anti-VEGF treatments.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/213968

► Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss and blindness in elderly people in the developed world. The two main… (more)

▼ Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss and blindness in elderly people in the developed world. The two main vision threating subtypes are geographic atrophy (GA) and neovascular AMD (nAMD). The latter is responsible for 90% of vision loss attributed to the disease. Currently, the treatment for nAMD is through the use of intravitreal injections of anti-Vascular endothelial growth factor (anti-VEGF) agents. Randomized controlled clinical trials and retrospective studies conducted for anti-VEGF treatment in nAMD patients have shown good improvements in visual outcomes in the majority of patients but due to unknown reasons, a broad range of outcome responses have also been reported. Approximately 5-10% of patients typically show no improvement in the readout of visual acuity (VA) (loss of > 15 Early Treatment Diabetic Retinopathy Study (ETDRS) letters) and exhibit a continuous decline in VA over the course of long term anti-VEGF therapy. A number of studies have indicated factors that might influence the response to treatment, which includes demographic, clinical and genetics factors. Among these, genetic factors are considered as one important determinant which likely result in a pharmacogenetic anti-VEGF treatment response. Genetic factors have been investigated for their association with change in VA following anti-VEGF treatment but these have been based on VEGF pathway genes as well as known AMD risk genes including CFH, ARMS2/HTRA1, VEGFR2, EPAS1 and APOE. Currently, findings from these genetic studies appear inconsistent with regard to their associations with anti-VEGF treatment outcomes (detailed in Chapter 2). This indicates that it is possible that other genetic factors are involved in determining response to anti-VEGF treatment in nAMD patients. Identifying these potential genetic variants across the human genome requires the use of sophisticated genetic techniques such as genome wide association studies (GWAS) and whole exome sequencing (WES). The objective of my PhD is to undertake pharmacogenetic studies to identify genetic variants which could influence anti-VEGF treatment outcome in nAMD patients. To accomplish this, I have used strategies which include candidate gene analysis and the next generation genetic techniques: GWAS and WES. Firstly, in Chapter 4, I assessed the genetic association of several previously described single nucleotide polymorphisms (SNPs) rs4576072 (VEGFR2), rs6828477 (VEGFR2), rs2070296 (NRP1) and rs9679290 (EPAS1) with regard to treatment outcome in nAMD after anti-VEGF treatment. A total of 207 nAMD patients were genotyped for these 4 SNPs with readout outcome measures of change in visual acuity (VA), retinal fluid clearance and central macular thickness (CMT) as measured by optical coherence tomography (OCT) following up-to 1 year of anti-VEGF treatment. Statistical analysis revealed no significant association between the genotypes of these four variants with change in VA at 3, 6 and 12 months of anti-VEGF…

Subjects/Keywords: pharmacogenetics; neovascular AMD; GWAS; exome sequencing; rare variants; anti-VEGF treatment

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Riaz, M. (2017). Investigating the pharmacogenetic basis of Age-related Macular Degeneration (AMD) with anti-VEGF treatments. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/213968

Chicago Manual of Style (16^th Edition):

Riaz, Moeen. “Investigating the pharmacogenetic basis of Age-related Macular Degeneration (AMD) with anti-VEGF treatments.” 2017. Doctoral Dissertation, University of Melbourne. Accessed March 03, 2021. http://hdl.handle.net/11343/213968.

MLA Handbook (7^th Edition):

Riaz, Moeen. “Investigating the pharmacogenetic basis of Age-related Macular Degeneration (AMD) with anti-VEGF treatments.” 2017. Web. 03 Mar 2021.

Vancouver:

Riaz M. Investigating the pharmacogenetic basis of Age-related Macular Degeneration (AMD) with anti-VEGF treatments. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11343/213968.

Council of Science Editors:

Riaz M. Investigating the pharmacogenetic basis of Age-related Macular Degeneration (AMD) with anti-VEGF treatments. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/213968

29. Romano, Giovanni Luca. miRNA expressione profiles in retinal neurodegenerative diseases.

Degree: 2017, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/4028

► MicroRNAs (miRNAs) are non-coding small RNAs, which have been found to regulate gene expression at the post-transcriptional and translational levels. A lot of studies demonstrated… (more)

▼ MicroRNAs (miRNAs) are non-coding small RNAs, which have been found to regulate gene expression at the post-transcriptional and translational levels. A lot of studies demonstrated that miRNAs regulate various cellular processes, including differentiation, development, aging, apoptosis, oncogenesis and metabolism. Moreover, dysregulation of specific miRNAs is associated with a variety of diseases, including neurodegenerative disorders. Identification of differenzial pattern expression of miRNAs could be of value for development of novel biomarkers and discovery of new pharmacological targets for human diseases. The aim of our research was to investigate miRNAs regulation in neurodegenerative diseases. Glaucoma is a progressive optic nerve neuropathy and it is one of the leading cause of blindness in the industrialized countries. Age related macular degeneration (AMD) is the leading cause of blindness among people aged 50 and over. Signs of irreversible neurodegeneration in glaucoma, AMD and Alzheimer s disease (AD), are usually evident at least a decade after onset of disease; thus early diagnosis is an urgent need in order to start effective therapy against neurodegenerative process. Identification of deregulated miRNA and associated pathways common to glaucoma, AMD and AD might help in the challenging search of biomarkers and novel therapeutic strategies. We found, from literature search, 8 deregulated miRNAs in glaucoma, 9 and 23 in AMD and AD, respectively. One miRNA was found to be commonly deregulated in glaucoma and AMD (miR-23a), two miRNA (miR-29a, miR-29b) in glaucoma and AD, and four miRNAs in AMD and AD (miR-9, miR-31, miR-21, miR-34a, miR-146a). Predicted miRNAs common to the three neurodegenerative diseases were 9 (miR-107, miR-137, miR-146a, miR-181c, miR-197, miR-21, miR-22, miR-590, miR-9), which demonstrate to be involved in the regulation of inflammation pathways. Based on prediction of miRNA and associated biochemical pathways, inflammation could represent a therapeutic target common to glaucoma, AMD and AD. Then we evaluated the differential expression profile of miRNAs in a rat model of AMD and in patients with AMD. Analysis of rat retina revealed that miR-27a, miR-146a and miR-155 are up-regulated in comparison to control rats. Seven miRNA (miR-9, miR-23a, miR-27a, miR-34a, miR-126, miR-146a and miR-155) have been found to be dysregulated in serum of AMD patients in comparison to control group. Dysregulated miRNAs, both in the AMD animal model and in AMD patients, can target genes regulating pathways linked to neurodegeneration and inflammation. Our findings support the assessment of specific miRNAs as potential biomarkers and therapeutic targets in retinal neurodegenerative diseases by means of preclinical and clinical studies.

Subjects/Keywords: Area 06 - Scienze mediche; MicroRNA, Glaucoma, AMD, Neurodegeneration, Biomarkers

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Romano, G. L. (2017). miRNA expressione profiles in retinal neurodegenerative diseases. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/4028

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Romano, Giovanni Luca. “miRNA expressione profiles in retinal neurodegenerative diseases.” 2017. Thesis, Università degli Studi di Catania. Accessed March 03, 2021. http://hdl.handle.net/10761/4028.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Romano, Giovanni Luca. “miRNA expressione profiles in retinal neurodegenerative diseases.” 2017. Web. 03 Mar 2021.

Vancouver:

Romano GL. miRNA expressione profiles in retinal neurodegenerative diseases. [Internet] [Thesis]. Università degli Studi di Catania; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10761/4028.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Romano GL. miRNA expressione profiles in retinal neurodegenerative diseases. [Thesis]. Università degli Studi di Catania; 2017. Available from: http://hdl.handle.net/10761/4028

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Despriet, Dominique. Genetics of Age-Related Macular Degeneration: new insights and perspectives.

Degree: Department of Ophthalmology, 2008, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/11512

► textabstractApproximately 30.5 million people aged 50 years and older are blind worldwide.1 Visual impairment, or low vision that cannot be corrected with glasses, leads to… (more)

Subjects/Keywords: AMD; blindness; genetics; macular degeneration

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Despriet, D. (2008). Genetics of Age-Related Macular Degeneration: new insights and perspectives. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/11512

Chicago Manual of Style (16^th Edition):

Despriet, Dominique. “Genetics of Age-Related Macular Degeneration: new insights and perspectives.” 2008. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 03, 2021. http://hdl.handle.net/1765/11512.

MLA Handbook (7^th Edition):

Despriet, Dominique. “Genetics of Age-Related Macular Degeneration: new insights and perspectives.” 2008. Web. 03 Mar 2021.

Vancouver:

Despriet D. Genetics of Age-Related Macular Degeneration: new insights and perspectives. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2008. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1765/11512.

Council of Science Editors:

Despriet D. Genetics of Age-Related Macular Degeneration: new insights and perspectives. [Doctoral Dissertation]. Erasmus University Medical Center; 2008. Available from: http://hdl.handle.net/1765/11512

Open Access Theses and Dissertations