subject:(AIF)

University of Manitoba

1. Weng, Jiequn. Protect neurons from ischemia-induced death by targeting BNIP3 gene family.

Degree: Human Anatomy and Cell Science, 2012, University of Manitoba

URL: http://hdl.handle.net/1993/8109

► The BNIP3 family, a group of death-inducing mitochondrial proteins, includes BNIP3, NIX and BNIP3h. These proteins share structural and functional similarities. BNIP3 causes neuronal cell… (more)

▼ The BNIP3 family, a group of death-inducing mitochondrial proteins, includes BNIP3, NIX and BNIP3h. These proteins share structural and functional similarities. BNIP3 causes neuronal cell death in a necrosis-like, caspase-independent manner with mitochondrial dysfunction. We reported that BNIP3 plays a role in delayed neuronal death in stroke models. Over-expression of BNIP3 causes up to 70% neuronal death, while knockdown of BNIP3 only protects 23% neurons from hypoxia. Thus, we hypothesize that other members of the BNIP3 subfamily compensate for the loss of BNIP3. BNIP3 and NIX were highly upregulated in the oxygen and glucose deprivation (OGD)/reoxygenation model, and knockdown of BNIP3 or NIX protected about 20% - 44% of neurons. Knockdown of BNIP3 family reduced neuronal death by 48%. Mitochondrial membrane potential loss, mitochondrial permeability transition pore (MPTP) opening and reactive oxygen species (ROS) production were all significantly attenuated by BNIP3 and/or NIX inhibition. AIF and EndoG were reported involving in caspase-independent cell death in ischemic stroke. We found that AIF was released from mitochondria and translocated into nuclei in neurons after OGD/reoxygenation, while inhibition of BNIP3 blocked AIF and EndoG translocation and prevented neuronal death. Over-expression of BNIP3 and NIX caused AIF translocation and subsequent neuronal death. These data reveal the effects of the BNIP3 family in neuronal death and indicate that AIF and EndoG are two downstream factors in the BNIP3-mediated cell death pathway. Meanwhile, necrostatin-1 (Nec-1), an inhibitor for a caspase-independent necrotic cell death, is able to protect neurons from death in stroke, mechanism of which is unclear. Here, we confirmed that Nec-1 significantly increased survival of neurons in models of stroke in vivo and in vitro. It also attenuated hypoxia or BNIP3-induced mitochondrial dysfunction and prevented mitochondrial release of AIF. Nec-1 did not affect the expression levels of BNIP3 but prevented its integration into mitochondria. These results suggest that Nec-1 protects neurons against ischemia by targeting BNIP3. In summary, this research indicates that the BNIP3 family is one of the regulators of caspase-independent neuronal death in stroke and that Nec-1 is an inhibitor for BNIP3 and a potential therapeutic agent for stroke. Advisors/Committee Members: Kong, Jiming (Human Anatomy and Cell Science) (supervisor), Vrontakis-Lautatzis, Maria (Human Anatomy and Cell Science) Anderson, Judith (Biological Science) Parkinson, Fiona (Pharmacology & Therapeutics) Namaka, Mike (Pharmacy) Wang, Yutian (University of British Columbia) (examiningcommittee).

Subjects/Keywords: BNIP3; ischemia; AIF; stroke

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APA (6^th Edition):

Weng, J. (2012). Protect neurons from ischemia-induced death by targeting BNIP3 gene family. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/8109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weng, Jiequn. “Protect neurons from ischemia-induced death by targeting BNIP3 gene family.” 2012. Thesis, University of Manitoba. Accessed January 22, 2021. http://hdl.handle.net/1993/8109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weng, Jiequn. “Protect neurons from ischemia-induced death by targeting BNIP3 gene family.” 2012. Web. 22 Jan 2021.

Vancouver:

Weng J. Protect neurons from ischemia-induced death by targeting BNIP3 gene family. [Internet] [Thesis]. University of Manitoba; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1993/8109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weng J. Protect neurons from ischemia-induced death by targeting BNIP3 gene family. [Thesis]. University of Manitoba; 2012. Available from: http://hdl.handle.net/1993/8109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Sherbrooke

2. Poulin, Éric. Modélisation pharmacocinétique combinée IRM-TEP.

Degree: 2012, Université de Sherbrooke

URL: http://hdl.handle.net/11143/6351

► Au cours des dernières années, des modalités d'imagerie comme la tomographie d'émission par positrons (TEP) et l'imagerie par résonance magnétique (IRM) ont été utilisées pour… (more)

▼ Au cours des dernières années, des modalités d'imagerie comme la tomographie d'émission par positrons (TEP) et l'imagerie par résonance magnétique (IRM) ont été utilisées pour caractériser le microenvironnement tumoral et prédire la réponse au traitement durant la thérapie. La TEP est reconnue pour sa fonctionnalité et elle est utilisée avec une multitude de radiotraceurs. Par contre, sa résolution spatiale est limitée. L'IRM apporte une localisation anatomique précise et une information sur la perfusion des tissus. La modélisation pharmacocinétique augmente le potentiel de ces deux modalités en permettant des études quantitatives. Cependant, ces analyses quantitatives nécessitent l'acquisition de plusieurs images successives afin de suivre la distribution d'un agent de contraste (AC) en IRM et d'un radiotraceur en TEP. Plusieurs types d'analyse pharmacocinétique en IRM et en TEP requièrent la concentration de l'agent en fonction du temps dans le sang, nommée fonction d'entrée artérielle (AIF). Toutefois, cette dernière est difficile à mesurer. En IRM, pour la modélisation, il existe un compromis à faire entre la résolution spatiale et la résolution temporelle. Dans ce mémoire, une approche pour convertir l'AIF d'une modalité à l'autre est proposée pour le petit animal. L'AC gadolinium-acide diéthylène-triamine penta-acétique (Gd-DTPA) en IRM et le radiotraceur [indice supérieur 18] F-fluorodésoxyglucose (FDG) en TEP ont été utilisés. Un modèle mathématique a été développé pour effectuer la conversion et comparer les AIFs. Afin d'évaluer l'efficacité de la méthode, les paramètres pharmacocinétiques ont été calculés pour l'AIF obtenue par prélèvements sanguins et par notre méthode de conversion. Aucune différence statistique n'a été trouvée entre les paramètres des deux méthodes. Ces résultats suggèrent donc qu'une seule AIF serait nécessaire pour faire la modélisation dans les deux modalités. Une méthode qui optimise le temps d'acquisition d'images de même que la résolution spatiale en IRM a été proposée afin d'obtenir une quantification tumorale plus juste. Le temps d'acquisition a été réduit d'un facteur 3,2 avec une perte négligeable (1,5%) de résolution spatiale. Il a également été démontré qu'il est possible d'utiliser la méthode de région de référence combinée avec notre méthode de conversion d'AIF afin de faire la modélisation dans les deux modalités. Il s'agit, à notre connaissance, du premier travail évaluant la synergie entre les acquisitions IRM et TEP combinées. Ce travail pourrait donc avoir un impact significatif sur l'exploitation des deux modalités d'imagerie. Advisors/Committee Members: Lepage, Martin (advisor), Bentourkia, M’Hamed (advisor).

Subjects/Keywords: AIF; Modélisation pharmacocinétique; IRM-TEP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Poulin, �. (2012). Modélisation pharmacocinétique combinée IRM-TEP. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/6351

Chicago Manual of Style (16^th Edition):

Poulin, Éric. “Modélisation pharmacocinétique combinée IRM-TEP.” 2012. Masters Thesis, Université de Sherbrooke. Accessed January 22, 2021. http://hdl.handle.net/11143/6351.

MLA Handbook (7^th Edition):

Poulin, Éric. “Modélisation pharmacocinétique combinée IRM-TEP.” 2012. Web. 22 Jan 2021.

Vancouver:

Poulin �. Modélisation pharmacocinétique combinée IRM-TEP. [Internet] [Masters thesis]. Université de Sherbrooke; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11143/6351.

Council of Science Editors:

Poulin �. Modélisation pharmacocinétique combinée IRM-TEP. [Masters Thesis]. Université de Sherbrooke; 2012. Available from: http://hdl.handle.net/11143/6351

University of New South Wales

3. Brown, Ashleigh. Lions led by donkeys? Brigade commanders of the Australian Imperial Force, 1914-1918.

Degree: Humanities & Social Sciences, 2017, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/59010 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:48271/SOURCE02?view=true

► Australian First World War historiography tends to focus on the ordinary soldier: his background, character and involvement in the war. This is a legacy left… (more)

Subjects/Keywords: AIF; brigade; commanders; lions; donkeys

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APA (6^th Edition):

Brown, A. (2017). Lions led by donkeys? Brigade commanders of the Australian Imperial Force, 1914-1918. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/59010 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:48271/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Brown, Ashleigh. “Lions led by donkeys? Brigade commanders of the Australian Imperial Force, 1914-1918.” 2017. Masters Thesis, University of New South Wales. Accessed January 22, 2021. http://handle.unsw.edu.au/1959.4/59010 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:48271/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Brown, Ashleigh. “Lions led by donkeys? Brigade commanders of the Australian Imperial Force, 1914-1918.” 2017. Web. 22 Jan 2021.

Vancouver:

Brown A. Lions led by donkeys? Brigade commanders of the Australian Imperial Force, 1914-1918. [Internet] [Masters thesis]. University of New South Wales; 2017. [cited 2021 Jan 22]. Available from: http://handle.unsw.edu.au/1959.4/59010 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:48271/SOURCE02?view=true.

Council of Science Editors:

Brown A. Lions led by donkeys? Brigade commanders of the Australian Imperial Force, 1914-1918. [Masters Thesis]. University of New South Wales; 2017. Available from: http://handle.unsw.edu.au/1959.4/59010 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:48271/SOURCE02?view=true

University of Gothenburg / Göteborgs Universitet

4. Rodríguez, Juan. Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury.

Degree: 2020, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/62221

► Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not… (more)

▼ Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a prominent role, not only due to their central function in metabolism, but also because many proteins with apoptosisrelated functions are located in the mitochondrion. Among these proteins, CHCHD4 and apoptosis-inducing factor (AIF) have already been shown to make important contributions to neuronal cell death upon hypoxia-ischemia (HI), but a better understanding of the mechanisms behind these processes is required for the development of improved treatments. By inducing HI in 9-day-old mice, leading to moderate brain injury, we studied these mechanisms from multiple perspectives. First, we determined the effect of chchd4 haploinsufficiency, and we showed that neonatal mice with this genotype experienced less brain damage due to reduced translocation of AIF and Cytochrome c from the mitochondrion. Second, we characterized the role of a newly discovered AIF isoform (AIF2), which is only expressed in the brain and the functions of which are unknown. By using Aif2 knockout mice, we showed that under physiological conditions there is an increase in Aif1 expression (the ubiquitously expressed isoform) due to a compensatory effect of loss of Aif2 expression. As a result, these mice showed a higher degree of brain damage after HI and were more vulnerable to oxidative stress. Third, we used another transgenic mouse in which Aif was overexpressed by knocking in a proviral insertion of Aif, leading to an increased expression of Aif1 without affecting the expression of Aif2. This mouse also showed a higher degree of brain damage and higher levels of oxidative stress. Finally, we used a peptide designed to block the apoptotic function of AIF. The results in young mice showed that the neuroprotective effect of the peptide was greater in male mice than in female mice. In summary, this PhD project has opened new perspectives in the comprehension of the mechanisms by which CHCHD4 and AIF are crucial proteins for brain damage after HI, and it has showed that AIF is a promising therapeutic target for improving outcome after perinatal brain injury.

Subjects/Keywords: AIF; neonatal; mouse; hypoxia-ischemia; AIF/CypA complex; apoptosis; asphyxia; CHCHD4

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APA (6^th Edition):

Rodríguez, J. (2020). Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/62221

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rodríguez, Juan. “Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury.” 2020. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 22, 2021. http://hdl.handle.net/2077/62221.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rodríguez, Juan. “Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury.” 2020. Web. 22 Jan 2021.

Vancouver:

Rodríguez J. Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2020. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2077/62221.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rodríguez J. Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2020. Available from: http://hdl.handle.net/2077/62221

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

5. Pettersson, Niklas. Vad vill vi med idrotten? : En studie om arbetarpressens syn på den nationella och internationella arbetaridrottsrörelsen under mellankrigstiden.

Degree: History, 2018, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374605

► Under mellankrigstiden växte arbetaridrotten i flertalet länder runt om i världen och den nya socialistiska idrotten firades med arbetarolympiader. I Sverige lyckades aldrig arbetaridrotten… (more)

▼ Under mellankrigstiden växte arbetaridrotten i flertalet länder runt om i världen och den nya socialistiska idrotten firades med arbetarolympiader. I Sverige lyckades aldrig arbetaridrotten få sitt stora genombrott och Sverige deltog varken i arbetarolympiader eller hade särskilt stort samarbete med den internationella arbetaridrottsrörelsen. Denna studie har undersökt varför Sveriges samarbete med den internationella arbetaridrottsrörelsen nästintill uteblev och följaktligen varför Sverige aldrig deltog i arbetarolympiaderna. Genom en kvalitativ innehållsanalys av arbetarpressen under mellankrigstiden har denna studie kartlagt huvudanledningarna till varför Sveriges samarbete med den internationella arbetaridrottsrörelsen var förhållandevis liten. Det svenska socialdemokratiska arbetarpartiet ansåg till skillnad från andra socialdemokratiska partier att den vanliga idrotten var bra för arbetare då detta utgjorde ett neutralt forum som tillät umgänge över klassgränserna. Arbetaridrotten hade inte en naturlig plats i det svenska samhället och man ansåg att den bröt mot idrottens allra heligaste, dess politiska neutralitet. Svenska kommunister var därmot av en annan åsikt och ansåg att idrotten inte alls var politiskt neutral utan ett medel som borgerligheten använde för att förblinda och fördumma arbetarklassen. Arbetaridrotten ansågs därför av kommunister som nödvändig för att arbetare ska kunna bedriva idrott. Det var även kommunister som grundade Arbetarnas Idrottsförbund (AIF). Den internationella arbetaridrotten leddes nästan uteslutande av socialdemokrater. Följaktligen ville det kommunistiska AIF inte beblanda sig med dem och man talade i termer som att ledarna för den internanationella arbetaridrotten var "socialfascister". Socialdemokrater hade heller ingen större vilja att engagera sig för den internationella arbetaridrotten då man ansåg att den vanliga idrotten var en tillräckligt god representant för arbetarnas intressen. På Sovjetunionens initiativ inleddes i mitten av 1930-talet det som kom att kallas för folkfrontspolitiken. Detta innebar ett närmande från kommunister till socialdemokrater för att visa en enad socialistisk front mot den växande fascismen. Detta skedde även i Sverige och från den undersökta kommunistiska pressens reportage från arbetarolympiaden i Antwerpen 1937 finner enbart lovord. Delar av den socialdemokratiska pressen som undersökts tycks också ha ändrat inställning till ett eventuellt svenskt deltagande i arbetarolympiaden i samband med 1937-års arbetarolympiad. Detta verkar dock bero på det svenska deltagandet i de olympiska spelen i Berlin år 1936. Dessa olympiska spel hade varit uppenbart politiskt och Nazityskland tilläts demonstrera sin oerhörda propagandamaskin. Därmed var idéen om idrottens politiska neutraliet bruten och det endast genom svenskt deltagade i dess motpart, arbetarolympiaderna, kunde den återupprättas.

Subjects/Keywords: idrott; arbetaridrott; arbetarolympiad; arbetarpress; AIF; History; Historia

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APA (6^th Edition):

Pettersson, N. (2018). Vad vill vi med idrotten? : En studie om arbetarpressens syn på den nationella och internationella arbetaridrottsrörelsen under mellankrigstiden. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pettersson, Niklas. “Vad vill vi med idrotten? : En studie om arbetarpressens syn på den nationella och internationella arbetaridrottsrörelsen under mellankrigstiden.” 2018. Thesis, Uppsala University. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pettersson, Niklas. “Vad vill vi med idrotten? : En studie om arbetarpressens syn på den nationella och internationella arbetaridrottsrörelsen under mellankrigstiden.” 2018. Web. 22 Jan 2021.

Vancouver:

Pettersson N. Vad vill vi med idrotten? : En studie om arbetarpressens syn på den nationella och internationella arbetaridrottsrörelsen under mellankrigstiden. [Internet] [Thesis]. Uppsala University; 2018. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pettersson N. Vad vill vi med idrotten? : En studie om arbetarpressens syn på den nationella och internationella arbetaridrottsrörelsen under mellankrigstiden. [Thesis]. Uppsala University; 2018. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington State University

6. [No author]. INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY .

Degree: 2013, Washington State University

URL: http://hdl.handle.net/2376/4802

► Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the hydrolysis of poly(ADP-ribose) (PAR), which is synthesized by poly(ADP-ribose) polymerases (PARPs) to modify cellular proteins.… (more)

▼ Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the hydrolysis of poly(ADP-ribose) (PAR), which is synthesized by poly(ADP-ribose) polymerases (PARPs) to modify cellular proteins. PARG participates in a number of biological processes, including chromatin dynamics, transcriptional regulation, DNA damage repair, and cell death. However, compared with the established chemotherapeutic potential of inhibiting PAR synthesis by targeting the PARPs, the significance of PARG as a therapeutic target in cancer remains to be elucidated. The first chapter is a literature review of the current knowledge of PARG with a focus on its roles in DNA repair and cell death. In this section, the PAR mediated cell death pathway, Parthanatos, is introduced. Proteins that participate in this pathway including PARP-1, PARG, apoptosis-inducing factor (AIF) and the transient receptor potential, melastatin-2 (TRPM2) Ca2+ channel are discussed. To investigate their roles following DNA damage, we utilized genetic knockout, RNA interference or pharmacological inhibitors to silence PARG and other related proteins. We provide evidence that: 1) the absence of PAR hydrolysis due to the absence of PARG results in the vulnerability of DNA to damaging agents, decreased caspase activity and enhanced AIF mediated cell death; 2) inhibition of both PARP-1 and PARG does not lead to synergistic cell death; 3) silencing of AIF shows the ability of AIF to substitute as a primary mediator of breast cancer cell death in the absence of caspases; and 4) TRPM2 differentially regulates cell proliferation in non-cancerous versus cancerous cells. The inhibition of TRPM2 in breast cancer cells impaired cell growth and greatly enhanced cell death in the presence of chemotherapeutic agents. Thus, by investigating the molecular mechanism of cell death mediated by PAR/PARG, we conclude that the induction of cell death mediated by AIF or specific targeting of TRPM2, has the great potential in chemotherapy to optimize the eradication of breast cancer cells.

Subjects/Keywords: Pharmaceutical sciences; AIF; Cancer; Cell death; Chemotherapy; PAR; PARG

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APA (6^th Edition):

author], [. (2013). INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY . (Thesis). Washington State University. Retrieved from http://hdl.handle.net/2376/4802

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY .” 2013. Thesis, Washington State University. Accessed January 22, 2021. http://hdl.handle.net/2376/4802.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY .” 2013. Web. 22 Jan 2021.

Vancouver:

author] [. INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY . [Internet] [Thesis]. Washington State University; 2013. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2376/4802.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY . [Thesis]. Washington State University; 2013. Available from: http://hdl.handle.net/2376/4802

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

7. Krátká, Lucie. Akvizice MRI obrazových sekvencí pro preklinické perfusní zobrazování: MRI Acquisition of Image Sequences for Preclinical Perfusion Imaging.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/11904

► The task of this thesis is to study methods for the acquisition perfusní imaging based on dynamic MR imaging with T1 contrast. It describes methods… (more)

Subjects/Keywords: DCE MRI; gradientní echo; FLASH; turboFLASH; kontrastní látka; statický a dynamický fantom; AIF; DCE MRI; gradient echo; FLASH; turboFLASH; contrast agent; static and dynamic phantom; AIF

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krátká, L. (2019). Akvizice MRI obrazových sekvencí pro preklinické perfusní zobrazování: MRI Acquisition of Image Sequences for Preclinical Perfusion Imaging. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/11904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krátká, Lucie. “Akvizice MRI obrazových sekvencí pro preklinické perfusní zobrazování: MRI Acquisition of Image Sequences for Preclinical Perfusion Imaging.” 2019. Thesis, Brno University of Technology. Accessed January 22, 2021. http://hdl.handle.net/11012/11904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krátká, Lucie. “Akvizice MRI obrazových sekvencí pro preklinické perfusní zobrazování: MRI Acquisition of Image Sequences for Preclinical Perfusion Imaging.” 2019. Web. 22 Jan 2021.

Vancouver:

Krátká L. Akvizice MRI obrazových sekvencí pro preklinické perfusní zobrazování: MRI Acquisition of Image Sequences for Preclinical Perfusion Imaging. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11012/11904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krátká L. Akvizice MRI obrazových sekvencí pro preklinické perfusní zobrazování: MRI Acquisition of Image Sequences for Preclinical Perfusion Imaging. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/11904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Richard, Marie Anne. Modélisation pharmacocinétique en imagerie par résonance magnétique et en tomographie d’émission par positrons appliquée à un modèle de glioblastome chez le rat.

Degree: 2016, Université de Sherbrooke

URL: http://hdl.handle.net/11143/9709

► Abstract : In medical imaging, different modalities are frequently combined in order to obtain complementary information. For example, positron emission tomography (PET) can be associated… (more)

▼ Abstract : In medical imaging, different modalities are frequently combined in order to obtain complementary information. For example, positron emission tomography (PET) can be associated with magnetic resonance imaging (MRI) to derive both anatomical and biological information. This project explores the synergies between MRI and PET for pharmacokinetic modeling. Specifically, it exploits the high spatial resolution of MRI as well as the information about perfusion and vascular permeability derived from dynamic contrast-enhanced studies to better assess these parameters in a PET radiotracer injected shortly after the MRI examination. This more precise assessment of perfusion is thought to improve metabolism quantification for the radiotracer and to discriminate between its specific and non-specific accumulation. The present work focussed on 2 PET radiotracers, (18F-fluorodeoxyglucose [FDG] and 18F-fluoroethyltyrosine [FET]) as well as a MRI contrast agent (gadopentetic acid [Gd-DTPA]) applied to a rat glioblastoma model. Images were acquired using a sequential MRI-PET protocol and blood was drawn to derive the arterial input function (AIF) for each molecule. PET and MR images were subsequently registered and pharmacokinetic modeling was performed on regions of interest (ROI) or voxel-wise. For FDG, an irreversible 3 compartments (2-tissue) model was used in accordance to the literature. For FET, it was determined that an irreversible 2-tissue model is applicable for the brain and the tumor and a reversible 2-tissue model is preferred for the muscles. AIF (blood or image-derived) conversion between Gd-DTPA and FET, or vice versa, was also considered and proved feasible for the blood AIF derived from the caudal artery, similar to FDG. Finally, combined kinetic modeling for MRI and PET showed a relationship between the perfusion of FDG, or FET, and that of Gd-DTPA in muscle. Important disparities were noted for the tumor. These results illustrate the complexity of the tumor microenvironment (e.g. presence of various transport mechanisms for the same molecule) and the numerous challenges encountered during its characterization in small animals. Advisors/Committee Members: Lepage, Martin (advisor).

Subjects/Keywords: AIF; FDG; FET; Gd-DTPA; IRM; TEP; Modélisation pharmacocinétique; MRI; PET; Kinetic modeling

11 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Richard, M. A. (2016). Modélisation pharmacocinétique en imagerie par résonance magnétique et en tomographie d’émission par positrons appliquée à un modèle de glioblastome chez le rat. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/9709

Chicago Manual of Style (16^th Edition):

Richard, Marie Anne. “Modélisation pharmacocinétique en imagerie par résonance magnétique et en tomographie d’émission par positrons appliquée à un modèle de glioblastome chez le rat.” 2016. Masters Thesis, Université de Sherbrooke. Accessed January 22, 2021. http://hdl.handle.net/11143/9709.

MLA Handbook (7^th Edition):

Richard, Marie Anne. “Modélisation pharmacocinétique en imagerie par résonance magnétique et en tomographie d’émission par positrons appliquée à un modèle de glioblastome chez le rat.” 2016. Web. 22 Jan 2021.

Vancouver:

Richard MA. Modélisation pharmacocinétique en imagerie par résonance magnétique et en tomographie d’émission par positrons appliquée à un modèle de glioblastome chez le rat. [Internet] [Masters thesis]. Université de Sherbrooke; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11143/9709.

Council of Science Editors:

Richard MA. Modélisation pharmacocinétique en imagerie par résonance magnétique et en tomographie d’émission par positrons appliquée à un modèle de glioblastome chez le rat. [Masters Thesis]. Université de Sherbrooke; 2016. Available from: http://hdl.handle.net/11143/9709

9. Cabon, Lauriane. Implication d'AIF dans la mort cellulaire et la physiologie mitochondriale : exemples dans la nécroptose intrinsèque et l'hématopoïèse : Implication of AIF in cell death and mitochondrial physiology : cases of intrinsic necroptosis and hematopoiesis.

Degree: Docteur es, Physiologie physiopathologie, 2014, Université Pierre et Marie Curie – Paris VI

URL: http://www.theses.fr/2014PA066314

►

AIF fait partie des protéines mitochondriales inductrices de mort mais possède aussi un rôle vital nécessaire à la respiration cellulaire. Les recherches menées lors de… (more)

▼

AIF fait partie des protéines mitochondriales inductrices de mort mais possède aussi un rôle vital nécessaire à la respiration cellulaire. Les recherches menées lors de cette thèse portent sur ces deux fonctions. D'une part, j'ai approfondi l'étude de la nécrose régulée induite par un agent alkylant de l'ADN. J'ai découvert l'importance de RIP1 dans cette voie de mort cellulaire et ainsi conduit à la définir comme nécroptose. J'ai aussi mis en évidence le rôle de BID, BH3-only de la famille BCL-2, dans la libération d'AIF des mitochondries. J'ai montré que les protéases calpaïnes clivaient BID permettant à sa forme tronquée de relocaliser aux mitochondries et d'y activer le facteur pro-apoptotique BAX. Cette étude contribue à replacer le rôle des BH3-only dans des voies de mort cellulaire au delà de l'apoptose. D'autre part, j'ai étudié le rôle d'AIF dans l'hématopoïèse grâce à un modèle murin invalidé pour AIF dans ce système. J'ai observé un blocage de différenciation thymique et le développement d'une pancytopénie sévère. J'ai démontré que cette dernière est associée à la perte des cellules souches hématopoïétiques dont j'ai testé les capacités ex vivo et in vivo. Pour comprendre les raisons de ce défaut, j'ai caractérisé les conséquences associées à la perte d'AIF : perte du complexe I de la chaine respiratoire, diminution d'activité de phosphorylation oxydative, diminution de la production d'ATP, augmentation des espèces réactives de l'oxygène. Cette deuxième étude démontre l'importance d'une phosphorylation oxydative fonctionnelle et de mitochondries saines pour une hématopoïèse normale et particulièrement pour le maintien des cellules souches hématopoïétiques.

AIF is one of the cell death effectors released from mitochondria but it also possess a vital role by regulating the cellular respiration. Throughout this thesis work, I have focused my studies on these two functions. On one hand, I have performed a deeper characterization of the DNA alkylating agent induced regulated necrosis. I have identified RIP1 as a crucial determinant of this cell death pathway, hence linking it to necroptosis. I have also highlighted the role of BID, a BH3-only member of the BCL-2 family, in the mitochondrial release of AIF. I have shown that calpains proteases cleave BID into tBID which relocalize to mitochondria where it helps activating the pro-apoptotic factor BAX. This study contributes to reconsider the role of BH3-only proteins in cell death pathways beyond apoptosis. On the other hand, I have studied AIF role in hematopoiesis thanks to a mouse model with hematopoietic lineage-specific deletion of AIF. I have observed a block in T-cell development and the rapid development of severe pancytopenia. I have demonstrated that this pancytopenia is associated with the loss of hematopoietic stem cells whom capacities were tested both ex vivo and in vivo. In order to understand the underlying determinants of these defects, I have characterized the cellular consequences related to AIF deletion : loss of the respiratory chain…

Advisors/Committee Members: Susin, Santos (thesis director).

Subjects/Keywords: AIF; Nécrose régulée; BID; Hématopoïèse; ROS; Métabolisme mitochondrial; Regulated necrosis; Hematopoiesis; 571.6

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cabon, L. (2014). Implication d'AIF dans la mort cellulaire et la physiologie mitochondriale : exemples dans la nécroptose intrinsèque et l'hématopoïèse : Implication of AIF in cell death and mitochondrial physiology : cases of intrinsic necroptosis and hematopoiesis. (Doctoral Dissertation). Université Pierre et Marie Curie – Paris VI. Retrieved from http://www.theses.fr/2014PA066314

Chicago Manual of Style (16^th Edition):

Cabon, Lauriane. “Implication d'AIF dans la mort cellulaire et la physiologie mitochondriale : exemples dans la nécroptose intrinsèque et l'hématopoïèse : Implication of AIF in cell death and mitochondrial physiology : cases of intrinsic necroptosis and hematopoiesis.” 2014. Doctoral Dissertation, Université Pierre et Marie Curie – Paris VI. Accessed January 22, 2021. http://www.theses.fr/2014PA066314.

MLA Handbook (7^th Edition):

Cabon, Lauriane. “Implication d'AIF dans la mort cellulaire et la physiologie mitochondriale : exemples dans la nécroptose intrinsèque et l'hématopoïèse : Implication of AIF in cell death and mitochondrial physiology : cases of intrinsic necroptosis and hematopoiesis.” 2014. Web. 22 Jan 2021.

Vancouver:

Cabon L. Implication d'AIF dans la mort cellulaire et la physiologie mitochondriale : exemples dans la nécroptose intrinsèque et l'hématopoïèse : Implication of AIF in cell death and mitochondrial physiology : cases of intrinsic necroptosis and hematopoiesis. [Internet] [Doctoral dissertation]. Université Pierre et Marie Curie – Paris VI; 2014. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2014PA066314.

Council of Science Editors:

Cabon L. Implication d'AIF dans la mort cellulaire et la physiologie mitochondriale : exemples dans la nécroptose intrinsèque et l'hématopoïèse : Implication of AIF in cell death and mitochondrial physiology : cases of intrinsic necroptosis and hematopoiesis. [Doctoral Dissertation]. Université Pierre et Marie Curie – Paris VI; 2014. Available from: http://www.theses.fr/2014PA066314

10. Bertaux, Audrey. Influence du métabolisme mitochondrial dans l'hématopoïèse : Analyse de la réponse adaptative des cellules de la moelle osseuse et des thymocytes au dysfonctionnement de l’OXPHOS : Influence of mitochondrial metabolism in hematopoieisis : Analysis of the adaptative response of bone marrow cells and thymocytes to OXPHOS dysfunction.

Degree: Docteur es, Physiologie et Physiopathologie, 2018, Sorbonne université

URL: http://www.theses.fr/2018SORUS040

►

Les mitochondries sont des organelles qui jouent un rôle clé dans le métabolisme cellulaire en centralisant la production d'ATP à partir de nombreux substrats via… (more)

▼

Les mitochondries sont des organelles qui jouent un rôle clé dans le métabolisme cellulaire en centralisant la production d'ATP à partir de nombreux substrats via la phosphorylation oxydative (OXPHOS). Les réactions enzymatiques impliquées dans ce processus régulent la prolifération, la différenciation, l'activation et l'auto renouvellement cellulaire. Le but de mon travail a été d'identifier le rôle de l'OXPHOS dans l'hématopoïèse et les mécanismes d'adaptation métabolique des cellules sanguines de la moelle, des lymphocytes B et des thymocytes à la dysfonction mitochondriale. L'atout majeur de cette étude est la génération de deux modèles murins déficients pour les protéines mitochondriales AIF ou NDUFS4 dans le système hématopoïétique. Nous avons observé que l'absence de ces protéines entraine des dysfonctions de l'OXPHOS sévère (AIF KO) ou modérée (NDUFS4 KO), entrainant des anomalies dans le développement hématopoïétique. Dans les deux modèles, en réponse au stress métabolique induit par la dysfonction de l'OXPHOS, les cellules de moelle activent la glycolyse anaérobie et la biogenèse mitochondriale tandis que les thymocytes favorisent l'assimilation et la dégradation des acides gras. Cette étude multiparamétrique, incluant des approches in vivo, ex vivo et in vitro, souligne l'importance de l'OXPHOS et du métabolisme mitochondrial dans le développement hématopoïétique.

By integrating different biochemical pathways and generating energy in form of ATP, through the electron transfer associated to oxidative phosphorylation (OXPHOS), mitochondria play a key role in cellular metabolism. In the hematopoietic cells, the mitochondrial metabolism appears implicated in proliferation, differentiation, activation and self-renewal regulation. In this context, the aim of my PhD work was to unravel the response of bone marrow (BM) cells, B-cells and thymocytes to OXPHOS dysfunction. To do that, we have developed two original hematopoietic cell-specific murine models deficient in the mitochondrial proteins AIF or NDUFS4. Severe (AIF KO) or moderate (NDUFS4 KO) OXPHOS dysfunction leads to pleiotropic consequences on hematopoietic development, including pancytopenia, BM aplasia, alterations in the development of the B-cell and erythroid lineages and T-cell developmental blockade at the immature stage. Strikingly, in response to OXPHOS dysfunction, BM cells stimulate anaerobic glycolysis and mitochondrial biogenesis, whereas thymocytes favor the assimilation and degradation of fatty acids. Overall my work, which included in vivo, ex vivo and in vitro approaches, underlines the relevance of OXPHOS and mitochondrial metabolism in the development of the hematopoietic cells.

Advisors/Committee Members: Susin, Santos (thesis director).

Subjects/Keywords: Hématopoïèse; Métabolisme; Mitochondrie; AIF; Phosphorylation oxydative; Cellules souches; Hematopoiesis; Metabolism; Mitochondria; 572.4

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bertaux, A. (2018). Influence du métabolisme mitochondrial dans l'hématopoïèse : Analyse de la réponse adaptative des cellules de la moelle osseuse et des thymocytes au dysfonctionnement de l’OXPHOS : Influence of mitochondrial metabolism in hematopoieisis : Analysis of the adaptative response of bone marrow cells and thymocytes to OXPHOS dysfunction. (Doctoral Dissertation). Sorbonne université. Retrieved from http://www.theses.fr/2018SORUS040

Chicago Manual of Style (16^th Edition):

Bertaux, Audrey. “Influence du métabolisme mitochondrial dans l'hématopoïèse : Analyse de la réponse adaptative des cellules de la moelle osseuse et des thymocytes au dysfonctionnement de l’OXPHOS : Influence of mitochondrial metabolism in hematopoieisis : Analysis of the adaptative response of bone marrow cells and thymocytes to OXPHOS dysfunction.” 2018. Doctoral Dissertation, Sorbonne université. Accessed January 22, 2021. http://www.theses.fr/2018SORUS040.

MLA Handbook (7^th Edition):

Bertaux, Audrey. “Influence du métabolisme mitochondrial dans l'hématopoïèse : Analyse de la réponse adaptative des cellules de la moelle osseuse et des thymocytes au dysfonctionnement de l’OXPHOS : Influence of mitochondrial metabolism in hematopoieisis : Analysis of the adaptative response of bone marrow cells and thymocytes to OXPHOS dysfunction.” 2018. Web. 22 Jan 2021.

Vancouver:

Bertaux A. Influence du métabolisme mitochondrial dans l'hématopoïèse : Analyse de la réponse adaptative des cellules de la moelle osseuse et des thymocytes au dysfonctionnement de l’OXPHOS : Influence of mitochondrial metabolism in hematopoieisis : Analysis of the adaptative response of bone marrow cells and thymocytes to OXPHOS dysfunction. [Internet] [Doctoral dissertation]. Sorbonne université; 2018. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2018SORUS040.

Council of Science Editors:

Bertaux A. Influence du métabolisme mitochondrial dans l'hématopoïèse : Analyse de la réponse adaptative des cellules de la moelle osseuse et des thymocytes au dysfonctionnement de l’OXPHOS : Influence of mitochondrial metabolism in hematopoieisis : Analysis of the adaptative response of bone marrow cells and thymocytes to OXPHOS dysfunction. [Doctoral Dissertation]. Sorbonne université; 2018. Available from: http://www.theses.fr/2018SORUS040

11. Banerjee, Hridesh. Role of AIF in T cell development and function;.

Degree: 2010, Jawaharlal Nehru University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/20956

References p.102-129 Advisors/Committee Members: Rath, Satyajit.

Subjects/Keywords:

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Banerjee, H. (2010). Role of AIF in T cell development and function;. (Thesis). Jawaharlal Nehru University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/20956

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Banerjee, Hridesh. “Role of AIF in T cell development and function;.” 2010. Thesis, Jawaharlal Nehru University. Accessed January 22, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/20956.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Banerjee, Hridesh. “Role of AIF in T cell development and function;.” 2010. Web. 22 Jan 2021.

Vancouver:

Banerjee H. Role of AIF in T cell development and function;. [Internet] [Thesis]. Jawaharlal Nehru University; 2010. [cited 2021 Jan 22]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/20956.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Banerjee H. Role of AIF in T cell development and function;. [Thesis]. Jawaharlal Nehru University; 2010. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/20956

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

12. Lenkeit, Julia Susanne. Expression und interactions of regulators of apoptosis in human melanocytes and melanoma cells.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8519

► Melanoma is a highly malignant tumor which is resistant to most usual therapies. This resistance is mainly due to a reduction of apoptosis in melanoma… (more)

▼ Melanoma is a highly malignant tumor which is resistant to most usual therapies. This resistance is mainly due to a reduction of apoptosis in melanoma cells. Aim of this study was to analyze specific pathway steps of apoptosis in normal melanocytes and malignant melanoma cells. We therefore quantified and compared the efficacy of apoptosis inducing stimuli on melanocytes and melanoma cells. Furthermore we analyzed changes in expression of regulators of apoptosis in both cell types. Since the melanoma cells showed partially resistances to the induction of apoptosis by CH-11, IFN-γ (Interferon-γ), LPS (lipopolysaccharide) und TNF-α (tumor necrosis factor-α) we could distinguish resistant and sensitive melanoma cell lines. In contrast to melanocytes we found in all examined melanoma cells a stronger expression of IAPs (inhibitors of apoptosis proteins), of cFLIP (cellular FLICE inhibitory protein) and of Smac (second mitochondria-derived activator of caspases). However, Livin was not expressed in all melanoma cell lines. The overall increased expression of IAP in melanoma cells may be explained by a missing iNOS (inducible nitric oxide synthase)-expression in these cells. On the other hand, the pro-apoptotic AIF (apoptosis inducing factor) was expressed much weaker in melanoma cells than in normal melanocytes. As we found strong distinctions of expression of anti- and proapoptotic proteins between sensitive and resistant melanoma cells, we can formulate several hypothesis that may explain how resistance of melanoma cells to induction of apoptosis may have developed. One explanation could be an overexpression of the anti-apoptotic protein Survivin. We found a reciprocal expression of antiapoptotic Survivin and of proapoptotic Smac. Within the resistant melanoma cell lines we observed a strong expression of Survivin and a weak expression of Smac. Survivin inhibits the apoptotic impact of Smac by interacting with XIAP (X-linked inhibitor of apoptosis protein). Furthermore it inhibits AIF- expression and antagonizes the pro-apoptotic effect of AIF. Yet, this mechanism does not completely explain the development of resistance of melanocytes towards apoptosis induction. AIF and Smac showed reciprocal expression for which up to today there has not been found a proper explanation. The reciprocal expression of Livin and Smac on the other hand has been described by others previously. In this study, melanoma cell lines with strong Livin expression showed only mild Smac expression. Livin is already being used as a diagnostic marker. Another reason for the development of resistance to apoptosis may be the high cFLIP expression on melanoma cells. When showing a weak expression of cFLIP all but one of the melanoma cell lines we investigated, were found to be sensitive to stimuli of apoptosis. In order to investigate the effect of CD95L-overexpression on apoptosis regulation we used a tetracyclin regulated expression system. SK-Mel-13, a melanoma cell line that is transfected with the gene encoding for CD95L, was used for this… Advisors/Committee Members: w (gender), Priv.-Doz. Dr. rer. nat. J. Eberle (firstReferee), Prof. Dr. med. W. Harth (furtherReferee), Priv.-Doz. Dr. A. Paschen (furtherReferee).

Subjects/Keywords: apoptosis; regulators of apoptosis; IAPs; FLIP; Smac; AIF; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lenkeit, J. S. (2010). Expression und interactions of regulators of apoptosis in human melanocytes and melanoma cells. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lenkeit, Julia Susanne. “Expression und interactions of regulators of apoptosis in human melanocytes and melanoma cells.” 2010. Thesis, Freie Universität Berlin. Accessed January 22, 2021. http://dx.doi.org/10.17169/refubium-8519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lenkeit, Julia Susanne. “Expression und interactions of regulators of apoptosis in human melanocytes and melanoma cells.” 2010. Web. 22 Jan 2021.

Vancouver:

Lenkeit JS. Expression und interactions of regulators of apoptosis in human melanocytes and melanoma cells. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Jan 22]. Available from: http://dx.doi.org/10.17169/refubium-8519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lenkeit JS. Expression und interactions of regulators of apoptosis in human melanocytes and melanoma cells. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-8519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

13. Larsson, Jessica. Alternativa Investeringsfonder : Definitions- och gränsdragningsproblematik.

Degree: Law, 2014, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219450

Subjects/Keywords: AIF; Alternativa investeringsfonder; aktiemarknadsrätt; AIFMD; Förvaltare av alternativa investeringsfonder

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Larsson, J. (2014). Alternativa Investeringsfonder : Definitions- och gränsdragningsproblematik. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219450

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Larsson, Jessica. “Alternativa Investeringsfonder : Definitions- och gränsdragningsproblematik.” 2014. Thesis, Uppsala University. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219450.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Larsson, Jessica. “Alternativa Investeringsfonder : Definitions- och gränsdragningsproblematik.” 2014. Web. 22 Jan 2021.

Vancouver:

Larsson J. Alternativa Investeringsfonder : Definitions- och gränsdragningsproblematik. [Internet] [Thesis]. Uppsala University; 2014. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219450.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Larsson J. Alternativa Investeringsfonder : Definitions- och gränsdragningsproblematik. [Thesis]. Uppsala University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219450

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Liljenberg, Helena. Marknadsföring av alternativa investeringsfonder till icke-professionella investerare : En analys av regleringens ändamålsenlighet.

Degree: Commercial and Business Law, 2019, Linköping UniversityLinköping University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159042

► I kölvattnet av finanskrisen 2008 har regleringen på det finansiella området ökat markant. En del av den finansiella marknaden som varit nästintill oreglerad innan… (more)

▼ I kölvattnet av finanskrisen 2008 har regleringen på det finansiella området ökat markant. En del av den finansiella marknaden som varit nästintill oreglerad innan 2008 års finanskris är verksamheten för förvaltare av alternativa investeringsfonder (AIF-förvaltare). Sedan 2011 omfattas dock denna verksamhet av reglering på såväl unionsrättslig nivå, i och med Europaparlamentets och rådets direktiv 2011/61/EU, som på nationell nivå, i och med direktivets implementering i svensk rätt genom lagen (2013:561) om förvaltare av alternativa investeringsfonder (LAIF). Motiven för reglering på det finansiella området i allmänhet och för AIF-förvaltare i synnerhet har varit flera, emellertid är säkerställande av stabilitet i det finansiella systemet det mest framträdande. I uppsatsen undersöks huruvida regleringen avseende marknadsföring av AIF-fonder till icke-professionella investerare är ändamålsenlig. För att besvara frågeställningen om regleringens ändamålsenlighet identifieras LAIF:s övergripande såväl som underliggande ändamål och används som utvärderingsvariabel. Med hjälp av utvärderingsvariabeln undersöks i vilken utsträckning de övergripande ändamålen tillgodoses med regleringens utformning. Regleringen av marknadsföring av AIF-fonder till icke-professionella investerare skiljer sig åt. Dessa skillnader föranleds av motivet att skydda investerare, ty olika AIF-fonder har olika starkt investerarskydd. Investerarskyddet vid marknadsföring av AIF-fonder tar sig uttryck genom bestämmelser om informationsgivning och produktingripande åtgärder. Kraven på informationsgivning ämnar hjälpa investerare att fatta väl övervägda och kvalitativt bättre investeringsbeslut. I uppsatsen påvisas dock att omfattande informationsgivning, något som kraven på informationsgivning i LAIF föranleder, till stora delar är ett ineffektivt skydd emedan informationsgivningen inte sällan leder till informationsöverflöd. Anledningen härför är investerares, främst konsumenters, tillkortakommanden i form av bristande kognitiv förmåga. Vidare försvårar den befintliga investerarklassificeringen för investerare att erhålla ett adekvat skydd genom informationsgivning. Klassificeringen av investerare medför att även institutionella investerare faller in under kategorin ”icke-professionella investerare” trots att skyddsnivån i regleringen är anpassad efter konsumenters skyddsbehov. De produktingripande åtgärderna, å andra sidan, förhindrar marknadsföring av AIF-fonder, i form av riskkapitalfonder, till konsumenter med anledning av att dessa AIF-fonder bedöms för riskfyllda för konsumenter att investera i. Utformningen av de produktingripande åtgärderna i LAIF får dock följden att erhållet skydd beror på personlig status, eftersom det skydd konsumenterna erhåller utgörs av en miniminivå för investering. I uppsatsen ifrågasätts således investerarskyddets utformning vid marknadsföring av AIF-fonder i LAIF och hur långt detta skydd kan sträcka sig i förhållande till andra i lagen beaktansvärda intressen. Till diskussionen är även…

Subjects/Keywords: Alternativa investeringsfonder; AIF-Fonder; ETF-fonder; specialfonder; riskkapitalfonder; marknadsföring; icke-professionella investerare; AIFMD; LAIF; ändamål; ändamålsenlighet; de lege ferenda; Law; Juridik

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liljenberg, H. (2019). Marknadsföring av alternativa investeringsfonder till icke-professionella investerare : En analys av regleringens ändamålsenlighet. (Thesis). Linköping UniversityLinköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159042

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liljenberg, Helena. “Marknadsföring av alternativa investeringsfonder till icke-professionella investerare : En analys av regleringens ändamålsenlighet.” 2019. Thesis, Linköping UniversityLinköping University. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159042.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liljenberg, Helena. “Marknadsföring av alternativa investeringsfonder till icke-professionella investerare : En analys av regleringens ändamålsenlighet.” 2019. Web. 22 Jan 2021.

Vancouver:

Liljenberg H. Marknadsföring av alternativa investeringsfonder till icke-professionella investerare : En analys av regleringens ändamålsenlighet. [Internet] [Thesis]. Linköping UniversityLinköping University; 2019. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159042.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liljenberg H. Marknadsföring av alternativa investeringsfonder till icke-professionella investerare : En analys av regleringens ändamålsenlighet. [Thesis]. Linköping UniversityLinköping University; 2019. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-159042

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

15. Nowitzki, Kristina M. The response of Allograft inflammatory factor-1 to neurotoxic injury, and its role as a secreted protein.

Degree: PhD, Biochemistry & Molecular Biology, 2008, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/147701/rec/7182

► Allograft inflammatory factor-1 (AIF-1) is an evolutionary conserved protein important to inflammatory responses throughout the body including that of microglia in the central nervous system… (more)

▼ Allograft inflammatory factor-1 (AIF-1) is an evolutionary conserved protein important to inflammatory responses throughout the body including that of microglia in the central nervous system (CNS). In addition to critical intracellular roles in the activation of microglia and macrophages, AIF-1 can be secreted by these cells in response to inflammatory signals as well as soluble signals released by dying neurons. In response to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, we found increased levels of AIF-1 expression in cells clustered in the substantia nigra pars compacta (SNpc), the site of dopaminergic cell death. The number of these AIF-1 bright cells continued to increase even after neuronal cell death was complete. This increased expression of AIF-1 was restricted to resident microglia; flow cytometric analysis showed that infiltrating CD45hi leukocytes did not express high levels of AIF-1. Analysis of microglia ex vivo demonstrated the secretion of AIF-1 by these cells, lending support to a role for this molecule as an extracellular participant in the microglia response to neurotoxicity. To define a functional role for extracellular AIF-1 in CNS inflammation, we produced a recombinant mouse AIF-1 protein using a mammalian expression system and tested the functional activity of this protein both in vitro and in vivo. Intracerebral injection of recombinant AIF-1 into both the mouse striatum and midbrain led to activation of microglia and astrocytes near the site of injection, which was more prolonged and widespread compared to controls. Interestingly, ex vivo analysis of microglia showed no significant changes in inflammatory cytokine secretion whereas human peripheral blood mononuclear cells showed altered patterns in the secretion of TNF, IL-6, MCP-1, IL-8, and RANTES. This work shows for the first time that AIF-1 can be secreted by adult murine microglia and describes a new role for AIF-1 as a secreted molecule that can peripherally and local Advisors/Committee Members: Tokes, Zoltan A. (Committee Chair), Weiner, Leslie P. (Committee Member), Garner, Judy A. (Committee Member), Mosteller, Raymond (Committee Member).

Subjects/Keywords: migroglia; MPTP; AIF-1; Allograft inflammatory factor-1

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APA (6^th Edition):

Nowitzki, K. M. (2008). The response of Allograft inflammatory factor-1 to neurotoxic injury, and its role as a secreted protein. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/147701/rec/7182

Chicago Manual of Style (16^th Edition):

Nowitzki, Kristina M. “The response of Allograft inflammatory factor-1 to neurotoxic injury, and its role as a secreted protein.” 2008. Doctoral Dissertation, University of Southern California. Accessed January 22, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/147701/rec/7182.

MLA Handbook (7^th Edition):

Nowitzki, Kristina M. “The response of Allograft inflammatory factor-1 to neurotoxic injury, and its role as a secreted protein.” 2008. Web. 22 Jan 2021.

Vancouver:

Nowitzki KM. The response of Allograft inflammatory factor-1 to neurotoxic injury, and its role as a secreted protein. [Internet] [Doctoral dissertation]. University of Southern California; 2008. [cited 2021 Jan 22]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/147701/rec/7182.

Council of Science Editors:

Nowitzki KM. The response of Allograft inflammatory factor-1 to neurotoxic injury, and its role as a secreted protein. [Doctoral Dissertation]. University of Southern California; 2008. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/147701/rec/7182

University of Arizona

16. Whatcott, Clifford Jason. The Role of ADP-Ribosylation in Mitochondria-Mediated Cell Death .

Degree: 2009, University of Arizona

URL: http://hdl.handle.net/10150/195141

► Poly(ADP)ribose (PAR) metabolism is essential to many cellular functions, including the maintenance of genomic integrity, the regulation of cell death mechanisms, as well as the… (more)

▼ Poly(ADP)ribose (PAR) metabolism is essential to many cellular functions, including the maintenance of genomic integrity, the regulation of cell death mechanisms, as well as the regulation of gene expression. Recent work has uncovered many new players in the expanding effort to understand PAR metabolism and its cellular impact. PARP-1, the prototypical poly(ADP)ribose polymerase, was the first to be discovered, and has since been shown to be vital in the cellular response to DNA damage. Indeed, one report demonstrating that PARP-1 activation is required for apoptosis-inducing factor (AIF) release from mitochondria uncovered a novel link between DNA damage and signaling for cell death. The events following PARP activation, leading to signaling for AIF release, however, are still poorly understood. Based on our observations, we have developed a model to explain the nuclear/mitochondrial crosstalk that occurs following PARP activation. The work presented here answers several important questions regarding the relationship between ADP-ribose metabolism and mitochondria, including the role of PAR in signaling for the release of AIF, the presence of ADP-ribose metabolism protein members in mitochondria, and mitochondrial transcriptional effects following PARP activation. This work presents several novel findings, including the first report of a mitochondrial matrix isoform of poly(ADP-ribose) glycohydrolase (PARG) as well as direct evidence of mitochondria-associated PARP activity. Furthermore, it provides evidence for a novel effect of PARP-1 activation, in the specific transcriptional upregulation of the mitochondrial gene, NADH dehydrogenase, subunit 1 (ND1). Our data is consistent with the hypothesis that uncontrolled PARP activity results in energy metabolism dysfunction and cell death. Furthermore, it supports a model in which PARP activity is required for normal transcriptional responses in mitochondria following DNA damage. In total, this report adds to the body of work outlining the roles of PARP following DNA damage recognition and activation, demonstrating that ADP-ribose metabolism plays an important role in cell death regulation by both direct and indirect means. Advisors/Committee Members: Jacobson, Myron K (advisor), Briehl, Margaret (committeemember), Ghosh, Indraneel (committeemember), Hurley, Laurence (committeemember), Maggiora, Gerald (committeemember).

Subjects/Keywords: ADP-ribosylation; AIF; Mitochondria; ND1; PARG; PARP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Whatcott, C. J. (2009). The Role of ADP-Ribosylation in Mitochondria-Mediated Cell Death . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/195141

Chicago Manual of Style (16^th Edition):

Whatcott, Clifford Jason. “The Role of ADP-Ribosylation in Mitochondria-Mediated Cell Death .” 2009. Doctoral Dissertation, University of Arizona. Accessed January 22, 2021. http://hdl.handle.net/10150/195141.

MLA Handbook (7^th Edition):

Whatcott, Clifford Jason. “The Role of ADP-Ribosylation in Mitochondria-Mediated Cell Death .” 2009. Web. 22 Jan 2021.

Vancouver:

Whatcott CJ. The Role of ADP-Ribosylation in Mitochondria-Mediated Cell Death . [Internet] [Doctoral dissertation]. University of Arizona; 2009. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10150/195141.

Council of Science Editors:

Whatcott CJ. The Role of ADP-Ribosylation in Mitochondria-Mediated Cell Death . [Doctoral Dissertation]. University of Arizona; 2009. Available from: http://hdl.handle.net/10150/195141

17. Wegman, Hanna Elisabeth. Investor protection: towards additional EU regulation of investment funds?.

Degree: 2016, Faculty of Law, Leiden Univesity

URL: http://hdl.handle.net/1887/38038

► The expansion of the fund industry has been one of the most notable trends in the financial markets of recent years. Not only has the… (more)

Subjects/Keywords: Investment funds; AIFM; CITSAIF; Investor protection; Transparency; Depositary; UCITS; AIF; Investment funds; AIFM; CITSAIF; Investor protection; Transparency; Depositary; UCITS; AIF

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wegman, H. E. (2016). Investor protection: towards additional EU regulation of investment funds?. (Doctoral Dissertation). Faculty of Law, Leiden Univesity. Retrieved from http://hdl.handle.net/1887/38038

Chicago Manual of Style (16^th Edition):

Wegman, Hanna Elisabeth. “Investor protection: towards additional EU regulation of investment funds?.” 2016. Doctoral Dissertation, Faculty of Law, Leiden Univesity. Accessed January 22, 2021. http://hdl.handle.net/1887/38038.

MLA Handbook (7^th Edition):

Wegman, Hanna Elisabeth. “Investor protection: towards additional EU regulation of investment funds?.” 2016. Web. 22 Jan 2021.

Vancouver:

Wegman HE. Investor protection: towards additional EU regulation of investment funds?. [Internet] [Doctoral dissertation]. Faculty of Law, Leiden Univesity; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1887/38038.

Council of Science Editors:

Wegman HE. Investor protection: towards additional EU regulation of investment funds?. [Doctoral Dissertation]. Faculty of Law, Leiden Univesity; 2016. Available from: http://hdl.handle.net/1887/38038

Australian National University

18. Jordan, Lucas Tom. A Few Daring Men: Stealth Raiders of the Australian Infantry, 1918 .

Degree: 2016, Australian National University

URL: http://hdl.handle.net/1885/116798

► In 1918 a few daring low ranking Australian infantrymen, alone among all the armies on the Western Front, initiated stealth raids without orders. This thesis… (more)

▼ In 1918 a few daring low ranking Australian infantrymen, alone among all the armies on the Western Front, initiated stealth raids without orders. This thesis examines this distinct but neglected group. Stealth raiders killed Germans, captured prisoners and advanced the line. They were held in high regard by other men of the lower ranks and feared by the Germans facing them. Since the official historian CEW Bean laid down his pen in 1942, historians have not considered the distinctive character and motivation of these men. The premise of this thesis is that such men should not be forgotten. Bean called stealth raids, “peaceful penetration” but this thesis argues that the name is inappropriate because “peaceful penetration” was a term that higher command used, sometimes for actions other than stealth raids. The term did not emanate from the original stealth raiders. The thesis is the most comprehensive account yet written on stealth raids. Using first-hand accounts in official archives and private records in Australia and overseas, the thesis asks who were stealth raiders? Why did they do it? How significant were their actions? The thesis answers these questions using a historical narrative and analysis that describes all the stealth raids uncovered during the research. The account considers the stealth raiders’ war experience and training, the unprecedented topographic and environmental conditions at the front, and the quality and morale of the German Army in 1918. It also goes beyond these to consider the influence of Australian civil society and in particular the “bush ethos”. The thesis is original not only for its primary narrative, but also because it undermines the contemporary fashion of dismissing the importance of bush skills and the bush ethos in the AIF. It demonstrates that bush skills gave some stealth raiders an edge and that the bush ethos, with its high premium on resourcefulness and initiative contributed to making stealth raids a distinctively Australian phenomenon.

Subjects/Keywords: A Few Daring Men; Stealth Raiders; Stealth Raids; peaceful penetration; Australian Infantry 1918; Australian Imperial Force (AIF); Western Front; 1918; bush ethos

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APA (6^th Edition):

Jordan, L. T. (2016). A Few Daring Men: Stealth Raiders of the Australian Infantry, 1918 . (Thesis). Australian National University. Retrieved from http://hdl.handle.net/1885/116798

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jordan, Lucas Tom. “A Few Daring Men: Stealth Raiders of the Australian Infantry, 1918 .” 2016. Thesis, Australian National University. Accessed January 22, 2021. http://hdl.handle.net/1885/116798.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jordan, Lucas Tom. “A Few Daring Men: Stealth Raiders of the Australian Infantry, 1918 .” 2016. Web. 22 Jan 2021.

Vancouver:

Jordan LT. A Few Daring Men: Stealth Raiders of the Australian Infantry, 1918 . [Internet] [Thesis]. Australian National University; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1885/116798.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jordan LT. A Few Daring Men: Stealth Raiders of the Australian Infantry, 1918 . [Thesis]. Australian National University; 2016. Available from: http://hdl.handle.net/1885/116798

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Lorraine

19. Louis, Jean-Sébastien. Développements en IRM quantitative de perfusion pour le diagnostic de fibrose myocardique : Developments in quantitative perfusion MRI for the diagnostic of myocardial fibrosis.

Degree: Docteur es, Sciences de la vie et de la santé, 2020, Université de Lorraine

URL: http://www.theses.fr/2020LORR0061

►

L’insuffisance cardiaque est un enjeu de santé publique majeur dans les pays occidentaux. Ce syndrome complexe peut être la résultante de pathologies sous-jacentes du myocarde… (more)

▼

L’insuffisance cardiaque est un enjeu de santé publique majeur dans les pays occidentaux. Ce syndrome complexe peut être la résultante de pathologies sous-jacentes du myocarde comme le dépôt de fibrose, diffusant sur l’ensemble du tissu myocardique. L’Imagerie par Résonance Magnétique (IRM) est la modalité de référence dans l’exploration clinique des tissus mous du tissu myocardique. Plusieurs biomarqueurs d’IRM comme le temps de relaxation T1 ou encore la quantification du volume extracellulaire (ECV) ont révélé leur utilité clinique dans le diagnostic de fibroses localisées. L’IRM avec injection de produit de contraste a également montré son fort pouvoir diagnostic dans la détection de lésions post-infarctus. Le suivi dynamique de rehaussement de contraste (DCE) semble être une technique prometteuse dans la différenciation de zones dont la perfusion/perméabilité tissulaire est altérée par un dépôt fibrotique. Dans ces travaux de thèse, nous sommes partis de l’hypothèse que la quantification de la perméabilité cardiaque et l’extraction du volume extracellulaire extravasculaire Ve, permettraient la détection de lésions diffuses avec comme corolaire un raccourcissement de la durée totale d’examen pour l’estimation de l’ECV. Ce mémoire présente dans un premier temps, les travaux méthodologiques mis en œuvre pour permettre l’analyse quantitative DCE myocardique. Pour cela, une méthode de reconstruction de fonction d’entrée artérielle est présentée afin de permettre la quantification DCE sans séquence ou protocole spécifique. Un algorithme de recalage des images dynamiques est décrit, afin de rendre possible l’analyse sous forme de cartes paramétriques. Les conditions d’acquisition des données ont également été étudiées par simulations de Monte-Carlo et cela a permis de proposer un protocole le plus court possible pour l’estimation de Ve. Dans un second temps, les résultats obtenus par analyse DCE ont été comparés aux résultats obtenus par analyse ECV dans le diagnostic de fibrose diffuse. Une corrélation entre ces deux paramètres a été démontrée sur un groupe de 12 patients présentant un prolapsus de la valve mitrale. Un test de permutation a permis de séparer l’échantillon en deux sous-groupes de manière équivalente à l’ECV. Ces travaux de thèse proposent un flux de post traitement complet d’analyse quantitative DCE myocardique et ouvrent la voie à une estimation plus rapide du volume extracellulaire pour la quantification de la fibrose diffuse myocardique.

Heart failure represents a major public health issue in western world. It is a complex syndrome that could be the cause and/or the consequence of underlying pathologies such interstitial diffuse fibrosis. Magnetic Resonance Imaging (MRI) is the reference imaging modality for soft tissue assessment and especially the myocardium. Several imaging biomarkers such relaxation time T1 or extracellular volume fraction (ECV) have proven their diagnostic power in term of sensitivity and specificity. MRI with contrast agent injection has also demonstrated its usefulness in…

Advisors/Committee Members: Chillou, Christian de (thesis director), Beaumont, Marine (thesis director).

Subjects/Keywords: Imagerie par Résonance Magnétique (IRM); Caractérisation myocardique; Volume extracellulaire (ECV); Fibrose; Rehaussement dynamique de contraste (DCE); Quantification de perfusion; Perméabilité; AIF; Recalage d’images dynamique de perfusion; Magnetic Resonance Imaging (MRI); Myocardial characterization; Extracellular Volume fraction (ECV); Fibrosis; Dynamic Contrast Enhancement (DCE); Perfusion quantification; Permeability; AIF; Perfusion images registration; 616.075 48; 616.120 7548

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Louis, J. (2020). Développements en IRM quantitative de perfusion pour le diagnostic de fibrose myocardique : Developments in quantitative perfusion MRI for the diagnostic of myocardial fibrosis. (Doctoral Dissertation). Université de Lorraine. Retrieved from http://www.theses.fr/2020LORR0061

Chicago Manual of Style (16^th Edition):

Louis, Jean-Sébastien. “Développements en IRM quantitative de perfusion pour le diagnostic de fibrose myocardique : Developments in quantitative perfusion MRI for the diagnostic of myocardial fibrosis.” 2020. Doctoral Dissertation, Université de Lorraine. Accessed January 22, 2021. http://www.theses.fr/2020LORR0061.

MLA Handbook (7^th Edition):

Louis, Jean-Sébastien. “Développements en IRM quantitative de perfusion pour le diagnostic de fibrose myocardique : Developments in quantitative perfusion MRI for the diagnostic of myocardial fibrosis.” 2020. Web. 22 Jan 2021.

Vancouver:

Louis J. Développements en IRM quantitative de perfusion pour le diagnostic de fibrose myocardique : Developments in quantitative perfusion MRI for the diagnostic of myocardial fibrosis. [Internet] [Doctoral dissertation]. Université de Lorraine; 2020. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2020LORR0061.

Council of Science Editors:

Louis J. Développements en IRM quantitative de perfusion pour le diagnostic de fibrose myocardique : Developments in quantitative perfusion MRI for the diagnostic of myocardial fibrosis. [Doctoral Dissertation]. Université de Lorraine; 2020. Available from: http://www.theses.fr/2020LORR0061

20. Majlund, Åsa. Konsekvensanalys av olika förändringar i intäktsrams-regleringen avseende hänsyn till leveranssäkerhet.

Degree: Electromagnetic Engineering, 2018, KTH

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-228390

► The distribution of electricity is a natural monopoly. The infrastructure of the electricity grid is divided into areas and the distribution system operator (DSO)… (more)

▼ The distribution of electricity is a natural monopoly. The infrastructure of the electricity grid is divided into areas and the distribution system operator (DSO) has concession for the distribution of the defined area. The concession is governed by laws and regulation.The Swedish Energy Markets Inspectorate (Ei) is the national regulatory authority. The continuity of supply of electricity is a part of the regulation. The incentive is given by a revenue cap regulation which may result in a reward or penalty.The performance indicators are a measure of the continuity of supply and used in the calculation of the revenue cap regulation.The Master thesis aims to specify the possible consequences for the electricity distribution system operators and their customers utilizing the electricity grid in case of a change of the current methods used to measure the continuity of supply in Sweden.With the current methods, the Ei regulation for year 2016-2019, is the continuity of supply in the local electrical grid estimated from a view where each disruption is treated equal and therefore is SAIFI and SAIDI used. In the regional electrical grid is another method used to measure the continuity of supply, estimated from a view where the loss of supplied energy is considered, therefore uses PNS and ENS. In the documentation is the term ILE used for ENS and ILEffekt for PNS.The Master thesis is constructed to analyze new performance indicators for the local and regional distribution grid. The new performance indicator is the mathematically instrument to measure the continuity of supply and is supported by analytically advantages and disadvantages.The result shows the choice of performance indicators cause a great impact in the revenue cap regulation. AIT, AIF corresponds to ENS and PNS, respectively, divided by power. The three most important results are given by:1. Mathematical and theoretical results show that ENS, PNS are not good indicators individually or in combination with SAIDI, SAIFI and CEMI4 as power consumption within each customer group varies in the local electrical grid.In the regional electrical grid, power consumption may also vary between the norm period and the supervisory period, which means that ENS, PNS can sometimes be misleading.2. The inclusion of power disruption over 12 hours generate stronger incentives in the regulation. Because it requires long term planning to avoid interruptions exceeding 12 hours. The difference is shown mainly in local electrical grid with the indicators SAIDI, SAIFI and CEMI4 and gives a slight increase in rewards in the regulation. This affects the DSO’s and their customers with a marginal difference.3. In the short term, the introduction of AIT, AIF as quality indicators means that customers who consume more power within their customer group get higher-value interruptions. An interruption of a high-consumption customer would then be prioritized compared to a customer with a lower consumption. One way to counteract this is to use CEMI4, in order to capture these customers'…

Subjects/Keywords: Continuity of supply; SAIFI; SAIDI; PNS; ENS; AIF; AIT; Leveranssäkerhet; SAIDI; SAIFI; ILE; ILEffekt; AIT; AIF; Engineering and Technology; Teknik och teknologier

…66 Tabell 8: Skäl till att använda AIT, AIF som mätmetod för lokalt nät. ............ 67… …h. ...................................................... 35 Figur 10: AIT och AIF för 3… …kvalitetsjustering för AIT, AIF för 3 min-12 h avbrott och avbrott längre än 12 h och SAIDI, SAIFI och… …36 Figur 12: Skillnad i kvalitetsjustering för högspänningskunder med AIT, AIF för 3 min-12… …indikatorerna ges AIT, AIF för avbrott som varar 3 min-12 h och överstiger 12 h…

14 more images…

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APA (6^th Edition):

Majlund, �. (2018). Konsekvensanalys av olika förändringar i intäktsrams-regleringen avseende hänsyn till leveranssäkerhet. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-228390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Majlund, Åsa. “Konsekvensanalys av olika förändringar i intäktsrams-regleringen avseende hänsyn till leveranssäkerhet.” 2018. Thesis, KTH. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-228390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Majlund, Åsa. “Konsekvensanalys av olika förändringar i intäktsrams-regleringen avseende hänsyn till leveranssäkerhet.” 2018. Web. 22 Jan 2021.

Vancouver:

Majlund �. Konsekvensanalys av olika förändringar i intäktsrams-regleringen avseende hänsyn till leveranssäkerhet. [Internet] [Thesis]. KTH; 2018. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-228390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Majlund �. Konsekvensanalys av olika förändringar i intäktsrams-regleringen avseende hänsyn till leveranssäkerhet. [Thesis]. KTH; 2018. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-228390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Medical Center

21. Ragan, Dustin K. Measurement of the vascular input function in mice for DCE-MRI.

Degree: PhD, 2010, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/11

► DCE-MRI is an important technique in the study of small animal cancer models because its sensitivity to vascular changes opens the possibility of quantitative assessment… (more)

▼ DCE-MRI is an important technique in the study of small animal cancer models because its sensitivity to vascular changes opens the possibility of quantitative assessment of early therapeutic response. However, extraction of physiologically descriptive parameters from DCE-MRI data relies upon measurement of the vascular input function (VIF), which represents the contrast agent concentration time course in the blood plasma. This is difficult in small animal models due to artifacts associated with partial volume, inflow enhancement, and the limited temporal resolution achievable with MR imaging. In this work, the development of a suite of techniques for high temporal resolution, artifact resistant measurement of the VIF in mice is described. One obstacle in VIF measurement is inflow enhancement, which decreases the sensitivity of the MR signal to the presence of contrast agent. Because the traditional techniques used to suppress inflow enhancement degrade the achievable spatiotemporal resolution of the pulse sequence, improvements can be achieved by reducing the time required for the suppression. Thus, a novel RF pulse which provides spatial presaturation contemporaneously with the RF excitation was implemented and evaluated. This maximizes the achievable temporal resolution by removing the additional RF and gradient pulses typically required for suppression of inflow enhancement. A second challenge is achieving the temporal resolution required for accurate characterization of the VIF, which exceeds what can be achieved with conventional imaging techniques while maintaining adequate spatial resolution and tumor coverage. Thus, an anatomically constrained reconstruction strategy was developed that allows for sampling of the VIF at extremely high acceleration factors, permitting capture of the initial pass of the contrast agent in mice. Simulation, phantom, and in vivo validation of all components were performed. Finally, the two components were used to perform VIF measurement in the murine heart. An in vivo study of the VIF reproducibility was performed, and an improvement in the measured injection-to-injection variation was observed. This will lead to improvements in the reliability of quantitative DCE-MRI measurements and increase their sensitivity. Advisors/Committee Members: James A. Bankson, John D. Hazle, Edward F. Jackson.

Subjects/Keywords: magnetic resonance imaging; DCE-MRI; VIF; AIF; small animal imaging; constrained reconstruction; flow enhancement; reproducibility; Medical Biophysics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ragan, D. K. (2010). Measurement of the vascular input function in mice for DCE-MRI. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/11

Chicago Manual of Style (16^th Edition):

Ragan, Dustin K. “Measurement of the vascular input function in mice for DCE-MRI.” 2010. Doctoral Dissertation, Texas Medical Center. Accessed January 22, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/11.

MLA Handbook (7^th Edition):

Ragan, Dustin K. “Measurement of the vascular input function in mice for DCE-MRI.” 2010. Web. 22 Jan 2021.

Vancouver:

Ragan DK. Measurement of the vascular input function in mice for DCE-MRI. [Internet] [Doctoral dissertation]. Texas Medical Center; 2010. [cited 2021 Jan 22]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/11.

Council of Science Editors:

Ragan DK. Measurement of the vascular input function in mice for DCE-MRI. [Doctoral Dissertation]. Texas Medical Center; 2010. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/11

Freie Universität Berlin

22. Keil, Claudia. Control of cell death by interactions between proteins involved in poly(ADP- ribose) metabolism.

Degree: 2006, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10846

► Poly (ADP-ribosyl)ation is a posttranslational modification, known to be involved in several cellular processes as regulation of cell cycle, DNA repair and cell death. While… (more)

▼ Poly (ADP-ribosyl)ation is a posttranslational modification, known to be involved in several cellular processes as regulation of cell cycle, DNA repair and cell death. While synthesis of poly (ADP-ribose) (PAR) and the function of Poly (ADP-ribose) polymerases (PARPs) were studied extensivly, only little is known about the polymere degrading enzyme Poly (ADP-ribose) glycohydrolase (PARG). First aim of this study was the identification of PARG interacting proteins. Further characterizations were intended to provide more insightes into the cellular functions of the PARG. Initially, the human PARG cDNA from the cancer cell line HeLa S3 was cloned. The analysis of the primary protein structure revealed the presence of all amino acids, essential for cellular distribution and the mechanism of catalysis. For the first time human PARG, catalytic domain (PARG65) as well as full length protein (PARG110), were expressed as soluble polyhistidin tagged fusion proteins in E. coli. Purification of the catalytic domain of PARG using Ni-NTA affinity chromatography enabled the generation of polyclonal antibodies directed against human PARG. Since purification of the full length PARG using Ni-NTA affinity chromatography was impossible, an affinity matrix composed of sepharose beads covalently linked to gallotannins, which are described as PARG inhibitors, was established. Subsequently, interactions between gallotannin sepharose immobilized PARG and other nuclear proteins were studied. A direct protein protein interaction between the enzymes PARP-1 and PARG was demonstrated. Using deletion mutants of both proteins the automodification domain of PARP-1 and the catalytic domain of PARG were identified as interacting regions. Functional experiments indicated that PARG downregulates the enzymatic activity of nuclear PARP-1. In addition, PARG interacts with X-ray repair cross-complementing 1 (XRCC1), a DNA repair factor which is recruited by PARP-1. To study the impact of XRCC1 on PAR metabolism and regulation of cell death hamster ovary cell lines either deficient in XRCC1 (EM9-V) or overexpressing XRCC1 (EM9-XH) were used. Treatment with supralethal doses of the alkylating agent MNNG caused a considerable accumulation of PAR only in EM9-XH cells. Consequently, MNNG triggered in XRCC1- proficient cells the translocation of apoptosis inducing factor (AIF) from mitochondria to the nucleus. This was followed by nuclear shrinkage and caspase-independent cell death. In XRCC1-deficient cells, a same MNNG treatment caused ATP and NAD depletion, resulting in necrotic cell death without AIF translocation and nuclear shrinkage. Efficient progression of both DNA repair and apoptosis are essential for genomic integrity. The results of present study demonstrate, that the interactions between PARG, PARP-1 and XRCC1 are important for the regulation of both processes. Advisors/Committee Members: n (gender), PD Dr. Shiao Li Oei (firstReferee), Prof. Dr. Petra Knaus (furtherReferee).

Subjects/Keywords: poly (ADP-ribose); PARG; XRCC1; AIF; 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keil, C. (2006). Control of cell death by interactions between proteins involved in poly(ADP- ribose) metabolism. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Keil, Claudia. “Control of cell death by interactions between proteins involved in poly(ADP- ribose) metabolism.” 2006. Thesis, Freie Universität Berlin. Accessed January 22, 2021. http://dx.doi.org/10.17169/refubium-10846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Keil, Claudia. “Control of cell death by interactions between proteins involved in poly(ADP- ribose) metabolism.” 2006. Web. 22 Jan 2021.

Vancouver:

Keil C. Control of cell death by interactions between proteins involved in poly(ADP- ribose) metabolism. [Internet] [Thesis]. Freie Universität Berlin; 2006. [cited 2021 Jan 22]. Available from: http://dx.doi.org/10.17169/refubium-10846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Keil C. Control of cell death by interactions between proteins involved in poly(ADP- ribose) metabolism. [Thesis]. Freie Universität Berlin; 2006. Available from: http://dx.doi.org/10.17169/refubium-10846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Marklund, Sandra. Feasibility Study of Phase Measurements of the Arterial Input Function in Dynamic Contrast Enhanced MRI.

Degree: Radiation Physics, 2009, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-23226

► Acquired data from dynamic contrast enhanced MRI measurements can be used to non-invasively assess tumour vascular characteristics through pharmacokinetic modelling. The modelling requires… (more)

Subjects/Keywords: AIF; Arterial Input Function; DCE-MRI; Dynamic Contrast Enhanced MRI; MRI; Gd; Gadolinium; Phase measurement; Phase; Radiological physics; Radiofysik

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marklund, S. (2009). Feasibility Study of Phase Measurements of the Arterial Input Function in Dynamic Contrast Enhanced MRI. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-23226

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marklund, Sandra. “Feasibility Study of Phase Measurements of the Arterial Input Function in Dynamic Contrast Enhanced MRI.” 2009. Thesis, Umeå University. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-23226.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marklund, Sandra. “Feasibility Study of Phase Measurements of the Arterial Input Function in Dynamic Contrast Enhanced MRI.” 2009. Web. 22 Jan 2021.

Vancouver:

Marklund S. Feasibility Study of Phase Measurements of the Arterial Input Function in Dynamic Contrast Enhanced MRI. [Internet] [Thesis]. Umeå University; 2009. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-23226.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marklund S. Feasibility Study of Phase Measurements of the Arterial Input Function in Dynamic Contrast Enhanced MRI. [Thesis]. Umeå University; 2009. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-23226

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

24. Nodin, Christina. Astrocytic communication and cell death during metabolic depression and oxidative stress.

Degree: 2008, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/9868

► Stroke is a major cause of death and adult disability in the western world. Most often, stroke is caused by the occlusion of a brain… (more)

▼ Stroke is a major cause of death and adult disability in the western world. Most often, stroke is caused by the occlusion of a brain artery. Within the perfusion territory of the occluded vessel, various degrees of necrotic and delayed programmed cell death will occur if the occlusion persists, leading to expanding tissue damage. Astrocytes are the most numerous cells in the brain, but the astrocytic response to ischemic conditions and the extent to which these cells can recover after an ischemic insult is not well understood. An increasing amount of evidence indicates that astrocytes are more sensitive to ischemic injury than previously thought. Astrocytic functions are vitally important for neuronal activity during physiological conditions and probably during various pathological situations, including stroke. Astrocytes are highly coupled by intercellular gap junction channels that enable the formation of large cellular networks. These networks provide the basis for several important astrocytic functions including intracellular signalling and transport of molecules and metabolites. In order to investigate astrocytic reactions during metabolic depression we used the glycolytic blocker iodoacetate (IA) in primary astrocyte cultures. This treatment induced a reproducible and concentration-dependent ATP decrease which was associated with a profound increase in the activity of reactive oxygen species (ROS). This suggests that metabolic depression induced oxidative stress. Moreover, programmed cell death was initiated in individual astrocytes or small cell clusters and spread to include large clusters of astrocytes. However, when gap junction communication was inhibited during metabolic depression, programmed cell death was initiated in individual cells but no expansion into large cell clusters was observed. This suggests that gap junction permeable substances contribute to the spreading of cell death in astrocytes. The observed programmed cell death involved translocation of apoptosis inducing factor from the mitochondria to the nucleus. Similar results were observed in a model of oxidative stress using 3-morpholinosyndomine (SIN-1), a compound known to produce equimolar amounts of superoxide and nitric oxide which react to form peroxynitrite. Caspase-activation was not observed in astrocytes exposed to metabolic depression or oxidative stress. Astrocytes and several other cell types express endogenous antioxidant systems. The expression of many of the enzymes involved in this cellular defense is regulated by the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). The potential protective effect of the Nrf2 system in astrocytes was investigated by using the Nrf2-activating phytochemicals sulforaphane (naturally occurring in broccoli) or curcumin (from turmeric), or the commonly used food additive tert-butylhydroquinone. Exposing the astrocytes to these substances before adding IA or SIN-1, prevented the oxidative stress, enabled the astrocytes to maintain their ATP levels and efficiently…

Subjects/Keywords: astrocyte; gap junction; ATP; ROS; oxidative stress; Annexin V; AIF; programmed cell death; Nrf2; scavenger; iodoacetate; SIN-1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nodin, C. (2008). Astrocytic communication and cell death during metabolic depression and oxidative stress. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/9868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nodin, Christina. “Astrocytic communication and cell death during metabolic depression and oxidative stress.” 2008. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 22, 2021. http://hdl.handle.net/2077/9868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nodin, Christina. “Astrocytic communication and cell death during metabolic depression and oxidative stress.” 2008. Web. 22 Jan 2021.

Vancouver:

Nodin C. Astrocytic communication and cell death during metabolic depression and oxidative stress. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2008. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2077/9868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nodin C. Astrocytic communication and cell death during metabolic depression and oxidative stress. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2008. Available from: http://hdl.handle.net/2077/9868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Herngren, Ted; Strandberg, Hanna; Söderlund, Mattias; Ekerlund, Kristofer. Webb-tv för Mjällby AIF.

Degree: Humanities and Planning, 2008, School of Technoculture

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-1270

►

Vi valde som kandidatarbete att göra en webbapplikation för att hantera webb-tv-lösningar för att vi ville samla kompetenserna inom programmet medieteknik där videoproduktion, flashproduktion,… (more)

Subjects/Keywords: Medieteknik; Webb-tv; Video; Plattform; Tv; Film; Flash; Mjällby AIF; H264; Motion Graphics; Webbdesign

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herngren, Ted; Strandberg, Hanna; Söderlund, Mattias; Ekerlund, K. (2008). Webb-tv för Mjällby AIF. (Thesis). School of Technoculture. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:bth-1270

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Herngren, Ted; Strandberg, Hanna; Söderlund, Mattias; Ekerlund, Kristofer. “Webb-tv för Mjällby AIF.” 2008. Thesis, School of Technoculture. Accessed January 22, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-1270.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Herngren, Ted; Strandberg, Hanna; Söderlund, Mattias; Ekerlund, Kristofer. “Webb-tv för Mjällby AIF.” 2008. Web. 22 Jan 2021.

Vancouver:

Herngren, Ted; Strandberg, Hanna; Söderlund, Mattias; Ekerlund K. Webb-tv för Mjällby AIF. [Internet] [Thesis]. School of Technoculture; 2008. [cited 2021 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-1270.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Herngren, Ted; Strandberg, Hanna; Söderlund, Mattias; Ekerlund K. Webb-tv för Mjällby AIF. [Thesis]. School of Technoculture; 2008. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-1270

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Victoria

26. Mosayyebpour, Saeed. Robust Single-Channel Speech Enhancement and Speaker Localization in Adverse Environments.

Degree: Department of Electrical and Computer Engineering, 2014, University of Victoria

URL: http://hdl.handle.net/1828/5342

► In speech communication systems such as voice-controlled systems, hands-free mobile telephones and hearing aids, the received signals are degraded by room reverberation and background noise.… (more)

▼ In speech communication systems such as voice-controlled systems, hands-free mobile telephones and hearing aids, the received signals are degraded by room reverberation and background noise. This degradation can reduce the perceived quality and intelligibility of the speech, and decrease the performance of speech enhancement and source localization. These problems are difficult to solve due to the colored and nonstationary nature of the speech signals, and features of the Room Impulse Response (RIR) such as its long duration and non-minimum phase. In this dissertation, we focus on two topics of speech enhancement and speaker localization in noisy reverberant environments. A two-stage speech enhancement method is presented to suppress both early and late reverberation in noisy speech using only one microphone. It is shown that this method works well even in highly reverberant rooms. Experiments under different acoustic conditions confirm that the proposed blind method is superior in terms of reducing early and late reverberation effects and noise compared to other well known single-microphone techniques in the literature. Time Difference Of Arrival (TDOA)-based methods usually provide the most accurate source localization in adverse conditions. The key issue for these methods is to accurately estimate the TDOA using the smallest number of microphones. Two robust Time Delay Estimation (TDE) methods are proposed which use the information from only two microphones. One method is based on adaptive inverse filtering which provides superior performance even in highly reverberant and moderately noisy conditions. It also has negligible failure estimation which makes it a reliable method in realistic environments. This method has high computational complexity due to the estimation in the first stage for the first microphone. As a result, it can not be applied in time-varying environments and real-time applications. Our second method improves this problem by introducing two effective preprocessing stages for the conventional Cross Correlation (CC)-based methods. The results obtained in different noisy reverberant conditions including a real and time-varying environment demonstrate that the proposed methods are superior compared to the conventional TDE methods. Advisors/Committee Members: Gulliver, T. Aaron (supervisor), Esmaeili, Morteza (supervisor).

Subjects/Keywords: skewness; early and late reverberation; noise; single-microphone; spectral subtraction; Time Delay Estimation (TDE); Time Difference of Arrival (TDOA); Adaptive Inverse Filtering (AIF); Generalized Cross-Correlation (GCC); room impulse response (RIR)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mosayyebpour, S. (2014). Robust Single-Channel Speech Enhancement and Speaker Localization in Adverse Environments. (Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/5342

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mosayyebpour, Saeed. “Robust Single-Channel Speech Enhancement and Speaker Localization in Adverse Environments.” 2014. Thesis, University of Victoria. Accessed January 22, 2021. http://hdl.handle.net/1828/5342.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mosayyebpour, Saeed. “Robust Single-Channel Speech Enhancement and Speaker Localization in Adverse Environments.” 2014. Web. 22 Jan 2021.

Vancouver:

Mosayyebpour S. Robust Single-Channel Speech Enhancement and Speaker Localization in Adverse Environments. [Internet] [Thesis]. University of Victoria; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1828/5342.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mosayyebpour S. Robust Single-Channel Speech Enhancement and Speaker Localization in Adverse Environments. [Thesis]. University of Victoria; 2014. Available from: http://hdl.handle.net/1828/5342

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

27. Heeres, James T. High-throughput detection of protein???protein and protein???DNA interactions via photonic crystal biosensors: applications to apoptosis inducing factor.

Degree: PhD, 0318, 2010, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/17028

► High-throughput screening (HTS) has played an integral role in the discovery of lead molecules that eventually are transformed into the therapies of tomorrow. Contributing towards… (more)

Subjects/Keywords: Photonic Crystals; Apoptosis Inducing Factor; apoptosis inducing factor (AIF); Protein-DNA Interactions; Protein-Protein Interactions

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APA (6^th Edition):

Heeres, J. T. (2010). High-throughput detection of protein???protein and protein???DNA interactions via photonic crystal biosensors: applications to apoptosis inducing factor. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/17028

Chicago Manual of Style (16^th Edition):

Heeres, James T. “High-throughput detection of protein???protein and protein???DNA interactions via photonic crystal biosensors: applications to apoptosis inducing factor.” 2010. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 22, 2021. http://hdl.handle.net/2142/17028.

MLA Handbook (7^th Edition):

Heeres, James T. “High-throughput detection of protein???protein and protein???DNA interactions via photonic crystal biosensors: applications to apoptosis inducing factor.” 2010. Web. 22 Jan 2021.

Vancouver:

Heeres JT. High-throughput detection of protein???protein and protein???DNA interactions via photonic crystal biosensors: applications to apoptosis inducing factor. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2010. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2142/17028.

Council of Science Editors:

Heeres JT. High-throughput detection of protein???protein and protein???DNA interactions via photonic crystal biosensors: applications to apoptosis inducing factor. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2010. Available from: http://hdl.handle.net/2142/17028

Brno University of Technology

28. Holeček, Tomáš. Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/38138

► Perfusion magnetic resonance imaging is modern diagnostic method used mainly in oncology. In this method, contrast agent is injected to the subject and then is… (more)

Subjects/Keywords: Magnetická rezonance; DCE-MRI; perfusní analýza; AIF; TRF; multikanálová slepá dekonvoluce; škálování; Magnetic resonance imaging; dynamic contrast enhanced magnetic resonance imaging; perfusion analysis; arterial input function; impulse response function; multichannel blind deconvolution; scaling

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APA (6^th Edition):

Holeček, T. (2019). Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/38138

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Holeček, Tomáš. “Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI.” 2019. Thesis, Brno University of Technology. Accessed January 22, 2021. http://hdl.handle.net/11012/38138.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Holeček, Tomáš. “Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI.” 2019. Web. 22 Jan 2021.

Vancouver:

Holeček T. Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11012/38138.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Holeček T. Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/38138

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

29. Holeček, Tomáš. Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI.

Degree: 2014, Brno University of Technology

URL: http://hdl.handle.net/11012/31559

► Perfusion magnetic resonance imaging is modern diagnostic method used mainly in oncology. In this method, contrast agent is injected to the subject and then is… (more)

Subjects/Keywords: Magnetická rezonance; DCE-MRI; perfusní analýza; AIF; TRF; multikanálová slepá dekonvoluce; škálování; Magnetic resonance imaging; dynamic contrast enhanced magnetic resonance imaging; perfusion analysis; arterial input function; impulse response function; multichannel blind deconvolution; scaling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Holeček, T. (2014). Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/31559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Holeček, Tomáš. “Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI.” 2014. Thesis, Brno University of Technology. Accessed January 22, 2021. http://hdl.handle.net/11012/31559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Holeček, Tomáš. “Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI.” 2014. Web. 22 Jan 2021.

Vancouver:

Holeček T. Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI. [Internet] [Thesis]. Brno University of Technology; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11012/31559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Holeček T. Škálování arteriální vstupní funkce v DCE-MRI: Scaling of arterial input function in DCE-MRI. [Thesis]. Brno University of Technology; 2014. Available from: http://hdl.handle.net/11012/31559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

30. Faraday, Bruce Douglas. Half the battle : the administration and higher organisation of the AIF 1914-1918.

Degree: History, 1997, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/38693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:3217/SOURCE01?view=true

► Administration of armies has been sadly neglected in historical studies but the ability of the AIF to develop an efficient system of administration and to… (more)

Subjects/Keywords: World War; 1914-1918; Armed Forces; Australian Imperial Force; AIF; Canadian Expeditionary Force; CEF; military administration; army; war supply; equipment; equipping; demobilisation; demobilise; discipline; medical service; organisation; organization; management

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Faraday, B. D. (1997). Half the battle : the administration and higher organisation of the AIF 1914-1918. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/38693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:3217/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Faraday, Bruce Douglas. “Half the battle : the administration and higher organisation of the AIF 1914-1918.” 1997. Doctoral Dissertation, University of New South Wales. Accessed January 22, 2021. http://handle.unsw.edu.au/1959.4/38693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:3217/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Faraday, Bruce Douglas. “Half the battle : the administration and higher organisation of the AIF 1914-1918.” 1997. Web. 22 Jan 2021.

Vancouver:

Faraday BD. Half the battle : the administration and higher organisation of the AIF 1914-1918. [Internet] [Doctoral dissertation]. University of New South Wales; 1997. [cited 2021 Jan 22]. Available from: http://handle.unsw.edu.au/1959.4/38693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:3217/SOURCE01?view=true.

Council of Science Editors:

Faraday BD. Half the battle : the administration and higher organisation of the AIF 1914-1918. [Doctoral Dissertation]. University of New South Wales; 1997. Available from: http://handle.unsw.edu.au/1959.4/38693 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:3217/SOURCE01?view=true

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