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You searched for subject:(ABC transporter A1). Showing records 1 – 2 of 2 total matches.

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Wake Forest University

1. Liu, Mingxia. ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM.

Degree: 2013, Wake Forest University

Apolipoprotein M (ApoM) and ABCA1 are both expressed in hepatocytes, but their impact on lipid metabolism remains poorly defined. ApoM binds to plasma HDL via its retained signal peptide and transports sphingosine 1–phosphate (S1P). We found that liver–specific apoM transgenic mice had larger plasma HDLs enriched with apoM, cholesteryl ester, lecithin:cholesterol acyltransferase and S1P, but not enhanced macrophage reverse cholesterol transport compared to wild type mice. Hepatocytes from transgenic mice generated larger nascent HDLs and stimulated sphingolipid synthesis and S1P secretion. Inhibition of ceramide synthase significantly increased cellular but not media S1P in apoM Tg hepatocytes, suggesting that apoM is rate limiting for S1P secretion. Overexpression of apoMQ22A, a mutant form of apoM with a cleavable signal peptide, in HEK293 cells and in mice did not stimulate larger nascent or mature HDL formation, but its overexpression in hepatocytes had faster secretion of apoMQ22A and mobilization of cellular S1P than apoMWT. We conclude that hepatic apoM overexpression facilitates the generation of large, apoM/S1P–enriched plasma HDLs and that this activity is dependent on its signal peptide retention.

Subjects/Keywords: ABC transporter A1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Liu, M. (2013). ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/39029

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Liu, Mingxia. “ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM.” 2013. Thesis, Wake Forest University. Accessed April 12, 2021. http://hdl.handle.net/10339/39029.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Liu, Mingxia. “ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM.” 2013. Web. 12 Apr 2021.

Vancouver:

Liu M. ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/10339/39029.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu M. ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/39029

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Zhao, Ying. Reverse cholesterol transport: a potential therapeutic target for atherosclerosis.

Degree: 2011, Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Faculty of Science, Leiden University

Atherosclerosis is the major cause of death in the Western society due to the development of acute clinical events such as myocardial infarction and cerebral stroke. Currently, lowering plasma LDL cholesterol (LDL-C) levels using statins, inhibitors of de-novo cholesterol synthesis, is the main therapeutic strategy to prevent the progression of atherosclerosis. The remaining high incidence of cardiovascular disease indicates a clear need for new therapies. Numerous epidemiological studies have established HDL cholesterol (HDL-C) levels as an inverse predictor for atherosclerosis. HDL has important anti-oxidative and anti-inflammatory properties. The most important atheroprotective function of HDL is, however, facilitation of reverse cholesterol transport (RCT), a process in which HDL removes excess cholesterol from peripheral tissues and subsequently delivers it to the liver for biliary excretion. In this thesis, the importance of RCT for prevention of atherosclerosis and the potential of RCT augmentation for the treatment of atherosclerosis were evaluated.

Subjects/Keywords: Reverse cholesterol transport; ABC-transporter A1; Scavenger receptor class B type I; Reverse cholesterol transport; ABC-transporter A1; Scavenger receptor class B type I

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Zhao, Y. (2011). Reverse cholesterol transport: a potential therapeutic target for atherosclerosis. (Doctoral Dissertation). Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/18008

Chicago Manual of Style (16th Edition):

Zhao, Ying. “Reverse cholesterol transport: a potential therapeutic target for atherosclerosis.” 2011. Doctoral Dissertation, Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed April 12, 2021. http://hdl.handle.net/1887/18008.

MLA Handbook (7th Edition):

Zhao, Ying. “Reverse cholesterol transport: a potential therapeutic target for atherosclerosis.” 2011. Web. 12 Apr 2021.

Vancouver:

Zhao Y. Reverse cholesterol transport: a potential therapeutic target for atherosclerosis. [Internet] [Doctoral dissertation]. Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2011. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/1887/18008.

Council of Science Editors:

Zhao Y. Reverse cholesterol transport: a potential therapeutic target for atherosclerosis. [Doctoral Dissertation]. Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2011. Available from: http://hdl.handle.net/1887/18008

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