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1. Melo, Gabriela Muniz de Albuquerque. Avaliação da atividade antinociceptiva e antiinflamatória de dois diterpenos e extratos da casca do caule de Xylopia langsdorffiana (Annonaceae).

Degree: 2009, Universidade Federal de Alagoas

This study describes the results of the study of the antinociceptive and antiinflammatory activity of ethanolic extract (EEt) and chloroform (ECl) from Xylopia langsdorffiana St-Hil & Tul and the diterpenes acid labda-8(17),12E,14-trien-18-oic (XL) and acid ent-7α-acetoxytrachyloban-18-oic (XLC) of these isolates, respectively. Substances (XL and XLC, 300 μmol/Kg, i.p) and extracts (EEt and ECl, 100 mg/Kg, i.p.) inhibited significantly the number of abdominal writhes when compared to control. To evaluate the power and effectiveness of the substances XL, XLC and dipyrone (300 μmol/Kg 100 μmol/Kg , 30 μmol/Kg, 10 μmol/Kg e 1 μmol/Kg, i.p.) was calculated, the dose that inhibits 50 percent of the response (DI50). The DI50 of XL was 42,8 μmol/Kg, that of XLC was 17,41 μmol/Kg, dipyrone already submitted a DI50 of 14,68 μmol/Kg. Comparing the DI50 of XL, XLC and dipyrone may be observed that the XLC had a power greater than the XL, and the value of DI50 nearest the dipyrone. The xlc also showed that the efficiency XL In the test of nociception induced by formalin, the substances XL and XLC (100 μmol/Kg, i.p.) and extracts (EEt e ECl, 100 mg/Kg, i.p.) induced significant inhibition of licking time in both the neurogenic phase (41,52%, 33,69%, 40,12%, 79,4%, of inhibition, respectively), as in the inflammatory phase (44,1%, 63,9%, 62,7% e 83,7%, of inhibition, respectively) compared to the control. Substances (XL e XLC, 100 μmol/Kg, i.p) and the extracts (EEt e ECl, 100 mg/Kg, i.p.) were not active in hot plate test, which aims to assess the central antinociceptive activity. Using the test of ear edema induced by capsaicin, it was possible to determine that there was no statistically significant difference in percentage of inhibition of edema between the indomethacin (100 μmol/Kg, i.p.), used in standard drug test, and diterpenes XL and XLC in different concentrations (300, 100, 30, 1 e 0,3 μmol/Kg), (XLC trachylobano except at a concentration of 0,3 μmol/Kg). XL and XLC (100 μmol/Kg, i.p.), and the extract (EEt e ECl, 100 mg/Kg, i.p.), reduced the cell migration induced by Zymosan A, a statistically significant way. These substances and extracts induced a reduction in cell migration of 36,40%, 49,51%, 42,51%, 51,97%, respectively. XLC was not efficient to inhibit the progression of rheumatoid arthritis. In the model of acute toxicity, XL and XLC,were not toxic, while the opposite occurred for the administration of the extracts. Our results we infer that EEt and ECl from Xylopia langsdorffiana as its isolated XLC and XL have antinociceptive and antiinflammatory activity, being described by the first for these substances and extracts.

Fundação de Amparo a Pesquisa do Estado de Alagoas

Este trabalho descreve os resultados do estudo da atividade antinociceptiva e antiinflamatória dos extratos etanólico (EEt) e clorofórmico (ECl) obtidos da casca do caule de Xylopia langsdorffiana St-Hil & Tul, bem como dos diterpenos ácido labda-…

Advisors/Committee Members: Moreira, Magna Suzana Alexandre, CPF:75998947487, ALEXANDRE-MOREIRA M. S, Kanashiro, Célia Akemi, CPF:04094927875, KANASHIRO, C. A., Barreto, Emiliano de Oliveira, CPF:04552293761, Barreto, E. O., Ribeiro, êurica Adélia Nogueira, CPF:02767997478, RIBEIRO, Ê. A. N..

Subjects/Keywords: Xylopia langsdorffiana; Atividade antinociceptiva; Atividade antiinflamatória; Extrato etanólico; Extrato clorofórmico; Ácido labda-8(17),12E,14-trien-18-óico; Ácido ent-7α; -acetoxitrachiloban-18-óico; Xylopia langsdorffiana; Antinociceptive activity; Aantiinflammatory activity; Eetanolic extract; Cloroform extract; Acid labda-8(17),12E,14-trien-18-óico; Acid ent-7α; -acetoxitrachiloban-18-óico; CNPQ::CIENCIAS DA SAUDE

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Melo, G. M. d. A. (2009). Avaliação da atividade antinociceptiva e antiinflamatória de dois diterpenos e extratos da casca do caule de Xylopia langsdorffiana (Annonaceae). (Masters Thesis). Universidade Federal de Alagoas. Retrieved from http://www.repositorio.ufal.br/handle/riufal/925

Chicago Manual of Style (16th Edition):

Melo, Gabriela Muniz de Albuquerque. “Avaliação da atividade antinociceptiva e antiinflamatória de dois diterpenos e extratos da casca do caule de Xylopia langsdorffiana (Annonaceae).” 2009. Masters Thesis, Universidade Federal de Alagoas. Accessed October 25, 2020. http://www.repositorio.ufal.br/handle/riufal/925.

MLA Handbook (7th Edition):

Melo, Gabriela Muniz de Albuquerque. “Avaliação da atividade antinociceptiva e antiinflamatória de dois diterpenos e extratos da casca do caule de Xylopia langsdorffiana (Annonaceae).” 2009. Web. 25 Oct 2020.

Vancouver:

Melo GMdA. Avaliação da atividade antinociceptiva e antiinflamatória de dois diterpenos e extratos da casca do caule de Xylopia langsdorffiana (Annonaceae). [Internet] [Masters thesis]. Universidade Federal de Alagoas; 2009. [cited 2020 Oct 25]. Available from: http://www.repositorio.ufal.br/handle/riufal/925.

Council of Science Editors:

Melo GMdA. Avaliação da atividade antinociceptiva e antiinflamatória de dois diterpenos e extratos da casca do caule de Xylopia langsdorffiana (Annonaceae). [Masters Thesis]. Universidade Federal de Alagoas; 2009. Available from: http://www.repositorio.ufal.br/handle/riufal/925

2. Cheng, Xiwen. The Functional Study of Transcriptional Corepressor G-Protein Suppressor 2 (GPS2) and Tumor Suppressor Promyelocytic Leukemia (PML).

Degree: PhD, Biochemistry, 2010, Case Western Reserve University School of Graduate Studies

We have identified G-protein pathway suppressor 2 (GPS2) as an integral component of the silencing mediator of retinoid acid and thyroid hormone receptor (SMRT) corepressor complex. Functional studies revealed that GPS2 is functionally important for estrogen receptor alpha (ERα)-mediated transcriptional regulation, and that GPS2/SMRT complex is important for maintaining normal proliferation of MCF-7 breast cancer cells. The promyelocytic leukemia protein (PML) is a well-known tumor suppressor, but its role in endothelial cells (ECs) is largely unknown, despite its high expression in endothelium and inflamed tissues. We have demonstrated that PML negatively regulates angiogenesis and cell migration, reconciling with upstream signal transducer and activator of transcription 1 (STAT1) and downstream integrin β1 (ITGB1), thus identifying a novel pathway in which PML mediates the TNFα/IFNα signaling in ECs. Finally, we carried out microarray analysis in ECs and identified the differentially expressed genes when PML is knocked down and/or when cells are treated with TNFα. We further characterized the functional ontology of these gene lists and identified groups of interesting genes that warrant future study. Advisors/Committee Members: Kao, Hung-Ying (Advisor), Samols, David (Committee Chair).

Subjects/Keywords: Biochemistry; Bioinformatics; Cellular Biology; Molecular Biology; GPS2; SMRT; Estrogen Receptor alpha; ER&945; pS2; MCF-7; ChIP; proliferation; tamoxifen resistance; PML; angiogenesis; migration; HUVEC; HMVEC; cytokine; TNF&945; IFN&945; ITGB1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Cheng, X. (2010). The Functional Study of Transcriptional Corepressor G-Protein Suppressor 2 (GPS2) and Tumor Suppressor Promyelocytic Leukemia (PML). (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1277741995

Chicago Manual of Style (16th Edition):

Cheng, Xiwen. “The Functional Study of Transcriptional Corepressor G-Protein Suppressor 2 (GPS2) and Tumor Suppressor Promyelocytic Leukemia (PML).” 2010. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed October 25, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1277741995.

MLA Handbook (7th Edition):

Cheng, Xiwen. “The Functional Study of Transcriptional Corepressor G-Protein Suppressor 2 (GPS2) and Tumor Suppressor Promyelocytic Leukemia (PML).” 2010. Web. 25 Oct 2020.

Vancouver:

Cheng X. The Functional Study of Transcriptional Corepressor G-Protein Suppressor 2 (GPS2) and Tumor Suppressor Promyelocytic Leukemia (PML). [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2010. [cited 2020 Oct 25]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1277741995.

Council of Science Editors:

Cheng X. The Functional Study of Transcriptional Corepressor G-Protein Suppressor 2 (GPS2) and Tumor Suppressor Promyelocytic Leukemia (PML). [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1277741995

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