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Universitat Autònoma de Barcelona

1. Miralpeix Rovira, Ester. Valor predictiu de les cèl·lules NK en l’evolució de la neoplàsia intraepitelial cervical grau 2.

Degree: Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva, 2016, Universitat Autònoma de Barcelona

Cervical Intraepithelial Neoplasia (CIN) is a precursor lesion of cervical cancer with a well-known natural history that starts from an infection caused by the human papillomavirus (HPV). There are multiple cofactors that can modulate the capacity of spontaneous CIN regression or progression. Unfortunately, there are no predictive factors regarding the evolution of CIN2 that could be used clinically to individualize the appropriate treatment and follow-up. The CIN2 is an intermediate state between CIN1 and CIN3 with spotaneous regression rates of 40-60% and progression rate of 10-20% described in the literature. Althought conization is the usual management of CIN2 lesions, current American (ASCCP) and Spanish (SEGO) guidelines propose conservative management in young and selected patients to avoid their over-treatment. NK cells (natural killer cells), involved in the innate immune response, could be related with this capacity of CIN2 to regress spontaneously. In order to identify markers that can predict the CIN2 evolution, aims to study the immune system, specifically Natural Killer cells. NK cells found in peripheral blood have the ability to remove infected or tumor cells wich have lost the expression of major histocompatibility complex class I (MHC I) in pathological conditions, that would prevent the activation of T cells’ immune response. Our hypothesis is that a deterioration of the NK functionality, analysed through a lower percentatge of NK cells receptors expression, could consequently decrease the capacity of CIN2 spontaneously regression. Between December 2011 and October 2013, patients with histological diagnosis of CIN-2 cervical biopsy, older than 18 years old, who agreed to follow up every 4 months for at least 2 years, were prospectively recruited. Unsatisfactory colposcopy and immunosuppressive treatment were considered exclusion criteria. NK cells, serologies (HIV, Herpes 2, HBV, HCV, Chlamydia trachomatis and Lues), previous abnormal cytology, genotyping of high-risk HPV and epidemiological features were reported at baseline in all women included. Total regression was defined as two consecutive negative cytologies and no evidence of colposcopic lesions, partial regression if final biopsy showed CIN1, persistence when biopsy showed CIN2, and progression if a CIN3 biopsy was detected at any time during follow-up. The mean age of 105 patients included was 30.5 years (range, 18-56), 54.3% were smokers and 74.3% were nulliparous. Overall, the rate of spontaneous total regression at 2 years of follow-up was 44%, 21.5% presented partiral regression, 11.8% had persistent disease, while 7.8% progressed. Knowing that CMV infection is associated with redistribution of NK cells receptors, particularly NKG2C expression, this study showed that this change could help predict the evolution of CIN2 lesions. As well as, chlamydia immunity [OR: 19.1 (95% CI 1.9 to 189.7)], VPH16 infection [OR 5.9 (95% CI 1.7 to 14.6)] and previous HSIL cytology [OR 4.8 (95% CI 1.7 to 13.7)], were statistically associated… Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Carreras Collado, Ramon (director), Mancebo Moreno, Gemma (director), Alameda Quitllet, Francesc (director), true (authorsendemail).

Subjects/Keywords: Neoplasia intraepitelial cervical grau 2; Neoplasia intraepitelial cervical grado 2; Cervial intraepithelial neoplasia grade 2; Cèl·lules NK; Células NK; NK cells; Maneig conservador; Manejo conservador; Expecant management; Ciències de la Salut; 618

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Miralpeix Rovira, E. (2016). Valor predictiu de les cèl·lules NK en l’evolució de la neoplàsia intraepitelial cervical grau 2. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/393970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Miralpeix Rovira, Ester. “Valor predictiu de les cèl·lules NK en l’evolució de la neoplàsia intraepitelial cervical grau 2.” 2016. Thesis, Universitat Autònoma de Barcelona. Accessed November 27, 2020. http://hdl.handle.net/10803/393970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Miralpeix Rovira, Ester. “Valor predictiu de les cèl·lules NK en l’evolució de la neoplàsia intraepitelial cervical grau 2.” 2016. Web. 27 Nov 2020.

Vancouver:

Miralpeix Rovira E. Valor predictiu de les cèl·lules NK en l’evolució de la neoplàsia intraepitelial cervical grau 2. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2016. [cited 2020 Nov 27]. Available from: http://hdl.handle.net/10803/393970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Miralpeix Rovira E. Valor predictiu de les cèl·lules NK en l’evolució de la neoplàsia intraepitelial cervical grau 2. [Thesis]. Universitat Autònoma de Barcelona; 2016. Available from: http://hdl.handle.net/10803/393970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Schalck, Claudine. Le travail des soignants dédiés à la vie face à la mort périnatale : sages-femmes et gynécologues-obstétricien(ne)s : The work of the caregivers dedicaced to life facing perinatal death : midwives and obstetricians.

Degree: Docteur es, Psychologie, psychologie clinique, psychologie sociale. Psychologie, 2017, Paris, CNAM

Grâce à des entretiens non directifs réalisés auprès de 16 sages-femmes et 16 obstétricien(ne)s, cette recherche tente de cerner l’impact que la mort périnatale a sur eux et sur leur travail, au-delà de celui qu’elle a sur les parents avec le deuil périnatal. Face à des progrès médicaux sans précédent, la société, les parents et les soignants eux-mêmes s’attendent peu à la survenue de la mort dans la naissance. Interruption médicale de grossesse ou mort périnatale inattendue confrontent cependant ces soignants à des épreuves au travail susceptibles d’avoir sur eux des répercussions majeures selon le contexte et l’âge de la grossesse. Elles donnent lieu à des déficits de la reconnaissance, qu’elle soit sociale, professionnelle ou personnelle. Leur restauration nécessite le recours actif à l’intersubjectivité engagée auprès des pairs comme auprès des parents afin que les soignants puissent continuer leur travail et y rester.

Through 32 open-ended interviews with midwives and obstetricians, this work attempts to identify, beyond parental mourning, the impact of perinatal death on childbirth professionals and their work. Unprecedented medical advances result in a relative absence of expectation of death in birth for the society, medical professionals and for the parents. Medically motivated induced termination or unexpected perinatal death, however, confronts caregivers at work with an ordeal which can have major repercussions depending on the context and the term of the pregnancy involved. These events cause deficits in social, professional and personal recognition in these caregivers. To be restored, symbolic processing is necessary for all concerned through the implication of subjectivity at work with peers and parents in order for these caregivers to be able to continue to work.

Advisors/Committee Members: Lhuilier, Dominique (thesis director).

Subjects/Keywords: Travail; Soignants; Mort périnatale; Sages-Femmes; Obstétriciens; Impact; Blessures de la reconnaissance; Subjectivité au travail; Work; Caregivers; Perinatal death; Midwives; Obstetricians; Impact; Recognition wounds; Subjectivity at work; 618.392 001 9; 155.937 088 618 2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Schalck, C. (2017). Le travail des soignants dédiés à la vie face à la mort périnatale : sages-femmes et gynécologues-obstétricien(ne)s : The work of the caregivers dedicaced to life facing perinatal death : midwives and obstetricians. (Doctoral Dissertation). Paris, CNAM. Retrieved from http://www.theses.fr/2017CNAM1155

Chicago Manual of Style (16th Edition):

Schalck, Claudine. “Le travail des soignants dédiés à la vie face à la mort périnatale : sages-femmes et gynécologues-obstétricien(ne)s : The work of the caregivers dedicaced to life facing perinatal death : midwives and obstetricians.” 2017. Doctoral Dissertation, Paris, CNAM. Accessed November 27, 2020. http://www.theses.fr/2017CNAM1155.

MLA Handbook (7th Edition):

Schalck, Claudine. “Le travail des soignants dédiés à la vie face à la mort périnatale : sages-femmes et gynécologues-obstétricien(ne)s : The work of the caregivers dedicaced to life facing perinatal death : midwives and obstetricians.” 2017. Web. 27 Nov 2020.

Vancouver:

Schalck C. Le travail des soignants dédiés à la vie face à la mort périnatale : sages-femmes et gynécologues-obstétricien(ne)s : The work of the caregivers dedicaced to life facing perinatal death : midwives and obstetricians. [Internet] [Doctoral dissertation]. Paris, CNAM; 2017. [cited 2020 Nov 27]. Available from: http://www.theses.fr/2017CNAM1155.

Council of Science Editors:

Schalck C. Le travail des soignants dédiés à la vie face à la mort périnatale : sages-femmes et gynécologues-obstétricien(ne)s : The work of the caregivers dedicaced to life facing perinatal death : midwives and obstetricians. [Doctoral Dissertation]. Paris, CNAM; 2017. Available from: http://www.theses.fr/2017CNAM1155


Freie Universität Berlin

3. Keckeis, Susanne. Investigation of Ca2+-activated ion channels in epithelia of the eye.

Degree: 2018, Freie Universität Berlin

A regulated transport of ions and water is essential for ocular structures on which vision directly depends: the crystalline lens and the retinal pigment epithelium (RPE). In the lens, an ion imbalance results in the loss of transparency caused by an increased cation permeability of epithelial cell membranes, which might be a result of the activation of Ca2+-activated cation channels. Thus, in the first part of this thesis, functional expression and molecular identity of such channels were investigated. The Ca2+-ionophore ionomycin activated a non-selective cation channel in both primary lens epithelial and HLE B-3 cells. By analysis of cation channel expression pattern, biophysical properties, and pharmacological profiling, the channel was identified as TRPM2. Cataractogenous factors increased the activity of TRPM2, which was localized in cytoplasm membranes of lens epithelial cells: H2O2 activated TRPM2; transforming growth factor (TGF)-β2 increased the expression and current of TRPM2. Thus, TRPM2 is functionally expressed in human lens epithelial cells, where it strongly participates in the conductance and the potential of the cell membrane. Due to its activation by cataractogenous factors, TRPM2 might be involved in lens opacification. The second part of the work dealt with the electrophysiological behavior of the RPE. By precise control of the ion and water transport, the RPE ensures integrity of the retina as neuronal component of the eye. The basolateral localized Ca2+-activated Cl- channel (CaCC) plays an important role. This part of the thesis addressed the question if the CaCC is anoctamin-2 (Ano2), which resembles the CaCC in the RPE. Whole-cell measurements and different Cl- channel blockers confirmed functional expression of a CaCC in ARPE-19 cells and primary murine RPE cells, where ATP served as physiological stimulus in order to increase intracellular Ca2+. Down-regulation of Ano2 expression by siRNA approaches decreased the Cl- current. This study demonstrates that Ano2 participates significantly to the Cl- conductance of the RPE. In cooperation with Frederik Fried and Dr. Nadine Reichhart, regulation of the Ca2+-conducting ion channel TRPV2 in ARPE-19 cells was examined. TRPV2 currents were induced by heating the bath solution to 45 °C. By a phosphatidylinositol-3-kinase (PI3K)-dependent increase of surface expression, cannabidiol as well as insulin-like growth factor (IGF) 1 led to a current increase that was significantly larger than that of heating alone. Thus, enhancement of TRPV2 activity by exogenous agonists may increase intracellular Ca2+ concentration and possibly activate Ano2. In summary, these studies show that a Ca2+-activated TRP channel is functionally expressed in the lens, and Ano2 is functionally expressed in the RPE. In addition, it has been found that the activity of both might be modified by different, possibly pathological, factors. These results may serve as the basis for further studies, how far specifically the activity of both channels is involved in the physiological… Advisors/Committee Members: [email protected] (contact), w (gender), Prof. Dr. Olaf Strauß (firstReferee), Pof. Dr. Ursula Koch (furtherReferee).

Subjects/Keywords: ocular epithelia; Ca2+-activated ion channels; lens; TRPM2; anoctamins; anoctamin-2; TMEM16B; retinal pigment epithelium; RPE; 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::571 Physiologie und verwandte Themen; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::612 Humanphysiologie; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::611 Menschliche Anatomie, Zytologie, Histologie; 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::618 Experimentelle Medizin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Keckeis, S. (2018). Investigation of Ca2+-activated ion channels in epithelia of the eye. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Keckeis, Susanne. “Investigation of Ca2+-activated ion channels in epithelia of the eye.” 2018. Thesis, Freie Universität Berlin. Accessed November 27, 2020. http://dx.doi.org/10.17169/refubium-5286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Keckeis, Susanne. “Investigation of Ca2+-activated ion channels in epithelia of the eye.” 2018. Web. 27 Nov 2020.

Vancouver:

Keckeis S. Investigation of Ca2+-activated ion channels in epithelia of the eye. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2020 Nov 27]. Available from: http://dx.doi.org/10.17169/refubium-5286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Keckeis S. Investigation of Ca2+-activated ion channels in epithelia of the eye. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-5286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.