subject:(600 Technik Medizin angewandte Wissenschaften 630 Landwirtschaft 630 Landwirtschaft und verwandte Bereiche)

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Freie Universität Berlin

1. Roth, Swaantje Juliane. Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen Populationsgebieten.

Degree: 2012, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4766

► Phocines Herpesvirus 1 (PhHV-1) gehört als großes, doppelsträngiges DNA Virus der Familie Herpesviridae, Subfamilie Herpesvirinae, Genus Varicellovirus an. Erstmals isoliert und partiell charakterisiert wurde das… (more)

▼ Phocines Herpesvirus 1 (PhHV-1) gehört als großes, doppelsträngiges DNA Virus der Familie Herpesviridae, Subfamilie Herpesvirinae, Genus Varicellovirus an. Erstmals isoliert und partiell charakterisiert wurde das Virus bei erkrankten jungen Seehunden (Phoca vitulina) in der Nordsee. PhHV-1 ist weltweit verbreitet und Erkankungen sind assoziiert mit hoher Morbidität und Mortalität. Virusisolate von Tieren im Antlantik / in europäischen Gewässern differieren genetisch von Isolaten von Robben aus dem Pazifik und auch postmortale Befunde bei erkrankten Tieren sind unterschiedlicher Ausprägung. Während Pneumonie und hepatische Nekrosen das pathologische Bild in mit europäischen Isolaten infizierten Robben dominieren, sind adrenale Nekrosen ein charakteristischer Hauptbefund in pazifischen Robbenarten. Nur wenige Studien berichten bisher über PhHV-1 Seroprävalenzen in wild lebenden Robben, die meisten davon über Tiere der nördlichen Hemisphäre. Insbesondere bei Tieren in Zoos und Aquarien werden häufig bilaterale Augenerkrankungen unbekannter Ätiologie diagnostiziert. Die Symptomatik ist auch, jedoch seltener, bei wild lebenden Tieren bekannt. Da die Reaktivierung von felinem Herpesvirus 1 (FeHV-1) in Katzen eine sehr ähnliche Symptomatik verursacht, wurde die Hypothese aufgestellt, dass PhHV-1 an der Ätiologie von Augenerkrankungen in Robben beteiligt ist. Ein PhHV-1 spezifischer quantitative-Echtzeit-PCR (qPCR) Assay, basierend auf Alignments bekannter PhHV-1 Glycoprotein B Sequenzen, wurde entwickelt, um Augen-, Nasen- und Genitaltupferproben frei lebender Seehunde, Sattelrobben (Phoca groenlandica) und Klappmützenrobben (Crystophora crystata) aus der Arktis und Seebären (Arctocephalus gazella), Weddellrobben (Leptonychotes weddellii), und See- Elefanten (Mirounga leonida) aus der Antarktis auf PhHV-1 DNA zu untersuchen. Die erstmalige Detektion von PhHV-1 DNA in Genitaltupferproben wirft die Frage auf, inwiefern das Virus, ähnlich bovinen oder equinen Herpesviren, in Reproduktionsprobleme involviert sein könnte. Ein indirekter PhHV- 1 ELISA wurde entwickelt und Seehunde der Arktis sowie Seebären, Weddellrobbe, Krabbenfresser (Lobodon carcinophaga), Rossrobben (Ommatophoca rossii) und See- Elefanten der Antarktis wurden serologisch getestet. Serumproben von Seehunden über einen Zeitraum von 12 Jahren ermöglichten die Beobachtung dieser Population hinsichtlich PhHV-1 Seroprävalenzen über längere Zeit. Erstmals konnten Antikörper auch in Rossrobben und See-Elefanten festgestellt werden, was indiziert, dass diese Spezies empfänglich für PhHV-1 sind. Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Nikolaus Osterrieder (firstReferee), Prof. Dr. Alex Greenwood (furtherReferee), Prof. Dr. Morten Tryland (furtherReferee).

Subjects/Keywords: Herpesviridae; seals; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roth, S. J. (2012). Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen Populationsgebieten. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4766

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Roth, Swaantje Juliane. “Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen Populationsgebieten.” 2012. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-4766.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Roth, Swaantje Juliane. “Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen Populationsgebieten.” 2012. Web. 30 Mar 2020.

Vancouver:

Roth SJ. Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen Populationsgebieten. [Internet] [Thesis]. Freie Universität Berlin; 2012. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-4766.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Roth SJ. Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen Populationsgebieten. [Thesis]. Freie Universität Berlin; 2012. Available from: http://dx.doi.org/10.17169/refubium-4766

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

2. Fischer-Tenhagen, Carola. Using snifferdogs for diagnosing in animal reproduction.

Degree: 2019, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-26592

► Diese Habilitationsschrift befasst sich mit Untersuchungen zum Einsatz des Geruchs als Indikator physiologischer und pathologischer Prozesse. Als Beispiele dieser Anwendung in der veterinärmedizinischen Reproduktionsmedizin dienen… (more)

▼ Diese Habilitationsschrift befasst sich mit Untersuchungen zum Einsatz des Geruchs als Indikator physiologischer und pathologischer Prozesse. Als Beispiele dieser Anwendung in der veterinärmedizinischen Reproduktionsmedizin dienen die Bestimmung physiologischer Zustände am Beispiel der Brunst bei der Milchkuh und die Erkennung von Erkrankungen am Beispiel der bovinen Mastitis. Als weiteres Beispiel aus dem medizinischen Bereich dient die Suche nach Biomarkern für Krebserkrankungen des Menschen. Die Geruchshunde werden in den Arbeiten genutzt, um das Vorhandensein spezifischer Gerüche der obengenannten Zustände oder Prozesse darzustellen. Dabei werden die Ergebnisse der eigenen Arbeiten zu diesem Thema kritisch hinterfragt, evaluiert und mit den Studienergebnissen anderer Autorinnen und Autoren in Beziehung gesetzt. Einleitend werden wissenschaftliche Erkenntnisse zum Geruch und zum Geruchssinn zusammenfassend dargestellt. Anschließend wird die Bedeutung von Geruch als Symptom von Krankheiten in der Medizin früher und heute beschrieben. Die überdurchschnittliche Riechleistung und gute Trainierbarkeit des Hundes wird seit der Domestikation zur Unterstützung des Menschen bei der Jagd, aber auch zur Suche von gefährlichen oder illegalen Substanzen genutzt (Helton, 2009). Neben den klassischen Aufgaben der Menschen-, Sprengstoff- und Drogensuche werden Hunde auch eingesetzt um Schädlinge (Holzkäfer, Bettwanzen), Schimmel in Gebäuden oder Krankheiten des Menschen (Krebs, Diabetes) zu identifizieren (Browne et al., 2006). Im Rahmen dieser Arbeit wurden verschiedene Studien mit Geruchshunden in der Reproduktionsmedizin durchgeführt. Unter anderem werden Arbeiten zur Brunsterkennung beim Rind durch spezifische Gerüche und die Erkennung von Infektionen der Milchdrüse durch Staphylococcus aureus beschrieben. In den letzten 20 Jahren mehren sich Arbeiten zu diesen Themen mit wissenschaftlichem Anspruch. Die Evidenz dieser Arbeiten wird beurteilt und Herausforderungen und Limitierungen für wissenschaftliches Arbeiten mit Geruchshunden dargestellt. Insbesondere die Konzeption von objektiven Testverfahren für die Überprüfung der Geruchsleistung der Hunde bringt große Herausforderungen mit sich, die hier diskutiert werden. Nach kritischer Betrachtung werden Empfehlungen für einen bestmöglichen Testaufbau für Geruchstests mit Hunden gegeben. Advisors/Committee Members: female (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: Suchhund; Brunsterkennung; Geruchsdetektion; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fischer-Tenhagen, C. (2019). Using snifferdogs for diagnosing in animal reproduction. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-26592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fischer-Tenhagen, Carola. “Using snifferdogs for diagnosing in animal reproduction.” 2019. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-26592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fischer-Tenhagen, Carola. “Using snifferdogs for diagnosing in animal reproduction.” 2019. Web. 30 Mar 2020.

Vancouver:

Fischer-Tenhagen C. Using snifferdogs for diagnosing in animal reproduction. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-26592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fischer-Tenhagen C. Using snifferdogs for diagnosing in animal reproduction. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-26592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

3. Wallstab, Almut. Influence of three organ preservation solutions (HTK solution, Baeyer-2-solution, HTK solution with added iloprost) on the renal function in a model of isolated hemoperfused porcine kidney.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5822

► The composition of an organ preservation solution has a major influence on the functional quality of transplanted organs. Therefore in this study the influence of… (more)

▼ The composition of an organ preservation solution has a major influence on the functional quality of transplanted organs. Therefore in this study the influence of iloprost added to a common organ preservation solution on the renal function was examined. Iloprost, being an analogue of prostacyclin, has got vasodilatory and profibrinolytic effects and inhibits platelet aggregation. For this purpose a model of isolated hemoperfused porcine kidney established by v. Baeyer and Grosse-Siestrup was used. 18 kidneys of german landrace pigs were hypothermically preserved over a period of 2 hours after which they were perfused with autologous blood. Three different organ preservation solutions were used for the purpose of hypothermical preservation: HTK solution (group I), Baeyer-2-solution (group II) and HTK solution with added iloprost (group III). Each group contained 6 kidneys which were hemoperfused over a period of 180 minutes. Blood and urin samples were taken every 30 minutes to evaluate renal function using the following parameters: sodium, blood gases, hemoglobin, creatinine, glucose, total protein, osmolality. Blood pressure as well as flow rate of blood and dialysate were measured. The following parameters were then calculated: renal resistance, creatinine clearance, sodium reabsorption, tubular sodium transport, oxygen consumption, diuresis, ratios of urine / plasma osmolality, protein, creatinine and glucose. The values after 60, 120 and 180 minutes were used for statistical analysis. Regarding hemodynamic parameters kidneys of group II and III performed significantly better than those of group I. Blood flow rate after 180 minutes perfusion was 250ml/min*100g in group II and III whereas group I showed 136 ml/min*100g. Renal resistance after 180 minutes perfusion was 0,30 mmHg*min*100g/ml in group II, 0,35 mmHg*min*100g/ml in group III and 0,66 mmHg*min*100g/ml in group I. Hence the addition of iloprost significantly improved renal hemodynamics in group III compared to group I and proved to be similar effective as group II. Concerning functional parameters oxygen consumption stood out showing significant differences. Oxygen consumption in group III was significantly higher at all measurements compared to group I as well as after 60 and 120 minutes compared to group II (medians after 60/120/180 minutes: group I 139/112/117, group II 103/98/82, group III 203/171/165 (mol/min*100g). A possible reason could be less damage of functional nephrons and therefore better renal vitality in group III. Accordingly one would expect an increased tubular sodium transport which was the case in group III compared to group I. However, no significant differences were apparent among the three groups. Therefore an improved functionality could not be proven. Adding iloprost to HTK solution improves the preservation quality to some extent and seems to be similar effective as Baeyer-2-solution. Advisors/Committee Members: w (gender), PD Dr. Christian Große-Siestrup (firstReferee), Prof. Dr. Dr. David Groneberg (furtherReferee).

Subjects/Keywords: Prof. Dr. Karl Heinz Lahrmann; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wallstab, A. (2013). Influence of three organ preservation solutions (HTK solution, Baeyer-2-solution, HTK solution with added iloprost) on the renal function in a model of isolated hemoperfused porcine kidney. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5822

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wallstab, Almut. “Influence of three organ preservation solutions (HTK solution, Baeyer-2-solution, HTK solution with added iloprost) on the renal function in a model of isolated hemoperfused porcine kidney.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-5822.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vancouver:

Wallstab A. Influence of three organ preservation solutions (HTK solution, Baeyer-2-solution, HTK solution with added iloprost) on the renal function in a model of isolated hemoperfused porcine kidney. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-5822.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wallstab A. Influence of three organ preservation solutions (HTK solution, Baeyer-2-solution, HTK solution with added iloprost) on the renal function in a model of isolated hemoperfused porcine kidney. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-5822

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

4. Maksimov, Pavlo. Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii infections in humans and cats from Germany.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10766

► Several studies reported that certain T. gondii genotypes and clonal lineages correlate with severe toxoplasmosis in mice and humans. Therefore it may be important to… (more)

▼ Several studies reported that certain T. gondii genotypes and clonal lineages correlate with severe toxoplasmosis in mice and humans. Therefore it may be important to have information on the prevalence of different T. gondii genotypes in humans and animals. In future, this information may help to better estimate the risk of infection for humans and animals. Information on the genotype of T. gondii an individual human or animal is infected may allow to conclude on the further development of disease and to optimise treatment. The results of studies summarized in this cumulative thesis demonstrate that a peptidemicroarray assay can be used for diagnosis of T. gondii infection and to detect T. gondii clonal type-specific antibody responses in seropositive humans and cats. With a peptide microarray and sera from experimentally- infected and naturally-infected cats it was shown for the first time that cats are able to mount a clonal type-specific IgG antibody response against T. gondii. After validation, 27 peptides were selected which were suitable for T. gondii serotyping in cats. Previous work suggested that individuals in the study area were mainly exposed to T. gondii clonal type II. However, there was no information, which clonal type of T. gondii is most prevalent in infected humans, and there was only limited data about the distribution of T. gondii types in cats in Germany. The results of this study demonstrate that positive peptide reactions presenting clonal type II were statistically significantly overrepresented in the tested human and cat population. The intensity, by which type II peptides were recognized, was also significantly higher than the intensity with which peptides of other specificities were detected. The results suggest that most T. gondii infections in humans and cats were caused by T. gondii clonal type II in Germany and confirmed previous findings reporting a pre-dominance of type II in oocysts shed by cats in Germany. Since sporulated T. gondii oocysts present one of the most important sources of infection for intermediate hosts, it was expected that there were no major differences in serotyping results between those for cats and humans. These are the first peptide microarray-based serotyping studies on T. gondii infections in humans in Germany and the first in cats worldwide. However, further carefully validated typespecific peptides are necessary to optimize the specificity of serotyping. Further validation with a larger number of well- characterized sera may help to identify and select further polymorphic peptides with a diagnostic potential. The results summarized in the present thesis (publication 2, manuscript 3) demonstrate that propensity scale-based and ABCpred bioinformatic methods are suitable for the in-silico prediction of linear epitopes on T. gondii antigens. The propensity scale method identified nine polymorphic epitopes that could be used as part of a peptide panel for T. gondii serotyping in cats. Using ABCpred, eight novel linear epitopes were predicted, which could be… Advisors/Committee Members: m (gender), Prof. Dr. Franz Josef Conraths (firstReferee), PD Dr. Jürgen Krücken (furtherReferee), Univ.-Prof. Dr. Thomas Alter (furtherReferee).

Subjects/Keywords: Toxoplasma gondii; immunodiagnosis; classification; peptides; cats; man; Germany; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maksimov, P. (2013). Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii infections in humans and cats from Germany. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10766

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maksimov, Pavlo. “Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii infections in humans and cats from Germany.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-10766.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maksimov, Pavlo. “Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii infections in humans and cats from Germany.” 2013. Web. 30 Mar 2020.

Vancouver:

Maksimov P. Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii infections in humans and cats from Germany. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-10766.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maksimov P. Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii infections in humans and cats from Germany. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-10766

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

5. Falk, Anika. Measurement of the orbital cavity of dogs and cats in order to allow calculation of intraorbital prosthesis for implantation after enucleation.

Degree: 2017, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6177

► To agree to enucleation of one or both eyes is one of the largest (emotional) challenges for the patient’s owner in comparison to all surgeries… (more)

▼ To agree to enucleation of one or both eyes is one of the largest (emotional) challenges for the patient’s owner in comparison to all surgeries done in small animal medicine. The owner often gives higher priority to the cosmetic aspect than to the curative treatment of his pet. For this reason various options for the replacement of the missing volume of the globe were analyzed and developed. Nevertheless a perfect orbital substitute is not yet found. This problem was the reason to determine the dimensions of the orbit in dogs and cats in this study. Therefore, after the development of a suitable measurement method in preliminary work, computer tomographic images (Siemens Light Speed QXi, GE Medical Systems, Milwaukee WI, USA) of 40 dogs (1.4 to 16.6 years, 36 different breeds, 17 female, 23 male, 1.7-72.0 kg) and 40 cats (1-16 years, 13 breeds, 15 female, 25 male, 2.3-11.9 kg) were retrospectively evaluated. All dogs (13 brachycephalic, 22 mesaticephalic, 3 dolichocephalic) and cats (9 brachycephalic, 26 mesaticephalic, 5 dolichocephalic) were graded according to their head conformation. For the first time, sections of measurement for the reasonable and reproducible scales of the total bony orbit were elaborated. With the help of the program Eclipse (Varian Medical Systems, Inc., Düsseldorf) orbital structures were defined, volumes were calculated and the orbit was quantified in height, width and depth. Special attention was focused on the relation between the extension of the orbit and head shape respectively body height. Measuring the orbital height, only in dogs moderate differences were found concerning head conformation (p=0.160). In cats the orbital height is not influenced by the head conformation (p=0.707). There were significant differences in the width of the orbit in brachycephalic dogs (p<0.001) that are mainly influenced by a decreased Proc. frontalis of the Os zygomaticum. Moreover the orbital width of the different head conformations in cats showed significant differences (p=0.008). The results of the presented study did not confirm the previously suggested theory of brachycephalic animals possessing a flat orbit and dolichocephalic animals having a deep orbit (mean dogs: 3.45 cm brachycephalic, 3.39 cm mesaticephalic, 3.22 cm dolichocephalic; mean cats: 2.89 cm brachycephalic, 2.79 cm mesaticephalic, 2.55 cm dolichocephalic). Moreover anatomic characteristics in brachycephalics cats are the reason for this appearance. In brachycephalic dogs the formation of the Proc. frontalis is rather responsible for the position of the globe within the orbit and is providing the appearance of a protruding globe. In cats the appearance of a planar orbit is promoted through the shortening of the nasal bones, but does not stand in correlation to the orbital size. Nevertheless a significant influence of the body weight onto the extension of the orbit in dogs (p<0.001) and cats (p<0.001) could be proven. With increasing body weight the size of the orbital space rises. The extension of the orbit is positively correlated… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Corinna Eule (firstReferee), Univ.-Prof. Dr. Johanna Plendl (furtherReferee), Univ.-Prof. Dr. Christoph Lischer (furtherReferee).

Subjects/Keywords: cats; dogs; orbits; amputation; skull; measurement; prosthesis implantation; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Falk, A. (2017). Measurement of the orbital cavity of dogs and cats in order to allow calculation of intraorbital prosthesis for implantation after enucleation. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6177

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Falk, Anika. “Measurement of the orbital cavity of dogs and cats in order to allow calculation of intraorbital prosthesis for implantation after enucleation.” 2017. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-6177.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Falk, Anika. “Measurement of the orbital cavity of dogs and cats in order to allow calculation of intraorbital prosthesis for implantation after enucleation.” 2017. Web. 30 Mar 2020.

Vancouver:

Falk A. Measurement of the orbital cavity of dogs and cats in order to allow calculation of intraorbital prosthesis for implantation after enucleation. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-6177.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Falk A. Measurement of the orbital cavity of dogs and cats in order to allow calculation of intraorbital prosthesis for implantation after enucleation. [Thesis]. Freie Universität Berlin; 2017. Available from: http://dx.doi.org/10.17169/refubium-6177

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

6. Reinartz, Marion. Impact of the deep freezing process and frozen storage on the microflora of four commercial frozen food products.

Degree: 2012, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9442

► The aim of this study was to answer the question whether the way of industrial freezing and storing of food products leads to significant reductions… (more)

▼ The aim of this study was to answer the question whether the way of industrial freezing and storing of food products leads to significant reductions in the count of microorganisms. Therefor quantitative microbiological examinations of five samples per month from each of four frozen food products (“leak, sliced”, “mushrooms, sliced”, “Maultaschen-Gemüse- Pfanne”, “Stroganoff-Pfanne”) were conducted. The two raw vegetable products were also examined in the unfrozen status before the freezing process. With quantitative microbiological examinations of the products before the freezing process and monthly examinations during the frozen storage, information about the impact of the freezing process, the temperature and the storage time (with regard of type of product and its preprocessing) on the activity of the microorganisms was collected. Furthermore conclusions about the mortality and survival rate of the different bacteria species could be drawn. Each of the examined food belonged to one lot which was produced in December 2007. After the production, the food packages were stored at constant temperature of -24°C for one year at a frozen food company and sent monthly to our institute. The quantitative microbiological examination was conducted by drop plating for the following microorganisms: Aerobic mesophilic total bacteria, lactic acid bacteria, lactobacilli, coagulase-positive staphylococci, enterococci, Listeria monocytogenes, Bacillus cereus, sulfite-reducing anaerobe sporeforming bacteria, aeromonads, pseudomonads, Enterobacteriaceae, coliforms, E. coli, yeasts and molds. The reduction of the microbial count after the freezing process was between 0.30 and 2.25 log10 cfu/g. In the product “leak, sliced” significant reductions of the bacterial count for all included microorganisms were noticed while this was observed for only four types of bacteria in the product “mushrooms, sliced”. According to this, a matrix effect on the microorganisms during the freezing process can be expected. The one-year frozen storage caused for certain groups of bacteria a significant reduction in cell counts which were strongest for Enterobacteriaceae and coliforms. Lactic acid bacteria, lactobacilli, pseudomonads, yeasts and molds were much less susceptible. In our experiments the enterococci showed nearly the same correlation between counts and storing time as the coliforms. Hence, the information from literature that enterococci are better hygiene indicators for frozen food products than coliforms cannot be confirmed. If adding the impact of the freezing process and frozen storage over one year, the microbial reduction will not be enough to cause a complete decontamination. All microorganisms present at the beginning were still detectable at the end of the study. Listeria monocytogenes, coagulase-positive staphylococci, aeromonads, Bacillus cereus and sulfite-reducing anaerobe spore-forming bacteria could not be found in any sample or the number of these microorganisms was below the detection limit of 2.30 log10/1.00 log10 cfu/g. Beyond… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Goetz Hildebrandt (firstReferee), Univ.-Prof. Dr. Uwe Rösler (furtherReferee), Univ.-Prof. Dr. Reinhard Fries (furtherReferee).

Subjects/Keywords: Microorganisms; bacterial count; freezing; frozen foods; frozen storage; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reinartz, M. (2012). Impact of the deep freezing process and frozen storage on the microflora of four commercial frozen food products. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reinartz, Marion. “Impact of the deep freezing process and frozen storage on the microflora of four commercial frozen food products.” 2012. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-9442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reinartz, Marion. “Impact of the deep freezing process and frozen storage on the microflora of four commercial frozen food products.” 2012. Web. 30 Mar 2020.

Vancouver:

Reinartz M. Impact of the deep freezing process and frozen storage on the microflora of four commercial frozen food products. [Internet] [Thesis]. Freie Universität Berlin; 2012. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-9442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reinartz M. Impact of the deep freezing process and frozen storage on the microflora of four commercial frozen food products. [Thesis]. Freie Universität Berlin; 2012. Available from: http://dx.doi.org/10.17169/refubium-9442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

7. Hanke, Christine. Comparative studies of empty and with osteoinductive materials filled titanium cages for the cervical spine fusion applied to the animal model sheep.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4629

► In the course of the treatment of inflammatory and degenerative disc diseases, fractures and tumors of the vertebrae, the intervertebral spondylodesis gained more and more… (more)

▼ In the course of the treatment of inflammatory and degenerative disc diseases, fractures and tumors of the vertebrae, the intervertebral spondylodesis gained more and more clinical relevance in the last years. This therapy is aimed at a stable vertebral fusion. For decades, the tricortical iliac crest bone graft was considered as golden standard for interbody fusion of the cervical spine. The necessary biopsy of autologous material, however, often results in a significant morbidity among the patients. Subsidence, collapse or migration of the implant occur as well. This might result in kyphotic deformity or nonunion. These complications require a development of alternative intervertebral disc implants. The goal of this study was a radiological examination of the spondylodesis using an interbody titan-cage for stabilizing the intervertebral space. This implant was filled with four different concentrations of modified parathyroid hormone TGplPTH1-34 (0.2 mg/ml, 0.4 mg/ml, 0.7 mg/ml, 1.0 mg/ml). Three groups were used for monitoring: a group with an empty cage, a group implanted with cancellous bone graft and a group with fibrin. For this purpose fifty-six adult female merino-mix sheep underwent discectomy of segment C3/C4. Each monitoring group consisted of eight animals. After standing for twelve weeks, the animals were euthanized and the vertebrae C3 and C4 were removed. Utilizing the plain X-ray images that were taken preoperatively, postoperatively, after 8 weeks and post mortem after twelve weeks, the disc space height and the intervertebral angle were determined. The CT images for the subsequent bone density measurements were performed on the isolated cervical vertebrae. Based on the plain X-ray images and CT scans a fusion score was defined which describes the status of fusion after the twelve weeks. For the most part the radiological evaluation of all collected parameters showed significant differences between the monitoring groups. However, it was not possible to conclude a clear statement on the basis of radiographic data, because no group consistently dominated. There were crucial differences in the results of the groups in terms of the various examinations. In comparison to the monitoring group “empty cage” and “fibrin” the levels of PTH-groups were more promising and should be aligned with the results of histomorphology, histomorphometry and biomechanics. Advisors/Committee Members: w (gender), PD Dr. Christian Große-Siestrup (firstReferee), Univ.-Prof. Dr. Johanna Plendl (furtherReferee), Prof. Dr. Georg Bergmann (furtherReferee).

Subjects/Keywords: animal models; fibrin; intervertebral discs; parathyrin; radiography; sheep; spine; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hanke, C. (2013). Comparative studies of empty and with osteoinductive materials filled titanium cages for the cervical spine fusion applied to the animal model sheep. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4629

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hanke, Christine. “Comparative studies of empty and with osteoinductive materials filled titanium cages for the cervical spine fusion applied to the animal model sheep.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-4629.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hanke, Christine. “Comparative studies of empty and with osteoinductive materials filled titanium cages for the cervical spine fusion applied to the animal model sheep.” 2013. Web. 30 Mar 2020.

Vancouver:

Hanke C. Comparative studies of empty and with osteoinductive materials filled titanium cages for the cervical spine fusion applied to the animal model sheep. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-4629.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hanke C. Comparative studies of empty and with osteoinductive materials filled titanium cages for the cervical spine fusion applied to the animal model sheep. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-4629

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

8. Haimerl, Peggy. Ein evidenzbasierter Ansatz.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6661

► Entscheidungsfindungen in der täglichen tierärztlichen Praxis und Wissenschaft sowie durch Mitarbeiter landwirtschaftlicher Betriebe sollten stets auf objektiven Informationen basieren. Deshalb gewinnt die Anwendung der Evidenzbasierten… (more)

▼ Entscheidungsfindungen in der täglichen tierärztlichen Praxis und Wissenschaft sowie durch Mitarbeiter landwirtschaftlicher Betriebe sollten stets auf objektiven Informationen basieren. Deshalb gewinnt die Anwendung der Evidenzbasierten Medizin zunehmend an Bedeutung. Allerdings sehen wir in der Veterinärmedizin einen Mangel an gründlich und systematisch durchgeführten groß angelegten klinischen Studien, was wiederum einen Mangel an Forschungsergebnissen hoher Evidenz nach sich zieht. Zusätzlich beobachtet man eine enorme Variation hinsichtlich der Qualität veterinärmedizinischer Studien. Daher basiert der Wissenszuwachs im veterinärmedizinischen Bereich v.a. auf Erfahrungsberichten anstatt auf randomisierten, kontrollierten klinischen Studien. Randomisierte, kontrollierte, doppelt verblindete Studien stellen jedoch den Goldstandard bezüglich der Beurteilung einer bestimmten Behandlungsstrategie dar. Postpartale Gebärmutterentzündungen stellen mit einer Prävalenz von bis zu 57,7% eine häufige Störung bei der Milchkuh dar. Diese verursachen aufgrund von beträchtlichen negativen Auswirkungen auf die Folgefruchtbarkeit hohe Zusatzkosten für die Landwirte. Daher war es das übergreifende Ziel der durchgeführten Studien, den Status Quo hinsichtlich der Evidenz der verfügbaren Literatur sowie der Anwendung bzw. der Umsetzung der Evidenzbasierten Veterinärmedizin (EBVM) einmal näher zu beleuchten. In einer ersten Studie wurde die Qualität und Vergleichbarkeit der verfügbaren Literatur zum Thema Behandlung der bovinen Endometritis mit PGF2α ausgewertet. Dafür wurden mithilfe einer umfassenden, systematischen Literaturrecherche in Online Datenbanken bzw. Suchmaschinen 2723 Referenzen zu der untersuchten Thematik gefunden. Nach Anwendung spezifischer Ausschlusskriterien verblieben 68 Studien für eine weitere Auswertung. Diese Artikel wurden mithilfe eines speziellen Bewertungsbogens hinsichtlich spezifischer Parameter, wie z.B. dem Vorhandensein einer Kontrollgruppe sowie der Zuordnung zu den einzelnen Gruppen, beurteilt. Diese Auswertung zeigte, dass mehr als die Hälfte der Studien (51,5%) älter als 20 Jahre waren. Zusätzlich zeigte sich, dass etwa ein Drittel (36,8%) der untersuchten Studien kontrolliert und randomisiert waren, während 3 dieser Studien (4,4%) zusätzliche verblindet durchgeführt worden waren. Zusammenfassend lässt sich sagen, dass die Forschungsergebnisse hinsichtlich der Wirksamkeit von PGF2α sehr unterschiedlich sind. Aufbauend auf die erste Studie zielte die zweite Studie auf die quantitative metaanalytische Bewertung der Behandlung der chronischen Endometritis der Kuh mittels PGF2α ab. Nach der Anwendung spezifischer Ausschlusskriterien und der Bewertung der verbliebenen Studien hinsichtlich bestimmter Evidenzparameter konnten 5 Publikationen, welche insgesamt 6 Studien umfassten, in die Metaanalyse eingeschlossen werden. Die Extraktion und Auswertung der Studiendaten erfolgte unter Verwendung des Review Managers 5.1. Dabei wurden mithilfe dieser Software Effektgrößen bezüglich der Auswirkung einer PGF2α… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Wolfgang Heuwieser (firstReferee), Univ.-Prof. Dr. Holger Martens (furtherReferee), Univ.-Prof. Dr. Heidrun Fink (furtherReferee).

Subjects/Keywords: cows; dairy cattle; puerperium; endometritis; treatment; prostaglandins; meta-analysis; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haimerl, P. (2013). Ein evidenzbasierter Ansatz. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6661

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haimerl, Peggy. “Ein evidenzbasierter Ansatz.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-6661.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haimerl, Peggy. “Ein evidenzbasierter Ansatz.” 2013. Web. 30 Mar 2020.

Vancouver:

Haimerl P. Ein evidenzbasierter Ansatz. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-6661.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haimerl P. Ein evidenzbasierter Ansatz. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-6661

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

9. Gerling, Corinna. Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring.

Degree: 2018, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-41

► Even today Trakehners have a special position in German horse breeding, as this breed is the oldest breed of riding horse in Germany. Since the… (more)

▼ Even today Trakehners have a special position in German horse breeding, as this breed is the oldest breed of riding horse in Germany. Since the beginning of the breeding history of Trakehners, these horses were bred as noble riding and driving horses, whereby the type, stamina and performance capabilities were determined by English and Arabian Thoroughbreds. A rebreeding from heavy warmbloods, which were used in agriculture, to noble light riding horses never happened, because Trakehners were always recruited for the cavalry as light riding and driving horses. Due to the massive introduction of Thoroughbreds, the horses were too light and passed through several strengthening periods. Following World War II only a few breeding horses were available for the reintroduction of breeding. Through the establishment of the Eastern Block, subpopulations could be formed, which were also bred in the former Soviet Union according to pure breeding criteria. In order to preserve their special genetic structure the breeding methods of pure breeding were retained up to the present day. All further warmblood breeding associations bred with variably open stud books. By pure breeding the special genetic structure can be maintained but the small population necessitates good organization in order to maintain the incest rate at the lowest possible level. The special conditions of pure breeding enable an inclusion of genes from English and Arabian Thoroughbreds, as well as Shagya Arabians and Anglo-Arabians and pure-bred Trakehners from abroad. This enlargement of the gene pool has a traditional foundation, enlarges the variance and reduces the incest rate. Nowadays, Trakehners are bred worldwide. Several daughter associations have been formed for supporting foreign breeders. For this investigation the performance characteristics of the actively breeding mare population from the year 2014 were examined in correlation to the special blood contingent of the mares. Using a pedigree analysis the mares were subdivided into five groups with respect to increasing proportions of their special blood contingent in the first two generations. Special blood was defined as ancestors of the breeds English Thoroughbred, Arabian Thoroughbred, Shagya Arabians, Anglo-Arabians and horses from the foreign subpopulation. In total the central data from the Trakehner Zuchtverband (Trakehner Breeding Association) and the FN (German Riding Association) from 9915 horses were evaluated. In the first part of the evaluation it could be shown that more than one third of actively breeding registered mares had a special blood contingent of 25% and more. A high level of special blood has therefore also been established in the previous generations. In the second part the performance-related data of the mares and their offspring were analyzed. The performance data investigated are selection criteria in the breeding program. Data from the foal registration, stud book entries, mare performance tests and tournaments were included. Stallion performance tests and licensing… Advisors/Committee Members: female (gender), Handler, Johannes (firstReferee), Gehlen, Heidrun (furtherReferee), Staufenbiel, Rudolf (furtherReferee).

Subjects/Keywords: horses; Trakehner; animal breeding; blood; pedigree; breeding value; studbooks; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gerling, C. (2018). Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-41

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gerling, Corinna. “Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring.” 2018. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-41.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gerling, Corinna. “Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring.” 2018. Web. 30 Mar 2020.

Vancouver:

Gerling C. Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-41.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gerling C. Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-41

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

10. Mücke, Ines. Evaluation of follicular development, occurence of ovulation and time of ovulation after progesterone and PGF2α.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-10729

► The aim of this study was to evaluate the influence of the estrous cycle stage at the beginning of treatment with a progesterone releasing intravaginally… (more)

▼ The aim of this study was to evaluate the influence of the estrous cycle stage at the beginning of treatment with a progesterone releasing intravaginally device (PRID), with and without estradiol (PRIDα), and PGF2α. To determine the effect of the treatment, different parameters were evaluated including follicle growth and serum steroid concentrations. In addition, the intervalls between insert removal and LH-surge and insert removal and ovulation were measured. Finally, the efficacy of this treatment regime was evaluated in view of synchrony of ovulations and a successful single fixed-timed insemination. In experiment I six Fleckvieh heifers per group were treated with the PRID insert on day ¾ (group 1), day 11/12 (group 2) or day 17/18 (group 3) of the cycle. After 9 days the PRID was removed and PGF2α was administered. In experiment II heifers were used as in experiment I (group 4 – 6), but the PRID was used without the estradiol capsule (PRIDα). In all groups blood samples were taken at the beginning, during and after the treatment to assess the serum progesterone concentrations. After this treatment the blood estradiol concentrations were determined. Ultrasonography was used for ovary diagnostic on day 1, 4, 7 and 10 of the experiment to determine the presence or absence of follicles and corpora lutea. In order to detect the LH-surge, serum samples were taken in all groups every two hours starting 40 h after insert removal until the diagnosis of ovulation could be reached via ultrasonography, which was carried out every six hours starting 66 h after insert removal. Seven days following the estrous a blood sample to assess progesterone levels was taken. In experiment III eightteen heifers were treated irrespectively of their stage of cycle with PRIDα and PGF2α. 50 h after removal of PRIDα, GnRH was injected intramuscularly and after 13 h artificial insemination was performed. Blood samples to assess progesterone levels were taken as in experiment I and II. In order to detect the LH-surge serum samples were taken 40 h after removal of the PRIDα until two hours after the GnRH-application. Ovary ultrasonography was performed 72 h after insert removal to determine the onset of ovulation. The succes of conception was tested by flushing the ipsilateral uterus horn on day seven of the cycle. There was no significant difference between the number of succesfully induced estrous in experiment I (83.3 % PRID) and experiment II (88.8 % PRIDα). The numbers of follicles >10 mm at the start of treatment were smaller for heifers in group 1 compared with heifers in group 2 or 3. There was no difference regarding the numbers of follicles >10 mm between groups 4 – 6. At day four of the treatment heifers in group 1 had a significant smaller number of follicles >10 mm than at day 7 and 10. In group 2, the number of follicles >10 mm were smaller on day 7 compared to day 10. In group 5, the number of follicles was significant higher on day 7 than on day 1. The comparison of the number of follicles >10 mm between the treatments with… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. med. vet. W. Heuwieser (firstReferee), Prof. Dr. rer. nat. habil. Klaus-Peter Brüssow (furtherReferee), Univ.-Prof. Dr. med. vet. A. Sobiraj (furtherReferee).

Subjects/Keywords: progesterone; heifers; follicles; ovulation; LH; estradiol; prostaglandins; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mücke, I. (2013). Evaluation of follicular development, occurence of ovulation and time of ovulation after progesterone and PGF2α. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10729

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mücke, Ines. “Evaluation of follicular development, occurence of ovulation and time of ovulation after progesterone and PGF2α.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-10729.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mücke, Ines. “Evaluation of follicular development, occurence of ovulation and time of ovulation after progesterone and PGF2α.” 2013. Web. 30 Mar 2020.

Vancouver:

Mücke I. Evaluation of follicular development, occurence of ovulation and time of ovulation after progesterone and PGF2α. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-10729.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mücke I. Evaluation of follicular development, occurence of ovulation and time of ovulation after progesterone and PGF2α. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-10729

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

11. Drumm, Niklas Julius. Factors influencing pregnancy in thoroughbred mares following colic surgery.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14483

► Colic surgery in the pregnant broodmare raises concerns not only for the mare, but also for a prospective foal. Previous studies investigated abortion/foaling rates following… (more)

▼ Colic surgery in the pregnant broodmare raises concerns not only for the mare, but also for a prospective foal. Previous studies investigated abortion/foaling rates following medical and surgical management of colic in pregnant mares. Foaling rates for pregnant mares following colic surgery were found to be 53.8 to 80% (BOENING and LEENDERTSE, 1993; CHENIER and WHITEHEAD, 2009; SANTSCHI et al., 1991). Conclusions were inconsistent between these studies regarding the influence of duration of anesthesia, signs of endotoxemia, and intraoperative hypotension or hypoxemia. The purpose of this study was to determine the influence of gestational age on foaling rates of pregnant Thoroughbred mares following colic surgery and to evaluate potentially influencing perioperative factors. The medical records of Thoroughbred mares, which had colic surgery performed from 1993 through 2007 at the Rood and Riddle Equine Hospital in Lexington, Kentucky, USA, were reviewed. Mares that were considered to be pregnant during the colic surgery, survived to hospital discharge and were registered with the North American Jockey Club were included. Age of the mare, date of surgery, gestational age, duration of colic at admission, packed cell volume at admission, surgical diagnosis, duration of anesthesia, intraoperative hypotension, intraoperative hypoxemia, surgeon and administration of gestagens and polymixin B were recorded. Additionally, physical examinations recorded within 72 hours post surgery were reviewed for signs of postoperative endotoxemia: fever (rectal temperature of ≥37.6°C), el evated heart rate (>48/min), leucopenia (white blood cell count of <5000/l) and diarrhea. Information regarding foaling after surgery, the season before the surgery and the season after the surgery was obtained from the North American Jockey Club, Lexington, Kentucky, USA. Mares were considered to have had live foals, if the foals were registered with the North American Jockey Club. Odds ratios with 95%-confidence limits were calculated to estimate the effects of the various factors on the foaling rate. For mares determined pregnant prior to admission (>15 days of gestation), 152 of 228 (66.7%) had a live foal after colic surgery. Gestational age at the time of surgery affected foaling rate significantly. Mares pregnant for 16-39 days at surgery had a lower foaling rate compared with mares pregnant for ≥40 days: 48.7 (19/39) vs. 69.8% (118/169) (OR=0.41 [0.20, 0.83], P = 0.012). Other factors influencing foaling rate were mares age (P = 0.001) and duration of colic before surgery (P = 0.03). There was a trend for duration of anesthesia (P = 0.06), intraoperative hypotension (P = 0.07) and surgeon (0.06) to affect foaling rate. There was no significant influence on foaling rate detected for packed cell volume prior to surgery, surgical diagnosis, intraoperative hypoxia, postoperative signs of endotoxemia and administration of polymixin B. Foaling rate in the season before surgery was 76.8% and in the season after surgery 59.2%. There was no statistical… Advisors/Committee Members: m (gender), Univ.-Prof. Dr. Johannes Handler (firstReferee), Univ.-Prof. Dr. Rudolf Staufenbiel (furtherReferee), Univ.-Prof. Dr. Leo Brunnberg (furtherReferee).

Subjects/Keywords: Colic; mares; foaling rate; laparotomy; pregnancy; retrospective studies; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Drumm, N. J. (2013). Factors influencing pregnancy in thoroughbred mares following colic surgery. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Drumm, Niklas Julius. “Factors influencing pregnancy in thoroughbred mares following colic surgery.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-14483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Drumm, Niklas Julius. “Factors influencing pregnancy in thoroughbred mares following colic surgery.” 2013. Web. 30 Mar 2020.

Vancouver:

Drumm NJ. Factors influencing pregnancy in thoroughbred mares following colic surgery. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-14483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Drumm NJ. Factors influencing pregnancy in thoroughbred mares following colic surgery. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-14483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

12. Biedermann, Melanie. Evaluation of new methods for local tumor therapy in a VX2 rabbit model.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12262

► In many cases, only advanced stage colorectal cancer is diagnosed. At this point, it has often already metastasised to the liver. In these cases, not… (more)

▼ In many cases, only advanced stage colorectal cancer is diagnosed. At this point, it has often already metastasised to the liver. In these cases, not only the patient’s primary tumor, but also metastases have to be treated. For the treatment of both liver metastases and primary tumors there are local procedures to be offered. The objective of this project was to investigate new methods of local therapy of liver tumors/ metastases, which can be used either as neoadjuvant, adjuvant or stand-alone treatment. It was the aim of this study to investigate minimally invasive local tumor therapy using a low dose of drugs. The study on efficacy and tolerance of this method was conducted in 20 rabbits with implanted VX2 liver tumors. The initial idea was to allow local percutaneous treatment of tumors with therapeutically active substances delivered by drug-coated balloon catheters. In this way, a large tissue surface area will be attained by the increased surface of the balloon through its expansion. In addition, the coating will be sustainably pressed into the tumor tissue. After that, the active substance should be slowly dissolved in the tissue or slowly washed away from its location. The following cytostatics were selected: paclitaxel, arsenic trioxide, 5-fluorouracil, fantolon, bortezomib, doxorubicin and mitoxanthrone. In addition, the drugs were compared with appropriate drug-free controls. The above mentioned substances were tested in vitro for their cytotoxicity against the VX2 tumor cells in culture. The cells were exposed to any substance at four different concentrations (2-32 μmol/l for paclitaxel, arsenic oxide, fantolon, 5-fluorouracil and mitoxanthrone, 10- 25 μmol/l for doxorubicin, 0.1-0.4 μmol/l for bortezomib) for 24, 48 and 72 hours. As a control, tumor cells were incubated without drugs. The total remaining intramitochondrial dehydrogenase activity as a measure of the cellular vitality compared to the control was the lowest for doxorubicin with 12 3% (16 μmol/l after 72 h incubation) and the highest for arsenic trioxide with 52 4% (15 μmol/l after 48 h) when the lowest value was selected for each substance. All tested substances were shown to be effective, and their selection for the investigation in the animal study was based on their physicochemical properties and mechanism of action, as well as on the experience with these substances in previous studies for other indications. Not all test substances selected in this study were shown to be suitable for the coating of balloon catheters, thereby limiting this method of administration in the in vivo experiments. For that reason another mode of administration of these substances had to be chosen. Arsenic trioxide and doxorubicin were injected directly into the tumor using a syringe (four animals per group). Four rabbits were used for each drug to be tested. The applied doses were between 1.57 to 1.78 mg for paclitaxel, 11.5 to 22.0 mg for arsenic trioxide, 1.12 to 1.16 for fantolon and 5.94 to 20.78 for doxorubicin. In the course of the study the doses for… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Johanna Plendl (firstReferee), Univ.-Prof. Dr. Matthias Taupitz (furtherReferee), Univ.-Prof. Dr. Robert Klopfleisch (furtherReferee).

Subjects/Keywords: rabbits; therapy; tumours; catheters; injection; cytotoxic compounds; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Biedermann, M. (2013). Evaluation of new methods for local tumor therapy in a VX2 rabbit model. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12262

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Biedermann, Melanie. “Evaluation of new methods for local tumor therapy in a VX2 rabbit model.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-12262.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Biedermann, Melanie. “Evaluation of new methods for local tumor therapy in a VX2 rabbit model.” 2013. Web. 30 Mar 2020.

Vancouver:

Biedermann M. Evaluation of new methods for local tumor therapy in a VX2 rabbit model. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-12262.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Biedermann M. Evaluation of new methods for local tumor therapy in a VX2 rabbit model. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-12262

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

13. Stubbe, Angela geb. Rohder. Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh poultry and minced beef sold in retail markets in Berlin.

Degree: 2011, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6443

► The objective of this study was to reassess the alternatives for the detection of Arcobacter spp. in fresh meat and to collect data on the… (more)

Subjects/Keywords: Arcobacter; food contamination; poultry meat; beef; isolation; identification; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stubbe, A. g. R. (2011). Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh poultry and minced beef sold in retail markets in Berlin. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6443

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stubbe, Angela geb Rohder. “Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh poultry and minced beef sold in retail markets in Berlin.” 2011. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-6443.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vancouver:

Stubbe AgR. Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh poultry and minced beef sold in retail markets in Berlin. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-6443.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stubbe AgR. Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh poultry and minced beef sold in retail markets in Berlin. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-6443

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

14. Sanguankiat, Arsooth. Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7636

► Diese Untersuchung erfolgte innerhalb eines größeren Vorhabens vom Dezember 2004 bis Mai 2005 in Chiang Mai und der Provinz Lamphun in Nord- Thailand. 193 Schlachtschweine… (more)

▼ Diese Untersuchung erfolgte innerhalb eines größeren Vorhabens vom Dezember 2004 bis Mai 2005 in Chiang Mai und der Provinz Lamphun in Nord- Thailand. 193 Schlachtschweine (22 unterschiedliche Mastgruppen) wurden individuell bereits in der Herkunft beprobt und bis in den Schlachtbetrieb hinein individuell verfolgt. Die Probenahme erfolgte weiterhin auf individueller Basis über die Schlachtung und Bearbeitung, Zerlegung, Transport und Verkauf. Hierfür standen 1.000 Isolate zur Verfügung. Die Gesamtprävalenz von Salmonella in allen Proben lag bei 48,9 % (971 von 1982 Proben). Tränkwasser und Wasser zur Reinigung lagen beide bei 13,6 %. Schmutzwasser war fast vollständig Salmonella- positiv (95,5 %), ebenso wie die eingesetzten Sockenproben (94,8 %). Im Schlachtbetrieb und Schlachtgruppen- bezogen, wurde der höchste Prozentsatz positiver Proben in der Zerlegung mit 23 % gefunden. Einzeltierbezogen wurde die niedrigste Quote mit 12,9 % nach dem Abwaschen der Tierkörper erzielt. Zwischen den Fäkalproben nach dem Transport und den Mesenterial-Lymphknotenproben war der Unterschied nur gering (61,4 % und 63,9 %). Nach dem Spalten der Tierkörper war die Prävalenz ca. 2,5 mal höher als nach dem Waschen. Der Caecum-Inhalt erbrachte die höchste Prävalenz (83,1 %). Die Nachweisrate war abhängig von der Probenahmestelle und der Sendung. Der höchste Korrelationskoeffizient fand sich zwischen den Positionen, nach dem Waschen“ und „Frischfleisch nach dem Zerlegen“ (rs = 0,66; P = 0,0014), was auf Zusammenhänge zwischen den Positionen hindeutet. Das Relative Risiko war hier signifikant (1,64; 95% CI: 1,294 – 2,089). Der Nachweis von Salmonellen nach dem Waschen erhöhte die Wahrscheinlichkeit (OR = 3,9; P = 0,039), daß auch Frischfleisch nach dem Zerlegen Salmonella- positiv war. Die Wahrscheinlichkeit positiver Proben nach dem Transport erhöhte sich, wenn auch die Zerlege-Unterlagen positiv waren (OR = 3,9; P = 0,042), auch, wenn die Sockenproben bereits positiv waren (OR = 5,5; P = 0,01). Der Nachweis in den Mesenterial- Lymphknoten erhöhte die Wahrscheinlichkeit des Nachweises von positivem Caecal-Inhalt (OR = 2,3; P = 0,045) und von positivem Frischfleisch nach dem Zerlegen (OR = 2,0; P = 0,03). Insgesamt wurden 26 Serovaren identifiziert. Salmonella Rissen war vorherrschend mit 45,9 % der Isolate. 7 Serovaren (S. Anatum, Krefeld, Panama, Rissen, Stanley, Typhimurium und Weltevreden) wurden entlang der gesamten Kette nachgewiesen (Farm, Schlachtbetrieb, Vertrieb), darunter die am häufigsten nachgewiesenen Serovaren (S. Rissen, Typhimurium, Stanley). 11 Serovaren (S. Afula, Agona, Alfort, Bovismorbificans, Chittagong, Corvallis, Derby, Hato, Israel, Langensalza, Regent und Rideau) wurden nur in Farm- Proben einschließlich der Faeces der Tiere nach dem Transport nachgewiesen. 3 Serovaren (S. Eppendorf, Livingstone und Tsevie) wurden nur aus Proben im Schlachtbetrieb, eine Serovar (S. Enteritidis) wurde nur aus dem Vertrieb und nur aus einer Probe isoliert. Die Dendrogramme der PFGE („Pulsotypen“) von S. Krefeld, S. Panama und S.… Advisors/Committee Members: m (gender), Univ.-Prof. Dr. Reinhard Fries (firstReferee), Univ.-Prof. Dr. Lothar H. Wieler (furtherReferee), Univ.-Prof. Dr. Uwe Rösler (furtherReferee).

Subjects/Keywords: pigs; pork; Thailand; Salmonella; serovars; pulsed-field electrophoresis; typing; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sanguankiat, A. (2014). Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sanguankiat, Arsooth. “Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand.” 2014. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-7636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sanguankiat, Arsooth. “Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand.” 2014. Web. 30 Mar 2020.

Vancouver:

Sanguankiat A. Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-7636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sanguankiat A. Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-7636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

15. Suppan, Lilian. MR-guided high-intensity focused ultrasound for renal sympathetic denervation – a feasibility study in pigs.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5021

► Hypertension is one of the most common medical conditions amongst people in developed countries, and it can have fatal consequences for the cardiovascular system. Most… (more)

▼ Hypertension is one of the most common medical conditions amongst people in developed countries, and it can have fatal consequences for the cardiovascular system. Most patients suffer from resistant hypertension and cannot be treated by common antihypertensive drugs. Recent findings have shown that overactivity of the sympathetic nervous system plays an important role in the development of hypertension. This has lead scientists to explore and develop new minimal invasive treatment methods to degenerate renal sympathetic nerve fibres located around the renal arteries, thereby preventing this overactivity. One established method is catheter-based radiofrequency ablation. An endovascular catheter is inserted in the femoral artery in the inguinal region and pushed forward to the renal artery. Radiofrequency energy is then applied to the adventitia of the renal artery. However, this approach is unavailable to patients who have certain anatomic characteristics. This has therefore led us to search for new, non-invasive treatment methods for renal denervation. Magnetic resonance-guided, high-intensity focused ultrasound (MRg HIFUS) is a non-invasive, ablative method that is currently used primarily for the treatment of uterine fibroids. We therefore undertook this study to evaluate the safety and efficacy of MR-guided high-intensity focused ultrasound for renal sympathetic denervation in a porcine model. A total of ten pigs were used in this study, one of which was a sham pig and was not treated. During the MRg HIFUS intervention all pigs were placed under general anaesthesia using propofol. They were then treated with MRg HIFUS along the right renal artery. Two of the pigs were sacrificed straight after the MRg HIFUS treatment, the other eight pigs were sacrificed 28 days later. Both kidneys were removed and homogenized using formic acid. Samples of the kidneys were then examined for their concentration of norepinephrine using high pressure liquid chromatography and electrochemical detection. Renal arteries and urethras were preserved in formalin, histologically processed, and stained with HE and EvG staining. Degenerative sympathetic nerve fibres could be easily detected after this staining. In three of the nine pigs perivascular oedema indicating thermal tissue damage was diagnosed on the T2w FSE sequences taken after the HIFUS treatment. Furthermore, the norepinephrine concentrations in the treated kidneys of the pigs did not drop significantly, something that would also have indicated the treatment was successful. During the histological examination, perineural fibrosis, indicating degenerated sympathetic nerve fibres, was visible in one of the pigs. All pigs tolerated the treatment very well and there were no serious complications. Three of the nine pigs treated displayed superficial skin burns following the MRg HIFUS treatment. The results showed that pigs are not suitable subjects for MRg HIFUS treatment as a result of long lumbar transverse processes and a dominant fascia thoracolumbalis. Nine pigs treated with MRg… Advisors/Committee Members: w (gender), Univ.- Prof. Dr. Johannes Handler (firstReferee), PD Dr. Florian Streitparth (furtherReferee), Univ.- Prof. Dr. Robert Klopfleisch (furtherReferee).

Subjects/Keywords: pigs; animal models; hypertension; ultrasound; magnetic resonance imaging; ultrasonics; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Suppan, L. (2015). MR-guided high-intensity focused ultrasound for renal sympathetic denervation – a feasibility study in pigs. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Suppan, Lilian. “MR-guided high-intensity focused ultrasound for renal sympathetic denervation – a feasibility study in pigs.” 2015. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-5021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Suppan, Lilian. “MR-guided high-intensity focused ultrasound for renal sympathetic denervation – a feasibility study in pigs.” 2015. Web. 30 Mar 2020.

Vancouver:

Suppan L. MR-guided high-intensity focused ultrasound for renal sympathetic denervation – a feasibility study in pigs. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-5021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Suppan L. MR-guided high-intensity focused ultrasound for renal sympathetic denervation – a feasibility study in pigs. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-5021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

16. Kreausukon, Khwanchai. Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL produzierende E. coli).

Degree: 2011, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11495

► Das Ziel der Studie war, Informationen über den Einsatz von Antibiotika in deutschen Milchkuhherden zu sammeln. Zudem sollte auf das Vorkommen von MRSA und ESBL-produzierenden… (more)

▼ Das Ziel der Studie war, Informationen über den Einsatz von Antibiotika in deutschen Milchkuhherden zu sammeln. Zudem sollte auf das Vorkommen von MRSA und ESBL-produzierenden E. coli in Tankmilchproben untersucht werden. Fragebögen wurden unter den Herdenmanagern von 60 norddeutschen Betrieben (Herdengröße von 25 bis 3000 Tiere) verteilt, die auf freiwilliger Basis an den Untersuchungen teilnahmen. Tankmilchproben wurden in den Betrieben einmalig entnommen und auf das Vorkommen von MRSA und ESBL-produzierenden E. coli untersucht. Zusätzlich wurden MRSA-Isolate aus Milch aus der Stammsammlung des Nationalen Referenzlabors für koagulase-positive Staphylokokken (inklusive S. aureus) (NRL Staph) mittels Multiplex PCR, Sccmec-Typisierung, spa-Typisierung und einem DNA-Microarray analysiert. Die Herdenmanager benannten Lahmheiten, Metritiden und Mastitiden als häufigste Krankheitsprobleme der Kühe ihrer Betriebe. Neonataler Kälberdurchfall und der Kälbergrippekomplex (BRD) wurden als Hauptprobleme bei Kälbern angegeben. Beta-Lactame, Tetrazykline, Makrolide, Sulfonamide, Fluoroquinolone, Aminoglykoside, Phenikole und Polypeptide waren die für erkrankte Tiere eingesetzten Antibiotikaklassen auf den Betrieben. Ein Cephalosporin der dritten Generation – Ceftiofur –, das zur Behandlung der Unterfußphlegmone (Panaritium) zugelassen ist, war das zur Behandlung von Lahmheiten der Kühe meist genutzte Antibiotikum. Amoxicillin, Tetrazykline und Ceftiofur wurden bevorzugt zur Behandlung von Metritiden eingesetzt. BRD bei Kälbern wurde zumeist mit Florfenicol or Makroliden behandelt, während Fluoroquinolone die Mittel der Wahl bei Durchfallkälbern waren. Nach Angaben der Herdenmanager wurden monatlich im Durchschnitt 2.5% der Kühe aufgrund einer klinischen Mastitis behandelt. In solchen Fällen wurden routinemässig Milchproben zur bakteriologischen Untersuchung eingeschickt, seltener Proben von Kühen mit erhöhten somatischen Zellzahlen. Für die Behandlung von Mastitiden wurden Cefquinom, Penizillin und die Kombinationen Cefalexin+Kanamycin und Ampicillin+Cloxacillin als häufigste genutzte Antibiotika angegeben. Die meisten der untersuchten Betriebe (85% der Betriebe) wenden Routineverfahren zum Trockenstellen an. Dies beeinhaltet eine intramammäre Applikation von Antibiotika. Cloxacillin und Cefquinom und die Kombination von Penethamathydrojodid + Benethamin-Penizillin + Framycetinsulfat wurden am häufigsten zum Trockenstellen eingesetzt. Insgesamt wurden 36 MRSA-Isolate aus Kuhmilch charakterisiert. Fünf Isolate wurden dabei aus Tankmilchproben, die während der Betriebsbesichtigungen genommen wurden, gewonnen. 31 Isolate stammten aus der Stammsammlung des NRL Staph. Die Zuordnung der Isolate zu MRSA wurde Mithilfe einer Multiplex PCR und DNAMicroarrayanalysen verifiziert. Zwei verschiedene spa-Typen konnten ermittelt werden: t011 (22 Isolate) und t034 (14 Isolate). Dabei konnten 33 Stämme dem SCCmec Typ V, 2 Stämme dem SCCmec Typ III und nur ein Stamm dem SCCmec Typ IVa zugeordnet werden. Alle MRSA-Stämme zeigten im Phänotyp… Advisors/Committee Members: m (gender), Univ.-Prof. Dr. Kerstin E. Müller (firstReferee), PD Dr. Bernd-Alois Tenhagen (furtherReferee), Univ.-Prof. Dr. Karl-Hans Zessin (furtherReferee).

Subjects/Keywords: Germany; dairy cattle; drug therapy; drug resistance; Escherichia coli; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kreausukon, K. (2011). Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL produzierende E. coli). (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11495

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kreausukon, Khwanchai. “Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL produzierende E. coli).” 2011. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-11495.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vancouver:

Kreausukon K. Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL produzierende E. coli). [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-11495.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kreausukon K. Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL produzierende E. coli). [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-11495

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

17. Tastutar, Timurhan. an educational medium.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5575

► This Dissertation contains an educational medium which was created for veterinary students and veterinarians alike. It deals with cardiologic content for a more precise observation… (more)

▼ This Dissertation contains an educational medium which was created for veterinary students and veterinarians alike. It deals with cardiologic content for a more precise observation of the heart valve insufficiencies of the Horse. Cardiology is an essential part of the veterinary profession and a crucial part of the overall check-up. The traditional educational methods are in need of improvement. This also applies to sonographic cardiology. The support of multimedia content is still missing while obtaining field competence. Visual educational media is necessary to learn and understand the fundamentals of cardiological examination and heart diseases. The three- dimensional observation allow a better observation and evaluation of the functions and disorders of the heart valves. This ensues through an innovative 3D-visualisation implemented in an E-Learning environment. The goal of this dissertation is to fill the gap between the veterinary education and the professional experience. To reach this goal, a virtual heart model was designed. The heart valves and blood flow animation was added, to allow different observation perspectives of the equine heart. A particle animation method was used to demonstrate blood flow and simulate heart valve insufficiencies. The heart valves where modelled with high detail for precise observation. The combination of the heart valve models and the particle animation are accurate simulations of the heart valve disorders. A physiological 3D-model was also added to allow comparison between the pathological and physiological valve movements. Echocardiography is an undeniable, reliable and well established technology and is a standard instrument in today’s veterinary cardiology. To use Echocardiography as a trustworthy instrument. It is necessary to understand the cardiac structures, functions and physiology. In this system, ultrasound sequences are displayed parallel to 3D animation and pictures. The 3D animations show alternative perspectives and are synchronizid to the ultrasound sequences. The third dimension helps to understand the two-dimensional ultrasound view. The user interface allows changes in video speed. On the lower left corner is a scalable picture of the probe's position. The user interface contains a text box. This allows the viewer to read necessary literature without leaving the video page. The sources are added to promote further reading. The most common heart valve insufficiencies and their blood flow disorders where animated to offer the necessary fundamental knowledge. Advisors/Committee Members: m (gender), Prof. Dr. Arthur Grabner i. R. (firstReferee), Univ.-Prof. Dr. Cordula Poulsen Nautrup (furtherReferee), Univ.-Prof. Dr. Johannes Handler (furtherReferee).

Subjects/Keywords: Equidae; cardiovascular disorders; E-learning; heart valves Ultrasonography; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA (6^th Edition):

Tastutar, T. (2015). an educational medium. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5575

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tastutar, Timurhan. “an educational medium.” 2015. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-5575.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tastutar, Timurhan. “an educational medium.” 2015. Web. 30 Mar 2020.

Vancouver:

Tastutar T. an educational medium. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-5575.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tastutar T. an educational medium. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-5575

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

18. Schlieben, Patricia. Impact of Histological Grade and c-kit-Mutations on the Protein Expression Profile of Canine Cutaneous Mast Cell Tumors.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4609

► Cutaneous mast cell tumors (MCT) are one of the most common skin tumors in dogs. According to their histological appearance and the applied grading- system… (more)

▼ Cutaneous mast cell tumors (MCT) are one of the most common skin tumors in dogs. According to their histological appearance and the applied grading- system two or three different histological grades have to be distinguished. Grade 1 or low-grade MCT are characterized by well differentiated monomorphic tumor cells which neither tend to metastasize nor recur. Grade 3 or high-grade MCT are composed of dedifferentiated pleomorphic mast cells which often recur or even metastasize to distant organs. Although mast cell tumors are in the focus of research worldwide molecular details which provide the basis for this different clinical behavior are in most aspects unknown. Studies about KIT, the receptor for stem cell factor, and its proto-oncogene c-kit revealed promising results, as the identification of an activating internal tandem duplication in exon 11 lead to the assumption that KIT activity is of major relevance to MCT proliferation and progression. Impact of c-kit-mutations on the protein expression profile of mutated MCT cells is however unknown. Since recent studies identified c-kit-mutations in only 12 % of all MCT and 40 % of grade 3 MCT, other molecular alterations have to be responsible for the aggressive clinical behavior of grade 3 MCT. Therefore, the present study compared the protein expression patterns of grade 1 and grade 3 MCT (each n=5) and of MCT with or without c-kit-mutation (each n=3) by two-dimensional difference gel electrophoresis. Differentially expressed proteins were identified by mass spectrometry subsequently. Tumors of distinct histological grade differed in the expression of 13 proteins. Most of them are associated with stress resistance, cell motility and mast cell differentiation. Further studies are needed now to evaluate if these modified expressions patterns are responsible for the aggressive clinical behavior of grade 3 MCT. The comparison of c-kit-mutated and non-mutated MCT revealed 15 significantly differentially expressed proteins. Contrary to the second hypothesis no proteins with an association to increased proliferation activity were detectable. These results substantiate the assumption that activating mutations in the proto-oncogene c-kit are of less relevance for clinical behavior than the histological grade. Advisors/Committee Members: w (gender), Prof. Dr. Robert Klopfleisch (firstReferee), PD Dr. Michael Veit (furtherReferee), Univ.-Prof. Dr. Johanna Plendl (furtherReferee).

Subjects/Keywords: Cancer; Canis; mass spectrometry; mast cells; proteomics; tumours; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schlieben, P. (2013). Impact of Histological Grade and c-kit-Mutations on the Protein Expression Profile of Canine Cutaneous Mast Cell Tumors. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schlieben, Patricia. “Impact of Histological Grade and c-kit-Mutations on the Protein Expression Profile of Canine Cutaneous Mast Cell Tumors.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-4609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schlieben, Patricia. “Impact of Histological Grade and c-kit-Mutations on the Protein Expression Profile of Canine Cutaneous Mast Cell Tumors.” 2013. Web. 30 Mar 2020.

Vancouver:

Schlieben P. Impact of Histological Grade and c-kit-Mutations on the Protein Expression Profile of Canine Cutaneous Mast Cell Tumors. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-4609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schlieben P. Impact of Histological Grade and c-kit-Mutations on the Protein Expression Profile of Canine Cutaneous Mast Cell Tumors. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-4609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

19. Reckzeh, Claudia. Immunohistochemical analysis for deposits of scrapie prionprotein in ovine tissues.

Degree: 2011, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9343

► Six goats and 169 sheep carrying the genotype susceptible for PrPSc from a flock naturally infected with classical scrapie were culled and investigated for scrapie… (more)

▼ Six goats and 169 sheep carrying the genotype susceptible for PrPSc from a flock naturally infected with classical scrapie were culled and investigated for scrapie using a rapid test on brainstem material (obex). Forty sheep turned out to be TSE-positive. The remaining 135 animals (with a negative test result in the obex region) were further investigated for the accumulation of PrPSc in selected lymphatic and neuronal tissue samples in order to reveal the actual prevalence in this affected flock and to assess the validity of the brain stem based rapid test result. Furthermore potential ports of entry of the agent and its spread throughout the body as well as the usefulness of certain tissues for an antemortem diagnosis were investigated. The following tissues were investigated immunohistochemically from all 135 animals: ileum, ileocolic lymph node, retropharyngeal lymph node, tonsils and third eyelid. If PrPSc in one of the above mentioned tissues was detected, other tissues were checked for the presence of PrPSc (superficial cervical lymph node, spleen, rectum, solar plexus, ganglion cervicale craniale, ganglion stellatum, vagus nerve and tongue). In another 13 (10 %) out of 129 investigated sheep PrPSc was detected in peripheral tissues. In total, 53 sheep tested positive for PrPSc. That means that 24,5 % (13 sheep) had not been detected using rapid test in the brain stem. Referring to the number of investigated sheep 7,7 % of them were positive. The tissues producing positive results most frequently in this study were the tonsil and the retropharyngeal lymph node each with nine positive results, while ileum, superficial cervical lymph node and spleen were positive in eight sheep respectively. In the solar plexus PrPSc was detected in six sheep which also showed PrPSc in the enteric nervous system of the ileum and three of them also of the rectum. Only two sheep were positive in the third eyelid. All investigated tissues from the six goats tested negative. In conclusion, this study shows that a negative result of the rapid test for brain stem samples does not exclude the presence of PrPSc in peripheral tissues. In consequence, the actual prevalence of scrapie is significantly underestimated when it is only based on brainstem samples. Moreover this study shows that lymphatic tissues such as the retropharyngeal lymph node and the tonsil are meaningful tissues for a closer investigation, if more information about the TSE-state of an animal is of any interest. In all, this study supports possible ports of entry as well as the postulates of a progress of PrPSc from the periphery to the CNS. The results from third eyelid and rectum samples do not support the usefulness of antemortem tests using these tissues. But an investigation of the tonsils provides an opportunity for early diagnosis. Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Reinhard Fries (firstReferee), Prof. Dr. Martin Groschup (furtherReferee), Univ.-Prof. Dr. Michael Schmidt (furtherReferee).

Subjects/Keywords: scrapie; immunohistochemistry; nervous system; lymphatic system; sheep; goats; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reckzeh, C. (2011). Immunohistochemical analysis for deposits of scrapie prionprotein in ovine tissues. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9343

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reckzeh, Claudia. “Immunohistochemical analysis for deposits of scrapie prionprotein in ovine tissues.” 2011. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-9343.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reckzeh, Claudia. “Immunohistochemical analysis for deposits of scrapie prionprotein in ovine tissues.” 2011. Web. 30 Mar 2020.

Vancouver:

Reckzeh C. Immunohistochemical analysis for deposits of scrapie prionprotein in ovine tissues. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-9343.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reckzeh C. Immunohistochemical analysis for deposits of scrapie prionprotein in ovine tissues. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-9343

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

20. Irrgang, Alexandra. Biochemical characterization of antigenic proteins from pathogenic Prototheca species.

Degree: 2016, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8731

► Prototheca spp. are unicellular, saprophytically living algae. Although these microorganisms belong to the phylogenetic group of the green algae, they are colorless due to the… (more)

▼ Prototheca spp. are unicellular, saprophytically living algae. Although these microorganisms belong to the phylogenetic group of the green algae, they are colorless due to the absence of chlorophyll. Therefore their metabolism is characterized as obligate heterotrophic. Macroscopically they bear a likeness to yeasts of the genus Candida but the algae can be differentiated from them easily under the microscope because they show no budding. Prototheca reproduce asexually by the formation of endogenous daughter cells. They are of medical and veterinary interest as some of the Prototheca species are associated with infections in humans and animals, known as protothecosis. They fulfill all qualifications to be highly pathogenic: a strong and resilient cell wall, resistance against physical, chemical and mechanical stress, formation of a resting cell stage and limited treatment options. However, protothecosis is a relatively rare disease. The pathogenic agent, the pathogenicity as well as the localization of the infection vary between the different host species. Protothecosis may occur as local infection for example as cutaneous manifestation but can run a disseminated course. There is little known about the underlying mechanisms of pathogenicity. To lay the basis of understanding the course of infection, the aim of this thesis was to determine immunoreactive proteins of Prototheca zopfii GT2 by western blot analysis and identify those using MALDI TOF MS. In the first part of this work, western blot analysis was used to identify immunodominant protein spots using sera of experimentally infected rabbits. With these 24 immunoreactive proteins of P. zopfii GT2 were detected, from which 15 proteins could be identified by MALDI TOF MS. Most of these proteins were proteins of regulatory functions and enzymes of the metabolism. Some of them - malate dehydrogenase (MDH), heat shock proteins 70 (Hsp70), elongation factor 1-α, (EF-1α) and 14-3-3 protein – are known as immunoreactive proteins from other eukaryotic pathogens. Further crossreactivity of the sera with proteins from P. zopfii GT1 and P. blaschkeae was tested with a high success rate. 48 of these crossreactive proteins could be determined using MALDI TOF MS, too. ATPase, MDH, EF-1α and Hsp70 were identified from western blot analysis of all tested strains. In the second part of this PhD thesis, experiments with sera from naturally infected dogs were performed as above. The canine sera display a marked crossreactivity between different species and genotypes, too. Taken together 198 proteins spots were analyzed by MALDI TOF MS from which 86 were identified. Comparable with the leporine sera, the main part of the immunoreactive proteins obtained with canine infection sera were proteins of regulation, replication, protein expression and metabolic enzymes. It is noticeable that MDH, Hsp70, EF-1α and 14-3-3 protein were also found as immunoreactive proteins. These are involved in pathogenicity of the eukaryotic pathogens Anisakis sp., Schistosoma sp. and Cryptococcus sp.… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Uwe Rösler (firstReferee), Univ.-Prof. Dr. Thomas Alter (furtherReferee), PD Dr. Karsten Nöckler (furtherReferee).

Subjects/Keywords: Prototheca; protothecosis; MALDI-TOF; western blot; antigens; virulence factors; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Irrgang, A. (2016). Biochemical characterization of antigenic proteins from pathogenic Prototheca species. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8731

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Irrgang, Alexandra. “Biochemical characterization of antigenic proteins from pathogenic Prototheca species.” 2016. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-8731.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Irrgang, Alexandra. “Biochemical characterization of antigenic proteins from pathogenic Prototheca species.” 2016. Web. 30 Mar 2020.

Vancouver:

Irrgang A. Biochemical characterization of antigenic proteins from pathogenic Prototheca species. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-8731.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Irrgang A. Biochemical characterization of antigenic proteins from pathogenic Prototheca species. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-8731

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

21. Brünig, Paula. In-vitro and in-vivo studies on the efficacy of various microbial phytases as feed additives.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9622

► Two E.coli phytases (Optiphos and FB-Phytase) were examined regarding their biochemical abilities (pH behaviour, temperature behaviour and –stability as well as proteolytic stability) to validate… (more)

▼ Two E.coli phytases (Optiphos and FB-Phytase) were examined regarding their biochemical abilities (pH behaviour, temperature behaviour and –stability as well as proteolytic stability) to validate their suitability as feed additives. The commercially available Aspergillus phytase Natuphos® has been consulted as the comparing enzyme. The results of the pH behaviour show that the pH optimum of the examined enzymes is located in the acidic range. The optimal pH values of the E.coli phytases are 4.5 and 5.0, whereas Natuphos® shows the best effect at pH 5.5. In the neutral pH range all enzymes are inactive. The temperature optimum for the phytases was determined by incubating the enzymes in a sodium acetate buffer with the optimal pH value for each of the enzymes at eight different temperatures in the range of 30°C to 80°C for 60 minutes. The subsequent determination of the phytase activity showed a temperature optimum at 55°C for both E.coli phytases and an optimal temperature of 50°C for the Aspergillus enzyme. The temperature stability of the phytases was determined for three different temperatures and with a total period of 120 minutes. The enzymes were incubated in sodium acetate buffer with the optimal pH value for each of the enzymes. Afterwards the phytase activity was determined. The measurements of temperature stability in aqueous solution show that Natuphos® ist the most stable of the three examined enzymes, whereas Optiphos is the least stable one. After 20 minutes of incubation at 50°C Optiphos already has a residual phytase activity of less than 10%, however FB-Phytase and Natuphos® exhibit residual activities of 60% and 80% respectively. The phytases were also examined regarding their heat stability during the pelleting process. In this case the Peniophora phytase ZY-Phytase was consulted as the comparing enzyme. The phyases were added to a mixed ration for pigs which was exposed to four different temperatures between 55°C and 85°C while pelletizing. The E.coli enzyme Optiphos (in the granulated form) was the more stable E.coli phytase. At 85°C this enzyme had a residual activity of 77%. The comparing enzyme Peniophora was also stable under these conditions (96% residual activity at 85°C). The FB-Phytase was inactivated at 85°C both in the granulated form and as powder. The powder form of the Optiphos enzyme was also not stable at 85°C. To assay the resistance of the phytases against proteases the enzyme preparations were incubated in an aqueous pepsin- or pancreatin solutionat 40°C. The results show that the comparing enzyme Natuphos® is sensitive to pepsin but even more sensitive to pancreatin. Optiphos lost about 45% of its activity in both media and is therefore only moderately resistant to proteolytic inactivation. FB-Phytase is relatively insensitive towards the pepsin inactivation (about 74% residual activity). The influence of digesta supernatant on the enzymes has been tested as well. The incubations were carried out at 40°C for 60 minutes in a digesta solution from the stomach and proximal jejunum… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Ortwin Simon (firstReferee), Prof. Dr. Rainer Borriss (furtherReferee), Prof. Dr. Karl Heinz Lahrmann (furtherReferee).

Subjects/Keywords: feed additives; enzymes; phytase; in vitro; properties; piglets; efficacy; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brünig, P. (2010). In-vitro and in-vivo studies on the efficacy of various microbial phytases as feed additives. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brünig, Paula. “In-vitro and in-vivo studies on the efficacy of various microbial phytases as feed additives.” 2010. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-9622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brünig, Paula. “In-vitro and in-vivo studies on the efficacy of various microbial phytases as feed additives.” 2010. Web. 30 Mar 2020.

Vancouver:

Brünig P. In-vitro and in-vivo studies on the efficacy of various microbial phytases as feed additives. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-9622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brünig P. In-vitro and in-vivo studies on the efficacy of various microbial phytases as feed additives. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-9622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

22. Kujawa, Anne. Investigations on the specificity and sensitivity of the Thyroid Transcription Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for feline primary lung tumors.

Degree: 2016, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13602

► The incidence of feline primary lung tumors has increased over the last decades. Yet, by comparison, feline lung tumors are poorly examined. Little is known… (more)

▼ The incidence of feline primary lung tumors has increased over the last decades. Yet, by comparison, feline lung tumors are poorly examined. Little is known about correlations between tumor subtypes, tumor cell origin, prognosis and clinical outcome. Currently, feline lung tumors are usually diagnosed based on the classification of the World Health Organization (WHO), which is based solely on histological features. This classification is not only interpreted differently, but also criticized by various authors. A simple and reliable diagnosis is essential for determining the tumor dignity and origin, because feline primary lung tumors are frequently malignant and metastasize in over 75 % of cases. Apart from that, the lung is one of the major centers for metastases, making it difficult to differentiate primary lung tumors only on the basis of histologic criteria. The aim of this study was to investigate the sensitivity and specificity of Thyroid Transcription Factor-1 (TTF-1) and the function of Ki67 as malignancy markers for feline primary lung tumors and to examine, whether they support or facilitate the application of the current WHO classification. For this purpose, 1) the actual applicability of the existing WHO classification was determined, 2) relevant tumor characteristics were acquired, 3) the specificity of TTF-1 for feline lung tumors was examined, 4) correlations between TTF-1 expression levels, the tumor characteristics and tumor dignity were discussed, 5) the expression of the proliferation marker Ki67 was surveyed in the tumors, 6) the diagnostic potential of a combination of TTF-1 and Ki67 was analyzed and 7) the benefit of both markers and their combination for the classification of feline primary lung tumors was tested. According to the histological criteria of the WHO guidelines, 61 feline lung tumors were initially classified. In the process, various features, specific for different tumor subtypes, occurred frequently in the same tumor. Furthermore, the described cell characteristics associated with certain growth patterns (papillary, bronchioloalveolar) differed from the actually occurring tumor cells. The applicability of the tumor classification remained generally very limited, since the feature descriptions were unclear and partly contradictory. In the second part of this thesis, the lung tumor marker TTF-1, already established in human medicine, was examined for its specificity for feline lung tumors. Immunohistochemical stainings confirmed its specificity for feline lung tumors and a relation between its expression and the tumor dignity. The results revealed a positive correlation between the TTF-1 expression and tumor differentiation grade. Since TTF-1 is only expressed in benign but not all malignant lung tumors, its potential as a tumor marker is limited in diagnostic practice. Furthermore, the expression of the proliferation marker Ki67 was also explored in the tumors. As expected, its expression negatively correlated with the degree of differentiation. Thus, the Ki67 expression was… Advisors/Committee Members: [email protected] (contact), w (gender), Univ.-Prof. Dr. Robert Klopfleisch (firstReferee), PD Dr. Sebastian Arlt (furtherReferee), PD Dr. Kerstin Müller (furtherReferee).

Subjects/Keywords: cats; lung cancer; transcription factors; immunohistochemistry; markers; WHO, classification; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kujawa, A. (2016). Investigations on the specificity and sensitivity of the Thyroid Transcription Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for feline primary lung tumors. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13602

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kujawa, Anne. “Investigations on the specificity and sensitivity of the Thyroid Transcription Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for feline primary lung tumors.” 2016. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-13602.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vancouver:

Kujawa A. Investigations on the specificity and sensitivity of the Thyroid Transcription Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for feline primary lung tumors. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-13602.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kujawa A. Investigations on the specificity and sensitivity of the Thyroid Transcription Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for feline primary lung tumors. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-13602

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

23. Bruhnke, Alexandra. Effect of horse shoeing on the perfusion of the corium in the solear margin.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6495

► From the following two phenomena the question arises whether shoeing horses regularly with iron horse shoes and nails may determine a compression of the circumflex… (more)

▼ From the following two phenomena the question arises whether shoeing horses regularly with iron horse shoes and nails may determine a compression of the circumflex artery of the sole and the area it supplies initiated by the direct pressure of the shoeing and thus be the cause for various acute and chronic dysfunctions occurring in hoof shoeing. The first phenomena is the often observed clammy movement of newly shod horses and the second is the detectable extinction of blood vessel patterns in the corium of the hoof when compressed by a hoof examination forceps. From 31 horses with healthy hooves that died or were euthanized at the Equine hospital of the Free University of Berlin, 71 specimens of hooves were obtained. The specimens were divided in three Groups: 28 of the formerly unshod specimens were shod by different techniques (tightly studded, loosely studded, and normally studded but weakened hoof sole), 18 of the specimens were already shod when obtained and left that way and 25 of the formerly unshod stayed unshod as reference group. The circumflex artery of the sole has been displayed by a radiographic contrast agent study of the coffin bone. Subsequently, the angiograms were examined for disruptions of the contrast filling in the circumflex artery of the sole. The results of this study did not reveal a correlation between filling defects at the circumflex artery of the sole and shoeing. Twelve percent (3/25) of the unshod reference group, 5,6% (1/18) of the previously shod and 7,1% (2/28) of the experimentally shod specimen showed at least one disruption of the circumflex artery of the sole. Shoeing horses with iron horse shoes and nails using correct shoeing technique could not produce a compression of the circumflex artery of the sole - even in specimens with thin soles. The experimental assembly did not allow any conclusion as to whether a compression of the circumflex artery of the sole relevant to blood flow could be induced when body weight of the horse and strain of movement are taken into consideration. Furthermore, pathophysiologic mechanism of tissue due to shoeing such as local inflammation triggering contraction of blood vessels and reduction of blood flow could not be observed with this study design. In vivo angiographic studies would be necessary to further evaluate these important questions. Advisors/Committee Members: w (gender), Univ.- Prof. Dr. Christoph Lischer (firstReferee), Univ.-Prof. Dr. Johanna Plendl (furtherReferee), Prof. Dr. a. D. Klaus- Dieter Budras (furtherReferee).

Subjects/Keywords: horses; lameness; hooves; blood vessels; schoeing; orthopaedics; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bruhnke, A. (2015). Effect of horse shoeing on the perfusion of the corium in the solear margin. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6495

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bruhnke, Alexandra. “Effect of horse shoeing on the perfusion of the corium in the solear margin.” 2015. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-6495.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bruhnke, Alexandra. “Effect of horse shoeing on the perfusion of the corium in the solear margin.” 2015. Web. 30 Mar 2020.

Vancouver:

Bruhnke A. Effect of horse shoeing on the perfusion of the corium in the solear margin. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-6495.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bruhnke A. Effect of horse shoeing on the perfusion of the corium in the solear margin. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-6495

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

24. Zauscher, Johanna Maria Martina. Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim Pferd.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8512

► Größenveränderungen des Fesseltrageapparats des Pferdes werden besonders im Bereich des Ursprungs bevorzugt zur Diagnose von Erkrankungen und zur Beurteilung des Heilungsverlaufes durchgeführt, da pathologische Form-… (more)

▼ Größenveränderungen des Fesseltrageapparats des Pferdes werden besonders im Bereich des Ursprungs bevorzugt zur Diagnose von Erkrankungen und zur Beurteilung des Heilungsverlaufes durchgeführt, da pathologische Form- und Strukturveränderungen gerade dort nicht immer sicher von normalen Befunden zu unterscheiden sind. Der individuell sehr unterschiedliche Gehalt an Muskelfasern führt im Bereich des Fesselträgerursprungs und des Fesselträgerkörpers zu einem Ultraschallbild mit variabler Echogenität. Auch verursachen Gefäßanastomosen und überlagernde Sehnen und Bänder Artefakte im Verlauf des gesamten Fesseltrageapparats mit Ausnahme der Fesselträgerschenkel. Ziel der Studie war es, die Präzision von Messungen im Bereich des Ursprungs, des Körpers und der Schenkel des Fesselträgers sowie des geraden und der schrägen Gleichbeinbänder an Vorder- und Hinterbeinen des Pferdes zu untersuchen. Zusätzlich wurden im Bereich des Fesselträgerursprungs verschiedene sonographische Untersuchungstechniken zur Größenmessung evaluiert. 14 gesunde Pferde (sechs Traber, sechs Araber-Mix, ein Warmblut, ein Quarter Horse) im Alter von 5 - 28 Jahren wurden an allen vier Gliedmaßen sonographisch untersucht. Anhand von longitudinalen und transversalen Ultraschallbildern, die mit einer Linearsonde (12 MHz) erstellt wurden, wurde die Tiefe, die Breite, der Umfang und die Fläche an, durch die Anatomie definierten, Stellen gemessen. Im Bereich des Ursprungs wurde auch eine Microconvexsonde (8 MHz) eingesetzt. Ebenfalls im Ursprungsbereich der Vordergliedmaße wurde zusätzlich an der gebeugten Gliedmaße mit einer Linearsonde und einer Microconvexsonde ein Sonogramm erstellt. Zwei Untersucher sonographierten die Tiere je zweimal im Abstand von mindestens einem Tag. Die Scans wurden im Archiv des Ultraschallgerätes gespeichert und dort ausgemessen. Die inter- und intraobserver Variabilität wurde mittels des mean agreement index und 95% limits of agreement (Bland und Altmann 1986) bestimmt. Zu den zuverlässigeren Messungen gehörten im longitudinalen Sonogramm die Messung der Tiefe in den Bereichen des Fesselträgerursprungs und der Fesselträgerschenkel und im transversalen Sonogramm die Messung des Umfangs in den Bereichen der Fesselträgerschenkel und des geraden Gleichbeinbandes in der distalen Fesselbeuge. Alle Messungen im Bereich des Fesselträgerkörpers und der schrägen Gleichbeinbänder hatten eine geringe Reliabilität. Die Zuverlässigkeit der Messungen der Größe im Bereich des Fesseltrageapparats sollten berücksichtigt werden, wenn diese verwendet werden um klinische Entscheidungen zu treffen. Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Christoph Lischer, Dipl. ECVS, Assoc. Dipl. ECVDI Large Animal (firstReferee), Univ.-Prof. Dr. Johannes Handler, Dipl. ECAR (furtherReferee), Prof. Dr. K. D. Budras (furtherReferee).

Subjects/Keywords: horses; ultrasonograpy; ultrasound; limbs; ligaments; repeatability; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zauscher, J. M. M. (2013). Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim Pferd. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8512

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zauscher, Johanna Maria Martina. “Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim Pferd.” 2013. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-8512.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zauscher, Johanna Maria Martina. “Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim Pferd.” 2013. Web. 30 Mar 2020.

Vancouver:

Zauscher JMM. Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim Pferd. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-8512.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zauscher JMM. Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim Pferd. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-8512

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

25. Whelan, Rose. Ein transgenes probiotisches Bakterium als ein Träger für ein immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen Entzündungen.

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13115

► Chronisch-entzündliche Darmerkrankungen (CED) sind Autoimmunerkrankungen, die durch eine ungeregelte Darmentzündung gekennzeichnet werden. Heutige Therapien sind nicht bei allen betroffenen Patienten wirksam und oft mit unerwünschten… (more)

▼ Chronisch-entzündliche Darmerkrankungen (CED) sind Autoimmunerkrankungen, die durch eine ungeregelte Darmentzündung gekennzeichnet werden. Heutige Therapien sind nicht bei allen betroffenen Patienten wirksam und oft mit unerwünschten Nebenwirkungen verbunden. Daher besteht ein dringender Bedarf für die Entwicklung neuer Behandlungsmethoden. Parasitische Nematoden sekretieren immunmodulatorische Moleküle, die es ihnen gestatten, längerfristig im Wirt zu überleben und sich dort fortzupflanzen. Studien mit an CED erkrankten Menschen und experimentell herbeigeführten Darmentzündungen bei Mäusen zeigten, dass die Immunmodulation der Nematoden die Symptome von CED sowohl bei Menschen als auch bei Mäusen abmilderte. Cystatin, welches von der Filarie Acanthocheilonema viteae sekretiert wird (AvCys), wirkt stark entzündungshemmend bei Kontakt mit Immunzellen, vor allem bei Makrophagen. Eine neuartige Behandlung von CED wurde unter Verwendung des probiotischen Bakteriums Escherichia coli Nissle 1917 (EcN) entwickelt. Hierbei werden transgene Bakterien, welche das AvCys Gen exprimieren, in den Wirtsdarm eingebracht um eine anhaltende Applikation des entzündungshemmenden Cystatins direkt vor Ort zu ermöglichen. Der Einsatz der transgenen EcN-AvCys Probiotika bei Mäusen mit akuter Kolitis bewirkte eine deutliche Reduktion der Expression von Chemoattraktanzien, der Einwanderung von Entzündungszellen und der T-Zellantwort im Darm. Dies führte zu einer insgesamt drastisch reduzierten Entzündungsreaktion. Da der Magen-Darmtrakt von Schweinen sehr dem des Menschen ähnelt, wurde die entzündungshemmende Aktivtät von EcN-AvCys daraufhin an einer genetisch diversen Versuchstierpopulation von Hausschweinen getestet. Dabei wurden Ferkeln, die nach der Entwöhnungsphase an einer Darmfehlfunktionen litten, wiederholt hohe Dosen von EcN-AvCys verabreicht. Die Behandlung reduzierte erheblich die Darmentzündungen und stellte überdies kein Risiko für die Körpergewichtsentwicklung und Immunfunktion der Ferkel dar. Um die mechanistische Grundlage für die antiinflammatorische Wirkung von EcN-AvCys zu analysieren, wurde der Phänotyp der Monocyten der Schweine unter verschiedenen Bedingungen untersucht: (1) nach Inkubation mit Überständen aus Zellkulturen von EcN, (2) EcN-AvCys bzw. (3) rekombinantem AvCys. Während rekombinates AvCys sehr wenig Einfluss auf die Expression von Monozyten- Markergenen hatte, induzierten die Überstände von sowohl EcN als auch EcN- AvCys Kulturen gleichsam eine frühe Expression von M1-assoziierten Markern sowie regulatorischem IL-10. Anschließend wurde die Hypothese getestet, dass AvCys die entzündungsfördernden Makrophagen-Funktionen stören könnte indem durch Beeinträchtigung des Inflammasoms die Aktivierung des entzündungsfördernden Zytokins IL-1ß gehemmt wird. Hierzu wurden Monozyten und Makrophagen mit Überständen der transgenen und Kontrollkulturen der probiotischen Bakterien inkubiert, wobei die Sekretion von IL-1ß überwacht wurde. Anstatt die Sekretion von IL-1ß als Reaktion auf die Induktion des Inflammasoms zu… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Susanne Hartmann (firstReferee), Univ.-Prof. Dr. Lothar Wieler (furtherReferee), Prof. Dr. Britta Siegmund (furtherReferee).

Subjects/Keywords: Inflammatory Bowel Disease; probiotics; nematoda; intestinal mucosa; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Whelan, R. (2015). Ein transgenes probiotisches Bakterium als ein Träger für ein immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen Entzündungen. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13115

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Whelan, Rose. “Ein transgenes probiotisches Bakterium als ein Träger für ein immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen Entzündungen.” 2015. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-13115.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Whelan, Rose. “Ein transgenes probiotisches Bakterium als ein Träger für ein immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen Entzündungen.” 2015. Web. 30 Mar 2020.

Vancouver:

Whelan R. Ein transgenes probiotisches Bakterium als ein Träger für ein immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen Entzündungen. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-13115.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Whelan R. Ein transgenes probiotisches Bakterium als ein Träger für ein immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen Entzündungen. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-13115

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

26. Padberg, Wiebke. Efficacy of biological drugs as prophylaxis of endometritis in dairy cows.

Degree: 2011, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4919

► The objective in this study was to evaluate the efficacy of the homotoxicologic drugs Lachesis comp. ad us. vet.®, Carduus comp. ad us. vet.® and… (more)

▼ The objective in this study was to evaluate the efficacy of the homotoxicologic drugs Lachesis comp. ad us. vet.®, Carduus comp. ad us. vet.® and Traumeel® for the prevention of endometritis in dairy cows. The study was conducted as a randomised, controlled and blinded field- trial on a conventional dairy farm in Brandenburg. Two protocols of therapy were compared to a placebo group. A total of 593 animals (404 dairy cows, 189 heifers) were included into this study. The drugs were injected subcutaneously four times at weekly intervals. The first injection was given within 24 hours after calving. The first examination of the study animals was carried out on the day of the last injection (PK 1, 21.- 27. day pp). Uterine involution and ovarian follicular development was monitored by visual inspection, rectal palpation and by ultrasonography. At the same time, blood samples from the coccygeal vein were taken from 291 animals. To determine the resumption of cyclic activity, the concentration of serum progesterone was measured. Also, the concentrations of betahydroxybutyrat (BHBA) and nonesterified fatty acids (NEFA) in blood serum were examined to establish the metabolic status of the animals. If endometritis or deficient ovarian activity was diagnosed, the examination was repeated at PK 2 (28.- 34. day pp) and PK 3 (35.– 41 day pp), respectively. Data from all animals were collected including history of calving, retained placenta and twins. If study animals showed signs of sickness like serious injuries because of calving, displaced abomasum, hypocalcaemia or anomalies of the uterus they were excluded from the study. Animals, which were treated systemically or intrauterine with antibiotics or hormones within 72 days after calving were excluded equally. All results of examination were documented and classified. The interpretation of the results from examinations were made for all animals as well as for cows and heifers. Regarding frequency or severity of endometritis, a positive influence of the homotoxicologic drugs could not be found for any date of examination. Resumption of ovarian activity did not differ significantly between the three study groups as well as the distribution of BHBA- and NEFA- concentration in blood serum. Days to first service, days open, first- service conception rate and conception rate were determinated. The differences between the groups were not significant. The reason for leaving was documented and analyzed for all animals, left the dairy farm within 200 days pp. There were no significant differences between the groups, also. Our data show that the homotoxicologic drugs and protocols of therapy evaluated in this study was not efficacious. Further research is required to investigate the possibilities of a different combination of homotoxicologic drugs or different times of treatment. Advisors/Committee Members: w (gender), Univ.-Prof. Dr. W. Heuwieser (firstReferee), Prof. Dr. Robby Andersson (furtherReferee), PD Dr. Bernd- Alois Tenhagen (furtherReferee).

Subjects/Keywords: Dairy cows; chronic endometritis; Lachesis compositum; Carduus compositum; Traumeel; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Padberg, W. (2011). Efficacy of biological drugs as prophylaxis of endometritis in dairy cows. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4919

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Padberg, Wiebke. “Efficacy of biological drugs as prophylaxis of endometritis in dairy cows.” 2011. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-4919.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Padberg, Wiebke. “Efficacy of biological drugs as prophylaxis of endometritis in dairy cows.” 2011. Web. 30 Mar 2020.

Vancouver:

Padberg W. Efficacy of biological drugs as prophylaxis of endometritis in dairy cows. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-4919.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Padberg W. Efficacy of biological drugs as prophylaxis of endometritis in dairy cows. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-4919

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

27. Rabbani, Imtiaz. Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im Pansenepithel des Schafes.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13532

► Zahlreiche Studien belegen, dass das Pansenepithel sich sowohl in funktioneller, als auch in morphologischer Hinsicht an Veränderungen in der Fütterung anpassen kann. Dieser Prozess kann… (more)

▼ Zahlreiche Studien belegen, dass das Pansenepithel sich sowohl in funktioneller, als auch in morphologischer Hinsicht an Veränderungen in der Fütterung anpassen kann. Dieser Prozess kann Tage oder Wochen dauern; jedoch werden auch kurzfristige tägliche Schwankungen im pH des Pansens beobachtet, welcher insbesondere nach den Mahlzeiten und im Falle von SARA für 3-4 Stunden auf sehr niedrige Werte (<5.5) absinken kann. Diese tägliche Variation im pH Wert und in der Fettsäurekonzentration im Pansen stellt eine starke Belastung für das Pansenepithel dar und protektive Mechanismen sind erforderlich, um diesen akuten Belastungsschüben zu begegnen. Es war daher die Absicht dieser Studie, die Schutzfunktion eines Heat Shock Proteins (Hsp70) und des NHEs an Epithelien des Pansens zu untersuchen, welche auf der mukosalen Seite Veränderungen im pH, in der Konzentration kurzkettiger Fettsäuren, in der Temperatur oder dem osmotischen Druck ausgesetzt worden waren. Um die protektive Funktion dieser Proteine zu untersuchen, wurde der Transport von Na und Azetat über das Pansenepithel in konventionellen Untersuchungen in der Ussingkammer in vitro gemessen. Begleitend wurde an Tieren, bei welchen durch Konzentratfütterung im Pansen SARA-ähnliche Fermentationsbedingungen induziert worden waren, die in vivo Expression von Hsp70 untersucht. Die folgenden Ergebnisse wurden erhalten: 1\. Die Charakterisierung des elektroneutralen Natriumtransportes durch NHE zeigte klar, dass die Isoform NHE3 den elektroneutralen Natriumtransport vermittelt. Applikation des spezifischen NHE3 Blockers S3226 reduzierte Jms Na und Jnet, welche sich danach nicht signifikant vom gleichbleibenden Isc unterschieden. Dieses weist darauf hin, dass S3226 den elektroneutralen Natriumtransport hemmt. 2\. Die Inkubation von isoliertem Pansenepithel in der Ussingkammer unter SARA ähnlichen Bedingungen mit niedrigem pH (6.4-6.0) und/oder hoher Konzentration kurzkettiger Fettsäuren (70-80 mmol·l-1), ansteigender Temperatur oder Zunahme des osmotischen Druckes induzierte eine Überexpression von Hsp70. Diese Expression wurde reduziert wenn die Stressoren ein bestimmtes Maß überschritten. So kam es z.B. bei einer Zunahme der Temperatur >44ºC, einer Konzentration von kurzkettigen Fettsäuren >100 mM und einem Abfall des pHs auf der mukosalen Seite >5.5 zu einem Abfall der Hsp70 Expression. 3\. Die Expression von Hsp70 konnte durch einen nicht-spezifischen (Cycloheximid) oder spezifischen (Triptolid) Inhibitor abgesenkt werden, wodurch weitere Untersuchungen in der Anwesenheit und Abwesenheit von Hsp70 ermöglicht wurden. Cycloheximid war am effektivsten in einer Konzentration von 3.0 mmol·l-1, während Triptolid in einer Konzentration von 100 nmol·l-1 eingesetzt wurde. Unter Kontrollbedingungen hatte der Gebrauch dieser Inhibitoren weder auf den Kurzschlussstrom (Isc) noch auf die Leitfähigkeit (Gt), die Na- oder die Azetatfluxe einen Einfluss. 4\. Der elektroneutrale Transport von Na und der Transport von Azetat waren signifikant höher nach Überexpression von Hsp70. Diese… Advisors/Committee Members: m (gender), Univ.-Prof. Dr. H. Martens (firstReferee), Univ.-Prof. Dr. A. Richter (furtherReferee), Univ.-Prof. Dr. K. E. Müller (furtherReferee).

Subjects/Keywords: rumen; epithelium; ion transport; sodium; heat shock proteins; sheep; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rabbani, I. (2010). Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im Pansenepithel des Schafes. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13532

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rabbani, Imtiaz. “Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im Pansenepithel des Schafes.” 2010. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-13532.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rabbani, Imtiaz. “Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im Pansenepithel des Schafes.” 2010. Web. 30 Mar 2020.

Vancouver:

Rabbani I. Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im Pansenepithel des Schafes. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-13532.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rabbani I. Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im Pansenepithel des Schafes. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-13532

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

28. Hanebeck, Christine. a contribution to the cultural history of pig especially considering the ergot intoxikation.

Degree: 2011, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12619

► As the result of the investigation of the connection between St. Antony “the Great” and the pig is confirmed, that this is not based on… (more)

▼ As the result of the investigation of the connection between St. Antony “the Great” and the pig is confirmed, that this is not based on the historical original person from the 4th century, but rather exclusively it is based on the work of the biggest hospice-order of the Middle Ages, the Antoniter-order. The biography of the historical original person Antony has been come down with the "Vita Antonii" of Athanasius of Alexandria in detail. Important points of the church-political and theological discussions of it`s writing time have slipped in onto this biography of the old- egypt hermit Antony. In this context a traditional teaching speech of St. Antony has to be integrated in which is citing the biblical story about the “Healing of the demented man”, in which is pointed to understanding the pig as an impure animal. Domestic animals, in particular the pig, are picked out as a central theme at no place of “Vita Antonii”. Therefore domestic animals, in particular the pig, can not be associated with historical Antonius. However, the tip on the pig in connection with demonic power refers in general to the jewish and early- christian understanding of the pig as an impure animal. This understanding existed in the old Orient and later in the whole mediterranean area, often beside the traditionally existing esteeming understanding of this for a long time domesticated animal by the hereditary population groups. Till the Middle Ages the disparaging judgement of the pig as an impure animal could keep itself partial, although it had become in many parts of Europe the most important meat supplier for population`s feeding. The connection of St. Antony “the Great” with the pig is to be settled chronologically only in the Middle Ages. The Antoniter-order which originated in 1247 in France and which went out from a charitable active lay brotherhood, developed to the biggest and mightiest hospice-order of the Middle Ages. It refers to St. Antony as the order-patron. The Antoniter-order devoted itself to the care and therapy of people poisoned with ergot and to the care of the recovered people, who often had to live on as a cripple. Within the scope of their activity the Antoniter specialized in the diagnostics and therapy in particular of the gangrenous form of this Intoxikation. They rendered outstanding services to the medieval hospice system, to the development of special therapeutic attempts as well as to the spreading of medical specialist knowledge of their time. To cover the required material basis for it`s work the order set up a highly organized collective system, the "Quest". It became usual that the population -predominantly living in agrarian structures- donated either collectively drawn up battle pigs or piglets to further fatten as natural contributions. Pigs were suitable on account of their quickly growing up and of their uncomplicated breeding (keeping in forest; feeding with food rubbish) particularly for an effective food production. In this connection the Antoniter developed… Advisors/Committee Members: w (gender), Priv.-Doz. Dr. Eberhard Uecker (firstReferee), Univ.-Prof. Dr. Kerstin Müller (furtherReferee), Priv.-Doz. Dr. Rainer Struwe (furtherReferee).

Subjects/Keywords: veterinary history; Claviceps purpurea; ergotism; swine diseases; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hanebeck, C. (2011). a contribution to the cultural history of pig especially considering the ergot intoxikation. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hanebeck, Christine. “a contribution to the cultural history of pig especially considering the ergot intoxikation.” 2011. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-12619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hanebeck, Christine. “a contribution to the cultural history of pig especially considering the ergot intoxikation.” 2011. Web. 30 Mar 2020.

Vancouver:

Hanebeck C. a contribution to the cultural history of pig especially considering the ergot intoxikation. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-12619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hanebeck C. a contribution to the cultural history of pig especially considering the ergot intoxikation. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-12619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

29. Balczulat, Stefanie. Investigations on different genotypes and investigations on the carbohydrate metabolism of Histomonas meleagridis.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9922

► Histomonosis, blackhead disease or infectious typhlohepatitis of the gallinaceous birds is caused by the protozoen parasite or Trichomonad Histomonas meleagridis. The disease is characterized by… (more)

▼ Histomonosis, blackhead disease or infectious typhlohepatitis of the gallinaceous birds is caused by the protozoen parasite or Trichomonad Histomonas meleagridis. The disease is characterized by an inflammation of the ceca and liver damages. The mortality in turkey flocks can reach 90 %. The first part of this thesis included investigations and analysis of different genotypes of H. meleagridis. The first studies were done on 568 samples, which had been send to the Institute for Poultry Diseases and were tested for H. meleagridis using a qPCR. The samples originated from 252 suspected cases of histomonosis of the years 2004 till 2010. Of the 568 samples 209 samples were positive, 357 samples negative and 2 samples questionable. Four hundred seventy three samples were organs including 193 ceca, 190 livers and 42 pools of ceca and liver. 48 samples were different organes like gizzard, rectum, cloaca, spleen, kidney, oesophagus or pancreas. 252 of the organ samples were from turkeys and 176 from chickens. Only 19 samples were from other gallinaceous birds like peacocks, pheasants, snow cocks, guinea fowls and quails and were tested with mostly negative result. The species of 29 samples was unknown. Of 46 samples of invertebrates and 42 samples of the environment only eight and four samples respectively were positive, while 38 each were negative. For genotyping the method of the C-Profiling was modified by designing primers specific for H. meleagridis. One hundred twenty five samples, that were positiv for H. meleagridis, were genotyped. The ITS1-region of this samples was C-profiled. Five different profiles were found (type A through E). Type A was the most frequently detected type in over half the samples. Types B and C were mostly found in turkey samples. Type D occured only in chicken samples and in one peacock sample. Type E was found in only one chicken sample. Furthermore 273 samples were tested for the presence of Blastocystis spp. And Tetratrichomonas gallinarum. There was a significant relationship between the occurrence of histomonosis and the concurrent absence of T. gallinarum. In contrast the relationship between H. meleagridis and Blastocystis ssp. was not significant. The second part of the thesis dealt with investigations on the metabolism of H. meleagridis. Several experiments on the cultivation were done. First the effect of the buffers MOPS and HEPES were tested. With 5, 25 or 100 mmol/L HEPES and with 50 or 100 mmol/L MOPS respectively histomonads grew well. In concentrations of 250 mmol/L MOPS or HEPES no histomonal growth was observed. In the following experiments the influence of different starch sources and carbohydrates instead of rice powder were tested. Starch sources were potato starch, amylose, amylopectin and glycogen. Only potato starch supported histomonal growth. The carbohydrates glucose, pyruvate, glucose-1-phosphat, glucose-6-phosphat and maltose were tested in different concentrations with or without the addition of rice. Cultures without rice survived at best. Often they died. Growth… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Hafez Mohamed Hafez (firstReferee), Univ.-Prof. Dr. Georg von Samson-Himmelstjerna (furtherReferee), Prof. Dr. Peter-Henning Clausen (furtherReferee).

Subjects/Keywords: Histomonas meleagridis; genotypes; polymerase chain reaction; Galliformes; carbohydrate metabolism; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Balczulat, S. (2014). Investigations on different genotypes and investigations on the carbohydrate metabolism of Histomonas meleagridis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9922

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Balczulat, Stefanie. “Investigations on different genotypes and investigations on the carbohydrate metabolism of Histomonas meleagridis.” 2014. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-9922.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Balczulat, Stefanie. “Investigations on different genotypes and investigations on the carbohydrate metabolism of Histomonas meleagridis.” 2014. Web. 30 Mar 2020.

Vancouver:

Balczulat S. Investigations on different genotypes and investigations on the carbohydrate metabolism of Histomonas meleagridis. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-9922.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Balczulat S. Investigations on different genotypes and investigations on the carbohydrate metabolism of Histomonas meleagridis. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-9922

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

30. Hellauer, Andrea Karin. Effect of different head-neck-positions on endoscopic findings of the upper airway tract and on stress associated parameters in the ridden horse.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8715

► In recent years one can observe more and more frequently the use of hyperflexion, the so-called "rollkur" at ridden horses in education, training, but also… (more)

▼ In recent years one can observe more and more frequently the use of hyperflexion, the so-called "rollkur" at ridden horses in education, training, but also in competitions. The aim of this study was on the one hand, in a preliminary study, to test the applicability of the overground endoscopy under natural training conditions and on the other hand, in the main study, to investigate the effects of different head-neck-positions on endoscopic findings of the upper respiratory tract and stress parameters in the ridden horse. In the preliminary study a total of 30 horses of different types of use were examined. One-third were each gallop racing horses, trotters and riding horses. The horses were investigated in their natural environment under real training conditions with the overground endoscope. The behaviour during the application of the equipment and during the investigation was documented and the endoscopic images were recorded. Later, these were evaluated with regard to their picture quality and ease of interpretation. Overall, the study was very well practicable in most horses. Four horses showed strong defensive movements during insertion of the endoscope and in three of these horses the investigation had to be cancelled. The remaining horses were all trainable with the inserted endoscope, only one horse has shown slight head shaking during exercise. Two horses have developed slight nosebleeds during investigation. The quality of images was high enough to evaluate findings of the upper respiratory tract. The preliminary investigation has revealed that the new technique of overground endoscopy is an available option to examine horses under natural training conditions endoscopically. The application has been practicable in the field and most of the horses have tolerated the investigation. Furthermore goal of the present study was a comparison between the impacts of different head-neck-positions on findings in the upper respiratory tract of ridden horses. For this purpose video recordings of the larynx of 14 horses were recorded using the above mentioned overground endoscope. The videos were recorded at rest and during three different riding phases: first at stretching posture, secondly at a working head-neck-position and thirdly at hyperflexion. In comparison between the phases working head- neck-position and hyperflexion the analysis revealed a significant reduction of the laryngeal opening area (p = 0.001) with a value of 8.2 ± 5.0%. Beyond that, other evaluated parameters of the larynx, except its height, showed a significant diminishment as well. These changes did not correlate with the age of the horses or their level of education and they were independent of the individual anatomic conditions of the head-neck region. Capitulatory it can be stated that hyperflexion has caused a considerable compression of the larynx. In the present study the influence of different head-neck-positions on stress parameters were investigated, too. In 18 horses heart rate, heart rate variability (HRV) and blood cortisol levels were… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Heidrun Gehlen (firstReferee), Prof. Dr. Corinna Eule (furtherReferee), Univ.-Prof. Dr. Rudolf Staufenbiel (furtherReferee).

Subjects/Keywords: respiratory system; horses; physiology; exercise; endoscopy; stress; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hellauer, A. K. (2014). Effect of different head-neck-positions on endoscopic findings of the upper airway tract and on stress associated parameters in the ridden horse. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8715

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hellauer, Andrea Karin. “Effect of different head-neck-positions on endoscopic findings of the upper airway tract and on stress associated parameters in the ridden horse.” 2014. Thesis, Freie Universität Berlin. Accessed March 30, 2020. http://dx.doi.org/10.17169/refubium-8715.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hellauer, Andrea Karin. “Effect of different head-neck-positions on endoscopic findings of the upper airway tract and on stress associated parameters in the ridden horse.” 2014. Web. 30 Mar 2020.

Vancouver:

Hellauer AK. Effect of different head-neck-positions on endoscopic findings of the upper airway tract and on stress associated parameters in the ridden horse. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2020 Mar 30]. Available from: http://dx.doi.org/10.17169/refubium-8715.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hellauer AK. Effect of different head-neck-positions on endoscopic findings of the upper airway tract and on stress associated parameters in the ridden horse. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-8715

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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