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Freie Universität Berlin
1.
Roth, Swaantje Juliane.
Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen
Populationsgebieten.
Degree: 2012, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-4766
► Phocines Herpesvirus 1 (PhHV-1) gehört als großes, doppelsträngiges DNA Virus der Familie Herpesviridae, Subfamilie Herpesvirinae, Genus Varicellovirus an. Erstmals isoliert und partiell charakterisiert wurde das…
(more)
▼ Phocines Herpesvirus 1 (PhHV-1) gehört als großes, doppelsträngiges DNA Virus
der Familie Herpesviridae, Subfamilie Herpesvirinae, Genus Varicellovirus an.
Erstmals isoliert
und partiell charakterisiert wurde das Virus bei erkrankten
jungen Seehunden (Phoca vitulina) in der Nordsee. PhHV-1 ist weltweit
verbreitet
und Erkankungen sind assoziiert mit hoher Morbidität
und
Mortalität. Virusisolate von Tieren im Antlantik / in europäischen Gewässern
differieren genetisch von Isolaten von Robben aus dem Pazifik
und auch
postmortale Befunde bei erkrankten Tieren sind unterschiedlicher Ausprägung.
Während Pneumonie
und hepatische Nekrosen das pathologische Bild in mit
europäischen Isolaten infizierten Robben dominieren, sind adrenale Nekrosen
ein charakteristischer Hauptbefund in pazifischen Robbenarten. Nur wenige
Studien berichten bisher über PhHV-1 Seroprävalenzen in wild lebenden Robben,
die meisten davon über Tiere der nördlichen Hemisphäre. Insbesondere bei
Tieren in Zoos
und Aquarien werden häufig bilaterale Augenerkrankungen
unbekannter Ätiologie diagnostiziert. Die Symptomatik ist auch, jedoch
seltener, bei wild lebenden Tieren bekannt. Da die Reaktivierung von felinem
Herpesvirus 1 (FeHV-1) in Katzen eine sehr ähnliche Symptomatik verursacht,
wurde die Hypothese aufgestellt, dass PhHV-1 an der Ätiologie von
Augenerkrankungen in Robben beteiligt ist. Ein PhHV-1 spezifischer
quantitative-Echtzeit-PCR (qPCR) Assay, basierend auf Alignments bekannter
PhHV-1 Glycoprotein B Sequenzen, wurde entwickelt, um Augen-, Nasen-
und
Genitaltupferproben frei lebender Seehunde, Sattelrobben (Phoca groenlandica)
und Klappmützenrobben (Crystophora crystata) aus der Arktis
und Seebären
(Arctocephalus gazella), Weddellrobben (Leptonychotes weddellii),
und See-
Elefanten (Mirounga leonida) aus der Antarktis auf PhHV-1 DNA zu untersuchen.
Die erstmalige Detektion von PhHV-1 DNA in Genitaltupferproben wirft die Frage
auf, inwiefern das Virus, ähnlich bovinen oder equinen Herpesviren, in
Reproduktionsprobleme involviert sein könnte. Ein indirekter PhHV- 1 ELISA
wurde entwickelt
und Seehunde der Arktis sowie Seebären, Weddellrobbe,
Krabbenfresser (Lobodon carcinophaga), Rossrobben (Ommatophoca rossii)
und
See- Elefanten der Antarktis wurden serologisch getestet. Serumproben von
Seehunden über einen Zeitraum von 12 Jahren ermöglichten die Beobachtung
dieser Population hinsichtlich PhHV-1 Seroprävalenzen über längere Zeit.
Erstmals konnten Antikörper auch in Rossrobben
und See-Elefanten festgestellt
werden, was indiziert, dass diese Spezies empfänglich für PhHV-1 sind.
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Nikolaus Osterrieder (firstReferee), Prof. Dr. Alex Greenwood (furtherReferee), Prof. Dr. Morten Tryland (furtherReferee).
Subjects/Keywords: Herpesviridae; seals; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Roth, S. J. (2012). Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen
Populationsgebieten. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4766
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Roth, Swaantje Juliane. “Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen
Populationsgebieten.” 2012. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-4766.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Roth, Swaantje Juliane. “Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen
Populationsgebieten.” 2012. Web. 22 Apr 2021.
Vancouver:
Roth SJ. Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen
Populationsgebieten. [Internet] [Thesis]. Freie Universität Berlin; 2012. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-4766.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Roth SJ. Nachweis von phocinem Herpesvirus 1 in Robben in unterschiedlichen
Populationsgebieten. [Thesis]. Freie Universität Berlin; 2012. Available from: http://dx.doi.org/10.17169/refubium-4766
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
2.
Fischer-Tenhagen, Carola.
Using snifferdogs for diagnosing in animal reproduction.
Degree: 2019, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-26592
► Diese Habilitationsschrift befasst sich mit Untersuchungen zum Einsatz des Geruchs als Indikator physiologischer und pathologischer Prozesse. Als Beispiele dieser Anwendung in der veterinärmedizinischen Reproduktionsmedizin dienen…
(more)
▼ Diese Habilitationsschrift befasst sich mit Untersuchungen zum Einsatz des Geruchs als Indikator physiologischer
und pathologischer Prozesse. Als Beispiele dieser Anwendung in der veterinärmedizinischen Reproduktionsmedizin dienen die Bestimmung physiologischer Zustände am Beispiel der Brunst bei der Milchkuh
und die Erkennung von Erkrankungen am Beispiel der bovinen Mastitis. Als weiteres Beispiel aus dem medizinischen Bereich dient die Suche nach Biomarkern für Krebserkrankungen des Menschen. Die Geruchshunde werden in den Arbeiten genutzt, um das Vorhandensein spezifischer Gerüche der obengenannten Zustände oder Prozesse darzustellen. Dabei werden die Ergebnisse der eigenen Arbeiten zu diesem Thema kritisch hinterfragt, evaluiert
und mit den Studienergebnissen anderer Autorinnen
und Autoren in Beziehung gesetzt.
Einleitend werden wissenschaftliche Erkenntnisse zum Geruch
und zum Geruchssinn zusammenfassend dargestellt. Anschließend wird die Bedeutung von Geruch als Symptom von Krankheiten in der
Medizin früher
und heute beschrieben.
Die überdurchschnittliche Riechleistung
und gute Trainierbarkeit des Hundes wird seit der Domestikation zur Unterstützung des Menschen bei der Jagd, aber auch zur Suche von gefährlichen oder illegalen Substanzen genutzt (Helton, 2009). Neben den klassischen Aufgaben der Menschen-, Sprengstoff-
und Drogensuche werden Hunde auch eingesetzt um Schädlinge (Holzkäfer, Bettwanzen), Schimmel in Gebäuden oder Krankheiten des Menschen (Krebs, Diabetes) zu identifizieren (Browne et al., 2006).
Im Rahmen dieser Arbeit wurden verschiedene Studien mit Geruchshunden in der Reproduktionsmedizin durchgeführt. Unter anderem werden Arbeiten zur Brunsterkennung beim Rind durch spezifische Gerüche
und die Erkennung von Infektionen der Milchdrüse durch Staphylococcus aureus beschrieben.
In den letzten 20 Jahren mehren sich Arbeiten zu diesen Themen mit wissenschaftlichem Anspruch. Die Evidenz dieser Arbeiten wird beurteilt
und Herausforderungen
und Limitierungen für wissenschaftliches Arbeiten mit Geruchshunden dargestellt. Insbesondere die Konzeption von objektiven Testverfahren für die Überprüfung der Geruchsleistung der Hunde bringt große Herausforderungen mit sich, die hier diskutiert werden. Nach kritischer Betrachtung werden Empfehlungen für einen bestmöglichen Testaufbau für Geruchstests mit Hunden gegeben.
Advisors/Committee Members: female (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: Suchhund; Brunsterkennung; Geruchsdetektion; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fischer-Tenhagen, C. (2019). Using snifferdogs for diagnosing in animal reproduction. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-26592
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fischer-Tenhagen, Carola. “Using snifferdogs for diagnosing in animal reproduction.” 2019. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-26592.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fischer-Tenhagen, Carola. “Using snifferdogs for diagnosing in animal reproduction.” 2019. Web. 22 Apr 2021.
Vancouver:
Fischer-Tenhagen C. Using snifferdogs for diagnosing in animal reproduction. [Internet] [Thesis]. Freie Universität Berlin; 2019. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-26592.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fischer-Tenhagen C. Using snifferdogs for diagnosing in animal reproduction. [Thesis]. Freie Universität Berlin; 2019. Available from: http://dx.doi.org/10.17169/refubium-26592
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
3.
Wallstab, Almut.
Influence of three organ preservation solutions (HTK solution,
Baeyer-2-solution, HTK solution with added iloprost) on the renal function in
a model of isolated hemoperfused porcine kidney.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-5822
► The composition of an organ preservation solution has a major influence on the functional quality of transplanted organs. Therefore in this study the influence of…
(more)
▼ The composition of an organ preservation solution has a major influence on the
functional quality of transplanted organs. Therefore in this study the
influence of iloprost added to a common organ preservation solution on the
renal function was examined. Iloprost, being an analogue of prostacyclin, has
got vasodilatory and profibrinolytic effects and inhibits platelet
aggregation. For this purpose a model of isolated hemoperfused porcine kidney
established by v. Baeyer and Grosse-Siestrup was used. 18 kidneys of german
landrace pigs were hypothermically preserved over a period of 2 hours after
which they were perfused with autologous blood. Three different organ
preservation solutions were used for the purpose of hypothermical
preservation: HTK solution (group I), Baeyer-2-solution (group II) and HTK
solution with added iloprost (group III). Each group contained 6 kidneys which
were hemoperfused over a period of 180 minutes. Blood and urin samples were
taken every 30 minutes to evaluate renal function using the following
parameters: sodium, blood gases, hemoglobin, creatinine, glucose, total
protein, osmolality. Blood pressure as well as flow rate of blood and
dialysate were measured. The following parameters were then calculated: renal
resistance, creatinine clearance, sodium reabsorption, tubular sodium
transport, oxygen consumption, diuresis, ratios of urine / plasma osmolality,
protein, creatinine and glucose. The values after 60, 120 and 180 minutes were
used for statistical analysis. Regarding hemodynamic parameters kidneys of
group II and III performed significantly better than those of group I. Blood
flow rate after 180 minutes perfusion was 250ml/min*100g in group II and III
whereas group I showed 136 ml/min*100g. Renal resistance after 180 minutes
perfusion was 0,30 mmHg*min*100g/ml in group II, 0,35 mmHg*min*100g/ml in
group III and 0,66 mmHg*min*100g/ml in group I. Hence the addition of iloprost
significantly improved renal hemodynamics in group III compared to group I and
proved to be similar effective as group II. Concerning functional parameters
oxygen consumption stood out showing significant differences. Oxygen
consumption in group III was significantly higher at all measurements compared
to group I as well as after 60 and 120 minutes compared to group II (medians
after 60/120/180 minutes: group I 139/112/117, group II 103/98/82, group III
203/171/165 (mol/min*100g). A possible reason could be less damage of
functional nephrons and therefore better renal vitality in group III.
Accordingly one would expect an increased tubular sodium transport which was
the case in group III compared to group I. However, no significant differences
were apparent among the three groups. Therefore an improved functionality
could not be proven. Adding iloprost to HTK solution improves the preservation
quality to some extent and seems to be similar effective as Baeyer-2-solution.
Advisors/Committee Members: w (gender), PD Dr. Christian Große-Siestrup (firstReferee), Prof. Dr. Dr. David Groneberg (furtherReferee).
Subjects/Keywords: Prof. Dr. Karl Heinz Lahrmann; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wallstab, A. (2013). Influence of three organ preservation solutions (HTK solution,
Baeyer-2-solution, HTK solution with added iloprost) on the renal function in
a model of isolated hemoperfused porcine kidney. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5822
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wallstab, Almut. “Influence of three organ preservation solutions (HTK solution,
Baeyer-2-solution, HTK solution with added iloprost) on the renal function in
a model of isolated hemoperfused porcine kidney.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-5822.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wallstab, Almut. “Influence of three organ preservation solutions (HTK solution,
Baeyer-2-solution, HTK solution with added iloprost) on the renal function in
a model of isolated hemoperfused porcine kidney.” 2013. Web. 22 Apr 2021.
Vancouver:
Wallstab A. Influence of three organ preservation solutions (HTK solution,
Baeyer-2-solution, HTK solution with added iloprost) on the renal function in
a model of isolated hemoperfused porcine kidney. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-5822.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wallstab A. Influence of three organ preservation solutions (HTK solution,
Baeyer-2-solution, HTK solution with added iloprost) on the renal function in
a model of isolated hemoperfused porcine kidney. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-5822
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
4.
Maksimov, Pavlo.
Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii
infections in humans and cats from Germany.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-10766
► Several studies reported that certain T. gondii genotypes and clonal lineages correlate with severe toxoplasmosis in mice and humans. Therefore it may be important to…
(more)
▼ Several studies reported that certain T. gondii genotypes and clonal lineages
correlate with severe toxoplasmosis in mice and humans. Therefore it may be
important to have information on the prevalence of different T. gondii
genotypes in humans and animals. In future, this information may help to
better estimate the risk of infection for humans and animals. Information on
the genotype of T. gondii an individual human or animal is infected may allow
to conclude on the further development of disease and to optimise treatment.
The results of studies summarized in this cumulative thesis demonstrate that a
peptidemicroarray assay can be used for diagnosis of T. gondii infection and
to detect T. gondii clonal type-specific antibody responses in seropositive
humans and cats. With a peptide microarray and sera from experimentally-
infected and naturally-infected cats it was shown for the first time that cats
are able to mount a clonal type-specific IgG antibody response against T.
gondii. After validation, 27 peptides were selected which were suitable for T.
gondii serotyping in cats. Previous work suggested that individuals in the
study area were mainly exposed to T. gondii clonal type II. However, there was
no information, which clonal type of T. gondii is most prevalent in infected
humans, and there was only limited data about the distribution of T. gondii
types in cats in Germany. The results of this study demonstrate that positive
peptide reactions presenting clonal type II were statistically significantly
overrepresented in the tested human and cat population. The intensity, by
which type II peptides were recognized, was also significantly higher than the
intensity with which peptides of other specificities were detected. The
results suggest that most T. gondii infections in humans and cats were caused
by T. gondii clonal type II in Germany and confirmed previous findings
reporting a pre-dominance of type II in oocysts shed by cats in Germany. Since
sporulated T. gondii oocysts present one of the most important sources of
infection for intermediate hosts, it was expected that there were no major
differences in serotyping results between those for cats and humans. These are
the first peptide microarray-based serotyping studies on T. gondii infections
in humans in Germany and the first in cats worldwide. However, further
carefully validated typespecific peptides are necessary to optimize the
specificity of serotyping. Further validation with a larger number of well-
characterized sera may help to identify and select further polymorphic
peptides with a diagnostic potential. The results summarized in the present
thesis (publication 2, manuscript 3) demonstrate that propensity scale-based
and ABCpred bioinformatic methods are suitable for the in-silico prediction of
linear epitopes on T. gondii antigens. The propensity scale method identified
nine polymorphic epitopes that could be used as part of a peptide panel for T.
gondii serotyping in cats. Using ABCpred, eight novel linear epitopes were
predicted, which could be…
Advisors/Committee Members: m (gender), Prof. Dr. Franz Josef Conraths (firstReferee), PD Dr. Jürgen Krücken (furtherReferee), Univ.-Prof. Dr. Thomas Alter (furtherReferee).
Subjects/Keywords: Toxoplasma gondii; immunodiagnosis; classification; peptides; cats; man; Germany; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Maksimov, P. (2013). Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii
infections in humans and cats from Germany. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10766
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Maksimov, Pavlo. “Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii
infections in humans and cats from Germany.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-10766.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Maksimov, Pavlo. “Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii
infections in humans and cats from Germany.” 2013. Web. 22 Apr 2021.
Vancouver:
Maksimov P. Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii
infections in humans and cats from Germany. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-10766.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Maksimov P. Peptide-microarray-based serological diagnosis and typing of Toxoplasma gondii
infections in humans and cats from Germany. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-10766
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
5.
Falk, Anika.
Measurement of the orbital cavity of dogs and cats in order to allow
calculation of intraorbital prosthesis for implantation after enucleation.
Degree: 2017, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-6177
► To agree to enucleation of one or both eyes is one of the largest (emotional) challenges for the patient’s owner in comparison to all surgeries…
(more)
▼ To agree to enucleation of one or both eyes is one of the largest (emotional)
challenges for the patient’s owner in comparison to all surgeries done in
small animal medicine. The owner often gives higher priority to the cosmetic
aspect than to the curative treatment of his pet. For this reason various
options for the replacement of the missing volume of the globe were analyzed
and developed. Nevertheless a perfect orbital substitute is not yet found.
This problem was the reason to determine the dimensions of the orbit in dogs
and cats in this study. Therefore, after the development of a suitable
measurement method in preliminary work, computer tomographic images (Siemens
Light Speed QXi, GE Medical Systems, Milwaukee WI, USA) of 40 dogs (1.4 to
16.6 years, 36 different breeds, 17 female, 23 male, 1.7-72.0 kg) and 40 cats
(1-16 years, 13 breeds, 15 female, 25 male, 2.3-11.9 kg) were retrospectively
evaluated. All dogs (13 brachycephalic, 22 mesaticephalic, 3 dolichocephalic)
and cats (9 brachycephalic, 26 mesaticephalic, 5 dolichocephalic) were graded
according to their head conformation. For the first time, sections of
measurement for the reasonable and reproducible scales of the total bony orbit
were elaborated. With the help of the program Eclipse (Varian Medical Systems,
Inc., Düsseldorf) orbital structures were defined, volumes were calculated and
the orbit was quantified in height, width and depth. Special attention was
focused on the relation between the extension of the orbit and head shape
respectively body height. Measuring the orbital height, only in dogs moderate
differences were found concerning head conformation (p=0.160). In cats the
orbital height is not influenced by the head conformation (p=0.707). There
were significant differences in the width of the orbit in brachycephalic dogs
(p<0.001) that are mainly influenced by a decreased Proc. frontalis of the Os
zygomaticum. Moreover the orbital width of the different head conformations in
cats showed significant differences (p=0.008). The results of the presented
study did not confirm the previously suggested theory of brachycephalic
animals possessing a flat orbit and dolichocephalic animals having a deep
orbit (mean dogs: 3.45 cm brachycephalic, 3.39 cm mesaticephalic, 3.22 cm
dolichocephalic; mean cats: 2.89 cm brachycephalic, 2.79 cm mesaticephalic,
2.55 cm dolichocephalic). Moreover anatomic characteristics in brachycephalics
cats are the reason for this appearance. In brachycephalic dogs the formation
of the Proc. frontalis is rather responsible for the position of the globe
within the orbit and is providing the appearance of a protruding globe. In
cats the appearance of a planar orbit is promoted through the shortening of
the nasal bones, but does not stand in correlation to the orbital size.
Nevertheless a significant influence of the body weight onto the extension of
the orbit in dogs (p<0.001) and cats (p<0.001) could be proven. With
increasing body weight the size of the orbital space rises. The extension of
the orbit is positively correlated…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Corinna Eule (firstReferee), Univ.-Prof. Dr. Johanna Plendl (furtherReferee), Univ.-Prof. Dr. Christoph Lischer (furtherReferee).
Subjects/Keywords: cats; dogs; orbits; amputation; skull; measurement; prosthesis implantation; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Falk, A. (2017). Measurement of the orbital cavity of dogs and cats in order to allow
calculation of intraorbital prosthesis for implantation after enucleation. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6177
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Falk, Anika. “Measurement of the orbital cavity of dogs and cats in order to allow
calculation of intraorbital prosthesis for implantation after enucleation.” 2017. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-6177.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Falk, Anika. “Measurement of the orbital cavity of dogs and cats in order to allow
calculation of intraorbital prosthesis for implantation after enucleation.” 2017. Web. 22 Apr 2021.
Vancouver:
Falk A. Measurement of the orbital cavity of dogs and cats in order to allow
calculation of intraorbital prosthesis for implantation after enucleation. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-6177.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Falk A. Measurement of the orbital cavity of dogs and cats in order to allow
calculation of intraorbital prosthesis for implantation after enucleation. [Thesis]. Freie Universität Berlin; 2017. Available from: http://dx.doi.org/10.17169/refubium-6177
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
6.
Reinartz, Marion.
Impact of the deep freezing process and frozen storage on the microflora of
four commercial frozen food products.
Degree: 2012, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-9442
► The aim of this study was to answer the question whether the way of industrial freezing and storing of food products leads to significant reductions…
(more)
▼ The aim of this study was to answer the question whether the way of industrial
freezing and storing of food products leads to significant reductions in the
count of microorganisms. Therefor quantitative microbiological examinations of
five samples per month from each of four frozen food products (“leak, sliced”,
“mushrooms, sliced”, “Maultaschen-Gemüse- Pfanne”, “Stroganoff-Pfanne”) were
conducted. The two raw vegetable products were also examined in the unfrozen
status before the freezing process. With quantitative microbiological
examinations of the products before the freezing process and monthly
examinations during the frozen storage, information about the impact of the
freezing process, the temperature and the storage time (with regard of type of
product and its preprocessing) on the activity of the microorganisms was
collected. Furthermore conclusions about the mortality and survival rate of
the different bacteria species could be drawn. Each of the examined food
belonged to one lot which was produced in December 2007. After the production,
the food packages were stored at constant temperature of -24°C for one year at
a frozen food company and sent monthly to our institute. The quantitative
microbiological examination was conducted by drop plating for the following
microorganisms: Aerobic mesophilic total bacteria, lactic acid bacteria,
lactobacilli, coagulase-positive staphylococci, enterococci, Listeria
monocytogenes, Bacillus cereus, sulfite-reducing anaerobe sporeforming
bacteria, aeromonads, pseudomonads, Enterobacteriaceae, coliforms, E. coli,
yeasts and molds. The reduction of the microbial count after the freezing
process was between 0.30 and 2.25 log10 cfu/g. In the product “leak, sliced”
significant reductions of the bacterial count for all included microorganisms
were noticed while this was observed for only four types of bacteria in the
product “mushrooms, sliced”. According to this, a matrix effect on the
microorganisms during the freezing process can be expected. The one-year
frozen storage caused for certain groups of bacteria a significant reduction
in cell counts which were strongest for Enterobacteriaceae and coliforms.
Lactic acid bacteria, lactobacilli, pseudomonads, yeasts and molds were much
less susceptible. In our experiments the enterococci showed nearly the same
correlation between counts and storing time as the coliforms. Hence, the
information from literature that enterococci are better hygiene indicators for
frozen food products than coliforms cannot be confirmed. If adding the impact
of the freezing process and frozen storage over one year, the microbial
reduction will not be enough to cause a complete decontamination. All
microorganisms present at the beginning were still detectable at the end of
the study. Listeria monocytogenes, coagulase-positive staphylococci,
aeromonads, Bacillus cereus and sulfite-reducing anaerobe spore-forming
bacteria could not be found in any sample or the number of these
microorganisms was below the detection limit of 2.30 log10/1.00 log10 cfu/g.
Beyond…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Goetz Hildebrandt (firstReferee), Univ.-Prof. Dr. Uwe Rösler (furtherReferee), Univ.-Prof. Dr. Reinhard Fries (furtherReferee).
Subjects/Keywords: Microorganisms; bacterial count; freezing; frozen foods; frozen storage; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Reinartz, M. (2012). Impact of the deep freezing process and frozen storage on the microflora of
four commercial frozen food products. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9442
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Reinartz, Marion. “Impact of the deep freezing process and frozen storage on the microflora of
four commercial frozen food products.” 2012. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-9442.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Reinartz, Marion. “Impact of the deep freezing process and frozen storage on the microflora of
four commercial frozen food products.” 2012. Web. 22 Apr 2021.
Vancouver:
Reinartz M. Impact of the deep freezing process and frozen storage on the microflora of
four commercial frozen food products. [Internet] [Thesis]. Freie Universität Berlin; 2012. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-9442.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Reinartz M. Impact of the deep freezing process and frozen storage on the microflora of
four commercial frozen food products. [Thesis]. Freie Universität Berlin; 2012. Available from: http://dx.doi.org/10.17169/refubium-9442
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
7.
Hanke, Christine.
Comparative studies of empty and with osteoinductive materials filled titanium
cages for the cervical spine fusion applied to the animal model sheep.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-4629
► In the course of the treatment of inflammatory and degenerative disc diseases, fractures and tumors of the vertebrae, the intervertebral spondylodesis gained more and more…
(more)
▼ In the course of the treatment of inflammatory and degenerative disc diseases,
fractures and tumors of the vertebrae, the intervertebral spondylodesis gained
more and more clinical relevance in the last years. This therapy is aimed at a
stable vertebral fusion. For decades, the tricortical iliac crest bone graft
was considered as golden standard for interbody fusion of the cervical spine.
The necessary biopsy of autologous material, however, often results in a
significant morbidity among the patients. Subsidence, collapse or migration of
the implant occur as well. This might result in kyphotic deformity or
nonunion. These complications require a development of alternative
intervertebral disc implants. The goal of this study was a radiological
examination of the spondylodesis using an interbody titan-cage for stabilizing
the intervertebral space. This implant was filled with four different
concentrations of modified parathyroid hormone TGplPTH1-34 (0.2 mg/ml, 0.4
mg/ml, 0.7 mg/ml, 1.0 mg/ml). Three groups were used for monitoring: a group
with an empty cage, a group implanted with cancellous bone graft and a group
with fibrin. For this purpose fifty-six adult female merino-mix sheep
underwent discectomy of segment C3/C4. Each monitoring group consisted of
eight animals. After standing for twelve weeks, the animals were euthanized
and the vertebrae C3 and C4 were removed. Utilizing the plain X-ray images
that were taken preoperatively, postoperatively, after 8 weeks and post mortem
after twelve weeks, the disc space height and the intervertebral angle were
determined. The CT images for the subsequent bone density measurements were
performed on the isolated cervical vertebrae. Based on the plain X-ray images
and CT scans a fusion score was defined which describes the status of fusion
after the twelve weeks. For the most part the radiological evaluation of all
collected parameters showed significant differences between the monitoring
groups. However, it was not possible to conclude a clear statement on the
basis of radiographic data, because no group consistently dominated. There
were crucial differences in the results of the groups in terms of the various
examinations. In comparison to the monitoring group “empty cage” and “fibrin”
the levels of PTH-groups were more promising and should be aligned with the
results of histomorphology, histomorphometry and biomechanics.
Advisors/Committee Members: w (gender), PD Dr. Christian Große-Siestrup (firstReferee), Univ.-Prof. Dr. Johanna Plendl (furtherReferee), Prof. Dr. Georg Bergmann (furtherReferee).
Subjects/Keywords: animal models; fibrin; intervertebral discs; parathyrin; radiography; sheep; spine; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hanke, C. (2013). Comparative studies of empty and with osteoinductive materials filled titanium
cages for the cervical spine fusion applied to the animal model sheep. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4629
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hanke, Christine. “Comparative studies of empty and with osteoinductive materials filled titanium
cages for the cervical spine fusion applied to the animal model sheep.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-4629.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hanke, Christine. “Comparative studies of empty and with osteoinductive materials filled titanium
cages for the cervical spine fusion applied to the animal model sheep.” 2013. Web. 22 Apr 2021.
Vancouver:
Hanke C. Comparative studies of empty and with osteoinductive materials filled titanium
cages for the cervical spine fusion applied to the animal model sheep. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-4629.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hanke C. Comparative studies of empty and with osteoinductive materials filled titanium
cages for the cervical spine fusion applied to the animal model sheep. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-4629
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
8.
Haimerl, Peggy.
Ein evidenzbasierter Ansatz.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-6661
► Entscheidungsfindungen in der täglichen tierärztlichen Praxis und Wissenschaft sowie durch Mitarbeiter landwirtschaftlicher Betriebe sollten stets auf objektiven Informationen basieren. Deshalb gewinnt die Anwendung der Evidenzbasierten…
(more)
▼ Entscheidungsfindungen in der täglichen tierärztlichen Praxis
und Wissenschaft
sowie durch Mitarbeiter landwirtschaftlicher Betriebe sollten stets auf
objektiven Informationen basieren. Deshalb gewinnt die Anwendung der
Evidenzbasierten
Medizin zunehmend an Bedeutung. Allerdings sehen wir in der
Veterinärmedizin einen Mangel an gründlich
und systematisch durchgeführten
groß angelegten klinischen Studien, was wiederum einen Mangel an
Forschungsergebnissen hoher Evidenz nach sich zieht. Zusätzlich beobachtet man
eine enorme Variation hinsichtlich der Qualität veterinärmedizinischer
Studien. Daher basiert der Wissenszuwachs im veterinärmedizinischen Bereich
v.a. auf Erfahrungsberichten anstatt auf randomisierten, kontrollierten
klinischen Studien. Randomisierte, kontrollierte, doppelt verblindete Studien
stellen jedoch den Goldstandard bezüglich der Beurteilung einer bestimmten
Behandlungsstrategie dar. Postpartale Gebärmutterentzündungen stellen mit
einer Prävalenz von bis zu 57,7% eine häufige Störung bei der Milchkuh dar.
Diese verursachen aufgrund von beträchtlichen negativen Auswirkungen auf die
Folgefruchtbarkeit hohe Zusatzkosten für die Landwirte. Daher war es das
übergreifende Ziel der durchgeführten Studien, den Status Quo hinsichtlich der
Evidenz der verfügbaren Literatur sowie der Anwendung bzw. der Umsetzung der
Evidenzbasierten Veterinärmedizin (EBVM) einmal näher zu beleuchten. In einer
ersten Studie wurde die Qualität
und Vergleichbarkeit der verfügbaren
Literatur zum Thema Behandlung der bovinen Endometritis mit PGF2α ausgewertet.
Dafür wurden mithilfe einer umfassenden, systematischen Literaturrecherche in
Online Datenbanken bzw. Suchmaschinen 2723 Referenzen zu der untersuchten
Thematik gefunden. Nach Anwendung spezifischer Ausschlusskriterien verblieben
68 Studien für eine weitere Auswertung. Diese Artikel wurden mithilfe eines
speziellen Bewertungsbogens hinsichtlich spezifischer Parameter, wie z.B. dem
Vorhandensein einer Kontrollgruppe sowie der Zuordnung zu den einzelnen
Gruppen, beurteilt. Diese Auswertung zeigte, dass mehr als die Hälfte der
Studien (51,5%) älter als 20 Jahre waren. Zusätzlich zeigte sich, dass etwa
ein Drittel (36,8%) der untersuchten Studien kontrolliert
und randomisiert
waren, während 3 dieser Studien (4,4%) zusätzliche verblindet durchgeführt
worden waren. Zusammenfassend lässt sich sagen, dass die Forschungsergebnisse
hinsichtlich der Wirksamkeit von PGF2α sehr unterschiedlich sind. Aufbauend
auf die erste Studie zielte die zweite Studie auf die quantitative
metaanalytische Bewertung der Behandlung der chronischen Endometritis der Kuh
mittels PGF2α ab. Nach der Anwendung spezifischer Ausschlusskriterien
und der
Bewertung der verbliebenen Studien hinsichtlich bestimmter Evidenzparameter
konnten 5 Publikationen, welche insgesamt 6 Studien umfassten, in die
Metaanalyse eingeschlossen werden. Die Extraktion
und Auswertung der
Studiendaten erfolgte unter Verwendung des Review Managers 5.1. Dabei wurden
mithilfe dieser Software Effektgrößen bezüglich der Auswirkung einer PGF2α…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Wolfgang Heuwieser (firstReferee), Univ.-Prof. Dr. Holger Martens (furtherReferee), Univ.-Prof. Dr. Heidrun Fink (furtherReferee).
Subjects/Keywords: cows; dairy cattle; puerperium; endometritis; treatment; prostaglandins; meta-analysis; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Haimerl, P. (2013). Ein evidenzbasierter Ansatz. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6661
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Haimerl, Peggy. “Ein evidenzbasierter Ansatz.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-6661.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Haimerl, Peggy. “Ein evidenzbasierter Ansatz.” 2013. Web. 22 Apr 2021.
Vancouver:
Haimerl P. Ein evidenzbasierter Ansatz. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-6661.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Haimerl P. Ein evidenzbasierter Ansatz. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-6661
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
9.
Gerling, Corinna.
Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring.
Degree: 2018, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-41
► Even today Trakehners have a special position in German horse breeding, as this breed is the oldest breed of riding horse in Germany. Since the…
(more)
▼ Even today Trakehners have a special position in German horse breeding, as this breed is the oldest breed of riding horse in Germany. Since the beginning of the breeding history of Trakehners, these horses were bred as noble riding and driving horses, whereby the type, stamina and performance capabilities were determined by English and Arabian Thoroughbreds. A rebreeding from heavy warmbloods, which were used in agriculture, to noble light riding horses never happened, because Trakehners were always recruited for the cavalry as light riding and driving horses. Due to the massive introduction of Thoroughbreds, the horses were too light and passed through several strengthening periods. Following World War II only a few breeding horses were available for the reintroduction of breeding. Through the establishment of the Eastern Block, subpopulations could be formed, which were also bred in the former Soviet Union according to pure breeding criteria.
In order to preserve their special genetic structure the breeding methods of pure breeding were retained up to the present day. All further warmblood breeding associations bred with variably open stud books. By pure breeding the special genetic structure can be maintained but the small population necessitates good organization in order to maintain the incest rate at the lowest possible level. The special conditions of pure breeding enable an inclusion of genes from English and Arabian Thoroughbreds, as well as Shagya Arabians and Anglo-Arabians and pure-bred Trakehners from abroad. This enlargement of the gene pool has a traditional foundation, enlarges the variance and reduces the incest rate. Nowadays, Trakehners are bred worldwide. Several daughter associations have been formed for supporting foreign breeders.
For this investigation the performance characteristics of the actively breeding mare population from the year 2014 were examined in correlation to the special blood contingent of the mares. Using a pedigree analysis the mares were subdivided into five groups with respect to increasing proportions of their special blood contingent in the first two generations. Special blood was defined as ancestors of the breeds English Thoroughbred, Arabian Thoroughbred, Shagya Arabians, Anglo-Arabians and horses from the foreign subpopulation. In total the central data from the Trakehner Zuchtverband (Trakehner Breeding Association) and the FN (German Riding Association) from 9915 horses were evaluated. In the first part of the evaluation it could be shown that more than one third of actively breeding registered mares had a special blood contingent of 25% and more. A high level of special blood has therefore also been established in the previous generations.
In the second part the performance-related data of the mares and their offspring were analyzed. The performance data investigated are selection criteria in the breeding program. Data from the foal registration, stud book entries, mare performance tests and tournaments were included. Stallion performance tests and licensing…
Advisors/Committee Members: female (gender), Handler, Johannes (firstReferee), Gehlen, Heidrun (furtherReferee), Staufenbiel, Rudolf (furtherReferee).
Subjects/Keywords: horses; Trakehner; animal breeding; blood; pedigree; breeding value; studbooks; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gerling, C. (2018). Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-41
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gerling, Corinna. “Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring.” 2018. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-41.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gerling, Corinna. “Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring.” 2018. Web. 22 Apr 2021.
Vancouver:
Gerling C. Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-41.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gerling C. Proportion and influence of special blood on the Trakehner population of actively breeding mares in 2014 and their offspring. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-41
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
10.
Mücke, Ines.
Evaluation of follicular development, occurence of ovulation and time of
ovulation after progesterone and PGF2α.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-10729
► The aim of this study was to evaluate the influence of the estrous cycle stage at the beginning of treatment with a progesterone releasing intravaginally…
(more)
▼ The aim of this study was to evaluate the influence of the estrous cycle stage
at the beginning of treatment with a progesterone releasing intravaginally
device (PRID), with and without estradiol (PRIDα), and PGF2α. To determine the
effect of the treatment, different parameters were evaluated including
follicle growth and serum steroid concentrations. In addition, the intervalls
between insert removal and LH-surge and insert removal and ovulation were
measured. Finally, the efficacy of this treatment regime was evaluated in view
of synchrony of ovulations and a successful single fixed-timed insemination.
In experiment I six Fleckvieh heifers per group were treated with the PRID
insert on day ¾ (group 1), day 11/12 (group 2) or day 17/18 (group 3) of the
cycle. After 9 days the PRID was removed and PGF2α was administered. In
experiment II heifers were used as in experiment I (group 4 – 6), but the PRID
was used without the estradiol capsule (PRIDα). In all groups blood samples
were taken at the beginning, during and after the treatment to assess the
serum progesterone concentrations. After this treatment the blood estradiol
concentrations were determined. Ultrasonography was used for ovary diagnostic
on day 1, 4, 7 and 10 of the experiment to determine the presence or absence
of follicles and corpora lutea. In order to detect the LH-surge, serum samples
were taken in all groups every two hours starting 40 h after insert removal
until the diagnosis of ovulation could be reached via ultrasonography, which
was carried out every six hours starting 66 h after insert removal. Seven days
following the estrous a blood sample to assess progesterone levels was taken.
In experiment III eightteen heifers were treated irrespectively of their stage
of cycle with PRIDα and PGF2α. 50 h after removal of PRIDα, GnRH was injected
intramuscularly and after 13 h artificial insemination was performed. Blood
samples to assess progesterone levels were taken as in experiment I and II. In
order to detect the LH-surge serum samples were taken 40 h after removal of
the PRIDα until two hours after the GnRH-application. Ovary ultrasonography
was performed 72 h after insert removal to determine the onset of ovulation.
The succes of conception was tested by flushing the ipsilateral uterus horn on
day seven of the cycle. There was no significant difference between the number
of succesfully induced estrous in experiment I (83.3 % PRID) and experiment II
(88.8 % PRIDα). The numbers of follicles >10 mm at the start of treatment were
smaller for heifers in group 1 compared with heifers in group 2 or 3. There
was no difference regarding the numbers of follicles >10 mm between groups 4 –
6. At day four of the treatment heifers in group 1 had a significant smaller
number of follicles >10 mm than at day 7 and 10. In group 2, the number of
follicles >10 mm were smaller on day 7 compared to day 10. In group 5, the
number of follicles was significant higher on day 7 than on day 1. The
comparison of the number of follicles >10 mm between the treatments with…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. med. vet. W. Heuwieser (firstReferee), Prof. Dr. rer. nat. habil. Klaus-Peter Brüssow (furtherReferee), Univ.-Prof. Dr. med. vet. A. Sobiraj (furtherReferee).
Subjects/Keywords: progesterone; heifers; follicles; ovulation; LH; estradiol; prostaglandins; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mücke, I. (2013). Evaluation of follicular development, occurence of ovulation and time of
ovulation after progesterone and PGF2α. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10729
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mücke, Ines. “Evaluation of follicular development, occurence of ovulation and time of
ovulation after progesterone and PGF2α.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-10729.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mücke, Ines. “Evaluation of follicular development, occurence of ovulation and time of
ovulation after progesterone and PGF2α.” 2013. Web. 22 Apr 2021.
Vancouver:
Mücke I. Evaluation of follicular development, occurence of ovulation and time of
ovulation after progesterone and PGF2α. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-10729.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mücke I. Evaluation of follicular development, occurence of ovulation and time of
ovulation after progesterone and PGF2α. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-10729
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
11.
Drumm, Niklas Julius.
Factors influencing pregnancy in thoroughbred mares following colic surgery.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-14483
► Colic surgery in the pregnant broodmare raises concerns not only for the mare, but also for a prospective foal. Previous studies investigated abortion/foaling rates following…
(more)
▼ Colic surgery in the pregnant broodmare raises concerns not only for the mare,
but also for a prospective foal. Previous studies investigated
abortion/foaling rates following medical and surgical management of colic in
pregnant mares. Foaling rates for pregnant mares following colic surgery were
found to be 53.8 to 80% (BOENING and LEENDERTSE, 1993; CHENIER and WHITEHEAD,
2009; SANTSCHI et al., 1991). Conclusions were inconsistent between these
studies regarding the influence of duration of anesthesia, signs of
endotoxemia, and intraoperative hypotension or hypoxemia. The purpose of this
study was to determine the influence of gestational age on foaling rates of
pregnant Thoroughbred mares following colic surgery and to evaluate
potentially influencing perioperative factors. The medical records of
Thoroughbred mares, which had colic surgery performed from 1993 through 2007
at the Rood and Riddle Equine Hospital in Lexington, Kentucky, USA, were
reviewed. Mares that were considered to be pregnant during the colic surgery,
survived to hospital discharge and were registered with the North American
Jockey Club were included. Age of the mare, date of surgery, gestational age,
duration of colic at admission, packed cell volume at admission, surgical
diagnosis, duration of anesthesia, intraoperative hypotension, intraoperative
hypoxemia, surgeon and administration of gestagens and polymixin B were
recorded. Additionally, physical examinations recorded within 72 hours post
surgery were reviewed for signs of postoperative endotoxemia: fever (rectal
temperature of ≥37.6°C), el evated heart rate (>48/min), leucopenia (white
blood cell count of <5000/l) and diarrhea. Information regarding foaling
after surgery, the season before the surgery and the season after the surgery
was obtained from the North American Jockey Club, Lexington, Kentucky, USA.
Mares were considered to have had live foals, if the foals were registered
with the North American Jockey Club. Odds ratios with 95%-confidence limits
were calculated to estimate the effects of the various factors on the foaling
rate. For mares determined pregnant prior to admission (>15 days of
gestation), 152 of 228 (66.7%) had a live foal after colic surgery.
Gestational age at the time of surgery affected foaling rate significantly.
Mares pregnant for 16-39 days at surgery had a lower foaling rate compared
with mares pregnant for ≥40 days: 48.7 (19/39) vs. 69.8% (118/169) (OR=0.41
[0.20, 0.83], P = 0.012). Other factors influencing foaling rate were mares
age (P = 0.001) and duration of colic before surgery (P = 0.03). There was a
trend for duration of anesthesia (P = 0.06), intraoperative hypotension (P =
0.07) and surgeon (0.06) to affect foaling rate. There was no significant
influence on foaling rate detected for packed cell volume prior to surgery,
surgical diagnosis, intraoperative hypoxia, postoperative signs of endotoxemia
and administration of polymixin B. Foaling rate in the season before surgery
was 76.8% and in the season after surgery 59.2%. There was no statistical…
Advisors/Committee Members: m (gender), Univ.-Prof. Dr. Johannes Handler (firstReferee), Univ.-Prof. Dr. Rudolf Staufenbiel (furtherReferee), Univ.-Prof. Dr. Leo Brunnberg (furtherReferee).
Subjects/Keywords: Colic; mares; foaling rate; laparotomy; pregnancy; retrospective studies; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Drumm, N. J. (2013). Factors influencing pregnancy in thoroughbred mares following colic surgery. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14483
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Drumm, Niklas Julius. “Factors influencing pregnancy in thoroughbred mares following colic surgery.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-14483.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Drumm, Niklas Julius. “Factors influencing pregnancy in thoroughbred mares following colic surgery.” 2013. Web. 22 Apr 2021.
Vancouver:
Drumm NJ. Factors influencing pregnancy in thoroughbred mares following colic surgery. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-14483.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Drumm NJ. Factors influencing pregnancy in thoroughbred mares following colic surgery. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-14483
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
12.
Biedermann, Melanie.
Evaluation of new methods for local tumor therapy in a VX2 rabbit model.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-12262
► In many cases, only advanced stage colorectal cancer is diagnosed. At this point, it has often already metastasised to the liver. In these cases, not…
(more)
▼ In many cases, only advanced stage colorectal cancer is diagnosed. At this
point, it has often already metastasised to the liver. In these cases, not
only the patient’s primary tumor, but also metastases have to be treated. For
the treatment of both liver metastases and primary tumors there are local
procedures to be offered. The objective of this project was to investigate new
methods of local therapy of liver tumors/ metastases, which can be used either
as neoadjuvant, adjuvant or stand-alone treatment. It was the aim of this
study to investigate minimally invasive local tumor therapy using a low dose
of drugs. The study on efficacy and tolerance of this method was conducted in
20 rabbits with implanted VX2 liver tumors. The initial idea was to allow
local percutaneous treatment of tumors with therapeutically active substances
delivered by drug-coated balloon catheters. In this way, a large tissue
surface area will be attained by the increased surface of the balloon through
its expansion. In addition, the coating will be sustainably pressed into the
tumor tissue. After that, the active substance should be slowly dissolved in
the tissue or slowly washed away from its location. The following cytostatics
were selected: paclitaxel, arsenic trioxide, 5-fluorouracil, fantolon,
bortezomib, doxorubicin and mitoxanthrone. In addition, the drugs were
compared with appropriate drug-free controls. The above mentioned substances
were tested in vitro for their cytotoxicity against the VX2 tumor cells in
culture. The cells were exposed to any substance at four different
concentrations (2-32 μmol/l for paclitaxel, arsenic oxide, fantolon,
5-fluorouracil and mitoxanthrone, 10- 25 μmol/l for doxorubicin, 0.1-0.4
μmol/l for bortezomib) for 24, 48 and 72 hours. As a control, tumor cells were
incubated without drugs. The total remaining intramitochondrial dehydrogenase
activity as a measure of the cellular vitality compared to the control was the
lowest for doxorubicin with 12 3% (16 μmol/l after 72 h incubation) and the
highest for arsenic trioxide with 52 4% (15 μmol/l after 48 h) when the lowest
value was selected for each substance. All tested substances were shown to be
effective, and their selection for the investigation in the animal study was
based on their physicochemical properties and mechanism of action, as well as
on the experience with these substances in previous studies for other
indications. Not all test substances selected in this study were shown to be
suitable for the coating of balloon catheters, thereby limiting this method of
administration in the in vivo experiments. For that reason another mode of
administration of these substances had to be chosen. Arsenic trioxide and
doxorubicin were injected directly into the tumor using a syringe (four
animals per group). Four rabbits were used for each drug to be tested. The
applied doses were between 1.57 to 1.78 mg for paclitaxel, 11.5 to 22.0 mg for
arsenic trioxide, 1.12 to 1.16 for fantolon and 5.94 to 20.78 for doxorubicin.
In the course of the study the doses for…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Johanna Plendl (firstReferee), Univ.-Prof. Dr. Matthias Taupitz (furtherReferee), Univ.-Prof. Dr. Robert Klopfleisch (furtherReferee).
Subjects/Keywords: rabbits; therapy; tumours; catheters; injection; cytotoxic compounds; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Biedermann, M. (2013). Evaluation of new methods for local tumor therapy in a VX2 rabbit model. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12262
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Biedermann, Melanie. “Evaluation of new methods for local tumor therapy in a VX2 rabbit model.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-12262.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Biedermann, Melanie. “Evaluation of new methods for local tumor therapy in a VX2 rabbit model.” 2013. Web. 22 Apr 2021.
Vancouver:
Biedermann M. Evaluation of new methods for local tumor therapy in a VX2 rabbit model. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-12262.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Biedermann M. Evaluation of new methods for local tumor therapy in a VX2 rabbit model. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-12262
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
13.
Stubbe, Angela geb. Rohder.
Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR
by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh
poultry and minced beef sold in retail markets in Berlin.
Degree: 2011, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-6443
► The objective of this study was to reassess the alternatives for the detection of Arcobacter spp. in fresh meat and to collect data on the…
(more)
▼ The objective of this study was to reassess the alternatives for the detection
of Arcobacter spp. in fresh meat and to collect data on the prevalence of
contamination in fresh chicken thighs and minced beef, using microbiological
and molecular biological methods. Additionally samples of meat from
conventional husbandry were compared to those from organic husbandry. For
microbiological analysis the methods by JOHNSON & MURANO and the multiplex PCR
by HARMON &WESLEY; were applied. Presumptive Arcobacter colonies were
macroscopically, biochemically (catalyse-test, oxidase-test) and
microscopically tested for Gram-stain and motility and subsequently underwent
PCR-reaction by HARMON and WESLEY (1997). In preliminary trials the overall
status of the two foodstuffs and the recovery rate of highly contaminated
samples were examined. Because of its high tenacity Arcobacter butzleri proved
suitable for the preparation of positive control samples. Taken the
preliminary and main trials together, Arcobacter spp. was isolated from 3 out
of 75 (4 %) samples of minced beef. In contrast, 39 out of 103 samples of
poultry were contaminated with Arcobacter spp. (38 %). Chicken samples
originating from conventional husbandry were more often affected than those
from organic husbandry (44 % vs. 25 %). Microbiological findings in suspicious
samples were confirmed by PCR. The combination of both methods (selective
media by JOHNSON and MURANO and PCR by HARMON and WESLEY) can be recommended
for the detection of a contamination with Arcobacter spp.
Advisors/Committee Members: w (gender), Prof. Dr. Goetz Hildebrandt (firstReferee), Univ.-Prof. Dr. Thomas Alter (furtherReferee), Univ.-Prof. Dr. Dr. Hafez Mohamed Hafez (furtherReferee).
Subjects/Keywords: Arcobacter; food contamination; poultry meat; beef; isolation; identification; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Stubbe, A. g. R. (2011). Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR
by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh
poultry and minced beef sold in retail markets in Berlin. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6443
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stubbe, Angela geb Rohder. “Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR
by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh
poultry and minced beef sold in retail markets in Berlin.” 2011. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-6443.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stubbe, Angela geb Rohder. “Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR
by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh
poultry and minced beef sold in retail markets in Berlin.” 2011. Web. 22 Apr 2021.
Vancouver:
Stubbe AgR. Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR
by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh
poultry and minced beef sold in retail markets in Berlin. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-6443.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stubbe AgR. Using the microbiological analysis by JOHNSON & MURANO and the multiplex PCR
by HARMON &WESLEY; for the identification of Arcobacter spp. in fresh
poultry and minced beef sold in retail markets in Berlin. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-6443
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
14.
Sanguankiat, Arsooth.
Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer
Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand.
Degree: 2014, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-7636
► Diese Untersuchung erfolgte innerhalb eines größeren Vorhabens vom Dezember 2004 bis Mai 2005 in Chiang Mai und der Provinz Lamphun in Nord- Thailand. 193 Schlachtschweine…
(more)
▼ Diese Untersuchung erfolgte innerhalb eines größeren Vorhabens vom Dezember
2004 bis Mai 2005 in Chiang Mai
und der Provinz Lamphun in Nord- Thailand. 193
Schlachtschweine (22 unterschiedliche Mastgruppen) wurden individuell bereits
in der Herkunft beprobt
und bis in den Schlachtbetrieb hinein individuell
verfolgt. Die Probenahme erfolgte weiterhin auf individueller Basis über die
Schlachtung
und Bearbeitung, Zerlegung, Transport
und Verkauf. Hierfür standen
1.000 Isolate zur Verfügung. Die Gesamtprävalenz von Salmonella in allen
Proben lag bei 48,9 % (971 von 1982 Proben). Tränkwasser
und Wasser zur
Reinigung lagen beide bei 13,6 %. Schmutzwasser war fast vollständig
Salmonella- positiv (95,5 %), ebenso wie die eingesetzten Sockenproben (94,8
%). Im Schlachtbetrieb
und Schlachtgruppen- bezogen, wurde der höchste
Prozentsatz positiver Proben in der Zerlegung mit 23 % gefunden.
Einzeltierbezogen wurde die niedrigste Quote mit 12,9 % nach dem Abwaschen der
Tierkörper erzielt. Zwischen den Fäkalproben nach dem Transport
und den
Mesenterial-Lymphknotenproben war der Unterschied nur gering (61,4 %
und 63,9
%). Nach dem Spalten der Tierkörper war die Prävalenz ca. 2,5 mal höher als
nach dem Waschen. Der Caecum-Inhalt erbrachte die höchste Prävalenz (83,1 %).
Die Nachweisrate war abhängig von der Probenahmestelle
und der Sendung. Der
höchste Korrelationskoeffizient fand sich zwischen den Positionen, nach dem
Waschen“
und „Frischfleisch nach dem Zerlegen“ (rs = 0,66; P = 0,0014), was
auf Zusammenhänge zwischen den Positionen hindeutet. Das Relative Risiko war
hier signifikant (1,64; 95% CI: 1,294 – 2,089). Der Nachweis von Salmonellen
nach dem Waschen erhöhte die Wahrscheinlichkeit (OR = 3,9; P = 0,039), daß
auch Frischfleisch nach dem Zerlegen Salmonella- positiv war. Die
Wahrscheinlichkeit positiver Proben nach dem Transport erhöhte sich, wenn auch
die Zerlege-Unterlagen positiv waren (OR = 3,9; P = 0,042), auch, wenn die
Sockenproben bereits positiv waren (OR = 5,5; P = 0,01). Der Nachweis in den
Mesenterial- Lymphknoten erhöhte die Wahrscheinlichkeit des Nachweises von
positivem Caecal-Inhalt (OR = 2,3; P = 0,045)
und von positivem Frischfleisch
nach dem Zerlegen (OR = 2,0; P = 0,03). Insgesamt wurden 26 Serovaren
identifiziert. Salmonella Rissen war vorherrschend mit 45,9 % der Isolate. 7
Serovaren (S. Anatum, Krefeld, Panama, Rissen, Stanley, Typhimurium
und
Weltevreden) wurden entlang der gesamten Kette nachgewiesen (Farm,
Schlachtbetrieb, Vertrieb), darunter die am häufigsten nachgewiesenen
Serovaren (S. Rissen, Typhimurium, Stanley). 11 Serovaren (S. Afula, Agona,
Alfort, Bovismorbificans, Chittagong, Corvallis, Derby, Hato, Israel,
Langensalza, Regent
und Rideau) wurden nur in Farm- Proben einschließlich der
Faeces der Tiere nach dem Transport nachgewiesen. 3 Serovaren (S. Eppendorf,
Livingstone
und Tsevie) wurden nur aus Proben im Schlachtbetrieb, eine Serovar
(S. Enteritidis) wurde nur aus dem Vertrieb
und nur aus einer Probe isoliert.
Die Dendrogramme der PFGE („Pulsotypen“) von S. Krefeld, S. Panama
und S.…
Advisors/Committee Members: m (gender), Univ.-Prof. Dr. Reinhard Fries (firstReferee), Univ.-Prof. Dr. Lothar H. Wieler (furtherReferee), Univ.-Prof. Dr. Uwe Rösler (furtherReferee).
Subjects/Keywords: pigs; pork; Thailand; Salmonella; serovars; pulsed-field electrophoresis; typing; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sanguankiat, A. (2014). Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer
Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7636
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sanguankiat, Arsooth. “Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer
Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand.” 2014. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-7636.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sanguankiat, Arsooth. “Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer
Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand.” 2014. Web. 22 Apr 2021.
Vancouver:
Sanguankiat A. Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer
Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-7636.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sanguankiat A. Molekulare Epidemiologie und Serodiversität von Salmonella enterica in einer
Schweineproduktionskette „from Farm to Fork“ in Nord- Thailand. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-7636
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
15.
Suppan, Lilian.
MR-guided high-intensity focused ultrasound for renal sympathetic denervation
– a feasibility study in pigs.
Degree: 2015, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-5021
► Hypertension is one of the most common medical conditions amongst people in developed countries, and it can have fatal consequences for the cardiovascular system. Most…
(more)
▼ Hypertension is one of the most common medical conditions amongst people in
developed countries, and it can have fatal consequences for the cardiovascular
system. Most patients suffer from resistant hypertension and cannot be treated
by common antihypertensive drugs. Recent findings have shown that overactivity
of the sympathetic nervous system plays an important role in the development
of hypertension. This has lead scientists to explore and develop new minimal
invasive treatment methods to degenerate renal sympathetic nerve fibres
located around the renal arteries, thereby preventing this overactivity. One
established method is catheter-based radiofrequency ablation. An endovascular
catheter is inserted in the femoral artery in the inguinal region and pushed
forward to the renal artery. Radiofrequency energy is then applied to the
adventitia of the renal artery. However, this approach is unavailable to
patients who have certain anatomic characteristics. This has therefore led us
to search for new, non-invasive treatment methods for renal denervation.
Magnetic resonance-guided, high-intensity focused ultrasound (MRg HIFUS) is a
non-invasive, ablative method that is currently used primarily for the
treatment of uterine fibroids. We therefore undertook this study to evaluate
the safety and efficacy of MR-guided high-intensity focused ultrasound for
renal sympathetic denervation in a porcine model. A total of ten pigs were
used in this study, one of which was a sham pig and was not treated. During
the MRg HIFUS intervention all pigs were placed under general anaesthesia
using propofol. They were then treated with MRg HIFUS along the right renal
artery. Two of the pigs were sacrificed straight after the MRg HIFUS
treatment, the other eight pigs were sacrificed 28 days later. Both kidneys
were removed and homogenized using formic acid. Samples of the kidneys were
then examined for their concentration of norepinephrine using high pressure
liquid chromatography and electrochemical detection. Renal arteries and
urethras were preserved in formalin, histologically processed, and stained
with HE and EvG staining. Degenerative sympathetic nerve fibres could be
easily detected after this staining. In three of the nine pigs perivascular
oedema indicating thermal tissue damage was diagnosed on the T2w FSE sequences
taken after the HIFUS treatment. Furthermore, the norepinephrine
concentrations in the treated kidneys of the pigs did not drop significantly,
something that would also have indicated the treatment was successful. During
the histological examination, perineural fibrosis, indicating degenerated
sympathetic nerve fibres, was visible in one of the pigs. All pigs tolerated
the treatment very well and there were no serious complications. Three of the
nine pigs treated displayed superficial skin burns following the MRg HIFUS
treatment. The results showed that pigs are not suitable subjects for MRg
HIFUS treatment as a result of long lumbar transverse processes and a dominant
fascia thoracolumbalis. Nine pigs treated with MRg…
Advisors/Committee Members: w (gender), Univ.- Prof. Dr. Johannes Handler (firstReferee), PD Dr. Florian Streitparth (furtherReferee), Univ.- Prof. Dr. Robert Klopfleisch (furtherReferee).
Subjects/Keywords: pigs; animal models; hypertension; ultrasound; magnetic resonance imaging; ultrasonics; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Suppan, L. (2015). MR-guided high-intensity focused ultrasound for renal sympathetic denervation
– a feasibility study in pigs. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5021
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Suppan, Lilian. “MR-guided high-intensity focused ultrasound for renal sympathetic denervation
– a feasibility study in pigs.” 2015. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-5021.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Suppan, Lilian. “MR-guided high-intensity focused ultrasound for renal sympathetic denervation
– a feasibility study in pigs.” 2015. Web. 22 Apr 2021.
Vancouver:
Suppan L. MR-guided high-intensity focused ultrasound for renal sympathetic denervation
– a feasibility study in pigs. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-5021.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Suppan L. MR-guided high-intensity focused ultrasound for renal sympathetic denervation
– a feasibility study in pigs. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-5021
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
16.
Kreausukon, Khwanchai.
Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und
Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und
Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL
produzierende E. coli).
Degree: 2011, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-11495
► Das Ziel der Studie war, Informationen über den Einsatz von Antibiotika in deutschen Milchkuhherden zu sammeln. Zudem sollte auf das Vorkommen von MRSA und ESBL-produzierenden…
(more)
▼ Das Ziel der Studie war, Informationen über den Einsatz von Antibiotika in
deutschen Milchkuhherden zu sammeln. Zudem sollte auf das Vorkommen von MRSA
und ESBL-produzierenden E. coli in Tankmilchproben untersucht werden.
Fragebögen wurden unter den Herdenmanagern von 60 norddeutschen Betrieben
(Herdengröße von 25 bis 3000 Tiere) verteilt, die auf freiwilliger Basis an
den Untersuchungen teilnahmen. Tankmilchproben wurden in den Betrieben
einmalig entnommen
und auf das Vorkommen von MRSA
und ESBL-produzierenden E.
coli untersucht. Zusätzlich wurden MRSA-Isolate aus Milch aus der
Stammsammlung des Nationalen Referenzlabors für koagulase-positive
Staphylokokken (inklusive S. aureus) (NRL Staph) mittels Multiplex PCR,
Sccmec-Typisierung, spa-Typisierung
und einem DNA-Microarray analysiert. Die
Herdenmanager benannten Lahmheiten, Metritiden
und Mastitiden als häufigste
Krankheitsprobleme der Kühe ihrer Betriebe. Neonataler Kälberdurchfall
und der
Kälbergrippekomplex (BRD) wurden als Hauptprobleme bei Kälbern angegeben.
Beta-Lactame, Tetrazykline, Makrolide, Sulfonamide, Fluoroquinolone,
Aminoglykoside, Phenikole
und Polypeptide waren die für erkrankte Tiere
eingesetzten Antibiotikaklassen auf den Betrieben. Ein Cephalosporin der
dritten Generation – Ceftiofur –, das zur Behandlung der Unterfußphlegmone
(Panaritium) zugelassen ist, war das zur Behandlung von Lahmheiten der Kühe
meist genutzte Antibiotikum. Amoxicillin, Tetrazykline
und Ceftiofur wurden
bevorzugt zur Behandlung von Metritiden eingesetzt. BRD bei Kälbern wurde
zumeist mit Florfenicol or Makroliden behandelt, während Fluoroquinolone die
Mittel der Wahl bei Durchfallkälbern waren. Nach Angaben der Herdenmanager
wurden monatlich im Durchschnitt 2.5% der Kühe aufgrund einer klinischen
Mastitis behandelt. In solchen Fällen wurden routinemässig Milchproben zur
bakteriologischen Untersuchung eingeschickt, seltener Proben von Kühen mit
erhöhten somatischen Zellzahlen. Für die Behandlung von Mastitiden wurden
Cefquinom, Penizillin
und die Kombinationen Cefalexin+Kanamycin
und
Ampicillin+Cloxacillin als häufigste genutzte Antibiotika angegeben. Die
meisten der untersuchten Betriebe (85% der Betriebe) wenden Routineverfahren
zum Trockenstellen an. Dies beeinhaltet eine intramammäre Applikation von
Antibiotika. Cloxacillin
und Cefquinom
und die Kombination von
Penethamathydrojodid + Benethamin-Penizillin + Framycetinsulfat wurden am
häufigsten zum Trockenstellen eingesetzt. Insgesamt wurden 36 MRSA-Isolate aus
Kuhmilch charakterisiert. Fünf Isolate wurden dabei aus Tankmilchproben, die
während der Betriebsbesichtigungen genommen wurden, gewonnen. 31 Isolate
stammten aus der Stammsammlung des NRL Staph. Die Zuordnung der Isolate zu
MRSA wurde Mithilfe einer Multiplex PCR
und DNAMicroarrayanalysen verifiziert.
Zwei verschiedene spa-Typen konnten ermittelt werden: t011 (22 Isolate)
und
t034 (14 Isolate). Dabei konnten 33 Stämme dem SCCmec Typ V, 2 Stämme dem
SCCmec Typ III
und nur ein Stamm dem SCCmec Typ IVa zugeordnet werden. Alle
MRSA-Stämme zeigten im Phänotyp…
Advisors/Committee Members: m (gender), Univ.-Prof. Dr. Kerstin E. Müller (firstReferee), PD Dr. Bernd-Alois Tenhagen (furtherReferee), Univ.-Prof. Dr. Karl-Hans Zessin (furtherReferee).
Subjects/Keywords: Germany; dairy cattle; drug therapy; drug resistance; Escherichia coli; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kreausukon, K. (2011). Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und
Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und
Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL
produzierende E. coli). (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11495
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kreausukon, Khwanchai. “Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und
Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und
Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL
produzierende E. coli).” 2011. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-11495.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kreausukon, Khwanchai. “Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und
Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und
Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL
produzierende E. coli).” 2011. Web. 22 Apr 2021.
Vancouver:
Kreausukon K. Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und
Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und
Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL
produzierende E. coli). [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-11495.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kreausukon K. Einsatz von Antibiotika in 60 Milchrinderbetrieben in Norddeutschland und
Charakterisierung von Methicillin-resistenten Staphylococcus aureus (MRSA) und
Extended-Spectrum Beta-Lactamase produzierenden Escherichia coli (ESBL
produzierende E. coli). [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-11495
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
17.
Tastutar, Timurhan.
an educational medium.
Degree: 2015, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-5575
► This Dissertation contains an educational medium which was created for veterinary students and veterinarians alike. It deals with cardiologic content for a more precise observation…
(more)
▼ This Dissertation contains an educational medium which was created for
veterinary students and veterinarians alike. It deals with cardiologic content
for a more precise observation of the heart valve insufficiencies of the
Horse. Cardiology is an essential part of the veterinary profession and a
crucial part of the overall check-up. The traditional educational methods are
in need of improvement. This also applies to sonographic cardiology. The
support of multimedia content is still missing while obtaining field
competence. Visual educational media is necessary to learn and understand the
fundamentals of cardiological examination and heart diseases. The three-
dimensional observation allow a better observation and evaluation of the
functions and disorders of the heart valves. This ensues through an innovative
3D-visualisation implemented in an E-Learning environment. The goal of this
dissertation is to fill the gap between the veterinary education and the
professional experience. To reach this goal, a virtual heart model was
designed. The heart valves and blood flow animation was added, to allow
different observation perspectives of the equine heart. A particle animation
method was used to demonstrate blood flow and simulate heart valve
insufficiencies. The heart valves where modelled with high detail for precise
observation. The combination of the heart valve models and the particle
animation are accurate simulations of the heart valve disorders. A
physiological 3D-model was also added to allow comparison between the
pathological and physiological valve movements. Echocardiography is an
undeniable, reliable and well established technology and is a standard
instrument in today’s veterinary cardiology. To use Echocardiography as a
trustworthy instrument. It is necessary to understand the cardiac structures,
functions and physiology. In this system, ultrasound sequences are displayed
parallel to 3D animation and pictures. The 3D animations show alternative
perspectives and are synchronizid to the ultrasound sequences. The third
dimension helps to understand the two-dimensional ultrasound view. The user
interface allows changes in video speed. On the lower left corner is a
scalable picture of the probe's position. The user interface contains a text
box. This allows the viewer to read necessary literature without leaving the
video page. The sources are added to promote further reading. The most common
heart valve insufficiencies and their blood flow disorders where animated to
offer the necessary fundamental knowledge.
Advisors/Committee Members: m (gender), Prof. Dr. Arthur Grabner i. R. (firstReferee), Univ.-Prof. Dr. Cordula Poulsen Nautrup (furtherReferee), Univ.-Prof. Dr. Johannes Handler (furtherReferee).
Subjects/Keywords: Equidae; cardiovascular disorders; E-learning; heart valves Ultrasonography; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tastutar, T. (2015). an educational medium. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5575
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tastutar, Timurhan. “an educational medium.” 2015. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-5575.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tastutar, Timurhan. “an educational medium.” 2015. Web. 22 Apr 2021.
Vancouver:
Tastutar T. an educational medium. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-5575.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tastutar T. an educational medium. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-5575
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
18.
Schlieben, Patricia.
Impact of Histological Grade and c-kit-Mutations on the Protein Expression
Profile of Canine Cutaneous Mast Cell Tumors.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-4609
► Cutaneous mast cell tumors (MCT) are one of the most common skin tumors in dogs. According to their histological appearance and the applied grading- system…
(more)
▼ Cutaneous mast cell tumors (MCT) are one of the most common skin tumors in
dogs. According to their histological appearance and the applied grading-
system two or three different histological grades have to be distinguished.
Grade 1 or low-grade MCT are characterized by well differentiated monomorphic
tumor cells which neither tend to metastasize nor recur. Grade 3 or high-grade
MCT are composed of dedifferentiated pleomorphic mast cells which often recur
or even metastasize to distant organs. Although mast cell tumors are in the
focus of research worldwide molecular details which provide the basis for this
different clinical behavior are in most aspects unknown. Studies about KIT,
the receptor for stem cell factor, and its proto-oncogene c-kit revealed
promising results, as the identification of an activating internal tandem
duplication in exon 11 lead to the assumption that KIT activity is of major
relevance to MCT proliferation and progression. Impact of c-kit-mutations on
the protein expression profile of mutated MCT cells is however unknown. Since
recent studies identified c-kit-mutations in only 12 % of all MCT and 40 % of
grade 3 MCT, other molecular alterations have to be responsible for the
aggressive clinical behavior of grade 3 MCT. Therefore, the present study
compared the protein expression patterns of grade 1 and grade 3 MCT (each n=5)
and of MCT with or without c-kit-mutation (each n=3) by two-dimensional
difference gel electrophoresis. Differentially expressed proteins were
identified by mass spectrometry subsequently. Tumors of distinct histological
grade differed in the expression of 13 proteins. Most of them are associated
with stress resistance, cell motility and mast cell differentiation. Further
studies are needed now to evaluate if these modified expressions patterns are
responsible for the aggressive clinical behavior of grade 3 MCT. The
comparison of c-kit-mutated and non-mutated MCT revealed 15 significantly
differentially expressed proteins. Contrary to the second hypothesis no
proteins with an association to increased proliferation activity were
detectable. These results substantiate the assumption that activating
mutations in the proto-oncogene c-kit are of less relevance for clinical
behavior than the histological grade.
Advisors/Committee Members: w (gender), Prof. Dr. Robert Klopfleisch (firstReferee), PD Dr. Michael Veit (furtherReferee), Univ.-Prof. Dr. Johanna Plendl (furtherReferee).
Subjects/Keywords: Cancer; Canis; mass spectrometry; mast cells; proteomics; tumours; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Schlieben, P. (2013). Impact of Histological Grade and c-kit-Mutations on the Protein Expression
Profile of Canine Cutaneous Mast Cell Tumors. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4609
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Schlieben, Patricia. “Impact of Histological Grade and c-kit-Mutations on the Protein Expression
Profile of Canine Cutaneous Mast Cell Tumors.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-4609.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Schlieben, Patricia. “Impact of Histological Grade and c-kit-Mutations on the Protein Expression
Profile of Canine Cutaneous Mast Cell Tumors.” 2013. Web. 22 Apr 2021.
Vancouver:
Schlieben P. Impact of Histological Grade and c-kit-Mutations on the Protein Expression
Profile of Canine Cutaneous Mast Cell Tumors. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-4609.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Schlieben P. Impact of Histological Grade and c-kit-Mutations on the Protein Expression
Profile of Canine Cutaneous Mast Cell Tumors. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-4609
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
19.
Reckzeh, Claudia.
Immunohistochemical analysis for deposits of scrapie prionprotein in ovine
tissues.
Degree: 2011, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-9343
► Six goats and 169 sheep carrying the genotype susceptible for PrPSc from a flock naturally infected with classical scrapie were culled and investigated for scrapie…
(more)
▼ Six goats and 169 sheep carrying the genotype susceptible for PrPSc from a
flock naturally infected with classical scrapie were culled and investigated
for scrapie using a rapid test on brainstem material (obex). Forty sheep
turned out to be TSE-positive. The remaining 135 animals (with a negative test
result in the obex region) were further investigated for the accumulation of
PrPSc in selected lymphatic and neuronal tissue samples in order to reveal the
actual prevalence in this affected flock and to assess the validity of the
brain stem based rapid test result. Furthermore potential ports of entry of
the agent and its spread throughout the body as well as the usefulness of
certain tissues for an antemortem diagnosis were investigated. The following
tissues were investigated immunohistochemically from all 135 animals: ileum,
ileocolic lymph node, retropharyngeal lymph node, tonsils and third eyelid. If
PrPSc in one of the above mentioned tissues was detected, other tissues were
checked for the presence of PrPSc (superficial cervical lymph node, spleen,
rectum, solar plexus, ganglion cervicale craniale, ganglion stellatum, vagus
nerve and tongue). In another 13 (10 %) out of 129 investigated sheep PrPSc
was detected in peripheral tissues. In total, 53 sheep tested positive for
PrPSc. That means that 24,5 % (13 sheep) had not been detected using rapid
test in the brain stem. Referring to the number of investigated sheep 7,7 % of
them were positive. The tissues producing positive results most frequently in
this study were the tonsil and the retropharyngeal lymph node each with nine
positive results, while ileum, superficial cervical lymph node and spleen were
positive in eight sheep respectively. In the solar plexus PrPSc was detected
in six sheep which also showed PrPSc in the enteric nervous system of the
ileum and three of them also of the rectum. Only two sheep were positive in
the third eyelid. All investigated tissues from the six goats tested negative.
In conclusion, this study shows that a negative result of the rapid test for
brain stem samples does not exclude the presence of PrPSc in peripheral
tissues. In consequence, the actual prevalence of scrapie is significantly
underestimated when it is only based on brainstem samples. Moreover this study
shows that lymphatic tissues such as the retropharyngeal lymph node and the
tonsil are meaningful tissues for a closer investigation, if more information
about the TSE-state of an animal is of any interest. In all, this study
supports possible ports of entry as well as the postulates of a progress of
PrPSc from the periphery to the CNS. The results from third eyelid and rectum
samples do not support the usefulness of antemortem tests using these tissues.
But an investigation of the tonsils provides an opportunity for early
diagnosis.
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Reinhard Fries (firstReferee), Prof. Dr. Martin Groschup (furtherReferee), Univ.-Prof. Dr. Michael Schmidt (furtherReferee).
Subjects/Keywords: scrapie; immunohistochemistry; nervous system; lymphatic system; sheep; goats; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Reckzeh, C. (2011). Immunohistochemical analysis for deposits of scrapie prionprotein in ovine
tissues. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9343
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Reckzeh, Claudia. “Immunohistochemical analysis for deposits of scrapie prionprotein in ovine
tissues.” 2011. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-9343.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Reckzeh, Claudia. “Immunohistochemical analysis for deposits of scrapie prionprotein in ovine
tissues.” 2011. Web. 22 Apr 2021.
Vancouver:
Reckzeh C. Immunohistochemical analysis for deposits of scrapie prionprotein in ovine
tissues. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-9343.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Reckzeh C. Immunohistochemical analysis for deposits of scrapie prionprotein in ovine
tissues. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-9343
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
20.
Irrgang, Alexandra.
Biochemical characterization of antigenic proteins from pathogenic Prototheca
species.
Degree: 2016, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-8731
► Prototheca spp. are unicellular, saprophytically living algae. Although these microorganisms belong to the phylogenetic group of the green algae, they are colorless due to the…
(more)
▼ Prototheca spp. are unicellular, saprophytically living algae. Although these
microorganisms belong to the phylogenetic group of the green algae, they are
colorless due to the absence of chlorophyll. Therefore their metabolism is
characterized as obligate heterotrophic. Macroscopically they bear a likeness
to yeasts of the genus Candida but the algae can be differentiated from them
easily under the microscope because they show no budding. Prototheca reproduce
asexually by the formation of endogenous daughter cells. They are of medical
and veterinary interest as some of the Prototheca species are associated with
infections in humans and animals, known as protothecosis. They fulfill all
qualifications to be highly pathogenic: a strong and resilient cell wall,
resistance against physical, chemical and mechanical stress, formation of a
resting cell stage and limited treatment options. However, protothecosis is a
relatively rare disease. The pathogenic agent, the pathogenicity as well as
the localization of the infection vary between the different host species.
Protothecosis may occur as local infection for example as cutaneous
manifestation but can run a disseminated course. There is little known about
the underlying mechanisms of pathogenicity. To lay the basis of understanding
the course of infection, the aim of this thesis was to determine
immunoreactive proteins of Prototheca zopfii GT2 by western blot analysis and
identify those using MALDI TOF MS. In the first part of this work, western
blot analysis was used to identify immunodominant protein spots using sera of
experimentally infected rabbits. With these 24 immunoreactive proteins of P.
zopfii GT2 were detected, from which 15 proteins could be identified by MALDI
TOF MS. Most of these proteins were proteins of regulatory functions and
enzymes of the metabolism. Some of them - malate dehydrogenase (MDH), heat
shock proteins 70 (Hsp70), elongation factor 1-α, (EF-1α) and 14-3-3 protein –
are known as immunoreactive proteins from other eukaryotic pathogens. Further
crossreactivity of the sera with proteins from P. zopfii GT1 and P. blaschkeae
was tested with a high success rate. 48 of these crossreactive proteins could
be determined using MALDI TOF MS, too. ATPase, MDH, EF-1α and Hsp70 were
identified from western blot analysis of all tested strains. In the second
part of this PhD thesis, experiments with sera from naturally infected dogs
were performed as above. The canine sera display a marked crossreactivity
between different species and genotypes, too. Taken together 198 proteins
spots were analyzed by MALDI TOF MS from which 86 were identified. Comparable
with the leporine sera, the main part of the immunoreactive proteins obtained
with canine infection sera were proteins of regulation, replication, protein
expression and metabolic enzymes. It is noticeable that MDH, Hsp70, EF-1α and
14-3-3 protein were also found as immunoreactive proteins. These are involved
in pathogenicity of the eukaryotic pathogens Anisakis sp., Schistosoma sp. and
Cryptococcus sp.…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Uwe Rösler (firstReferee), Univ.-Prof. Dr. Thomas Alter (furtherReferee), PD Dr. Karsten Nöckler (furtherReferee).
Subjects/Keywords: Prototheca; protothecosis; MALDI-TOF; western blot; antigens; virulence factors; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Irrgang, A. (2016). Biochemical characterization of antigenic proteins from pathogenic Prototheca
species. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8731
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Irrgang, Alexandra. “Biochemical characterization of antigenic proteins from pathogenic Prototheca
species.” 2016. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-8731.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Irrgang, Alexandra. “Biochemical characterization of antigenic proteins from pathogenic Prototheca
species.” 2016. Web. 22 Apr 2021.
Vancouver:
Irrgang A. Biochemical characterization of antigenic proteins from pathogenic Prototheca
species. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-8731.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Irrgang A. Biochemical characterization of antigenic proteins from pathogenic Prototheca
species. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-8731
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
21.
Brünig, Paula.
In-vitro and in-vivo studies on the efficacy of various microbial phytases as
feed additives.
Degree: 2010, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-9622
► Two E.coli phytases (Optiphos and FB-Phytase) were examined regarding their biochemical abilities (pH behaviour, temperature behaviour and –stability as well as proteolytic stability) to validate…
(more)
▼ Two E.coli phytases (Optiphos and FB-Phytase) were examined regarding their
biochemical abilities (pH behaviour, temperature behaviour and –stability as
well as proteolytic stability) to validate their suitability as feed
additives. The commercially available Aspergillus phytase Natuphos® has been
consulted as the comparing enzyme. The results of the pH behaviour show that
the pH optimum of the examined enzymes is located in the acidic range. The
optimal pH values of the E.coli phytases are 4.5 and 5.0, whereas Natuphos®
shows the best effect at pH 5.5. In the neutral pH range all enzymes are
inactive. The temperature optimum for the phytases was determined by
incubating the enzymes in a sodium acetate buffer with the optimal pH value
for each of the enzymes at eight different temperatures in the range of 30°C
to 80°C for 60 minutes. The subsequent determination of the phytase activity
showed a temperature optimum at 55°C for both E.coli phytases and an optimal
temperature of 50°C for the Aspergillus enzyme. The temperature stability of
the phytases was determined for three different temperatures and with a total
period of 120 minutes. The enzymes were incubated in sodium acetate buffer
with the optimal pH value for each of the enzymes. Afterwards the phytase
activity was determined. The measurements of temperature stability in aqueous
solution show that Natuphos® ist the most stable of the three examined
enzymes, whereas Optiphos is the least stable one. After 20 minutes of
incubation at 50°C Optiphos already has a residual phytase activity of less
than 10%, however FB-Phytase and Natuphos® exhibit residual activities of 60%
and 80% respectively. The phytases were also examined regarding their heat
stability during the pelleting process. In this case the Peniophora phytase
ZY-Phytase was consulted as the comparing enzyme. The phyases were added to a
mixed ration for pigs which was exposed to four different temperatures between
55°C and 85°C while pelletizing. The E.coli enzyme Optiphos (in the granulated
form) was the more stable E.coli phytase. At 85°C this enzyme had a residual
activity of 77%. The comparing enzyme Peniophora was also stable under these
conditions (96% residual activity at 85°C). The FB-Phytase was inactivated at
85°C both in the granulated form and as powder. The powder form of the
Optiphos enzyme was also not stable at 85°C. To assay the resistance of the
phytases against proteases the enzyme preparations were incubated in an
aqueous pepsin- or pancreatin solutionat 40°C. The results show that the
comparing enzyme Natuphos® is sensitive to pepsin but even more sensitive to
pancreatin. Optiphos lost about 45% of its activity in both media and is
therefore only moderately resistant to proteolytic inactivation. FB-Phytase is
relatively insensitive towards the pepsin inactivation (about 74% residual
activity). The influence of digesta supernatant on the enzymes has been tested
as well. The incubations were carried out at 40°C for 60 minutes in a digesta
solution from the stomach and proximal jejunum…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Ortwin Simon (firstReferee), Prof. Dr. Rainer Borriss (furtherReferee), Prof. Dr. Karl Heinz Lahrmann (furtherReferee).
Subjects/Keywords: feed additives; enzymes; phytase; in vitro; properties; piglets; efficacy; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Brünig, P. (2010). In-vitro and in-vivo studies on the efficacy of various microbial phytases as
feed additives. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9622
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Brünig, Paula. “In-vitro and in-vivo studies on the efficacy of various microbial phytases as
feed additives.” 2010. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-9622.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Brünig, Paula. “In-vitro and in-vivo studies on the efficacy of various microbial phytases as
feed additives.” 2010. Web. 22 Apr 2021.
Vancouver:
Brünig P. In-vitro and in-vivo studies on the efficacy of various microbial phytases as
feed additives. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-9622.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Brünig P. In-vitro and in-vivo studies on the efficacy of various microbial phytases as
feed additives. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-9622
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
22.
Kujawa, Anne.
Investigations on the specificity and sensitivity of the Thyroid Transcription
Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for
feline primary lung tumors.
Degree: 2016, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-13602
► The incidence of feline primary lung tumors has increased over the last decades. Yet, by comparison, feline lung tumors are poorly examined. Little is known…
(more)
▼ The incidence of feline primary lung tumors has increased over the last
decades. Yet, by comparison, feline lung tumors are poorly examined. Little is
known about correlations between tumor subtypes, tumor cell origin, prognosis
and clinical outcome. Currently, feline lung tumors are usually diagnosed
based on the classification of the World Health Organization (WHO), which is
based solely on histological features. This classification is not only
interpreted differently, but also criticized by various authors. A simple and
reliable diagnosis is essential for determining the tumor dignity and origin,
because feline primary lung tumors are frequently malignant and metastasize in
over 75 % of cases. Apart from that, the lung is one of the major centers for
metastases, making it difficult to differentiate primary lung tumors only on
the basis of histologic criteria. The aim of this study was to investigate the
sensitivity and specificity of Thyroid Transcription Factor-1 (TTF-1) and the
function of Ki67 as malignancy markers for feline primary lung tumors and to
examine, whether they support or facilitate the application of the current WHO
classification. For this purpose, 1) the actual applicability of the existing
WHO classification was determined, 2) relevant tumor characteristics were
acquired, 3) the specificity of TTF-1 for feline lung tumors was examined, 4)
correlations between TTF-1 expression levels, the tumor characteristics and
tumor dignity were discussed, 5) the expression of the proliferation marker
Ki67 was surveyed in the tumors, 6) the diagnostic potential of a combination
of TTF-1 and Ki67 was analyzed and 7) the benefit of both markers and their
combination for the classification of feline primary lung tumors was tested.
According to the histological criteria of the WHO guidelines, 61 feline lung
tumors were initially classified. In the process, various features, specific
for different tumor subtypes, occurred frequently in the same tumor.
Furthermore, the described cell characteristics associated with certain growth
patterns (papillary, bronchioloalveolar) differed from the actually occurring
tumor cells. The applicability of the tumor classification remained generally
very limited, since the feature descriptions were unclear and partly
contradictory. In the second part of this thesis, the lung tumor marker TTF-1,
already established in human medicine, was examined for its specificity for
feline lung tumors. Immunohistochemical stainings confirmed its specificity
for feline lung tumors and a relation between its expression and the tumor
dignity. The results revealed a positive correlation between the TTF-1
expression and tumor differentiation grade. Since TTF-1 is only expressed in
benign but not all malignant lung tumors, its potential as a tumor marker is
limited in diagnostic practice. Furthermore, the expression of the
proliferation marker Ki67 was also explored in the tumors. As expected, its
expression negatively correlated with the degree of differentiation. Thus, the
Ki67 expression was…
Advisors/Committee Members: [email protected] (contact), w (gender), Univ.-Prof. Dr. Robert Klopfleisch (firstReferee), PD Dr. Sebastian Arlt (furtherReferee), PD Dr. Kerstin Müller (furtherReferee).
Subjects/Keywords: cats; lung cancer; transcription factors; immunohistochemistry; markers; WHO, classification; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kujawa, A. (2016). Investigations on the specificity and sensitivity of the Thyroid Transcription
Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for
feline primary lung tumors. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13602
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kujawa, Anne. “Investigations on the specificity and sensitivity of the Thyroid Transcription
Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for
feline primary lung tumors.” 2016. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-13602.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kujawa, Anne. “Investigations on the specificity and sensitivity of the Thyroid Transcription
Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for
feline primary lung tumors.” 2016. Web. 22 Apr 2021.
Vancouver:
Kujawa A. Investigations on the specificity and sensitivity of the Thyroid Transcription
Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for
feline primary lung tumors. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-13602.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kujawa A. Investigations on the specificity and sensitivity of the Thyroid Transcription
Factor-1 (TTF-1) and the proliferation marker Ki67 as malignancy markers for
feline primary lung tumors. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-13602
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
23.
Bruhnke, Alexandra.
Effect of horse shoeing on the perfusion of the corium in the solear margin.
Degree: 2015, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-6495
► From the following two phenomena the question arises whether shoeing horses regularly with iron horse shoes and nails may determine a compression of the circumflex…
(more)
▼ From the following two phenomena the question arises whether shoeing horses
regularly with iron horse shoes and nails may determine a compression of the
circumflex artery of the sole and the area it supplies initiated by the direct
pressure of the shoeing and thus be the cause for various acute and chronic
dysfunctions occurring in hoof shoeing. The first phenomena is the often
observed clammy movement of newly shod horses and the second is the detectable
extinction of blood vessel patterns in the corium of the hoof when compressed
by a hoof examination forceps. From 31 horses with healthy hooves that died or
were euthanized at the Equine hospital of the Free University of Berlin, 71
specimens of hooves were obtained. The specimens were divided in three Groups:
28 of the formerly unshod specimens were shod by different techniques (tightly
studded, loosely studded, and normally studded but weakened hoof sole), 18 of
the specimens were already shod when obtained and left that way and 25 of the
formerly unshod stayed unshod as reference group. The circumflex artery of the
sole has been displayed by a radiographic contrast agent study of the coffin
bone. Subsequently, the angiograms were examined for disruptions of the
contrast filling in the circumflex artery of the sole. The results of this
study did not reveal a correlation between filling defects at the circumflex
artery of the sole and shoeing. Twelve percent (3/25) of the unshod reference
group, 5,6% (1/18) of the previously shod and 7,1% (2/28) of the
experimentally shod specimen showed at least one disruption of the circumflex
artery of the sole. Shoeing horses with iron horse shoes and nails using
correct shoeing technique could not produce a compression of the circumflex
artery of the sole - even in specimens with thin soles. The experimental
assembly did not allow any conclusion as to whether a compression of the
circumflex artery of the sole relevant to blood flow could be induced when
body weight of the horse and strain of movement are taken into consideration.
Furthermore, pathophysiologic mechanism of tissue due to shoeing such as local
inflammation triggering contraction of blood vessels and reduction of blood
flow could not be observed with this study design. In vivo angiographic
studies would be necessary to further evaluate these important questions.
Advisors/Committee Members: w (gender), Univ.- Prof. Dr. Christoph Lischer (firstReferee), Univ.-Prof. Dr. Johanna Plendl (furtherReferee), Prof. Dr. a. D. Klaus- Dieter Budras (furtherReferee).
Subjects/Keywords: horses; lameness; hooves; blood vessels; schoeing; orthopaedics; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bruhnke, A. (2015). Effect of horse shoeing on the perfusion of the corium in the solear margin. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6495
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bruhnke, Alexandra. “Effect of horse shoeing on the perfusion of the corium in the solear margin.” 2015. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-6495.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bruhnke, Alexandra. “Effect of horse shoeing on the perfusion of the corium in the solear margin.” 2015. Web. 22 Apr 2021.
Vancouver:
Bruhnke A. Effect of horse shoeing on the perfusion of the corium in the solear margin. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-6495.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bruhnke A. Effect of horse shoeing on the perfusion of the corium in the solear margin. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-6495
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
24.
Zauscher, Johanna Maria Martina.
Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim
Pferd.
Degree: 2013, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-8512
► Größenveränderungen des Fesseltrageapparats des Pferdes werden besonders im Bereich des Ursprungs bevorzugt zur Diagnose von Erkrankungen und zur Beurteilung des Heilungsverlaufes durchgeführt, da pathologische Form-…
(more)
▼ Größenveränderungen des Fesseltrageapparats des Pferdes werden besonders im
Bereich des Ursprungs bevorzugt zur Diagnose von Erkrankungen
und zur
Beurteilung des Heilungsverlaufes durchgeführt, da pathologische Form-
und
Strukturveränderungen gerade dort nicht immer sicher von normalen Befunden zu
unterscheiden sind. Der individuell sehr unterschiedliche Gehalt an
Muskelfasern führt im Bereich des Fesselträgerursprungs
und des
Fesselträgerkörpers zu einem Ultraschallbild mit variabler Echogenität. Auch
verursachen Gefäßanastomosen
und überlagernde Sehnen
und Bänder Artefakte im
Verlauf des gesamten Fesseltrageapparats mit Ausnahme der
Fesselträgerschenkel. Ziel der Studie war es, die Präzision von Messungen im
Bereich des Ursprungs, des Körpers
und der Schenkel des Fesselträgers sowie
des geraden
und der schrägen Gleichbeinbänder an Vorder-
und Hinterbeinen des
Pferdes zu untersuchen. Zusätzlich wurden im Bereich des Fesselträgerursprungs
verschiedene sonographische Untersuchungstechniken zur Größenmessung
evaluiert. 14 gesunde Pferde (sechs Traber, sechs Araber-Mix, ein Warmblut,
ein Quarter Horse) im Alter von 5 - 28 Jahren wurden an allen vier Gliedmaßen
sonographisch untersucht. Anhand von longitudinalen
und transversalen
Ultraschallbildern, die mit einer Linearsonde (12 MHz) erstellt wurden, wurde
die Tiefe, die Breite, der Umfang
und die Fläche an, durch die Anatomie
definierten, Stellen gemessen. Im Bereich des Ursprungs wurde auch eine
Microconvexsonde (8 MHz) eingesetzt. Ebenfalls im Ursprungsbereich der
Vordergliedmaße wurde zusätzlich an der gebeugten Gliedmaße mit einer
Linearsonde
und einer Microconvexsonde ein Sonogramm erstellt. Zwei
Untersucher sonographierten die Tiere je zweimal im Abstand von mindestens
einem Tag. Die Scans wurden im Archiv des Ultraschallgerätes gespeichert
und
dort ausgemessen. Die inter-
und intraobserver Variabilität wurde mittels des
mean agreement index
und 95% limits of agreement (Bland
und Altmann 1986)
bestimmt. Zu den zuverlässigeren Messungen gehörten im longitudinalen
Sonogramm die Messung der Tiefe in den Bereichen des Fesselträgerursprungs
und
der Fesselträgerschenkel
und im transversalen Sonogramm die Messung des
Umfangs in den Bereichen der Fesselträgerschenkel
und des geraden
Gleichbeinbandes in der distalen Fesselbeuge. Alle Messungen im Bereich des
Fesselträgerkörpers
und der schrägen Gleichbeinbänder hatten eine geringe
Reliabilität. Die Zuverlässigkeit der Messungen der Größe im Bereich des
Fesseltrageapparats sollten berücksichtigt werden, wenn diese verwendet werden
um klinische Entscheidungen zu treffen.
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Christoph Lischer, Dipl. ECVS, Assoc. Dipl. ECVDI Large Animal (firstReferee), Univ.-Prof. Dr. Johannes Handler, Dipl. ECAR (furtherReferee), Prof. Dr. K. D. Budras (furtherReferee).
Subjects/Keywords: horses; ultrasonograpy; ultrasound; limbs; ligaments; repeatability; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zauscher, J. M. M. (2013). Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim
Pferd. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8512
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zauscher, Johanna Maria Martina. “Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim
Pferd.” 2013. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-8512.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zauscher, Johanna Maria Martina. “Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim
Pferd.” 2013. Web. 22 Apr 2021.
Vancouver:
Zauscher JMM. Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim
Pferd. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-8512.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zauscher JMM. Die Präzision von ultrasonographischen Messungen am Fesseltrageapparat beim
Pferd. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-8512
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
25.
Whelan, Rose.
Ein transgenes probiotisches Bakterium als ein Träger für ein
immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen
Entzündungen.
Degree: 2015, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-13115
► Chronisch-entzündliche Darmerkrankungen (CED) sind Autoimmunerkrankungen, die durch eine ungeregelte Darmentzündung gekennzeichnet werden. Heutige Therapien sind nicht bei allen betroffenen Patienten wirksam und oft mit unerwünschten…
(more)
▼ Chronisch-entzündliche Darmerkrankungen (CED) sind Autoimmunerkrankungen, die
durch eine ungeregelte Darmentzündung gekennzeichnet werden. Heutige Therapien
sind nicht bei allen betroffenen Patienten wirksam
und oft mit unerwünschten
Nebenwirkungen verbunden. Daher besteht ein dringender Bedarf für die
Entwicklung neuer Behandlungsmethoden. Parasitische Nematoden sekretieren
immunmodulatorische Moleküle, die es ihnen gestatten, längerfristig im Wirt zu
überleben
und sich dort fortzupflanzen. Studien mit an CED erkrankten Menschen
und experimentell herbeigeführten Darmentzündungen bei Mäusen zeigten, dass
die Immunmodulation der Nematoden die Symptome von CED sowohl bei Menschen als
auch bei Mäusen abmilderte. Cystatin, welches von der Filarie
Acanthocheilonema viteae sekretiert wird (AvCys), wirkt stark
entzündungshemmend bei Kontakt mit Immunzellen, vor allem bei Makrophagen.
Eine neuartige Behandlung von CED wurde unter Verwendung des probiotischen
Bakteriums Escherichia coli Nissle 1917 (EcN) entwickelt. Hierbei werden
transgene Bakterien, welche das AvCys Gen exprimieren, in den Wirtsdarm
eingebracht um eine anhaltende Applikation des entzündungshemmenden Cystatins
direkt vor Ort zu ermöglichen. Der Einsatz der transgenen EcN-AvCys Probiotika
bei Mäusen mit akuter Kolitis bewirkte eine deutliche Reduktion der Expression
von Chemoattraktanzien, der Einwanderung von Entzündungszellen
und der
T-Zellantwort im Darm. Dies führte zu einer insgesamt drastisch reduzierten
Entzündungsreaktion. Da der Magen-Darmtrakt von Schweinen sehr dem des
Menschen ähnelt, wurde die entzündungshemmende Aktivtät von EcN-AvCys
daraufhin an einer genetisch diversen Versuchstierpopulation von Hausschweinen
getestet. Dabei wurden Ferkeln, die nach der Entwöhnungsphase an einer
Darmfehlfunktionen litten, wiederholt hohe Dosen von EcN-AvCys verabreicht.
Die Behandlung reduzierte erheblich die Darmentzündungen
und stellte überdies
kein Risiko für die Körpergewichtsentwicklung
und Immunfunktion der Ferkel
dar. Um die mechanistische Grundlage für die antiinflammatorische Wirkung von
EcN-AvCys zu analysieren, wurde der Phänotyp der Monocyten der Schweine unter
verschiedenen Bedingungen untersucht: (1) nach Inkubation mit Überständen aus
Zellkulturen von EcN, (2) EcN-AvCys bzw. (3) rekombinantem AvCys. Während
rekombinates AvCys sehr wenig Einfluss auf die Expression von Monozyten-
Markergenen hatte, induzierten die Überstände von sowohl EcN als auch EcN-
AvCys Kulturen gleichsam eine frühe Expression von M1-assoziierten Markern
sowie regulatorischem IL-10. Anschließend wurde die Hypothese getestet, dass
AvCys die entzündungsfördernden Makrophagen-Funktionen stören könnte indem
durch Beeinträchtigung des Inflammasoms die Aktivierung des
entzündungsfördernden Zytokins IL-1ß gehemmt wird. Hierzu wurden Monozyten
und
Makrophagen mit Überständen der transgenen
und Kontrollkulturen der
probiotischen Bakterien inkubiert, wobei die Sekretion von IL-1ß überwacht
wurde. Anstatt die Sekretion von IL-1ß als Reaktion auf die Induktion des
Inflammasoms zu…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Susanne Hartmann (firstReferee), Univ.-Prof. Dr. Lothar Wieler (furtherReferee), Prof. Dr. Britta Siegmund (furtherReferee).
Subjects/Keywords: Inflammatory Bowel Disease; probiotics; nematoda; intestinal mucosa; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Whelan, R. (2015). Ein transgenes probiotisches Bakterium als ein Träger für ein
immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen
Entzündungen. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13115
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Whelan, Rose. “Ein transgenes probiotisches Bakterium als ein Träger für ein
immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen
Entzündungen.” 2015. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-13115.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Whelan, Rose. “Ein transgenes probiotisches Bakterium als ein Träger für ein
immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen
Entzündungen.” 2015. Web. 22 Apr 2021.
Vancouver:
Whelan R. Ein transgenes probiotisches Bakterium als ein Träger für ein
immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen
Entzündungen. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-13115.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Whelan R. Ein transgenes probiotisches Bakterium als ein Träger für ein
immunmodulatorisches Nematoden-Protein für die Behandlung von intestinalen
Entzündungen. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-13115
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
26.
Padberg, Wiebke.
Efficacy of biological drugs as prophylaxis of endometritis in dairy cows.
Degree: 2011, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-4919
► The objective in this study was to evaluate the efficacy of the homotoxicologic drugs Lachesis comp. ad us. vet.®, Carduus comp. ad us. vet.® and…
(more)
▼ The objective in this study was to evaluate the efficacy of the
homotoxicologic drugs Lachesis comp. ad us. vet.®, Carduus comp. ad us. vet.®
and Traumeel® for the prevention of endometritis in dairy cows. The study was
conducted as a randomised, controlled and blinded field- trial on a
conventional dairy farm in Brandenburg. Two protocols of therapy were compared
to a placebo group. A total of 593 animals (404 dairy cows, 189 heifers) were
included into this study. The drugs were injected subcutaneously four times at
weekly intervals. The first injection was given within 24 hours after calving.
The first examination of the study animals was carried out on the day of the
last injection (PK 1, 21.- 27. day pp). Uterine involution and ovarian
follicular development was monitored by visual inspection, rectal palpation
and by ultrasonography. At the same time, blood samples from the coccygeal
vein were taken from 291 animals. To determine the resumption of cyclic
activity, the concentration of serum progesterone was measured. Also, the
concentrations of betahydroxybutyrat (BHBA) and nonesterified fatty acids
(NEFA) in blood serum were examined to establish the metabolic status of the
animals. If endometritis or deficient ovarian activity was diagnosed, the
examination was repeated at PK 2 (28.- 34. day pp) and PK 3 (35.– 41 day pp),
respectively. Data from all animals were collected including history of
calving, retained placenta and twins. If study animals showed signs of
sickness like serious injuries because of calving, displaced abomasum,
hypocalcaemia or anomalies of the uterus they were excluded from the study.
Animals, which were treated systemically or intrauterine with antibiotics or
hormones within 72 days after calving were excluded equally. All results of
examination were documented and classified. The interpretation of the results
from examinations were made for all animals as well as for cows and heifers.
Regarding frequency or severity of endometritis, a positive influence of the
homotoxicologic drugs could not be found for any date of examination.
Resumption of ovarian activity did not differ significantly between the three
study groups as well as the distribution of BHBA- and NEFA- concentration in
blood serum. Days to first service, days open, first- service conception rate
and conception rate were determinated. The differences between the groups were
not significant. The reason for leaving was documented and analyzed for all
animals, left the dairy farm within 200 days pp. There were no significant
differences between the groups, also. Our data show that the homotoxicologic
drugs and protocols of therapy evaluated in this study was not efficacious.
Further research is required to investigate the possibilities of a different
combination of homotoxicologic drugs or different times of treatment.
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. W. Heuwieser (firstReferee), Prof. Dr. Robby Andersson (furtherReferee), PD Dr. Bernd- Alois Tenhagen (furtherReferee).
Subjects/Keywords: Dairy cows; chronic endometritis; Lachesis compositum; Carduus compositum; Traumeel; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Padberg, W. (2011). Efficacy of biological drugs as prophylaxis of endometritis in dairy cows. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4919
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Padberg, Wiebke. “Efficacy of biological drugs as prophylaxis of endometritis in dairy cows.” 2011. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-4919.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Padberg, Wiebke. “Efficacy of biological drugs as prophylaxis of endometritis in dairy cows.” 2011. Web. 22 Apr 2021.
Vancouver:
Padberg W. Efficacy of biological drugs as prophylaxis of endometritis in dairy cows. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-4919.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Padberg W. Efficacy of biological drugs as prophylaxis of endometritis in dairy cows. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-4919
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
27.
Rabbani, Imtiaz.
Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im
Pansenepithel des Schafes.
Degree: 2010, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-13532
► Zahlreiche Studien belegen, dass das Pansenepithel sich sowohl in funktioneller, als auch in morphologischer Hinsicht an Veränderungen in der Fütterung anpassen kann. Dieser Prozess kann…
(more)
▼ Zahlreiche Studien belegen, dass das Pansenepithel sich sowohl in
funktioneller, als auch in morphologischer Hinsicht an Veränderungen in der
Fütterung anpassen kann. Dieser Prozess kann Tage oder Wochen dauern; jedoch
werden auch kurzfristige tägliche Schwankungen im pH des Pansens beobachtet,
welcher insbesondere nach den Mahlzeiten
und im Falle von SARA für 3-4 Stunden
auf sehr niedrige Werte (<5.5) absinken kann. Diese tägliche Variation im pH
Wert
und in der Fettsäurekonzentration im Pansen stellt eine starke Belastung
für das Pansenepithel dar
und protektive Mechanismen sind erforderlich, um
diesen akuten Belastungsschüben zu begegnen. Es war daher die Absicht dieser
Studie, die Schutzfunktion eines Heat Shock Proteins (Hsp70)
und des NHEs an
Epithelien des Pansens zu untersuchen, welche auf der mukosalen Seite
Veränderungen im pH, in der Konzentration kurzkettiger Fettsäuren, in der
Temperatur oder dem osmotischen Druck ausgesetzt worden waren. Um die
protektive Funktion dieser Proteine zu untersuchen, wurde der Transport von Na
und Azetat über das Pansenepithel in konventionellen Untersuchungen in der
Ussingkammer in vitro gemessen. Begleitend wurde an Tieren, bei welchen durch
Konzentratfütterung im Pansen SARA-ähnliche Fermentationsbedingungen induziert
worden waren, die in vivo Expression von Hsp70 untersucht. Die folgenden
Ergebnisse wurden erhalten: 1\. Die Charakterisierung des elektroneutralen
Natriumtransportes durch NHE zeigte klar, dass die Isoform NHE3 den
elektroneutralen Natriumtransport vermittelt. Applikation des spezifischen
NHE3 Blockers S3226 reduzierte Jms Na
und Jnet, welche sich danach nicht
signifikant vom gleichbleibenden Isc unterschieden. Dieses weist darauf hin,
dass S3226 den elektroneutralen Natriumtransport hemmt. 2\. Die Inkubation von
isoliertem Pansenepithel in der Ussingkammer unter SARA ähnlichen Bedingungen
mit niedrigem pH (6.4-6.0)
und/oder hoher Konzentration kurzkettiger
Fettsäuren (70-80 mmol·l-1), ansteigender Temperatur oder Zunahme des
osmotischen Druckes induzierte eine Überexpression von Hsp70. Diese Expression
wurde reduziert wenn die Stressoren ein bestimmtes Maß überschritten. So kam
es z.B. bei einer Zunahme der Temperatur >44ºC, einer Konzentration von
kurzkettigen Fettsäuren >100 mM
und einem Abfall des pHs auf der mukosalen
Seite >5.5 zu einem Abfall der Hsp70 Expression. 3\. Die Expression von Hsp70
konnte durch einen nicht-spezifischen (Cycloheximid) oder spezifischen
(Triptolid) Inhibitor abgesenkt werden, wodurch weitere Untersuchungen in der
Anwesenheit
und Abwesenheit von Hsp70 ermöglicht wurden. Cycloheximid war am
effektivsten in einer Konzentration von 3.0 mmol·l-1, während Triptolid in
einer Konzentration von 100 nmol·l-1 eingesetzt wurde. Unter
Kontrollbedingungen hatte der Gebrauch dieser Inhibitoren weder auf den
Kurzschlussstrom (Isc) noch auf die Leitfähigkeit (Gt), die Na- oder die
Azetatfluxe einen Einfluss. 4\. Der elektroneutrale Transport von Na
und der
Transport von Azetat waren signifikant höher nach Überexpression von Hsp70.
Diese…
Advisors/Committee Members: m (gender), Univ.-Prof. Dr. H. Martens (firstReferee), Univ.-Prof. Dr. A. Richter (furtherReferee), Univ.-Prof. Dr. K. E. Müller (furtherReferee).
Subjects/Keywords: rumen; epithelium; ion transport; sodium; heat shock proteins; sheep; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rabbani, I. (2010). Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im
Pansenepithel des Schafes. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13532
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rabbani, Imtiaz. “Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im
Pansenepithel des Schafes.” 2010. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-13532.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rabbani, Imtiaz. “Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im
Pansenepithel des Schafes.” 2010. Web. 22 Apr 2021.
Vancouver:
Rabbani I. Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im
Pansenepithel des Schafes. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-13532.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rabbani I. Modulation des Na- und Acetat-Transports durch Heat Shock Proteine im
Pansenepithel des Schafes. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-13532
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
28.
Hanebeck, Christine.
a contribution to the cultural history of pig especially considering the ergot
intoxikation.
Degree: 2011, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-12619
► As the result of the investigation of the connection between St. Antony “the Great” and the pig is confirmed, that this is not based on…
(more)
▼ As the result of the investigation of the connection between St. Antony “the
Great” and the pig is confirmed, that this is not based on the historical
original person from the 4th century, but rather exclusively it is based on
the work of the biggest hospice-order of the Middle Ages, the Antoniter-order.
The biography of the historical original person Antony has been come down with
the "Vita Antonii" of Athanasius of Alexandria in detail. Important points of
the church-political and theological discussions of it`s writing time have
slipped in onto this biography of the old- egypt hermit Antony. In this
context a traditional teaching speech of St. Antony has to be integrated in
which is citing the biblical story about the “Healing of the demented man”, in
which is pointed to understanding the pig as an impure animal. Domestic
animals, in particular the pig, are picked out as a central theme at no place
of “Vita Antonii”. Therefore domestic animals, in particular the pig, can not
be associated with historical Antonius. However, the tip on the pig in
connection with demonic power refers in general to the jewish and early-
christian understanding of the pig as an impure animal. This understanding
existed in the old Orient and later in the whole mediterranean area, often
beside the traditionally existing esteeming understanding of this for a long
time domesticated animal by the hereditary population groups. Till the Middle
Ages the disparaging judgement of the pig as an impure animal could keep
itself partial, although it had become in many parts of Europe the most
important meat supplier for population`s feeding. The connection of St. Antony
“the Great” with the pig is to be settled chronologically only in the Middle
Ages. The Antoniter-order which originated in 1247 in France and which went
out from a charitable active lay brotherhood, developed to the biggest and
mightiest hospice-order of the Middle Ages. It refers to St. Antony as the
order-patron. The Antoniter-order devoted itself to the care and therapy of
people poisoned with ergot and to the care of the recovered people, who often
had to live on as a cripple. Within the scope of their activity the Antoniter
specialized in the diagnostics and therapy in particular of the gangrenous
form of this Intoxikation. They rendered outstanding services to the medieval
hospice system, to the development of special therapeutic attempts as well as
to the spreading of medical specialist knowledge of their time. To cover the
required material basis for it`s work the order set up a highly organized
collective system, the "Quest". It became usual that the population
-predominantly living in agrarian structures- donated either collectively
drawn up battle pigs or piglets to further fatten as natural contributions.
Pigs were suitable on account of their quickly growing up and of their
uncomplicated breeding (keeping in forest; feeding with food rubbish)
particularly for an effective food production. In this connection the
Antoniter developed…
Advisors/Committee Members: w (gender), Priv.-Doz. Dr. Eberhard Uecker (firstReferee), Univ.-Prof. Dr. Kerstin Müller (furtherReferee), Priv.-Doz. Dr. Rainer Struwe (furtherReferee).
Subjects/Keywords: veterinary history; Claviceps purpurea; ergotism; swine diseases; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hanebeck, C. (2011). a contribution to the cultural history of pig especially considering the ergot
intoxikation. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12619
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hanebeck, Christine. “a contribution to the cultural history of pig especially considering the ergot
intoxikation.” 2011. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-12619.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hanebeck, Christine. “a contribution to the cultural history of pig especially considering the ergot
intoxikation.” 2011. Web. 22 Apr 2021.
Vancouver:
Hanebeck C. a contribution to the cultural history of pig especially considering the ergot
intoxikation. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-12619.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hanebeck C. a contribution to the cultural history of pig especially considering the ergot
intoxikation. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-12619
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
29.
Balczulat, Stefanie.
Investigations on different genotypes and investigations on the carbohydrate
metabolism of Histomonas meleagridis.
Degree: 2014, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-9922
► Histomonosis, blackhead disease or infectious typhlohepatitis of the gallinaceous birds is caused by the protozoen parasite or Trichomonad Histomonas meleagridis. The disease is characterized by…
(more)
▼ Histomonosis, blackhead disease or infectious typhlohepatitis of the
gallinaceous birds is caused by the protozoen parasite or Trichomonad
Histomonas meleagridis. The disease is characterized by an inflammation of the
ceca and liver damages. The mortality in turkey flocks can reach 90 %. The
first part of this thesis included investigations and analysis of different
genotypes of H. meleagridis. The first studies were done on 568 samples, which
had been send to the Institute for Poultry Diseases and were tested for H.
meleagridis using a qPCR. The samples originated from 252 suspected cases of
histomonosis of the years 2004 till 2010. Of the 568 samples 209 samples were
positive, 357 samples negative and 2 samples questionable. Four hundred
seventy three samples were organs including 193 ceca, 190 livers and 42 pools
of ceca and liver. 48 samples were different organes like gizzard, rectum,
cloaca, spleen, kidney, oesophagus or pancreas. 252 of the organ samples were
from turkeys and 176 from chickens. Only 19 samples were from other
gallinaceous birds like peacocks, pheasants, snow cocks, guinea fowls and
quails and were tested with mostly negative result. The species of 29 samples
was unknown. Of 46 samples of invertebrates and 42 samples of the environment
only eight and four samples respectively were positive, while 38 each were
negative. For genotyping the method of the C-Profiling was modified by
designing primers specific for H. meleagridis. One hundred twenty five
samples, that were positiv for H. meleagridis, were genotyped. The ITS1-region
of this samples was C-profiled. Five different profiles were found (type A
through E). Type A was the most frequently detected type in over half the
samples. Types B and C were mostly found in turkey samples. Type D occured
only in chicken samples and in one peacock sample. Type E was found in only
one chicken sample. Furthermore 273 samples were tested for the presence of
Blastocystis spp. And Tetratrichomonas gallinarum. There was a significant
relationship between the occurrence of histomonosis and the concurrent absence
of T. gallinarum. In contrast the relationship between H. meleagridis and
Blastocystis ssp. was not significant. The second part of the thesis dealt
with investigations on the metabolism of H. meleagridis. Several experiments
on the cultivation were done. First the effect of the buffers MOPS and HEPES
were tested. With 5, 25 or 100 mmol/L HEPES and with 50 or 100 mmol/L MOPS
respectively histomonads grew well. In concentrations of 250 mmol/L MOPS or
HEPES no histomonal growth was observed. In the following experiments the
influence of different starch sources and carbohydrates instead of rice powder
were tested. Starch sources were potato starch, amylose, amylopectin and
glycogen. Only potato starch supported histomonal growth. The carbohydrates
glucose, pyruvate, glucose-1-phosphat, glucose-6-phosphat and maltose were
tested in different concentrations with or without the addition of rice.
Cultures without rice survived at best. Often they died. Growth…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Hafez Mohamed Hafez (firstReferee), Univ.-Prof. Dr. Georg von Samson-Himmelstjerna (furtherReferee), Prof. Dr. Peter-Henning Clausen (furtherReferee).
Subjects/Keywords: Histomonas meleagridis; genotypes; polymerase chain reaction; Galliformes; carbohydrate metabolism; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Balczulat, S. (2014). Investigations on different genotypes and investigations on the carbohydrate
metabolism of Histomonas meleagridis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9922
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Balczulat, Stefanie. “Investigations on different genotypes and investigations on the carbohydrate
metabolism of Histomonas meleagridis.” 2014. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-9922.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Balczulat, Stefanie. “Investigations on different genotypes and investigations on the carbohydrate
metabolism of Histomonas meleagridis.” 2014. Web. 22 Apr 2021.
Vancouver:
Balczulat S. Investigations on different genotypes and investigations on the carbohydrate
metabolism of Histomonas meleagridis. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-9922.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Balczulat S. Investigations on different genotypes and investigations on the carbohydrate
metabolism of Histomonas meleagridis. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-9922
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin
30.
Hellauer, Andrea Karin.
Effect of different head-neck-positions on endoscopic findings of the upper
airway tract and on stress associated parameters in the ridden horse.
Degree: 2014, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-8715
► In recent years one can observe more and more frequently the use of hyperflexion, the so-called "rollkur" at ridden horses in education, training, but also…
(more)
▼ In recent years one can observe more and more frequently the use of
hyperflexion, the so-called "rollkur" at ridden horses in education, training,
but also in competitions. The aim of this study was on the one hand, in a
preliminary study, to test the applicability of the overground endoscopy under
natural training conditions and on the other hand, in the main study, to
investigate the effects of different head-neck-positions on endoscopic
findings of the upper respiratory tract and stress parameters in the ridden
horse. In the preliminary study a total of 30 horses of different types of use
were examined. One-third were each gallop racing horses, trotters and riding
horses. The horses were investigated in their natural environment under real
training conditions with the overground endoscope. The behaviour during the
application of the equipment and during the investigation was documented and
the endoscopic images were recorded. Later, these were evaluated with regard
to their picture quality and ease of interpretation. Overall, the study was
very well practicable in most horses. Four horses showed strong defensive
movements during insertion of the endoscope and in three of these horses the
investigation had to be cancelled. The remaining horses were all trainable
with the inserted endoscope, only one horse has shown slight head shaking
during exercise. Two horses have developed slight nosebleeds during
investigation. The quality of images was high enough to evaluate findings of
the upper respiratory tract. The preliminary investigation has revealed that
the new technique of overground endoscopy is an available option to examine
horses under natural training conditions endoscopically. The application has
been practicable in the field and most of the horses have tolerated the
investigation. Furthermore goal of the present study was a comparison between
the impacts of different head-neck-positions on findings in the upper
respiratory tract of ridden horses. For this purpose video recordings of the
larynx of 14 horses were recorded using the above mentioned overground
endoscope. The videos were recorded at rest and during three different riding
phases: first at stretching posture, secondly at a working head-neck-position
and thirdly at hyperflexion. In comparison between the phases working head-
neck-position and hyperflexion the analysis revealed a significant reduction
of the laryngeal opening area (p = 0.001) with a value of 8.2 ± 5.0%. Beyond
that, other evaluated parameters of the larynx, except its height, showed a
significant diminishment as well. These changes did not correlate with the age
of the horses or their level of education and they were independent of the
individual anatomic conditions of the head-neck region. Capitulatory it can be
stated that hyperflexion has caused a considerable compression of the larynx.
In the present study the influence of different head-neck-positions on stress
parameters were investigated, too. In 18 horses heart rate, heart rate
variability (HRV) and blood cortisol levels were…
Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Heidrun Gehlen (firstReferee), Prof. Dr. Corinna Eule (furtherReferee), Univ.-Prof. Dr. Rudolf Staufenbiel (furtherReferee).
Subjects/Keywords: respiratory system; horses; physiology; exercise; endoscopy; stress; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hellauer, A. K. (2014). Effect of different head-neck-positions on endoscopic findings of the upper
airway tract and on stress associated parameters in the ridden horse. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8715
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hellauer, Andrea Karin. “Effect of different head-neck-positions on endoscopic findings of the upper
airway tract and on stress associated parameters in the ridden horse.” 2014. Thesis, Freie Universität Berlin. Accessed April 22, 2021.
http://dx.doi.org/10.17169/refubium-8715.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hellauer, Andrea Karin. “Effect of different head-neck-positions on endoscopic findings of the upper
airway tract and on stress associated parameters in the ridden horse.” 2014. Web. 22 Apr 2021.
Vancouver:
Hellauer AK. Effect of different head-neck-positions on endoscopic findings of the upper
airway tract and on stress associated parameters in the ridden horse. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Apr 22].
Available from: http://dx.doi.org/10.17169/refubium-8715.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hellauer AK. Effect of different head-neck-positions on endoscopic findings of the upper
airway tract and on stress associated parameters in the ridden horse. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-8715
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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