subject:(600 Technik Medizin angewandte Wissenschaften 610 Medizin und Gesundheit 610 Medizin und Gesundheit)

Freie Universität Berlin

1. Gum, Franz. Development and verification of a system for respiration triggered treatments within the field of highly conformal radiation therapy.

Degree: 2010, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/11834

► Since the 1950s lung cancer is the type cancer with the highest mortality rate and causes more deaths than the next three most frequent types… (more)

▼ Since the 1950s lung cancer is the type cancer with the highest mortality rate and causes more deaths than the next three most frequent types of cancer together. One of the main problems of radiation treatments of lung cancer poses the high mobility of lung tumors due to breathing and heart beat. The tumor motion due to breathing can be as much as 2,5 cm in cranio-caudal direction. So far, methods to address this kind of tumor motion are very insufficient. Because of that large radiation fields are being used to guarantee that the tumor receives the minimal required radiation dose despite of the tumor motion. As a result a large amount of healthy tissue receives radiation, which is especially critical for the radiation sensitive lung tissue. Conventional radiation delivery systems and linear accelerators are up to now not able to solve this fundamental problem. Based on the x-ray and infrared based positioning technology of the Novalis linear accelerator a system for a respiration triggered tumor treatment was developed and brought to clinical routine use. The system is applicable for all indications, which are subject to breathing induced motion with a special focus on lung and liver tumors. Two x-ray tubes with two detectors make it possible to use bony anatomy or implanted markers for patient positioning. The detection of breathing motion by external markers and the correlation to an implanted marker make it possible to predict tumor position and motion based on the motion of the external markers. Using this method it is possible, via the close to real-time information of patient / tumor position, to perform a respiration triggered treatment. The developed concepts and methods were, in a first step, verified on an especially constructed gating phantom. In a second step the system was used for patient treatments to verify clinical usability, achieved accuracy as well potentially achieved clinical gain. The achieved results impressively show the potential of the system. The overall system accuracy to position a moving target is within 1 mm and therefore at an identically high level as the positioning accuracy of the Novalis system for non-moving targets. As shown in comprehensive measurements, gated treatments even allow the application of complex IMRT treatment on a moving target with only little deviation of the applied to the planned dose distribution. The total loss of the planned dose distribution when treating a moving target without gating can be prevented and a homogeneous dose coverage of the tumor as well as best possible protection of critical structures can be restored. The developed gating phantom did prove to be very effective and user friendly, offering functionalities that exceed the requirements for routine quality assurance by far. The clinical usability of the gating system was proven by the completion of this work on more than 20 treated patients with more than 200 treatment fractions. Clinical validation was performed on 19 patients (11 lung, 8 liver) with 23 treated indications and 2649… Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Dr. med. V. Budach (firstReferee), Doz. Dr. D. Georg, Prof. Dr. med. Th. Wendt (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA (6^th Edition):

Gum, F. (2010). Development and verification of a system for respiration triggered treatments within the field of highly conformal radiation therapy. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11834

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gum, Franz. “Development and verification of a system for respiration triggered treatments within the field of highly conformal radiation therapy.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. https://refubium.fu-berlin.de/handle/fub188/11834.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gum, Franz. “Development and verification of a system for respiration triggered treatments within the field of highly conformal radiation therapy.” 2010. Web. 01 Dec 2020.

Vancouver:

Gum F. Development and verification of a system for respiration triggered treatments within the field of highly conformal radiation therapy. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: https://refubium.fu-berlin.de/handle/fub188/11834.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gum F. Development and verification of a system for respiration triggered treatments within the field of highly conformal radiation therapy. [Thesis]. Freie Universität Berlin; 2010. Available from: https://refubium.fu-berlin.de/handle/fub188/11834

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

2. Metz, Martin. Physiological functions of mast cells.

Degree: 2010, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/13391

► For many decades, mast cells are primarily known for their detrimental role in the elicitation of allergic reactions. Although physiological functions have been postulated ever… (more)

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Metz, M. (2010). Physiological functions of mast cells. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Metz, Martin. “Physiological functions of mast cells.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. https://refubium.fu-berlin.de/handle/fub188/13391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Metz, Martin. “Physiological functions of mast cells.” 2010. Web. 01 Dec 2020.

Vancouver:

Metz M. Physiological functions of mast cells. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: https://refubium.fu-berlin.de/handle/fub188/13391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Metz M. Physiological functions of mast cells. [Thesis]. Freie Universität Berlin; 2010. Available from: https://refubium.fu-berlin.de/handle/fub188/13391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

3. Weise, Mirjam. Neurodegeneration in newborn rats following propofol anesthesia.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6072

► Recently, it has been shown that the combined application of GABA-enhancing and NMDA-blocking agents (midazolame, nitrous oxide and isoflurane) induces widespread neurodegeneration in the brains… (more)

▼ Recently, it has been shown that the combined application of GABA-enhancing and NMDA-blocking agents (midazolame, nitrous oxide and isoflurane) induces widespread neurodegeneration in the brains of newborn rats. Propofol (6,2 Diisopropylphenol) acts via GABAA agonism as well as NMDA antagonism. The use of propofol 1% for induction and maintenance of anesthesia is approved in Germany for children older than 1 month. Despite of these restrictions off- label use is common for anesthesia even in preterm infants and neonates. Three to 21 day old Wistar rats received intraperitoneal injections with various dosages of propofol and were separated from their mother during the experimental phase. In every litter animals were randomized either for anesthesia or controls. To maintain body temperature and prevent hypothermia, animals were placed on a heating device. During anesthesia respiratory frequency and skin color were observed to detect apnoea and hypoxia. Verum and control animals received injections of PÄD II (crystalloid/glucose solution) preventing hypoglycemia and hypovolemia. Control animals were separated from their mother for the same period. After anesthesia animals were observed for another 90 min until they were awake enough to be returned to their mother. Animals were killed for perfusion and fixation with an injection of an overdose of chloral hydrate 24 h after starting anesthesia. Brains were examined histopathologically using the De Olmos cupric silver staining. Degenerating cells were determined in sections of 17 different parts of the brain by a stereological dissector. Additionally, a summation score of the density of apoptotic cells was calculated for every brain. Six-day-old rats received propofol doses of 30 mg/kg body weight every 90 min up to a cumulative dose of 90 mg/kg. Compared to controls the brains showed a significant higher neurodegenerative summation score. Additionally a dose dependent effect could be demonstrated. The six-day-old rats receiving 3 x 20 mg propofol per kg body weight showed no difference in the neurodegeneration comparised with the controls. The dosage of 3 x 10 mg propofol per kg body weight causes a significant lower neurodegenerative summation score compared to controls. Furthermore an age dependency has been demonstrated. Those six- day-old rats receiving 30 mg/kg body weight every 90 min up to a cumulative dose of 90 mg/kg, showed a significant higher neurodegenerative summation score when compared to controls. The 21 day old rats that were treated with 3 x 30 mg propofol per kg body weight showed no difference in the neurodegeneration compared to the controls. The significance of these results for clinical anesthesia has not been completely clarified. Future studies should focus on identification of safe anesthetic strategies for the developing brain. Advisors/Committee Members: n (gender), Priv.-Doz. Dr. med. T. Kerner (firstReferee), Prof. Dr. med. C. Bührer (furtherReferee), Prof. Dr. med. U. X. Kaisers (furtherReferee).

Subjects/Keywords: neurodegeneration; propofol; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Weise, M. (2010). Neurodegeneration in newborn rats following propofol anesthesia. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6072

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weise, Mirjam. “Neurodegeneration in newborn rats following propofol anesthesia.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-6072.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weise, Mirjam. “Neurodegeneration in newborn rats following propofol anesthesia.” 2010. Web. 01 Dec 2020.

Vancouver:

Weise M. Neurodegeneration in newborn rats following propofol anesthesia. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-6072.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weise M. Neurodegeneration in newborn rats following propofol anesthesia. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-6072

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

4. Wohlan, Karolina Anna. Analysis of tumor specific T-cell after hybridcell vaccination at melanoma patients.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12171

► For this work we measured the frequencies of specific T-cells after hybrid cell vaccination of 29 melanoma stage III and IV patients. There is a… (more)

▼ For this work we measured the frequencies of specific T-cells after hybrid cell vaccination of 29 melanoma stage III and IV patients. There is a lot of research about immune therapies against malignant melanoma. Amongst others there are studies with autologous, allogeneic or peptide vaccines. In this case we extracted tumour materials to produce an autologous vaccine, which we fusioned with donored dendritic cells. This kind of vaccine shall expose the immune system of the patient again with the tumour antigens to induce an immune reaction. Focus of this immune response are tumour-specific cytotoxic T-cells, which are considered to be the major effector cells of the anti- tumour immune response. The frequencies of these tumour specific T-cells are measured by FACS analysis before vaccination, and 24h and 48h afterwards, respectively. The first three vaccination cycles have been evaluated. Additionally different injection spots and differing amounts of injected hybrid cells are compared to each other. Moreover the question came up, if there is a correlation between the clinical disease development of the individual patients. After stimulation of single tumour antigens partly frequencies of the specific T-cells in the range of 0,01% - 8% had been metered, partly specific T-cells could not be verified. Depending on the patient HLA-A2 or HLA-A1 restricted tumour antigens had been examined. A correlation with clinical disease development could not be recognised. Nor have there been a relevant difference in choosing a certain injection spot or a certain amount of injected cells. This work illustrates, that one is still trying to understand and to improve the respective immune therapies against malignant melanoma. One part of the above is the analysis of the therapeutic induced immune response, e.g., the frequency determination of induced T-cell. Advisors/Committee Members: [email protected] (contact), n (gender), Priv. Doz. Dr. med. U. Trefzer (firstReferee), Prof. Dr. med. K. Possinger (furtherReferee), Prof. Dr. med. E. Späth-Schwalbe (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wohlan, K. A. (2010). Analysis of tumor specific T-cell after hybridcell vaccination at melanoma patients. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wohlan, Karolina Anna. “Analysis of tumor specific T-cell after hybridcell vaccination at melanoma patients.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-12171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wohlan, Karolina Anna. “Analysis of tumor specific T-cell after hybridcell vaccination at melanoma patients.” 2010. Web. 01 Dec 2020.

Vancouver:

Wohlan KA. Analysis of tumor specific T-cell after hybridcell vaccination at melanoma patients. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-12171.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wohlan KA. Analysis of tumor specific T-cell after hybridcell vaccination at melanoma patients. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-12171

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

5. Claessen, Björn. Clinical evaluation and quantitative margin analysis of anterior composite resin restorations placed in student courses after six years.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13205

► At 102 randomly chosen patients from the Charité-Universitätsmedizin Berlin Dental School, Campus Virchow-Klinikum, one anterior composite resin restoration each were evaluated after 6,2 ±1 years… (more)

▼ At 102 randomly chosen patients from the Charité-Universitätsmedizin Berlin Dental School, Campus Virchow-Klinikum, one anterior composite resin restoration each were evaluated after 6,2 ±1 years by two dentists, who were calibrated by BLUNCK. From these 102 restored teeth, 10 teeth (10,2 %) received a prosthetic treatment within the 6 years. Two teeth were extracted because of periodontal reasons. Three fillings (3 %) were replaced within the time of 6 years and one was lost. Therefore, 86 teeth were evaluated by using modified RYGE-criteria. Finally, 80 restorations were included into the statistical evaluation, because only those were placed by using OptiBond FL in combination with Herculite XR as a restorative material. From these 80 restorations, 67 were also evaluated by the quantitative margin analysis in a scanning electron microscope (SEM). The results showed that 96 % of the evaluated anterior restorations placed with a hybrid composite resin, were still in situ. With only few exceptions (5 %) the patients did still agree with the aesthetics of the restorations after 6 years. Class IV restorations showed a statistically significant higher loss of incisal edges and chipping. The quantitative margin analysis revealed statistically significant higher amounts of “continuous margins” at restorations placed under rubberdam compared to those restorations which were applied without using it. A statistically significant higher percentage of gap formation was found at Class IV compared to Class III restorations. There was also a significantly higher amount of gap formation at both cavity classes when the cervical margin was located in dentin or in enamel with a thickness less than 0.5 mm. The clinical inspection by a practicing dentist using probe and mirror can hardly detect gaps at the restoration’s margins. Marginal staining occurred statistically significantly more often at margins which have been categorised by the margin analysis as “overhangs” and even as “continuous margins”. From the result of this study it can be concluded that rubberdam is mandatory in order to increase the amount of perfect margins. The cervical margin in dentin or in areas with rather thin remaining enamel increases the risk for gap formation as well as reconstructions of incisal edges in comparison to anterior restorations without incisal extension. Marginal staining is not necessarily a reason for replacing a restoration because it does not definetely mean gap formation. Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Fr. J.-F. Roulet (firstReferee), Naumann, Priv.-Doz. Dr. W.-D. Müller, Priv.-Doz. Dr. A (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Claessen, B. (2010). Clinical evaluation and quantitative margin analysis of anterior composite resin restorations placed in student courses after six years. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13205

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Claessen, Björn. “Clinical evaluation and quantitative margin analysis of anterior composite resin restorations placed in student courses after six years.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-13205.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Claessen, Björn. “Clinical evaluation and quantitative margin analysis of anterior composite resin restorations placed in student courses after six years.” 2010. Web. 01 Dec 2020.

Vancouver:

Claessen B. Clinical evaluation and quantitative margin analysis of anterior composite resin restorations placed in student courses after six years. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-13205.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Claessen B. Clinical evaluation and quantitative margin analysis of anterior composite resin restorations placed in student courses after six years. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-13205

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

6. Lux, Romy. Glutamate-uptake and -release by astrocytes after treatment with Clostridium botulinum C3-Proteine.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7586

► In the present paper the influence of Clostridium botulinum C3-protein on the glutamate uptake and release in cultivated mice-astrocytes was determined. First of all the… (more)

▼ In the present paper the influence of Clostridium botulinum C3-protein on the glutamate uptake and release in cultivated mice-astrocytes was determined. First of all the results of previous works on the influence of C3bot on astrocyte morphology and the associated decrease of RhoA-proteinlevels could have been validated. In C3bot-treated cultures a significant increase of the uptake of tritium-labelled Glutamate could have been measured. The following studies of the glutamate-transporters showed that the expression of transporter GLT-1 was increased significantly and the expression of GLAST was rarely affected. Pharmacological studies could verify, that the increase in glutamate-uptake relies on the activity of this transporter. Furthermore it was shown that also vesicular glutamate transporters such as VGLUT1-3 were expressed, but not influenced by C3bot in the analyzed cultures. Despite this the increased inhibition of glutamate uptake by bafilomycinA1 after C3bot- treatment suggests an involvement of vesicular storage processes. The C3bot- treatment also led to an increase of Ca2+-dependent secretion, as shown with the Ca2+-Ionophore Ionomycin. In further studies a significantly increased expression of SNARE-protein Synaptobrevin could have been demonstrated. Visualization and quantification of vesicular fusion events with the plasma membrane via AM1-43 dye supplied evidence of augmented numbers of these events after treatment with C3bot. These indications of increased exocytotic glutamate release were confirmed via Clostridium botulinum Neurotoxin D, which could block most of the C3bot-associated release. The conducted experiments proved a determing role for Rho-proteins in regulation of uptake and release of the most important excitatory transmitter and therefor also for the whole glutamate-homeostasis in the CNS. They also suggest that previous shown effects of C3bot-proteins on neuronal growth could possibly also rely on indirect-mediated, glial effects. Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Dr. G. Ahnert-Hilger (firstReferee), Prof. Dr. H. Bigalke (furtherReferee), Prof. Dr. C. Beyer (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lux, R. (2010). Glutamate-uptake and -release by astrocytes after treatment with Clostridium botulinum C3-Proteine. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7586

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lux, Romy. “Glutamate-uptake and -release by astrocytes after treatment with Clostridium botulinum C3-Proteine.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-7586.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lux, Romy. “Glutamate-uptake and -release by astrocytes after treatment with Clostridium botulinum C3-Proteine.” 2010. Web. 01 Dec 2020.

Vancouver:

Lux R. Glutamate-uptake and -release by astrocytes after treatment with Clostridium botulinum C3-Proteine. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-7586.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lux R. Glutamate-uptake and -release by astrocytes after treatment with Clostridium botulinum C3-Proteine. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-7586

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

7. Niehues, Stefan Markus. Application of computed tomography volume datasets with combined 2D and 3D reconstructions in animal experiments reflecting the 3R concept.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5259

► This habilitation thesis investigated how the use of computed tomography (CT) with subsequent 2D and 3D reformations can contribute in animal experiments and to the… (more)

▼ This habilitation thesis investigated how the use of computed tomography (CT) with subsequent 2D and 3D reformations can contribute in animal experiments and to the 3R concept in terms of reduction, refinement and replacement. Especially computed tomographic scans have a high value in the comprehensive analysis of animal experimental projects due to the short acquisition time. The low-risk imaging of the animal by CT and postprocessing of the acquired volume data sets make it possible to answer questions even far beyond the initial question. The habilitation thesis presented here demonstrates the value of CT for animal studies and especially in the areas of replacement, reduction and refinement according to the 3R principles of Russell and Burch: We could detect pulmonary changes on CT representing influence of non- physiological positioning on lung perfusion and ventilation (see page 13). Also we were able to image the reasons for limitations of veno-venous hemofiltration and present alternatives (see page 23). For refinement of the animal model "Minipig" the central vessels were measured in vivo by CT at different time points and then correlated to histology. For the first time a data pool was generated, which -without restriction of fixation and shrinkage- is comparable to what will be encountered during surgery or interventional procedures (see page 35). Furthermore, the influence of weight and growth on the vascular system of minipigs aged between 16-20 months could be relativized. The evaluation of a vein cuff, which has been tested according its position, function and biocompatibility, was done exclusively on CT data sets. With the help of CT most of the questions could be answered during the course of the trial without killing the animals. The aspect of reduction (less animals) was successfully implemented here (see page 40). Two aspects of physiological and pathophysiological changes were successfully represented by means of computed tomographic volume data sets : It has been shown that -and how- a complete occlusion of the aorta can be completely compensated without clinical symptoms in female domestic pigs due to specific collaterals (see page 51). Finally, the concept of the critical defect size was called into question observating bone defects in the mandible of minipigs. Different defect sizes far beyond the size considered as critical showed extensive new bone formation in CT and in volumetric assessment (see page 65). At the same time the limitations of an animal model and the consequences were addressed in this study. The knowledge gained here can be used to prevent experimental projects, as these data shows once again that a well-established animal models need to be examined further because of insufficient physiological description. Additionally, a pool of data acquired from all studies in domestic pigs and minipigs enables further evaluation with new questions and without further scans or measurements. For example, one given publication did not require any additional animal testing but was based on… Advisors/Committee Members: m (gender), Herr Prof. Dr. R. H. Tolba/Aachen (firstReferee), Herr Prof. Dr. F. Wacker/Hannover (furtherReferee).

Subjects/Keywords: computertomography; 3R; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Niehues, S. M. (2014). Application of computed tomography volume datasets with combined 2D and 3D reconstructions in animal experiments reflecting the 3R concept. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5259

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Niehues, Stefan Markus. “Application of computed tomography volume datasets with combined 2D and 3D reconstructions in animal experiments reflecting the 3R concept.” 2014. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-5259.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Niehues, Stefan Markus. “Application of computed tomography volume datasets with combined 2D and 3D reconstructions in animal experiments reflecting the 3R concept.” 2014. Web. 01 Dec 2020.

Vancouver:

Niehues SM. Application of computed tomography volume datasets with combined 2D and 3D reconstructions in animal experiments reflecting the 3R concept. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-5259.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Niehues SM. Application of computed tomography volume datasets with combined 2D and 3D reconstructions in animal experiments reflecting the 3R concept. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-5259

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

8. Bilang, Dominique. Validation of common classification systems for assessing the mineralization of third molars.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7332

► One major criterion for dental age estimation is the evaluation of third molar mineralization.There are various methods for evaluating tooth mineralization based on classification by… (more)

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Bilang, D. (2010). Validation of common classification systems for assessing the mineralization of third molars. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7332

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bilang, Dominique. “Validation of common classification systems for assessing the mineralization of third molars.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-7332.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bilang, Dominique. “Validation of common classification systems for assessing the mineralization of third molars.” 2010. Web. 01 Dec 2020.

Vancouver:

Bilang D. Validation of common classification systems for assessing the mineralization of third molars. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-7332.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bilang D. Validation of common classification systems for assessing the mineralization of third molars. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-7332

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

9. Kähne, Andreas. Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusions.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5016

► Blood transfusion may induce autoimmune hemolytic anemia (AIHA) that may in some instances be severe.1-6 In addition, 32 percent (weighted mean) of patients with autoantibodies… (more)

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Kähne, A. (2010). Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusions. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5016

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kähne, Andreas. “Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusions.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-5016.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kähne, Andreas. “Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusions.” 2010. Web. 01 Dec 2020.

Vancouver:

Kähne A. Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusions. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-5016.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kähne A. Coexistence of autoantibodies and alloantibodies to red blood cells due to blood transfusions. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-5016

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

10. Kunkel, Oliver. Cardiovascular risk assessment with simple anthropometric parameters.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8815

► For the evaluation of overweight and obesity and the risk assessment for complications various anthropometric methods are in discussion - such as body mass index,… (more)

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Kunkel, O. (2010). Cardiovascular risk assessment with simple anthropometric parameters. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8815

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kunkel, Oliver. “Cardiovascular risk assessment with simple anthropometric parameters.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-8815.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kunkel, Oliver. “Cardiovascular risk assessment with simple anthropometric parameters.” 2010. Web. 01 Dec 2020.

Vancouver:

Kunkel O. Cardiovascular risk assessment with simple anthropometric parameters. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-8815.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kunkel O. Cardiovascular risk assessment with simple anthropometric parameters. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-8815

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

11. Torres Suárez, Elena. Near-infrared autofluorescence in patients with age-related macular degeneration.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11187

► The confocal scanning laser ophthalmoscope (HRA-2) records the autofluorescence of the RPE lipofuscin and RPE melanin using the fundus autofluorescence (FAF) technique and the near-infrared… (more)

▼ The confocal scanning laser ophthalmoscope (HRA-2) records the autofluorescence of the RPE lipofuscin and RPE melanin using the fundus autofluorescence (FAF) technique and the near-infrared autofluorescence (NIA) technique, respectively. The aim of this prospective study is to collect and analyse retinal images of patients with exudative ARMD obtained with four different imaging techniques. Colour fundus photographs, early and late phase fluorescein angiography (eFFA and lFFA) images, FAF images and NIA images of 83 eyes of 74 patients were registered and analysed regarding different characteristics of the visible lesions. Further goals are to develop a classification of the NIA changes and to identify NIA patterns related to the visual outcome. Six different NIA patterns were described in patients with exudative ARMD: „branching“, „geographic“, „ring“, „speckled“, „banded“ and „speckled+banded“. The difference in the areas of corresponding lesions measured with lFFA, FAF and NIA was not statistically significant. However, in patients with small changes the NIA area of the lesions was bigger than the corresponding FAF area. Therefore, the NIA could be especially adequate to evaluate early exudative changes in ARMD. The patterns „branching“ and „banded“ had the highest and lowest visual acuity in the initial examination, respectively. The patterns „speckled+banded“ and „geographic“ achieved respectively the highest and lowest visual increase after anti-VEGF therapy. Eyes with a central decreased NIA intensity showed a worse visual increase after anti-VEGF than patients with a normal central NIA. The differences between the FAF and NIA findings suggest that they can provide independent information about RPE integrity, which is necessary to understand the pathophysiology of ARMD and to identify new prognostic factors. Advisors/Committee Members: n (gender), Prof. Dr. med. U. Kellner (firstReferee), Prof. Dr. med K. Rüther (furtherReferee), Priv.-Doz. Dr. med. J. Wachtlin (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Torres Suárez, E. (2010). Near-infrared autofluorescence in patients with age-related macular degeneration. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11187

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Torres Suárez, Elena. “Near-infrared autofluorescence in patients with age-related macular degeneration.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-11187.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Torres Suárez, Elena. “Near-infrared autofluorescence in patients with age-related macular degeneration.” 2010. Web. 01 Dec 2020.

Vancouver:

Torres Suárez E. Near-infrared autofluorescence in patients with age-related macular degeneration. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-11187.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Torres Suárez E. Near-infrared autofluorescence in patients with age-related macular degeneration. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-11187

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

12. Mönter, Nerida. Blood gas values, anamnestic and clinical results at an umbilical artery pH < 7.00.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11019

► The purpose of this study was to investigate the causes and consequences of a severe acidosis of the newborn and to correlate umbilical blood gas… (more)

▼ The purpose of this study was to investigate the causes and consequences of a severe acidosis of the newborn and to correlate umbilical blood gas parameters with indicators of early morbidity and neonatal death. This retrospective study was based on the review of maternal and neonatal charts of 71 infants who were born from 01/2000-06/2006 with an umbilical artery pH below 7.0, and a control group of the same size. The relationship between umbilical artery pH, standard base excess, standard bicarbonate and lactate on one side and variables of delivery and the neonatal period on the other side was determined. Most of the newborns had a mixed acidemia with a metabolic component. Whereas for the term infants it seemed as if prenatal alterations were the main cause for the development of a severe acidosis, acute birth complications, such as placental abruptions, were the most common cause for the preterm infants. The rate of emergency caesarean section was significantly higher in the acidosis group than in the control group for both term and preterm infants. Neonatal morbidity was higher in the acidosis group. The rates of intubation, admission to the Neonatal Intensive Care Unit (NICU) and neurological complications were higher, while apgar values were lower than in the control group. There were two neonatal deaths, in both cases the umbilical artery pH was 6.54, the lowest value recorded in this study. The umbilical blood gas parameters of the term newborns correlated significantly with the neonatal complications. Especially low pH and base excess were powerful indicators and showed a correlation with low apgar values, rate and duration of intubation, duration in the NICU and rate of neurological complications and neonatal deaths. For the preterm infants the most powerful parameter was lactate levels, which correlated with the rate of neurological complications. In this study bicarbonate levels were less useful than expected, probably because of the incomplete dataset on bicarbonate. With this study it is not possible to make any conclusions for the long-term sequelae after a severe acidosis. It is known that the majority of acidotic newborns have no later sequelae. In contrast, if neurological seizures occur during the neonatal period after a sever acidosis it makes long-term sequelae more probable. The aim of modern obstetrics should be to aspire to the birth of a vital nonacidotic newborn because the short-term and long-term morbidity is significant higher after a severe acidosis. Advisors/Committee Members: n (gender), Prof. Dr. med. Klaus Vetter (firstReferee), Prof. Dr. med. J. W. Dudenhausen (furtherReferee), Prof. Dr. med. KTM Schneider (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Mönter, N. (2010). Blood gas values, anamnestic and clinical results at an umbilical artery pH < 7.00. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11019

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mönter, Nerida. “Blood gas values, anamnestic and clinical results at an umbilical artery pH < 7.00.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-11019.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mönter, Nerida. “Blood gas values, anamnestic and clinical results at an umbilical artery pH < 7.00.” 2010. Web. 01 Dec 2020.

Vancouver:

Mönter N. Blood gas values, anamnestic and clinical results at an umbilical artery pH < 7.00. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-11019.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mönter N. Blood gas values, anamnestic and clinical results at an umbilical artery pH < 7.00. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-11019

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

13. El-Mahmoud, Sana. Evaluation of the value of cardiovascular magnetic resonance imaging in clinical cardiology.

Degree: 2016, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4369

► Background The importance of cardiovascular magnetic resonance (CMR) imaging is growing, particularly in the diagnosis of cardiomyopathy, myocarditis and in the assessment of ischemic heart… (more)

▼ Background The importance of cardiovascular magnetic resonance (CMR) imaging is growing, particularly in the diagnosis of cardiomyopathy, myocarditis and in the assessment of ischemic heart disease. Compared to alternative modalities, CMR is a minor contributor which is particularly explained by the limited access and initial investment. The integration of CMR in the training curriculum of cardiologists may indicate that the application of CMR will grow in future. At this time, only few is known about the value of CMR compared with alternative modalities and about the application of CMR in everyday clinical use. The present study aimed at providing descriptive data about the clinical use of CMR in a institution of CMR. We also aimed at analysing the value of CMR in cardiological diagnostics and the impact on patient management. Methods All clinically indicated CMR exams were registered during one year. Detailed data of the individual patient as well as procedural information of each exam were collected. Furthermore a subgroup of 250 cases, was evaluated by an external reviewer and the influence of CMR on patient management and the need for further diagnostic testing was estimated. Results 2598 patients were included in the analysis. The most frequent indication for CMR was the assessment of inflammatory (31,3%) and ischemic (28,4%) heart disease. 75,9% patients received a gadolinium-based contrast media. The majority of all exams did not last longer than 45 minutes (81,1%). Anxiolytic sedation was needed in 3.8%. The majority of studies provided diagnostic image quality (99,6%). 98% of all studies were properly terminated. During the studies, no severe adverse events occurred. In over 98% cases of all exams, the clinical question was answered. CMR was conduced to rule out a suspected diagnosis (67,4%), verified a suspected diagnosis (34,9%), and in 21,4% a new, unexpected diagnosis could be received. Before undergoing CMR, 80,4% of all patients had undergone at least one alternative diagnostic test, mainly transthoracic echocardiography (43%). In the subgroup analysis, the impact of CMR influenced the requirement of further cardiac daignostic testing and the amount of patients, who were initially referred to hospital admission. From the perspective oft the reviewer, the clinical question was answered completely in 88,4% of all cases. Conclusion CMR is a safe and robust technique that is clinically applicated in a wide variety of indicaitions. The application of CMR might profitably influence individual patient management. Advisors/Committee Members: [email protected] (contact), w (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: cmr; evaluation; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

El-Mahmoud, S. (2016). Evaluation of the value of cardiovascular magnetic resonance imaging in clinical cardiology. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4369

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

El-Mahmoud, Sana. “Evaluation of the value of cardiovascular magnetic resonance imaging in clinical cardiology.” 2016. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-4369.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

El-Mahmoud, Sana. “Evaluation of the value of cardiovascular magnetic resonance imaging in clinical cardiology.” 2016. Web. 01 Dec 2020.

Vancouver:

El-Mahmoud S. Evaluation of the value of cardiovascular magnetic resonance imaging in clinical cardiology. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-4369.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

El-Mahmoud S. Evaluation of the value of cardiovascular magnetic resonance imaging in clinical cardiology. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-4369

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

14. Mausolf, Magdalena. Vascular properties during hemodialysis – differences in reflective qualities.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4566

► In the present research study we determined hemodynamic parameters in patients with end stage renal disease during hemodialysis by non invasive monitoring, using digital photoplethysmography… (more)

▼ In the present research study we determined hemodynamic parameters in patients with end stage renal disease during hemodialysis by non invasive monitoring, using digital photoplethysmography and applanation tonometry. In addition we measured electrolyte concentration before and after hemodialysis. The digital volume pulse was registered continuously during hemodialysis in 104 patients by digital photoplethysmography. We calculated the reflective index using the diastolic decay of the digital volume pulse as a measure of reflective properties. At the start of hemodialysis there was a significant correlation between reflective index and age (Spearman rs = 0,25, p = 0,01), that means with advancing age reflective properties increase. In 28 patients there was a decrease of the reflective index during hemodialysis (from 35,8 ± 1,9 to 34,5 ± 1,5, p = 0,28), we called this the dip group. In 76 patients there was a significant increase of the reflective index from 33,2 ± 1,1 to 36,2 ± 1,1, p= 0,06; we called this the increase group. Analysis of both groups by receiver operator characteristic curve showed the posibility of distinguishing each group from one another by measuring potassium concentration before each hemodialysis session (AUC = 0,68; p = 0,09). In concrete terms this means with increasing potassium concentration at the beginning of hemodialysis one has to expect a decrease of the reflective index during hemodialysis. Further more, heart rate at the end of hemodialysis was significantly higher in the dip group in contrast to the increase group (83 ± 3 beats per minute vs. 77 ± 2 beats per minute; p < 0,05). This is most likely due to a compensation mechanism in reaction to the impairment of the reflective properties. By digital phothoplethysmography we registered flow mediated vasodilation before and after hemodialysis. In both groups there was no significant change; the reflective index did not decrease below starting values. By non invasive applanation tonometry we registered compliance of large arteries in both groups. In the dip group there was a significant decrease of compliance of large arteries from 14,0 ± 1,7 ml/mmHg at the start to 9,1 ± 0,9 ml/mmHg at the end of hemodialysis (p = 0,028). In contrast to that compliance of large arteries did not change significantly during hemodialyses in the increase group. The present research study defines different patterns of hemodynamic reactions during hemodialyses. It shows those changes are directly related to potassium concentration at the start of hemodialysis. Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Dr. med. M. Tepel (firstReferee), Priv.-Doz. Dr. med. B. Henning, Prof. Dr. med. C. Doberauer (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mausolf, M. (2010). Vascular properties during hemodialysis – differences in reflective qualities. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4566

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mausolf, Magdalena. “Vascular properties during hemodialysis – differences in reflective qualities.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-4566.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mausolf, Magdalena. “Vascular properties during hemodialysis – differences in reflective qualities.” 2010. Web. 01 Dec 2020.

Vancouver:

Mausolf M. Vascular properties during hemodialysis – differences in reflective qualities. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-4566.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mausolf M. Vascular properties during hemodialysis – differences in reflective qualities. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-4566

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

15. Fink, Katharina. the olfactory bulbectomized mouse.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6638

► The bilateral ectomy of the olfactory bulb in rats and mice is an accepted animal model of depression. Because of its good predictive validity it… (more)

▼ The bilateral ectomy of the olfactory bulb in rats and mice is an accepted animal model of depression. Because of its good predictive validity it is used to develop new antidepressants and to prove their effectiveness. After the olfactory bulbectomy, the animals show a certain pattern of changes in behaviour and in neurochemical, neuroendocrinological and neuroimmunological parameters. The leading parameter for the changes of behaviour in these animals is the locomotoric hyperactivity in the brightly illuminated open field test. The neurotrophin hypothesis of depression postulates that the signal cascade of neurotrophic factors is disturbed. Particularly BDNF is given a prominent role in the following. It is known that BDNF appears broadly distributed in the brain and that it is of importance for the differentiation and survival of neurons. Several studies show that the Depressive Episode is accompanied by a down regulation of the BDNF levels, by disturbances in the plasticity and by reductions in the hippocampus volume. Animal experiments have been used to attempt to prove the connection between depression and the neurotrophin signal cascade. The results of previous investigations are conflicting and do not allow any certain conclusions to be drawn. The purpose of this work has been to analyse the concentrations of the neurotrophins BDNF and NGF in the brains of olfactory bulbectomized mice used as an animal model of depression for the first time. The success of the bulbectomy is verified by the examination of the locomotion. In five different brain regions that are seen as relevant for depression - hippocampus, frontal cortex, hypothalamus, striatum and parietal cortex - we investigated the levels of the two neurotrophins - BDNF and NGF - in mice with bilateral ectomy of the olfactory bulb and in control animals. For the determination of the protein concentrations we used a highly sensitive two site ELISA. 16 days after the olfactory bulbectomy, we measured higher BDNF levels in the hippocampus and frontal cortex and higher NGF levels in the hippocampus in bulbectomized mice compared to sham mice. Thereby, the BDNF concentrations were augmented in two of the brain regions in the bulbectomized mice, in contrast to the initial assumption. The results in this animal experiment do not give any support for the neurotrophin hypothesis. Reasons for this increase in neurotrophin levels could be, among other things, reparation processes after lesions, hyperactivity during night, reduced breakdown and transport of the protein or the loss of the smelling sense and the associated learning process to reorientate itself. The olfactory bulbectomy in mice has been proposed as an animal model of chronic psychomotoric agitated depression. With respect to the endophenotype concept of depression BDNF does not play a significant role in the pathophysiology of depression in this animal model of depression. Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Dr. med. R. Hellweg (firstReferee), Priv.-Doz. Dr. med. habil. M.-Chr. Jockers-Scherübl, Prof. Dr. J.-P. Voigt (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Fink, K. (2010). the olfactory bulbectomized mouse. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6638

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fink, Katharina. “the olfactory bulbectomized mouse.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-6638.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fink, Katharina. “the olfactory bulbectomized mouse.” 2010. Web. 01 Dec 2020.

Vancouver:

Fink K. the olfactory bulbectomized mouse. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-6638.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fink K. the olfactory bulbectomized mouse. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-6638

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

16. Meyer-Hilse, Frank. Identification of the mixed Dicleotide-Polyphosphate Adenosine-Guanosine- Triphosphate from bovine suprarenal gland.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11810

► The genesis of essential hypertension still is not not sufficiently understood. There is a huge number of different studies to investigate the causes of the… (more)

▼ The genesis of essential hypertension still is not not sufficiently understood. There is a huge number of different studies to investigate the causes of the high blood pressure and to identify the etiology which influence the blood pressure. In this conjunction dinucleotide-polyphosphates and in particular diadenosine-polyphosphates were described. In this study a procedure is introduced to isolate the substance adenosine-guanosine- triphosphate from bovine adrenal gland tissue. In the first step, with the help of an approved procedure, a homogenate of pure bovine adrenal gland tissue was assembledand and then submitted to different chemical-physical processing steps. In a preparative reversed-phase-chromatography a separation of highly hydrophilic and hydrophobic substances was achieved. Afterwards the eluate was further fractionated in the dimensions exclusion-chromatography with regard to the molecular size. In the next step an affinity-chromatography followed with phenylic boronic acid by which dinucleotide-polyphosphates could be separated from mononucleotide-polyphosphates. The result of the affinity- chromatography was further fractionated by means of a displacement- chromatography. In the analytic ion-exchange-chromatography the nucleotide with several phosphate teams were isolated. Finally followed by the analytic reversed-phase-chromatography for further separation of minor components. The fractions of the analytic reversed-phase-chromatography were analysed with MALDI-mass-spectrometry. A molecular mass of 772.9 was detected. A study with synthetically produced adenosine-guanosine-triphosphate and a comparison of the retention times in the Reversed phase column with defaults of known dinucleotide showed a correspondent result. The mass signals measured in the PSD-MALDI-mass-spectrometry could be assigned therefore adenosine-guanosine- triphosphate. By means of enzymatic analytics and followed analytic ion- exchange-chromatography a splitting reaction was ascertained. The masses of two riboses corresponded to those of adenosine and guanosine. These were connected by 1 and 2 phosphate bridges in each case with each other whose phosphoester-connection places were proved in 5' positions of the riboses. It can be gathered that the substance is adenosine-guanosine-triphosphate with the molecules AMP and GDP as well as GMP and ADP. As already mentioned, Adenosine-guanosine-triphosphate influence on the blood pressure regularisation. Further investigations about the occurence of this substance in human tissue may allow conclusions on the genesis of the essential high blood pressure as well as lead to the development of new therapy options in the treatment of the essential high blood pressure. Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Dr. rer. nat. J. Jankowski (firstReferee), Prof. Dr. med. K. Kisters (furtherReferee), Prof. Dr. med. R. Vetter (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Meyer-Hilse, F. (2010). Identification of the mixed Dicleotide-Polyphosphate Adenosine-Guanosine- Triphosphate from bovine suprarenal gland. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11810

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Meyer-Hilse, Frank. “Identification of the mixed Dicleotide-Polyphosphate Adenosine-Guanosine- Triphosphate from bovine suprarenal gland.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-11810.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Meyer-Hilse, Frank. “Identification of the mixed Dicleotide-Polyphosphate Adenosine-Guanosine- Triphosphate from bovine suprarenal gland.” 2010. Web. 01 Dec 2020.

Vancouver:

Meyer-Hilse F. Identification of the mixed Dicleotide-Polyphosphate Adenosine-Guanosine- Triphosphate from bovine suprarenal gland. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-11810.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Meyer-Hilse F. Identification of the mixed Dicleotide-Polyphosphate Adenosine-Guanosine- Triphosphate from bovine suprarenal gland. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-11810

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

17. Groß, Christian. Clinical and radiological comparison of the effect of autologous periosteal cells and autologous iliac crest cancellous bone to the single-level circumferential lumbar fusion.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5408

► Despite modern stabilization techniques and the use of autologous cancellous bone, bone consolidation does not occur in 10–15% of spinal fusion operations. There is also… (more)

▼ Despite modern stabilization techniques and the use of autologous cancellous bone, bone consolidation does not occur in 10–15% of spinal fusion operations. There is also considerable donor site morbidity. Therefore, there is a definite need for material that has a larger measure of osteoinductivity, osteoconductivity, and osteogenic potential. Methods. In this study, 24 patients with degenerative spinal disease underwent single-level circumferential lumbar fusion. The patients were randomly placed in 2 groups, each with different cage filling (Group 1, autologous iliac crest cancellous bone; Group 2, autologous periosteal cells in a fibrin/polyglactin- poly-p-dioxanone fleece). After 3, 6, 9, and 12 months, the patients underwent clinical (Oswestry Disability Index, patient satisfaction, willingness to undergo the operation again, visual analog scale for pain) and radiological (plain and flexion/extension radiographic and thin-layer computed tomography [CT]) examinations. Results. The 6-month CT scans and 9-month radiographs obtained in Group 2 patients showed a significantly higher rate of fusion than those in Group 1 patients. Aside from this, there were no further significant differences. After 12 months, radiographic results showed a fusion rate of 80% in Group 1 and 90% in Group 2. No implant- or transplantrelated complications were observed. Conclusions. The use of autologous periosteal cells on carrier material with osteoinductive and osteoconductive properties showed comparable results with autologous cancellous bone and better results with regard to consolidation at 6–9 months postoperatively. The shorter consolidation time, as well as lower donor site morbidity, justifies the clinical use and further development of this tissue-engineering strategy. Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Dr. med. C. Perka (firstReferee), Prof. Dr.-Ing. G. Bergmann (furtherReferee), Priv.-Doz. Dr. med. U. Liener (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Groß, C. (2010). Clinical and radiological comparison of the effect of autologous periosteal cells and autologous iliac crest cancellous bone to the single-level circumferential lumbar fusion. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5408

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Groß, Christian. “Clinical and radiological comparison of the effect of autologous periosteal cells and autologous iliac crest cancellous bone to the single-level circumferential lumbar fusion.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-5408.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Groß, Christian. “Clinical and radiological comparison of the effect of autologous periosteal cells and autologous iliac crest cancellous bone to the single-level circumferential lumbar fusion.” 2010. Web. 01 Dec 2020.

Vancouver:

Groß C. Clinical and radiological comparison of the effect of autologous periosteal cells and autologous iliac crest cancellous bone to the single-level circumferential lumbar fusion. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-5408.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Groß C. Clinical and radiological comparison of the effect of autologous periosteal cells and autologous iliac crest cancellous bone to the single-level circumferential lumbar fusion. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-5408

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

18. Deckert, P. Markus. Recombinant antibody-enzyme fusion constructs for targeted therapy of colorectal carcinoma.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5701

► Despite the progress made since the 1990s, there is a substantial need for improving the therapy of colorectal carcinoma especially in its metastasized stage. As… (more)

▼ Despite the progress made since the 1990s, there is a substantial need for improving the therapy of colorectal carcinoma especially in its metastasized stage. As 5-fluorouracil remains a central pillar of chemotherapy both in colon and in rectal carcinoma, the improvement of efficacy and tolerability of this drug holds potential for optimizing therapy. The approach followed here is the activation of an essentially non-toxic prodrug in tumor tissue by a bifunctional protein construct that combines the binding properties of a tumor-specific antibody with the catalytic activity of a suitable enzyme. For this concept, termed antibody-directed enzyme-prodrug therapy (ADEPT), here the intestinal gpA33 antigen and the namesake cognate A33 antibody were chosen as the targeting system. After encouraging proof of principle investigations with a methotrexate prodrug to be activated by a chemical conjugate of the complete antibody and carboxypeptidase A, the development of recombinant fusion proteins of a single chain fragment of the A33 antibody with cytosin deaminase isoenzymes from either E. coli oder S. cerevisiae, which convert the in mammals non-toxic antifungal agent 5-fluorocytosine into the cytostatic drug 5-fluorouracil was pursued. The gpA33 protein, which has been classified as an adhesion molecule and novel member of the immunoglobulin superfamily, is expressed in healthy gastrointestinal tissue and in more than 95 % of colorectal carcinomas. As a particularity, it shows a time-dependent specificity for tumor tissue in that it binds initially to the complete gastrointestinal tract, after about two weeks, however, it is only detectable in primary and metastatic carcinoma lesions. The basis for this behaviour as well as the exact biological function of this molecule is not yet fully understood. It has been demonstrated and confirmed here, however, that at least in the cell line LIM 1215 gpA33, after binding of A33 antibody or a fluorescent A33scFv fusion construct, is internalized in microvesicles and resurfaces later. In our studies it could also be demonstrated that the surface expression of gpA33 correlates reproducibly with cell culture confluence and with the cell cycle phase at which a cycle stop was imposed, but not with gpA33 mRNA levels measured at the same time points. These results suggest that gpA33 surface expression is regulated less by control of gene transcription than by intracellular turnover of the internalized antigen. This interpretation is compatible with a signal function of gpA33 in emryonal development as postulated earlier in mice, which may possibly be reactivated in malignantly transformed cells as well as with an adult function in the presentation of antigens the immune presentation of antigens taken up from the intestinal lumen to abluminal cells of the immune system. A major caveat against ADEPT is the immunogenicity of the - mostly non-human - protein components. For enzymes, polyethylen glycol conjugation is a tested way of immunologic "masking". It was unknown whether this method was… Advisors/Committee Members: n (gender), Prof. Dr. rer. nat. Dr. rer. medic. Stefan Barth (firstReferee), Prof. Dr. med. Alexander Knuth (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Deckert, P. M. (2010). Recombinant antibody-enzyme fusion constructs for targeted therapy of colorectal carcinoma. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5701

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Deckert, P Markus. “Recombinant antibody-enzyme fusion constructs for targeted therapy of colorectal carcinoma.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-5701.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Deckert, P Markus. “Recombinant antibody-enzyme fusion constructs for targeted therapy of colorectal carcinoma.” 2010. Web. 01 Dec 2020.

Vancouver:

Deckert PM. Recombinant antibody-enzyme fusion constructs for targeted therapy of colorectal carcinoma. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-5701.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Deckert PM. Recombinant antibody-enzyme fusion constructs for targeted therapy of colorectal carcinoma. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-5701

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

19. Liebner, Matthias. Long-term results from patients after percutaneous transcatheter closure of interatrial communications.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7028

► Percutaneous transcatheter closure of patent interatrial communications after presumed paradoxical embolism is used as an alternative to surgery or long- term anticoagulation for the treatment… (more)

Subjects/Keywords: PFO Migraine; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liebner, M. (2010). Long-term results from patients after percutaneous transcatheter closure of interatrial communications. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7028

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liebner, Matthias. “Long-term results from patients after percutaneous transcatheter closure of interatrial communications.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-7028.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liebner, Matthias. “Long-term results from patients after percutaneous transcatheter closure of interatrial communications.” 2010. Web. 01 Dec 2020.

Vancouver:

Liebner M. Long-term results from patients after percutaneous transcatheter closure of interatrial communications. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-7028.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liebner M. Long-term results from patients after percutaneous transcatheter closure of interatrial communications. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-7028

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

20. Krause-Relle, Katharina. Blood pressure and cardiac phenotype of eNOS-knockout mice with additional overexpression of human endothelin-1.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12114

► Endothelin-1 (ET-1) is an autocrine and paracrine acting peptide hormone, which is mainly produced by endothelial cells of the vasculature.1 It is one of the… (more)

▼ Endothelin-1 (ET-1) is an autocrine and paracrine acting peptide hormone, which is mainly produced by endothelial cells of the vasculature.1 It is one of the most potent vasoconstrictors known so far and acts furthermore as a antiapoptotic, mitogenic, profibrotic and inflammatory agent. ET-1 is released to 80% onto the smooth musculature, where it binds on two G-protein-coupled receptors: the Endothelin-A receptor (ETA-receptor) and the Endothelin-B receptor (ETB-receptor)1. ETA-receptor-activation induces an increase of cytoplasmatic Ca2+, which leads to contraction of the smooth muscle cells.25-29 Surprisingly, animal models with ET-overexpression did not show an increase of arterial blood-pressure, neither ET-1-transgenic mice nor ET-2 -transgenic-rats76, 150, 151. Therefore there must be an activation of antagonistic mechanisms which are able to lower the expression and/or the effects of ET-1. One possible antagonist to ET-activity might be nitric oxide, which is mainly produced in the vasculature by the endothelial nitric oxide synthase (eNOS). NO is a strong vasodilator and is known to downregulate the expression of prepro-ET-mRNA1, 3, 159. To investigate, if eNOS-derived NO is the dominant antagonist of ET-action in the vasculature, we crossbred human- ET-1-transgenic mice with eNOS-knockout-mice. After multiple rebreeding steps, we received four groups: eNOS-/- ET+/+-mice, only eNOS-/-, only ET+/+ and WT (wildtypes) (mice were all homozygous for ET-transgen and/or eNOS-knockout). We wanted to examine, if the imbalance between ET-1 and NO leads to elevated blood pressure, to cardiac and vascular damage and hence to cardiac dysfunction. Blood pressure was assessed via tail-cuff plethysmography, cardiac function by catheterisation of the left ventricle (monitoring of left ventricular pressure during systole and diastole), and the morphology of cardiac tissue and coronary vasculature by histological analysis. Mice with eNOS-knockout (eNOS-/-) only showed an increase in systolic blood pressure and left ventricular hypertrophy with cardiac left ventricular diastolic dysfunction. This phenotype was more promounced in male eNOS-/-. ET-1-overexpressing mice (ET+/+ and eNOS-/-ET+/+) developed a dilated vessel- morphology with a normal media-area but a larger lumen-area and perivascular fibrosis. The combination of and eNOS-knockout and ET-1-overexpression (eNOS-/- ET+/+-mice) led to interstitial cardiac fibrosis, which indicates that there might be a chronic inflammation in the cardiac tissue. eNOS-/- ET+/+-mice furthermore showed significantly higher values for systolic blood pressure compared to eNOS-/- in early generations. In later generations the systolic blood pressure on the same elevated level like eNOS-/-, but was not significantly higher anymore. Although the blood pressure was as elevated as in eNOS-/-, eNOS-/- ET+/+ animals did not develop such pronounced signs of cardiac hypertrophy and a restored cardiac diastolic function. Only the left ventricular end-diastolic pressure was increased, which indicates… Advisors/Committee Members: [email protected] (contact), w (gender), Prof. Dr. Berthold Hocher (firstReferee), Prof. Dr. Florian J. Schweigert (furtherReferee).

Subjects/Keywords: Endothelin; eNOS; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krause-Relle, K. (2010). Blood pressure and cardiac phenotype of eNOS-knockout mice with additional overexpression of human endothelin-1. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12114

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krause-Relle, Katharina. “Blood pressure and cardiac phenotype of eNOS-knockout mice with additional overexpression of human endothelin-1.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-12114.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krause-Relle, Katharina. “Blood pressure and cardiac phenotype of eNOS-knockout mice with additional overexpression of human endothelin-1.” 2010. Web. 01 Dec 2020.

Vancouver:

Krause-Relle K. Blood pressure and cardiac phenotype of eNOS-knockout mice with additional overexpression of human endothelin-1. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-12114.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krause-Relle K. Blood pressure and cardiac phenotype of eNOS-knockout mice with additional overexpression of human endothelin-1. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-12114

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

21. Wachter, Eva. HRV- threshold assessment during bicycle and treadmill in relation to anaerobic thresholds and lactate thresholds.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7957

► Performance diagnosis and measures to control physical strain play a major role in sports and rehabilitation. For that there are used more often methods to… (more)

▼ Performance diagnosis and measures to control physical strain play a major role in sports and rehabilitation. For that there are used more often methods to define heart-rate variability (HRV). The regulation of the heart rate as non stationary signal depends on the autonomic nervous system. Heart rate reflects in the form of beat-to-beat alteration the cardiorespiratory control system. At resting state HRV is in particular subjected to the parasympathetic nervous system and the barorecepter reflex mechanism. During exercise breathing pattern has a relevant effect on HRV. Current studies show that especially the high-frequency components of HRV are associated with respiratory thresholds ( aerob threshold AT and respiratory compensation point RCP). Unlike other studies (Berbalk et al., Horn et al.) that took the fast- Fourier transformation (FFT) for analysis of heart rate variability the present study uses the Hilbert- transformation. That includes the non- stationary pattern of the HRV- signal, contrary to FFT. Requirements of FFT as the analysis of stationary time series are not violated when non-stationary biological signals are present. The Hilbert- transformation transforms time- related, non-stationary data into frequency-related data. Hence obtained spectrum is used to reconstruct respectively to adjust the phase, that means to calculate the imaginary part out of the given real part. There are gained certain dimensions out of these continous variances, for instance the HRV- threshold (THRV) at re-increase of the high-frequency components. At present study comparatively were defined respiratory threshold AT using V-slope method according to Wasserman et al. as lactate thresholds using concepts according to Dickhut et al., Stegman et al. and Mader et al. In that study four different groups were independently examined by means of increasing applied maximal exercise protocols using ergometry on bike and treadmill in regard to heart rate variability- threshold. All conducted examinations showed a high degree of accordance of THRV and AT. The individual lactate thresholds according to Dickhut et al. and Stegman et al. were minimal above the ventilatory threshold AT. The fix 4-mmol- lactate threshold according to Mader et al. as RCP showed clearly a delayed occurrence. Using as well linear regression as Bland-Altman-plots a high positive accordance or rather an acceptable aberration between THRV and AT could be verified. Consequently is to say that THRV is detectable in the range of ventilatory threshold and hence is usable as surrogate of AT. Hence the analysis of THRV might prospectively deliver an easier, non-invasive performance and trainings diagnosis. Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Dr. med. R. Wolff (firstReferee), Prof. Dr. med. K.-M. Baumann (furtherReferee), Priv. Doz. Dr. med. M. Krüll (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wachter, E. (2010). HRV- threshold assessment during bicycle and treadmill in relation to anaerobic thresholds and lactate thresholds. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7957

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wachter, Eva. “HRV- threshold assessment during bicycle and treadmill in relation to anaerobic thresholds and lactate thresholds.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-7957.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wachter, Eva. “HRV- threshold assessment during bicycle and treadmill in relation to anaerobic thresholds and lactate thresholds.” 2010. Web. 01 Dec 2020.

Vancouver:

Wachter E. HRV- threshold assessment during bicycle and treadmill in relation to anaerobic thresholds and lactate thresholds. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-7957.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wachter E. HRV- threshold assessment during bicycle and treadmill in relation to anaerobic thresholds and lactate thresholds. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-7957

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

22. Musci, Michele. New aspects of the surgical therapy for active infective endocarditis.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6502

► Homograft aortic root replacement (ARR) in active infective endocarditis (AIE) with periannular abscess formation shows satisfactory early and long-term results with significantly better survival in… (more)

Subjects/Keywords: endocarditis; surgery; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Musci, M. (2010). New aspects of the surgical therapy for active infective endocarditis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6502

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Musci, Michele. “New aspects of the surgical therapy for active infective endocarditis.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-6502.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Musci, Michele. “New aspects of the surgical therapy for active infective endocarditis.” 2010. Web. 01 Dec 2020.

Vancouver:

Musci M. New aspects of the surgical therapy for active infective endocarditis. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-6502.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Musci M. New aspects of the surgical therapy for active infective endocarditis. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-6502

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

23. Kugler, Andreas. Heel elevation versus Vacoped.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12889

► In the period from January 2001 to early April 2005 74 patients with an Achilles tendon rupture (90% within the first 7 days after the… (more)

▼ In the period from January 2001 to early April 2005 74 patients with an Achilles tendon rupture (90% within the first 7 days after the accident) were surgically treated in the trauma department of the Humboldt Hospital Vivantes. Postoperatively the patients underwent early functional treatment either with a heel elevation in a shoe, or in a Vacoped-shoe in pes equinus position. Because the two groups were not strictly randomized they were initially compared in their requirements. The two groups showed high similarities in their basic premises and no statistically significant differences. Since group assignment was not strictly randomized the overall comparison is descriptive. 68.9% of patients could be re-examined or questioned. The Achilles tendon rupture occurred in 79.5% of patients during recreational sports activity, with football in the first place of causes. Most affected with 77.3% were middle-aged men at about 45 years. After a short cast immobilization around the 3rd to 4th postoperative day patients were equipped with an appropriate device with which they could be early functional treated. None of the patients had a re-rupture until the follow-up examination. The patients were questioned about their device, and patients in the heel elevation group claimed to have a more comfortable device with an easier handling. The Vacoped group who used the device consistently had the advantage of needing the crutches for a shorter time (two to three weeks less) and having a better stability and sense of security when walking. The Vacoped group was able to start sporting activities earlier and to work in average 3.5 weeks sooner than the heel elevation group. In particular the higher proportion of self-employed in the Vacoped group who can not afford a "sickness" may influence the period of the incapability to work and therefore distort the results. In the restoration of the working and sporting capability, the power level, the postoperative pain and wound healing was no difference between the two groups evident. Comparing the results using the Trillat scores in both groups also showed similar results with over 85% "good" or "very good" results. Besides a physical examination including the measuring of ankle joint range of motion and measurement of the leg circumferences the sonographic measurement of the tendon thickness was made. The Vacoped group showed a slightly thicker scarring of the tendon in the corresponding circumference measurement as well as in the ultrasound measurements. The heel elevation group showed a better mobility in the upper ankle joint and a little less muscle atrophy in the lower leg. The groups showed no noticeable difference in the thigh muscle and the measurements of the knee and foot, witch are mainly formed by bony structures. Due to the lower protection against overstretching the risk of re- rupture in the heel elevation group is theoretically higher. Since no re- rupture occurred in both groups the functional and subjective differences were compared. The Vacoped offered better security… Advisors/Committee Members: [email protected] (contact), n (gender), Prof. Dr. med. Dr. h.c. N. P. Haas (inspector), Priv.-Doz. Dr. med. W. Zenker (inspector), Priv.-Doz. Dr. med. R. A. Laun (inspector), Priv.-Doz. Dr. med. R. Letsch (firstReferee), Prof. Dr. med. M. Faensen (furtherReferee), Prof. Dr. med. F. Hahn (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kugler, A. (2010). Heel elevation versus Vacoped. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12889

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kugler, Andreas. “Heel elevation versus Vacoped.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-12889.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kugler, Andreas. “Heel elevation versus Vacoped.” 2010. Web. 01 Dec 2020.

Vancouver:

Kugler A. Heel elevation versus Vacoped. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-12889.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kugler A. Heel elevation versus Vacoped. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-12889

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

24. Graz, Friederike. Evaluation of diagnostic imaging quality of myocardium vascularisation with 64-slice ct considering coronary arteries, coronary arterial and venous bypass grafts and coronary artery stents.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4414

► Coronary artery disease (CAD) is the leading cause of death in developed countries. Until today invasive coronary angiography is the gold standard for localizing stenosis… (more)

▼ Coronary artery disease (CAD) is the leading cause of death in developed countries. Until today invasive coronary angiography is the gold standard for localizing stenosis in patients with suspected myocardial ischemia. Because this test is invasive and has risks one is searching for noninvasive imaging tests to evaluate and define CAD. In the past years multislice computed tomography has emerged to be a robust technique in non-invasive imaging, especially for excluding CAD in patients with low-to intermediate risk (e. g. patients with atypical angina pectoris; patients with suspected CAD and inconclusive findings and complaints). In this study the imaging quality of this new technique was evaluated considering coronary arteries, coronary arterial and venous bypass grafts and coronary artery stents. Retrospectively coronary ct angiography examinations of 131 patients were analysed. In 100 patientes we looked for coronary arteries, in 31 patients we evaluated 29 arterial and 49 venous bypass grafts and we scored 32 coronary artery stents. There often is good image quality of coronary arteries depending on the heart rate. Usually the left coronary artery is better outlined than the right coronary artery due to the anatomic position of the right coronary artery and its larger displacements during the cardiac cycle. Arrhythmia, heartrates > 70 bpm, severe calcifications, respiratory and motion artifacts as well as obesity are various factors which minimize evaluation of coronary arteries with CT. Coronary artery bypass grafts can be accurately assessed by MSCT. It is a reliable visualization to identify bypass stenosis at an early stage. The evaluation of stents is hampered by the occurrence of high-density artifacts caused by the stent struts. In particular stents with a diameter less than 3 mm are difficult to assess. Indications for coronary CT angiography are still discussed. High risk patients for CAD with typical symptoms for ischemia should undergo an invasive coronary angiography because of its possibility for PTCA. It should be discussed whether this imaging test is indicated for low- risk patients because of its high radiation exposure. Consequently coronary CT angiography seems to be most relevant for intermediate-risk patients because with its high negative predictive value (95%) it can effectively rule out obstructive CAD. In the future this new technique may serve as a gatekeeper function for invasive coronary angiography. Advisors/Committee Members: n (gender), Priv.-Doz. Dr. med. R. Röttgen (firstReferee), Priv.-Doz. Dr. med. O. Dudeck, Prof. Dr. med. K.-T. Hoffmann (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Graz, F. (2010). Evaluation of diagnostic imaging quality of myocardium vascularisation with 64-slice ct considering coronary arteries, coronary arterial and venous bypass grafts and coronary artery stents. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4414

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Graz, Friederike. “Evaluation of diagnostic imaging quality of myocardium vascularisation with 64-slice ct considering coronary arteries, coronary arterial and venous bypass grafts and coronary artery stents.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-4414.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Graz, Friederike. “Evaluation of diagnostic imaging quality of myocardium vascularisation with 64-slice ct considering coronary arteries, coronary arterial and venous bypass grafts and coronary artery stents.” 2010. Web. 01 Dec 2020.

Vancouver:

Graz F. Evaluation of diagnostic imaging quality of myocardium vascularisation with 64-slice ct considering coronary arteries, coronary arterial and venous bypass grafts and coronary artery stents. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-4414.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Graz F. Evaluation of diagnostic imaging quality of myocardium vascularisation with 64-slice ct considering coronary arteries, coronary arterial and venous bypass grafts and coronary artery stents. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-4414

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

25. Renger, Franziska. A POCT-Assay for the diagnosis of Rheumatoid Arthritis.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6524

► Rheumatoid arthritis (RA) is a worldwide inflammatory joint disease marked by an often chronic-progressive course leading to invalidity and working disability. Like in most autoimmune… (more)

▼ Rheumatoid arthritis (RA) is a worldwide inflammatory joint disease marked by an often chronic-progressive course leading to invalidity and working disability. Like in most autoimmune diseases, women are more affected than men. The diagnose rheumatoid arthritis is mainly clinical but detection of rheumatoid factor (RF) and antibodies to citrullinated peptides (ACPA) per ELISA help to confirm it. At early stages of disease, diagnosis may be difficult and time consuming as presentation occurs to be oligosymptomatic or asymmetric. However, early diagnosis and consecutive treatment with disease modifying anti-rheumatic drugs (DMARDs) within three to six months from symptom onset are crucial for a successful management of rheumatoid arthritis, as well as in order to avoid or limit complications of the natural course of disease. Recently, anti-MCV, antibodies to mutated citrullinated vimentin, have been described as a novel marker for RA, providing a diagnostic sensitivity and specificity of 82 % and 98 %, respectively. Furthermore, anti- MCV have been isolated from synovial fluid of RA patients. Its high diagnostic specificity for rheumatoid arthritis and probable implication in the pathogenesis of the disease make it an interesting and relevant antigen for rheumatoid arthritis. To further facilitate ACPA testing, a simple and quick point of care test (POCT) using a lateral flow immunochromatographic device has been developed for simultaneous detection of anti-MCV and IgG-RF. A blood drop was placed on the device and, after adding assay buffer, results were visible within 10 to 15 minutes by color formation. The device also provides an integrated control system indicating correct test performance. The aim of the study was to evaluate this newly developed POCT assay in a clinical setting. Two hundred thirty patients and 200 healthy blood donors were analyzed for anti-MCV and IgG-RF seropositivity using the POCT as well as commercially available ELISA. All patients were recruited from the outpatient clinics of the Department of Rheumatology and Clinical Immunology at the Charité-Universitätsmedizin Berlin and at Rheumaklinik Berlin-Buch. Within 230 patients, 108 had a seropositive/ACPA-positive course of RA and 122 had other rheumatic disorders. Main diagnoses in the control group were ankylosing spondylitis, psoriatic arthritis and seronegative course of rheumatoid arthritis. Using the POCT, diagnostic sensitivity for detection of anti-MCV antibodies was 54.6 % and specificity was 99.1 %, with only one false-positive result for anti-MCV. The positive predictive value of anti-MCV positivity regarding the diagnosis RA was 100 % and negative predictive value was 71.3 %. As to ELISA’s results, sensitivity and specificity were 69.3 % and 99.7 %, respectively. Overall agreement between POCT and ELISA regarding the detection of anti-MCV was 93 %. Very high specificity permits using this POCT-Assay as a confirmatory test for diagnosing RA. Results regarding RF-IgG were the following: diagnostic sensitivity was 55.6 % and… Advisors/Committee Members: [email protected] (contact), n (gender), Dr. sc. med. Dr. rer. nat. K. Egerer (firstReferee), Priv.-Doz. Dr. med. A. Lukowsky (furtherReferee), Prof. Dr. med. M. Schneider (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Renger, F. (2010). A POCT-Assay for the diagnosis of Rheumatoid Arthritis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6524

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Renger, Franziska. “A POCT-Assay for the diagnosis of Rheumatoid Arthritis.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-6524.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Renger, Franziska. “A POCT-Assay for the diagnosis of Rheumatoid Arthritis.” 2010. Web. 01 Dec 2020.

Vancouver:

Renger F. A POCT-Assay for the diagnosis of Rheumatoid Arthritis. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-6524.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Renger F. A POCT-Assay for the diagnosis of Rheumatoid Arthritis. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-6524

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

26. Schwartzmann, Anna. a systematic duplex ultrasound anallysis.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12103

► Objective: Investigation of the effect of the reduced heart output on the CBF. The CBF was assessed using the duplex ultrasound method by measuring the… (more)

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schwartzmann, A. (2010). a systematic duplex ultrasound anallysis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schwartzmann, Anna. “a systematic duplex ultrasound anallysis.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-12103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schwartzmann, Anna. “a systematic duplex ultrasound anallysis.” 2010. Web. 01 Dec 2020.

Vancouver:

Schwartzmann A. a systematic duplex ultrasound anallysis. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-12103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schwartzmann A. a systematic duplex ultrasound anallysis. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-12103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

27. Buckendahl, John Alexander. Clinical pathology and prevention of Tungiasis in a shantytown in Northeast Brazil.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14154

► Background: Tungiasis, an ectoparasitosis caused by the female sand flea Tunga penetrans, is an important health problem in many impoverished communities in the tropics 1,… (more)

▼ Background: Tungiasis, an ectoparasitosis caused by the female sand flea Tunga penetrans, is an important health problem in many impoverished communities in the tropics 1, 2, 3, 4, 5. In this study we investigated, whether the intermittent application of a plant based repellent (Zanzarin ®) keeps the infestation rate at an acceptable low level, and prevents severe clinical pathology to develop. Another aim was to compare the topographic distribution of embedded sand fleas in humans and Wistar rats. Methodology: 142 inhabitants of a shantytown in Fortaleza/Brazil, who had an elevated parasite load, were identified. The number of lesions, localization, staging and clinical pathology and the demographic and socioeconomic characteristics were recorded. We compared the topographic distribution of lesions in patients with the distribution of penetrated sandfleas in 80 laboratory raised Wistar rats. The rats were placed in cages for a period of 14 days and examined daily for the presence of new sand flea lesions. The patients were randomized into three cohorts. Initially, during a period of four weeks, the repellent was applied twice daily to the feet of all cohort members, to reduce the infestation intensity to 0. Thereafter members of cohort A applied the repellent every second week twice daily for one week, members of cohort B every fourth week for one week. Members of cohort C did not receive any treatment and served as controls. Infestation intensity and tungiasis-associated morbidity were monitored during five months. Results: 64,7% of households had constructed their homes from recycled material and 50.7% of the houses possessed no solid ground (wood, concrete, stone). 97% of households had connection to the electricity network, 83% of households were connected to the public water supply. The average monthly wage was 119 Real (interquartile range 60-200 Real), which corresponded to the time of study 52 € (interquartile range 25-81 €). The median age was eight years (minimum 1 - maximum 66). 48% of the participants were male and 52% female. In 93% of the participants we found edema of the feet, 70.9% of participants had fissures and pain when walking and 99.3% had nail deformities. A total of 3,445 T. penetrans lesions were found (median 17 lesions, minimum 5, maximum 98 lesions). After 14 days of exposure 59 of 80 animals (74%) were infested. Per animal penetrated median two sand fleas (interquartile range 1-6). The topographical distribution of the penetrated sand fleas was almost identical in Wistar rats and patients. The patients had 70.2% of the lesions on the toes, and the Wistar rats, 65.7% in the phalanges (p = 0.79). Toe and Digitus 1 and 5 were affected significantly more often than the other toes (p = 0.004 and p = 0.002). During the five-month interventional study the infestation intensity in cohort A was reduced to a median of 4 lesions (Interquartile Range 1 - 9). Compared to cohort A in cohort B the infestation intensity remained twice as high (median 8 lesions, Interquartile Range 9 - 16; p = 0.0035)… Advisors/Committee Members: [email protected] (contact), m (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: Tungiasis; prevention; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buckendahl, J. A. (2014). Clinical pathology and prevention of Tungiasis in a shantytown in Northeast Brazil. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14154

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Buckendahl, John Alexander. “Clinical pathology and prevention of Tungiasis in a shantytown in Northeast Brazil.” 2014. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-14154.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Buckendahl, John Alexander. “Clinical pathology and prevention of Tungiasis in a shantytown in Northeast Brazil.” 2014. Web. 01 Dec 2020.

Vancouver:

Buckendahl JA. Clinical pathology and prevention of Tungiasis in a shantytown in Northeast Brazil. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-14154.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Buckendahl JA. Clinical pathology and prevention of Tungiasis in a shantytown in Northeast Brazil. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-14154

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

28. Rubach, Katharina. The efficiency of the Telepathology Consultation Service in the context of the Breast Screening Programme.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12287

► Aims: With the decision of the Lower House of the German Parliament on July 28th in 2002 a German screening program was started for identifying… (more)

▼ Aims: With the decision of the Lower House of the German Parliament on July 28th in 2002 a German screening program was started for identifying breast cancer in the population of women fifty and above. The order was issued to the federal medical insurance alliance and the high associations of the health insurance company. For the first time German and European guidelines were established in this program to guarantee the high quality and the special standards: All given statements of the radiologists and pathologists have to be verified by a second opinion. But this advance in quality is combined with a delay in time and additional expenses. In order to reduce the costs and to speed up the second opinion process a new Telepathology Consultation Service was developed based on the experiences of the Telepathology Consultation Center (TPCC) of the Union International Contre le Cancer (UICC). To examine the diagnostic certainty and the effectiveness of telepathological consultation in comparison to conventional consultation a study was started in January 2005 which is the subject-matter of this assignment. Methods and Material: The complete web-based service is operated under MS Windows 2003 Server. As web server the Internet Information Server was used and as database the SQL-Server (both Microsoft products). The websites, forms and control mechanism have been encrypted by ASP scripts and JavaScript. A study containing 313 cases of mamma- routine-diagnostics has been carried out. All participant pathologists worked as first consultants, conventional second consultants and as second telepathological consultants. Results & Conclusion: The quality of telepathological diagnosis was equal to the conventional diagnosis. In fact Telepathology allows a faster respond of one to two days (conventional postal delay). The time to prepare a telepathology request is about twice as the conventional time. This ratio may be inverted by an interface between the Pathology Information System and the Telepathology Server and the use of virtual microscopy. Finally the Telepathology Consultation Service of the Professional Association of German Pathologists is a fast and effective German-language, internet-based service for obtaining a second opinion. The results of this study were first published in 2005 and the study has been awarded to be the “best research contribution 2005” at the 89th Congress of the Professional Association of German Pathologists (18th – 21st May 2005). Advisors/Committee Members: n (gender), Prof. Dr. med. M. Dietel (firstReferee), Prof. Dr. med. M. Pross (furtherReferee), Prof. Dr. Dr. Dr. h.c. mult. K. Kayser (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rubach, K. (2010). The efficiency of the Telepathology Consultation Service in the context of the Breast Screening Programme. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12287

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rubach, Katharina. “The efficiency of the Telepathology Consultation Service in the context of the Breast Screening Programme.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-12287.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rubach, Katharina. “The efficiency of the Telepathology Consultation Service in the context of the Breast Screening Programme.” 2010. Web. 01 Dec 2020.

Vancouver:

Rubach K. The efficiency of the Telepathology Consultation Service in the context of the Breast Screening Programme. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-12287.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rubach K. The efficiency of the Telepathology Consultation Service in the context of the Breast Screening Programme. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-12287

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

29. Fischer, Lars. impact of the meningeal comartiment on rtherapy and prognosis.

Degree: 2011, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-13051

► The prognosis of primary and secondary CNS lymphomas is inferior compared to systemic non-Hodgkin’s lymphomas. Many questions concerning their pathogenesis remain to be answered. In… (more)

Subjects/Keywords: PCNSL; meningeal; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Fischer, L. (2011). impact of the meningeal comartiment on rtherapy and prognosis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13051

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fischer, Lars. “impact of the meningeal comartiment on rtherapy and prognosis.” 2011. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-13051.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fischer, Lars. “impact of the meningeal comartiment on rtherapy and prognosis.” 2011. Web. 01 Dec 2020.

Vancouver:

Fischer L. impact of the meningeal comartiment on rtherapy and prognosis. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-13051.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fischer L. impact of the meningeal comartiment on rtherapy and prognosis. [Thesis]. Freie Universität Berlin; 2011. Available from: http://dx.doi.org/10.17169/refubium-13051

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

30. Pierskalla, Mirja. Retrospective Examination of Patients with Gastric Cancer for Clinical- Pathological Prognostic Factors and their Correlation with Chemokin CXCR4.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14085

► Gastric cancer is a widespread disease and a common tumor type. Despite of reduced incidence in Western countries in the last few years, globally gastric… (more)

▼ Gastric cancer is a widespread disease and a common tumor type. Despite of reduced incidence in Western countries in the last few years, globally gastric cancer plays an important role in tumor related causes of death. The prognosis of gastric cancer at time of diagnosis is commonly bad, due to a late identification of the tumor. This emphasizes the need for a search of prognosis determining factors, in order to improve outcomes and establish new ways of treatment. In light of this situation, we conducted a study in which 100 subjects were examined for relevant prognosis parameters and their correlation with survival time. We show that known factors like tumor state, lymph node infestation, metastation, lymphatics and cardiovascular angioinvasion and the extent of resection have a significant effect on survival time. This confirms prior results in the literature. In the last several years Chemokines and their receptors have gained attention for their role in tumor biology, specifically tumor growth and the occurence of metastases. This opens new ways of diagnostics, prognosis and treatment. In particular, for gastric cancer Chemokin CXCL 12 and its receptor CXCR4 were detected. Building on this result, we examined the reltaionship between CXCR4 expression and the prognostic parameters mentioned above. We did not find a significant relationship between CXCR4 and prognostic parameters, but to some degree we found a tendencies of covariation with clinical-pathological parameters. In general, the survival time in the CXCR4 positive group was reduced. Furthermore, CXCR4 positive patients had a progressed UICC tumor state and a stronger invasion of the lymphatics. These results confirm the role of Chemokines in general tumor biology and growth. Nonetheless, there exist contrary results from the literature. This points at a complex role of Chemokines for tumor biology. So far, no large clinical study on this topic has been conducted. Given the potential role of Chemokines and their receptors for tumor diagnosis, prognosis and treatment, more research needs to be done. Advisors/Committee Members: [email protected] (contact), n (gender), Priv.-Doz. Dr. med. G. Schumacher (firstReferee), Priv.-Doz. Dr. med. F. A. Wenger (furtherReferee), Priv.-Doz. Dr. med. J.-P. Ritz (furtherReferee).

Subjects/Keywords: 600 Technik; Medizin; angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Pierskalla, M. (2010). Retrospective Examination of Patients with Gastric Cancer for Clinical- Pathological Prognostic Factors and their Correlation with Chemokin CXCR4. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pierskalla, Mirja. “Retrospective Examination of Patients with Gastric Cancer for Clinical- Pathological Prognostic Factors and their Correlation with Chemokin CXCR4.” 2010. Thesis, Freie Universität Berlin. Accessed December 01, 2020. http://dx.doi.org/10.17169/refubium-14085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pierskalla, Mirja. “Retrospective Examination of Patients with Gastric Cancer for Clinical- Pathological Prognostic Factors and their Correlation with Chemokin CXCR4.” 2010. Web. 01 Dec 2020.

Vancouver:

Pierskalla M. Retrospective Examination of Patients with Gastric Cancer for Clinical- Pathological Prognostic Factors and their Correlation with Chemokin CXCR4. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2020 Dec 01]. Available from: http://dx.doi.org/10.17169/refubium-14085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pierskalla M. Retrospective Examination of Patients with Gastric Cancer for Clinical- Pathological Prognostic Factors and their Correlation with Chemokin CXCR4. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-14085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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