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1. Guadall Roldán, Anna. Mecanismes de regulació de la Lisil Oxidasa i la Fibulina-5 a nivell vascular: modulació per hipòxia.

Degree: Departament de Biologia Cel·lular, 2012, Universitat de Barcelona

Vascular remodeling is a critical process in the development of cardiovascular diseases such as atherosclerosis and abdominal aorta aneurysm (AAA). Lysyl oxidase (LOX) and Fibulin-5 (FBLN5) are two extracellular matrix proteins essential for the elastic fiber development and maintenance, and they both have an active role in physiological processes in which vascular remodeling is involved. By using different animal models, these proteins have been suggested to be involved with atherosclerosis and AAA. A critical aspect of the vascular remodeling in the atherosclerotic lesion is the apparition of hypoxic areas. Endothelial cells are primary sensors to the hypoxic stress, responding to it in a complex but subtly regulated way that affects multiple aspects of its biology. Nevertheless, it has not been established if the hypoxic stimulus can modulate LOX and FBLN5 expression, nor its possible physiological repercussions. Research made in our group shows the importance of LOX in the endothelial activity and vascular function. LOX can control the genetic expression as well as the activity of growth factors essential for the vascular homeostasis, suggesting that this enzyme may control cellular functions essential for the development of cardiovascular diseases. Based on these results, we have considered as working hypothesis that LOX and FBLN5 are key proteins in the vascular homeostasis, that they take part of the vascular response to hypoxia, and that they contribute to the development of vascular diseases like atherosclerosis and the AAA. Our results show that hypoxia transcriptionally induces LOX and FBLN5 in endothelial cells. While HIF-1 plays a secondary role in the regulation of LOX, being also involved in this modulation Smad proteins and oxidative stress, it is the main factor responsible for the FBLN5 induction. We also demonstrate that the modulation of FBLN5 in endothelial cells contributes to their adaptive response to hypoxia. Moreover, we have observed that overexpressing LOX in endothelial cells downregulates α2-macroglobulin expression. Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Rodríguez Sinovas, Ma. Cristina (director), Martínez González, José (director), Durfort i Coll, Mercè (tutor), true (authorsendemail).

Subjects/Keywords: Lisil oxidasa; Lysyl oxidase; Fibulina-5; Hipòxia; Hipoxia; Vasos sanguinis; Vasos sanguíneos; Blood vessels; Aneurismes; Aneurysms; Aneurismas; Ciències Experimentals i Matemàtiques; 576

…55 5. LA FIBULINA-5… …5.8. PATOLOGIES RELACIONADES AMB ALTERACIONS EN LA FIBULINA-5 ............68 5.8.1. FBLN5 i… …92 5. ANÀLISI D’ACTIVITAT TRANSCRIPCIONAL… …teoria trombogènica o de la incrustació [5], en la que suggeria que l’engruiximent de… …l’únic indicador del risc de ruptura (>5 cm), i l’única ter pia que s’hi aplica és la… 

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APA (6th Edition):

Guadall Roldán, A. (2012). Mecanismes de regulació de la Lisil Oxidasa i la Fibulina-5 a nivell vascular: modulació per hipòxia. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/83590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Guadall Roldán, Anna. “Mecanismes de regulació de la Lisil Oxidasa i la Fibulina-5 a nivell vascular: modulació per hipòxia.” 2012. Thesis, Universitat de Barcelona. Accessed April 13, 2021. http://hdl.handle.net/10803/83590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Guadall Roldán, Anna. “Mecanismes de regulació de la Lisil Oxidasa i la Fibulina-5 a nivell vascular: modulació per hipòxia.” 2012. Web. 13 Apr 2021.

Vancouver:

Guadall Roldán A. Mecanismes de regulació de la Lisil Oxidasa i la Fibulina-5 a nivell vascular: modulació per hipòxia. [Internet] [Thesis]. Universitat de Barcelona; 2012. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10803/83590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guadall Roldán A. Mecanismes de regulació de la Lisil Oxidasa i la Fibulina-5 a nivell vascular: modulació per hipòxia. [Thesis]. Universitat de Barcelona; 2012. Available from: http://hdl.handle.net/10803/83590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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