subject:(5)

1. Elmidaoui, Yassir. Les relations Nord-Sud : le cas du partenariat euro-méditerranéen : North-South relations : the case of the euro-Mediterranean partnership.

Degree: Docteur es, Droit public, 2012, Université d'Artois

URL: http://www.theses.fr/2012ARTO0302

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Lors du sommet extraordinaire qui s’est déroulé à Barcelone en novembre 1995, vingt-cinq pays de l’Union Européenne et douze pays méditerranéens ont décidé de lancer… (more)

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Lors du sommet extraordinaire qui s’est déroulé à Barcelone en novembre 1995, vingt-cinq pays de l’Union Européenne et douze pays méditerranéens ont décidé de lancer un partenariat global euro-méditerranéen, l’idée des partenaires étant d’arriver à tourner une page de rupture qui a marqué les relations entre les deux rives pendant plusieurs années. En effet, ce pont, érigé sur une mer où, de part et d’autre, on assiste à un nombre croissant de tensions et de conflits, a constitué l’unique enceinte de dialogue et d’échanges entre les États du bassin méditerranéen. Malgré la domination des Européens en matière de décisions, ce choix demeure inéluctable pour le bon voisinage dans la région.Toute fois, sans un réel engagement de la part des deux partenaires méditerranéens, notamment la forte implication de l’Union Européenne pour construire un véritable projet d’intégration régionale, le processus euro-méditerranéen risque de se trouver dans la corbeille de l’histoire humaine.

At the time of the extraordinary summit which proceeded in Barcelona in November 1995, twenty-five countries of the European Union and twelve Mediterranean countries decided to launch a euro-Mediterranean total partnership, the idea of the partners being to manage to turn a page of rupture which marked the relations between two banks during several years. Indeed, this bridge, set up on a sea where, on both sides, one attends a growing number of tensions and conflicts, constituted the single enclosure of dialogue and exchanges between the States of the Mediterranean basin. In spite of the domination of Europeans as regards decisions, this choice remains inescapable for the good neighborhood in the area. Any time, without a real engagement on behalf of the two Mediterranean partners, in particular the strong implication of the European Union to build a true project of regional integration, the euro-Mediterranean process is likely to be in the basket of the human history.

Advisors/Committee Members: Raulin, Arnaud de (thesis director).

Subjects/Keywords: Ligue arabe; Dialogue "5 + 5"

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Elmidaoui, Y. (2012). Les relations Nord-Sud : le cas du partenariat euro-méditerranéen : North-South relations : the case of the euro-Mediterranean partnership. (Doctoral Dissertation). Université d'Artois. Retrieved from http://www.theses.fr/2012ARTO0302

Chicago Manual of Style (16^th Edition):

Elmidaoui, Yassir. “Les relations Nord-Sud : le cas du partenariat euro-méditerranéen : North-South relations : the case of the euro-Mediterranean partnership.” 2012. Doctoral Dissertation, Université d'Artois. Accessed March 04, 2021. http://www.theses.fr/2012ARTO0302.

MLA Handbook (7^th Edition):

Elmidaoui, Yassir. “Les relations Nord-Sud : le cas du partenariat euro-méditerranéen : North-South relations : the case of the euro-Mediterranean partnership.” 2012. Web. 04 Mar 2021.

Vancouver:

Elmidaoui Y. Les relations Nord-Sud : le cas du partenariat euro-méditerranéen : North-South relations : the case of the euro-Mediterranean partnership. [Internet] [Doctoral dissertation]. Université d'Artois; 2012. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2012ARTO0302.

Council of Science Editors:

Elmidaoui Y. Les relations Nord-Sud : le cas du partenariat euro-méditerranéen : North-South relations : the case of the euro-Mediterranean partnership. [Doctoral Dissertation]. Université d'Artois; 2012. Available from: http://www.theses.fr/2012ARTO0302

2. Bevilacqua, Elisabetta. L'Algérie natale entre désenchantement et nostalgie : écritures plurielles de l'exil : Native Algeria between disenchantment and nostalgia : plural compositions of exile.

Degree: Docteur es, Langues, littératures et civilisations, 2015, Université de Lorraine; Università degli studi (Milan, Italie)

URL: http://www.theses.fr/2015LORR0060

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La question de la mémoire et de l’identité est au centre des débats contemporains. La guerre d’Algérie représente l’un des cas où cette question est… (more)

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La question de la mémoire et de l’identité est au centre des débats contemporains. La guerre d’Algérie représente l’un des cas où cette question est encore particulièrement brûlante, d’où la nécessité d’y revenir. La confrontation entre les mémoires plurielles des communautés impliquées par le conflit algérien a opposé une mémoire à l’autre, une identité à l’autre. Comment la littérature a-t-elle traduit ces conflits mémoriels et identitaires? À travers l’analyse de la production littéraire de trois écrivains d’origine algérienne exilés en France, ce travail étudie l’inscription du sujet identitaire et mémoriel à l’intérieur de la littérature algérienne francophone des années 70 et 80. Cette littérature, loin de constituer l’apanage exclusif des auteurs arabo-berbères, s’est enrichie grâce aux apports pluriels des auteurs pieds-noirs et juifs d’Algérie. Mettre en comparaison les ouvrages d’auteurs issus de milieux algériens différents permet de s’interroger sur la pluralité de cette littérature. Si le premier chapitre introduit théoriquement le sujet de l’identité, le deuxième illustre la manière dont les enjeux identitaires déterminent les questions mémorielles et historiques concernant l’Algérie contemporaine. Le troisième chapitre analyse la genèse et le développement de la littérature algérienne francophone, surtout de la littérature judéo-maghrébine et de la littérature pied-noir. Le dernier chapitre présente une analyse comparative des textes du corpus: Dieu en barbarie (1971) et Le maître de chasse (1973) de Mohammed Dib; Frimaldjézar (1976) et L’échelle de Mesrod (1984) d’Albert Bensoussan; Maman la Blanche (1981) et Alger l’amour (1982) d’Alain Vircondelet

The main aim of this research is to study the evolution of Algerian Francophone literature after independence proposing a new classification criterion which goes beyond the concept that North African literature in French language only consists of authors whose mother tongue is Arabic or Berber. The panorama of Algerian Francophone literature is indeed characterized by an extremely heterogeneous variety of productions: it is not only Arab and Berber authors who produce a remarkable literature, but Jewish and Pieds-Noirs writers as well. This study focuses on the plurality of the Algerian Francophone literature, highlighting the characteristics of every single cultural-specific production, i.e. the Arab-Berber, the Jewish and the Pied-Noir one, and asserting that each one has an overall consistency. The analysis is actually based on the hypothesis that every literary production presents specific thematic and stylistic levels, so that no one is reducible to another. The examined corpus consists of six novels written in French by writers born in Algeria during the colonization and exiled in France after 1962, each of them belonging to a specific cultural group: the Jewish writer Albert Bensoussan (Frimaldjézar, 1976, and L’échelle de Mesrod, 1984), the Pied-Noir novelist Alain Vircondelet (Maman la blanche, 1981, and Alger l’amour, 1982) and the Arab writer…

Advisors/Committee Members: Halen, Pierre (thesis director), Riva, Silvia (thesis director).

Subjects/Keywords: .; 840.996 5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bevilacqua, E. (2015). L'Algérie natale entre désenchantement et nostalgie : écritures plurielles de l'exil : Native Algeria between disenchantment and nostalgia : plural compositions of exile. (Doctoral Dissertation). Université de Lorraine; Università degli studi (Milan, Italie). Retrieved from http://www.theses.fr/2015LORR0060

Chicago Manual of Style (16^th Edition):

Bevilacqua, Elisabetta. “L'Algérie natale entre désenchantement et nostalgie : écritures plurielles de l'exil : Native Algeria between disenchantment and nostalgia : plural compositions of exile.” 2015. Doctoral Dissertation, Université de Lorraine; Università degli studi (Milan, Italie). Accessed March 04, 2021. http://www.theses.fr/2015LORR0060.

MLA Handbook (7^th Edition):

Bevilacqua, Elisabetta. “L'Algérie natale entre désenchantement et nostalgie : écritures plurielles de l'exil : Native Algeria between disenchantment and nostalgia : plural compositions of exile.” 2015. Web. 04 Mar 2021.

Vancouver:

Bevilacqua E. L'Algérie natale entre désenchantement et nostalgie : écritures plurielles de l'exil : Native Algeria between disenchantment and nostalgia : plural compositions of exile. [Internet] [Doctoral dissertation]. Université de Lorraine; Università degli studi (Milan, Italie); 2015. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2015LORR0060.

Council of Science Editors:

Bevilacqua E. L'Algérie natale entre désenchantement et nostalgie : écritures plurielles de l'exil : Native Algeria between disenchantment and nostalgia : plural compositions of exile. [Doctoral Dissertation]. Université de Lorraine; Università degli studi (Milan, Italie); 2015. Available from: http://www.theses.fr/2015LORR0060

University of Minnesota

3. Schissel, Ann. The Serotonin Transporter Polymorphism (5-HTTLPR) and potential interactions with adverse life events leading to Major Depressive Disorder: An approach addressing inconsistencies in the literature.

Degree: PhD, Psychology, 2015, University of Minnesota

URL: http://hdl.handle.net/11299/174889

► Serotonin (5-HT) has a demonstrated influence on several aspects of the human experience including personality, behavior, and psychopathology. One aspect of the 5- HT system… (more)

Subjects/Keywords: 5-HTTLPR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schissel, A. (2015). The Serotonin Transporter Polymorphism (5-HTTLPR) and potential interactions with adverse life events leading to Major Depressive Disorder: An approach addressing inconsistencies in the literature. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/174889

Chicago Manual of Style (16^th Edition):

Schissel, Ann. “The Serotonin Transporter Polymorphism (5-HTTLPR) and potential interactions with adverse life events leading to Major Depressive Disorder: An approach addressing inconsistencies in the literature.” 2015. Doctoral Dissertation, University of Minnesota. Accessed March 04, 2021. http://hdl.handle.net/11299/174889.

MLA Handbook (7^th Edition):

Schissel, Ann. “The Serotonin Transporter Polymorphism (5-HTTLPR) and potential interactions with adverse life events leading to Major Depressive Disorder: An approach addressing inconsistencies in the literature.” 2015. Web. 04 Mar 2021.

Vancouver:

Schissel A. The Serotonin Transporter Polymorphism (5-HTTLPR) and potential interactions with adverse life events leading to Major Depressive Disorder: An approach addressing inconsistencies in the literature. [Internet] [Doctoral dissertation]. University of Minnesota; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11299/174889.

Council of Science Editors:

Schissel A. The Serotonin Transporter Polymorphism (5-HTTLPR) and potential interactions with adverse life events leading to Major Depressive Disorder: An approach addressing inconsistencies in the literature. [Doctoral Dissertation]. University of Minnesota; 2015. Available from: http://hdl.handle.net/11299/174889

Tampereen ammattikorkeakoulu

4. Kivisilta, Juuso. Avant-pienkuormaajan nostopuomin hitsauksen menetelmäsuunnittelu.

Degree: 2017, Tampereen ammattikorkeakoulu

URL: http://www.theseus.fi/handle/10024/131159

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Tämän opinnäytetyön tavoitteena on kartoittaa R3-robottisolun toiminta-astetta ja ongelmakohtia. Menetelmäsuunnittelun, lean-filosofian ja 5S-standardoimistyökalun avulla saadaan solut organisoitua toimivimmiksi. Ongelmakartoitusta ja arvovirtakuvausta hyödyntäen saadaan selville tuottamattomat… (more)

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Tämän opinnäytetyön tavoitteena on kartoittaa R3-robottisolun toiminta-astetta ja ongelmakohtia. Menetelmäsuunnittelun, lean-filosofian ja 5S-standardoimistyökalun avulla saadaan solut organisoitua toimivimmiksi. Ongelmakartoitusta ja arvovirtakuvausta hyödyntäen saadaan selville tuottamattomat toiminnot, joihin solun kehitystyö keskittyy. Työn on tilannut Avant Tecno Oy. Opinnäytetyössä tutustutaan Mig-, Mag- ja robottihitsaukseen teoreettisesti kirjallisten lähteiden avulla sekä käytännönläheisesti. Tämän opinnäytetyön laatija vastaa itse käytännön tutkimuksesta ja käyttää myös omaa tietopohjaansa metallialan töistä, hyödyntäen työkokemustaan ja aiempia tutkintojaan. Useista eri lähteistä ja yrityksen työntekijöiltä saadut faktat auttavat työn aikana havaittujen lisäarvoa tuottamattomien osien kehitystyössä. Työn kautta selvennetään tehtaalla olevaa imuohjautuvaa tuotantostrategiaa ja selvitetään prosessin puutteet ja kehitystä vaativat alueet. Opinnäytetyössä tutkitaan ja analysoidaan prosessin alkutilanne, kehitystoimenpiteet, päivitykset ja saavutetut tulokset. Jatkuva parantaminen ja prosessien kehittäminen eivät saavuta koskaan loppuaan. Tämä työ antaa perustietopaketin hitsaamisesta ja robotisoinnista sekä avaimia kehittymiseen nyt ja tulevaisuudessa. Tutkimuksessa solun prosessien kehittämisessä esiin tulleita tuloksia ja dokumentteja voidaan hyödyntää myös tulevissa projekteissa ja mahdollisissa ongelmatilanteissa.

The purpose of this thesis was to identify the R3 robot cell operating rate and problem areas. Lean manufacturing and 5S- standard tool were used to get cells organized in a more functional manner. In this thesis is used couple tools like identifying problems method and value stream mapping, to get known the non-productive functions. The thesis was commissioned Avant Tecno Oy. The theoretical part introduces the Mig-, Mag- and robotic welding using literary sources. Whilst the practical part relied mainly on the practical study and knowledge of the author in metal works, making use of professional experience and previous examinations. The author of this thesis is responsible for the practical study and use his own knowledge base metal works, making use of professional experience and previous examinations. A variety of sources and facts from the company's employees helped to improve unproductive parts during this thesis. Work through the clarification of the factory production pull controlled strategy and explains the weaknesses, deficiencies and areas requiring development. The thesis studied and analyzed the process of the initial situation, measures of the development, equipment updatings and the all achieved results. It is important to continue to improve and develop processes. This work provides basic information about welding and using robot in automation, as well as the keys to development now and in the future. Results and documents which have emerged in the study can be utilised also in the future projects and in the possible problem situations.

Advisors/Committee Members: Tampereen ammattikorkeakoulu.

Subjects/Keywords: 5-S

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kivisilta, J. (2017). Avant-pienkuormaajan nostopuomin hitsauksen menetelmäsuunnittelu. (Thesis). Tampereen ammattikorkeakoulu. Retrieved from http://www.theseus.fi/handle/10024/131159

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kivisilta, Juuso. “Avant-pienkuormaajan nostopuomin hitsauksen menetelmäsuunnittelu.” 2017. Thesis, Tampereen ammattikorkeakoulu. Accessed March 04, 2021. http://www.theseus.fi/handle/10024/131159.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kivisilta, Juuso. “Avant-pienkuormaajan nostopuomin hitsauksen menetelmäsuunnittelu.” 2017. Web. 04 Mar 2021.

Vancouver:

Kivisilta J. Avant-pienkuormaajan nostopuomin hitsauksen menetelmäsuunnittelu. [Internet] [Thesis]. Tampereen ammattikorkeakoulu; 2017. [cited 2021 Mar 04]. Available from: http://www.theseus.fi/handle/10024/131159.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kivisilta J. Avant-pienkuormaajan nostopuomin hitsauksen menetelmäsuunnittelu. [Thesis]. Tampereen ammattikorkeakoulu; 2017. Available from: http://www.theseus.fi/handle/10024/131159

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Henry, Nina. Médecine régénératrice du disque intervertébral : développement de biomatériaux pour la libération prolongée de facteurs de croissance : Intervertebral disc regenerative medicine : Biomaterials design for growth factors sustained delivery.

Degree: Docteur es, Biomolécules, Pharmacologie, Thérapeutique, 2017, Nantes

URL: http://www.theses.fr/2017NANT1008

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La lombalgie liée à la dégénérescence du disque intervertébral (DIV) est un problème majeur de santé publique touchant une large proportion de nos populations vieillissantes.… (more)

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La lombalgie liée à la dégénérescence du disque intervertébral (DIV) est un problème majeur de santé publique touchant une large proportion de nos populations vieillissantes. Actuellement, la prise en charge de cette maladie est essentiellement symptomatique mais grâce à de récentes découvertes, les processus de dégénérescence discale sont aujourd'hui mieux compris. Ces nouvelles connaissances permettent d'envisager de nouvelles stratégies thérapeutiques. Parmi ces stratégies et afin de répondre aux stades précoces de cette maladie, une attention particulière est portée sur les stratégies impliquant l’injection intradiscale de facteurs de croissance tels que le GDF-5 ou le TGF-β1, ciblant les processus de dégénérescence du DIV. En dépit de résultats encourageants concernant la sécurité d’utilisation et la tolérance clinique de ces facteurs de croissance, leur efficacité clinique doit encore être amélioré. Pour cela, l’utilisation de biomateriaux permettant une libération prolongée et la protection des facteurs de croissance, présente un intérêt majeur. Ce travail de thèse a donc pour objectif le développement de systèmes à libération prolongée de ces deux facteurs de croissance. Pour ce faire, deux biomatériaux ont été étudiés : les nanofibres de silice et les microbilles de pullulane. Pour ces deux matériaux, leurs synthèses et caractérisations ont été réalisées avant de s'intéresser à leur potentiel d'adsorption et de libération des facteurs de croissance. Les résultats obtenus sont tres encourageants puisqu’ils montrent une libération prolongée jusqu’a 28 jours in vitro avec un maintien de l’activité biologique des facteurs de croissance libérés. L’ensemble des données de cette thèse suggère le potentiel prometteur des systèmes présentés pour le développement de stratégies innovantes pour la médecine régénératrice DIV.

Low back pain caused by the intervertebral disc (IVD) degeneration is a major health concern affecting a large proportion of our aging populations. While current treatments of this disease are mainly symptomatic, recent discoveries have allowed a better understanding of the degenerative processes and new therapeutic strategies have been envisioned. Among these strategies, there is a growing interest for approaches aiming a tackling early stages of this disease, involving the intradiscal injection of growth factors such as GDF-5 or TGF-β1, able to target IVD degenerative processes. However, despite encouraging results regarding the safety and clinical tolerance of these growth factors, their clinical efficacy has to be further improved. To this end, the use of biomaterials allowing the sustained release and the protection of growth factors is of particular interest. The objective of this thesis is thus to develop systems able to deliver these two growth factors in a long period of time. Therefore, two biomaterials were studied: silica nanofibers and pullulan microbeads. For both materials, their syntheses and characterizations were studied, as well as their potential use for growth factors…

Advisors/Committee Members: Guicheux, Jérôme (thesis director), Le Bideau, Jean (thesis director), Clouet, Johann (thesis director).

Subjects/Keywords: GDF-5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Henry, N. (2017). Médecine régénératrice du disque intervertébral : développement de biomatériaux pour la libération prolongée de facteurs de croissance : Intervertebral disc regenerative medicine : Biomaterials design for growth factors sustained delivery. (Doctoral Dissertation). Nantes. Retrieved from http://www.theses.fr/2017NANT1008

Chicago Manual of Style (16^th Edition):

Henry, Nina. “Médecine régénératrice du disque intervertébral : développement de biomatériaux pour la libération prolongée de facteurs de croissance : Intervertebral disc regenerative medicine : Biomaterials design for growth factors sustained delivery.” 2017. Doctoral Dissertation, Nantes. Accessed March 04, 2021. http://www.theses.fr/2017NANT1008.

MLA Handbook (7^th Edition):

Henry, Nina. “Médecine régénératrice du disque intervertébral : développement de biomatériaux pour la libération prolongée de facteurs de croissance : Intervertebral disc regenerative medicine : Biomaterials design for growth factors sustained delivery.” 2017. Web. 04 Mar 2021.

Vancouver:

Henry N. Médecine régénératrice du disque intervertébral : développement de biomatériaux pour la libération prolongée de facteurs de croissance : Intervertebral disc regenerative medicine : Biomaterials design for growth factors sustained delivery. [Internet] [Doctoral dissertation]. Nantes; 2017. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2017NANT1008.

Council of Science Editors:

Henry N. Médecine régénératrice du disque intervertébral : développement de biomatériaux pour la libération prolongée de facteurs de croissance : Intervertebral disc regenerative medicine : Biomaterials design for growth factors sustained delivery. [Doctoral Dissertation]. Nantes; 2017. Available from: http://www.theses.fr/2017NANT1008

University of Ottawa

6. Zhou, Yi Yuan. Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits .

Degree: 2011, University of Ottawa

URL: http://hdl.handle.net/10393/19761

► The 5-hydroxytryptamine (5-HT) system modulates numerous physiological and behavioural processes, and dysfunction within this system underlies many behavioural disorders, such as major depression. The 5-HT1A… (more)

Subjects/Keywords: 5-HT1A; BRET; 5-HT1A signaling

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APA (6^th Edition):

Zhou, Y. Y. (2011). Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/19761

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhou, Yi Yuan. “Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits .” 2011. Thesis, University of Ottawa. Accessed March 04, 2021. http://hdl.handle.net/10393/19761.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhou, Yi Yuan. “Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits .” 2011. Web. 04 Mar 2021.

Vancouver:

Zhou YY. Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits . [Internet] [Thesis]. University of Ottawa; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10393/19761.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhou YY. Structural Determinants of 5-Ht1a Receptor Interaction With Gαi Subunits . [Thesis]. University of Ottawa; 2011. Available from: http://hdl.handle.net/10393/19761

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pennsylvania

7. Denizio, Jamie Elizabeth. Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine.

Degree: 2019, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/3301

► The Ten-eleven-translocation (TET) family of enzymes can oxidize the fifth base of DNA, 5-methylcytosine (mC) sequentially, to 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), and 5-carboxycytosine (caC). The… (more)

▼ The Ten-eleven-translocation (TET) family of enzymes can oxidize the fifth base of DNA, 5-methylcytosine (mC) sequentially, to 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), and 5-carboxycytosine (caC). The biochemical preference of TET enzymes for these substrates, in the canonical cytosine guanine dinucleotides (CpG), mimics the order in which they are generated and is reflected in levels of these oxidized modifications (oxmCs) detected in various genomes. Other than this exception, there is conflicting or limited data concerning intrinsic substrate preferences of TET, particularly with regards to different nucleic acid structures, sequence contexts, and extent to which TET mediates oxmCs in clustered proximity to one another. Thus, in this thesis, I present our efforts to determine intrinsic substrate preferences of TET enzymes, and in doing so expand upon our understanding of mechanisms driving these relative activities and the functional significance of observed levels of oxmCs in vivo. After a review of the field, in Chapter 2, I present our work comparing TET activity on different DNA and RNA structures in vitro. We found that TET is relatively promiscuous on a variety of DNA/RNA structures but prefers DNA, a specificity that is dictated by nucleic acid identity of the target base, as well helical conformation of the substrate. In Chapter 3, I newly expose the relative tolerance of TET activity on hmC with a non-G at the +1 base, although mCpG is still largely preferred. This tolerance for hmC oxidation by TET and fC and caC excision by TDG, regardless of the +1 base, supports a model explaining hmCpH depletion relative to mCpH and hmCpG in some genomes. In Chapter 4, I narrate our efforts to quantify clusters of oxmCs using modification-specific sequencing methods and observe that TET is intrinsically capable of clusters of at least fC and caC. Also, we explore the possibility that these clusters are mediated by either strand processivity of TET or underlying sequence context preferences. Finally, I propose two kinetics-based experiments to test our hypotheses regarding mechanisms driving these substrate preferences, along with ways to exploit our knowledge of TET enzymes for creation of more efficient and specific epigenetic editing tools.

Subjects/Keywords: 5-hydroxymethylcytosine; 5-methylcytosine; enzymology; epigenetics; Biochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Denizio, J. E. (2019). Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/3301

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Denizio, Jamie Elizabeth. “Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine.” 2019. Thesis, University of Pennsylvania. Accessed March 04, 2021. https://repository.upenn.edu/edissertations/3301.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Denizio, Jamie Elizabeth. “Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine.” 2019. Web. 04 Mar 2021.

Vancouver:

Denizio JE. Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine. [Internet] [Thesis]. University of Pennsylvania; 2019. [cited 2021 Mar 04]. Available from: https://repository.upenn.edu/edissertations/3301.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Denizio JE. Nucleobase, Nucleoside, And Neighboring Nucleotides: Intrinsic Preferences For Tet Enzyme-Mediated Oxidation Of 5-Methylcytosine. [Thesis]. University of Pennsylvania; 2019. Available from: https://repository.upenn.edu/edissertations/3301

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Dubuissez, Marion. Modifications post-traductionnelles de HIC1 et de BCL11 modulant le recrutement du complexe NuRD et mise en évidence de trois nouveaux gènes cibles directs de HIC1 : Post-translational modifications of HIC1 and BCL11B regulating the NuRD recruitment and identification of three new target genes of HIC1.

Degree: Docteur es, Biochimie et biologie moléculaire, 2015, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2015LIL10080

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La famille des protéines MTA (Metastasis Tumor Antigen) compte trois membres MTA1, 2 et 3 qui diffèrent au niveau de leur extrémité C-terminale, une région… (more)

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La famille des protéines MTA (Metastasis Tumor Antigen) compte trois membres MTA1, 2 et 3 qui diffèrent au niveau de leur extrémité C-terminale, une région désorganisée. La région N-terminale est impliquée dans l’interaction avec le complexe corépresseur NuRD. NuRD est recruté par des facteurs de transcription au niveau de leurs gènes cibles pour réprimer la transcription. Les protéines HIC1 et BCL11 recrutent le complexe NuRD via les protéines MTA afin de réprimer leurs gènes cibles.Au cours de ma thèse, je me suis intéressée aux modalités d’interactions entre les protéines HIC1 et BCL11 interagissant toutes deux avec l’extrémité C-terminale des protéines MTA. Dans ce cadre, nous avons montré que l’interaction HIC1-BCL11 ne semble pas jouer un rôle direct dans la régulation synergique de gènes cibles communs. Ensuite, nous avons montré que les protéines BCL11 interagissent avec les trois protéines MTA via leur motif N-terminal conservé MSRRKQ pour recruter différents complexes NuRD. De plus, la phosphorylation de la Sérine 2 de BCL11B médiée par PKC (Protein Kinase C) lors de l’activation des lymphocytes T CD4+, régule son activité de facteur de transcription. De plus, nous avons identifié CXCL12/SDF1 comme nouveau gène cible de HIC1 dans les lymphocytes T CD4+. Cette chimiokine est le ligand commun aux récepteurs CXCR4 et CXCR7 impliqués dans la migration et le « homing » des cellules de l’immunité. Enfin, nous avons également identifié deux nouveaux gènes cibles de HIC1 : ApoER2 et VLDLR codant tous deux des récepteurs à la Reelin. Cette voie de signalisation est impliquée dans la migration des précurseurs neuronaux lors du développement du cervelet.

MTA (Metastasis Tumor Antigen) proteins family is composed of three members: MTA1, 2 and 3 which differ in their C-terminus, a disorganized domain. The N-terminal region is involved in the interaction with the NuRD corepressor complex. NuRD is recruited by transcription factors at their target genes to repress transcription. HIC1 and BCL11 proteins recruit NuRD through interaction with MTA proteins to repress their target genes. In the first part of my work, we have deciphered the mechanisms of interactions between HIC1 and BCL11 proteins which both also interacted with MTA proteins. In this context, we showed that HIC1-BCL11 interaction does not allow the direct synergistic repression of common target genes. In the second part of my work, we showed that BCL11 proteins interact with the three MTA members via their conserved MSRRKQ motif to recruit NuRD complexes. Furthermore, we identified the PKC (Protein Kinase C)-mediated phosphorylation of BCL11B Serine 2 which regulates its transcription factor’s activity during activation of human CD4+ T lymphocytes. In fact, the phosphorylation of BCL11B Serine 2 allows the switch from a transcriptional repressor to an activator during TCR activation of human CD4+ T cells. In parallel to this work, we identified SDF1 as a new direct target gene of HIC1 in these cells. The SDF1 chemokine is the common ligand for chemokine…

Advisors/Committee Members: Leprince, Dominique (thesis director).

Subjects/Keywords: Hic1; 572.884 5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dubuissez, M. (2015). Modifications post-traductionnelles de HIC1 et de BCL11 modulant le recrutement du complexe NuRD et mise en évidence de trois nouveaux gènes cibles directs de HIC1 : Post-translational modifications of HIC1 and BCL11B regulating the NuRD recruitment and identification of three new target genes of HIC1. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2015LIL10080

Chicago Manual of Style (16^th Edition):

Dubuissez, Marion. “Modifications post-traductionnelles de HIC1 et de BCL11 modulant le recrutement du complexe NuRD et mise en évidence de trois nouveaux gènes cibles directs de HIC1 : Post-translational modifications of HIC1 and BCL11B regulating the NuRD recruitment and identification of three new target genes of HIC1.” 2015. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2015LIL10080.

MLA Handbook (7^th Edition):

Dubuissez, Marion. “Modifications post-traductionnelles de HIC1 et de BCL11 modulant le recrutement du complexe NuRD et mise en évidence de trois nouveaux gènes cibles directs de HIC1 : Post-translational modifications of HIC1 and BCL11B regulating the NuRD recruitment and identification of three new target genes of HIC1.” 2015. Web. 04 Mar 2021.

Vancouver:

Dubuissez M. Modifications post-traductionnelles de HIC1 et de BCL11 modulant le recrutement du complexe NuRD et mise en évidence de trois nouveaux gènes cibles directs de HIC1 : Post-translational modifications of HIC1 and BCL11B regulating the NuRD recruitment and identification of three new target genes of HIC1. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2015. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2015LIL10080.

Council of Science Editors:

Dubuissez M. Modifications post-traductionnelles de HIC1 et de BCL11 modulant le recrutement du complexe NuRD et mise en évidence de trois nouveaux gènes cibles directs de HIC1 : Post-translational modifications of HIC1 and BCL11B regulating the NuRD recruitment and identification of three new target genes of HIC1. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2015. Available from: http://www.theses.fr/2015LIL10080

9. Ramy-Ratiarison, Rindra. Compoundage et transformation par injection de PLA renforcé par des fibres de cellulose : Analyse de la cristallisation, formulation et propriétés thermomécaniques induites : Compounding and injection molding of PLA reinforced by cellulose fibers : crystallization, formulation and induced thermomechanical properties analysis.

Degree: Docteur es, Molécules et Matière Condensée, 2010, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2010LIL10176

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L’objectif de ce travail était d’étudier le compoundage et la transformation par injection de composites PLA renforcés par des fibres de cellulose. La première partie… (more)

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L’objectif de ce travail était d’étudier le compoundage et la transformation par injection de composites PLA renforcés par des fibres de cellulose. La première partie concerne l’influence des conditions de compoundage et d’injection sur la structure du PLA. En particulier, l’influence des paramètres de mise en œuvre sur la dégradation durant l’extrusion a été mise en évidence. D’autre part, l’étude de la cristallisation met en évidence un phénomène singulier de dilatation du PLA durant la cristallisation froide dans le cas de pièces injectées. L’optimisation de l’étape de compoundage des composites est présentée dans la seconde partie. L’objectif était d’éviter la dégradation durant l’extrusion et d’optimiser la dispersion des fibres de cellulose. Un plan d’expérience a été utilisé pour définir les optimums des paramètres d’extrusion afin de limiter la dégradation et d’améliorer la dispersion des fibres de cellulose. Les compounds optimisés ont été utilisés pour étudier l’influence des paramètres d’injection sur la structure des composites et leur impact sur les propriétés mécaniques des composites injectés. Enfin, l’optimisation des propriétés thermomécaniques au travers de l’étude de la formulation des composites est présentée. Plus particulièrement, l’effet de la plastification du PLA et la compatibilisation à l’interface utilisant un PLA greffé anhydride maléique sont rapportés.

The aim of this work was to study the compounding and injection molding of PLA composites based on cellulose fibres. In the first part, the influence of compounding and injection molding on the structure of the PLA is presented. Particularly, the influence of processing conditions on the degradation during extrusion was investigated. The study of the cristallization behavior evidenced an usual dilatation of PLA during cold cristallization in the case of injection molded parts. The optimization of the compounding step of the composites is presented in a second part. The aim was to avoid the degradation during the extrusion process and to optimize the dispersion of the cellulose fibers. A design of experiment was used to define the optimum compounding parameters in order to limit the degradation and improve the dispersion of the cellulose fibers. The optimized compounds were used to study the influence of injection molding conditions on the structure of the composites and its influence on the mechanical properties of injection molded composites. Finally, the optimization of composites thermomechanical properties using formulation was proposed. Particularly, the effect of plasticizing of PLA and the compatibilization at the interface using maleic anhydride grafted PLA are presented.

Advisors/Committee Members: Krawczak, Patricia (thesis director), Lacrampe, Marie-France (thesis director).

Subjects/Keywords: Compoundage; 668.422 5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ramy-Ratiarison, R. (2010). Compoundage et transformation par injection de PLA renforcé par des fibres de cellulose : Analyse de la cristallisation, formulation et propriétés thermomécaniques induites : Compounding and injection molding of PLA reinforced by cellulose fibers : crystallization, formulation and induced thermomechanical properties analysis. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2010LIL10176

Chicago Manual of Style (16^th Edition):

Ramy-Ratiarison, Rindra. “Compoundage et transformation par injection de PLA renforcé par des fibres de cellulose : Analyse de la cristallisation, formulation et propriétés thermomécaniques induites : Compounding and injection molding of PLA reinforced by cellulose fibers : crystallization, formulation and induced thermomechanical properties analysis.” 2010. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2010LIL10176.

MLA Handbook (7^th Edition):

Ramy-Ratiarison, Rindra. “Compoundage et transformation par injection de PLA renforcé par des fibres de cellulose : Analyse de la cristallisation, formulation et propriétés thermomécaniques induites : Compounding and injection molding of PLA reinforced by cellulose fibers : crystallization, formulation and induced thermomechanical properties analysis.” 2010. Web. 04 Mar 2021.

Vancouver:

Ramy-Ratiarison R. Compoundage et transformation par injection de PLA renforcé par des fibres de cellulose : Analyse de la cristallisation, formulation et propriétés thermomécaniques induites : Compounding and injection molding of PLA reinforced by cellulose fibers : crystallization, formulation and induced thermomechanical properties analysis. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2010. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2010LIL10176.

Council of Science Editors:

Ramy-Ratiarison R. Compoundage et transformation par injection de PLA renforcé par des fibres de cellulose : Analyse de la cristallisation, formulation et propriétés thermomécaniques induites : Compounding and injection molding of PLA reinforced by cellulose fibers : crystallization, formulation and induced thermomechanical properties analysis. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2010. Available from: http://www.theses.fr/2010LIL10176

10. Chomat, Dimitri. Élaboration et mise en forme de composites micro-fibrillaires par fibrillation in-situ : optimisation de la microstructure et des propriétés mécaniques résultantes : Elaboration and processing of micro-fibrillar composites by means of in-situ fibrillation : optimization of microstructure and mechanical properties.

Degree: Docteur es, Molécules et matière condensée, 2013, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2013LIL10127

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L'élaboration de composites micro-fibrillaires a été réalisée par fibrillation in-situ à partir de couples de polymères immiscibles. Dans un premier temps, un mélange polypropylène /… (more)

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L'élaboration de composites micro-fibrillaires a été réalisée par fibrillation in-situ à partir de couples de polymères immiscibles. Dans un premier temps, un mélange polypropylène / polyamide 6 (PP/PA6) a été utilisé comme référence pour la mise au point du procédé d'extrusion - étirage en continu. En faisant varier les paramètres rhéologiques, il est apparu que la fibrillation est soumise aux conditions d'un rapport de viscosité inférieur à 4 et d'un rapport d'élasticité inférieur à 1 durant le mélangeage. Des expériences portant sur la température de mise en forme des composites micro-fibrillaires par injection ont montré que la préservation de la morphologie nécessite une température inférieure à la température de fusion de la phase dispersée. Dans un deuxième temps, ces travaux ont porté sur l'incorporation de nanocharges d'argile dans un but de compatibilisation du mélange PP/PA6. Différentes voies d'ajout de la montmorillonite modifiée ont été testées. Parmi celles-ci, il a été vu que la pré-dispersion de la nanocharge dans la matrice PP aboutit à une migration des feuillets d'argile du PP vers l'interface PP/PA6 lors du procedé de fibrillation in-situ. Un affinement des fibrilles a été constaté à cette occasion, entraînant une amélioration de la résistance au choc. Enfin, une dernière partie a été consacrée au développement d'un composite micro-fibrillaire bio-sourcé acide polylactique / polyamide 11 sur la base des résultats précédemment acquis. Bien qu'une morphologie partiellement fibrillaire ait été formée lors de l'étirage, la mise en forme du composite par injection a entraîné la destruction des fibrilles par échauffement et relaxation.

Elaboration of microfibrillar composites based on immiscible polymer blends was performed by means of in-situ fibrillation. First, a polypropylene / polyamide 6 blend (PP/PA6) was used as a reference in order to develop an extrusion - drawing process. Upon variation of rheological parameters, it appeared that fibrillation requests a viscosity ratio less than 4 and an elastic ratio less than 1. Experiences about influence of processing temperature demonstrated that the injection step must be proceed at a temperature lower than the melting temperature of the dispersed phase in order to preserve the morphology. In a second part, this study dealt with the incorporation of organically modified montmorillonite with the aim of compatibilizing PP/PA6 blends. Several ways of nanoclay addition have been tested. Among them, nanoclay pre-dispersion in the PP matrix lead to the migration of clay platelets from PP to PP/PA6 interface during the in-situ fibrillation process. Hence, fibrils refinement was observed, inducing an improvement of impact resistance. Finally, one last part was dedicated to the development of a poly(lactic acid) / polyamide 11 bio-based micro-fibrillar composite. Whereas a partially fibrillar morphology was formed upon drawing, injection of the composite involved fibrils destruction due to overheating and subsequent relaxation.

Advisors/Committee Members: Lacrampe, Marie-France (thesis director), Soulestin, Jérémie (thesis director).

Subjects/Keywords: Montmorillonite; 668.422 5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chomat, D. (2013). Élaboration et mise en forme de composites micro-fibrillaires par fibrillation in-situ : optimisation de la microstructure et des propriétés mécaniques résultantes : Elaboration and processing of micro-fibrillar composites by means of in-situ fibrillation : optimization of microstructure and mechanical properties. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2013LIL10127

Chicago Manual of Style (16^th Edition):

Chomat, Dimitri. “Élaboration et mise en forme de composites micro-fibrillaires par fibrillation in-situ : optimisation de la microstructure et des propriétés mécaniques résultantes : Elaboration and processing of micro-fibrillar composites by means of in-situ fibrillation : optimization of microstructure and mechanical properties.” 2013. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2013LIL10127.

MLA Handbook (7^th Edition):

Chomat, Dimitri. “Élaboration et mise en forme de composites micro-fibrillaires par fibrillation in-situ : optimisation de la microstructure et des propriétés mécaniques résultantes : Elaboration and processing of micro-fibrillar composites by means of in-situ fibrillation : optimization of microstructure and mechanical properties.” 2013. Web. 04 Mar 2021.

Vancouver:

Chomat D. Élaboration et mise en forme de composites micro-fibrillaires par fibrillation in-situ : optimisation de la microstructure et des propriétés mécaniques résultantes : Elaboration and processing of micro-fibrillar composites by means of in-situ fibrillation : optimization of microstructure and mechanical properties. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2013. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2013LIL10127.

Council of Science Editors:

Chomat D. Élaboration et mise en forme de composites micro-fibrillaires par fibrillation in-situ : optimisation de la microstructure et des propriétés mécaniques résultantes : Elaboration and processing of micro-fibrillar composites by means of in-situ fibrillation : optimization of microstructure and mechanical properties. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2013. Available from: http://www.theses.fr/2013LIL10127

11. Dupretz, Renaud. Synthesis of novel phosphinate flame retardants for poly butylene(terephthalate) (PBT) and polyamide 6 (PA6) : Synthèse de nouveaux phosphinates retardateurs de flammes pour le poly(téréphtalate de butylène) et le polyamide 6.

Degree: Docteur es, Molécules et matière condensée, 2015, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2015LIL10193

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Cette étude s’intéresse aux procédés d’ignifugation de deux thermoplastiques techniques, le poly téréphtalate de butylène (PBT) et le polyamide 6 (PA6), à application dans le… (more)

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Cette étude s’intéresse aux procédés d’ignifugation de deux thermoplastiques techniques, le poly téréphtalate de butylène (PBT) et le polyamide 6 (PA6), à application dans le domaine électrique et électrotechnique. Plus précisément, l’accent est mis sur l’ajout en masse de retardateurs de flammes à base d’azote et de phosphore. L’objectif de ce projet consiste à préparer de nouveaux retardateurs de flamme par voie de synthèse organique. Dans un premier temps, cinq phosphinates d’aluminium ont été préparés par amidification de l’acide hydroxyphenylphosphoryl propanoïque et réaction avec un promoteur d’aluminium. Ces sels ont été incorporés au PBT et au PA6, seuls ou en combinaison avec des co-additifs, puis testés à l’UL-94, test témoin de la propagation verticale de la flamme, très utilisé dans l’industrie électrique et électrotechnique. Parmi les cinq sels, seul le phenylamide de l’acide hydroxyphenylphosphoryl propanoïque (PAS) s’est avéré être un retardateur de flammes efficace. D’autres tests ont été réalisés pour approfondir les résultats. Une instrumentation du test UL-94 a également été développée pour établir les bases de la compréhension du mécanisme d’action de la formulation, approfondies ensuite dans une série de microanalyses. Il a été démontré que le PAS se décompose en entraînant la scission des chaînes de PBT et le refroidissement du matériau. La libération de composés phosphorés en phase gaz, bien que moins efficace que pour d’autres composés commerciaux, suffit à donner à la formulation sa propriété d’auto-extinction.

This study deals with the flame retardancy of two engineering plastics, the poly(butylene terephthalate) (PBT) and the polyamide 6 (PA6), widely used in the electrical and electronic equipment (EEE). The focus is made on the incorporation of phosphorus- and nitrogen-containing flame retardant (FR) additives. The main goal of this project was to prepare novel FR through organic synthesis. Five aluminum phosphinates were prepared by reaction of amines on hydroxyphenylphosphnyl propanoic acid and an aluminum promoter. The salts were incorporated to PBT and PA6, with or without co-additives, and the materials were tested in the UL-94, test investigating the vertical propagation of the flame and widely used in the EEE industry. Among the five salts, only the aluminum salt of phenyl amide of hydroxyphenylphosphnyl propanoic acid showed outstanding properties as FR. Other tests were carried out, among which an instrumentation of the UL-94 test, to build a way to the comprehension of mechanisms. First observations were completed by various microanalyses. It has been shown that the decomposition of PAS enhances that of PBT in parallel to its cooling. The liberation of phosphorus-containing species in the gas-phase, despite les efficient than in the case of other commercial FR, gives the formulation its auto-extinguishing character.

Advisors/Committee Members: Bourbigot, Serge (thesis director), Duquesne, Sophie (thesis director).

Subjects/Keywords: Phosphinates; 668.423 5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dupretz, R. (2015). Synthesis of novel phosphinate flame retardants for poly butylene(terephthalate) (PBT) and polyamide 6 (PA6) : Synthèse de nouveaux phosphinates retardateurs de flammes pour le poly(téréphtalate de butylène) et le polyamide 6. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2015LIL10193

Chicago Manual of Style (16^th Edition):

Dupretz, Renaud. “Synthesis of novel phosphinate flame retardants for poly butylene(terephthalate) (PBT) and polyamide 6 (PA6) : Synthèse de nouveaux phosphinates retardateurs de flammes pour le poly(téréphtalate de butylène) et le polyamide 6.” 2015. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2015LIL10193.

MLA Handbook (7^th Edition):

Dupretz, Renaud. “Synthesis of novel phosphinate flame retardants for poly butylene(terephthalate) (PBT) and polyamide 6 (PA6) : Synthèse de nouveaux phosphinates retardateurs de flammes pour le poly(téréphtalate de butylène) et le polyamide 6.” 2015. Web. 04 Mar 2021.

Vancouver:

Dupretz R. Synthesis of novel phosphinate flame retardants for poly butylene(terephthalate) (PBT) and polyamide 6 (PA6) : Synthèse de nouveaux phosphinates retardateurs de flammes pour le poly(téréphtalate de butylène) et le polyamide 6. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2015. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2015LIL10193.

Council of Science Editors:

Dupretz R. Synthesis of novel phosphinate flame retardants for poly butylene(terephthalate) (PBT) and polyamide 6 (PA6) : Synthèse de nouveaux phosphinates retardateurs de flammes pour le poly(téréphtalate de butylène) et le polyamide 6. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2015. Available from: http://www.theses.fr/2015LIL10193

University of Ottawa

12. Luckhart, Christine. Functional Studies of the 5-HT1A Autoreceptor in Mice .

Degree: 2015, University of Ottawa

URL: http://hdl.handle.net/10393/31934

► The serotonin system, tightly controlled by negative regulation by 5-HT1A autoreceptors, is involved in MDD since manipulating different aspects of the 5-HT systems produces behavioral… (more)

Subjects/Keywords: 5-HT1A; Depression

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Luckhart, C. (2015). Functional Studies of the 5-HT1A Autoreceptor in Mice . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/31934

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Luckhart, Christine. “Functional Studies of the 5-HT1A Autoreceptor in Mice .” 2015. Thesis, University of Ottawa. Accessed March 04, 2021. http://hdl.handle.net/10393/31934.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Luckhart, Christine. “Functional Studies of the 5-HT1A Autoreceptor in Mice .” 2015. Web. 04 Mar 2021.

Vancouver:

Luckhart C. Functional Studies of the 5-HT1A Autoreceptor in Mice . [Internet] [Thesis]. University of Ottawa; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10393/31934.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Luckhart C. Functional Studies of the 5-HT1A Autoreceptor in Mice . [Thesis]. University of Ottawa; 2015. Available from: http://hdl.handle.net/10393/31934

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Sherry, Hani Mahmoud. Terahertz circuits and systems in CMOS : Circuits et systèmes Terahertz en CMOS.

Degree: Docteur es, Micro et nanotechnologies, acoustique et télécommunications, 2013, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2013LIL10049

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Cette thèse présente et analyse, à température ambiante, plusieurs circuits dédiés à la détection et à la génération de signaux Terahertz en technologies CMOS 65nm… (more)

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Cette thèse présente et analyse, à température ambiante, plusieurs circuits dédiés à la détection et à la génération de signaux Terahertz en technologies CMOS 65nm bulk et 28 nm FDSOI. Ces travaux présentent la méthodologie de conception de matrices de détecteurs intégrés. La réalisation en technologies CMOS permet d’étudier la faisabilité de ces circuits comme solutions commerciales potentielles pour diverses applications Terahertz. Le domaine Terahertz (300 GHz – 3 THz) présente des caractéristiques très intéressantes permettant de nombreuses applications : l’imagerie médicale non-invasive (détection de cellules cancéreuses, imagerie dentaire, pharmaceutique, etc), la détection de produits chimiques, les portiques de sécurité, l’astronomie, la communication ultra haut débit et bien d’autres encore. Cependant, ce domaine est également connu pour le faible nombre de sources et de détecteurs commerciaux, ce qui a conduit à le surnommer le fossé THz. Les systèmes THz classiques souffrent notamment du faible niveau d’intégration et des coûts de réalisation très importants. Par conséquent, les produits THz actuels sont limités par un très faible nombre de pixels pour produire une image cadencée aux THz. Or, contrairement à l’état de l’art, le développement de circuits THz pour des produits grand public nécessite un haut niveau d’intégration, un débit important, une basse consommation et une utilisation à température ambiante. Les technologies en Silicium utilisées dans la majorité des produits électroniques grand public, sont une solution attirante pour combler ce fossé. Ces travaux de thèse vont de l’analyse théorique à l’optimisation de détecteurs réalisés dans différentes technologies et topologies d’éclairage, jusqu’à la conception d’un imageur vidéo de 1k-pixels, incluant le multiplexage, l’amplification et le traitement du signal. La conception de sources Terahertz basées sur des oscillateurs harmoniques visant à atteindre la plus haute fréquence possible en technologie CMOS est montrée. Les imageurs Terahertz sont aussi discutés dans le contexte de leurs applications correspondantes, bilan de liaison et faisabilité.

This PhD dissertation presents and analyses various room-temperature circuits for Terahertz detection and generation implemented in CMOS 65nm bulk and 28nm FDSOI throughout the course of the thesis. The work discusses the methodology of design and feasibility of fully-integrated focal-plane arrays of detectors in CMOS technologies as potential commercial solutions for various THz applications. The interesting characteristics of the Terahertz portion (300GHz-3THz) of the Electromagnetic spectrum incite plenty of applications ranging from safe and non-invasive medical imaging (cancer detection, dental imaging, pharmaceutical and other), security screening and chemical detection, safety inspection and quality control, astronomy, ultra-high data-rate communications and many others. However, this region of the Electromagnetic spectrum has been dubbed the THz-Gap due to the lack of commercial sources and…

Advisors/Committee Members: Kaiser, Andreas (thesis director), Pfeiffer, Ullrich (thesis director).

Subjects/Keywords: Terahertz; 621.381 5

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APA (6^th Edition):

Sherry, H. M. (2013). Terahertz circuits and systems in CMOS : Circuits et systèmes Terahertz en CMOS. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2013LIL10049

Chicago Manual of Style (16^th Edition):

Sherry, Hani Mahmoud. “Terahertz circuits and systems in CMOS : Circuits et systèmes Terahertz en CMOS.” 2013. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2013LIL10049.

MLA Handbook (7^th Edition):

Sherry, Hani Mahmoud. “Terahertz circuits and systems in CMOS : Circuits et systèmes Terahertz en CMOS.” 2013. Web. 04 Mar 2021.

Vancouver:

Sherry HM. Terahertz circuits and systems in CMOS : Circuits et systèmes Terahertz en CMOS. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2013. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2013LIL10049.

Council of Science Editors:

Sherry HM. Terahertz circuits and systems in CMOS : Circuits et systèmes Terahertz en CMOS. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2013. Available from: http://www.theses.fr/2013LIL10049

University of Houston

14. -0662-2217. The Hierarchical Factor Structure of the Personality Inventory for DSM-5.

Degree: MA, Psychology, Clinical, 2019, University of Houston

URL: http://hdl.handle.net/10657/4692

► Section III of the DSM-5 contains a dimensional, trait-based Alternative Model for Personality Disorders (AMPD) as an area for future research, given proposals that a… (more)

▼ Section III of the DSM-5 contains a dimensional, trait-based Alternative Model for Personality Disorders (AMPD) as an area for future research, given proposals that a trait-based model of personality pathology may address inadequacies of the traditional categorical diagnostic model. Accompanying the AMPD is a trait-based, self-report measure of personality pathology – the Personality Inventory for DSM-5 (PID-5).The latent factor structure of the PID-5 is important given that it determines scoring procedures for the measure and helps inform the relationship between traits and the PD diagnoses in the AMPD, in other words, the latent structure of personality pathology. Therefore, it is necessary to consider this structure in great detail to ensure the structural validity and reliability of the measure and the AMPD moving forward. Against this background, the aim of the current study was to clarify the latent factor structure of the PID-5 using hierarchical confirmatory factor analysis (CFA) in a diverse, undergraduate student sample (N = 983). Results indicated that the majority of facet scales in the PID-5 were unidimensional. The psychoticism domain achieved acceptable model fit, but the others required modifications to achieve acceptable model fit. However, the entire hierarchical model of the PID-5 was not supported. Results of the current study call into question the hierarchical structure of the PID-5 for conceptualizing and assessing for personality pathology. Although domain scales of the PID-5 may reach acceptable levels of internal consistency and uni-dimensionality, the incremental utility of the domain scales over the facet scales in assessing for the presence of personality pathology remains in question. Further, the hierarchical structure of the PID-5 requires further investigation using item-level factor analytic techniques to compare alternative models to the structure proposed in the AMPD of the DSM-5. Advisors/Committee Members: Sharp, Carla (advisor), Ahmed, Yusra (committee member), Cirino, Paul T. (committee member), Steinberg, Lynne (committee member).

Subjects/Keywords: PID-5; Personality

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APA (6^th Edition):

-0662-2217. (2019). The Hierarchical Factor Structure of the Personality Inventory for DSM-5. (Masters Thesis). University of Houston. Retrieved from http://hdl.handle.net/10657/4692

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-0662-2217. “The Hierarchical Factor Structure of the Personality Inventory for DSM-5.” 2019. Masters Thesis, University of Houston. Accessed March 04, 2021. http://hdl.handle.net/10657/4692.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-0662-2217. “The Hierarchical Factor Structure of the Personality Inventory for DSM-5.” 2019. Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-0662-2217. The Hierarchical Factor Structure of the Personality Inventory for DSM-5. [Internet] [Masters thesis]. University of Houston; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10657/4692.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-0662-2217. The Hierarchical Factor Structure of the Personality Inventory for DSM-5. [Masters Thesis]. University of Houston; 2019. Available from: http://hdl.handle.net/10657/4692

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Universitat Rovira i Virgili

15. Vilavert Castellà, Lolita. Monitorització ambiental de contaminants químics i microbiològics a les rodalies de plantes de tractament de residus. Riscos per a la salut humana.

Degree: Departament de Ciències Mèdiques Bàsiques, 2011, Universitat Rovira i Virgili

URL: http://hdl.handle.net/10803/42937

► Incineration with or without energy recovery is likely to be an option for proper waste management, but public concern about incineration and the importance of… (more)

Subjects/Keywords: Contaminants Químics; 5

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APA (6^th Edition):

Vilavert Castellà, L. (2011). Monitorització ambiental de contaminants químics i microbiològics a les rodalies de plantes de tractament de residus. Riscos per a la salut humana. (Thesis). Universitat Rovira i Virgili. Retrieved from http://hdl.handle.net/10803/42937

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vilavert Castellà, Lolita. “Monitorització ambiental de contaminants químics i microbiològics a les rodalies de plantes de tractament de residus. Riscos per a la salut humana.” 2011. Thesis, Universitat Rovira i Virgili. Accessed March 04, 2021. http://hdl.handle.net/10803/42937.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vilavert Castellà, Lolita. “Monitorització ambiental de contaminants químics i microbiològics a les rodalies de plantes de tractament de residus. Riscos per a la salut humana.” 2011. Web. 04 Mar 2021.

Vancouver:

Vilavert Castellà L. Monitorització ambiental de contaminants químics i microbiològics a les rodalies de plantes de tractament de residus. Riscos per a la salut humana. [Internet] [Thesis]. Universitat Rovira i Virgili; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10803/42937.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vilavert Castellà L. Monitorització ambiental de contaminants químics i microbiològics a les rodalies de plantes de tractament de residus. Riscos per a la salut humana. [Thesis]. Universitat Rovira i Virgili; 2011. Available from: http://hdl.handle.net/10803/42937

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

16. Kosasih, Hansen Jayadi. Understanding the mechanism of ADAMTS-5 action.

Degree: 2015, University of Melbourne

URL: http://hdl.handle.net/11343/55780

► In arthritic diseases the articular cartilage is destroyed, resulting in a loss of the weight bearing properties of the joint. This destruction is mediated in… (more)

▼ In arthritic diseases the articular cartilage is destroyed, resulting in a loss of the weight bearing properties of the joint. This destruction is mediated in part by an enzyme called ADAMTS‐5, a member of the ADAMTS family (A Disintegrin And Metalloproteinase with ThromboSpondin motifs.) ADAMTS‐5 degrades aggrecan, the proteoglycan that enables cartilage to absorb water. ADAMTS‐5 is the major aggrecanase enzyme in mouse, and most likely the major aggrecanase in humans. ADAMTS‐5 is a multi‐domain enzyme, and the function of the C‐terminal ancillary domains is still under investigation. The aim of this study was to investigate how the C‐terminal ancillary domains modulate aggrecanolysis in vitro and in vivo. Two lines of ADAMTS‐5 deficient mice were available for comparison: one line, called TS5‐ΔCat, was made by an in‐frame deletion of exon 3 encoding the catalytic domain, whereas the other line, called TS5‐null, was made by introducing a premature stop codon in exon 2. Initial in vitro experiments showed that in heterozygous TS5‐ΔCat cartilage, the production of mutant ADAMTS‐5 protein lacking the catalytic domain, but with a full‐set of C‐terminal ancillary domains led to a inhibition of native ADAMTS‐5 activity, possibly via a dominant negative mechanism. No such mechanism operated in heterozygous TS5‐null cartilage. This led to the hypothesis that mutant TS5‐ΔCat protein interacts with, and inhibits native ADAMTS‐5, and prompted subsequent studies using recombinant human ADAMTS‐5 to determine the nature of the interaction. A cell line that co‐expressed C‐terminal FLAG‐tagged ADAMTS‐5 and C‐terminal c‐Myc-tagged ADAMTS‐5 was made. It was shown that both molecules interact with each other and co‐purify on immunoaffinity columns. Truncated ADAMTS‐5 constructs lacking the C-terminal ancillary domains were separately transfected into a cell‐line expressing a C-terminal‐tagged ADAMTS‐5. It was found that both the catalytic and the disintegrin‐like domains of ADAMTS‐5 were responsible for the ADAMTS‐5 intermolecular interaction. An in situ Proximity Ligation Assay showed that molecular interactions were likely to form intracellularly, within the secretory pathway. The nature of the interaction was subsequently investigated using cross‐linkers, as well as mass spectrometry analysis, and it was found that recombinant ADAMTS‐5 formed a higher order homo‐oligomer, with a molecular weight of ≥400kDa. Using zymography, it was shown that the oligomers were proteolytically more active than the monomers against a gelatin substrate. More importantly, data obtained from an aggrecan activity assay using recombinant full‐length ADAMTS‐5, with or without truncated ADAMTS‐5 species added as competitors, indicated that aggrecanolysis is reduced if oligomer formation is blocked. Next, a catalytically inactive recombinant ADAMTS‐5 mutant (E411A) was assessed for its potential to inhibit oligomerisation. The activity of recombinant full length ADAMTS‐5 against a fluorescencequenching substrate based on the brevican cleavage site was…

Subjects/Keywords: ADAMTS-5; arthritis

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APA (6^th Edition):

Kosasih, H. J. (2015). Understanding the mechanism of ADAMTS-5 action. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/55780

Chicago Manual of Style (16^th Edition):

Kosasih, Hansen Jayadi. “Understanding the mechanism of ADAMTS-5 action.” 2015. Doctoral Dissertation, University of Melbourne. Accessed March 04, 2021. http://hdl.handle.net/11343/55780.

MLA Handbook (7^th Edition):

Kosasih, Hansen Jayadi. “Understanding the mechanism of ADAMTS-5 action.” 2015. Web. 04 Mar 2021.

Vancouver:

Kosasih HJ. Understanding the mechanism of ADAMTS-5 action. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11343/55780.

Council of Science Editors:

Kosasih HJ. Understanding the mechanism of ADAMTS-5 action. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/55780

17. Bossard, Suzy. Précariat et rapports sociaux dans les métiers de service aux personnes : les auxiliaires de vie scolaire (AVS) dans l'Éducation nationale : Precariat and social relationships in people care jobs : special needs assistants (AVS) in French public schools.

Degree: Docteur es, Sociologie, 2015, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2015LIL12009

►

Cette thèse porte sur le métier d’auxiliaire de vie scolaire (AVS), d’accompagnante d’enfants en situation de handicap à l’école. Nous interrogeons à la fois l’emploi… (more)

▼

Cette thèse porte sur le métier d’auxiliaire de vie scolaire (AVS), d’accompagnante d’enfants en situation de handicap à l’école. Nous interrogeons à la fois l’emploi et le travail d’AVS tels qu’ils ont été organisés et mis en pratique depuis 2003. L’analyse du métier d’AVS est multiscalaire – macro, méso et microsocial – et multidimensionnelle – politiques publiques, recrutement, trajectoires, contenu du travail prescrit et effectif, conditions d’emploi et de travail, mobilisations. L’analyse prend place à l’intersection de trois sociologies : des services aux personnes, de la précarité et des rapports sociaux. Elle est menée grâce à une enquête ethnographique qui explore deux terrains différents à partir d’observations, d’entretiens et d’analyses de documents administratifs et législatifs. L’ensemble montre que le métier d’AVS est ancré dans une division sexuelle et sociale du travail de service aux personnes et qu’il participe au développement du précariat. Plus spécifiquement, la thèse fait émerger trois résultats principaux. D’abord, les conditions de travail et d’emploi font système : les unes ne peuvent entièrement se comprendre sans les autres. Ensuite, le métier d’AVS est un métier de service aux personnes : il structure et est structuré par une division sexuelle du travail par laquelle le groupe des femmes est assigné aux tâches de service aux personnes. Enfin, notre troisième résultat est une contribution au concept de précariat : nous montrons que le précariat renouvelle une classe servile à travers les services aux personnes et les formes particulières d’emplois qui y sont associées.

The dissertation focuses on the special needs assistants (AVS) profession, occupation which consists in helping disabled children during school time. It questions both the specific forms of work and employment of the AVS that have been organized and implemented in France since 2003. The analysis is carried at the micro, meso and macrosocial level, and it is multidimensional, focusing on public policies, recruitment, career-path, effective and assigned task content, and mobilization. Three types of sociology are used to carry the analysis: people care, precariat and social relationships. The study is based on an ethnographic survey carried on two different observation fields and which relies on observations, interviews and on administrative and legislative documents. It is shown that the AVS profession takes its roots in a social and sexual work division of care, and that it contributes to the expansion of precariat. More specifically, we draw three main conclusions. First, work and employment conditions form a system: neither can be fully understood without the other. Then, special needs assistants belong to the field of people care: it both structures and is structured by a sexual division of work through which women are assigned to people care tasks. Finally, the third result is a contribution to the precariat concept: it is shown that precariat renews a servile class through people care jobs and through the specific…

Advisors/Committee Members: Cresson, Geneviève (thesis director).

Subjects/Keywords: Précariat; 306.361 5

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APA (6^th Edition):

Bossard, S. (2015). Précariat et rapports sociaux dans les métiers de service aux personnes : les auxiliaires de vie scolaire (AVS) dans l'Éducation nationale : Precariat and social relationships in people care jobs : special needs assistants (AVS) in French public schools. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2015LIL12009

Chicago Manual of Style (16^th Edition):

Bossard, Suzy. “Précariat et rapports sociaux dans les métiers de service aux personnes : les auxiliaires de vie scolaire (AVS) dans l'Éducation nationale : Precariat and social relationships in people care jobs : special needs assistants (AVS) in French public schools.” 2015. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2015LIL12009.

MLA Handbook (7^th Edition):

Bossard, Suzy. “Précariat et rapports sociaux dans les métiers de service aux personnes : les auxiliaires de vie scolaire (AVS) dans l'Éducation nationale : Precariat and social relationships in people care jobs : special needs assistants (AVS) in French public schools.” 2015. Web. 04 Mar 2021.

Vancouver:

Bossard S. Précariat et rapports sociaux dans les métiers de service aux personnes : les auxiliaires de vie scolaire (AVS) dans l'Éducation nationale : Precariat and social relationships in people care jobs : special needs assistants (AVS) in French public schools. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2015. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2015LIL12009.

Council of Science Editors:

Bossard S. Précariat et rapports sociaux dans les métiers de service aux personnes : les auxiliaires de vie scolaire (AVS) dans l'Éducation nationale : Precariat and social relationships in people care jobs : special needs assistants (AVS) in French public schools. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2015. Available from: http://www.theses.fr/2015LIL12009

University of Cambridge

18. Hardisty, Robyn Elizabeth. Methods to Probe the Function of Modified Bases in DNA.

Degree: PhD, 2017, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/271807

► This thesis is focused on the development and utilisation of chemical and biological tools to probe the function of modified bases in DNA with specific… (more)

▼ This thesis is focused on the development and utilisation of chemical and biological tools to probe the function of modified bases in DNA with specific exploration of the less well-studied T-modifications: 5-hmU, 5-fU and Base J. LCMS/MS techniques are first utilised to enable the accurate global quantification of T-modifications (5-hmU, 5-fU and Base J) in both trypanosomatids and mammalian DNA. A chemical affinity-enrichment sequencing method for the T-modifications is next described, which allows their chemoselective tagging over their C-modification counterparts. DNA fragments containing 5-fU are selectively tagged and enriched via oxime, hydrazine or benzimidazole formation using a biotinylated probe, and DNA fragments containing 5-hmU can be first chemically oxidised to 5-fU using KRuO4. .Proof-of-principle T-modification enrichment is demonstrated by DNA sequencing. In the following chapter, sequencing methods are employed to investigate the role of T-modifications in both trypanosomatids and mammalian samples. In T.Brucei, Base J formation is probed by artificial incorporation of 5-hmU and subsequent Base J chemical sequencing. Base J is preferentially formed or depleted at certain genomic loci; suggesting that Base J formation is sequence-specific. This may imply a distinct role for the 5-hmU sites which are not further glucosylated. Next, 5-hmU enrichment sequencing is performed in SMUG1 knockdown HEK293T cells to determine the genomic location of 5-hmU in mammals. An increase in 5-hmU loci is observed upon SMUG1 knockdown. 5-hmU enriched regions are found to be T-rich and depleted in exons and promoters. Furthermore, 5-hmU sites show poor overlap with known TET-enzyme binding sites, indicating that 5-hmU is formed via a TET-independent mechanism in HEK293T cells. Next, mass spectrometry-based proteomics studies are utilised to determine 5-fU protein-binders in mammals. Pulldown of proteins using biotinylated baits enables the identification of proteins which are enriched or suppressed in the presence of the 5-fU modification compared to a non-modified control. Enriched proteins include those associated with DNA-damage, consistent with the current understanding that 5-fU is a product of oxidative damage in mammalian DNA. Finally, a mechanistic insight into the effect of formylated bases on nucleosomal structure is described. Schiff base formation between formylated nucleobases and histone protein lysine side-chains is demonstrated. This provides a molecular mechanism for the association of 5-fC with increased nucleosomal occupancy in vivo.

Subjects/Keywords: DNA; modified bases; epigenetics; 5-hydroxymethyluracil; 5-formyluracil; 5-formylcytosine

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APA (6^th Edition):

Hardisty, R. E. (2017). Methods to Probe the Function of Modified Bases in DNA. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/271807

Chicago Manual of Style (16^th Edition):

Hardisty, Robyn Elizabeth. “Methods to Probe the Function of Modified Bases in DNA.” 2017. Doctoral Dissertation, University of Cambridge. Accessed March 04, 2021. https://www.repository.cam.ac.uk/handle/1810/271807.

MLA Handbook (7^th Edition):

Hardisty, Robyn Elizabeth. “Methods to Probe the Function of Modified Bases in DNA.” 2017. Web. 04 Mar 2021.

Vancouver:

Hardisty RE. Methods to Probe the Function of Modified Bases in DNA. [Internet] [Doctoral dissertation]. University of Cambridge; 2017. [cited 2021 Mar 04]. Available from: https://www.repository.cam.ac.uk/handle/1810/271807.

Council of Science Editors:

Hardisty RE. Methods to Probe the Function of Modified Bases in DNA. [Doctoral Dissertation]. University of Cambridge; 2017. Available from: https://www.repository.cam.ac.uk/handle/1810/271807

University of Edinburgh

19. Stevenson, Paula Louise. Role of 5-ht2c receptor density on behaviour in mice.

Degree: PhD, 2011, University of Edinburgh

URL: http://hdl.handle.net/1842/5570

► The neurotransmitters serotonin (5-HT) and dopamine (DA) play roles in eating disorders, mood disorders, such as depression and anxiety, and in the regulation of locomotion.… (more)

▼ The neurotransmitters serotonin (5-HT) and dopamine (DA) play roles in eating disorders, mood disorders, such as depression and anxiety, and in the regulation of locomotion. The 5-HT2C receptor is one of fourteen 5-HT receptor subtypes that is expressed in regions of the brain including the hippocampus, amygdala, dorsal striatum, nucleus accumbens (NA) and substantia nigra, and is therefore implicated in behaviours and disorders associated with these regions. 5-HT has been shown to exert both a tonic and phasic inhibitory control, through the 5-HT2C receptor, on the firing rate and bursting activity of DA-containing neurones in the ventral tegmental area which enhances DA release in the NA and prefrontal cortex. In addition, the 5-HT2C receptor is under the control of a monophasic diurnal rhythm and is in a position to alter circadian regulation and behaviour due to its expression in the suprachiasmatic nucleus (the light entrainable oscillator (LEO)). It was hypothesised that elevating expression of the 5-HT2C receptor would have a detrimental effect on mood and cause hypolocomotion while reducing 5-HT2C receptor expression would improve mood, cause hyperphagia, obesity and hyperlocomotion. In order to investigate these hypotheses mouse models that either over- or under-expressed the 5-HT2C receptor were implemented. The 5-HT2C receptor expression pattern and levels were confirmed in all mouse lines. A behavioural phenotype of hypolocomotion and increased anxiety in the 5-HT2C receptor over-expressing mice and hyperphagia, obesity and hyperlocomotion in the 5-HT2C receptor under-expressing mice were found the latter is conistent with current literature. During backcrossing of the mouse lines onto the C57Bl/6 genetic background the abnormal behavioural phenotypes were lost suggesting that 5-HT2C receptor function is particulary sensitive to the genetic background on which it is being expressed. In response to altered expression levels of 5-HT2C receptor, compensatory alterations were found in the 5-HT system, with an inverse relationship existing between both the 5-HT1A receptor mRNA expression levels and 5-HT release in the hippocampus with the expression levels of the 5-HT2C receptor. Over-expression of 5-HT2C receptor appears to inhibit DA release in the cortex. The circadian experiments showed that under-expressing the 5-HT2C receptor did not alter the regulation of the food entrainable oscillator and there was a suggestion that the regulation of the LEO was affected. In summary, these results demonstrate that altered expression of 5-HT2C receptors results in abnormal behaviours consistent with its role in psychiatric disorders, but that the outcome is dependent on the genetic background.

Subjects/Keywords: 616.89; 5-HT; 5-HT2C; 5-HT2C receptors; dopamine

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APA (6^th Edition):

Stevenson, P. L. (2011). Role of 5-ht2c receptor density on behaviour in mice. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/5570

Chicago Manual of Style (16^th Edition):

Stevenson, Paula Louise. “Role of 5-ht2c receptor density on behaviour in mice.” 2011. Doctoral Dissertation, University of Edinburgh. Accessed March 04, 2021. http://hdl.handle.net/1842/5570.

MLA Handbook (7^th Edition):

Stevenson, Paula Louise. “Role of 5-ht2c receptor density on behaviour in mice.” 2011. Web. 04 Mar 2021.

Vancouver:

Stevenson PL. Role of 5-ht2c receptor density on behaviour in mice. [Internet] [Doctoral dissertation]. University of Edinburgh; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1842/5570.

Council of Science Editors:

Stevenson PL. Role of 5-ht2c receptor density on behaviour in mice. [Doctoral Dissertation]. University of Edinburgh; 2011. Available from: http://hdl.handle.net/1842/5570

University of Cambridge

20. Hardisty, Robyn Elizabeth. Methods to probe the function of modified bases in DNA.

Degree: PhD, 2017, University of Cambridge

URL: https://doi.org/10.17863/CAM.18804 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744429

► This thesis is focused on the development and utilisation of chemical and biological tools to probe the function of modified bases in DNA with specific… (more)

▼ This thesis is focused on the development and utilisation of chemical and biological tools to probe the function of modified bases in DNA with specific exploration of the less well-studied T-modifications: 5-hmU, 5-fU and Base J. LCMS/MS techniques are first utilised to enable the accurate global quantification of T-modifications (5-hmU, 5-fU and Base J) in both trypanosomatids and mammalian DNA. A chemical affinity-enrichment sequencing method for the T-modifications is next described, which allows their chemoselective tagging over their C-modification counterparts. DNA fragments containing 5-fU are selectively tagged and enriched via oxime, hydrazine or benzimidazole formation using a biotinylated probe, and DNA fragments containing 5-hmU can be first chemically oxidised to 5-fU using KRuO4. .Proof-of-principle T-modification enrichment is demonstrated by DNA sequencing. In the following chapter, sequencing methods are employed to investigate the role of T-modifications in both trypanosomatids and mammalian samples. In T.Brucei, Base J formation is probed by artificial incorporation of 5-hmU and subsequent Base J chemical sequencing. Base J is preferentially formed or depleted at certain genomic loci; suggesting that Base J formation is sequence-specific. This may imply a distinct role for the 5-hmU sites which are not further glucosylated. Next, 5-hmU enrichment sequencing is performed in SMUG1 knockdown HEK293T cells to determine the genomic location of 5-hmU in mammals. An increase in 5-hmU loci is observed upon SMUG1 knockdown. 5-hmU enriched regions are found to be T-rich and depleted in exons and promoters. Furthermore, 5-hmU sites show poor overlap with known TET-enzyme binding sites, indicating that 5-hmU is formed via a TET-independent mechanism in HEK293T cells. Next, mass spectrometry-based proteomics studies are utilised to determine 5-fU protein-binders in mammals. Pulldown of proteins using biotinylated baits enables the identification of proteins which are enriched or suppressed in the presence of the 5-fU modification compared to a non-modified control. Enriched proteins include those associated with DNA-damage, consistent with the current understanding that 5-fU is a product of oxidative damage in mammalian DNA. Finally, a mechanistic insight into the effect of formylated bases on nucleosomal structure is described. Schiff base formation between formylated nucleobases and histone protein lysine side-chains is demonstrated. This provides a molecular mechanism for the association of 5-fC with increased nucleosomal occupancy in vivo.

Subjects/Keywords: 572.8; DNA; modified bases; epigenetics; 5-hydroxymethyluracil; 5-formyluracil; 5-formylcytosine

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APA (6^th Edition):

Hardisty, R. E. (2017). Methods to probe the function of modified bases in DNA. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.18804 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744429

Chicago Manual of Style (16^th Edition):

Hardisty, Robyn Elizabeth. “Methods to probe the function of modified bases in DNA.” 2017. Doctoral Dissertation, University of Cambridge. Accessed March 04, 2021. https://doi.org/10.17863/CAM.18804 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744429.

MLA Handbook (7^th Edition):

Hardisty, Robyn Elizabeth. “Methods to probe the function of modified bases in DNA.” 2017. Web. 04 Mar 2021.

Vancouver:

Hardisty RE. Methods to probe the function of modified bases in DNA. [Internet] [Doctoral dissertation]. University of Cambridge; 2017. [cited 2021 Mar 04]. Available from: https://doi.org/10.17863/CAM.18804 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744429.

Council of Science Editors:

Hardisty RE. Methods to probe the function of modified bases in DNA. [Doctoral Dissertation]. University of Cambridge; 2017. Available from: https://doi.org/10.17863/CAM.18804 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744429

Universidade Federal de Santa Maria

21. Daniel Ricardo Rissi. EPIDEMIOLOGIA, SINAIS CLÍNICOS E DISTRIBUIÇÃO DAS LESÕES ENCEFÁLICAS EM BOVINOS AFETADOS POR MENINGOENCEFALITE POR HERPESVÍRUS BOVINO-5 (BoHV-5).

Degree: 2007, Universidade Federal de Santa Maria

URL: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1332

►

São descritos sete surtos e um caso isolado de meningoencefalite por herpesvírus bovino-5 (BoHV-5) em bovinos no Rio Grande do Sul entre 2002-2004. Foram afetados… (more)

▼

São descritos sete surtos e um caso isolado de meningoencefalite por herpesvírus bovino-5 (BoHV-5) em bovinos no Rio Grande do Sul entre 2002-2004. Foram afetados bovinos de 1-18 meses, de diversas raças e ambos os sexos. A maior freqüência foi observada em bovinos recém-desmamados e submetidos a outros fatores de estresse. Nesses surtos, de uma população total sob risco de 1.359 bovinos, 54 foram afetados, quatro se recuperaram e 50 morreram espontaneamente ou foram submetidos à eutanásia quando moribundos. Os índices gerais de morbidade, mortalidade e letalidade foram, respectivamente, de 3,97%, 3,67% e 92,59%. A evolução clínica variou de 3-10 dias e os sinais eram caracterizados por depressão, corrimento nasal ou ocular, ranger de dentes, andar em círculos, cegueira, febre, nistagmo, tremores, anorexia, disfagia, sialorréia, incoordenação, pressão da cabeça contra objetos, pêlos arrepiados, taquicardia, taquipnéia, dor abdominal, melena, quedas, decúbito, opistótono, convulsões e movimentos de pedalagem. Dezenove bezerros foram necropsiados. Achados de necropsia foram caracterizados por hiperemia das leptomeninges, tumefação das porções rostrais do telencéfalo, com achatamento das circunvoluções dos lobos frontais; nessas áreas havia focos marromamarelados e amolecidos (malacia). Nos casos de evolução clínica mais longa era observada acentuada tumefação, amolecimento e extensas áreas de hemorragia nos lobos frontais telencefálicos. Microscopicamente, todos os bovinos afetados apresentaram meningoencefalite não-supurativa e necrosante, que variou quanto à localização e intensidade nos 19 casos examinados e nas seções de encéfalo de um mesmo caso. A intensidade dessas lesões foi mais acentuada, em ordem decrescente, no córtex telencefálico frontal, nos núcleos da base, tálamo, tronco encefálico, córtex parietal, córtex occipital e cerebelo. O infiltrado inflamatório perivascular era constituído predominantemente por linfócitos e plasmócitos e, menos freqüentemente, neutrófilos. Outros achados incluíam variados graus de gliose, edema, necrose neuronal no córtex telencefálico, caracterizada por encarquilhamento e eosinofilia do citoplasma e picnose nuclear (neurônio vermelho), corpúsculos de inclusão basofílicos intranucleares em astrócitos e neurônios (21,05% dos casos), satelitose e neuronofagia. As áreas de amolecimento do parênquima eram caracterizadas por necrose do componente neuroectodérmico e manutenção das estruturas mesenquimais (vasos e micróglia), com infiltrado de células gitter e, em casos mais graves, áreas de hemorragia. Nos casos crônicos apenas estruturas vasculares e poucas células gitter permaneciam, formando uma cavidade entre a substância branca e as leptomeninges (lesão residual). O diagnóstico foi realizado com base nos achados epidemiológicos, clínicos, de necropsia e histopatológicos. Adicionalmente, foi realizado isolamento viral, imunofluorescência e reação em cadeia da polimerase em três surtos.

Seven outbreaks and an isolated case of meningoencephalitis caused by bovine herpesvirus-5…

Advisors/Committee Members: Ana Lucia Pereira Schild, David Driemeier, Claudio Severo Lombardo de Barros.

Subjects/Keywords: neuropatologia; doenças de bovinos; doenças virais; meningoencefalite; BoHV-5; BHV-5; herpesvírus bovino-5; MEDICINA VETERINARIA; BHV-5; bovine herpesvirus-5; BoHV-5; meningoencephalitis; viral diseases; diseases of cattle; neuropathology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rissi, D. R. (2007). EPIDEMIOLOGIA, SINAIS CLÍNICOS E DISTRIBUIÇÃO DAS LESÕES ENCEFÁLICAS EM BOVINOS AFETADOS POR MENINGOENCEFALITE POR HERPESVÍRUS BOVINO-5 (BoHV-5). (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1332

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rissi, Daniel Ricardo. “EPIDEMIOLOGIA, SINAIS CLÍNICOS E DISTRIBUIÇÃO DAS LESÕES ENCEFÁLICAS EM BOVINOS AFETADOS POR MENINGOENCEFALITE POR HERPESVÍRUS BOVINO-5 (BoHV-5).” 2007. Thesis, Universidade Federal de Santa Maria. Accessed March 04, 2021. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1332.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rissi, Daniel Ricardo. “EPIDEMIOLOGIA, SINAIS CLÍNICOS E DISTRIBUIÇÃO DAS LESÕES ENCEFÁLICAS EM BOVINOS AFETADOS POR MENINGOENCEFALITE POR HERPESVÍRUS BOVINO-5 (BoHV-5).” 2007. Web. 04 Mar 2021.

Vancouver:

Rissi DR. EPIDEMIOLOGIA, SINAIS CLÍNICOS E DISTRIBUIÇÃO DAS LESÕES ENCEFÁLICAS EM BOVINOS AFETADOS POR MENINGOENCEFALITE POR HERPESVÍRUS BOVINO-5 (BoHV-5). [Internet] [Thesis]. Universidade Federal de Santa Maria; 2007. [cited 2021 Mar 04]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1332.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rissi DR. EPIDEMIOLOGIA, SINAIS CLÍNICOS E DISTRIBUIÇÃO DAS LESÕES ENCEFÁLICAS EM BOVINOS AFETADOS POR MENINGOENCEFALITE POR HERPESVÍRUS BOVINO-5 (BoHV-5). [Thesis]. Universidade Federal de Santa Maria; 2007. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1332

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

22. Píštěk, Petr. Parametrická studie pozemní komunikace: Parametric study of road communications.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/84666

► The goal of the bachelor’s thesis is a parametric study of a road Uherský Ostroh - Hluk. Both vilages are situated in Zlin region. It… (more)

Subjects/Keywords: Parametrická studie; Hluk; Uherský Ostroh; extravilán; S7; 5; S9; 5; S11; 5; Parametric study; Hluk; Uherský Ostroh; extra region; S7; 5; S9; 5; S11; 5

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APA (6^th Edition):

Píštěk, P. (2019). Parametrická studie pozemní komunikace: Parametric study of road communications. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/84666

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Píštěk, Petr. “Parametrická studie pozemní komunikace: Parametric study of road communications.” 2019. Thesis, Brno University of Technology. Accessed March 04, 2021. http://hdl.handle.net/11012/84666.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Píštěk, Petr. “Parametrická studie pozemní komunikace: Parametric study of road communications.” 2019. Web. 04 Mar 2021.

Vancouver:

Píštěk P. Parametrická studie pozemní komunikace: Parametric study of road communications. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11012/84666.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Píštěk P. Parametrická studie pozemní komunikace: Parametric study of road communications. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/84666

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Paltatzidou, Kiriaki. Συγκριτική μελέτη θεραπείας χηλοειδών με 5 - φθοριουρακίλη, κρυοχειρουργικής και συνδυασμών αυτών με τη χρήση ανοσοϊστοχημικών τεχνικών.

Degree: 2018, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/43284

► SummaryObjectivesKeloids are a type of benign proliferative fibromas that form following trauma. Metalloproteinase-9 (MMP-9), produced in multinuclear giant cells,1 is considered a subclass of the… (more)

▼ SummaryObjectivesKeloids are a type of benign proliferative fibromas that form following trauma. Metalloproteinase-9 (MMP-9), produced in multinuclear giant cells,1 is considered a subclass of the MMPs (a family of zinc-dependent endopeptidases), and is involved in processes that occur during cutaneous wound healing such as, inflammation matrix remodelling and epithelization. The activity of MMP-9 has been shown to be critical for several of these processes in the content of pathological conditions, such as hypertrophic scars and keloids. In addition, a pyrimidine analogue with antimetabolite activity, 5-fluorouracil,when given intralesionally, is an alternative therapy for keloids.Intralesional cryotherapy is a technique for treatment of keloids which can have uncomfortable side-effects like, pain, oedema, infections, hypoesthesia, milium cyst formation, necrosis and persistent hypopigmentation. In this study we investigated the effect of three different keloid treatments in immunoreactivity of MMP-9 in multinuclear giant cells in skin keloids. Material and methodForty five patients were enrolled in this study. Pregnant women, women planning pregnancy in the near future, patients with chronic renal failure or abnormal liver function tests or full blood count were excluded from the study. All patients were treatment naıve. The study consisted of three treatment arms, as described below:•5-Fluorouracil (5-FU) arm: Fifteen patients were treated once weekly with intralesional 5-FU 50 mg/cc. The delivered dose was adjusted according to the extent of the lesions, and did not exceed 100 mg per session (2 cc). The solution was injected using a 27-gauge needle until slight blanching was clinically visible. Only the indurated parts of the keloids were treated by multiple injections, separated by 1 cm approximately.•Cryotherapy arms: Fifteen patients were treated once monthly with intralesional cryotherapy. •Combination arm: Fifteen patients were treated once monthly with intralesional 5-FU plus cryotherapy.Lesional skin biopsies were taken from patients with skin keloids, before introduction of any treatment and after treatments, to assess the MMP-9 immunohistochemical result.Immunochemistry stain of MMP-9 was carried out using monoclonal antibody DACO (anti-MMP-9 from DAKOAO150) as described in Marzano et al., 2010.Two independent blind observers evaluated the serial sections. Immunoreactivity was scored according to the number of immunoreactive cells per field (9200), as follows: 0 = no immunoreactive cells; 1 = 1–5 cells; 2 = 6–20 cells; 3 = ≥20 cells. A P-value of <0.05 was considered to indicate a statistically significant difference. ResultsMMP-9 was expressed strongly at the multinuclear giant cells of keloid biopsies. The score according to the number of immunoreactive multinuclear giant cells between pre and post treatment was significantly decreased in the three therapies (P < 0.05).The specific role of MMP-9 in normal healing is not known. It has been reported that MMP-9 is present during normal healing for the…

Subjects/Keywords: Χηλοειδή; 5-φθοριουρακίλη; Μεταλλοπρωτεϊνάση-9; Κρυοθεραπεία; Keloids; MMP-9; 5-FU; Cryotherapy; 5-Fluoruracil

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Paltatzidou, K. (2018). Συγκριτική μελέτη θεραπείας χηλοειδών με 5 - φθοριουρακίλη, κρυοχειρουργικής και συνδυασμών αυτών με τη χρήση ανοσοϊστοχημικών τεχνικών. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/43284

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Paltatzidou, Kiriaki. “Συγκριτική μελέτη θεραπείας χηλοειδών με 5 - φθοριουρακίλη, κρυοχειρουργικής και συνδυασμών αυτών με τη χρήση ανοσοϊστοχημικών τεχνικών.” 2018. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 04, 2021. http://hdl.handle.net/10442/hedi/43284.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Paltatzidou, Kiriaki. “Συγκριτική μελέτη θεραπείας χηλοειδών με 5 - φθοριουρακίλη, κρυοχειρουργικής και συνδυασμών αυτών με τη χρήση ανοσοϊστοχημικών τεχνικών.” 2018. Web. 04 Mar 2021.

Vancouver:

Paltatzidou K. Συγκριτική μελέτη θεραπείας χηλοειδών με 5 - φθοριουρακίλη, κρυοχειρουργικής και συνδυασμών αυτών με τη χρήση ανοσοϊστοχημικών τεχνικών. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10442/hedi/43284.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Paltatzidou K. Συγκριτική μελέτη θεραπείας χηλοειδών με 5 - φθοριουρακίλη, κρυοχειρουργικής και συνδυασμών αυτών με τη χρήση ανοσοϊστοχημικών τεχνικών. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. Available from: http://hdl.handle.net/10442/hedi/43284

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Johannes Gutenberg Universität Mainz

24. Herth, Matthias. Synthesis and evaluation of 18-F-radiopharmaceuticals within the serotonergic receptor system for molecular imaging.

Degree: 2009, Johannes Gutenberg Universität Mainz

URL: http://ubm.opus.hbz-nrw.de/volltexte/2009/1998/

►

Molecular imaging technologies as Positron Emission Tomography (PET) are playing a key role in drug discovery, development and delivery due to the possibility to quantify… (more)

▼

Molecular imaging technologies as Positron Emission Tomography (PET) are playing a key role in drug discovery, development and delivery due to the possibility to quantify e.g. the binding potential in vivo, non-invasively and repetitively. In this context, it provides a significant advance in the understanding of many CNS disorders and conditions. The serotonergic receptor system is involved in a number of important physiological processes and diseases such as depression, schizophrenia, Alzheimer’s disease, sleep or sexual behaviour. Especially, the 5-HT2A and the 5-HT1A receptor subtypes are in the focus of fundamental and clinical research due to the fact that many psychotic drugs interact with these neuronal transmembrane receptors. This work describes the successful development, as well as in vitro and in vivo evaluation of 5-HT2A and 5-HT1A selective antagonistic PET-radiotracers. The major achievements obtained in this thesis are: 1. the development and in vitro evaluation of several 5-HT2A antagonistic compounds, namely MH.MZ (Ki = 9.0 nM), (R)-MH.MZ (Ki = 0.72 nM) and MA-1 (Ki = 3.0 nM). 2. the 18F-labeling procedure of these compounds and their optimization, whereby radiochemical yields > 35 % in high specific activities (> 15 GBq/µmol) could be observed. Synthesis time inclusive secondary synthon synthesis, the radioactive labeling procedure, separation and final formulation took no longer than 120 min and provided the tracer in high radiochemical purity. 3. the in vivo µPET evaluation of [18F]MH.MZ and (R)-[18F]MH.MZ resulting in promising imaging agents of the 5-HT2A receptor status; from which (R)-[18F]MH.MZ seems to be the most promising ligand. 4. the determination of the influence of P-gp on the brain biodistribution of [18F]MH.MZ showing a strong P-gp dependency but no regional alteration. 5. the four-step radiosynthesis and evaluation of [18F]MDL 100907 resulting in another high affine tracer, which is, however, limited due to its low radiochemical yield. 6. the development and evaluation of 3 novel possible 5-HT2A imaging agents combining structural elements of altanserin, MDL 100907 and SR 46349B demonstrating different binding modes of these compounds. 7. the development, the labeling and in vitro evaluation of the novel 5-HT1A antagonistic tracer [18F]AH1.MZ (Ki = 4.2 nM).

Molekular bildgebende Verfahren wie die Positronen-Emissions-Tomography (PET) spielen eine wichtige Rolle bei vielen biologischen und medizinischen Fragestellungen. Dabei kann die PET in vivo, wiederholbar und nicht-invasiv z.B. das Bindungspotential von Tracern bestimmen und somit zu einem besseren Verständnis z.B. von neurologischen Krankheiten oder mentalen Zuständen dienen. Das serotonerge System ist an vielen physiologischen Prozessen und Krankheiten beteiligt. Besondere Bedeutung kommt dem 5-HT2A und dem 5-HT1A Rezeptorsubtypen zu. Viele Antipsychotika interagieren mit diesen Rezeptor-untereinheiten. Diese Arbeit befasst sich mit der erfolgreichen Entwicklung, der in vitro und in vivo Evaluierung von…

Subjects/Keywords: MDL 100907, MH.MZ, 5-HT2A, 5-HT1A; MDL 100907, MH.MZ, 5-HT2A, 5-HT1A; Chemistry and allied sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herth, M. (2009). Synthesis and evaluation of 18-F-radiopharmaceuticals within the serotonergic receptor system for molecular imaging. (Doctoral Dissertation). Johannes Gutenberg Universität Mainz. Retrieved from http://ubm.opus.hbz-nrw.de/volltexte/2009/1998/

Chicago Manual of Style (16^th Edition):

Herth, Matthias. “Synthesis and evaluation of 18-F-radiopharmaceuticals within the serotonergic receptor system for molecular imaging.” 2009. Doctoral Dissertation, Johannes Gutenberg Universität Mainz. Accessed March 04, 2021. http://ubm.opus.hbz-nrw.de/volltexte/2009/1998/.

MLA Handbook (7^th Edition):

Herth, Matthias. “Synthesis and evaluation of 18-F-radiopharmaceuticals within the serotonergic receptor system for molecular imaging.” 2009. Web. 04 Mar 2021.

Vancouver:

Herth M. Synthesis and evaluation of 18-F-radiopharmaceuticals within the serotonergic receptor system for molecular imaging. [Internet] [Doctoral dissertation]. Johannes Gutenberg Universität Mainz; 2009. [cited 2021 Mar 04]. Available from: http://ubm.opus.hbz-nrw.de/volltexte/2009/1998/.

Council of Science Editors:

Herth M. Synthesis and evaluation of 18-F-radiopharmaceuticals within the serotonergic receptor system for molecular imaging. [Doctoral Dissertation]. Johannes Gutenberg Universität Mainz; 2009. Available from: http://ubm.opus.hbz-nrw.de/volltexte/2009/1998/

25. DONATO, Mariana Aragão Matos. Avaliação dos efeitos do inibidor de fosfodiesterase 5 sobre a ovogênese de camundongos .

Degree: 2009, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/1624

► O Vardenafil é um potente vasodilatador, com uso no tratamento de pacientes com disfunção erétil. Seu mecanismo de ação baseia-se na inibição seletiva da fosfodiesterase-5… (more)

Subjects/Keywords: Fosfodiesterase-5; iPDE5; Enzimas

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APA (6^th Edition):

DONATO, M. A. M. (2009). Avaliação dos efeitos do inibidor de fosfodiesterase 5 sobre a ovogênese de camundongos . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/1624

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DONATO, Mariana Aragão Matos. “Avaliação dos efeitos do inibidor de fosfodiesterase 5 sobre a ovogênese de camundongos .” 2009. Thesis, Universidade Federal de Pernambuco. Accessed March 04, 2021. http://repositorio.ufpe.br/handle/123456789/1624.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DONATO, Mariana Aragão Matos. “Avaliação dos efeitos do inibidor de fosfodiesterase 5 sobre a ovogênese de camundongos .” 2009. Web. 04 Mar 2021.

Vancouver:

DONATO MAM. Avaliação dos efeitos do inibidor de fosfodiesterase 5 sobre a ovogênese de camundongos . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2009. [cited 2021 Mar 04]. Available from: http://repositorio.ufpe.br/handle/123456789/1624.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DONATO MAM. Avaliação dos efeitos do inibidor de fosfodiesterase 5 sobre a ovogênese de camundongos . [Thesis]. Universidade Federal de Pernambuco; 2009. Available from: http://repositorio.ufpe.br/handle/123456789/1624

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Haykal, Imane. Spectroscopie millimétrique et submilimétrique de molécules astrophysiques : application au Formiate de Méthyle, au Glycolaldéhyde et à l’Isocyanure d’Allyle : Millimeter and submillimeter wave spectroscopy of astrophysical molecules : application to Methylformate, Glycolaldehyde and Allylisocyanide.

Degree: Docteur es, Optique et lasers, Physico-chimie, Atmosphère, 2013, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2013LIL10102

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Les molécules organiques complexes sont abondantes dans le milieu interstellaire et leur détection est indispensable à la compréhension des processus chimiques gouvernant l'univers. Les détections… (more)

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Les molécules organiques complexes sont abondantes dans le milieu interstellaire et leur détection est indispensable à la compréhension des processus chimiques gouvernant l'univers. Les détections astronomiques sont réalisées par des télescopes comme ALMA, SOFIA, HERSCHEL et IRAM, dans le domaine millimétrique. À cette fin la spectroscopie de rotation en laboratoire est une étape indispensable. L'étude du glycolaldéhyde, de l'isocyanure d'allyle et du formiate de méthyle a été réalisée. Les spectres ont été enregistrés sur le spectromètre millimétrique et submillimétrique du PhLAM. Le glycolaldéhyde est une molécule pré-biotique possible, les états fondamentaux et les trois premiers modes de vibration des deux isotopologues 13C ont été modélisés par le modèle théorique du Hamiltonien de Watson. Le formiate de méthyle, isomère du glycolaldéhyde, est très abondant dans le milieu interstellaire. Il contient un groupe méthyle et est caractérisé par un mouvement de grande amplitude qui se couple avec la rotation globale de la molécule. La modélisation de ce couplage a nécessité un ajustement global des états de torsion νt = 0 et 1 du groupe méthyle de l'isotopologue 13C-2. Sa détection dans Orion-KL sera reportée. L'isocyanure d'allyle est d'intérêt astrophysique. Cette molécule présente une structure hyperfine due à l'atome N et résolue uniquement dans le domaine micro-onde. L'analyse des états fondamentaux des conformères Cis et Gauche les plus stables a été entendue dans le domaine millimétrique et submillimétrique. L'interaction de Coriolis (type a et b) entre les niveaux ν1 = 1 et ν2 = 1 du conformère Cis de l’isocyanure d’allyle a été modélisée.

Complex organic molecules are abundant in the interstellar medium and their detection play a big role in the comprehension of the chemical processes governing the evolution of the universe. Astronomical detection in the millimeter- wave region is realized by the use of telescopes such as ALMA, SOFIA, HERSCHEL and IRAM. For this purpose, rotational spectroscopy in the laboratory is an essential stage. In consequence, the study of glycolaldehyde, allylisocyanide and methylformate was elaborated. The spectrum of these molecules was recorded with the millimeter- and submillimeter- wave spectrometer in the PhLAM laboratory. Glycolaldehyde is a possible prebiotic molecule. The rotational spectra of the ground state and the three lowest vibrational modes for the two 13C isotopologs were modeled by a Watson Hamiltonian. The methylformate is an isomer of glycolaldehyde and is very abundant in the interstellar medium. It is characterized by the presence of methyl group establishing large amplitude motion witch couples with the global rotation of the molecule. To model this interaction for the 13C-2 isotopolog, a global fit of the two torsional states νt = 0 et 1 of the methyl group is required. The detection of νt = 1 in Orion-KL will be reported. Allylisocyanide is of astrophysical interest. This molecule establishes an hyperfine structure due to the presence of the N atom. This…

Advisors/Committee Members: Huet, Thérèse (thesis director), Margulès, Laurent (thesis director).

Subjects/Keywords: Molécules organiques complexes; 523.112 5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haykal, I. (2013). Spectroscopie millimétrique et submilimétrique de molécules astrophysiques : application au Formiate de Méthyle, au Glycolaldéhyde et à l’Isocyanure d’Allyle : Millimeter and submillimeter wave spectroscopy of astrophysical molecules : application to Methylformate, Glycolaldehyde and Allylisocyanide. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2013LIL10102

Chicago Manual of Style (16^th Edition):

Haykal, Imane. “Spectroscopie millimétrique et submilimétrique de molécules astrophysiques : application au Formiate de Méthyle, au Glycolaldéhyde et à l’Isocyanure d’Allyle : Millimeter and submillimeter wave spectroscopy of astrophysical molecules : application to Methylformate, Glycolaldehyde and Allylisocyanide.” 2013. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2013LIL10102.

MLA Handbook (7^th Edition):

Haykal, Imane. “Spectroscopie millimétrique et submilimétrique de molécules astrophysiques : application au Formiate de Méthyle, au Glycolaldéhyde et à l’Isocyanure d’Allyle : Millimeter and submillimeter wave spectroscopy of astrophysical molecules : application to Methylformate, Glycolaldehyde and Allylisocyanide.” 2013. Web. 04 Mar 2021.

Vancouver:

Haykal I. Spectroscopie millimétrique et submilimétrique de molécules astrophysiques : application au Formiate de Méthyle, au Glycolaldéhyde et à l’Isocyanure d’Allyle : Millimeter and submillimeter wave spectroscopy of astrophysical molecules : application to Methylformate, Glycolaldehyde and Allylisocyanide. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2013. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2013LIL10102.

Council of Science Editors:

Haykal I. Spectroscopie millimétrique et submilimétrique de molécules astrophysiques : application au Formiate de Méthyle, au Glycolaldéhyde et à l’Isocyanure d’Allyle : Millimeter and submillimeter wave spectroscopy of astrophysical molecules : application to Methylformate, Glycolaldehyde and Allylisocyanide. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2013. Available from: http://www.theses.fr/2013LIL10102

27. Michaux, Gwénaëlle. Fire retardancy of Polyamide 6 for electrotechnical applications : Ignifugation du polyamide 6 pour des applications électrotechniques.

Degree: Docteur es, Molécules et matière condensée, 2014, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2014LIL10200

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Cette étude s’intéresse aux procédés d’ignifugation d’un thermoplastique, le polyamide 6 (PA6), et plus particulièrement à l’ajout en masse d’un retardateur de flamme (RF) minéral… (more)

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Cette étude s’intéresse aux procédés d’ignifugation d’un thermoplastique, le polyamide 6 (PA6), et plus particulièrement à l’ajout en masse d’un retardateur de flamme (RF) minéral : le dihydroxyde de magnésium (MDH). L’objectif de ce projet consiste à remplacer le retardateur de flamme d’une formulation existante, constituée de PA6 renforcé fibres de verre (FV) et ignifugée à l’aide de cyanurate de mélamine, pour des raisons sanitaires et environnementales, en vue d’une application dans le domaine électrotechnique. Dans un premier temps, du MDH, avec ou sans traitement de surface, est étudié dans un mélange PA6 18%FV 40%RF et l’utilisation de la charge présentant un traitement de surface vinylsilane s’est avéré particulièrement efficace en terme d’amélioration du comportement au feu. Les mécanismes d’ignifugation furent étudiés et révèlent que le traitement de surface agit comme un comptabilisant et un agent dispersant, ce qui permet d’avoir une meilleure action en phase condensée. Comme de grandes quantités de MDH sont nécessaires pour obtenir de bonnes propriétés feu, ce qui altère les propriétés mécaniques, la diminution du taux de fibres de verre a été considérée dans un second temps. Il a été démontré que les fibres de verre participent à la formation de la phase condensée engendrée par la déshydratation du MDH en augmentant son efficacité. Dans un troisième temps, l’influence de l’ajout de dioxyde de titane, utilisé comme pigment blanchissant, fut étudié. Il a été suggéré que le TiO2 engendrait le clivage des chaines de PA6 durant la mise en œuvre et durant la combustion du matériau, mais que la mesure de cet effet dépend de la composition du mélange.

This study deals with the fireproofing of a thermoplastic, polyamide 6 (PA6), especially with the addition of a mass of flame retardant (FR) mineral: magnesium dihydroxide (MDH). The objective of this project is to replace the flame retardant of an existing formulation, consisting of polyamide 6 reinforced with glass fibers (GF) and fire retarded with melamine cyanurate, for electrotechnical applications. Initially, the MDH, with or without surface treatment, is studied in a mixture PA6 18% GF 40% FR and the use of the filler treated with vinylsilane was particularly effective in terms of fire performances. Fireproofing mechanisms were studied and show that the surface treatment acts as a compatibilizing agent and as a dispersing agent which allows a better action in the condensed phase. As large quantities of MDH are needed to obtain good fire properties, which alters the mechanical properties, the reduction of the glass fiber content was considered in a second time. It has been shown that glass fibers contribute to the formation of the condensed phase generated by the dehydration of MDH by increasing its effectiveness. Thirdly, the influence of the addition of titanium dioxide used as a whitening pigment was studied. It was suggested that TiO2 induced the cleavage of polyamide 6 chains during processing and during combustion of the material, but that the…

Advisors/Committee Members: Duquesne, Sophie (thesis director), Casetta, Mathilde (thesis director).

Subjects/Keywords: Dihydroxyde de magnésium; 668.423 5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Michaux, G. (2014). Fire retardancy of Polyamide 6 for electrotechnical applications : Ignifugation du polyamide 6 pour des applications électrotechniques. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2014LIL10200

Chicago Manual of Style (16^th Edition):

Michaux, Gwénaëlle. “Fire retardancy of Polyamide 6 for electrotechnical applications : Ignifugation du polyamide 6 pour des applications électrotechniques.” 2014. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2014LIL10200.

MLA Handbook (7^th Edition):

Michaux, Gwénaëlle. “Fire retardancy of Polyamide 6 for electrotechnical applications : Ignifugation du polyamide 6 pour des applications électrotechniques.” 2014. Web. 04 Mar 2021.

Vancouver:

Michaux G. Fire retardancy of Polyamide 6 for electrotechnical applications : Ignifugation du polyamide 6 pour des applications électrotechniques. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2014. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2014LIL10200.

Council of Science Editors:

Michaux G. Fire retardancy of Polyamide 6 for electrotechnical applications : Ignifugation du polyamide 6 pour des applications électrotechniques. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2014. Available from: http://www.theses.fr/2014LIL10200

McMaster University

28. Shamshoom, Christina. Pillar[5]arene Decorated Single-Walled Carbon Nanotubes.

Degree: MSc, 2019, McMaster University

URL: http://hdl.handle.net/11375/24087

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Control of single-walled carbon nanotube dispersion properties is of substantial interest to the scientific community. In this work, we sought to investigate the effect of… (more)

Subjects/Keywords: Carbon nanotubes; Pillar[5]arene

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shamshoom, C. (2019). Pillar[5]arene Decorated Single-Walled Carbon Nanotubes. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/24087

Chicago Manual of Style (16^th Edition):

Shamshoom, Christina. “Pillar[5]arene Decorated Single-Walled Carbon Nanotubes.” 2019. Masters Thesis, McMaster University. Accessed March 04, 2021. http://hdl.handle.net/11375/24087.

MLA Handbook (7^th Edition):

Shamshoom, Christina. “Pillar[5]arene Decorated Single-Walled Carbon Nanotubes.” 2019. Web. 04 Mar 2021.

Vancouver:

Shamshoom C. Pillar[5]arene Decorated Single-Walled Carbon Nanotubes. [Internet] [Masters thesis]. McMaster University; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11375/24087.

Council of Science Editors:

Shamshoom C. Pillar[5]arene Decorated Single-Walled Carbon Nanotubes. [Masters Thesis]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/24087

29. Derho, Joffrey. Élaboration et caractérisation de systèmes ternaires miscibles PLA/PEO/argile native : analyse des phénomènes de séparation de phases et d’interdiffusion : Preparation and characterization of PLA/PEO/pristine clay miscible ternary systems : analysis of phase segregation and interdiffusion phenomena.

Degree: Docteur es, Molécules et matière condensée, 2014, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2014LIL10196

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Ce travail de thèse porte sur l’élaboration et la caractérisation de systèmes ternaires miscibles PLA/PEO/argile native en vue de combiner la miscibilité PLA/PEO et l'affinité… (more)

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Ce travail de thèse porte sur l’élaboration et la caractérisation de systèmes ternaires miscibles PLA/PEO/argile native en vue de combiner la miscibilité PLA/PEO et l'affinité PEO-argile native. La démarche de préparation des systèmes ternaires consiste alors à disperser au préalable l’argile dans une matrice PEO. Tous les mélanges PEO/argile ainsi extrudés sont des nanocomposites intercalés. Avec l’augmentation du taux de charge au-delà de 10% en masse, la mobilité des chaines confinées est fortement contrainte et le comportement rhéologique du polymère est significativement modifié. Des interactions fortes PEO-feuillets et inter-feuillets sont ainsi révélées. Ensuite, la dilution en extrudeuse au sein du PLA de mélanges maîtres PEO/argile aboutit à des nanocomposites PLA/PEO/argile native intercalés. Les empilements PEO-feuillets contenus dans les mélanges maîtres sont en fait conservés dans les mélanges ternaires en raison des interactions fortes PEO-feuillets et inter-feuillets. En conséquence, les mécanismes de séparation de phase identifiés lors du vieillissement sont significativement ralentis comparativement aux mélanges binaires PLA/PEO. Enfin, des systèmes adhérents biphasiques sont produits par surmoulage. L'interdiffusion de bicouches à l'état fondu est aussi analysée quantitativement par rhéologie dynamique. En l’absence d’argile, l’adhérence de surmoulage est significative et une cinétique rapide d’interdiffusion du fondu PLA/PEO est mise en évidence. A l’opposé, lorsqu’une fraction d’argile élevée est dispersée au sein du PEO, un temps d’interdiffusion identique ne permet plus d’obtenir un fondu homogène et la dégradation thermique est accentuée.

This PhD work is about the preparation and characterization of PLA/PEO/pristine clay miscible ternary systems with the view to combine PLA/PEO miscibility and PEO-pristine clay affinity. The strategy for preparing the ternary systems then includes beforehand the dispersion of clay into the PEO matrix. All extruded PEO/pristine clay blends are intercalated nanocomposites. While increasing clay concentration above 10%, the mobility of confined chains is strongly constrained and the polymer rheological behavior is significantly modified. PEO-clay platelet and platelet-platelet interactions are hence highlighted. Then, the dilution of PEO/clay masterbatches into PLA by extrusion leads to PLA/PEO/pristine clay intercalated nanocomposites. Stacked PEO-platelet structures contained in masterbatches are in fact maintained in ternary blends due to the strong PEO-platelet and platelet-platelet interactions. Consequently the phase segregation mechanisms identified as part of the ageing are significantly slowed down compared to PLA/PEO binary blends. Eventually, biphasic adhesive systems are processed by over-injection molding. The interdiffusion of melted bilayers is also quantitatively analyzed by dynamic rheology. Without clay, the adhesion strength is significant and a rapid interdiffusion kinetics of PLA/PEO melt is revealed. On the other hand, when a high clay…

Advisors/Committee Members: Krawczak, Patricia (thesis director), Soulestin, Jérémie (thesis director).

Subjects/Keywords: Miscibilité; Surmoulage; 668.422 5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Derho, J. (2014). Élaboration et caractérisation de systèmes ternaires miscibles PLA/PEO/argile native : analyse des phénomènes de séparation de phases et d’interdiffusion : Preparation and characterization of PLA/PEO/pristine clay miscible ternary systems : analysis of phase segregation and interdiffusion phenomena. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2014LIL10196

Chicago Manual of Style (16^th Edition):

Derho, Joffrey. “Élaboration et caractérisation de systèmes ternaires miscibles PLA/PEO/argile native : analyse des phénomènes de séparation de phases et d’interdiffusion : Preparation and characterization of PLA/PEO/pristine clay miscible ternary systems : analysis of phase segregation and interdiffusion phenomena.” 2014. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed March 04, 2021. http://www.theses.fr/2014LIL10196.

MLA Handbook (7^th Edition):

Derho, Joffrey. “Élaboration et caractérisation de systèmes ternaires miscibles PLA/PEO/argile native : analyse des phénomènes de séparation de phases et d’interdiffusion : Preparation and characterization of PLA/PEO/pristine clay miscible ternary systems : analysis of phase segregation and interdiffusion phenomena.” 2014. Web. 04 Mar 2021.

Vancouver:

Derho J. Élaboration et caractérisation de systèmes ternaires miscibles PLA/PEO/argile native : analyse des phénomènes de séparation de phases et d’interdiffusion : Preparation and characterization of PLA/PEO/pristine clay miscible ternary systems : analysis of phase segregation and interdiffusion phenomena. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2014. [cited 2021 Mar 04]. Available from: http://www.theses.fr/2014LIL10196.

Council of Science Editors:

Derho J. Élaboration et caractérisation de systèmes ternaires miscibles PLA/PEO/argile native : analyse des phénomènes de séparation de phases et d’interdiffusion : Preparation and characterization of PLA/PEO/pristine clay miscible ternary systems : analysis of phase segregation and interdiffusion phenomena. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2014. Available from: http://www.theses.fr/2014LIL10196

University of Ottawa

30. Cardin, Valerie. The Role of the 5-HT1A Autoreceptor In Response to Antidepressant Treatment .

Degree: 2017, University of Ottawa

URL: http://hdl.handle.net/10393/36214

► Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatment for major depression, but require several weeks to elicit a clinical effect. One mechanism that may… (more)

▼ Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatment for major depression, but require several weeks to elicit a clinical effect. One mechanism that may underlie this delay in SSRI action implicates the gradual desensitization of 5-HT1A autoreceptors, leading to enhanced firing and increasing serotonin (5-HT) at the synapse. I hypothesized that in absence of 5-HT1A autoreceptors, fluoxetine (FLX) would improve behavior faster and more effectively. To specifically knock out 5-HT1A receptors in 5-HT neurons, we crossed TPH2-CREERT2 and flx5HT1A-YFP mice to generate the flx1A mice, a tamoxifen-inducible conditional knockout. Tamoxifen-induced recombination in adult flx1A-/- mice induced YFP expression and reduced 5-HT1A receptor levels by over 90%, specifically in TPH-positive cells of the raphe. To test the response to sub-chronic SSRI treatment, the mice were treated for 9 days with SSRIs FLX or escitalopram and examined for anxiety and depression-like behavior using multiple tests, including the novelty suppressed feeding test (NSF) that responds to chronic but not acute SSRI treatment. Subchronic FLX treatment had no effect in flx1A +/+ control mice, but resulted in an unexpected anxiogenic effect in flx1A -/- littermates, in both the NSF and elevated plus maze tests. Subchronic treatment with escitalopram also increased anxiety-like behavior in the NSF in flx1A-/-, but not wild-type mice. To determine whether FLX treatment differentially affected brain activity in these mice, the number of FosB-stained cells was determined as an index of chronic activation. In flx1A -/- vs. +/+ mice, the number of FosB-positive cells was reduced in several brain regions linked to anxiety and depression including hippocampus and entorhinal cortex, and FLX III treatment reduced activation in the flx1A +/+ compared to -/- mice these areas and in 5-HT neurons of the median raphe nucleus. These results suggest that in the absence of 5-HT1A autoreceptors, SSRIs have a pro-anxiety effect that may involve reduced inactivation anxiety-related brain regions.

Subjects/Keywords: Serotonin; 5-HT1A; Anxiety; Depression

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cardin, V. (2017). The Role of the 5-HT1A Autoreceptor In Response to Antidepressant Treatment . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/36214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cardin, Valerie. “The Role of the 5-HT1A Autoreceptor In Response to Antidepressant Treatment .” 2017. Thesis, University of Ottawa. Accessed March 04, 2021. http://hdl.handle.net/10393/36214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cardin, Valerie. “The Role of the 5-HT1A Autoreceptor In Response to Antidepressant Treatment .” 2017. Web. 04 Mar 2021.

Vancouver:

Cardin V. The Role of the 5-HT1A Autoreceptor In Response to Antidepressant Treatment . [Internet] [Thesis]. University of Ottawa; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10393/36214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cardin V. The Role of the 5-HT1A Autoreceptor In Response to Antidepressant Treatment . [Thesis]. University of Ottawa; 2017. Available from: http://hdl.handle.net/10393/36214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations