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1. Skrzypek, Klaudia. Role of microRNAs in non-small cell lung carcinoma : effect of heme oxygenase-1 : Rôle des microARNs dans le carcinome pulmonaire non à petites cellules : effet de l’hème oxygénase-1.

Degree: Docteur es, Biologie cellulaire et moléculaire, 2013, Orléans; Uniwersytet Jagielloński (Cracovie, Pologne)

L’hème oxygénase-1 (HO-1), enzyme antioxydante, est capable de prévenir l’initiation tumorale tandis qu’elle promeut la progression de certaines tumeurs et l’angiogenèse. Ce travail a recherché si HO-1 peut moduler les microARNs et régule le développmemnt du carcinome pulmonaire humain non à petites cellules (NSCLC). La surexpression stable de HO-1 dans les cellules du NSCLC NCI-H292 accroit la production globale des miARNs et diminue significativement l’expression des oncomirs et angiomirs, tandis qu’elle augmente les miARNs suppresseurs de tumeurs. Le plus amplement diminué est le miR-378. Dans les cellules surexprimant HO-1 la p53 est aussi augmentée, Ang-1 et MUC5AC diminuées, prolifération migration et potentiel angiogéniques réduits. Les effets de HO-1 sur la prolifération tumorale, la migration et et l’expression de miR-378 sont modulées par CO. Au contraire, la surexpression stable de miR-378 décroit celle de HO-1 et de p53 tandis qu’elle accroît celle de MUC5AC, VEGF, IL-8 et Ang-1 et en conséquence accroit la prolifération, migration la stimulation des cellules endothéliales. L’ajout de HO-1 à des cellules surexprimant miR-378 réverse l’effet de miR-378 sur la prolifération et la migration des cellules cancéreuses. In vivo, les tumeurs surexprimant HO-1 sont de taille réduite, moins vascularisées et oxygénées et moins métastatiques tandis que la surexpression de miR-378 produit les effets inverses. Conformément, chez les patients NSCLC, l’expression de HO-1est réduite dans les métastases lymphatiques par rapport à la tumeur primaire tandis que miR-378 n’est pas modifié de manière significative. En conclusion, les résultats in vitro et in vivo indiquent que l’action coordonnée entre HO-1 et miR-378 module de manière significative la progression et l’angiogenèse du carcinome humain pulmonaire non à petites cellules.

Heme oxygenase-1 (HO-1), an antioxidant enzyme can prevent tumor initiation while it has been demonstrated to promote various tumors progression and angiogenesis. Here it was investigated whether HO-1 can modulate microRNAs and regulate human non-small cell lung cancer (NSCLC) development. Stable HO-1 overexpression in NSCLC NCI-H292 cells enhanced global production of miRNAs and significantly diminished expression of oncomirs and angiomirs, whereas upregulated tumor suppressive miRNAs. The most potently downregulated was miR-378. HO-1 overexpressing cells displayed also upregulated p53, downregulated Ang-1 and MUC5AC, reduced proliferation, migration and diminished angiogenic potential. CO was a mediator of HO-1 effects on tumor cells proliferation, migration and miR-378 expression. In contrast, stable miR-378 overexpression decreased HO-1 and p53 while enhanced expression of MUC5AC, VEGF, IL-8 and Ang-1 and consequently increased proliferation, migration and stimulation of endothelial cells. Adenoviral delivery of HO-1 to miR-378 overexpressing cells reversed miR-378 effect on proliferation and migration of cancer cells. In vivo, HO-1 overexpressing tumors were smaller, less vascularized and…

Advisors/Committee Members: Kiéda, Claudine (thesis director), Dulak, Jozef (thesis director).

Subjects/Keywords: Carcinome humain pulmonaire non à petites cellules (NSCLC); Cancer du poumon; MicroARN; MiR-378; Hème oxygénase-1 (HO-1); Angiogenèse; Non-small cell lung carcinoma (NSCLC); Lung cancer; MicroRNA; MiR-378; Heme oxygenase-1 (HO-1); Angiogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Skrzypek, K. (2013). Role of microRNAs in non-small cell lung carcinoma : effect of heme oxygenase-1 : Rôle des microARNs dans le carcinome pulmonaire non à petites cellules : effet de l’hème oxygénase-1. (Doctoral Dissertation). Orléans; Uniwersytet Jagielloński (Cracovie, Pologne). Retrieved from http://www.theses.fr/2013ORLE2001

Chicago Manual of Style (16th Edition):

Skrzypek, Klaudia. “Role of microRNAs in non-small cell lung carcinoma : effect of heme oxygenase-1 : Rôle des microARNs dans le carcinome pulmonaire non à petites cellules : effet de l’hème oxygénase-1.” 2013. Doctoral Dissertation, Orléans; Uniwersytet Jagielloński (Cracovie, Pologne). Accessed March 20, 2019. http://www.theses.fr/2013ORLE2001.

MLA Handbook (7th Edition):

Skrzypek, Klaudia. “Role of microRNAs in non-small cell lung carcinoma : effect of heme oxygenase-1 : Rôle des microARNs dans le carcinome pulmonaire non à petites cellules : effet de l’hème oxygénase-1.” 2013. Web. 20 Mar 2019.

Vancouver:

Skrzypek K. Role of microRNAs in non-small cell lung carcinoma : effect of heme oxygenase-1 : Rôle des microARNs dans le carcinome pulmonaire non à petites cellules : effet de l’hème oxygénase-1. [Internet] [Doctoral dissertation]. Orléans; Uniwersytet Jagielloński (Cracovie, Pologne); 2013. [cited 2019 Mar 20]. Available from: http://www.theses.fr/2013ORLE2001.

Council of Science Editors:

Skrzypek K. Role of microRNAs in non-small cell lung carcinoma : effect of heme oxygenase-1 : Rôle des microARNs dans le carcinome pulmonaire non à petites cellules : effet de l’hème oxygénase-1. [Doctoral Dissertation]. Orléans; Uniwersytet Jagielloński (Cracovie, Pologne); 2013. Available from: http://www.theses.fr/2013ORLE2001


Universitat Ramon Llull

2. Mosteo Chagoyen, Leticia Pilar. Executive coaching: an exploration of the what, how and who of coaching practices from a cognitive-emotional and cross-cultural perspective.

Degree: 2015, Universitat Ramon Llull

The intellectual integrity of coaching depends on rigorous research. Executive coaching has gained significant momentum as a resource for workforce development in corporate and non-profit organizations despite still scarce empirical evidence on its impact and its key factors, and wide disagreement about necessary or desired professional qualifications. This doctoral thesis examines the practice of executive coaching from three core differentiate yet complementary dimensions of the coaching cube (what, how, who). The significance of the overall research lies in its integration of the extant literature on executive coaching and the comprehensive exploration of coaching from those three key angles using a mixed-methods approach, in order to gain a better grasp of the coaching process and its potential impact from its core elements. As a necessary first step, the first study provides a conceptual framework of coaching value perception from the executives’ standpoint (beyond coaching agendas; the what) with the objective of tapping into one of the main problems of measuring coaching impact: the perception of value from its direct recipient. In this regard, moderators on the perceived value of coaching are presented. The second study shares a rigorous analysis on the impact of coaching under a lifelong learning umbrella (Intentional Change Theory) (the how), aiming to better understand the emotional-cognitive processing behind on its executive recipients as well as key moderators on the coaching outcomes grasped. The third study goes a step further on coaches characteristics (coaching competencies; the who) and suggests evidence-based insights for the clarity and inclusion of intercultural competence, once identified certain cultural biases embedded in an existing worldwide used coaching competency model (ICF’s). The overall investigation aims to make a novel contribution by explicitly focusing on the particular elements that build the emotional-social (and thus, cultural-) interaction between coach-coachee, which constitutes an essential aspect of all coaching types and methodologies and that we refer to as the quality of the connection evolved. The quality of the present research is critically discussed, future research lines recommended as well as the theoretical and practical implications of the present studies reviewed. Advisors/Committee Members: ESADE ADE - Direcció General i Estratègia i de Direcció de Persones i Organització, [email protected] (authoremail), true (authoremailshow), Batista Foguet, Joan Manuel (director), true (authorsendemail).

Subjects/Keywords: Executive Coaching Value Perception; Quality of Coaching Relationship; Executive Coaching Competencies; Coach's Characteristics; Coachee's Characteristics; Emotional Attractors; Intentional Change Theory; Ideal Self; Cultural Competence; Coach Education and Training; Ciències Socials i Jurídiques; 00; 1; 159.9; 3; 378

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mosteo Chagoyen, L. P. (2015). Executive coaching: an exploration of the what, how and who of coaching practices from a cognitive-emotional and cross-cultural perspective. (Thesis). Universitat Ramon Llull. Retrieved from http://hdl.handle.net/10803/347963

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mosteo Chagoyen, Leticia Pilar. “Executive coaching: an exploration of the what, how and who of coaching practices from a cognitive-emotional and cross-cultural perspective.” 2015. Thesis, Universitat Ramon Llull. Accessed March 20, 2019. http://hdl.handle.net/10803/347963.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mosteo Chagoyen, Leticia Pilar. “Executive coaching: an exploration of the what, how and who of coaching practices from a cognitive-emotional and cross-cultural perspective.” 2015. Web. 20 Mar 2019.

Vancouver:

Mosteo Chagoyen LP. Executive coaching: an exploration of the what, how and who of coaching practices from a cognitive-emotional and cross-cultural perspective. [Internet] [Thesis]. Universitat Ramon Llull; 2015. [cited 2019 Mar 20]. Available from: http://hdl.handle.net/10803/347963.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mosteo Chagoyen LP. Executive coaching: an exploration of the what, how and who of coaching practices from a cognitive-emotional and cross-cultural perspective. [Thesis]. Universitat Ramon Llull; 2015. Available from: http://hdl.handle.net/10803/347963

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.