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Louisiana State University
1.
Forney, Laura Ann.
The Anti-Inflammatory Effects of Vitamin D and Exercise.
Degree: PhD, Kinesiology, 2014, Louisiana State University
URL: etd-11072014-130925
;
https://digitalcommons.lsu.edu/gradschool_dissertations/3667 
► Elevated inflammation is associated with several chronic diseases, including obesity. Exercise is an established effective treatment of this condition by decreasing adiposity and independently regulating…
(more)
▼ Elevated inflammation is associated with several chronic diseases, including obesity. Exercise is an established effective treatment of this condition by decreasing adiposity and independently regulating inflammatory pathways. The potential for vitamin D to confer anti-inflammatory benefits has been explored in cell culture studies, but few have explored its action at the whole body level. PURPOSE: To investigate the relationship between inflammatory markers in trained and untrained individuals with vitamin D levels either above or below a suggested optimal concentration. METHODS: College-aged females (N = 63), both trained and untrained, reported to the lab four times: to assess body size and composition, for blood collection, for a maximal aerobic test, and a test of anaerobic power. Blood was analyzed for serum 25OHD and CRP concentrations, stimulated with LPS to assess IL-6 production. Samples were prepared for FACS analysis for CD14, CD16, and TLR4 expression. RESULTS: Trained individuals presented with higher 25OHD levels, even prior to stratification into high and low groups (p = 0.015). VO2peak was significantly higher (p < 0.0001) and fatigue during the test for anaerobic power was significantly lower (p = 0.021) in trained individuals. Untrained individuals had a higher average body weight (p = 0.039) and estimated percent body fat (p = 0.011) compared to trained individuals, although the average estimated percent body fat of both groups was higher than the recommended level for this age group. Additionally, measures of sun exposure were negatively correlated with measures of body size and composition, although these relationships did not exist between serum 25OHD. CONCLUSION: In this study, regular physical activity was associated with higher serum 25OHD, lower BMI, waist circumference, and estimated percent body fat as well as reduced LPS-stimulated IL-6 production. Optimal vitamin D status did not appear to provide any additional health related or anti-inflammatory benefit in those with regular physical activity habits. However, in individuals not participating in a regular exercise program, the potential for vitamin D to mediate inflammation appeared more likely. More specifically, untrained people with optimal vitamin D status had lower numbers of total monocytes, CD14+CD16- cells, and decreased TLR4 expression on CD14+CD16+ cells; however, these differences did not translate into a change in overall cell function or markers of systemic inflammation as there was no difference between optimal and suboptimal groups with respect to LPS-stimulated IL-6 production or resting CRP concentrations. An expanded exploration of the relationship between vitamin D and inflammation may include assessing other inflammatory biomarkers, immune cell types, the vitamin D receptor, and the role of adipose tissue.
Subjects/Keywords: 25-hydroxyvitamin D; interleukin-6; physical activity
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APA (6th Edition):
Forney, L. A. (2014). The Anti-Inflammatory Effects of Vitamin D and Exercise. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-11072014-130925 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3667
Chicago Manual of Style (16th Edition):
Forney, Laura Ann. “The Anti-Inflammatory Effects of Vitamin D and Exercise.” 2014. Doctoral Dissertation, Louisiana State University. Accessed March 06, 2021.
etd-11072014-130925 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3667.
MLA Handbook (7th Edition):
Forney, Laura Ann. “The Anti-Inflammatory Effects of Vitamin D and Exercise.” 2014. Web. 06 Mar 2021.
Vancouver:
Forney LA. The Anti-Inflammatory Effects of Vitamin D and Exercise. [Internet] [Doctoral dissertation]. Louisiana State University; 2014. [cited 2021 Mar 06].
Available from: etd-11072014-130925 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3667.
Council of Science Editors:
Forney LA. The Anti-Inflammatory Effects of Vitamin D and Exercise. [Doctoral Dissertation]. Louisiana State University; 2014. Available from: etd-11072014-130925 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3667
Louisiana State University
2.
Forney, Laura.
Vitamin D status, adiposity, and athletic performance measures in college-aged students.
Degree: MS, Kinesiology, 2012, Louisiana State University
URL: etd-06222012-175202
;
https://digitalcommons.lsu.edu/gradschool_theses/1503
► Research suggests that elevated serum concentrations of 25-hydroxyvitamin D (25OHD) are associated with slowing the development of many age-related chronic diseases. Recent reports also show…
(more)
▼ Research suggests that elevated serum concentrations of 25-hydroxyvitamin D (25OHD) are associated with slowing the development of many age-related chronic diseases. Recent reports also show a positive relationship between 25OHD and muscle synthesis, strength, power and decreased body fat in elderly individuals. However, these findings have not been consistently reported in younger, healthy populations. PURPOSE: To investigate the relationship between 25OHD levels, body composition, measures of aerobic fitness and muscular strength and power in a young, physically active population. METHODS: Thirty-nine active subjects (20 males, 19 females; 23 ± 0.7 years old) reported to the lab six times for testing. Blood was drawn and 25OHD concentrations were determined using an enzyme-linked immunosorbent assay (ELISA). Primary outcomes included: body composition (dual-energy x-ray absorptiometry, DXA); resting metabolic rate; maximal oxygen uptake (VO2max); power output (Wingate); and strength (eight repetition maximum of bench press, upright row and leg extension and flexion). Primary analysis included all participants, and sub-group analyses on those individuals considered to have sub-optimal serum 25OHD (< 35 ng/mL); LOW (n = 20, 25.97 ± 1.97 ng/mL) and adequate levels of 25OHD (< 35 ng/mL) HIGH (n =19, 44.15 ± 2.17 ng/mL). RESULTS: Half of the subjects (n = 20) exhibited less than optimal 25OHD status, due in part to lack of dietary intake. HIGH males had significantly higher VO2max values when compared to LOW males (p < 0.01). CONCLUSION: A high percentage of college-aged male and female individuals may not be consuming enough vitamin D and aerobic fitness may also be linked to vitamin D status.
Subjects/Keywords: body fat; 25-hydroxyvitamin D; aerobic fitness
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APA (6th Edition):
Forney, L. (2012). Vitamin D status, adiposity, and athletic performance measures in college-aged students. (Masters Thesis). Louisiana State University. Retrieved from etd-06222012-175202 ; https://digitalcommons.lsu.edu/gradschool_theses/1503
Chicago Manual of Style (16th Edition):
Forney, Laura. “Vitamin D status, adiposity, and athletic performance measures in college-aged students.” 2012. Masters Thesis, Louisiana State University. Accessed March 06, 2021.
etd-06222012-175202 ; https://digitalcommons.lsu.edu/gradschool_theses/1503.
MLA Handbook (7th Edition):
Forney, Laura. “Vitamin D status, adiposity, and athletic performance measures in college-aged students.” 2012. Web. 06 Mar 2021.
Vancouver:
Forney L. Vitamin D status, adiposity, and athletic performance measures in college-aged students. [Internet] [Masters thesis]. Louisiana State University; 2012. [cited 2021 Mar 06].
Available from: etd-06222012-175202 ; https://digitalcommons.lsu.edu/gradschool_theses/1503.
Council of Science Editors:
Forney L. Vitamin D status, adiposity, and athletic performance measures in college-aged students. [Masters Thesis]. Louisiana State University; 2012. Available from: etd-06222012-175202 ; https://digitalcommons.lsu.edu/gradschool_theses/1503
University of Alberta
3.
Singla, Sandeep.
Bone and meat discolouration of broiler chicken
thighs.
Degree: MS, Department of Agricultural, Food and Nutritional
Science, 2011, University of Alberta
URL: https://era.library.ualberta.ca/files/9880vs496
► Consumer acceptance of meat depends on its colour and there is a negative bias in North America for broiler dark meat. Freezing and cooking leads…
(more)
▼ Consumer acceptance of meat depends on its colour and
there is a negative bias in North America for broiler dark meat.
Freezing and cooking leads to changes in meat characteristics and
colour of broiler chicken thighs. The first experiment focused on
the effect of freezing and cooking on broiler thighs and
comparisons with fresh uncooked thighs. Freezing and cooking
resulted in pigment leakage from bones and meat heme pigment
oxidation and denaturation. The meat colour was not dark under the
applied conditions. The second experiment dealt with the effect of
diet (vitamin D, 25-hydroxyvitamin D3, dilute) fed to broilers
(Male Ross 308) on the meat characteristics and colour differences
in broiler thighs. The study revealed that bones from birds fed
25-hydroxyvitamin D3 diet may have a better bone mineralization
indicated by certain meat parameters. However the color of meat was
not affected by the dietary treatments.
Subjects/Keywords: discolouration; vitamin D; bone; meat; broiler; darkening; thigh; 25-hydroxyvitamin D
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APA (6th Edition):
Singla, S. (2011). Bone and meat discolouration of broiler chicken
thighs. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/9880vs496
Chicago Manual of Style (16th Edition):
Singla, Sandeep. “Bone and meat discolouration of broiler chicken
thighs.” 2011. Masters Thesis, University of Alberta. Accessed March 06, 2021.
https://era.library.ualberta.ca/files/9880vs496.
MLA Handbook (7th Edition):
Singla, Sandeep. “Bone and meat discolouration of broiler chicken
thighs.” 2011. Web. 06 Mar 2021.
Vancouver:
Singla S. Bone and meat discolouration of broiler chicken
thighs. [Internet] [Masters thesis]. University of Alberta; 2011. [cited 2021 Mar 06].
Available from: https://era.library.ualberta.ca/files/9880vs496.
Council of Science Editors:
Singla S. Bone and meat discolouration of broiler chicken
thighs. [Masters Thesis]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/9880vs496
Iowa State University
4.
Reynolds, Carmen J.
Vitamin D metabolites and their intestinal responses.
Degree: 2019, Iowa State University
URL: https://lib.dr.iastate.edu/etd/17086
► min D metabolites regulate calcium absorption in the intestines through activation of the vitamin D receptor (VDR) and resulting in increased expression of calcium-associated proteins.…
(more)
▼ min D metabolites regulate calcium absorption in the intestines through activation of the vitamin D receptor (VDR) and resulting in increased expression of calcium-associated proteins. Presently, it is thought that vitamin D metabolizes into a hormonal form, 1,25-dihydroxyvitamin D (1,25D), and the hormone then circulates via blood to the duodenum to stimulate calcium absorption. Recently, Koszewski et al. proposed that delivery of the hormone occurs via digestive passage rather than by the blood (Koszewski et al., 2012). Growing evidence has suggested, instead, that the hormonal precursor, 25-hydroxyvitamin D (25D), may have functional activity by either providing substrate for local hormonal production or by agonistically stimulating a response. In addition, the liver is recognized to produce and excrete both 25D and the glucuronide form, 25D-Gluc, in bile. The hypothesis guiding the present dissertation is that both 25D and 25D-Gluc may have hormonal effects in the intestine when delivered by way of digesta.
The following dissertation investigates the delivery and mechanism driving intestinal responses by these metabolites. Acute dosing of vitamin D metabolites, 25D and 1,25D, as well as their respective glucuronide conjugated derivatives, in vitamin D-normal mice was used to assess intestinal responses in vivo. Assays performed in cell culture were used to examine mechanisms of action. Responses to the metabolites both in vivo and in vitro were evaluated by measuring Cyp24 mRNA, an early and robust indicator of the VDR-mediated response. These assessments of Cyp24 were analyzed quantitatively by PCR and qualitatively by RNAscope, a recently developed RNA in situ hybridization technique. Results from these studies suggest that the vitamin D-mediated response is limited to intestinal epithelial cells nearest the luminal interior in both the duodenum and colon. Orally administered 25D was shown to elicit a response in the duodenum through agonistic binding and activity. Lastly, both oral and subcutaneous 25D-Gluc exhibited hormonal actions in the colon, but not the duodenum. The overall conclusion drawn from this dissertation is that 25D and its glucuronide conjugate are meaningful participants in regulating the VDR-mediated response in the intestines.
Subjects/Keywords: 25-Hydroxyvitamin D; Vitamin D; Biochemistry; Human and Clinical Nutrition; Nutrition
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APA (6th Edition):
Reynolds, C. J. (2019). Vitamin D metabolites and their intestinal responses. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/17086
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Reynolds, Carmen J. “Vitamin D metabolites and their intestinal responses.” 2019. Thesis, Iowa State University. Accessed March 06, 2021.
https://lib.dr.iastate.edu/etd/17086.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Reynolds, Carmen J. “Vitamin D metabolites and their intestinal responses.” 2019. Web. 06 Mar 2021.
Vancouver:
Reynolds CJ. Vitamin D metabolites and their intestinal responses. [Internet] [Thesis]. Iowa State University; 2019. [cited 2021 Mar 06].
Available from: https://lib.dr.iastate.edu/etd/17086.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Reynolds CJ. Vitamin D metabolites and their intestinal responses. [Thesis]. Iowa State University; 2019. Available from: https://lib.dr.iastate.edu/etd/17086
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Minnesota
5.
Kunisaki, Ken.
Vitamin D status and longitudinal lung function decline in the Lung Health Study.
Degree: MS, Clinical Research, 2014, University of Minnesota
URL: http://hdl.handle.net/11299/162843
► Low vitamin D blood levels are postulated to be a risk factor for worse lung function, largely based on cross-sectional data. We sought to use…
(more)
▼ Low vitamin D blood levels are postulated to be a risk factor for worse lung function, largely based on cross-sectional data. We sought to use longitudinal data to test the hypothesis that baseline plasma 25-hydroxyvitamin D [25(OH)D] is lower in subjects with more rapid lung function decline, compared to those with slow lung function decline. We conducted a nested, matched case-control study in the Lung Health Study 3 cohort. Cases and controls were continuous smokers with rapid and slow lung function decline, respectively, over approximately 6 years of follow-up. We compared baseline 25(OH)D levels between cases and controls, matching on date of blood draw and clinical center. Among 196 subjects, despite rapid and slow decliners experiencing strikingly and significantly different rates of decline of forced expiratory volume in one second (-152 vs. -0.3 mL/year; p<0.001), there was no significant difference in baseline 25(OH)D levels (25.0 vs. 25.9 ng/mL; p=0.54). There was a high prevalence of vitamin D insufficiency (35%) and deficiency (31%); only 4% had a normal 25(OH)D level in the winter. Although vitamin D insufficiency and deficiency are common among continuous smokers with established mild to moderate COPD, baseline 25(OH)D levels are not predictive of subsequent lung function decline.
Subjects/Keywords: 25-hydroxyvitamin D; COPD; FEV1; FVC; Lung function; Vitamin D
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APA (6th Edition):
Kunisaki, K. (2014). Vitamin D status and longitudinal lung function decline in the Lung Health Study. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/162843
Chicago Manual of Style (16th Edition):
Kunisaki, Ken. “Vitamin D status and longitudinal lung function decline in the Lung Health Study.” 2014. Masters Thesis, University of Minnesota. Accessed March 06, 2021.
http://hdl.handle.net/11299/162843.
MLA Handbook (7th Edition):
Kunisaki, Ken. “Vitamin D status and longitudinal lung function decline in the Lung Health Study.” 2014. Web. 06 Mar 2021.
Vancouver:
Kunisaki K. Vitamin D status and longitudinal lung function decline in the Lung Health Study. [Internet] [Masters thesis]. University of Minnesota; 2014. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/11299/162843.
Council of Science Editors:
Kunisaki K. Vitamin D status and longitudinal lung function decline in the Lung Health Study. [Masters Thesis]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/162843
University of Minnesota
6.
Fitzgerald, John.
Vitamin D Deficiency and Physical Performance in Athletes.
Degree: PhD, Kinesiology, 2013, University of Minnesota
URL: http://hdl.handle.net/11299/174851
► The aim of this cross-sectional study was to investigate the relationship between vitamin D status and laboratory measures that are relevant to physical performance in…
(more)
▼ The aim of this cross-sectional study was to investigate the relationship between vitamin D status and laboratory measures that are relevant to physical performance in competitive ice hockey players. Data was collected for 53 junior and collegiate ice hockey players residing near Minneapolis, Minnesota (44.9� N) during the offseason (May 16-June 28). Vitamin D status was inversely associated with percent body fat and positively associated with handgrip strength, trended with peak power during the wingate test, but not with vertical jump height after adjusting for measured covariates. Representing a novel finding of this study, 25(OH)D status was inversely related to jump execution time, time to peak power and positively associated with force gradient during the squat jump after adjusting for potential covariates.
Subjects/Keywords: 25-hydroxyvitamin D; adiposity; athletes; power; strength; vitamin D
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APA (6th Edition):
Fitzgerald, J. (2013). Vitamin D Deficiency and Physical Performance in Athletes. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/174851
Chicago Manual of Style (16th Edition):
Fitzgerald, John. “Vitamin D Deficiency and Physical Performance in Athletes.” 2013. Doctoral Dissertation, University of Minnesota. Accessed March 06, 2021.
http://hdl.handle.net/11299/174851.
MLA Handbook (7th Edition):
Fitzgerald, John. “Vitamin D Deficiency and Physical Performance in Athletes.” 2013. Web. 06 Mar 2021.
Vancouver:
Fitzgerald J. Vitamin D Deficiency and Physical Performance in Athletes. [Internet] [Doctoral dissertation]. University of Minnesota; 2013. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/11299/174851.
Council of Science Editors:
Fitzgerald J. Vitamin D Deficiency and Physical Performance in Athletes. [Doctoral Dissertation]. University of Minnesota; 2013. Available from: http://hdl.handle.net/11299/174851
7.
Pinheiro, Tânia Marisa Macedo.
A importância clínica da vitamina D.
Degree: 2015, Universidade Fernando Pessoa
URL: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5301
► Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
Nos últimos anos, o…
(more)
▼ Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
Nos últimos anos, o papel fisiológico da vitamina D tem sido amplamente estudado. A
sua ação primordial no metabolismo do cálcio é já bem conhecida, sendo esta uma das
hormonas responsáveis pela manutenção dos níveis de cálcio sérico, através da promoção
da absorção de cálcio e fósforo a partir do intestino e da reabsorção óssea de cálcio. No
entanto, o interesse clínico na vitamina D não se restringe apenas ao metabolismo
fosfocálcio, mas também se manifesta em várias outras condições médicas (diabetes,
doenças cardiovasculares, esclerose múltipla, câncer, distúrbios psiquiátricos, doenças
neuro-muscular). De facto, evidências recentes correlacionam níveis insuficientes de
vitamina D, com um risco aumentado de desenvolvimento de outras doenças, não
relacionadas com a componente óssea.
A elevada prevalência de níveis inadequados de vitamina D é hoje em dia encarada como
um problema de saúde pública que afeta vários países da Europa e os EUA. Por este
motivo, e pelo conhecimento do crescente número de doenças associadas a esta
deficiência, a medição exata dos níveis de vitamina D tem assumido elevada relevância
na clínica. Desta forma, o número de análises para avaliação da quantidade de vitamina
D para fins de diagnóstico aumentou significativamente. A concentração de 25-
hidroxivitamina D (25(OH)D) é o parâmetro de rotina, mas a determinação de outros
metabolitos, em particular a forma fisiologicamente ativa 1,25 dihidroxivitamina D
(1,25(OH)2D) pode ser também de interesse clínico. No entanto, os níveis séricos de
25(OH)D são o melhor indicador do conteúdo corporal de vitamina D, uma vez que reflete
a quantidade obtida a partir da ingestão e exposição à luz solar, assim como da conversão
de vitamina D a partir de depósitos de gordura no fígado. As últimas orientações da
Endocrine Society sugerem o rastreio do défice de vitamina D apenas em indivíduos em
risco e não na população em geral. Nestes doentes, recomenda-se a medição da 25(OH)D
sérica circulante, por um método analítico fiável.
Ao longo dos anos, técnicas de quantificação de 25(OH)D e a 1,25(OH)D têm aumentado
e evoluído. Estes métodos são baseados em ensaios de ligação competitiva por meio de
imunoensaio e cromatografia líquida associados com espectrometria de massa, no entanto
estes têm demonstrado vários desafios analíticos, sendo que as vantagens e desvantagens
de cada método mudam constantemente com novos desenvolvimentos tecnológicos. Os
imunoensaios continuam a ser o modo predominante de medição para 25(OH)D, embora os problemas com a recuperação equimolar dos metabolitos D2 e D3 permanecem um
problema.
O défice de vitamina D é definido por um valor de 25(OH)D inferior a 20 ng/mL (50
nmol/L). Em indivíduos em risco recomenda-se a ingestão de vitamina D na dieta, de
acordo com a idade e situações especiais (gravidez, amamentação, obesidade e toma
concomitante de alguns fármacos). Para o…
Advisors/Committee Members: Souto, Renata, Pimenta, Adriana.
Subjects/Keywords: Vitamina D; 25-hidroxivitamina D; 1,25-dihidroxivitamina D; Avaliação laboratorial; Vitamin D; 25-hydroxyvitamin D; 1,25 dihyroxy vitamin D; Laboratory assessment
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APA ·
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Manager
APA (6th Edition):
Pinheiro, T. M. M. (2015). A importância clínica da vitamina D. (Thesis). Universidade Fernando Pessoa. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5301
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pinheiro, Tânia Marisa Macedo. “A importância clínica da vitamina D.” 2015. Thesis, Universidade Fernando Pessoa. Accessed March 06, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5301.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pinheiro, Tânia Marisa Macedo. “A importância clínica da vitamina D.” 2015. Web. 06 Mar 2021.
Vancouver:
Pinheiro TMM. A importância clínica da vitamina D. [Internet] [Thesis]. Universidade Fernando Pessoa; 2015. [cited 2021 Mar 06].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5301.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pinheiro TMM. A importância clínica da vitamina D. [Thesis]. Universidade Fernando Pessoa; 2015. Available from: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5301
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Kansas
8.
Chan, Ka Ian.
Maternal Vitamin D Status Related to Triacylglycerol in Early Pregnancy and Subsequent Risk for Adverse Pregnancy Outcomes.
Degree: MS, Dietetics & Nutrition, 2011, University of Kansas
URL: http://hdl.handle.net/1808/7937
► Research has suggested roles of vitamin D in health beyond its action on calcium homeostasis and bone health. Recent studies revealed a high proportion of…
(more)
▼ Research has suggested roles of vitamin
D in health beyond its action on calcium homeostasis and bone health. Recent studies revealed a high proportion of pregnant women having low vitamin
D status. This may lead to increased risks for preeclampsia, gestational diabetes (GDM), and cesarean delivery. Findings on the effects of vitamin
D on these adverse pregnancy outcomes have been inconsistent. To our knowledge, no studies have examined maternal vitamin
D status with circulating triacylglycerol (TAG) concentrations. This study was conducted to assess the effects of maternal vitamin
D status on subsequent risk for pregnancy complications and to determine the effectiveness of
25-
hydroxyvitamin D [
25(OH)
D] to TAG ratio to indicate vitamin
D status. We measured the plasma
25(OH)
D and TAG concentrations of 299 pregnant women in their 8th to 20th week of gestation, and examined the association between
25(OH)
D concentrations,
25(OH)
D/TAG ratios and the risk of preeclampsia, GDM, and cesarean delivery. Of the 299 subjects, five developed preeclampsia, 15 developed GDM, and 89 delivered their infants by cesarean section. Women diagnosed with preeclampsia or GDM had significantly lower
25(OH)
D/TAG ratios than women without these complications. Women with
25(OH)
D concentrations and
25(OH)
D/TAG below medians had increased odds of preeclampsia (OR, 4.05; 95% CI, 0.45-36.71 and OR, 4.05; 95% CI, 0.45-36.71 respectively) and GDM (OR, 2.12; 95% CI, 0.71-6.38 and OR, 2.96, 95% CI, 0.92-9.55 respectively). These results were not statistically significant because of the small number of affected women, but the association between
25(OH)
D/TAG and GDM risk was close to significant (P = 0.07). Women with
25(OH)
D concentrations and
25(OH)
D/TAG below medians also had reduced odds for cesarean delivery (OR, 0.54; 95% CI, 0.32-0.89 and OR, 0.74; 95% CI, 0.45-1.22 respectively), but only the association between
25(OH)
D concentration and risk of cesarean delivery was statistically significant. This study suggested increased preeclampsia and GDM risks in women with low vitamin
D status. Few cases of these events compromised the statistical significance of results. The increased risk of cesarean delivery in women with higher vitamin
D status shown has to be reevaluated because reasons for cesarean delivery were not included in the analysis.
Advisors/Committee Members: Carlson, Susan E (advisor), Griffith, Linda D (cmtemember), Garimella, Rama (cmtemember).
Subjects/Keywords: Nutrition; 25-hydroxyvitamin d; Cesarean delivery; Gestational diabetes; Preeclampsia; Pregnancy; Triacylglycerol
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APA (6th Edition):
Chan, K. I. (2011). Maternal Vitamin D Status Related to Triacylglycerol in Early Pregnancy and Subsequent Risk for Adverse Pregnancy Outcomes. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/7937
Chicago Manual of Style (16th Edition):
Chan, Ka Ian. “Maternal Vitamin D Status Related to Triacylglycerol in Early Pregnancy and Subsequent Risk for Adverse Pregnancy Outcomes.” 2011. Masters Thesis, University of Kansas. Accessed March 06, 2021.
http://hdl.handle.net/1808/7937.
MLA Handbook (7th Edition):
Chan, Ka Ian. “Maternal Vitamin D Status Related to Triacylglycerol in Early Pregnancy and Subsequent Risk for Adverse Pregnancy Outcomes.” 2011. Web. 06 Mar 2021.
Vancouver:
Chan KI. Maternal Vitamin D Status Related to Triacylglycerol in Early Pregnancy and Subsequent Risk for Adverse Pregnancy Outcomes. [Internet] [Masters thesis]. University of Kansas; 2011. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1808/7937.
Council of Science Editors:
Chan KI. Maternal Vitamin D Status Related to Triacylglycerol in Early Pregnancy and Subsequent Risk for Adverse Pregnancy Outcomes. [Masters Thesis]. University of Kansas; 2011. Available from: http://hdl.handle.net/1808/7937
9.
Rockwell, Michelle S.
Vitamin D in Human Health and Performance: The Pursuit of Evidence-Based Practice in an Era of Scientific Uncertainty.
Degree: PhD, Human Nutrition, Foods, and Exercise, 2019, Virginia Tech
URL: http://hdl.handle.net/10919/93168
► Vitamin D is known as the “sunshine vitamin” since it can be synthesized by the human body when exposed to specific wavelengths of ultraviolet-B (UVB)…
(more)
▼ Vitamin
D is known as the “sunshine vitamin” since it can be synthesized by the human body when exposed to specific wavelengths of ultraviolet-B (UVB) light. Some foods and dietary supplements also contain vitamin
D. A relationship between vitamin
D and bone health is well-established, but emerging research has also associated vitamin
D status with a number of different diseases and health problems, including cancer, cardiovascular disease, autoimmune conditions, and depression. Unfortunately, this research is currently inconclusive, and healthcare providers’ professional guidelines related to vitamin
D are highly variable. Thus, providing evidence-based care related to vitamin
D is complicated. This dissertation consists of a series of three research studies that describe healthcare providers’ vitamin
D-related care considering the uncertain landscape, and two research studies that explore the role of vitamin
D in collegiate athletes. We chose athletes since a high proportion of them have deficient or insufficient vitamin
D status, and because some research has shown that this low vitamin
D status affects athletic performance. Results of these studies showed that vitamin
D-related health services such as blood testing have increased dramatically over the past 15 years, as have costs associated with these services. Opportunities to improve consistency and quality of care were observed in multiple settings. In the athlete studies, a high rate of vitamin
D deficiency and insufficiency was observed among basketball athletes, and we identified vitamin
D supplement treatment protocol effective in improving vitamin
D status. In addition, swimmers who took vitamin
D supplements performed better on strength and conditioning tests than those who took placebo supplements. A favorable relationship between testosterone concentrations and vitamin
D status was shown in both basketball athletes and swimmers. Continuing to conduct research focused on specific populations can help healthcare providers develop consistent, high quality, evidence-based care related to vitamin
D.
Advisors/Committee Members: Hulver, Matthew W. (committeechair), Davy, Kevin P. (committee member), Epling, John (committee member), Rankin, Janet L. Walberg (committee member), You, Wen (committee member).
Subjects/Keywords: Low Value Care; Screening; 25-Hydroxyvitamin D; Supplement; Athlete
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APA (6th Edition):
Rockwell, M. S. (2019). Vitamin D in Human Health and Performance: The Pursuit of Evidence-Based Practice in an Era of Scientific Uncertainty. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/93168
Chicago Manual of Style (16th Edition):
Rockwell, Michelle S. “Vitamin D in Human Health and Performance: The Pursuit of Evidence-Based Practice in an Era of Scientific Uncertainty.” 2019. Doctoral Dissertation, Virginia Tech. Accessed March 06, 2021.
http://hdl.handle.net/10919/93168.
MLA Handbook (7th Edition):
Rockwell, Michelle S. “Vitamin D in Human Health and Performance: The Pursuit of Evidence-Based Practice in an Era of Scientific Uncertainty.” 2019. Web. 06 Mar 2021.
Vancouver:
Rockwell MS. Vitamin D in Human Health and Performance: The Pursuit of Evidence-Based Practice in an Era of Scientific Uncertainty. [Internet] [Doctoral dissertation]. Virginia Tech; 2019. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10919/93168.
Council of Science Editors:
Rockwell MS. Vitamin D in Human Health and Performance: The Pursuit of Evidence-Based Practice in an Era of Scientific Uncertainty. [Doctoral Dissertation]. Virginia Tech; 2019. Available from: http://hdl.handle.net/10919/93168
Queensland University of Technology
10.
Wyatt, Candy.
Serum 25-hydroxyvitamin D concentration in relation to melanoma progress.
Degree: 2013, Queensland University of Technology
URL: https://eprints.qut.edu.au/62441/
► Dr Wyatt’s study investigated the complex relationship between vitamin D and melanoma, specifically if vitamin D status is associated with more aggressive melanomas. Exposure to…
(more)
▼ Dr Wyatt’s study investigated the complex relationship between vitamin D and melanoma, specifically if vitamin D status is associated with more aggressive melanomas. Exposure to solar ultraviolet radiation is the principal risk factor for melanoma and also the main source of vitamin D. This research found that insufficient vitamin D at time of melanoma diagnosis is significantly associated with poorer prognosis (as defined by tumour thickness). These results will contribute to a more refined public health message concerning melanoma and vitamin D, particularly in Queensland, which has the highest global incidence of melanoma, but vitamin D deficiency is not uncommon.
Subjects/Keywords: melanoma; melanoma prognosis; Breslow thickness; vitamin D; serum 25-hydroxyvitamin D; serum 25(OH)D; S-100B
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APA (6th Edition):
Wyatt, C. (2013). Serum 25-hydroxyvitamin D concentration in relation to melanoma progress. (Thesis). Queensland University of Technology. Retrieved from https://eprints.qut.edu.au/62441/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wyatt, Candy. “Serum 25-hydroxyvitamin D concentration in relation to melanoma progress.” 2013. Thesis, Queensland University of Technology. Accessed March 06, 2021.
https://eprints.qut.edu.au/62441/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wyatt, Candy. “Serum 25-hydroxyvitamin D concentration in relation to melanoma progress.” 2013. Web. 06 Mar 2021.
Vancouver:
Wyatt C. Serum 25-hydroxyvitamin D concentration in relation to melanoma progress. [Internet] [Thesis]. Queensland University of Technology; 2013. [cited 2021 Mar 06].
Available from: https://eprints.qut.edu.au/62441/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wyatt C. Serum 25-hydroxyvitamin D concentration in relation to melanoma progress. [Thesis]. Queensland University of Technology; 2013. Available from: https://eprints.qut.edu.au/62441/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Cornell University
11.
Hansen, Joyanna.
Vitamin D: Genetic And Environmental Predictors Of Status And Associations With Pulmonary Outcomes.
Degree: PhD, Nutrition, 2013, Cornell University
URL: http://hdl.handle.net/1813/34263
► Vitamin D, a pleiotropic hormone essential for calcium homeostasis, has generated widespread interest due to associations with numerous health outcomes. Cross-sectional studies of vitamin D…
(more)
▼ Vitamin
D, a pleiotropic hormone essential for calcium homeostasis, has generated widespread interest due to associations with numerous health outcomes. Cross-sectional studies of vitamin
D and lung function reported strong, positive associations, but representative, longitudinal population-based studies are lacking, and biological mechanisms are unclear. Lung function decline is the primary characteristic of chronic obstructive pulmonary disease (COPD), the 3rd leading cause of mortality in the United States; given limited treatments to delay progression, identifying preventative approaches is critical. This work aims to elucidate determinants of vitamin
D status, and investigate the role of vitamin
D as a determinant of lung function. First, we explored genetic and non-genetic determinants of serum vitamin
D [
25(OH)
D] in African Americans. Approximately
25% of
25(OH)
D variability was explained by non-genetic factors, and multivitamin supplement use was the strongest predictor. A single nucleotide polymorphism (SNP) in the vitamin
D binding protein modified the effect of multivitamin supplement use on
25(OH)
D. About 23% of
25(OH)
D variability was estimated to be attributable to genetic variation, with replication in a separate cohort. However, the influence of genetic ancestry made an exact estimate impossible; further exploration of genetic determinants of
25(OH)
D in African Americans is needed. Second, potential mechanisms for vitamin
D-lung health associations were explored through a cross-sectional study of SNPs in 13 candidate vitamin Dresponsive genes. SNPs in SGPP2, a phosphatase in the sphingosine-1-phosphate signaling pathway, were associated with lung function and COPD risk. Further, we identified an association between SNPs in SGPP2 and lung-tissue specific expression of SGPP2. While specific mechanisms remain to be investigated, SGPP2 is a promising vitamin
D-responsive candidate gene. Finally, associations between variants in vitamin
D metabolic genes, serum
25(OH)
D and lung function were explored in the Framingham Heart Study. SNPs in four vitamin
D metabolic genes were associated with rate of change in FEV1, but there was no association between
25(OH)
D and rate of change in FEV1 in the Third Generation cohort, a group of largely vitamin
D sufficient middleaged adults. Future studies should consider the influence of baseline nutritional status and underlying genetic variation on vitamin
D-disease associations.
Advisors/Committee Members: Cassano, Patricia Ann (chair), Mezey, Jason G. (committee member), Clark, Andrew (committee member), Brannon, Patsy Marie (committee member).
Subjects/Keywords: Vitamin D; Nutrition; Genetics; COPD; Epidemiology; FEV1; 25-Hydroxyvitamin D; eQTL; SGPP2; GC; supplements
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APA ·
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Manager
APA (6th Edition):
Hansen, J. (2013). Vitamin D: Genetic And Environmental Predictors Of Status And Associations With Pulmonary Outcomes. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/34263
Chicago Manual of Style (16th Edition):
Hansen, Joyanna. “Vitamin D: Genetic And Environmental Predictors Of Status And Associations With Pulmonary Outcomes.” 2013. Doctoral Dissertation, Cornell University. Accessed March 06, 2021.
http://hdl.handle.net/1813/34263.
MLA Handbook (7th Edition):
Hansen, Joyanna. “Vitamin D: Genetic And Environmental Predictors Of Status And Associations With Pulmonary Outcomes.” 2013. Web. 06 Mar 2021.
Vancouver:
Hansen J. Vitamin D: Genetic And Environmental Predictors Of Status And Associations With Pulmonary Outcomes. [Internet] [Doctoral dissertation]. Cornell University; 2013. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1813/34263.
Council of Science Editors:
Hansen J. Vitamin D: Genetic And Environmental Predictors Of Status And Associations With Pulmonary Outcomes. [Doctoral Dissertation]. Cornell University; 2013. Available from: http://hdl.handle.net/1813/34263
University of Melbourne
12.
Heath, Alicia Kathryn.
Vitamin D and the risk of death and diabetes.
Degree: 2016, University of Melbourne
URL: http://hdl.handle.net/11343/115238
► Background Uncertainty surrounds the effects of vitamin D on extraskeletal health. Many observational studies have found inverse associations between vitamin D status and several outcomes,…
(more)
▼ Background
Uncertainty surrounds the effects of vitamin D on extraskeletal health. Many observational studies have found inverse associations between vitamin D status and several outcomes, including mortality and type 2 diabetes, but these results might be biased by confounding and reverse causality. Evidence from existing randomised controlled trials (RCTs) of vitamin D supplementation is of limited utility due to design limitations. Furthermore, although recent evidence from RCTs suggests that vitamins D2 and D3 might not function equivalently, existing observational studies have generally used total 25-hydroxyvitamin D (25(OH)D) concentrations (the sum of 25-hydroxyvitamin D2 (25(OH)D2) and 25-hydroxyvitamin D3 (25(OH)D3)) to assess vitamin D status without distinguishing between 25(OH)D2 and 25(OH)D3. Thus, any differences in their associations with health outcomes have not been explored.
My principal aims were to investigate associations between vitamin D status and all-cause mortality, cause-specific mortality, and the incidence of type 2 diabetes; investigate the separate associations of 25(OH)D2 and 25(OH)D3 with all-cause mortality; and explore the possibility of reverse causality. Secondary aims were to assess the validity and reliability of measurements of 25(OH)D in dried blood spots (DBS), and investigate correlates of vitamin D status.
Methods
A case-cohort study nested within the Melbourne Collaborative Cohort Study (MCCS) was used. Concentrations of 25(OH)D2 and 25(OH)D3 in archived DBS were measured using liquid chromatography-tandem mass spectrometry. Correlates of vitamin D status were investigated using multiple linear regression. Cox regression was used to estimate hazard ratios (HRs) for mortality with adjustment for confounding variables. Barlow’s method and robust standard errors were used to account for the case-cohort design. Logistic regression was used to estimate odds ratios (ORs) in relation to type 2 diabetes.
Results
Measurements of 25(OH)D from DBS were reliable (within-batch and between-batch intraclass correlations for 493 replicate measurements = 0.82; 95% confidence interval (CI): 0.80, 0.85 and 0.73; 95% CI: 0.68, 0.78, respectively), and were highly correlated with plasma 25(OH)D (R2 from regression of plasma versus DBS 25(OH)D = 0.73). Correlates of vitamin D status were predominantly environmental, behavioural and lifestyle variables, and personal characteristics that influence sun exposure (R2 for predictive model = 0.31). Season was the strongest predictor of vitamin D status (partial R2 = 0.13).
Concentrations of 25(OH)D3 were inversely associated with all-cause mortality (HR per 25 nmol/L increase = 0.85; 95% CI: 0.77, 0.95; P = 0.003), whereas the presence of 25(OH)D2 was positively associated with all-cause mortality (HR = 1.80; 95% CI: 1.09, 2.97; P = 0.02). Higher concentrations of 25(OH)D3 were associated with a reduced risk of death due to cancer (HR per 25 nmol/L increase = 0.86; 95% CI: 0.77, 0.97; P = 0.02), respiratory diseases (HR = 0.59;…
Subjects/Keywords: vitamin D; vitamin D2; vitamin D3; 25-hydroxyvitamin D; mortality; diabetes; cancer; cardiovascular disease
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Heath, A. K. (2016). Vitamin D and the risk of death and diabetes. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/115238
Chicago Manual of Style (16th Edition):
Heath, Alicia Kathryn. “Vitamin D and the risk of death and diabetes.” 2016. Doctoral Dissertation, University of Melbourne. Accessed March 06, 2021.
http://hdl.handle.net/11343/115238.
MLA Handbook (7th Edition):
Heath, Alicia Kathryn. “Vitamin D and the risk of death and diabetes.” 2016. Web. 06 Mar 2021.
Vancouver:
Heath AK. Vitamin D and the risk of death and diabetes. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/11343/115238.
Council of Science Editors:
Heath AK. Vitamin D and the risk of death and diabetes. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/115238
University of Arizona
13.
Yousef, Fatimah Mohammadali.
Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
.
Degree: 2011, University of Arizona
URL: http://hdl.handle.net/10150/202986
► Vitamin D is an essential nutrient in the human diet. A unique property of vitamin D is that it can be produced by endogenous synthesis…
(more)
▼ Vitamin
D is an essential nutrient in the human diet. A unique property of vitamin
D is that it can be produced by endogenous synthesis in the skin following sufficient Ultraviolet B (UVB) radiation. In fact, our understanding of this compound has changed, such that it is no longer consider a true vitamin, but rather a steroid hormone. De-identified data for this analysis were derived from women residing in Jeddah, Saudi Arabia who completed routine medical visits in the summer of 2009 at King Fahad Hospital (KFH). In Chapter 1,“THE ASSOCIATION BETWEEN VITAMIN
D STATUS IN NORMAL WEIGHT VERSUS OBESE WOMEN RESIDING IN WESTERN SAUDI ARABIA” we evaluate the relationship between body size and serum
25(OH)
D concentrations including the association between change in body size during adulthood and vitamin
D status. This study examines whether the current weight and weight change since age 18 years are associated with vitamin
D status. This study found that neither current weight nor adult weight gain were associated with vitamin
D status in Saudi Arabian women. In chapter 2,“IS AVOIDING SUN EXPOSURE VIA SUN PROTECTION PRACTICES ASSOCIATED WITH LOW VITAMIN
D STATUS IN SAUDI ARABIAN WOMEN?” we investigate whether women who avoid UV exposure have lower
25(OH)
D concentrations than women who do not avoid exposure. UV exposure was defined by time in outdoor activities, use of protective clothing and sunscreen. This study demonstrated that avoiding UV exposure via indoor activity and the use of sunscreen or/and wearing protective clothing was not associated with vitamin
D status. Chapter 3, “VITAMIN
D STATUS AND BREAST CANCER IN SAUDI ARABIAN WOMEN: A CASE CONTROL STUDY” we examine if vitamin
D status as assessed by serum concentrations of
25(OH)
D would be lower in breast cancer cases as compared to controls. This study demonstrated that there is a significant relationship between higher serum concentrations of
25(OH)
D and lower risk of breast cancer. Chapter 4, “IMPLICATIONS AND FUTURE DIRECTIONS” is presented a summary of key findings from the three studies in this dissertation to determine avenues of further research. The appendices consist of materials related to the dissertation work.
Advisors/Committee Members: Thomson, Cynthia A (advisor), Jacobs, Elizabeth (committeemember), Going, Scott (committeemember), Hakim, Iman A. (committeemember), Thomson, Cynthia A. (committeemember).
Subjects/Keywords: obesity;
outdoors activity;
Saudi Arabia;
vitamin D;
Nutritional Sciences;
25-hydroxyvitamin D;
breast cancer
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APA ·
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CSE |
Export
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Manager
APA (6th Edition):
Yousef, F. M. (2011). Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/202986
Chicago Manual of Style (16th Edition):
Yousef, Fatimah Mohammadali. “Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
.” 2011. Doctoral Dissertation, University of Arizona. Accessed March 06, 2021.
http://hdl.handle.net/10150/202986.
MLA Handbook (7th Edition):
Yousef, Fatimah Mohammadali. “Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
.” 2011. Web. 06 Mar 2021.
Vancouver:
Yousef FM. Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
. [Internet] [Doctoral dissertation]. University of Arizona; 2011. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10150/202986.
Council of Science Editors:
Yousef FM. Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study
. [Doctoral Dissertation]. University of Arizona; 2011. Available from: http://hdl.handle.net/10150/202986
University of Georgia
14.
Ferira, Ashley Jordan.
Vitamin D, insulin sensitivity, and cardiometabolic risk in children.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/27717
► Background: The childhood obesity epidemic has increased the prevalence of cardiometabolic disease and pre-diabetes prevalence. Vitamin D’s role in diabetes and cardiometabolic disease is an…
(more)
▼ Background: The childhood obesity epidemic has increased the prevalence of cardiometabolic disease and pre-diabetes prevalence. Vitamin D’s role in diabetes and cardiometabolic disease is an emerging, extraskeletal function that has been
explored via mechanistic research, as well as observational and intervention studies, predominantly in adults. Objective: To review the relevant literature, report the effects of vitamin D supplementation on glycemia and insulin sensitivity in apparently
healthy children, and examine the cross-sectional relationship between serum vitamin D and cardiometabolic risk in overweight children. Methods: The intervention trial includes black and white early pubertal (N = 320) males (aged 10 to 13 years) and
females (aged 9 to 12 years) who participated in a 12-week randomized, triple masked, multi-site, five-dose (0, 400, 1,000, 2000, and 4,000 IU vitamin D3) placebo-controlled trial. The cross-sectional study includes 222 sedentary, overweight children
(aged 7-11 years, 58% female, 58% black, 86% obese). Anthropometry, body composition, and biochemical indices related to serum vitamin D status, glucose-insulin homeostasis, and cardiometabolic risk were examined in both studies. Results: The vitamin D
intervention did not significantly alter glycemia or insulin sensitivity over 12-weeks. Glucose, insulin, and insulin resistance increased, while insulin sensitivity decreased, over the 12-weeks, likely attributable to organic pubertal maturation
phenomena. Lower serum vitamin D concentrations were associated with multiple cardiometabolic risk factors, insulin resistance, and adipokines and associated with an increase in cardiometabolic disease risk, however, model adjustment with visceral
adipose tissue attenuated all of these relationships. Conclusions: We report novel findings from the first pediatric vitamin D intervention to examine effects on glycemia and insulin sensitivity. In this trial, the apparently healthy, vitamin D
sufficient status of our children, are key facets that may have contributed to our null finding. Furthermore, we may have avoided the glucose-insulin homeostatic alterations induced by pubertal growth if we had examined a pre- or post-pubertal
population. Our cross-sectional findings highlight the important mediating role of visceral adiposity in the vitamin D-cardiometabolic disease relationship. Future, rigorously designed trials are warranted to elucidate the causal effect of vitamin D on
cardiovascular disease and diabetes, with particular attention paid to pediatric populations with higher cardiometabolic risk and vitamin D insufficiency.
Subjects/Keywords: 25-hydroxyvitamin D; vitamin D; insulin sensitivity; diabetes; cardiometabolic; obesity; children; pediatric
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APA ·
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Manager
APA (6th Edition):
Ferira, A. J. (2014). Vitamin D, insulin sensitivity, and cardiometabolic risk in children. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/27717
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ferira, Ashley Jordan. “Vitamin D, insulin sensitivity, and cardiometabolic risk in children.” 2014. Thesis, University of Georgia. Accessed March 06, 2021.
http://hdl.handle.net/10724/27717.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ferira, Ashley Jordan. “Vitamin D, insulin sensitivity, and cardiometabolic risk in children.” 2014. Web. 06 Mar 2021.
Vancouver:
Ferira AJ. Vitamin D, insulin sensitivity, and cardiometabolic risk in children. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10724/27717.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ferira AJ. Vitamin D, insulin sensitivity, and cardiometabolic risk in children. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/27717
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Georgia
15.
Stein, Elizabeth.
Serum 25(OH)D concentrations in girls aged 4-8 years in the southeast United States.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/22809
► Increasing evidence suggests that adults and adolescents throughout the United States are atrisk for poor vitamin D status, but vitamin D levels of young children…
(more)
▼ Increasing evidence suggests that adults and adolescents throughout the United States are atrisk for poor vitamin D status, but vitamin D levels of young children in the United Stateshave not been assessed. Serum 25(OH)D was assessed in
prepubertal females, aged four toeight years (n=168) living in southeast United States and relationships were examined withbone and body composition. Serum 25(OH)D was assessed using radioimmunoassay(DiaSorin Laboratories), and bone area (BA), bone
mineral content (BMC), and areal bonemineral density (aBMD) was measured using dual-energy X-ray absorptiometry (HologicQDR-1000W). Data were analyzed using ANOVA, ANCOVA, stepwise multiple regression,and partial correlations. Mean serum 25(OH)D was 93.8
nmol/l (SD 28.1, range 31.1-181.4 ).The multiple regression model identified race and season as the strongest predictors ofvitamin D status. Black girls had significantly lower mean 25(OH)D values than white girls(p <0.01), and mean values were
significantly different between seasons in the total sample(F=11.87, p<0.001), ranging from 74.4 nmol/l in participants tested in the winter months to107 nmol/l in those tested in the summer. Furthermore, after adjusting for season, age, race,and BMI,
25(OH)D values had no significant associations with bone variables, except for anegative partial correlation with forearm BMC (r=-0.182; p=0.021). In black girls only, age,calcium intake, and household income were significantly associated with 25(OH)D
(r=-0.41,0.36, 0.31, respectively) . Unlike some prior reports of adults and adolescents living in thesoutheast United States, vitamin D status was adequate among the prepubertal girls in thisstudy. Moreover, 25(OH)D levels were not positively associated
with higher bone mineral inthese children. This project was funded by National Institute on Child Health and HumanDevelopment grant 1 RO1 HD 35592-01A1.
Subjects/Keywords: BONE MINERAL DENSITY; GEORGIA; PREPUBERTAL GIRLS,RACE; SEASON; SERUM 25-HYDROXYVITAMIN D; VITAMIN D
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APA ·
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CSE |
Export
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Manager
APA (6th Edition):
Stein, E. (2014). Serum 25(OH)D concentrations in girls aged 4-8 years in the southeast United States. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/22809
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stein, Elizabeth. “Serum 25(OH)D concentrations in girls aged 4-8 years in the southeast United States.” 2014. Thesis, University of Georgia. Accessed March 06, 2021.
http://hdl.handle.net/10724/22809.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stein, Elizabeth. “Serum 25(OH)D concentrations in girls aged 4-8 years in the southeast United States.” 2014. Web. 06 Mar 2021.
Vancouver:
Stein E. Serum 25(OH)D concentrations in girls aged 4-8 years in the southeast United States. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10724/22809.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stein E. Serum 25(OH)D concentrations in girls aged 4-8 years in the southeast United States. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/22809
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Sydney
16.
Huang, Alice.
Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & Protein Expression: Complex Extracellular Ca2+ Concentration Dependence
.
Degree: 2018, University of Sydney
URL: http://hdl.handle.net/2123/20127
► Changes in extracellular Ca2+ (Ca2+o) differentially modulate 25-hydroxyvitamin D3 1α-hydroxylase (1αOHase; encoded by CYP27B1) mRNA and protein levels in cell types including the renal proximal…
(more)
▼ Changes in extracellular Ca2+ (Ca2+o) differentially modulate 25-hydroxyvitamin D3 1α-hydroxylase (1αOHase; encoded by CYP27B1) mRNA and protein levels in cell types including the renal proximal tubule (inhibitory), parathyroid, and skeletal osteoblasts (stimulatory) to control 1,25-dihydroxyvitamin D3 synthesis. We hypothesised that the calcium-sensing receptor (CaSR) mediated Ca2+o concentration-dependent control of 1αOHase, either directly through Ca2+o, or through the local production of parathyroid hormone related peptide (PTHrP). To investigate promoter activity, I transfected a firefly luciferase reporter gene under the control of the 1501 bp human CYP27B1 promoter into HEK-293 cells that stably expressed the CaSR (HEK-CaSR cells) and measured luciferase activities from cells exposed to various Ca2+o concentrations. CYP27B1 promoter-controlled luciferase expression exhibited a biphasic Ca2+o-dependent response in luciferase activity and protein that peaked with a 2-fold increase from basal levels at around 3.0 mM Ca2+o in HEK-CaSR cells. This response was absent in HEK-293 cells and was shifted to the left or right in the presence of the CaSR positive allosteric modulator, cinacalcet, or negative allosteric modulator, NPS-2143, respectively, indicating that both the stimulatory and inhibitory phases were CaSR-mediated. Firefly luciferase and 1αOHase mRNA levels obtained from quantitative RT-PCR exhibited a monophasic Ca2+o-dependent increase and suggests that the stimulatory phase arises from increased mRNA expression, whereas the inhibitory phase arises from reduced protein levels. Inhibitor and mutational studies suggested that the stimulatory phase was dependent on Gq/11 signalling, whereas the inhibitory phase requires MEK and PKC-dependent phosphorylation of the crucial T888 site of the CaSR's C-terminal tail.
Subjects/Keywords: calcium;
calcium-sensing receptor;
vitamin D;
25-hydroxyvitamin D 1a-hydroxylase;
CYP27B1
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APA ·
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APA (6th Edition):
Huang, A. (2018). Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & Protein Expression: Complex Extracellular Ca2+ Concentration Dependence
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/20127
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Huang, Alice. “Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & Protein Expression: Complex Extracellular Ca2+ Concentration Dependence
.” 2018. Thesis, University of Sydney. Accessed March 06, 2021.
http://hdl.handle.net/2123/20127.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Huang, Alice. “Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & Protein Expression: Complex Extracellular Ca2+ Concentration Dependence
.” 2018. Web. 06 Mar 2021.
Vancouver:
Huang A. Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & Protein Expression: Complex Extracellular Ca2+ Concentration Dependence
. [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/2123/20127.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Huang A. Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & Protein Expression: Complex Extracellular Ca2+ Concentration Dependence
. [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/20127
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
17.
Bella, Leonardo Mendes.
Estudo da suplementação de vitamina D em modelo experimental de diabetes mellitus.
Degree: Mestrado, Análises Clínicas, 2014, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04052015-090905/
;
► O diabetes mellitus (DM) é uma doença com prevalência e morbidade elevadas em todo o mundo, sendo que o DM1 é responsável por 5-10% dos…
(more)
▼ O diabetes mellitus (DM) é uma doença com prevalência e morbidade elevadas em todo o mundo, sendo que o DM1 é responsável por 5-10% dos casos. A vitamina D, hormônio de ação pleiotrópica, pode melhorar o curso do DM1, embora os mecanismos não estejam completamente elucidados. Dessa forma, ampliar o conhecimento sobre a ação desse hormônio pode auxiliar no prognóstico, bem como na compreensão dos possíveis mecanismos envolvidos na prevenção do DM. Neste trabalho, foram avaliados os efeitos fisiológicos da suplementação de vitamina D (800 UI/dia/sete dias; via oral) em camundongos machos (n=31; linhagem C57BL/6) distribuídos em quatro grupos: Controle + Água (CA; n=9); Controle + Vitamina D (CV; n=9); Diabético + Água (DA; n=6) e Diabético + Vitamina D (DV; n=7). Os camundongos tornados diabéticos (aloxana, 60 mg/Kg, intravenosa), quando comparados aos controles, exibiram redução do peso corporal e concentrações plasmáticas de glicose mais elevadas durante o período experimental de 10 dias (características do estado insulinopênico). Entretanto, a suplementação com vitamina D não alterou essa condição. Camundongos tornados diabéticos, em relação aos controles, exibiram redução do peso corporal (p<0,05) e concentrações plasmáticas de glicose (p<0,001) mais elevadas durante o período experimental. Animais suplementados com vitamina D apresentaram, em relação aos controles, níveis de 25(OH)D mais elevados (CA vs CV, p<0,001; DA vs DV, p<0,001). Níveis séricos maiores de ureia (CA vs DA, p<0,05; CA vs DV, p<0,01; CV vs DA, p<0,05; CV vs DV, p<0,01) e creatinina (CA vs DA, p<0,001; CA vs DV, p<0,001; CV vs DA, p<0,001; CV vs DV, p<0,001), espessamento da cápsula de Bowman, hipertrofia glomerular e destruição de hepatócitos foram observados em camundongos diabéticos em relação aos controles. Entretanto, a suplementação com vitamina D não alterou estas condições. O grupo DA apresentou menor nível sérico de albumina em relação aos grupos CA (p<0,05) e CV (p<0,05); níveis inferiores de hemoglobina (p<0,05) e hematócrito (p<0,05) em relação ao grupo DV; e menor leucometria (p<0,05) e mononucleares sanguíneos (p<0,05) em relação ao grupo CA. Os resultados sugerem que a vitamina D possa influenciar a resposta imunológica em animais diabéticos, modulando hematócrito, hemoglobina, bem como os níveis séricos de albumina
Diabetes mellitus (DM) is a disease with high prevalence and morbidity worldwide, and the DM1 is responsible for 5-10% of cases. The vitamin D hormone pleiotropic action, can improve the course of T1DM, although the mechanisms are not fully elucidated. Thus, better understanding the action of this hormone can aid in prognosis as well as in understanding the possible mechanisms involved in the prevention of diabetes. We evaluated the physiological effects of vitamin D (800 IU/day/seven days, v.o.) in male mice (n=31, C57BL/6 strain) divided into four groups: Control + Water (CW, n=9); Control Vitamin D + (CV n=9); Diabetic + Water (DW, n=6) Diabetic + Vitamin D (VD, n=7). The mice induced-diabetes by alloxan (60…
Advisors/Committee Members: Martins, Joilson de Oliveira.
Subjects/Keywords: 25-hidroxivitamina D; 25-hydroxyvitamin D; Alloxan; Aloxana; Cholecalciferol; Colecalciferol; Diabetes mellitus; Diabetes mellitus; Hiperglicemia; Hyperglycemia; Immune system; Sistema imune
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bella, L. M. (2014). Estudo da suplementação de vitamina D em modelo experimental de diabetes mellitus. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04052015-090905/ ;
Chicago Manual of Style (16th Edition):
Bella, Leonardo Mendes. “Estudo da suplementação de vitamina D em modelo experimental de diabetes mellitus.” 2014. Masters Thesis, University of São Paulo. Accessed March 06, 2021.
http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04052015-090905/ ;.
MLA Handbook (7th Edition):
Bella, Leonardo Mendes. “Estudo da suplementação de vitamina D em modelo experimental de diabetes mellitus.” 2014. Web. 06 Mar 2021.
Vancouver:
Bella LM. Estudo da suplementação de vitamina D em modelo experimental de diabetes mellitus. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2021 Mar 06].
Available from: http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04052015-090905/ ;.
Council of Science Editors:
Bella LM. Estudo da suplementação de vitamina D em modelo experimental de diabetes mellitus. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04052015-090905/ ;
Univerzitet u Beogradu
18.
Vuksanović, Miljanka, 1972-.
Povezanost nivoa vitamina D i pojave sarkopenije i
osteopenije kod žena sa metaboličkim sindromom u
postmenopauzi.
Degree: Medicinski fakultet, 2017, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:16073/bdef:Content/get
► Medicina - Endokrinologija / Medicine - Endocrinology
Niska koncentracija serumskog 25-hidroksivitamina D (25OHvitD) je povezana sa gubitkom koštane gustine i rizikom od pada kod žena…
(more)
▼ Medicina - Endokrinologija / Medicine -
Endocrinology
Niska koncentracija serumskog 25-hidroksivitamina D
(25OHvitD) je povezana sa gubitkom koštane gustine i rizikom od
pada kod žena u postmenopauzi. Ispitati koncetraciju 25OHvitD kod
žena u postmenopauzi i njegov uticaj na telesni sastav, koštanu
gustinu, mišićnu snagu, metabolički sindrom. METOD: Ovo je bila
opservaciona, analitička studija, koja je uključila
postmenopauzalne žene od 45 - 70 godina starosti. Uključene su žene
koje su prvi put došle na merenje koštane gustine
dvostruko-energetskom apsorpciometrijom X-zracima (DXA).
Procenjivani su: obim struka (OS), indeks telesne maste (ITM),
koštana gustina (BMD), glukoza, insulinska rezistencija (HOMA-IR),
25OHD, test mišićne snage (HGT), indeks telesne masti (FMI) i
apendikularna mišićna masa (AMM) pomoću DXA aparata. REZULTATI:
Prosečna starost žena je bila 57,16±5,71 godina. Početak menopauze
kod ispitanica je bio sa 49,59±4,02 godina. Trajanje menopauze u
proseku je bilo 7,51±4,99 godina. Prema dobijenom indeksu telesne
mase (ITM) 28,03±4,65kg/m2, ispitivane postmenopauzalne žene bile
su preterano uhranjene i imale su obim struka (OS) 91,56±10,85cm.
Prosečna vrednost 25(OH)D iznosila je 39,43±16,73 nmol/L. Nije bilo
ispitanica sa normalnim koncentracijama vitamina D. Insuficijenciju
vitamina D imalo je 76,2 %. Pacijentkinje su imale osteopeniju.
Prosečna mišićna snaga iznosila je 12,44±2,24kg i bila je
statistički značajno niža u odnosu na normative za životnu dob(t =
-21.65; p <0,001). Indeks skeletne mišićne mase (SMI) iznosio je
6,72±0,91kg/m2, tako da kod pacijentkinja nije potvrđena
sarkopenija. Nađena je pozitivna korelacija između 25(OH)D i testa
mišićne snage (R=0,227; p=0,022). Metabolički sindrom imalo je čak
69% ispitanica i potvrđena je korelacija 25OHD sa parametrima
metaboličkog sindroma, obimom struka (R2=0,094; p=0,004),
glikemijom našte (R2=-0,046; p=0,030), insulinskom rezistencijom
(HOMA-IR) (R=-0,238; p=0,017) i indeksom telesne mase (R2=0,080;
p=0,002). Procenat telesnih masti iznosio je 43,54±4,83% ,
statistički značajno više u odnosu na referente vrednosti za istu
životnu dob (z=-2.575; p= 0.005). ZAKLJUČAK: Umereno gojazne
posmenopauzalne žene imaju insuficijenciju vitamin D koja je
povezana sa većim obimom struka, smajenom mišićnom snagom, većim
procentom telesnih masti i parametrima metaboličkog
sindroma.
Advisors/Committee Members: Beljić-Živković, Teodora, 1959-.
Subjects/Keywords: 25-hydroxyvitamin D; hand grip strength; dynapenia;
postmenopause; metabolic syndrome; fat mass index
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vuksanović, Miljanka, 1. (2017). Povezanost nivoa vitamina D i pojave sarkopenije i
osteopenije kod žena sa metaboličkim sindromom u
postmenopauzi. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:16073/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vuksanović, Miljanka, 1972-. “Povezanost nivoa vitamina D i pojave sarkopenije i
osteopenije kod žena sa metaboličkim sindromom u
postmenopauzi.” 2017. Thesis, Univerzitet u Beogradu. Accessed March 06, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:16073/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vuksanović, Miljanka, 1972-. “Povezanost nivoa vitamina D i pojave sarkopenije i
osteopenije kod žena sa metaboličkim sindromom u
postmenopauzi.” 2017. Web. 06 Mar 2021.
Vancouver:
Vuksanović, Miljanka 1. Povezanost nivoa vitamina D i pojave sarkopenije i
osteopenije kod žena sa metaboličkim sindromom u
postmenopauzi. [Internet] [Thesis]. Univerzitet u Beogradu; 2017. [cited 2021 Mar 06].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:16073/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vuksanović, Miljanka 1. Povezanost nivoa vitamina D i pojave sarkopenije i
osteopenije kod žena sa metaboličkim sindromom u
postmenopauzi. [Thesis]. Univerzitet u Beogradu; 2017. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:16073/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
19.
Nordqvist, Malin.
Effects of 25-hydroxyvitamin D3 and digitoxin in prostate cancer cells.
Degree: Health and Education, 2017, University of Skövde
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13875
► Prostate cancer is the most occurring form of cancer in men in Sweden and new candidates for treatment towards advanced phases of prostate cancer…
(more)
▼ Prostate cancer is the most occurring form of cancer in men in Sweden and new candidates for treatment towards advanced phases of prostate cancer needs to be investigated. One suggested treatment is vitamin D which will mediate effect via VDR and PDIA3 and cause cell cycle arrest. Another treatment is digitoxin which will cause accumulation of intracellular Ca2+ leading to apoptosis. The aim of the project of was to investigate potential synergistic effects of 25-hydroxyvitamin D3 and digitoxin in prostate cancer cell lines and find out effects mediated by PDIA3. DU145 and LNCaP cells were seeded and treated with 25-hydroxyvitamin D3 (10-10, 10-9, 10-7 M), digitoxin (25 ng/ml and 50 ng/ml) and four combinations of 25-hydroxyvitamin D3 and digitoxin. Cell viability assay was performed for determining the number of viable cells. Treatment with 25-hydroxyvitamin D3 10-7M + digitoxin 50ng/ml (68%), 25-hydroxyvitamin D3 10-9M + digitoxin 25ng/ml (39%), 25-hydroxyvitamin D3 10-9M + digitoxin 50ng/ml (69%), digitoxin 25ng/ml (26%) and digitoxin 50 ng/ml (44%) was statistically significant with increased cell viability compared to untreated control in DU145 after 48h of treatment. Treatment with 25-hydroxyvitamin D3 10-7M (12%) and 25-hydroxyvitamin D3 10-9M (12%) was statistically significant with increased cell viability compared to untreated control in LNCaP after 24h of treatment. The conclusion based on results from this study is that a combination of digitoxin and 25-hydroxyvitamin D3 does not inhibit cell viability in DU145 or LNCaP cancer cell lines.
Subjects/Keywords: Prostate cancer; 25-hydroxyvitamin D3; Vitamin D; Digitoxin; Medical and Health Sciences; Medicin och hälsovetenskap
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nordqvist, M. (2017). Effects of 25-hydroxyvitamin D3 and digitoxin in prostate cancer cells. (Thesis). University of Skövde. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13875
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nordqvist, Malin. “Effects of 25-hydroxyvitamin D3 and digitoxin in prostate cancer cells.” 2017. Thesis, University of Skövde. Accessed March 06, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13875.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nordqvist, Malin. “Effects of 25-hydroxyvitamin D3 and digitoxin in prostate cancer cells.” 2017. Web. 06 Mar 2021.
Vancouver:
Nordqvist M. Effects of 25-hydroxyvitamin D3 and digitoxin in prostate cancer cells. [Internet] [Thesis]. University of Skövde; 2017. [cited 2021 Mar 06].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13875.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nordqvist M. Effects of 25-hydroxyvitamin D3 and digitoxin in prostate cancer cells. [Thesis]. University of Skövde; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13875
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
Jakopin, Eva.
Pomanjkanje vitamina D pri bolnikih zdrhttp://dkum.uni-mb.si/Dokument.php?id=56194avljenih s kronično hemodializo in njegovo nadomeščanje z visokimi odmerki holekalciferola.
Degree: 2013, Univerza v Mariboru
URL: https://dk.um.si/IzpisGradiva.php?id=40891
;
https://dk.um.si/Dokument.php?id=56194&dn=
;
https://plus.si.cobiss.net/opac7/bib/267459584?lang=sl
► Uvod Pogost zaplet kronične ledvične bolezni (KLB) je mineralna in kostna ledvična bolezen (KLB-MKB), v sklopu te pa pomanjkanje vitamina D. Vzroki so hiperfosfatemija, hipokalcemija…
(more)
▼ Uvod
Pogost zaplet kronične ledvične bolezni (KLB) je mineralna in kostna ledvična bolezen (KLB-MKB), v sklopu te pa pomanjkanje vitamina
D. Vzroki so hiperfosfatemija, hipokalcemija ter zmanjšano ledvično nastajanje aktivnega vitamina
D. Vitamin
D vpliva na kostno-mineralni metabolizem, deluje protivnetno, protitumorsko, zavira avtoimunske bolezni, srčnožilne bolezni, sladkorno bolezen, itd. Za hemodializne (HD) bolnike pomanjkanje vitamina
D dokazano predstavlja višje tveganje za celokupno umrljivost. Zaenkrat obstajajo le priporočila Kidney Disease Outcomes Quality Initiative (K/DOQI) za nadomeščanje vitamina
D pri bolnikih s KLB stopnje 3 in 4. Glede na prisotnost izvenledvične hidroksilaze se priporoča nadomeščanje z visokimi odmerki neaktivnih oblik.
Cilji
Glede na dokazano višjo umrljivost pri pomanjkanju vitamina
D pri HD bolnikih in odsotnost uradnih priporočil za nadomeščanje, smo se odločili za raziskavo na podlagi katere bi izdelali svoj protokol nadomeščanja.
Bolniki in metode
Prospektivna raziskava je potekala od maja 2008 do maja 2010 v dializnem centru Univerzitetnega kliničnega centra Maribor. Bolnikom smo v začetku raziskave in nato vsake 4 mesece določali vrednost
25-hidroksivitamina
D (
25(OH)
D), intaktnega parathormona (iPTH), kalcija (Ca) in fosfata (P). Bolniki z vrednostjo
25(OH)
D < 75 nmol/L so enkrat mesečno prejeli 40.000 IE holekalciferola per os (Plivit D3®) 3 mesece zaporedoma. Ob kontrolah smo pri bolnikih s
25(OH)
D < 75 nmol/L zdravljenje nadaljevali, pri
25(OH)
D > 75 nmol/L pa smo zdravljenje do naslednje kontrole prekinili.
Rezultati
Od 101 bolnikov je bilo 52 (51,5%) moških in 49 (48,5%) žensk, starih 63,3 ± 13,5 let. Ob začetku raziskave so bili s HD zdravljeni v povprečju 69,1 ± 66,5 mesecev. Izgubili smo 36 (35,6%) bolnikov: 16 (44,4%) jih je umrlo, 11 (30,6%) je imelo presajeno ledvico, 9 (
25%) je zamenjalo dializni center.
Na začetku raziskave so 3 (3,0%) imeli zadostne zaloge vitamina
D, 29 (28,7%) nezadostne, 52 (51,5%) blago pomanjkanje in 17 (16,8%) hudo pomanjkanje. Moški so imeli statistično značilno višjo začetno vrednost
25(OH)
D kot ženske (p = 0,007). Bolniki mlajši od 67 let so imeli statistično značilno višjo začetno vrednost
25(OH)
D kot starejši (p < 0,001). Med skupinami ni bilo razlik v končnih vrednostih
25(OH)
D.
Ob koncu raziskave je imelo 50 bolnikov (76,9%) nezadostno vrednost
25(OH)
D, 9 (13,8%) blago pomanjkanje in 6 (9,2%) zadostne zaloge. Od prvega ciklusa zdravljenja ni bilo več bolnikov s hudim pomanjkanjem.
Povprečna vrednost Ca se je med raziskavo znižala iz 2,28 ± 0,14 mmol/L na 2,16 ± 0,17 mmol/L (p < 0,001), povprečna vrednost
25(OH)
D pa zvišala iz 28,6 ± 16,7 mmol/L na 54,9 ± 15,5 nmol/L (p < 0,001). Nismo ugotavljali statistično značilnih sprememb v koncentracijah iPTH in P.
Bolniki, ki so raziskavo zaključili (n = 65), so v povprečju prejeli 12,9 ± 3,9 (mediana 12) odmerkov holekalciferola. Od tega je 29,2% (n = 19) bolnikov prejelo 12 odmerkov, 24,6% (n = 16) bolnikov 15 odmerkov, 21,5% (n = 14) bolnikov 18 odmerkov, 13,8% (n = 9) 6…
Advisors/Committee Members: Pečovnik Balon, Breda.
Subjects/Keywords: hemodializa; holekalciferol; nadomeščanje vitamina D; pomanjkanje vitamina D; 25-hidroksivitamin D; haemodialysis; cholecalciferol; vitamin D supplementation; vitamin D deficiency; 25-hydroxyvitamin D
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jakopin, E. (2013). Pomanjkanje vitamina D pri bolnikih zdrhttp://dkum.uni-mb.si/Dokument.php?id=56194avljenih s kronično hemodializo in njegovo nadomeščanje z visokimi odmerki holekalciferola. (Doctoral Dissertation). Univerza v Mariboru. Retrieved from https://dk.um.si/IzpisGradiva.php?id=40891 ; https://dk.um.si/Dokument.php?id=56194&dn= ; https://plus.si.cobiss.net/opac7/bib/267459584?lang=sl
Chicago Manual of Style (16th Edition):
Jakopin, Eva. “Pomanjkanje vitamina D pri bolnikih zdrhttp://dkum.uni-mb.si/Dokument.php?id=56194avljenih s kronično hemodializo in njegovo nadomeščanje z visokimi odmerki holekalciferola.” 2013. Doctoral Dissertation, Univerza v Mariboru. Accessed March 06, 2021.
https://dk.um.si/IzpisGradiva.php?id=40891 ; https://dk.um.si/Dokument.php?id=56194&dn= ; https://plus.si.cobiss.net/opac7/bib/267459584?lang=sl.
MLA Handbook (7th Edition):
Jakopin, Eva. “Pomanjkanje vitamina D pri bolnikih zdrhttp://dkum.uni-mb.si/Dokument.php?id=56194avljenih s kronično hemodializo in njegovo nadomeščanje z visokimi odmerki holekalciferola.” 2013. Web. 06 Mar 2021.
Vancouver:
Jakopin E. Pomanjkanje vitamina D pri bolnikih zdrhttp://dkum.uni-mb.si/Dokument.php?id=56194avljenih s kronično hemodializo in njegovo nadomeščanje z visokimi odmerki holekalciferola. [Internet] [Doctoral dissertation]. Univerza v Mariboru; 2013. [cited 2021 Mar 06].
Available from: https://dk.um.si/IzpisGradiva.php?id=40891 ; https://dk.um.si/Dokument.php?id=56194&dn= ; https://plus.si.cobiss.net/opac7/bib/267459584?lang=sl.
Council of Science Editors:
Jakopin E. Pomanjkanje vitamina D pri bolnikih zdrhttp://dkum.uni-mb.si/Dokument.php?id=56194avljenih s kronično hemodializo in njegovo nadomeščanje z visokimi odmerki holekalciferola. [Doctoral Dissertation]. Univerza v Mariboru; 2013. Available from: https://dk.um.si/IzpisGradiva.php?id=40891 ; https://dk.um.si/Dokument.php?id=56194&dn= ; https://plus.si.cobiss.net/opac7/bib/267459584?lang=sl
Universidade do Rio Grande do Sul
21.
Marcondes, Natália Aydos.
Avaliação dos níveis de 25-hidroxivitamina D e fatores associados em população não pediátrica portadora de fibrose cística.
Degree: 2013, Universidade do Rio Grande do Sul
URL: http://hdl.handle.net/10183/115588
► Introdução: Portadores de fibrose cística têm uma susceptibilidade à deficiência de vitamina D devido à má absorção de nutrientes. Os estudos da prevalência de hipovitaminose…
(more)
▼ Introdução: Portadores de fibrose cística têm uma susceptibilidade à deficiência de vitamina D devido à má absorção de nutrientes. Os estudos da prevalência de hipovitaminose D em pacientes com fibrose cística apresentam resultados extremamente variáveis e não há dados a respeito da população não pediátrica no Brasil. Objetivos: Avaliar a prevalência de hipovitaminose D em pacientes não pediátricos portadores de fibrose cística e os fatores associados com as concentrações séricas de 25-hidroxivitamina D. Metodologia: Realizado estudo transversal. A população em estudo foi composta por pacientes maiores que 16 anos acompanhados no Ambulatório de Fibrose Cística do Hospital de Clínicas de Porto Alegre. Foi avaliada a prevalência de deficiência de vitamina D, definida como 25-hidroxivitamina D < 30ng/mL, de acordo com a Cystic Fibrosis Foundation, bem como os fatores clínicos e laboratoriais associados com o valor sérico desta. Foram avaliados o estado nutricional e internações hospitalares. Foi realizada coleta de dados em prontuário, entrevista com os pacientes e colheita de sangue. As análises laboratoriais foram realizadas no Laboratório de Patologia Clínica do Hospital. Foram dosados os valores séricos de proteína C-reativa, cálcio, fosfato, magnésio, albumina, 25-hidroxivitamina D (método: quimiluminescência) e paratormônio (método: imunoensaio para PTH intacto). A função pulmonar foi avaliada por espirometria e escores clínicos e radiológicos. O nível de significância estatística foi estabelecido como P<0,05. Resultados: A prevalência de hipovitaminose D foi de 61,0%, com valores séricos de 25-hidroxivitamina D de 28,42±10,94 ng/mL. Os pacientes com insuficiência pancreática apresentaram uma tendência a ter concentrações mais altas de vitamina D. Dezesseis pacientes apresentavam doença pulmonar grave, com FEV1% do predito inferior a 40%. Após análise multivariada, índice de massa corporal e hospitalizações no último mês permaneceram significativamente associados negativamente aos valores séricos de 25-hidroxivitamina D. Conclusões: A prevalência de hipovitaminose D no presente estudo foi inferior a previamente relatada. A insuficiência de vitamina D continua sendo um problema nos pacientes com fibrose cística, mesmo naqueles recebendo suplementação.
Introduction: Cystic fibrosis patients have a susceptibility to vitamin D deficiency due to nutrient malabsorption. Prevalence studies of hypovitaminosis D in patients with cystic fibrosis have highly variable results and there is no data about the non pediatric population in Brazil. Objectives: To evaluate the prevalence of hypovitaminosis D in non pediactric cystic fibrosis patients and the factors associated with serum 25-hydroxyvitamin D levels. Methods: Cross-sectional study. The study population was composed of patients older than 16 years accompanied in the Cystic Fibrosis Ambulatory of the Hospital de Clínicas de Porto Alegre. We evaluated the prevalence of vitamin D deficiency defined as 25-hydroxyvitamin D < 30 ng/mL, as suggested recently by the Cystic…
Advisors/Committee Members: Faulhaber, Gustavo Adolpho Moreira.
Subjects/Keywords: Cystic fibrosis; Fibrose cística; Deficiência de vitamina D; 25-hydroxyvitamin D; Vitamin D deficiency; Pulmonary function; Nutrition
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APA (6th Edition):
Marcondes, N. A. (2013). Avaliação dos níveis de 25-hidroxivitamina D e fatores associados em população não pediátrica portadora de fibrose cística. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/115588
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Marcondes, Natália Aydos. “Avaliação dos níveis de 25-hidroxivitamina D e fatores associados em população não pediátrica portadora de fibrose cística.” 2013. Thesis, Universidade do Rio Grande do Sul. Accessed March 06, 2021.
http://hdl.handle.net/10183/115588.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Marcondes, Natália Aydos. “Avaliação dos níveis de 25-hidroxivitamina D e fatores associados em população não pediátrica portadora de fibrose cística.” 2013. Web. 06 Mar 2021.
Vancouver:
Marcondes NA. Avaliação dos níveis de 25-hidroxivitamina D e fatores associados em população não pediátrica portadora de fibrose cística. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2013. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10183/115588.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Marcondes NA. Avaliação dos níveis de 25-hidroxivitamina D e fatores associados em população não pediátrica portadora de fibrose cística. [Thesis]. Universidade do Rio Grande do Sul; 2013. Available from: http://hdl.handle.net/10183/115588
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Melbourne
22.
KLASSEN, KAREN.
Vitamin D and HIV: exploring determinants of 25-hydroxyvitamin D and altered vitamin D metabolism in HIV-infected adults.
Degree: 2015, University of Melbourne
URL: http://hdl.handle.net/11343/56389
► Background: Vitamin D deficiency is a widespread global problem of particular importance for people with HIV. Vitamin D is an important hormone for endocrine and…
(more)
▼ Background:
Vitamin D deficiency is a widespread global problem of particular importance for people with HIV. Vitamin D is an important hormone for endocrine and extra-endocrine functions, including modulating the immune system. Vitamin D deficiency is associated with reduced bone mineral density and infectious diseases, both common in people with HIV. Maintaining optimal vitamin D levels may help to reduce the risk of developing these diseases.
The overall research questions for this thesis are: Firstly, which factors influence vitamin D metabolites, and secondly, what effect does vitamin D status have on bone and immunological outcomes, in people living with HIV infection?
Method:
To answer these questions, five studies were performed:
1. Cross-sectional comparison of 25(OH)D levels in HIV-infected and uninfected individuals in southern Australia.
2. Cross-sectional analysis of the determinants of 25(OH)D in people with HIV in Queensland and Melbourne, Australia.
3. Cross-sectional analysis of parathyroid hormone levels in antiretroviral-treated individuals.
4. Cross-sectional analysis of the effect of 25(OH)D on bone mineral density in antiretroviral-treated individuals.
5. Longitudinal analysis of CD4 cell count trajectory in antiretroviral-untreated individuals.
Results:
1. People with HIV were more likely to be vitamin D deficient when compared with people without HIV in southern Australia.
2. Determinants of 25(OH)D levels:
a. UV index and location are important determinants of 25(OH)D levels in people with HIV in Australia.
b. Antiretroviral therapy impacts 25(OH)D levels:
i. Efavirenz is associated with lower 25(OH)D levels, particularly in those with dyslipidaemia.
ii. Protease inhibitors are associated with higher 25(OH)D levels.
3. The effect of tenofovir on parathyroid hormone levels depends on sex and ethnicity; parathyroid hormone levels were higher in non-white males using tenofovir.
4. Influence of ART and 25(OH)D on 1,25(OH)2D levels and bone mineral density:
a. People using tenofovir have higher 1,25(OH)2D levels and people using protease inhibitors have lower 1,25(OH)2D levels.
b. There is an interaction between tenofovir and 25(OH)D status on 1,25(OH)2D levels and bone mineral density. Vitamin D deficiency increases the odds of low bone mineral density only in those not using tenofovir.
5. Vitamin D deficiency may reduce the time to CD4 decline to <350 cells/μL in people living with HIV and untreated with antiretroviral therapy.
Conclusions:
Traditional risk factors for vitamin D deficiency and bone mineral density appear to be more important than HIV-related factors in people with HIV. In spite of this, antiretroviral therapy clearly alters vitamin D and bone metabolism. Understanding the mechanisms behind these alterations may assist in modifying the negative effects of vitamin D deficiency.
Subjects/Keywords: Human immunodeficiency virus (HIV); 25-hydroxyvitamin D; 1,25-dihydroxyvitamin D; vitamin D; Antiretroviral therapy (ART); bone mineral density (BMD)
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APA (6th Edition):
KLASSEN, K. (2015). Vitamin D and HIV: exploring determinants of 25-hydroxyvitamin D and altered vitamin D metabolism in HIV-infected adults. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/56389
Chicago Manual of Style (16th Edition):
KLASSEN, KAREN. “Vitamin D and HIV: exploring determinants of 25-hydroxyvitamin D and altered vitamin D metabolism in HIV-infected adults.” 2015. Doctoral Dissertation, University of Melbourne. Accessed March 06, 2021.
http://hdl.handle.net/11343/56389.
MLA Handbook (7th Edition):
KLASSEN, KAREN. “Vitamin D and HIV: exploring determinants of 25-hydroxyvitamin D and altered vitamin D metabolism in HIV-infected adults.” 2015. Web. 06 Mar 2021.
Vancouver:
KLASSEN K. Vitamin D and HIV: exploring determinants of 25-hydroxyvitamin D and altered vitamin D metabolism in HIV-infected adults. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/11343/56389.
Council of Science Editors:
KLASSEN K. Vitamin D and HIV: exploring determinants of 25-hydroxyvitamin D and altered vitamin D metabolism in HIV-infected adults. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/56389
University of Oulu
23.
Palaniswamy, S. (Saranya).
Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study.
Degree: 2018, University of Oulu
URL: http://urn.fi/urn:isbn:9789526219295
► Abstract Vitamin D deficiency, obesity and short telomere length are reported to be associated with increased risk of metabolic diseases and all-cause mortality, through modulation…
(more)
▼ Abstract
Vitamin D deficiency, obesity and short telomere length are reported to be associated with increased risk of metabolic diseases and all-cause mortality, through modulation of inflammatory pathways. The season of blood sampling, obesity and physical activity have been identified as determinants of 25-hydroxyvitamin D [25(OH)D], but their association with 25(OH)D2 (D2) and 25(OH)D3 (D3) is still poorly understood. In addition, relationships between 25(OH)D, body mass index (BMI), inflammation, and leukocyte telomere length (LTL) has not been previously established. A better understanding of the determinants, risk factors of vitamin D deficiency, and their relationship with BMI, inflammation, and LTL is needed.
The study was based on the 31-year follow-up study of the Northern Finland Birth Cohort 1966 (N=4,758). Statistical analyses were used to 1) examine potential determinants of D2 and D3, and identify risk factors associated with hypovitaminosis D, 2) investigate the relationship of 25(OH)D and BMI with LTL and test whether it is independent of inflammatory pathways and, 3) assess how the association of BMI with inflammatory biomarkers might be mediated through 25(OH)D.
Our results showed that D2 contributed 5% and D3 95% of the total 25(OH)D concentrations. When examined, the determinants for each isoform, periods of low sunlight exposure associated with increased D2, but with decreased D3. Oral contraceptives associated with increased concentrations of both. We confirmed the known risk factors of low vitamin D: low sunlight periods, residing in northern latitudes, and physical inactivity. Serum 25(OH)D was not an important determinant of LTL, and inflammation may partly mediate the BMI-LTL association. Higher serum 25(OH)D was inversely associated with inflammatory biomarkers, and the association between BMI and biomarkers was modestly mediated through lowered 25(OH)D.
In conclusion, our results support the role of known risk factors in vitamin D deficiency and add information on specific determinants of D2 and D3. 25(OH)D did not associate with LTL in young adulthood. We have also provided new insights into a plausible role of vitamin D in BMI associated inflammation. An improved understanding of the role of vitamin D benefits public health in many ways (it can help prevent vitamin D deficiency by implementing lifestyle modification and supplementation).
Tiivistelmä
D-vitamiinin puutos, lihavuus ja lyhyt telomeerien pituus liittyvät mahdollisesti lisääntyneeseen riskiin sairastua metabolisiin sairauksiin sekä yleisemmin kuolleisuuteen. Eräs selitys tälle voi löytyä tulehdustekijöistä. Lihavuuden, liikunnan puutteen ja verinäytteenoton ajankohdan tiedetään vaikuttavan 25-hydroksi-D-vitamiinin [25(OH)D]-pitoisuuteen, mutta niiden yhteys D-vitamiinin isomuotoihin (D2, D3) on vielä huonosti tunnettu. Aiemmin ei ole selvitetty 25(OH)D:n, painoindeksin (BMI), tulehduksen ja leukosyyttien telomeerien pituuden (LTL) välisiä yhteyksiä, ja siksi näistä tarvitaan lisätutkimusta.
Tutkimusaineistona oli…
Advisors/Committee Members: Järvelin, M. (Marjo-Riitta), Sebert, S. (Sylvain).
Subjects/Keywords: 25-hydroxyvitamin D; cytokines; determinants; inflammation; leukocyte telomere length; obesity; risk factors; vitamin D; D-vitamiini; leukosyyttien telomeereiden pituus; liikalihavuus; määräävät tekijät; riskitekijät; sytokiinit; tulehdus; 25(OH)D; NFBC1966
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APA ·
Chicago ·
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CSE |
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APA (6th Edition):
Palaniswamy, S. (. (2018). Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789526219295
Chicago Manual of Style (16th Edition):
Palaniswamy, S (Saranya). “Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study.” 2018. Doctoral Dissertation, University of Oulu. Accessed March 06, 2021.
http://urn.fi/urn:isbn:9789526219295.
MLA Handbook (7th Edition):
Palaniswamy, S (Saranya). “Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study.” 2018. Web. 06 Mar 2021.
Vancouver:
Palaniswamy S(. Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study. [Internet] [Doctoral dissertation]. University of Oulu; 2018. [cited 2021 Mar 06].
Available from: http://urn.fi/urn:isbn:9789526219295.
Council of Science Editors:
Palaniswamy S(. Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study. [Doctoral Dissertation]. University of Oulu; 2018. Available from: http://urn.fi/urn:isbn:9789526219295
University of Oulu
24.
Elkhwanky, M. S. (Mahmoud Sobhy).
Regulation of vitamin D metabolism by metabolic state in mice and humans:discovery of molecular factors repressing vitamin D bioactivation and inducing deficiency in diabetes.
Degree: 2020, University of Oulu
URL: http://urn.fi/urn:isbn:9789526226422
► Abstract Vitamin D deficiency, i.e., low circulating 25-hydroxyvitamin D (25(OH)D) level, has been consistently associated with the prevalence of metabolic diseases, including types 1 and…
(more)
▼ Abstract
Vitamin D deficiency, i.e., low circulating 25-hydroxyvitamin D (25(OH)D) level, has been consistently associated with the prevalence of metabolic diseases, including types 1 and 2 diabetes. However, the causal link between low vitamin D and metabolic disturbances remains uncertain.
In the present thesis, I report novel findings indicating that vitamin D metabolism is under strict control by the metabolic state. Specifically, obesity represses the expression of cytochrome P450 (CYP) 2R1, the major vitamin D 25-hydroxylase responsible for the first bioactivation step in both mice and humans. Interestingly, in humans, weight loss induced by gastric bypass surgery increased CYP2R1 expression in the white adipose tissue.
In mouse liver, Cyp2r1 and vitamin D bioactivation was suppressed by fasting, and both type 1 and type 2 diabetes. This may consequently cause low plasma 25(OH)D levels. On the other hand, fasting induced expression of the vitamin D catabolic enzyme CYP24A1 in the kidney.
Mechanistically, we discovered that Cyp2r1 and vitamin D bioactivation are repressed by molecular pathways activated physiologically by fasting or pathologically in diabetes, namely, the peroxisome proliferator-activated receptor-gamma coactivator 1-α and estrogen-related receptor α (PGC-1α-ERRα), and the glucocorticoid receptor pathways. Moreover, the PGC-1α-ERRα pathway is crucial for mediating the Cyp24a1 induction by fasting in the kidney.
In the current thesis, we uncover a molecular mechanism for the vitamin D deficiency observed in diabetic patients and reveal a novel negative feedback mechanism controlling the crosstalk between energy homeostasis and the vitamin D pathway. Importantly, our data propose that vitamin D deficiency is a consequence, and not the cause of diabetes.
Tiivistelmä
D-vitamiinin puutteen eli veren matalan 25-hydroksi-D-vitamiinin (25(OH)D) pitoisuuden on havaittu toistuvasti assosioituvan metabolisten sairauksien, kuten tyypin 1 ja 2 diabeteksen, ilmenemiseen. Tästä huolimatta D-vitamiinin puutteen ja metabolisten häiriöiden välinen kausaalinen yhteys on epävarma.
Tässä väitöskirjatyössä raportoimme uusia löydöksiä, jotka osoittavat elimistön metabolisen tilan tehokkaasti säätelevän D-vitamiinin aineenvaihduntaa. Tarkemmin ottaen lihavuus repressoi sytokromi P450 (CYP) 2R1:ta, D-vitamiinin tärkeintä 25-hydroksylaasia ja ensimmäistä bioaktivaatiovaihetta sekä hiirissä että ihmisissä. Mielenkiintoinen havainto oli, että ihmisillä mahalaukun ohitusleikkaukseen liittyvä painonlasku sai aikaan CYP2R1:n ilmenemisen nousun valkeassa rasvakudoksessa. Hiiren maksassa sekä tyypin 1 ja 2 diabetes että paastoaminen vähensivät Cyp2r1:n ilmentymistä ja D-vitamiinin bioaktivaatiota. Tämä voi johtaa plasman 25(OH)D pitoisuuden alentumiseen. Toisaalta paastoaminen indusoi D-vitamiinin kataboliaentsyymiä, CYP24A1, munuaisessa.
Mekanistisella tasolla havaitsimme, että Cyp2r1 ilmentymistä ja D-vitamiinin bioaktivaatiota estävät sellaiset molekylaariset säätelytiet, jotka aktivoituvat…
Advisors/Committee Members: Hakkola, J. (Jukka).
Subjects/Keywords: 25-hydroxyvitamin D; adipose tissue; diabetes; human; liver; mice; obesity; vitamin D; 25-hydroksi-D-vitamiini; D-vitamiini; diabetes; lihavuus; maksa; CYP24A1; CYP2R1; GR; PGC-1α
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APA ·
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MLA ·
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APA (6th Edition):
Elkhwanky, M. S. (. S. (2020). Regulation of vitamin D metabolism by metabolic state in mice and humans:discovery of molecular factors repressing vitamin D bioactivation and inducing deficiency in diabetes. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789526226422
Chicago Manual of Style (16th Edition):
Elkhwanky, M S (Mahmoud Sobhy). “Regulation of vitamin D metabolism by metabolic state in mice and humans:discovery of molecular factors repressing vitamin D bioactivation and inducing deficiency in diabetes.” 2020. Doctoral Dissertation, University of Oulu. Accessed March 06, 2021.
http://urn.fi/urn:isbn:9789526226422.
MLA Handbook (7th Edition):
Elkhwanky, M S (Mahmoud Sobhy). “Regulation of vitamin D metabolism by metabolic state in mice and humans:discovery of molecular factors repressing vitamin D bioactivation and inducing deficiency in diabetes.” 2020. Web. 06 Mar 2021.
Vancouver:
Elkhwanky MS(S. Regulation of vitamin D metabolism by metabolic state in mice and humans:discovery of molecular factors repressing vitamin D bioactivation and inducing deficiency in diabetes. [Internet] [Doctoral dissertation]. University of Oulu; 2020. [cited 2021 Mar 06].
Available from: http://urn.fi/urn:isbn:9789526226422.
Council of Science Editors:
Elkhwanky MS(S. Regulation of vitamin D metabolism by metabolic state in mice and humans:discovery of molecular factors repressing vitamin D bioactivation and inducing deficiency in diabetes. [Doctoral Dissertation]. University of Oulu; 2020. Available from: http://urn.fi/urn:isbn:9789526226422
McMaster University
25.
Science, Michelle.
Vitamin D and Respiratory Tract Infections (RTIs): The Impact of Vitamin D on the Risk and Severity of Upper RTIs and the Role of Vitamin D in Influenza Vaccine Immunogenicity in Children.
Degree: MSc, 2012, McMaster University
URL: http://hdl.handle.net/11375/15249
► Recent evidence suggests that vitamin D may be important for immune function. Canadian studies have reported varying prevalences of low levels of vitamin D.…
(more)
▼ Recent evidence suggests that vitamin D may be important for immune function. Canadian studies have reported varying prevalences of low levels of vitamin D. Whether these low vitamin D levels are associated with susceptibility to respiratory tract infections (RTIs) and infection severity remains unclear given the inconsistent association in recent studies. Influenza virus as a cause of RTI is of particular interest given its prevalence, morbidity and economic burden. Vaccination is a key strategy in prevention, but little is known about the effect of vitamin D on influenza vaccine response. A prospective cohort study of children 3 to 15 years old living in Hutterite communities in Alberta, Saskatchewan and Manitoba was conducted to assess the prevalence and predictors of low vitamin D levels and evaluate the association between vitamin D and the incidence and severity of laboratory proven respiratory tract infections. In those who received influenza vaccination, the relationship between vitamin D and influenza vaccine immunogenicity was examined. A total of 743 children were included in the study. The median serum 25-hydroxyvitamin D level (25[OH]D) was 62.0 nmol/L (interquartile range 51.0, 74.0). Levels lower than 50 nmol/L were present in 152 children (20.5%) and lower than 75 nmol/L in 565 children (76%). Lower serum 25(OH)D levels were associated with increased risk of RTI. No association was found between serum 25(OH)D level and disease severity. There was also no relationship found between serum 25(OH)D level and seroprotection or seroconversion from inactivated influenza vaccine. In conclusion, low serum 25(OH)D levels are a significant problem in Canadian Hutterite communities. Furthermore, low serum 25(OH)D levels were associated with increased risk of proven upper RTIs. Studies evaluating the role of vitamin D supplementation to reduce the burden of disease are warranted, and strategies to improve vitamin D status in rural communities in Canada are needed.
Master of Science (MSc)
Advisors/Committee Members: Loeb, Mark, Walter, Stephen, Smieja, Marek, Health Research Methodology.
Subjects/Keywords: Vitamin D; Serum 25-hydroxyvitamin D; Respiratory tract infection; influenza vaccine; Hutterite communities; Infectious Disease; Infectious Disease
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APA ·
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APA (6th Edition):
Science, M. (2012). Vitamin D and Respiratory Tract Infections (RTIs): The Impact of Vitamin D on the Risk and Severity of Upper RTIs and the Role of Vitamin D in Influenza Vaccine Immunogenicity in Children. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/15249
Chicago Manual of Style (16th Edition):
Science, Michelle. “Vitamin D and Respiratory Tract Infections (RTIs): The Impact of Vitamin D on the Risk and Severity of Upper RTIs and the Role of Vitamin D in Influenza Vaccine Immunogenicity in Children.” 2012. Masters Thesis, McMaster University. Accessed March 06, 2021.
http://hdl.handle.net/11375/15249.
MLA Handbook (7th Edition):
Science, Michelle. “Vitamin D and Respiratory Tract Infections (RTIs): The Impact of Vitamin D on the Risk and Severity of Upper RTIs and the Role of Vitamin D in Influenza Vaccine Immunogenicity in Children.” 2012. Web. 06 Mar 2021.
Vancouver:
Science M. Vitamin D and Respiratory Tract Infections (RTIs): The Impact of Vitamin D on the Risk and Severity of Upper RTIs and the Role of Vitamin D in Influenza Vaccine Immunogenicity in Children. [Internet] [Masters thesis]. McMaster University; 2012. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/11375/15249.
Council of Science Editors:
Science M. Vitamin D and Respiratory Tract Infections (RTIs): The Impact of Vitamin D on the Risk and Severity of Upper RTIs and the Role of Vitamin D in Influenza Vaccine Immunogenicity in Children. [Masters Thesis]. McMaster University; 2012. Available from: http://hdl.handle.net/11375/15249
26.
최, 승화.
Comparison on metabolic markers and hormone level according to serum 25-hydroxyvitamin D level.
Degree: 2007, Ajou University
URL: http://repository.ajou.ac.kr/handle/201003/1684
;
http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002639
► OBJECT: Vitamin D have diverse effects on various metabolic markers and hormone. We investigated multiple roles of vitamin D by comparing metabolic markers and hormone…
(more)
▼ OBJECT: Vitamin D have diverse effects on various metabolic markers and hormone. We investigated multiple roles of vitamin D by comparing metabolic markers and hormone levels according to serum 25-hydroxyvitamin D level.
METHODS: We investigated 3,399 women who had periodic health examination in Ajou university hospital from March 1st, 1997 to February 28th, 2005. Height, Weight, Waist circumference, and blood pressure were measured. Socioeconomic status was asked by questionnaire. Serum 25-hydroxyvitamin D level, fasting glucose, uric acid, albumin, lipid profile, high sensitive C-reactive protein, homocysteine and white blood cell counts were measured. Insulin like growth factor-I, insulin like growth factor binding protein 3, and sex hormone binding globulin level were measured. We divide the subjects into noraml vitamin D group and vitamin D deficiency group by serum 25-hydroxyvitamin level 20 ng/ml.
RESULTS: Mean age was older in normal vitamin D group than in vitamin deficiency group with significance(P=0.042). Activity was significantly different between normal vitamin D group and vitamin deficiency group(P=0.001). Education level and financial state were not different between normal vitamin D group and vitamin D deficiency group. Body mass index and body fat were significantly lower in normal vitamin D group(P=0.012, P=0.001). Lean body mass was significantly higher in normal vitamin D group than in vitamin D deficiency group(P=0.004). Systolic blood pressure was significantly higher in normal vitamin D group than in vitamin D deficiency group after age adjustment(P=0.041). Uric acid level was significantly higher in normal vitamin D group(P=0.018). Fasting glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and serum albumin level were not different between normal vitamin D group and vitamin D deficiency group. White blood cell counts, high sensitivity C-reactive protein, and homocysteine level were not different between normal vitamin D group and vitamin D deficiency group. Insulin growth factor-I level was significantly higher in normal vitamin D group than in vitamin D deficiency group after age adjustment(P=0.013). Insulin like growth factor binding protein 3 level was significantly higher in normal vitamin D group(P=0.001). Sex hormone binding globulin level was not different between normal vitamin D group and vitamin D deficiency group.
CONCLUSION: Vitamin D has some effects on metabolism and hormone secretion. If more investigations about multiple roles of vitamin D were done, we could anticipate wide use of vitamin D for not only bone metabolism but also metabolism and hormone secretion.
연구목적: 골대사와 관련된 부분 이외의 비타민 D의 역할에 대해 다양한 연구가 이뤄지고 있으나 우리나라에서의 자료는 부족한 실정이다. 이 연구에서는 한국인 여성을 대상으로, 혈청 25(OH) 비타민 D농도 20ng/ml를 기준으로 하여 정상 비타민 D군과 비타민 D 부족군으로 나누어, 두 군 간의 대사지표 및 호르몬수치의 비교를 통해 비타민 D의 다양한 역할에 대해 알아보고자 하였다.
연구대상 및 방법: 1997년 3월 1일부터 2005년 2월 28일까지 아주대학병원 건강검진센터를 내원하여 건강검진을 받은 30세 이상의 여성 중 혈청 25(OH) 비타민 D농도를 측정한 3,399명을 대상으로, 인구사회학적 특성을 설문조사…
Advisors/Committee Members: 대학원 의학과, 200424210, 최, 승화.
Subjects/Keywords: 비타민 D; 대사지표; 호르몬; 25-hydroxyvitamin D; metabolic markers
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APA (6th Edition):
최, . (2007). Comparison on metabolic markers and hormone level according to serum 25-hydroxyvitamin D level. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/1684 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002639
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
최, 승화. “Comparison on metabolic markers and hormone level according to serum 25-hydroxyvitamin D level.” 2007. Thesis, Ajou University. Accessed March 06, 2021.
http://repository.ajou.ac.kr/handle/201003/1684 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002639.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
최, 승화. “Comparison on metabolic markers and hormone level according to serum 25-hydroxyvitamin D level.” 2007. Web. 06 Mar 2021.
Vancouver:
최 . Comparison on metabolic markers and hormone level according to serum 25-hydroxyvitamin D level. [Internet] [Thesis]. Ajou University; 2007. [cited 2021 Mar 06].
Available from: http://repository.ajou.ac.kr/handle/201003/1684 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002639.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
최 . Comparison on metabolic markers and hormone level according to serum 25-hydroxyvitamin D level. [Thesis]. Ajou University; 2007. Available from: http://repository.ajou.ac.kr/handle/201003/1684 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002639
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Maryland
27.
Verdin, Kelly.
Association Between C-Reactive Protein and Serum 25-Hydroxyvitamin D: A Negative Acute Phase Reactant.
Degree: Epidemiology and Biostatistics, 2015, University of Maryland
URL: http://hdl.handle.net/1903/16784
► Objective: The aims of this study were to determine whether serum 25-hydroxyvitamin-D (25-OH-vitamin D) is a negative acute phase reactant and whether class of diagnosis…
(more)
▼ Objective: The aims of this study were to determine whether serum
25-
hydroxyvitamin-
D (
25-OH-vitamin
D) is a negative acute phase reactant and whether class of diagnosis modifies the association between C-Reactive Protein (CRP) and
25-OH-vitamin
D.
Methods: Multiple linear regression analysis was utilized to assess the association between CRP and
25-OH-vitamin
D in 1,043 patients with acute and chronic diseases and normal volunteers.
Results: After adjusting for confounding factors, the association between CRP and
25-OH-vitamin
D was statistically significant. Class of diagnosis did not modify this association.
Conclusions:
25-OH-vitamin
D is demonstrated to be a negative acute phase reactant in this group of patients; Therefore, it is not an accurate marker of vitamin
D status in the setting of inflammation. These findings support that
25-OH-vitamin
D should be interpreted cautiously when CRP is elevated and that evaluating
25-OH-vitamin
D in the context of CRP will improve accuracy of
25-OH-vitamin
D interpretation.
Advisors/Committee Members: Lee, Sunmin (advisor).
Subjects/Keywords: Epidemiology; Nutrition; Public health; 25-hydroxyvitamin D; C-reactive protein; Inflammation; Negative acute phase reactant; Vitamin D
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APA ·
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Manager
APA (6th Edition):
Verdin, K. (2015). Association Between C-Reactive Protein and Serum 25-Hydroxyvitamin D: A Negative Acute Phase Reactant. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/16784
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Verdin, Kelly. “Association Between C-Reactive Protein and Serum 25-Hydroxyvitamin D: A Negative Acute Phase Reactant.” 2015. Thesis, University of Maryland. Accessed March 06, 2021.
http://hdl.handle.net/1903/16784.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Verdin, Kelly. “Association Between C-Reactive Protein and Serum 25-Hydroxyvitamin D: A Negative Acute Phase Reactant.” 2015. Web. 06 Mar 2021.
Vancouver:
Verdin K. Association Between C-Reactive Protein and Serum 25-Hydroxyvitamin D: A Negative Acute Phase Reactant. [Internet] [Thesis]. University of Maryland; 2015. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1903/16784.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Verdin K. Association Between C-Reactive Protein and Serum 25-Hydroxyvitamin D: A Negative Acute Phase Reactant. [Thesis]. University of Maryland; 2015. Available from: http://hdl.handle.net/1903/16784
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
28.
Purdue-Smithe, Alexandra.
Predicted 25-hydroxyvitamin D Score and Risk of Multiple Sclerosis in U.S. Women.
Degree: University of Massachusetts
URL: https://scholarworks.umass.edu/masters_theses_2/235
► Multiple sclerosis (MS) is a progressive, autoimmune neurodegenerative disorder affecting nearly 350,000 people in the United States and resulting in significant disability. As an…
(more)
▼ Multiple sclerosis (MS) is a progressive, autoimmune neurodegenerative disorder affecting nearly 350,000 people in the United States and resulting in significant disability. As an immunomodulator, vitamin
D may play a role in the development of MS. Previous studies have observed an inverse association of
25-
hydroxyvitamin D (
25(OH)
D) levels and MS risk in younger populations; however, whether this relationship persists in older adults remains unclear. We prospectively investigated the association between predicted
25(OH)
D level and incident MS in the Nurses’ Health Study (NHS) (n=121,701) and NHS II (n=116,430).
25(OH)
D levels were predicted using validated regression models that include important determinants of vitamin
D status, including race, UV-B flux (based on state of residence), physical activity, body mass index, dietary vitamin
D intake, alcohol consumption and post-menopausal hormone use. Data on these factors were self-reported on NHS and NHS II questionnaires starting in 1986 and 1991, respectively, and updated every 2-4 years. MS diagnoses were ascertained by self-report and confirmed by medical records. Cox proportional hazards models adjusted for age, ethnicity, latitude of residence at age 15, and BMI at age 18 were used to estimate hazard ratios (HR)s and 95% confidence intervals (CI)s in each cohort. During up to 18 years of follow-up, we documented 179 definite/probable cases of MS with first symptoms after baseline. Multivariable HRs comparing highest and lowest quintiles of predicted
25(OH)
D were 1.09 (95% CI: 0.40-2.96) in the NHS and 0.52 (95% CI: 0.28-0.95) in the NHS II. Higher predicted plasma
25(OH)
D may be modestly associated with lower risk of MS, primarily in younger women.
Advisors/Committee Members: Elizabeth R Bertone-Johnson, Susan E Hankinson.
Subjects/Keywords: multiple sclerosis; predicted 25-hydroxyvitamin D; vitamin D
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APA ·
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APA (6th Edition):
Purdue-Smithe, A. (n.d.). Predicted 25-hydroxyvitamin D Score and Risk of Multiple Sclerosis in U.S. Women. (Thesis). University of Massachusetts. Retrieved from https://scholarworks.umass.edu/masters_theses_2/235
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Purdue-Smithe, Alexandra. “Predicted 25-hydroxyvitamin D Score and Risk of Multiple Sclerosis in U.S. Women.” Thesis, University of Massachusetts. Accessed March 06, 2021.
https://scholarworks.umass.edu/masters_theses_2/235.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Purdue-Smithe, Alexandra. “Predicted 25-hydroxyvitamin D Score and Risk of Multiple Sclerosis in U.S. Women.” Web. 06 Mar 2021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Purdue-Smithe A. Predicted 25-hydroxyvitamin D Score and Risk of Multiple Sclerosis in U.S. Women. [Internet] [Thesis]. University of Massachusetts; [cited 2021 Mar 06].
Available from: https://scholarworks.umass.edu/masters_theses_2/235.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
Purdue-Smithe A. Predicted 25-hydroxyvitamin D Score and Risk of Multiple Sclerosis in U.S. Women. [Thesis]. University of Massachusetts; Available from: https://scholarworks.umass.edu/masters_theses_2/235
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
RMIT University
29.
Al Bahrani, A.
A novel simultaneous quantification method for fat-soluble vitamins using liquid chromatography-tandem mass spectrometry for clinical applications.
Degree: 2015, RMIT University
URL: http://researchbank.rmit.edu.au/view/rmit:161417
► The accurate and precise quantification of fat-soluble vitamins (FSVs), specifically vitamins A, D and E, has proved to be a challenge for clinical laboratories. This…
(more)
▼ The accurate and precise quantification of fat-soluble vitamins (FSVs), specifically vitamins A, D and E, has proved to be a challenge for clinical laboratories. This challenge is partially the result of the nature of FSV molecules and the limitations in techniques commonly used in their analysis. Consequently, there is a variation in the results obtained through different techniques or by different clinical laboratories. As a result, it has been difficult to reach agreement on the recommended levels or reference intervals of these vitamins. The current project encompassed the development of a state-of-the-art analytical method for the analysis of vitamins A (retinol), D (25-hydroxyvitamin D [25-OHD]) and E (α-tocopherol) in blood using liquid chromatography-tandem mass spectrometry (LC-MS/MS), which is a highly sensitive and specific quantification technique. Four studies were then performed to explore several scientific knowledge gaps related to vitamin measurement using the developed FSV quantification methods. The Current translational clinical research introduced novel and precise simultaneous measurement methods for blood FSV analytes, which were applicability to clinical sampling trials. This thesis also provides the first study exploring the stability FSVs simultaneously in routine sample spectrum utilising a precise LC-MS/MS method. In addition, stability of each analytes is justified based on calculation of the acceptable clinical limits, which reflect biological variation as well as method imprecision. This project also highlighted problematic issue related to trueness and reliable traceability of commercial calibrators to high order references and that interrupts effort of method harmonisation and patient result comparability. Furthermore, the current thesis provides with first study validated the measurement of 25-OHD3 and retinol in UCB diluted plasma. Lastly, this thesis reports the first study exploring status of five FSV analytes in two Australian populations at different latitudes using simultaneous measurement LC-MS/MS method. Furthermore, this is the first work examined the correlation between the blood FSV levels in two Australian populations.
Subjects/Keywords: Fields of Research; Fat-soluble vitamins; 25-Hydroxyvitamin D; Retinol; Tocopherol; Liquid chromatography-tandem mass spectrometry; Quantification method
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APA ·
Chicago ·
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CSE |
Export
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Manager
APA (6th Edition):
Al Bahrani, A. (2015). A novel simultaneous quantification method for fat-soluble vitamins using liquid chromatography-tandem mass spectrometry for clinical applications. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:161417
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Al Bahrani, A. “A novel simultaneous quantification method for fat-soluble vitamins using liquid chromatography-tandem mass spectrometry for clinical applications.” 2015. Thesis, RMIT University. Accessed March 06, 2021.
http://researchbank.rmit.edu.au/view/rmit:161417.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Al Bahrani, A. “A novel simultaneous quantification method for fat-soluble vitamins using liquid chromatography-tandem mass spectrometry for clinical applications.” 2015. Web. 06 Mar 2021.
Vancouver:
Al Bahrani A. A novel simultaneous quantification method for fat-soluble vitamins using liquid chromatography-tandem mass spectrometry for clinical applications. [Internet] [Thesis]. RMIT University; 2015. [cited 2021 Mar 06].
Available from: http://researchbank.rmit.edu.au/view/rmit:161417.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Al Bahrani A. A novel simultaneous quantification method for fat-soluble vitamins using liquid chromatography-tandem mass spectrometry for clinical applications. [Thesis]. RMIT University; 2015. Available from: http://researchbank.rmit.edu.au/view/rmit:161417
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Urbana-Champaign
30.
Watson, Megan.
Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus) and rabbits (Oryctolagus cuniculus).
Degree: MS, 0359, 2014, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/50499
► Vitamin D is an important hormone in vertebrates. Most animals acquire this hormone through their diet, exposure to ultraviolet B (UVB) radiation and subsequent photobiochemical…
(more)
▼ Vitamin
D is an important hormone in vertebrates. Most animals acquire this hormone through their diet, exposure to ultraviolet B (UVB) radiation and subsequent photobiochemical synthesis, or a combination thereof. The objectives for this research were to evaluate the clinical and physiologic effects of artificial UVB light supplementation on rabbits (Oryctolagus cuniculus) and guinea pigs (Cavia porcellus) and to evaluate the long-term safety of artificial UVB light supplementation over the course of six months in these species. Twelve juvenile acromelanic albino Hartley guinea pigs and twelve juvenile New Zealand white rabbits were randomly assigned to one of two treatment groups: Group A was exposed to 12 hours of artificial UVB radiation daily and Group B received ambient fluorescent light with no UVB supplementation for 12 hours daily. Animals in both groups were offered the same diet and housed under the same conditions. Blood samples were collected every three weeks over six months to measure blood chemistry values, parathyroid hormone, ionized calcium, and serum
25-
hydroxyvitamin D3 (
25-OHD3) levels. Serial ophthalmologic examinations were performed at the beginning of the study and every two months thereafter. Computed tomography (CT) scans were performed at beginning and conclusion of the study to assess bone mineral density. Dual energy x-ray absorptiometry (DEXA) scans were performed at the conclusion of the study. At the end of the study the animals were euthanized and necropsied. Mean ± SD serum
25-OHD3 concentrations differed significantly in both the guinea pigs (p < 0.0001) and rabbits (p= 0.003) between animals provided supplemental UVB radiation (Guinea pig: 101.49 ± 21.81 nmol/L; Rabbit: 83.12 ± 22.44 nmol/L) and those not provided supplemental UVB radiation (Guinea pig: 36.33 ± 24.42 nmol/L; Rabbit: 39.33± 26.07 nmol/L). No significant difference in bone mineral density was noted between groups on CT scans or the DEXA scan. An increased corneal thickness in both eyes was found in guinea pigs supplemented with UVB compared to those provided ambient light (right eye [OD]: F=149.527, p<0.0001; left eye [OS]: F=30.525, p=<0.0001). There were no apparent negative clinical or pathologic side effects noted between the treatment and control animals. This study found that exposing guinea pigs and rabbits to UVB radiation long term significantly increased their circulating serum
25-OHD3 levels, and that this increase was sustainable over time. In vertebrates, vitamin
D is an essential hormone that regulates many different functions in the body and can be protective against various disease conditions. Providing guinea pigs, rabbits, or other diurnal rodents, exposure to UVB may be an important husbandry consideration that is not currently recommended.
Advisors/Committee Members: Mitchell, Mark A. (advisor).
Subjects/Keywords: Vitamin D; 25-hydroxyvitamin D3; ultraviolet B radiation; ultraviolet B (UVB); rabbit; Oryctolagus cuniculus; guinea pig; Cavia porcellus
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APA ·
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CSE |
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Manager
APA (6th Edition):
Watson, M. (2014). Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus) and rabbits (Oryctolagus cuniculus). (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/50499
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Watson, Megan. “Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus) and rabbits (Oryctolagus cuniculus).” 2014. Thesis, University of Illinois – Urbana-Champaign. Accessed March 06, 2021.
http://hdl.handle.net/2142/50499.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Watson, Megan. “Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus) and rabbits (Oryctolagus cuniculus).” 2014. Web. 06 Mar 2021.
Vancouver:
Watson M. Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus) and rabbits (Oryctolagus cuniculus). [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2014. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/2142/50499.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Watson M. Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus) and rabbits (Oryctolagus cuniculus). [Thesis]. University of Illinois – Urbana-Champaign; 2014. Available from: http://hdl.handle.net/2142/50499
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
◁ [1] [2] ▶
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Open Access Theses and Dissertations
