subject:(19F NMR)

University of Manchester

1. Mistry, Jinesh. SYNTHESIS AND CONFORMATIONAL ANALYSIS OF POLYARENE DENDRIMERS.

Degree: 2016, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:297844

► Polyarene dendrimers with rigid aromatic regions are of interest due to their shape persistentnature.A novel series of G1 dendrimers containing a substituted 1,3-phenyl core are… (more)

Subjects/Keywords: Dendrimer; atropisomer; 19F NMR

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APA (6^th Edition):

Mistry, J. (2016). SYNTHESIS AND CONFORMATIONAL ANALYSIS OF POLYARENE DENDRIMERS. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:297844

Chicago Manual of Style (16^th Edition):

Mistry, Jinesh. “SYNTHESIS AND CONFORMATIONAL ANALYSIS OF POLYARENE DENDRIMERS.” 2016. Doctoral Dissertation, University of Manchester. Accessed February 25, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:297844.

MLA Handbook (7^th Edition):

Mistry, Jinesh. “SYNTHESIS AND CONFORMATIONAL ANALYSIS OF POLYARENE DENDRIMERS.” 2016. Web. 25 Feb 2021.

Vancouver:

Mistry J. SYNTHESIS AND CONFORMATIONAL ANALYSIS OF POLYARENE DENDRIMERS. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Feb 25]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:297844.

Council of Science Editors:

Mistry J. SYNTHESIS AND CONFORMATIONAL ANALYSIS OF POLYARENE DENDRIMERS. [Doctoral Dissertation]. University of Manchester; 2016. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:297844

University of Manchester

2. Mistry, Jinesh. Synthesis and conformational analysis of polyarene dendrimers.

Degree: PhD, 2016, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/synthesis-and-conformational-analysis-of-polyarene-dendrimers(650b10eb-6afd-471c-b688-5f86ee65f42c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684791

► Polyarene dendrimers with rigid aromatic regions are of interest due to their shape persistent nature. A novel series of G1 dendrimers containing a substituted 1,3-phenyl… (more)

Subjects/Keywords: 668.9; Dendrimer; atropisomer; 19F NMR

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APA (6^th Edition):

Mistry, J. (2016). Synthesis and conformational analysis of polyarene dendrimers. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/synthesis-and-conformational-analysis-of-polyarene-dendrimers(650b10eb-6afd-471c-b688-5f86ee65f42c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684791

Chicago Manual of Style (16^th Edition):

Mistry, Jinesh. “Synthesis and conformational analysis of polyarene dendrimers.” 2016. Doctoral Dissertation, University of Manchester. Accessed February 25, 2021. https://www.research.manchester.ac.uk/portal/en/theses/synthesis-and-conformational-analysis-of-polyarene-dendrimers(650b10eb-6afd-471c-b688-5f86ee65f42c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684791.

MLA Handbook (7^th Edition):

Mistry, Jinesh. “Synthesis and conformational analysis of polyarene dendrimers.” 2016. Web. 25 Feb 2021.

Vancouver:

Mistry J. Synthesis and conformational analysis of polyarene dendrimers. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Feb 25]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/synthesis-and-conformational-analysis-of-polyarene-dendrimers(650b10eb-6afd-471c-b688-5f86ee65f42c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684791.

Council of Science Editors:

Mistry J. Synthesis and conformational analysis of polyarene dendrimers. [Doctoral Dissertation]. University of Manchester; 2016. Available from: https://www.research.manchester.ac.uk/portal/en/theses/synthesis-and-conformational-analysis-of-polyarene-dendrimers(650b10eb-6afd-471c-b688-5f86ee65f42c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684791

Texas A&M University

3. Pituckchon, Arpajit. Further Investigation of Fluoboric Acid in Sandstone Acidizing Using ^(11)B and ^(19)F NMR.

Degree: MS, Petroleum Engineering, 2014, Texas A&M University

URL: http://hdl.handle.net/1969.1/152823

► Although fluoboric acid (HBF_(4)) has long been known as one of the low-damaging acid treatments for clayey sandstone formations, little is known of its chemistry… (more)

▼ Although fluoboric acid (HBF_(4)) has long been known as one of the low-damaging acid treatments for clayey sandstone formations, little is known of its chemistry which could explain the mixed results of fluoboric acid in actual field application. A better understanding of its limitations would contribute to an improved success rate in HBF_(4) stimulation application. The unique advantages of this acid system are the ability to reach deeper into formation to address damage at extended radius before spending, owing to its slow hydrolytic reaction to produce HF, as well as the stabilization and desensitization of undissolved fines with borosilicate. A more comprehensive understanding of how the chemistry of fluoboric acid and its reaction products affect silica and aluminosilicates is crucial to the design and optimization of fluoboric acidizing treatment. Through a novel application of ^(11)B and ^(19)F Solution State High Field Nuclear Magnetic Resonance (NMR) spectroscopy, chemical complexes involved in the reaction were defined. Various other experimental techniques were also employed in studies on the ability of hydrolyzed fluoboric acid to react with common clays found in sandstone at room and elevated temperatures, as well as coreflooding to investigate clay migration development. Analyzing fresh and spent acid with inductively coupled plasma (ICP) and ^(11)B and ^(19)F NMR helps identify reaction products and their distribution. A set of 12-3 mud acid experiments was done in parallel to serve as a reference to 3%- equivalent-HF fluoboric acid in aqueous-HCl solution. NMR results show complex mixtures of fluoborate species from HBF_(4) hydrolysis and products from HF-aluminosilicates reaction. The fresh HB_(F4) hydrolysis study at room temperature has confirmed retarded HF generation with presence of BF_(4)- and BF_(3)(OH)- and absence of BF_(2)(OH)_(2)- or BF(OH)_(3)- species . The effect of temperature on HBF4 reaction has also been studied to validate functionality of acid at 75°F and 200°F. A series of lab dynamic flow testing in Berea sandstone corroborates conclusions from lab experiments by showing decrease in permeability when treating Berea sandstone cores with HBF_(4) at 200°F. Fluoboric acid treatment is therefore not suitable for formations with approximate temperature of 200°F. Advisors/Committee Members: Nasr-El-Din , Hisham A. (advisor), Barrufet, Maria A. (committee member), El-Halwagi, Mahmoud (committee member).

Subjects/Keywords: fluoboric; sandstone; acidizing; 11B; 19F; NMR; Berea

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APA (6^th Edition):

Pituckchon, A. (2014). Further Investigation of Fluoboric Acid in Sandstone Acidizing Using ^(11)B and ^(19)F NMR. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/152823

Chicago Manual of Style (16^th Edition):

Pituckchon, Arpajit. “Further Investigation of Fluoboric Acid in Sandstone Acidizing Using ^(11)B and ^(19)F NMR.” 2014. Masters Thesis, Texas A&M University. Accessed February 25, 2021. http://hdl.handle.net/1969.1/152823.

MLA Handbook (7^th Edition):

Pituckchon, Arpajit. “Further Investigation of Fluoboric Acid in Sandstone Acidizing Using ^(11)B and ^(19)F NMR.” 2014. Web. 25 Feb 2021.

Vancouver:

Pituckchon A. Further Investigation of Fluoboric Acid in Sandstone Acidizing Using ^(11)B and ^(19)F NMR. [Internet] [Masters thesis]. Texas A&M University; 2014. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1969.1/152823.

Council of Science Editors:

Pituckchon A. Further Investigation of Fluoboric Acid in Sandstone Acidizing Using ^(11)B and ^(19)F NMR. [Masters Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/152823

University of Manchester

4. Moutzouri, Pinelopi. New and improved methods for mixture analysis by NMR.

Degree: 2018, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:316076

► A unique characteristic of NMR is that, unlike other spectroscopic techniques, it separates the excitation of signals from their detection. By manipulating the type of… (more)

Subjects/Keywords: NMR; mixture analysis; Pure shift NMR; DOSY; 13C satellites; 19F NMR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moutzouri, P. (2018). New and improved methods for mixture analysis by NMR. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:316076

Chicago Manual of Style (16^th Edition):

Moutzouri, Pinelopi. “New and improved methods for mixture analysis by NMR.” 2018. Doctoral Dissertation, University of Manchester. Accessed February 25, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:316076.

MLA Handbook (7^th Edition):

Moutzouri, Pinelopi. “New and improved methods for mixture analysis by NMR.” 2018. Web. 25 Feb 2021.

Vancouver:

Moutzouri P. New and improved methods for mixture analysis by NMR. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Feb 25]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:316076.

Council of Science Editors:

Moutzouri P. New and improved methods for mixture analysis by NMR. [Doctoral Dissertation]. University of Manchester; 2018. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:316076

University of Manchester

5. Rasul, Usman Anawar. NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES.

Degree: 2012, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:162954

► The structure, kinetics, and interactions of the conserved 16mer and 15mer RNA motifs of the internal ribosome entry site (IRES) of the Foot-and-Mouth Disease virus… (more)

▼ The structure, kinetics, and interactions of the conserved 16mer and 15mer RNA motifs of the internal ribosome entry site (IRES) of the Foot-and-Mouth Disease virus (FMDV), have been investigated by homonuclear and heteronuclear NMR techniques. The 16mer RNA is endowed with a classic GNRA tetraloop motif, which is essential for IRES activity and the 15mer RNA motif is a potential tetraloop receptor. We have determined three high resolution NMR solution structures of the 16mer apo-RNA, the 16mer Mg2+ RNA complex and the 15mer apo-RNA with RMSDs of 0.17Å, 0.16Å and 0.35Å, respectively. The high precision of these NMR structures was achieved by including a large number of NMR experimental restraints, derived from NOEs and coupling constants, and validating them using the MolProbity program. The 16mer RNA structure comprised of six base pairs with a GUAA tetraloop and the 15mer RNA structure comprised of four base pairs and a large heptaloop; this is the first heptaloop to be studied by NMR.Addition of Mg2+ to the 16mer apo-RNA caused selective chemical shift changes to the stem G177 and loop G178 imino proton resonances, suggesting Mg2+-induced conformational change to the GUAA tetraloop. This was supported by a significant chemical shift change to the selectively 19F-labelled loop U179 in the 5-FU 16mer RNA. Furthermore, variable temperature experiments revealed retarded imino proton exchange for the stem and loop imino protons, demonstrating the enhanced thermodynamic stability conferred by Mg2+. This enhancement in stability was confirmed by measuring the imino proton exchange rates for the 16mer apo-RNA and the 16mer Mg2+ RNA complex. Analysis of the 16mer apo-RNA and its Mg2+ RNA complex NMR solution structures revealed that Mg2+-induced structural changes to the GUAA tetraloop act to stabilise the loop via stronger base stacking and intramolecular interactions. Fascinatingly, we discovered that Mg2+ ions provide increased stability required for the formation of a G.A sheared base pair in the GUAA tetraloop. RNA-RNA interactions between the 16mer and 15mer RNAs and their fluorinated analogues were studied by NMR spectroscopy. Small changes to chemical shift and linewidth of proton peaks in the non-fluorinated RNA-RNA complex provided evidence for a weak interaction between the loop of the 16mer RNA and the stem of the 15mer RNA. 19F-NMR experiments revealed additional peaks for the 19F-labelled U179 of the fluorinated 16mer/15mer RNA complex providing further good evidence of RNA-RNA interaction.The NMR structures of the conserved RNA motifs and their interactions have yielded important information in understanding the properties and behaviour of RNA. This will provide the first stepping stone in understanding the IRES mechanism and its use in antiviral therapy and biotechnology. Advisors/Committee Members: Ramesh, Vasudevan.

Subjects/Keywords: FMDV; IRES; GNRA; RNA; NMR; Mg2+; 19F-NMR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rasul, U. A. (2012). NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:162954

Chicago Manual of Style (16^th Edition):

Rasul, Usman Anawar. “NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES.” 2012. Doctoral Dissertation, University of Manchester. Accessed February 25, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:162954.

MLA Handbook (7^th Edition):

Rasul, Usman Anawar. “NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES.” 2012. Web. 25 Feb 2021.

Vancouver:

Rasul UA. NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Feb 25]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:162954.

Council of Science Editors:

Rasul UA. NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES. [Doctoral Dissertation]. University of Manchester; 2012. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:162954

University of Manchester

6. Rasul, Usman Anawar. NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES.

Degree: PhD, 2012, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/nmr-studies-of-the-structure-kinetics-and-interactions-of-the-conserved-rna-motifs-in-the-fmdv-ires(be21f327-53e1-48aa-bf9c-c4bd2d028417).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554174

► The structure, kinetics, and interactions of the conserved 16mer and 15mer RNA motifs of the internal ribosome entry site (IRES) of the Foot-and-Mouth Disease virus… (more)

▼ The structure, kinetics, and interactions of the conserved 16mer and 15mer RNA motifs of the internal ribosome entry site (IRES) of the Foot-and-Mouth Disease virus (FMDV), have been investigated by homonuclear and heteronuclear NMR techniques. The 16mer RNA is endowed with a classic GNRA tetraloop motif, which is essential for IRES activity and the 15mer RNA motif is a potential tetraloop receptor. We have determined three high resolution NMR solution structures of the 16mer apo-RNA, the 16mer Mg2+ RNA complex and the 15mer apo-RNA with RMSDs of 0.17Å, 0.16Å and 0.35Å, respectively. The high precision of these NMR structures was achieved by including a large number of NMR experimental restraints, derived from NOEs and coupling constants, and validating them using the MolProbity program. The 16mer RNA structure comprised of six base pairs with a GUAA tetraloop and the 15mer RNA structure comprised of four base pairs and a large heptaloop; this is the first heptaloop to be studied by NMR.Addition of Mg2+ to the 16mer apo-RNA caused selective chemical shift changes to the stem G177 and loop G178 imino proton resonances, suggesting Mg2+-induced conformational change to the GUAA tetraloop. This was supported by a significant chemical shift change to the selectively 19F-labelled loop U179 in the 5-FU 16mer RNA. Furthermore, variable temperature experiments revealed retarded imino proton exchange for the stem and loop imino protons, demonstrating the enhanced thermodynamic stability conferred by Mg2+. This enhancement in stability was confirmed by measuring the imino proton exchange rates for the 16mer apo-RNA and the 16mer Mg2+ RNA complex. Analysis of the 16mer apo-RNA and its Mg2+ RNA complex NMR solution structures revealed that Mg2+-induced structural changes to the GUAA tetraloop act to stabilise the loop via stronger base stacking and intramolecular interactions. Fascinatingly, we discovered that Mg2+ ions provide increased stability required for the formation of a G.A sheared base pair in the GUAA tetraloop. RNA-RNA interactions between the 16mer and 15mer RNAs and their fluorinated analogues were studied by NMR spectroscopy. Small changes to chemical shift and linewidth of proton peaks in the non-fluorinated RNA-RNA complex provided evidence for a weak interaction between the loop of the 16mer RNA and the stem of the 15mer RNA. 19F-NMR experiments revealed additional peaks for the 19F-labelled U179 of the fluorinated 16mer/15mer RNA complex providing further good evidence of RNA-RNA interaction. The NMR structures of the conserved RNA motifs and their interactions have yielded important information in understanding the properties and behaviour of RNA. This will provide the first stepping stone in understanding the IRES mechanism and its use in antiviral therapy and biotechnology.

Subjects/Keywords: 636.089691; FMDV; IRES; GNRA; RNA; NMR; Mg2+; 19F-NMR

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APA (6^th Edition):

Rasul, U. A. (2012). NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/nmr-studies-of-the-structure-kinetics-and-interactions-of-the-conserved-rna-motifs-in-the-fmdv-ires(be21f327-53e1-48aa-bf9c-c4bd2d028417).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554174

Chicago Manual of Style (16^th Edition):

Rasul, Usman Anawar. “NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES.” 2012. Doctoral Dissertation, University of Manchester. Accessed February 25, 2021. https://www.research.manchester.ac.uk/portal/en/theses/nmr-studies-of-the-structure-kinetics-and-interactions-of-the-conserved-rna-motifs-in-the-fmdv-ires(be21f327-53e1-48aa-bf9c-c4bd2d028417).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554174.

MLA Handbook (7^th Edition):

Rasul, Usman Anawar. “NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES.” 2012. Web. 25 Feb 2021.

Vancouver:

Rasul UA. NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Feb 25]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/nmr-studies-of-the-structure-kinetics-and-interactions-of-the-conserved-rna-motifs-in-the-fmdv-ires(be21f327-53e1-48aa-bf9c-c4bd2d028417).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554174.

Council of Science Editors:

Rasul UA. NMR studies of the structure, kinetics and interactions of the conserved RNA motifs in the FMDV IRES. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/nmr-studies-of-the-structure-kinetics-and-interactions-of-the-conserved-rna-motifs-in-the-fmdv-ires(be21f327-53e1-48aa-bf9c-c4bd2d028417).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554174

7. Moutzouri, Pinelopi. New and improved methods for mixture analysis by NMR.

Degree: PhD, 2018, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/new-and-improved-methods-for-mixture-analysis-by-nmr(d6bad99a-36dd-440b-a7b1-f8243a8ab4a3).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756898

► A unique characteristic of NMR is that, unlike other spectroscopic techniques, it separates the excitation of signals from their detection. By manipulating the type of… (more)

Subjects/Keywords: 540; DOSY; Pure shift NMR; 19F NMR; NMR; mixture analysis; 13C satellites

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moutzouri, P. (2018). New and improved methods for mixture analysis by NMR. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/new-and-improved-methods-for-mixture-analysis-by-nmr(d6bad99a-36dd-440b-a7b1-f8243a8ab4a3).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756898

Chicago Manual of Style (16^th Edition):

Moutzouri, Pinelopi. “New and improved methods for mixture analysis by NMR.” 2018. Doctoral Dissertation, University of Manchester. Accessed February 25, 2021. https://www.research.manchester.ac.uk/portal/en/theses/new-and-improved-methods-for-mixture-analysis-by-nmr(d6bad99a-36dd-440b-a7b1-f8243a8ab4a3).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756898.

MLA Handbook (7^th Edition):

Moutzouri, Pinelopi. “New and improved methods for mixture analysis by NMR.” 2018. Web. 25 Feb 2021.

Vancouver:

Moutzouri P. New and improved methods for mixture analysis by NMR. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Feb 25]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/new-and-improved-methods-for-mixture-analysis-by-nmr(d6bad99a-36dd-440b-a7b1-f8243a8ab4a3).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756898.

Council of Science Editors:

Moutzouri P. New and improved methods for mixture analysis by NMR. [Doctoral Dissertation]. University of Manchester; 2018. Available from: https://www.research.manchester.ac.uk/portal/en/theses/new-and-improved-methods-for-mixture-analysis-by-nmr(d6bad99a-36dd-440b-a7b1-f8243a8ab4a3).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.756898

8. 脇田, 和明. マルチモードイメージングを目指した新規核酸イメージングプローブの開発.

Degree: Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学

URL: http://hdl.handle.net/10119/11948

Supervisor:藤本健造教授

マテリアルサイエンス研究科

修士

Subjects/Keywords: 核酸; 19F-NMR; マルチモードイメージング

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APA (6^th Edition):

脇田, �. (n.d.). マルチモードイメージングを目指した新規核酸イメージングプローブの開発. (Thesis). Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10119/11948

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

脇田, 和明. “マルチモードイメージングを目指した新規核酸イメージングプローブの開発.” Thesis, Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学. Accessed February 25, 2021. http://hdl.handle.net/10119/11948.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

脇田, 和明. “マルチモードイメージングを目指した新規核酸イメージングプローブの開発.” Web. 25 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

脇田 �. マルチモードイメージングを目指した新規核酸イメージングプローブの開発. [Internet] [Thesis]. Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学; [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10119/11948.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

脇田 �. マルチモードイメージングを目指した新規核酸イメージングプローブの開発. [Thesis]. Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学; Available from: http://hdl.handle.net/10119/11948

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Waterloo

9. Kralt, Braden. Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR.

Degree: 2020, University of Waterloo

URL: http://hdl.handle.net/10012/15577

► Daptomycin is a calcium-dependent cyclic lipodepsipeptide that is used clinically in the treatment of infections caused by pathogenic Gram-positive organisms, such as methicillin-resistant Staphylococcus aureus.… (more)

▼ Daptomycin is a calcium-dependent cyclic lipodepsipeptide that is used clinically in the treatment of infections caused by pathogenic Gram-positive organisms, such as methicillin-resistant Staphylococcus aureus. Another calcium-dependent cyclic lipodepsipeptide antibiotic, A54145D, also has biological activity against Gram-positive pathogenic organisms, but is not used clinically because it is approximately 4-fold less active than daptomycin. Unlike daptomycin, however, A54145D is not inhibited by lung surfactant in vitro, which makes A54145D a suitable lead compound for the development of other antibiotics that may find use in medical practice as an alternative treatment for community-acquired pneumonia caused by Streptococcus pneumoniae. While the total synthesis of daptomycin has been reported, thus allowing for an efficient method for the generation of analogs of daptomycin, no similar synthesis for A54145D was reported at the start of these studies. To facilitate the development of future antibiotics, a total synthesis of A54145D was developed employing Fmoc-based solid-phase-peptide synthesis. This synthesis enabled us to confirm that the 3-hydroxyasparagine residue has the (2S,3S)-configuration (threo), and the 3-methoxyaspartate residue has the (2S,3R)-configuration (erythro) instead of the (2S,3S)-configuration (threo). Additional analogs of A54145D and A54145A¬1 were synthesized to study the structure-activity relationships of these antibiotics, and it was determined that the threonine residue is not amenable for substitution, in that replacement of threonine caused a dramatic loss in biological activity. Furthermore, it was confirmed that the replacement of the uncommon amino acid 3-methoxyaspartate with aspartate, and 3-hydroxyasparagine with asparagine resulted in a 16-fold reduction of biological activity. To further elucidate the mechanism of action of cyclic lipodepsipeptide antibiotics, which is a matter of some controversy in the scientific literature, ten fluorinated analogs of daptomycin were constructed by semi-synthesis or total synthesis to study their interaction with model membranes using 19F-NMR. These analogs exhibited activity against Bacillus subtilis equal to or approaching that of daptomycin. 19F-NMR studies with a peptide that contained a trifluoromethyl moiety at the end of the lipid tail indicate that at concentrations of daptomycin and calcium that are representative of in vivo conditions, daptomycin does not aggregate in solution. Preliminary 19F-NMR studies with a daptomycin analog containing the CF3 group appended to the ornithine residue at position 6 in the presence of model membranes and varying amounts of calcium suggest that the ornithine residue of daptomycin interacts with biological membranes before the lipid tail does.

Subjects/Keywords: daptomycin; A54145; total synthesis; 19F-NMR; cyclic lipodepsipeptides; antibiotics

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APA (6^th Edition):

Kralt, B. (2020). Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/15577

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kralt, Braden. “Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR.” 2020. Thesis, University of Waterloo. Accessed February 25, 2021. http://hdl.handle.net/10012/15577.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kralt, Braden. “Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR.” 2020. Web. 25 Feb 2021.

Vancouver:

Kralt B. Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR. [Internet] [Thesis]. University of Waterloo; 2020. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10012/15577.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kralt B. Lipodepsipeptide Antibiotics: Total Synthesis and Mechanism of Action Studies Using 19F-NMR. [Thesis]. University of Waterloo; 2020. Available from: http://hdl.handle.net/10012/15577

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

KTH

10. Lehnström, Angelica. Using ¹⁹F-NMR and ¹H-NMR for Analysis of Glucocorticosteroids in Creams and Ointments : -Method Development for Screening, Quantification and Discrimination.

Degree: Chemical Science and Engineering (CHE), 2011, KTH

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-40843

► Topical treatment containing undeclared corticosteroids and illegal topical treatment with corticosteroid content have been seen on the Swedish market. In creams and ointments corticosteroids… (more)

Subjects/Keywords: NMR; 19F; 1H; nuclear magnetic resonance; glucocorticosteroid; corticosteroid

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APA (6^th Edition):

Lehnström, A. (2011). Using ¹⁹F-NMR and ¹H-NMR for Analysis of Glucocorticosteroids in Creams and Ointments : -Method Development for Screening, Quantification and Discrimination. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-40843

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lehnström, Angelica. “Using ¹⁹F-NMR and ¹H-NMR for Analysis of Glucocorticosteroids in Creams and Ointments : -Method Development for Screening, Quantification and Discrimination.” 2011. Thesis, KTH. Accessed February 25, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-40843.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lehnström, Angelica. “Using ¹⁹F-NMR and ¹H-NMR for Analysis of Glucocorticosteroids in Creams and Ointments : -Method Development for Screening, Quantification and Discrimination.” 2011. Web. 25 Feb 2021.

Vancouver:

Lehnström A. Using ¹⁹F-NMR and ¹H-NMR for Analysis of Glucocorticosteroids in Creams and Ointments : -Method Development for Screening, Quantification and Discrimination. [Internet] [Thesis]. KTH; 2011. [cited 2021 Feb 25]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-40843.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lehnström A. Using ¹⁹F-NMR and ¹H-NMR for Analysis of Glucocorticosteroids in Creams and Ointments : -Method Development for Screening, Quantification and Discrimination. [Thesis]. KTH; 2011. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-40843

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brock University

11. Solodinin, Andrei. Synthesis of fluorinated nucleosides for probing DNA conformations via 19F NMR spectroscopy .

Degree: Department of Chemistry, Brock University

URL: http://hdl.handle.net/10464/14475

► Work described in this thesis explored the synthesis of 5-fluoro-2’-deoxycytidine and 8-fluoro-2’-deoxyguanosine, and subsequent incorporation of these modified nucleosides into d(CG) repeat oligonucleotides through the… (more)

Subjects/Keywords: DNA; nucleoside; 19F NMR

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APA (6^th Edition):

Solodinin, A. (n.d.). Synthesis of fluorinated nucleosides for probing DNA conformations via 19F NMR spectroscopy . (Thesis). Brock University. Retrieved from http://hdl.handle.net/10464/14475

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Solodinin, Andrei. “Synthesis of fluorinated nucleosides for probing DNA conformations via 19F NMR spectroscopy .” Thesis, Brock University. Accessed February 25, 2021. http://hdl.handle.net/10464/14475.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Solodinin, Andrei. “Synthesis of fluorinated nucleosides for probing DNA conformations via 19F NMR spectroscopy .” Web. 25 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Solodinin A. Synthesis of fluorinated nucleosides for probing DNA conformations via 19F NMR spectroscopy . [Internet] [Thesis]. Brock University; [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10464/14475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Solodinin A. Synthesis of fluorinated nucleosides for probing DNA conformations via 19F NMR spectroscopy . [Thesis]. Brock University; Available from: http://hdl.handle.net/10464/14475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Virginia Tech

12. Hawrelak, Eric James. Probing Organometallic Reactions With 19F NMR.

Degree: PhD, Chemistry, 2002, Virginia Tech

URL: http://hdl.handle.net/10919/29870

► This dissertation explores fundamental aspects of the reaction of group 4 metallocenes with methylaluminoxane (MAO) that lead to active Ziegler-Natta olefin polymerization catalysts. A novel… (more)

▼ This dissertation explores fundamental aspects of the reaction of group 4 metallocenes with methylaluminoxane (MAO) that lead to active Ziegler-Natta olefin polymerization catalysts. A novel experimental approach is described, in which a unique spectroscopic probe (a fluorinated substituent) is attached to the metallocene ancillary ligands and the metallocene/MAO mixtures are analyzed using 19F NMR spectroscopy. Group 4 metallocene dimethides bearing pentafluorophenyl (C6F5) substituents were synthesized and treated with MAO in benzene-d6. 19F NMR spectroscopic analysis demonstrated reversible methide transfer to form "cation-like" methylmetallocenium methylaluminates. A series of quantitative titration studies showed that fewer than 10% of the aluminum centers in MAO actually participate in the methide transfer process. A systematic study of metallocene substituent effects suggested that MAO contains active centers of extremely high but varying Lewis acidity. Activation of group 4 metallocene dichlorides using MAO was also analyzed using 19F NMR. Initial Cl/CH3 exchange was followed by Cl transfer to aluminum, whereas "normal" subsequent transfer of CH3 from Al to the methylmetallocenium cation was apparently inhibited by the abstracted chloride. Additional studies showed that the 19F NMR probe is sensitive to the interactions of Zr-Cl bonds with simple alkylaluminum species such as Me3Al, Me2AlCl, MeAlCl2, and Et3Al. However, the method was arguably less useful than 1H NMR spectroscopy in following the metathesis of Zr-Cl and Al-R (R = Me, Et) bonds. New methods of preparing methylhalometallocenes were investigated. The reactions of eleven metallocene dimethyls with triphenylmethyl chloride were highly selective (> 95%) with the five most electron-deficient metallocenes studied. Two other examples showed good selectivity on an NMR scale but could not be isolated from the 1,1,1-triphenylethane byproduct. Reactions of dimethylmetallocenes with benzyl bromide were also selective for formation of the corresponding methylbromo-metallocenes, however the reactions were too slow to be of practical value. The observation of long initation periods and the analysis of organic byproduct distributions suggested that these halogenation reactions may proceed by a radical chain mechanism rather than simple sigma bond metathesis. To demonstrate "proof of concept" in the use of 19F NMR to analyze the reactions of paramagnetic metallocenes, the coordination of CO and CN- to C6F5-substituted chromocenes were analyzed. Whereas CO coordinates readily to chromocene, cyanide coordinates effectively to 1,1'-bis(pentafluorophenyl)chromocene. This observation is interpreted in terms of the electron-withdrawing effect of the C6F5 substituent, which should strengthen bonding to sigma-donor ligands (CN-) and weaken bonding to pi-acceptors (CO). Advisors/Committee Members: Deck, Paul A. (committeechair), Gandour, Richard D. (committee member), Tanko, James M. (committee member), Yee, Gordon T. (committee member), Hanson, Brian E. (committee member).

Subjects/Keywords: aluminoxane; metallocene; pentafluorophenyl; 19F NMR

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APA (6^th Edition):

Hawrelak, E. J. (2002). Probing Organometallic Reactions With 19F NMR. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/29870

Chicago Manual of Style (16^th Edition):

Hawrelak, Eric James. “Probing Organometallic Reactions With 19F NMR.” 2002. Doctoral Dissertation, Virginia Tech. Accessed February 25, 2021. http://hdl.handle.net/10919/29870.

MLA Handbook (7^th Edition):

Hawrelak, Eric James. “Probing Organometallic Reactions With 19F NMR.” 2002. Web. 25 Feb 2021.

Vancouver:

Hawrelak EJ. Probing Organometallic Reactions With 19F NMR. [Internet] [Doctoral dissertation]. Virginia Tech; 2002. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10919/29870.

Council of Science Editors:

Hawrelak EJ. Probing Organometallic Reactions With 19F NMR. [Doctoral Dissertation]. Virginia Tech; 2002. Available from: http://hdl.handle.net/10919/29870

13. Magarian, Nicholas J. Mechanistic Studies of Salt Effects on Bimolecular Electron-Transfer Reactions of Pentaamine Ruthenium Pyridyl Complexes Studied by 19F NMR Line-Broadening and T2 Spin-Echo Techniques.

Degree: MSin Chemistry, Chemistry, 2014, University of San Francisco

URL: https://repository.usfca.edu/thes/101

► Kinetic salt effects on the bimolecular ET self-exchange reaction between pentaamineruthenium(II)(3-trifluoromethylpyridine)²⁺, (NH₃)₅Ru^IItfmp²⁺, and pentaamineruthenium(III)(3-trifluoromethylpyridine)³⁺, (NH₃)₅Ru^IIItfmp³⁺, have been measured using both ¹⁹F NMR line-broadening and… (more)

Subjects/Keywords: NMR; T2; 19F NMR; Electron Transfer; Activation parameters; physical inorganic chemistry; Inorganic Chemistry; Physical Chemistry

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APA (6^th Edition):

Magarian, N. J. (2014). Mechanistic Studies of Salt Effects on Bimolecular Electron-Transfer Reactions of Pentaamine Ruthenium Pyridyl Complexes Studied by 19F NMR Line-Broadening and T2 Spin-Echo Techniques. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/thes/101

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Magarian, Nicholas J. “Mechanistic Studies of Salt Effects on Bimolecular Electron-Transfer Reactions of Pentaamine Ruthenium Pyridyl Complexes Studied by 19F NMR Line-Broadening and T2 Spin-Echo Techniques.” 2014. Thesis, University of San Francisco. Accessed February 25, 2021. https://repository.usfca.edu/thes/101.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Magarian, Nicholas J. “Mechanistic Studies of Salt Effects on Bimolecular Electron-Transfer Reactions of Pentaamine Ruthenium Pyridyl Complexes Studied by 19F NMR Line-Broadening and T2 Spin-Echo Techniques.” 2014. Web. 25 Feb 2021.

Vancouver:

Magarian NJ. Mechanistic Studies of Salt Effects on Bimolecular Electron-Transfer Reactions of Pentaamine Ruthenium Pyridyl Complexes Studied by 19F NMR Line-Broadening and T2 Spin-Echo Techniques. [Internet] [Thesis]. University of San Francisco; 2014. [cited 2021 Feb 25]. Available from: https://repository.usfca.edu/thes/101.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Magarian NJ. Mechanistic Studies of Salt Effects on Bimolecular Electron-Transfer Reactions of Pentaamine Ruthenium Pyridyl Complexes Studied by 19F NMR Line-Broadening and T2 Spin-Echo Techniques. [Thesis]. University of San Francisco; 2014. Available from: https://repository.usfca.edu/thes/101

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Bordeaux I

14. Pepin, Cinta. Nanofluorures pour la réduction des déchets dans le cycle du combustible nucléaire : Nanofluorides for the decrease of impurities in the nuclear fuel cycle.

Degree: Docteur es, Physico-Chimie de la Matière Condensée, 2013, Université de Bordeaux I

URL: http://www.theses.fr/2013BOR14881

►

Ce travail porte sur la synthèse et la caractérisation de fluorures divisés obtenus par voiesolvothermale assistée par chauffage micro-ondes pour la réduction des impuretés dans… (more)

Subjects/Keywords: Synthèse micro-ondes; Fluoration F2; RMN 19F; ATG; Microwave synthesis; Fluorination F2; 19F NMR; TGA; 546.731

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APA (6^th Edition):

Pepin, C. (2013). Nanofluorures pour la réduction des déchets dans le cycle du combustible nucléaire : Nanofluorides for the decrease of impurities in the nuclear fuel cycle. (Doctoral Dissertation). Université de Bordeaux I. Retrieved from http://www.theses.fr/2013BOR14881

Chicago Manual of Style (16^th Edition):

Pepin, Cinta. “Nanofluorures pour la réduction des déchets dans le cycle du combustible nucléaire : Nanofluorides for the decrease of impurities in the nuclear fuel cycle.” 2013. Doctoral Dissertation, Université de Bordeaux I. Accessed February 25, 2021. http://www.theses.fr/2013BOR14881.

MLA Handbook (7^th Edition):

Pepin, Cinta. “Nanofluorures pour la réduction des déchets dans le cycle du combustible nucléaire : Nanofluorides for the decrease of impurities in the nuclear fuel cycle.” 2013. Web. 25 Feb 2021.

Vancouver:

Pepin C. Nanofluorures pour la réduction des déchets dans le cycle du combustible nucléaire : Nanofluorides for the decrease of impurities in the nuclear fuel cycle. [Internet] [Doctoral dissertation]. Université de Bordeaux I; 2013. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2013BOR14881.

Council of Science Editors:

Pepin C. Nanofluorures pour la réduction des déchets dans le cycle du combustible nucléaire : Nanofluorides for the decrease of impurities in the nuclear fuel cycle. [Doctoral Dissertation]. Université de Bordeaux I; 2013. Available from: http://www.theses.fr/2013BOR14881

Université Paris-Sud – Paris XI

15. Decamps, Sophie. Synthèse d'inhibiteurs fluorés de carbapénémases : combattre la résistance aux antibiotiques des bactéries à Gram négatif : Synthesis of fluorinated inhibitors of carbapenemases : Fighting antibiotic-resistant Gram-negative bacteria.

Degree: Docteur es, Chimie, 2015, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2015PA114807

►

Le phénomène de résistance des bactéries à Gram négatif aux antibiotiques est aujourd’hui un problème sanitaire mondial majeur. La production de β-lactamases, et plus particulièrement… (more)

▼

Le phénomène de résistance des bactéries à Gram négatif aux antibiotiques est aujourd’hui un problème sanitaire mondial majeur. La production de β-lactamases, et plus particulièrement de carbapénémases, enzymes capables d’hydrolyser la plupart des agents antibactériens de la classe des β-lactames, est le mécanisme de résistance le plus répandu. Dans ce mémoire, nous décrivons la conception et la synthèse de nouveaux inhibiteurs fluorés de carbapénémases. Notre objectif a été la synthèse de monobactames trifluorométhylés en position C4.Nous avons développé une nouvelle voie de synthèse diastéréosélective par expansion de cycle d’aziridines pour l’accès à des 3-bromo-4-CF3-azétidin-2-ones. Ces composés ont été fonctionnalisés par substitution nucléophile, réactions radicalaires et organométalliques en position C3. Dans une seconde partie, des essais de cyclisation de β-hydroxyaminoesters et acides ainsi que de β-hydroxy-hydroxamates ont été entrepris. Pour obtenir ces intermédiaires β-hydroxyaminoesters et acides, nous avons étudié la réactivité des hydroxylamines sur des accepteurs de Michael trifluorométhylés.Enfin, l’évaluation biologique des composés a été réalisée par des tests enzymatiques en suivi par spectroscopie UV. L’évaluation par RMN 19F a également été entreprise, et a permis le développement d’outil de diagnostique et de screening, toujours en cours d’optimisation.

Multidrug resistant gram-negative pathogens are emerging worldwide. β-lactamases production, especially carbapenemases, enzymes with broad hydrolytic capabilities towards β-lactams, is a global spread mechanism of resistance among gram-negative bacteria. We report here the design and the synthesis of new fluorinated inhibitors of carbapenemases. Our aim was to synthesize trifluoromethylated monobactams in C4 position. We have developed a new diastereoselective pathway by ring expansion of aziridines to access to 3-bromo-4-CF3-azetidin-2-ones. These compounds have been successfully functionalized in C3 position via nucleophilic substitution, radical and organometallic reactions.In a second part, cyclisation attempts of β-hydroxyaminoesters and acids, as well as β-hydroxy-hydroxamates have been conducted. A study of Michael addition of hydroxylamines on trifluoromethylated Michael acceptors have been achieved in order to obtain the β-hydroxyaminoesters and acids derivatives.Finally, biological evaluations of synthesized compounds have been realized through enzymatic tests. 19F NMR evaluation have been accomplished and led to development of diagnostic and screening tools, and it is still in under optimisation.

Advisors/Committee Members: Ongeri, Sandrine (thesis director), Crousse, Benoit (thesis director).

Subjects/Keywords: Antibiotiques; Β-lactamases; Monobactames trifluorométhylés; Hydroxylamines; RMN 19F; Antibiotics; Β-lactamases; Trifluoromethylated monobactames; Hydroxylamines; 19F NMR

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APA (6^th Edition):

Decamps, S. (2015). Synthèse d'inhibiteurs fluorés de carbapénémases : combattre la résistance aux antibiotiques des bactéries à Gram négatif : Synthesis of fluorinated inhibitors of carbapenemases : Fighting antibiotic-resistant Gram-negative bacteria. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2015PA114807

Chicago Manual of Style (16^th Edition):

Decamps, Sophie. “Synthèse d'inhibiteurs fluorés de carbapénémases : combattre la résistance aux antibiotiques des bactéries à Gram négatif : Synthesis of fluorinated inhibitors of carbapenemases : Fighting antibiotic-resistant Gram-negative bacteria.” 2015. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed February 25, 2021. http://www.theses.fr/2015PA114807.

MLA Handbook (7^th Edition):

Decamps, Sophie. “Synthèse d'inhibiteurs fluorés de carbapénémases : combattre la résistance aux antibiotiques des bactéries à Gram négatif : Synthesis of fluorinated inhibitors of carbapenemases : Fighting antibiotic-resistant Gram-negative bacteria.” 2015. Web. 25 Feb 2021.

Vancouver:

Decamps S. Synthèse d'inhibiteurs fluorés de carbapénémases : combattre la résistance aux antibiotiques des bactéries à Gram négatif : Synthesis of fluorinated inhibitors of carbapenemases : Fighting antibiotic-resistant Gram-negative bacteria. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2015. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2015PA114807.

Council of Science Editors:

Decamps S. Synthèse d'inhibiteurs fluorés de carbapénémases : combattre la résistance aux antibiotiques des bactéries à Gram négatif : Synthesis of fluorinated inhibitors of carbapenemases : Fighting antibiotic-resistant Gram-negative bacteria. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2015. Available from: http://www.theses.fr/2015PA114807

University of Wollongong

16. Chilingaryan, Zorik. DnaG as an antibacterial target.

Degree: PhD, 2015, University of Wollongong

URL: 060112 Structural Biology (incl. Macromolecular Modelling) ; https://ro.uow.edu.au/theses/4487

► The rise of “superbugs” – antibiotic resistant infection-causing bacteria - poses a catastrophic threat to public health, and prompts the investigation of new drug… (more)

Subjects/Keywords: fragment-based screening; surface plasmon resonance; STD-NMR; HSQC-NMR; molecular docking; molecular dynamics; 19F-NMR; autodock vina; DnaG primase; SSB

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APA (6^th Edition):

Chilingaryan, Z. (2015). DnaG as an antibacterial target. (Doctoral Dissertation). University of Wollongong. Retrieved from 060112 Structural Biology (incl. Macromolecular Modelling) ; https://ro.uow.edu.au/theses/4487

Chicago Manual of Style (16^th Edition):

Chilingaryan, Zorik. “DnaG as an antibacterial target.” 2015. Doctoral Dissertation, University of Wollongong. Accessed February 25, 2021. 060112 Structural Biology (incl. Macromolecular Modelling) ; https://ro.uow.edu.au/theses/4487.

MLA Handbook (7^th Edition):

Chilingaryan, Zorik. “DnaG as an antibacterial target.” 2015. Web. 25 Feb 2021.

Vancouver:

Chilingaryan Z. DnaG as an antibacterial target. [Internet] [Doctoral dissertation]. University of Wollongong; 2015. [cited 2021 Feb 25]. Available from: 060112 Structural Biology (incl. Macromolecular Modelling) ; https://ro.uow.edu.au/theses/4487.

Council of Science Editors:

Chilingaryan Z. DnaG as an antibacterial target. [Doctoral Dissertation]. University of Wollongong; 2015. Available from: 060112 Structural Biology (incl. Macromolecular Modelling) ; https://ro.uow.edu.au/theses/4487

NSYSU

17. Shi, Cheng-Yu. Investigation of the mechanism of radical attack in NafionÂ®117membrane with nuclear magnetic resonance relaxation and weighted imaging.

Degree: Master, Chemistry, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0002114-183305

► PEMs degradation can be classified into mechanical, thermal and chemical/electrochemical degradation. The first two are usually responsible for the early stage failure of PEMFCs and… (more)

Subjects/Keywords: Nafion; PEMFCs; MRI-T1 weighted imaging; 19F MAS NMR; Fentonâs reactions; degradation

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APA (6^th Edition):

Shi, C. (2014). Investigation of the mechanism of radical attack in NafionÂ®117membrane with nuclear magnetic resonance relaxation and weighted imaging. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0002114-183305

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shi, Cheng-Yu. “Investigation of the mechanism of radical attack in NafionÂ®117membrane with nuclear magnetic resonance relaxation and weighted imaging.” 2014. Thesis, NSYSU. Accessed February 25, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0002114-183305.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shi, Cheng-Yu. “Investigation of the mechanism of radical attack in NafionÂ®117membrane with nuclear magnetic resonance relaxation and weighted imaging.” 2014. Web. 25 Feb 2021.

Vancouver:

Shi C. Investigation of the mechanism of radical attack in NafionÂ®117membrane with nuclear magnetic resonance relaxation and weighted imaging. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Feb 25]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0002114-183305.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shi C. Investigation of the mechanism of radical attack in NafionÂ®117membrane with nuclear magnetic resonance relaxation and weighted imaging. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0002114-183305

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kentucky

18. Varner, Taylor. FLAVODOXIN, THE HYDROGEN ATOM OF FLAVOPROTEINS: A 19F NMR STUDY OF DYNAMICS AND CONFORMATIONAL CHANGES UTILIZING FLAVODOXIN FROM RHODOPSEUDOMONAS PALUSTRIS.

Degree: 2020, University of Kentucky

URL: https://uknowledge.uky.edu/chemistry_etds/134

► Flavodoxin is a small, highly stable protein that contain a single FMN cofactor used to transfer single electrons at low potentials. The organism Rhodopseudomonas palustris… (more)

Subjects/Keywords: 19F NMR; fluoro tyrosine; Long-chain flavodoxin; Flavoprotein; Analytical Chemistry; Biochemistry; Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Varner, T. (2020). FLAVODOXIN, THE HYDROGEN ATOM OF FLAVOPROTEINS: A 19F NMR STUDY OF DYNAMICS AND CONFORMATIONAL CHANGES UTILIZING FLAVODOXIN FROM RHODOPSEUDOMONAS PALUSTRIS. (Masters Thesis). University of Kentucky. Retrieved from https://uknowledge.uky.edu/chemistry_etds/134

Chicago Manual of Style (16^th Edition):

Varner, Taylor. “FLAVODOXIN, THE HYDROGEN ATOM OF FLAVOPROTEINS: A 19F NMR STUDY OF DYNAMICS AND CONFORMATIONAL CHANGES UTILIZING FLAVODOXIN FROM RHODOPSEUDOMONAS PALUSTRIS.” 2020. Masters Thesis, University of Kentucky. Accessed February 25, 2021. https://uknowledge.uky.edu/chemistry_etds/134.

MLA Handbook (7^th Edition):

Varner, Taylor. “FLAVODOXIN, THE HYDROGEN ATOM OF FLAVOPROTEINS: A 19F NMR STUDY OF DYNAMICS AND CONFORMATIONAL CHANGES UTILIZING FLAVODOXIN FROM RHODOPSEUDOMONAS PALUSTRIS.” 2020. Web. 25 Feb 2021.

Vancouver:

Varner T. FLAVODOXIN, THE HYDROGEN ATOM OF FLAVOPROTEINS: A 19F NMR STUDY OF DYNAMICS AND CONFORMATIONAL CHANGES UTILIZING FLAVODOXIN FROM RHODOPSEUDOMONAS PALUSTRIS. [Internet] [Masters thesis]. University of Kentucky; 2020. [cited 2021 Feb 25]. Available from: https://uknowledge.uky.edu/chemistry_etds/134.

Council of Science Editors:

Varner T. FLAVODOXIN, THE HYDROGEN ATOM OF FLAVOPROTEINS: A 19F NMR STUDY OF DYNAMICS AND CONFORMATIONAL CHANGES UTILIZING FLAVODOXIN FROM RHODOPSEUDOMONAS PALUSTRIS. [Masters Thesis]. University of Kentucky; 2020. Available from: https://uknowledge.uky.edu/chemistry_etds/134

Georgia Tech

19. Gross, Jeffrey David. Non-invasive Monitoring of Oxygen Concentrations and Metabolic Function in Pancreatic Substitutes.

Degree: PhD, Biomedical Engineering, 2007, Georgia Tech

URL: http://hdl.handle.net/1853/14499

► Design and characterization of tissue engineered substitutes rely on robust monitoring techniques that provide information regarding viability and function when exposed to various environmental conditions.… (more)

▼ Design and characterization of tissue engineered substitutes rely on robust monitoring techniques that provide information regarding viability and function when exposed to various environmental conditions. In vitro studies permit the direct monitoring of cellular and construct changes because these substitutes remain accessible. However, upon in vivo implantation, changes in cell viability and function are often detected using indirect or invasive methods that make assessing temporal changes challenging. . Thus, the development of non-invasive monitoring modalities may facilitate improved tissue substitute design and, ultimately, clinical outcome. The overall objective of this thesis was to establish a method to monitor and track cells and the cellular environment within a tissue engineered substitute in vitro and in vivo. This was accomplished via 31P NMR spectroscopy and through the incorporation of perfluorocarbon (PFC) emulsions for the monitoring of DO concentration by 19F NMR spectroscopy. The first aim of this thesis was to develop a method that tracked the state of cells and of the cellular environment within alginate constructs during perfusion studies in which the perfusing medium DO concentrations were changed over time or cells were exposed to a cytotoxic antibiotic. Due to challenges in acquiring DO concentration gradient information within beads, a second aim was to develop a mathematical model that would calculate gradients from experimentally acquired volume averaged DO concentrations; thus, significantly enhancing the robustness of tracking the alginate beads. Lastly, since the PFC emulsions used in the study may affect cell viability and function, a third aim was to characterize, experimentally and via modeling, the effect of several PFC emulsion concentrations on the encapsulated and946;TC-tet cells. Advisors/Committee Members: Sambanis, Athanassios (Committee Chair), Chaikof, Elliot (Committee Member), Constantinidis, Ioannis (Committee Member), Edmondson, Dale (Committee Member), Long, Jr., Robert (Committee Member).

Subjects/Keywords: 19F NMR; Perfluorocarbon; Pancreatic substitute; Oxygen

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APA (6^th Edition):

Gross, J. D. (2007). Non-invasive Monitoring of Oxygen Concentrations and Metabolic Function in Pancreatic Substitutes. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/14499

Chicago Manual of Style (16^th Edition):

Gross, Jeffrey David. “Non-invasive Monitoring of Oxygen Concentrations and Metabolic Function in Pancreatic Substitutes.” 2007. Doctoral Dissertation, Georgia Tech. Accessed February 25, 2021. http://hdl.handle.net/1853/14499.

MLA Handbook (7^th Edition):

Gross, Jeffrey David. “Non-invasive Monitoring of Oxygen Concentrations and Metabolic Function in Pancreatic Substitutes.” 2007. Web. 25 Feb 2021.

Vancouver:

Gross JD. Non-invasive Monitoring of Oxygen Concentrations and Metabolic Function in Pancreatic Substitutes. [Internet] [Doctoral dissertation]. Georgia Tech; 2007. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1853/14499.

Council of Science Editors:

Gross JD. Non-invasive Monitoring of Oxygen Concentrations and Metabolic Function in Pancreatic Substitutes. [Doctoral Dissertation]. Georgia Tech; 2007. Available from: http://hdl.handle.net/1853/14499

Penn State University

20. Basehore, Heather Kenney. CHARACTERIZATION OF THE EARLY INTERACTIONS ON THE FOLDING PATHWAY OF THE ILEAL LIPID-BINDING PROTEIN BY 19F-NMR .

Degree: 2008, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/7834

► Determining whether two structurally related proteins fold via similar mechanisms is an important question in structural biology. Intracellular lipid-binding proteins (iLBP’s) are a large family… (more)

▼ Determining whether two structurally related proteins fold via similar mechanisms is an important question in structural biology. Intracellular lipid-binding proteins (iLBP’s) are a large family of proteins that share a common ?-barrel structure in spite of very low sequence similarities. One member of this family, intestinal fatty acid-binding protein (IFABP) has been shown to fold by a mechanism of specific hydrophobic collapse in a core structural region. These kinetic folding intermediates differ from intermediates observed for the structurally related protein, ileal lipid-binding protein (ILBP). There is some evidence that both proteins initiate folding by the same mechanism, but that stable folding intermediates do not accumulate to the same level for both. The proposed folding mechanism of IFABP is supported by equilibrium unfolding studies by 19F-NMR. Residues in contact with each other in the native protein retain elements of structure at denaturant concentrations much higher than the unfolding midpoint concentrations. This is manifested in the 19F-NMR spectra in the form of NMR spectral changes that differ in response to denaturant depending on the residue’s role in the folding pathway. Similar analysis of ILBP demonstrates that some residues in this protein also display non-uniform behavior by 19F-NMR with increasing denaturant, although the residues responsible for this behavior were not identified in the initial analysis. By labeling the protein with 19F one residue at a time, assignment of the peak resonances for each 19F-Phe in ILBP have now been made. The results of these 19F-NMR experiments reveal that some of the interactions that occur early in folding may be conserved, but the specific nature of the initiating reactions differs for these two related proteins. Advisors/Committee Members: Ira Joseph Ropson, Committee Chair/Co-Chair, Dr Michael Pishko, Committee Member, Cara Lynne Schengrund, Committee Member, Michael Verderame, Committee Member.

Subjects/Keywords: b-sheet proteins; 19F-NMR; protein folding

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Basehore, H. K. (2008). CHARACTERIZATION OF THE EARLY INTERACTIONS ON THE FOLDING PATHWAY OF THE ILEAL LIPID-BINDING PROTEIN BY 19F-NMR . (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/7834

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Basehore, Heather Kenney. “CHARACTERIZATION OF THE EARLY INTERACTIONS ON THE FOLDING PATHWAY OF THE ILEAL LIPID-BINDING PROTEIN BY 19F-NMR .” 2008. Thesis, Penn State University. Accessed February 25, 2021. https://submit-etda.libraries.psu.edu/catalog/7834.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Basehore, Heather Kenney. “CHARACTERIZATION OF THE EARLY INTERACTIONS ON THE FOLDING PATHWAY OF THE ILEAL LIPID-BINDING PROTEIN BY 19F-NMR .” 2008. Web. 25 Feb 2021.

Vancouver:

Basehore HK. CHARACTERIZATION OF THE EARLY INTERACTIONS ON THE FOLDING PATHWAY OF THE ILEAL LIPID-BINDING PROTEIN BY 19F-NMR . [Internet] [Thesis]. Penn State University; 2008. [cited 2021 Feb 25]. Available from: https://submit-etda.libraries.psu.edu/catalog/7834.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Basehore HK. CHARACTERIZATION OF THE EARLY INTERACTIONS ON THE FOLDING PATHWAY OF THE ILEAL LIPID-BINDING PROTEIN BY 19F-NMR . [Thesis]. Penn State University; 2008. Available from: https://submit-etda.libraries.psu.edu/catalog/7834

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Thach, William. Protein Folding and Dynamics of Calmodulin via 19F-NMR.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/33562

►

Calmodulin (CaM) is a ubiquitous calcium sensor protein which binds and activates a variety of enzymes involved in cell signaling pathways. In its calcium loaded… (more)

Subjects/Keywords: Protein Folding; Calmodulin; 19F-NMR; CPMG; 0487

…file 1CLL) showing the location 9 of the eight phenylalanine residues B) 19F NMR… …NMR Solvent Isotope 18 Shifts Figure 12 Temperature Dependence of Normalized 19F NMR… …objective of the work presented in this thesis is the application of 19F NMR to the study of… …penetration and hydrophobicity using 19F NMR. Subsequently, the dynamics involved in this process… …protein folding is discussed. (2) 19F NMR & biosynthetic labeling: We begin by…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thach, W. (2012). Protein Folding and Dynamics of Calmodulin via 19F-NMR. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/33562

Chicago Manual of Style (16^th Edition):

Thach, William. “Protein Folding and Dynamics of Calmodulin via 19F-NMR.” 2012. Masters Thesis, University of Toronto. Accessed February 25, 2021. http://hdl.handle.net/1807/33562.

MLA Handbook (7^th Edition):

Thach, William. “Protein Folding and Dynamics of Calmodulin via 19F-NMR.” 2012. Web. 25 Feb 2021.

Vancouver:

Thach W. Protein Folding and Dynamics of Calmodulin via 19F-NMR. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1807/33562.

Council of Science Editors:

Thach W. Protein Folding and Dynamics of Calmodulin via 19F-NMR. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/33562

Freie Universität Berlin

22. Gerling, Ulla I.M. Evaluierung des Einflusses von Fluor auf die Amyloidbildung – eine systematische Studie an einem Coiled coil-basierten Modellpeptid.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-7640

► A common hallmark of many neurodegenerative diseases is the conformational transition of peptides from a native, functional form into insoluble amyloid deposits. Amyloid formation, however,… (more)

▼ A common hallmark of many neurodegenerative diseases is the conformational transition of peptides from a native, functional form into insoluble amyloid deposits. Amyloid formation, however, is not a specific feature of disease- related proteins, but instead appears to be a general property of peptides and proteins. The outstanding mechanical stability and remarkably regular fibrous architecture have made amyloids also attractive materials for bio- or nano- technological applications. In this regard nonnatural building blocks and fluorinated amino acids in particular, have become standard tools for modulating such structures. Due to its unique stereoelectronic properties fluorine can have dramatic effects on structure, function, and stability of peptides and proteins. Previous approaches to assessing the properties of fluorinated amino acids have mainly focused on helical systems. In terms of amyloid forming peptides, fluorine has mainly been used as diagnostic reporter group. As to what extend fluorination influences the process of amyloid formation has not been investigated systematically so far. The present thesis evaluates the impact of fluorine on amyloid formation with the help of a model peptide that was developed in the group of Prof. Dr. Beate Koksch. The model was designed to provide an α-helical starting structure that can fold into β-sheet rich amyloids under controlled conditions. Previous studies revealed solid structural information about the initial coiled coil structure and the final fibril architecture, which serve as a basis for the present investigations. In the course of this work two neighboring valine residues that play a key role in the structural transition were replaced by several fluorinated amino acids that contain different fluorine content in their side chains. These amino acids vary with regard to their intrinsic properties, such as size, hydrophobicity, and secondary structure propensities. By means of this systematic approach the properties of fluorinated amino acids have been investigated for their impact on the amyloid formation process. The resulting peptides, which have been analyzed by a battery of high and low resolution techniques, show unexpected folding behaviors as a consequence of the interplay between stereoelectronic effects that can be directly attributed to the particular incorporated amino acid. By determining the critical size of the nucleus, an intermediate species that serves as template for peptide aggregation, a potential pathway for the structural transition has been suggested. The results of this thesis will contribute to an understanding of amyloid formation and how this process can be modulated by fluorinated amino acids. Advisors/Committee Members: w (gender), Prof. Dr. Beate Koksch (firstReferee), Prof. Dr. Rainer Haag (furtherReferee).

Subjects/Keywords: Amyloid formation; Fluorinated amino acids; Hydrophobicicy; Helix propensity; solid state 19F NMR; 500 Naturwissenschaften und Mathematik::540 Chemie

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gerling, U. I. M. (2014). Evaluierung des Einflusses von Fluor auf die Amyloidbildung – eine systematische Studie an einem Coiled coil-basierten Modellpeptid. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7640

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gerling, Ulla I M. “Evaluierung des Einflusses von Fluor auf die Amyloidbildung – eine systematische Studie an einem Coiled coil-basierten Modellpeptid.” 2014. Thesis, Freie Universität Berlin. Accessed February 25, 2021. http://dx.doi.org/10.17169/refubium-7640.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gerling, Ulla I M. “Evaluierung des Einflusses von Fluor auf die Amyloidbildung – eine systematische Studie an einem Coiled coil-basierten Modellpeptid.” 2014. Web. 25 Feb 2021.

Vancouver:

Gerling UIM. Evaluierung des Einflusses von Fluor auf die Amyloidbildung – eine systematische Studie an einem Coiled coil-basierten Modellpeptid. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Feb 25]. Available from: http://dx.doi.org/10.17169/refubium-7640.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gerling UIM. Evaluierung des Einflusses von Fluor auf die Amyloidbildung – eine systematische Studie an einem Coiled coil-basierten Modellpeptid. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-7640

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Dodin, Mathias. Synthèse de nouveaux solides microporeux à base de silice en présence de structurants organiques originaux : Synthesis of new silica-based microporous solids in the presence of original structure-directing agents.

Degree: Docteur es, Chimie des matériaux, 2010, Mulhouse

URL: http://www.theses.fr/2010MULH5273

►

La synthèse de matériaux zéolithiques est régie par de nombreux paramètres, en particulier la nature de l'hétéroélément associé au silicium et celle de l'agent organique… (more)

▼

La synthèse de matériaux zéolithiques est régie par de nombreux paramètres, en particulier la nature de l'hétéroélément associé au silicium et celle de l'agent organique structurant. Ainsi, l'introduction de germanium dans les milieux réactionnels ainsi que l'utilisation de structurants dérivés d'imidazole, les cations 1-éthyl-3-méthylimidazolium et 1-butyl-3-méthylimidazolium, ont permis la découverte de deux nouveaux solides microporeux nommés respectivement IM-16 et IM-20 et présentant des topologies de charpente inédites (respectivement UOS et UWY). De plus, un troisième germanosilicate poreux nommé IM-17 a été obtenu en présence du cation décaméthonium. Chacun de ces trois matériaux possède un système tridimensionnel de canaux avec des ouvertures de 8 et 10 atomes T (IM-16) ou de 10 et 12 atomes T (IM-17 et IM-20), ainsi que des unités de construction composites d4r au sein de leur charpente. Enfin, une partie importante du travail a été consacrée à l'élaboration de molécules structurantes originales (dérivés du décahydro-dicyclopenta[b,d]pyrrole) puis de leur emploi en synthèse hydrothermale. Ces essais ont permis d'obtenir divers matériaux déjà connus, parmi lesquels les zéolithes IM-12 (UTL), ITQ-7 (ISV), ITQ-17 (BEC) et ITQ-21.

The synthesis of zeolitic materials is ruled by numerous parameters, particularly the nature of the heteroelement associated with silicon and of the organic structure-directing agent (SDA). The introduction of germanium into the synthesis gels and the use of imidazole-derived SDAs, the cations 1-ethyl-3-methylimidazolium and 1-butyl-3-methylimidazolium, allowed us to discover two new microporous solids named IM-16 and IM-20 and exhibiting novel framework structures (respectively UOS and UWY). Furthermore, a third porous germanosilicate named IM-17 was obtained in the presence of the decamethonium cation. Each of these materials possesses a three-dimensional channel system with 8- and 10-ring pores (IM-16) or 10- and 12-ring pores (IM-17 and IM-20), as well as double-4-ring (d4r) composite building units in their framework. Finally, an important part of this work was dedicated to the elaboration of original SDAs (decahydro-dicyclopenta[b,d]pyrrole derivatives) and their use in hydrothermal synthesis. This led to the synthesis of several known zeolites such as IM-12 (UTL), ITQ-7 (ISV), ITQ-17 (BEC) and ITQ-21.

Advisors/Committee Members: Paillaud, Jean-Louis (thesis director).

Subjects/Keywords: Zéolithe; Germanosilicate; Synthèse hydrothermale; Détermination structurale sur poudre; Méthode Rietveld; Unité d4r; Imidazolium; 19F, 29Si MAS NMR; Zeolite; Germanosilicate; Hydrothermal synthesis; Structure determination from powder; Rietveld method; D4r unit; Imidazolium; 19F, 29Si MAS NMR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dodin, M. (2010). Synthèse de nouveaux solides microporeux à base de silice en présence de structurants organiques originaux : Synthesis of new silica-based microporous solids in the presence of original structure-directing agents. (Doctoral Dissertation). Mulhouse. Retrieved from http://www.theses.fr/2010MULH5273

Chicago Manual of Style (16^th Edition):

Dodin, Mathias. “Synthèse de nouveaux solides microporeux à base de silice en présence de structurants organiques originaux : Synthesis of new silica-based microporous solids in the presence of original structure-directing agents.” 2010. Doctoral Dissertation, Mulhouse. Accessed February 25, 2021. http://www.theses.fr/2010MULH5273.

MLA Handbook (7^th Edition):

Dodin, Mathias. “Synthèse de nouveaux solides microporeux à base de silice en présence de structurants organiques originaux : Synthesis of new silica-based microporous solids in the presence of original structure-directing agents.” 2010. Web. 25 Feb 2021.

Vancouver:

Dodin M. Synthèse de nouveaux solides microporeux à base de silice en présence de structurants organiques originaux : Synthesis of new silica-based microporous solids in the presence of original structure-directing agents. [Internet] [Doctoral dissertation]. Mulhouse; 2010. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2010MULH5273.

Council of Science Editors:

Dodin M. Synthèse de nouveaux solides microporeux à base de silice en présence de structurants organiques originaux : Synthesis of new silica-based microporous solids in the presence of original structure-directing agents. [Doctoral Dissertation]. Mulhouse; 2010. Available from: http://www.theses.fr/2010MULH5273

24. Felouat, Abdellah. Synthèse et études photophysiques de matériaux PI-conjugés - Complexes de difluorure de Bore des ligands Beta-dicétone à conjugaison PI-étendue : Synthesis and Photophysical studies of π-conjugated materials-Boron difluoride complexes of β-diketonates ligands with extended π-conjugation.

Degree: Docteur es, Chimie Organique, 2014, Aix Marseille Université

URL: http://www.theses.fr/2014AIXM4036

►

Une nouvelle famille de complexes de difluorure de bore photosensibles est développée. Elle est basée sur des structures moléculaires contenant une unité β-dicétone à conjugaison… (more)

▼

Une nouvelle famille de complexes de difluorure de bore photosensibles est développée. Elle est basée sur des structures moléculaires contenant une unité β-dicétone à conjugaison électronique π.La grande variété de groupements aromatiques et la nature donneur ou accepteur d'électrons des différents substituants permet l'élaboration de systèmes électroniques donneur-accepteur-donneur d'électrons (D1-A-D1) et donneur-accepteur (D2-A).L'absorption électronique de cette famille de molécule se situe dans la partie visible du spectre électromagnétique et une partie du spectre ultraviolet, et est caractérisée par une bande d'absorption π-π* intense avec des coefficients d'absorption molaire supérieurs à 50 000 M-1cm-1.L'émission de fluorescence couvre une plage spectrale qui va du visible au proche infrarouge avec des rendements quantiques de fluorescence en solution relativement élevés pouvant atteindre 62 %.En fin, cette famille de molécule est photochimiquement stable et est, contrairement à d'autres familles de complexes de difluorure de bore, chimiquement très stable en solution.Mots-clés : Difluorure de bore, β-dicétone, matériaux π-conjugués, luminescence, fluorescence stationnaire et résolue dans le temps (TRES), synthèse organique, RMN-19F dynamique, complexes & colorants fluorescents, curcumine & curcuminoide, complexe BF2, photophysique.

A new photosensitive family of boron difluoride complex is developed. It is based on π-conjugated molecular structures containing β-diketonates unit.The wide variety of aromatic groups and the nature of donor or electron acceptor of the different substituents allow the development of electron donor-acceptor-donor (DAD) and donor-acceptor (DA) electronic systems.The electronic absorption of this family of molecules is in the visible part of the electromagnetic spectrum and a portion of the ultraviolet spectrum, and is characterized by an intense π-π* absorption band with molar absorption coefficient greater than 50 000 M-1.cm-1.The fluorescence emission covers a spectral range going from visible to near infrared, with relatively high fluorescence quantum yields of up to 62 % in solution.This new material family is photochemically stable and, unlike some other families of boron difluoride complexes, chemically very stable in solution.

Advisors/Committee Members: Fagès, Frédéric (thesis director).

Subjects/Keywords: Difluorure de bore; Β-Dicétone; Matériaux π-Conjugués; Luminescence; Fluorescence stationnaire et résolue dans le temps (TRES); Synthèse organique; RMN-19F dynamique; Complexes & colorants fluorescents; Curcumine & curcuminoide; Complexe BF; Boron difluoride; Β-Diketone; Π-Conjugated materials; Stationary & time-Resolved fluorescence (TRES); Photophysics; Organic synthesis; Luminescence; Fluorescent complexes & dyes; Dynamic 19F-NMR (19F-DNMR); Curcumin & curcuminoid; BF2 compl; 540

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Felouat, A. (2014). Synthèse et études photophysiques de matériaux PI-conjugés - Complexes de difluorure de Bore des ligands Beta-dicétone à conjugaison PI-étendue : Synthesis and Photophysical studies of π-conjugated materials-Boron difluoride complexes of β-diketonates ligands with extended π-conjugation. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2014AIXM4036

Chicago Manual of Style (16^th Edition):

Felouat, Abdellah. “Synthèse et études photophysiques de matériaux PI-conjugés - Complexes de difluorure de Bore des ligands Beta-dicétone à conjugaison PI-étendue : Synthesis and Photophysical studies of π-conjugated materials-Boron difluoride complexes of β-diketonates ligands with extended π-conjugation.” 2014. Doctoral Dissertation, Aix Marseille Université. Accessed February 25, 2021. http://www.theses.fr/2014AIXM4036.

MLA Handbook (7^th Edition):

Felouat, Abdellah. “Synthèse et études photophysiques de matériaux PI-conjugés - Complexes de difluorure de Bore des ligands Beta-dicétone à conjugaison PI-étendue : Synthesis and Photophysical studies of π-conjugated materials-Boron difluoride complexes of β-diketonates ligands with extended π-conjugation.” 2014. Web. 25 Feb 2021.

Vancouver:

Felouat A. Synthèse et études photophysiques de matériaux PI-conjugés - Complexes de difluorure de Bore des ligands Beta-dicétone à conjugaison PI-étendue : Synthesis and Photophysical studies of π-conjugated materials-Boron difluoride complexes of β-diketonates ligands with extended π-conjugation. [Internet] [Doctoral dissertation]. Aix Marseille Université 2014. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2014AIXM4036.

Council of Science Editors:

Felouat A. Synthèse et études photophysiques de matériaux PI-conjugés - Complexes de difluorure de Bore des ligands Beta-dicétone à conjugaison PI-étendue : Synthesis and Photophysical studies of π-conjugated materials-Boron difluoride complexes of β-diketonates ligands with extended π-conjugation. [Doctoral Dissertation]. Aix Marseille Université 2014. Available from: http://www.theses.fr/2014AIXM4036

Université de Grenoble

25. El Kaddouri, Assma. Mise en évidcence de la dégradation du liant ionomère dans les électrodes de pile à combustible : Evidence for degradation of ionomer binder in electrodes of fuel cell.

Degree: Docteur es, Matériaux, mécanique, génie civil, électrochimie, 2014, Université de Grenoble

URL: http://www.theses.fr/2014GRENI014

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Ce travail de thèse a pour but de suivre le comportement du liant ionomère après vieillissement en condition réelle d'utilisation de la pile. Dans un… (more)

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Ce travail de thèse a pour but de suivre le comportement du liant ionomère après vieillissement en condition réelle d'utilisation de la pile. Dans un premier temps, diverses techniques de caractérisation en phase solide ont été utilisées afin d'étudier le ionomère présent dans les électrodes. La majeure partie de ces techniques se sont avérées insatisfaisantes pour le suivi du vieillissement du ionomère. Seule l'analyse par diffraction rayon X (DRX) a mis en avant un changement d'organisation structurale du ionomère dans les électrodes. Par la suite, nous avons choisi de caractériser le ionomère en solution après extraction par l'eau. Préalablement, un protocole de quantification en 2 à 3 étapes, dans lequel intervient une quantification via le rapport signal-sur-bruit (S/N), a été mis en place afin de quantifier le Nafion® et autres petites molécules fluorés. L'extraction Soxhlet a ensuite été réalisée sur les électrodes permettant de révéler la présence d'un produit de dégradation hydrosoluble après fonctionnement en pile, à la fois en cathode et en anode. Enfin, la macération des électrodes dans le diméthylacétamide (DMAc) a permis d'extraire le polymère Nafion® ainsi que deux acides : l'acide trifluoroacétique (TFA) et l'acide triflique (TFI). En conclusion, la corrélation de l'ensemble des observations nous a permis de proposer un mécanisme de dégradation du liant ionomère présent dans les électrodes.

The purpose of this study was to follow the behavior of ionomer binder after fuel cell operation. First, a series of techniques were used to investigate to characterize ionomer in electrode at solid state. Most of them were inefficient to study ionomer degradation. Only X-Ray Diffraction (XRD) pointed out a structural change of the binder in electrodes. Second, it has been decided to characterize ionomer in liquid state after water extraction. But first of all, a quantitative 19F NMR protocol composed of two to three steps, with a first step using a quantification through signal-to-noise ratio (S/N), was establish in order to quantify Nafion® and degradation products. Soxhlet extraction performed on electrodes allowed to detect a degradation product water-soluble. Finally, extraction with organic solvent (Dimethylacetamide) allowed to extract Nafion® and two acid: trifluoroacetic acid (TFA) and triflic acid (TFI) from electrodes. In conclusion, correlation between observation and literature allowed us to propose a degradation mechanism of ionomer in electrodes.

Advisors/Committee Members: Bas, Corine (thesis director), Flandin, Lionel (thesis director).

Subjects/Keywords: PEMFC; Électrode; Ionomère; PFSA; Nafion®; Dégradation; Liant; RMN 19F; Acide trifluoroacétique; Acide triflique; Extraction Soxhlet; Rapport signal-sur-bruit; PEMFC; Electrode; Ionomer; PFSA; Nafion®; Degradation; Binder; 19F NMR; Trifluoroacetic acid; Triflic acid; Soxhlet extraction; Signal-to-noise ratio; 620

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

El Kaddouri, A. (2014). Mise en évidcence de la dégradation du liant ionomère dans les électrodes de pile à combustible : Evidence for degradation of ionomer binder in electrodes of fuel cell. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2014GRENI014

Chicago Manual of Style (16^th Edition):

El Kaddouri, Assma. “Mise en évidcence de la dégradation du liant ionomère dans les électrodes de pile à combustible : Evidence for degradation of ionomer binder in electrodes of fuel cell.” 2014. Doctoral Dissertation, Université de Grenoble. Accessed February 25, 2021. http://www.theses.fr/2014GRENI014.

MLA Handbook (7^th Edition):

El Kaddouri, Assma. “Mise en évidcence de la dégradation du liant ionomère dans les électrodes de pile à combustible : Evidence for degradation of ionomer binder in electrodes of fuel cell.” 2014. Web. 25 Feb 2021.

Vancouver:

El Kaddouri A. Mise en évidcence de la dégradation du liant ionomère dans les électrodes de pile à combustible : Evidence for degradation of ionomer binder in electrodes of fuel cell. [Internet] [Doctoral dissertation]. Université de Grenoble; 2014. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2014GRENI014.

Council of Science Editors:

El Kaddouri A. Mise en évidcence de la dégradation du liant ionomère dans les électrodes de pile à combustible : Evidence for degradation of ionomer binder in electrodes of fuel cell. [Doctoral Dissertation]. Université de Grenoble; 2014. Available from: http://www.theses.fr/2014GRENI014

Université Paris-Sud – Paris XI

26. Keita, Massaba. Conception, synthèse et évaluation biologique d'inhibiteurs fluorés non covalents du protéasome : Design, synthesis and biological test of fluorine non covalent protéasome inhibitors.

Degree: Docteur es, Chimie médicinale, 2012, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2012PA114859

► Le protéasome 26S est une macromolécule impliquée dans la dégradation de la majorité des protéines cellulaires. Parmi ces protéines, il y a les différents régulateurs… (more)

▼ Le protéasome 26S est une macromolécule impliquée dans la dégradation de la majorité des protéines cellulaires. Parmi ces protéines, il y a les différents régulateurs de processus cruciaux tels que les protéines responsables de la progression du cycle cellulaire, de l’apoptose, des réponses inflammatoires, de l’activation de NF-B, de la présentation antigénique et de la différenciation cellulaire. Par conséquent, les inhibiteurs du protéasome sont des agents thérapeutiques dans des pathologies tels que le cancer, l’inflammation et les maladies auto-immunes. En effet, les inhibiteurs du protéasome sont connus pour induire la mort sélective des cellules cancéreuses tout en les rendant plus sensibles aux autres traitements anticancéreux existants (chimiothérapie, radiothérapie…). L’objectif de notre laboratoire est de développer des inhibiteurs non covalents du protéasome de structures peptidomimétiques fluorés ou non fluorés, et de montrer l’intérêt du fluor en chimie médicinale. Mon projet de thèse s’inscrit dans ce cadre. Dans un premier temps nous avons mis en évidence la grande diversité et la quantité des inhibiteurs du protéasome montrant ainsi l’importance de cette macromolécule comme cible dans le traitement du cancer. D’ailleurs, deux de ces inhibiteurs sont utilisés dans le traitement du myélome multiple et du lymphome du manteau et, plusieurs composés sont en études cliniques pour différents cancers. Nous avons aussi mis en évidence le bénéfice apporté par l’incorporation de groupement fluoré sur une molécule bioactive en particulier dans les structures peptidomimétiques. En revanche, ce rappel bibliographique a aussi montré que les peptidomimétiques contraints et fluorés sont peu décrits dans la littérature et le seul exemple à notre connaissance est l’analogue contraint et fluoré de la substance P contenant le motif (Z)-fluoroalcène.La deuxième partie de ces travaux de thèse s’est focalisée sur la conception, la synthèse et l’évaluation biologique d’inhibiteurs originaux du protéasome. Nous avons mis au point une synthèse facile et efficace de pseudopeptides possédant les motifs α et β-hydrazino acides et le motif β-hydrazino acide trifluorométhyle (schéma 1). Ces molécules inhibent de manière efficace le site CT-L du protéasome du lapin avec une IC50 de l’ordre du submicromolaire. Nous avons ainsi démontré que l’activité biologique est maintenue en remplaçant un α-amino acide par un scaffold α ou β-hydrazino acide. La pharmacomodulation effectuée autour de ces motifs nous a permis d’établir des relations structure-activité. Nous avons aussi mis au point un modèle de docking assez fiable qui va nous permettre de prédire le potentiel inhibiteur de nos futures molécules.Enfin, nous avons déterminé l’IC50 de nos molécules en utilisant la technique du FABS en RMN du 19F. Schéma1: voies d’accès aux peptidomimétiques contenant les motifs α et β-hydrazino acide et le motif β-hydrazino acide trifluorométhyl.Ces travaux de thèses ont été complétés par une méthodologie de synthèse portant sur le développement de… Advisors/Committee Members: Ongeri, Sandrine (thesis director).

Subjects/Keywords: Protéasome; Inhibiteurs non covalents; Peptidomimétiques; Fluor; Cyclopropane; N-aminoaziridine; RMN du 19F; Proteasome; Non covalent inhibitors; Peptidomimetics; Fluorine; Cyclopropane; N-aminoaziridine; 19 F NMR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keita, M. (2012). Conception, synthèse et évaluation biologique d'inhibiteurs fluorés non covalents du protéasome : Design, synthesis and biological test of fluorine non covalent protéasome inhibitors. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2012PA114859

Chicago Manual of Style (16^th Edition):

Keita, Massaba. “Conception, synthèse et évaluation biologique d'inhibiteurs fluorés non covalents du protéasome : Design, synthesis and biological test of fluorine non covalent protéasome inhibitors.” 2012. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed February 25, 2021. http://www.theses.fr/2012PA114859.

MLA Handbook (7^th Edition):

Keita, Massaba. “Conception, synthèse et évaluation biologique d'inhibiteurs fluorés non covalents du protéasome : Design, synthesis and biological test of fluorine non covalent protéasome inhibitors.” 2012. Web. 25 Feb 2021.

Vancouver:

Keita M. Conception, synthèse et évaluation biologique d'inhibiteurs fluorés non covalents du protéasome : Design, synthesis and biological test of fluorine non covalent protéasome inhibitors. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2012. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2012PA114859.

Council of Science Editors:

Keita M. Conception, synthèse et évaluation biologique d'inhibiteurs fluorés non covalents du protéasome : Design, synthesis and biological test of fluorine non covalent protéasome inhibitors. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2012. Available from: http://www.theses.fr/2012PA114859

Virginia Tech

27. Clements, Joseph Shelby II. Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, and Elucidation of Regiochemistry and Conformational Isomerism by NMR Spectroscopy and Computation.

Degree: PhD, Chemistry, 2017, Virginia Tech

URL: http://hdl.handle.net/10919/77918

► Based on the success of diacyl-tert-butylhydrazines RH-5849 and RH-1266 in controlling agricultural crop pests, we endeavored to synthesize our own diacylbenzyl- and arylhydrazine derivatives for… (more)

▼ Based on the success of diacyl-tert-butylhydrazines RH-5849 and RH-1266 in controlling agricultural crop pests, we endeavored to synthesize our own diacylbenzyl- and arylhydrazine derivatives for use against the malaria vector Anopheles gambiae. In the process of producing a library of compounds for assay against An. gambiae, it became clear that employing regioselective acylation techniques (in molecules that feature two nucleophilic, acyclic nitrogen atoms α to one another) would be imperative. Synthesis of the library derivatives proceeded rapidly and after topical assay, we found three compounds that were more toxic than the RH-series leads. One of the three displayed an LD50 value of half that of RH-1266, though patch clamp assay concluded that toxicity was not necessarily linked to inhibition of mosquito K+ channel Kv2.1. The acylation of monoarylhydrazines appears simple, but its regioselectivity is poorly understood when assumed as a function of basicity correlating to nucleophilic strength. We determined the ratio of the rate constants for distal to proximal N-acylation using 19F NMR spectroscopic analysis of reactions of 4-fluorophenylhydrazine with limiting (0.2 equiv) acylating agent in the presence of various bases. Acid anhydrides gave consistent preference for distal acylation. The selectivity of acylation by acyl chlorides when using pyridine gives strong distal preference, whereas use of triethylamine or aqueous base in conjunction with aroyl chlorides showed a moderate preference for proximal acylation. This observation yielded a convenient one-step method to synthesize proximal aroylarylhydrazines in yields comparable or superior to that provided by the standard three-step literature approach. Combined with NMR evidence of the distal nitrogen as the unambigiously stronger base of the two nitrogens, we propose a single electron transfer mechanism that predicts the regiochemistry of arylhydrazines toward acylating agents better than the nucleophilicity model based on pKa values. While synthesizing the acylhydrazine library for assay against An. gambiae, NMR spectroscopy revealed rotational isomerisms of two types: chiral helicity (M)/(P) and acyl (E)/(Z)-isomerism due to hindered rotation. Variable temperature NMR allowed the measurement of N-N bond rotational barriers, as well as estimate the barrier of (E)/(Z) interconversion. We obtained the X-ray crystal structures of four diacylhydrazines to test this hypothesis and revealed both the twist conformation around the N-N bond axis and (E)/(Z)-isomerism around the proximal acyl group. Computation (which agreed with the crystal structures) allowed us to estimate which (E)/(Z)-isomers were most likely being observed in solution at room temperature by NMR spectroscopy. In addition, we were able to calculate transition structures corresponding to N-N bond rotational barriers of (E,Z)- and (Z,Z)-isomers of model molecules and rationalize the difference in coalescence temperatures between (E,Z)- and (Z,Z)-isomers. Advisors/Committee Members: Carlier, Paul R. (committeechair), Kingston, David G. I. (committee member), Tanko, James M. (committee member), Yee, Gordon T. (committee member).

Subjects/Keywords: Hydrazine; acylation; α-effect; regioselectivity; hydrazide; voltage-gated; (E)-/(Z)-; 19F NMR; single electron transfer (SET); rotational barrier; N-N bond rotation; rotational isomerism; helicity; transition state; dihedral angle

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clements, J. S. I. (2017). Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, and Elucidation of Regiochemistry and Conformational Isomerism by NMR Spectroscopy and Computation. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77918

Chicago Manual of Style (16^th Edition):

Clements, Joseph Shelby II. “Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, and Elucidation of Regiochemistry and Conformational Isomerism by NMR Spectroscopy and Computation.” 2017. Doctoral Dissertation, Virginia Tech. Accessed February 25, 2021. http://hdl.handle.net/10919/77918.

MLA Handbook (7^th Edition):

Clements, Joseph Shelby II. “Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, and Elucidation of Regiochemistry and Conformational Isomerism by NMR Spectroscopy and Computation.” 2017. Web. 25 Feb 2021.

Vancouver:

Clements JSI. Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, and Elucidation of Regiochemistry and Conformational Isomerism by NMR Spectroscopy and Computation. [Internet] [Doctoral dissertation]. Virginia Tech; 2017. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10919/77918.

Council of Science Editors:

Clements JSI. Synthesis of Insecticidal Mono- and Diacylhydrazines for Disruption of K+ Voltage-Gated Channels, and Elucidation of Regiochemistry and Conformational Isomerism by NMR Spectroscopy and Computation. [Doctoral Dissertation]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/77918

Kyoto University / 京都大学

28. Murayama, Shuuhei. Development of solution NMR method for observation and analysis of proteins inside cells : 核磁気共鳴法による細胞内タンパク質の観測及び手法開発.

Degree: 博士(工学), 2015, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/199327 ; http://dx.doi.org/10.14989/doctor.k19003

新制・課程博士

甲第19003号

工博第4045号

Subjects/Keywords: in-cell NMR; 19F NMR; protein-drug interaction; Amyotrophic lateral sclerosis (ALS); Superoxide dismutase 1 (SOD1); disulfide bond

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APA (6^th Edition):

Murayama, S. (2015). Development of solution NMR method for observation and analysis of proteins inside cells : 核磁気共鳴法による細胞内タンパク質の観測及び手法開発. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/199327 ; http://dx.doi.org/10.14989/doctor.k19003

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Murayama, Shuuhei. “Development of solution NMR method for observation and analysis of proteins inside cells : 核磁気共鳴法による細胞内タンパク質の観測及び手法開発.” 2015. Thesis, Kyoto University / 京都大学. Accessed February 25, 2021. http://hdl.handle.net/2433/199327 ; http://dx.doi.org/10.14989/doctor.k19003.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Murayama, Shuuhei. “Development of solution NMR method for observation and analysis of proteins inside cells : 核磁気共鳴法による細胞内タンパク質の観測及び手法開発.” 2015. Web. 25 Feb 2021.

Vancouver:

Murayama S. Development of solution NMR method for observation and analysis of proteins inside cells : 核磁気共鳴法による細胞内タンパク質の観測及び手法開発. [Internet] [Thesis]. Kyoto University / 京都大学; 2015. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2433/199327 ; http://dx.doi.org/10.14989/doctor.k19003.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Murayama S. Development of solution NMR method for observation and analysis of proteins inside cells : 核磁気共鳴法による細胞内タンパク質の観測及び手法開発. [Thesis]. Kyoto University / 京都大学; 2015. Available from: http://hdl.handle.net/2433/199327 ; http://dx.doi.org/10.14989/doctor.k19003

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kyoto University

29. Murayama, Shuuhei. Development of solution NMR method for observation and analysis of proteins inside cells .

Degree: 2015, Kyoto University

URL: http://hdl.handle.net/2433/199327

Subjects/Keywords: in-cell NMR; 19F NMR; protein-drug interaction; Amyotrophic lateral sclerosis (ALS); Superoxide dismutase 1 (SOD1); disulfide bond

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Murayama, S. (2015). Development of solution NMR method for observation and analysis of proteins inside cells . (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/199327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Murayama, Shuuhei. “Development of solution NMR method for observation and analysis of proteins inside cells .” 2015. Thesis, Kyoto University. Accessed February 25, 2021. http://hdl.handle.net/2433/199327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Murayama, Shuuhei. “Development of solution NMR method for observation and analysis of proteins inside cells .” 2015. Web. 25 Feb 2021.

Vancouver:

Murayama S. Development of solution NMR method for observation and analysis of proteins inside cells . [Internet] [Thesis]. Kyoto University; 2015. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2433/199327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Murayama S. Development of solution NMR method for observation and analysis of proteins inside cells . [Thesis]. Kyoto University; 2015. Available from: http://hdl.handle.net/2433/199327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. 清水, 勇喜. 19F核磁気共鳴を用いた核酸イメージング法の開発.

Degree: Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学

URL: http://hdl.handle.net/10119/9695

Supervisor:藤本健造

マテリアルサイエンス研究科

修士

Subjects/Keywords: 核磁気共鳴法; NMR; 19F; 19F; ガドリニウム; Gd; 常磁性効果; PRE; モレキュラー型プローブ; molecular　probe

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

清水, �. (n.d.). 19F核磁気共鳴を用いた核酸イメージング法の開発. (Thesis). Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10119/9695

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

清水, 勇喜. “19F核磁気共鳴を用いた核酸イメージング法の開発.” Thesis, Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学. Accessed February 25, 2021. http://hdl.handle.net/10119/9695.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

清水, 勇喜. “19F核磁気共鳴を用いた核酸イメージング法の開発.” Web. 25 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

清水 �. 19F核磁気共鳴を用いた核酸イメージング法の開発. [Internet] [Thesis]. Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学; [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10119/9695.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

清水 �. 19F核磁気共鳴を用いた核酸イメージング法の開発. [Thesis]. Japan Advanced Institute of Science and Technology / 北陸先端科学技術大学院大学; Available from: http://hdl.handle.net/10119/9695

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

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Open Access Theses and Dissertations