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You searched for subject:(11q23). Showing records 1 – 3 of 3 total matches.

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NSYSU

1. Chen, Ya-Lan. Molecular Analysis of Myeloid/lymphoid or Mixed lineage Leukemia (MLL) Gene Rearrangement in Acute Myelogenous Leukemia with Normal Cytogenetics.

Degree: Master, Biological Sciences, 2012, NSYSU

Acute myeloid leukemia (AML) is a highly heterogeneous disorder that results from a block in the differentiation of hematopoietic progenitor cells along with uncontrolled proliferation. In approximately 60% of cases, specific recurrent chromosomal aberrations can be identified by modern cytogenetic techniques, and is an important indicator to classify patients into three prognostic categories: favorable, intermediate, and poor risk. Currently, favorable risk patients are usually treated with chemotherapy while poor risk patients receive allogeneic stem cell transplantation. However, the largest subgroup of AML patients (approximately 40%) has no identifiable cytogenetic abnormalities and is classified as intermediate risk. In this special subgroup of patients, a number of studies have demonstrated the relationship between different translocations involving the mixed lineage leukemia (MLL) gene and patient prognosis. The heterogeneity of MLL-rearranged AML is reflected by the identification of more than 70 different fusion partners of this gene and the panel is continuously increasing. The aim of this study is to develop a sensitive molecular profiling test for relevant risk stratification that can help in the decision of treatment and/or follow-up strategy. Advisors/Committee Members: Ching-Mei Hsu (chair), Ming-Hong Tai (committee member), Chung-Liang Ho (chair).

Subjects/Keywords: chromosomal translocations; cytogenetic techniques; prognostic; 11q23; acute myeloid leukemia; mixed lineage leukemia (MLL) gene

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chen, Y. (2012). Molecular Analysis of Myeloid/lymphoid or Mixed lineage Leukemia (MLL) Gene Rearrangement in Acute Myelogenous Leukemia with Normal Cytogenetics. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721112-073036

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Chen, Ya-Lan. “Molecular Analysis of Myeloid/lymphoid or Mixed lineage Leukemia (MLL) Gene Rearrangement in Acute Myelogenous Leukemia with Normal Cytogenetics.” 2012. Thesis, NSYSU. Accessed July 16, 2019. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721112-073036.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Chen, Ya-Lan. “Molecular Analysis of Myeloid/lymphoid or Mixed lineage Leukemia (MLL) Gene Rearrangement in Acute Myelogenous Leukemia with Normal Cytogenetics.” 2012. Web. 16 Jul 2019.

Vancouver:

Chen Y. Molecular Analysis of Myeloid/lymphoid or Mixed lineage Leukemia (MLL) Gene Rearrangement in Acute Myelogenous Leukemia with Normal Cytogenetics. [Internet] [Thesis]. NSYSU; 2012. [cited 2019 Jul 16]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721112-073036.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen Y. Molecular Analysis of Myeloid/lymphoid or Mixed lineage Leukemia (MLL) Gene Rearrangement in Acute Myelogenous Leukemia with Normal Cytogenetics. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721112-073036

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Mattsson, Anna. Difference in copy number variants in peripheral blood and bone marrow detected by SNP-array.

Degree: Biomedical Laboratory Science, 2011, Umeå University

Subjects/Keywords: SNP-array; chromosomes; copy number variants; leukemia; aberrations; 11q23

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mattsson, A. (2011). Difference in copy number variants in peripheral blood and bone marrow detected by SNP-array. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58641

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mattsson, Anna. “Difference in copy number variants in peripheral blood and bone marrow detected by SNP-array.” 2011. Thesis, Umeå University. Accessed July 16, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58641.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mattsson, Anna. “Difference in copy number variants in peripheral blood and bone marrow detected by SNP-array.” 2011. Web. 16 Jul 2019.

Vancouver:

Mattsson A. Difference in copy number variants in peripheral blood and bone marrow detected by SNP-array. [Internet] [Thesis]. Umeå University; 2011. [cited 2019 Jul 16]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58641.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mattsson A. Difference in copy number variants in peripheral blood and bone marrow detected by SNP-array. [Thesis]. Umeå University; 2011. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-58641

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Μπόλλας, Γεώργιος. Μελέτη του MLL γονιδίου σε πρωτοπαθή (de novo) ΜΔΣ.

Degree: 2002, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

The MLL gene has been identified in llq23 translocations and its rearrangement has been associated with acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL), mixed lineage leukemias and infant ALL. It has also been associated with secondary acute leukemias induced by topoisomerase inhibitors. The MLL gene forms fusion transcripts with a variety of partner genes and in the majority of cases the translocation breakpoints lie within an 8.3Kb Bam HI genomic fragment between exons 5 and 9 of the MLL gene. Data in the literature support the concept that MLL gene rearrangements take place at the level of the pluripotent hemopoietic stem cell. Myelodysplastic syndromes constitute a group! of clonal disorders at the level of the pluripotent hematopoietic stem cell resulting in different degree of ineffective hemopoiesis. The aim of the present study is the investigation of the frequency of MLL gene rearrangements in cases of de novo MDS. Patients and methods: 62 patients were included in the analysis: 7 with RA, 4 with RAS, 23 with RAEB, 9 with RAEB-t, 11 with CMML, 1 with hypoplastic MDS, 1 with AML (M6) and 6 with leukemic transformation of preexisting MDS.

Το γονίδιο MLL στη χρωμοσωμική ζώνη llq23 αποτελεί ένα παράγοντα μεταγραφής, που έχει βρεθεί αναδιαταγμένος σε οξείες λεμφοβλαστικές και μυελογενείς λευχαιμίες των ενηλίκων, σε βρεφικές οξείες λευχαιμίες και σε δευτεροπαθείς οξείες λευχαιμίες που προηγουμένως είχαν λάβει θεραπεία με αναστολέα της τοποϊσομεράσης II. Ένα βασικό χαρακτηριστικό των llq23 αντιμεταθέσεων αποτελεί το γεγονός, ότι τα σημεία διάσπασης είναι συγκεντρωμένα σε ένα γενομικό κομμάτι 8,3 Kb Bam HI και περιλαμβάνει τα εξώνια 5-9 του MLL γονιδίου. Σκοπός της παρούσας εργασίας είναι η μελέτη του MLL γονιδίου σε πρωτοπαθή ΜΔΣ, που αποτελούν νόσο του αρχέγονου πολυδύναμου αιμοποιητικού κυττάρου. Μελετήθηκαν 62 ασθενείς με τις ακόλουθες υποκατηγορίες κατά FAB: 7 με RA, 4 με RAS, 23 με RAEB, 9 με RAEB-t, 11 με CMML, 1 ΜΔΣ με υποπλαστικό μυελό, μια περίπτωση ΟΜΛ (Μ6) και 6 με λευχαιμική εκτροπή προϋπάρχοντος ΜΔΣ. Η καρυοτυπική ανάλυση έγινε σύμφωνα με τις κλασσικές μεθόδους. Περιπτώσεις με διαταραχές της ζώνης 1 lq23 μελετήθηκαν με FISH με τη χρήση του ειδικού για το MLL ιχνηλάτη (probe) της ONCOR, σημασμένου με διγοξιγενίνη, ο οποίος ανιχνεύει την πλειοψηφία των αναδιατάξεων του MLL.

Subjects/Keywords: Χρωμοσωμική ζώνη 11q23; Γονίδιο MLL; Μυελοδυσπλαστικά σύνδρομα (MDS); Αναδιατάξεις γονιδίων; Αντιμεταθέσεις; Πρωτοπαθή μυελοδυσπλαστικά σύνδρομα; Myelodysplastic syndromes; MLL; ALL 1; HRX; Htrx-1; 11q23; Gene rearrangements; Translocations; De novo MDS

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Μπόλλας, . . (2002). Μελέτη του MLL γονιδίου σε πρωτοπαθή (de novo) ΜΔΣ. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/21360

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Μπόλλας, Γεώργιος. “Μελέτη του MLL γονιδίου σε πρωτοπαθή (de novo) ΜΔΣ.” 2002. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed July 16, 2019. http://hdl.handle.net/10442/hedi/21360.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Μπόλλας, Γεώργιος. “Μελέτη του MLL γονιδίου σε πρωτοπαθή (de novo) ΜΔΣ.” 2002. Web. 16 Jul 2019.

Vancouver:

Μπόλλας . Μελέτη του MLL γονιδίου σε πρωτοπαθή (de novo) ΜΔΣ. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2002. [cited 2019 Jul 16]. Available from: http://hdl.handle.net/10442/hedi/21360.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Μπόλλας . Μελέτη του MLL γονιδίου σε πρωτοπαθή (de novo) ΜΔΣ. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2002. Available from: http://hdl.handle.net/10442/hedi/21360

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.