subject:(0485)

University of Toronto

1. Badali, Marie Kaitlin. Fate of Atmospheric HOx and Peroxides in the Particle Phase.

Degree: 2014, University of Toronto

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The odd hydrogen radicals hydroxy (OH) and hydroperoxy (HO2), collectively referred to as HOx, along with peroxides, play a significant role in determining the oxidative… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Badali, M. K. (2014). Fate of Atmospheric HOx and Peroxides in the Particle Phase. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/67863

Chicago Manual of Style (16^th Edition):

Badali, Marie Kaitlin. “Fate of Atmospheric HOx and Peroxides in the Particle Phase.” 2014. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/67863.

MLA Handbook (7^th Edition):

Badali, Marie Kaitlin. “Fate of Atmospheric HOx and Peroxides in the Particle Phase.” 2014. Web. 22 Jan 2021.

Vancouver:

Badali MK. Fate of Atmospheric HOx and Peroxides in the Particle Phase. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/67863.

Council of Science Editors:

Badali MK. Fate of Atmospheric HOx and Peroxides in the Particle Phase. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/67863

University of Toronto

2. Gendron-Herndon, Celia. Ruthenium-Diazafluorenide Complexes for Catalysis of Oxa-Michael Addition Reactions.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/70422

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Recent studies in the field of organometallic catalysis have explored metal-ligand cooperativity in the catalysis of oxa-Michael addition reactions. The ligand-based reactivity of ruthenium-diazafluorenide complexes… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Gendron-Herndon, C. (2015). Ruthenium-Diazafluorenide Complexes for Catalysis of Oxa-Michael Addition Reactions. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70422

Chicago Manual of Style (16^th Edition):

Gendron-Herndon, Celia. “Ruthenium-Diazafluorenide Complexes for Catalysis of Oxa-Michael Addition Reactions.” 2015. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/70422.

MLA Handbook (7^th Edition):

Gendron-Herndon, Celia. “Ruthenium-Diazafluorenide Complexes for Catalysis of Oxa-Michael Addition Reactions.” 2015. Web. 22 Jan 2021.

Vancouver:

Gendron-Herndon C. Ruthenium-Diazafluorenide Complexes for Catalysis of Oxa-Michael Addition Reactions. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/70422.

Council of Science Editors:

Gendron-Herndon C. Ruthenium-Diazafluorenide Complexes for Catalysis of Oxa-Michael Addition Reactions. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/70422

University of Toronto

3. Zaichuk, Sonia. Chiral Diene/Phosphine Hybrid Ligands: Synthesis Applications.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/71444

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The Lautens group has recently developed a variety of novel multi-metal catalyzed synthetic methodologies involving chiral and achiral ligands. These types of systems are attractive… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Zaichuk, S. (2015). Chiral Diene/Phosphine Hybrid Ligands: Synthesis Applications. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/71444

Chicago Manual of Style (16^th Edition):

Zaichuk, Sonia. “Chiral Diene/Phosphine Hybrid Ligands: Synthesis Applications.” 2015. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/71444.

MLA Handbook (7^th Edition):

Zaichuk, Sonia. “Chiral Diene/Phosphine Hybrid Ligands: Synthesis Applications.” 2015. Web. 22 Jan 2021.

Vancouver:

Zaichuk S. Chiral Diene/Phosphine Hybrid Ligands: Synthesis Applications. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/71444.

Council of Science Editors:

Zaichuk S. Chiral Diene/Phosphine Hybrid Ligands: Synthesis Applications. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/71444

University of Toronto

4. Kaur Mahrok, Anjan Preet. Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/72372

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There is limited information on the properties of benzotellurophenes and platinum diethynyl chalcogenophene polymers in the literature. The first chapter of the thesis details investigation… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Kaur Mahrok, A. P. (2014). Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/72372

Chicago Manual of Style (16^th Edition):

Kaur Mahrok, Anjan Preet. “Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers.” 2014. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/72372.

MLA Handbook (7^th Edition):

Kaur Mahrok, Anjan Preet. “Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers.” 2014. Web. 22 Jan 2021.

Vancouver:

Kaur Mahrok AP. Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/72372.

Council of Science Editors:

Kaur Mahrok AP. Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/72372

University of Toronto

5. Kaur Mahrok, Anjan Preet. Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/72381

►

There is limited information on the properties of benzotellurophenes and platinum diethynyl chalcogenophene polymers in the literature. The first chapter of the thesis details investigation… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Kaur Mahrok, A. P. (2014). Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/72381

Chicago Manual of Style (16^th Edition):

Kaur Mahrok, Anjan Preet. “Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers.” 2014. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/72381.

MLA Handbook (7^th Edition):

Kaur Mahrok, Anjan Preet. “Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers.” 2014. Web. 22 Jan 2021.

Vancouver:

Kaur Mahrok AP. Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/72381.

Council of Science Editors:

Kaur Mahrok AP. Fundamental Studies on Benzotellurophenes and Platinum Diethynyl Chalcogenophene Polymers. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/72381

University of Toronto

6. Jouk, Andriana Olga. Targeting Clinically Viable Protein Tyrosine Phosphatases with Rationally Designed, Small Molecule Inhibitors and Artificially Induced Protein-Membrane Anchors.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/74627

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Protein tyrosine phosphatases (PTPs) regulate the phosphorylation state of many important signaling molecules and are increasingly viewed as integral components of signal transduction cascades. PTPs… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Jouk, A. O. (2014). Targeting Clinically Viable Protein Tyrosine Phosphatases with Rationally Designed, Small Molecule Inhibitors and Artificially Induced Protein-Membrane Anchors. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74627

Chicago Manual of Style (16^th Edition):

Jouk, Andriana Olga. “Targeting Clinically Viable Protein Tyrosine Phosphatases with Rationally Designed, Small Molecule Inhibitors and Artificially Induced Protein-Membrane Anchors.” 2014. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/74627.

MLA Handbook (7^th Edition):

Jouk, Andriana Olga. “Targeting Clinically Viable Protein Tyrosine Phosphatases with Rationally Designed, Small Molecule Inhibitors and Artificially Induced Protein-Membrane Anchors.” 2014. Web. 22 Jan 2021.

Vancouver:

Jouk AO. Targeting Clinically Viable Protein Tyrosine Phosphatases with Rationally Designed, Small Molecule Inhibitors and Artificially Induced Protein-Membrane Anchors. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/74627.

Council of Science Editors:

Jouk AO. Targeting Clinically Viable Protein Tyrosine Phosphatases with Rationally Designed, Small Molecule Inhibitors and Artificially Induced Protein-Membrane Anchors. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/74627

University of Toronto

7. Al-Faouri, Tamara. Silica Encapsulated Gold Nanoparticles as SERS Labels for the Detection of Lymphoma B-Cells in Tissue Sections.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/75756

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The surface of silica encapsulated gold nanoparticles with trans-1,2-bis (4-pyridyl) ethylene Raman active dye were utilized as SERS labels to target CD20 surface protein on… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Al-Faouri, T. (2015). Silica Encapsulated Gold Nanoparticles as SERS Labels for the Detection of Lymphoma B-Cells in Tissue Sections. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/75756

Chicago Manual of Style (16^th Edition):

Al-Faouri, Tamara. “Silica Encapsulated Gold Nanoparticles as SERS Labels for the Detection of Lymphoma B-Cells in Tissue Sections.” 2015. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/75756.

MLA Handbook (7^th Edition):

Al-Faouri, Tamara. “Silica Encapsulated Gold Nanoparticles as SERS Labels for the Detection of Lymphoma B-Cells in Tissue Sections.” 2015. Web. 22 Jan 2021.

Vancouver:

Al-Faouri T. Silica Encapsulated Gold Nanoparticles as SERS Labels for the Detection of Lymphoma B-Cells in Tissue Sections. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/75756.

Council of Science Editors:

Al-Faouri T. Silica Encapsulated Gold Nanoparticles as SERS Labels for the Detection of Lymphoma B-Cells in Tissue Sections. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/75756

University of Toronto

8. Alwarda, Ramina. Direct Analysis of Trace Contaminants on Indoor Surfaces and their Loss via Reaction with Hydroxyl Radicals.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/93248

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It is well known that semivolatile organic compounds (SVOCs) are persistent indoors and can sorb onto surfaces creating organic films. Most previous studies on indoor… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Alwarda, R. (2017). Direct Analysis of Trace Contaminants on Indoor Surfaces and their Loss via Reaction with Hydroxyl Radicals. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/93248

Chicago Manual of Style (16^th Edition):

Alwarda, Ramina. “Direct Analysis of Trace Contaminants on Indoor Surfaces and their Loss via Reaction with Hydroxyl Radicals.” 2017. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/93248.

MLA Handbook (7^th Edition):

Alwarda, Ramina. “Direct Analysis of Trace Contaminants on Indoor Surfaces and their Loss via Reaction with Hydroxyl Radicals.” 2017. Web. 22 Jan 2021.

Vancouver:

Alwarda R. Direct Analysis of Trace Contaminants on Indoor Surfaces and their Loss via Reaction with Hydroxyl Radicals. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/93248.

Council of Science Editors:

Alwarda R. Direct Analysis of Trace Contaminants on Indoor Surfaces and their Loss via Reaction with Hydroxyl Radicals. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/93248

University of Toronto

9. Kolaj, Igri. Design, Synthesis and Biological Assessment of Ferulic Acid Derivatives as Inhibitors of β-Amyloid Oligomerization in Alzheimer’s Disease.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/93249

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Alzheimer’s disease (AD) is a progressive neurological disorder that arises from the abnormal folding of β-amyloid (Aβ) and its subsequent aggregation. The resulting oligomers are… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Kolaj, I. (2017). Design, Synthesis and Biological Assessment of Ferulic Acid Derivatives as Inhibitors of β-Amyloid Oligomerization in Alzheimer’s Disease. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/93249

Chicago Manual of Style (16^th Edition):

Kolaj, Igri. “Design, Synthesis and Biological Assessment of Ferulic Acid Derivatives as Inhibitors of β-Amyloid Oligomerization in Alzheimer’s Disease.” 2017. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/93249.

MLA Handbook (7^th Edition):

Kolaj, Igri. “Design, Synthesis and Biological Assessment of Ferulic Acid Derivatives as Inhibitors of β-Amyloid Oligomerization in Alzheimer’s Disease.” 2017. Web. 22 Jan 2021.

Vancouver:

Kolaj I. Design, Synthesis and Biological Assessment of Ferulic Acid Derivatives as Inhibitors of β-Amyloid Oligomerization in Alzheimer’s Disease. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/93249.

Council of Science Editors:

Kolaj I. Design, Synthesis and Biological Assessment of Ferulic Acid Derivatives as Inhibitors of β-Amyloid Oligomerization in Alzheimer’s Disease. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/93249

University of Toronto

10. Lam, Jolie. Boron-based Lewis Acids: Towards Intramolecular Frustrated Lewis Pairs and Enantioselective Catalysis.

Degree: PhD, 2020, University of Toronto

URL: http://hdl.handle.net/1807/101331

► A rapid development of metal-free, main group compounds for small molecule activation and as hydrogenation catalysts was triggered after the disclosure of H2 activation by… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Lam, J. (2020). Boron-based Lewis Acids: Towards Intramolecular Frustrated Lewis Pairs and Enantioselective Catalysis. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/101331

Chicago Manual of Style (16^th Edition):

Lam, Jolie. “Boron-based Lewis Acids: Towards Intramolecular Frustrated Lewis Pairs and Enantioselective Catalysis.” 2020. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/101331.

MLA Handbook (7^th Edition):

Lam, Jolie. “Boron-based Lewis Acids: Towards Intramolecular Frustrated Lewis Pairs and Enantioselective Catalysis.” 2020. Web. 22 Jan 2021.

Vancouver:

Lam J. Boron-based Lewis Acids: Towards Intramolecular Frustrated Lewis Pairs and Enantioselective Catalysis. [Internet] [Doctoral dissertation]. University of Toronto; 2020. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/101331.

Council of Science Editors:

Lam J. Boron-based Lewis Acids: Towards Intramolecular Frustrated Lewis Pairs and Enantioselective Catalysis. [Doctoral Dissertation]. University of Toronto; 2020. Available from: http://hdl.handle.net/1807/101331

University of Toronto

11. Ward, Robert Massey. Synthesis and Glycosylation of Various Ceramide Derivatives via Borinic Acid Catalysis.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/79139

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Glycosphingolipids (GSLs) have become of increased interest due to recent realization that they may place a role in neurological diseases and cancer. Chemical synthesis of… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Ward, R. M. (2017). Synthesis and Glycosylation of Various Ceramide Derivatives via Borinic Acid Catalysis. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/79139

Chicago Manual of Style (16^th Edition):

Ward, Robert Massey. “Synthesis and Glycosylation of Various Ceramide Derivatives via Borinic Acid Catalysis.” 2017. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/79139.

MLA Handbook (7^th Edition):

Ward, Robert Massey. “Synthesis and Glycosylation of Various Ceramide Derivatives via Borinic Acid Catalysis.” 2017. Web. 22 Jan 2021.

Vancouver:

Ward RM. Synthesis and Glycosylation of Various Ceramide Derivatives via Borinic Acid Catalysis. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/79139.

Council of Science Editors:

Ward RM. Synthesis and Glycosylation of Various Ceramide Derivatives via Borinic Acid Catalysis. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/79139

University of Toronto

12. El Sheikh, Mariam Zakaria. Studies towards the Development of a DART-MS Based Assay to Study the Kinetics of PgaB, a de-N-acetylase Essential for Biofilm Formation.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/79709

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Bacterial biofilms are surface-attached microbial communities embedded in an extracellular matrix. The extracellular matrix of many infectious bacterial strains contains partially de-N-acetylated Î˛-(1,6)-N-acetylglucosamine polymers (dPNAG).… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

El Sheikh, M. Z. (2016). Studies towards the Development of a DART-MS Based Assay to Study the Kinetics of PgaB, a de-N-acetylase Essential for Biofilm Formation. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/79709

Chicago Manual of Style (16^th Edition):

El Sheikh, Mariam Zakaria. “Studies towards the Development of a DART-MS Based Assay to Study the Kinetics of PgaB, a de-N-acetylase Essential for Biofilm Formation.” 2016. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/79709.

MLA Handbook (7^th Edition):

El Sheikh, Mariam Zakaria. “Studies towards the Development of a DART-MS Based Assay to Study the Kinetics of PgaB, a de-N-acetylase Essential for Biofilm Formation.” 2016. Web. 22 Jan 2021.

Vancouver:

El Sheikh MZ. Studies towards the Development of a DART-MS Based Assay to Study the Kinetics of PgaB, a de-N-acetylase Essential for Biofilm Formation. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/79709.

Council of Science Editors:

El Sheikh MZ. Studies towards the Development of a DART-MS Based Assay to Study the Kinetics of PgaB, a de-N-acetylase Essential for Biofilm Formation. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/79709

University of Toronto

13. Collins, Catherine Victoria H. Towards Red Light Control of Ion Channel Blockers.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/79828

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Photoswitchable ion channel blockers reported previously have proven effective for modulating the activity of voltage-gated potassium (KV) channels. One limitation of previously reported azobenzene-based blockers… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Collins, C. V. H. (2016). Towards Red Light Control of Ion Channel Blockers. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/79828

Chicago Manual of Style (16^th Edition):

Collins, Catherine Victoria H. “Towards Red Light Control of Ion Channel Blockers.” 2016. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/79828.

MLA Handbook (7^th Edition):

Collins, Catherine Victoria H. “Towards Red Light Control of Ion Channel Blockers.” 2016. Web. 22 Jan 2021.

Vancouver:

Collins CVH. Towards Red Light Control of Ion Channel Blockers. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/79828.

Council of Science Editors:

Collins CVH. Towards Red Light Control of Ion Channel Blockers. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/79828

University of Toronto

14. Kim, Jung Yun. Multicomponent One-pot One-step Synthesis of 1,2,3-Triazoles via Cu/Pd Catalysis.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/80250

►

In modern synthetic chemistry, the formation of multiple C-C bonds in a limited number of steps to access both diversity and complexity has become an… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Kim, J. Y. (2014). Multicomponent One-pot One-step Synthesis of 1,2,3-Triazoles via Cu/Pd Catalysis. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/80250

Chicago Manual of Style (16^th Edition):

Kim, Jung Yun. “Multicomponent One-pot One-step Synthesis of 1,2,3-Triazoles via Cu/Pd Catalysis.” 2014. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/80250.

MLA Handbook (7^th Edition):

Kim, Jung Yun. “Multicomponent One-pot One-step Synthesis of 1,2,3-Triazoles via Cu/Pd Catalysis.” 2014. Web. 22 Jan 2021.

Vancouver:

Kim JY. Multicomponent One-pot One-step Synthesis of 1,2,3-Triazoles via Cu/Pd Catalysis. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/80250.

Council of Science Editors:

Kim JY. Multicomponent One-pot One-step Synthesis of 1,2,3-Triazoles via Cu/Pd Catalysis. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/80250

University of Toronto

15. Sriskandha, Shivanthi Easwari. Properties and Structure of Cellulose Nanocrystal Hydrogels for Potential Applications as Three-dimensional Artificial Extracellular Matrices.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/69546

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This thesis describes the preparation of hydrogels of cellulose nanocrystals (CNCs) into environments that would support the growth of cells either by (i) adding Hank's… (more)

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APA (6^th Edition):

Sriskandha, S. E. (2015). Properties and Structure of Cellulose Nanocrystal Hydrogels for Potential Applications as Three-dimensional Artificial Extracellular Matrices. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/69546

Chicago Manual of Style (16^th Edition):

Sriskandha, Shivanthi Easwari. “Properties and Structure of Cellulose Nanocrystal Hydrogels for Potential Applications as Three-dimensional Artificial Extracellular Matrices.” 2015. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/69546.

MLA Handbook (7^th Edition):

Sriskandha, Shivanthi Easwari. “Properties and Structure of Cellulose Nanocrystal Hydrogels for Potential Applications as Three-dimensional Artificial Extracellular Matrices.” 2015. Web. 22 Jan 2021.

Vancouver:

Sriskandha SE. Properties and Structure of Cellulose Nanocrystal Hydrogels for Potential Applications as Three-dimensional Artificial Extracellular Matrices. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/69546.

Council of Science Editors:

Sriskandha SE. Properties and Structure of Cellulose Nanocrystal Hydrogels for Potential Applications as Three-dimensional Artificial Extracellular Matrices. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69546

University of Toronto

16. Rana, Rahul. Resistance and Binding Profile of Cabozantinib, a ROS1 Inhibitor and Design of Peptidomimetic Inhibitors of STAT5 Protein.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/72767

►

Genes encoding for tyrosine kinases that undergo rearrangement at chromosomal breakpoints have been associated with constitutively activated transcript products. Repressor of silencing 1 (ROS1) tyrosine… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Rana, R. (2016). Resistance and Binding Profile of Cabozantinib, a ROS1 Inhibitor and Design of Peptidomimetic Inhibitors of STAT5 Protein. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/72767

Chicago Manual of Style (16^th Edition):

Rana, Rahul. “Resistance and Binding Profile of Cabozantinib, a ROS1 Inhibitor and Design of Peptidomimetic Inhibitors of STAT5 Protein.” 2016. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/72767.

MLA Handbook (7^th Edition):

Rana, Rahul. “Resistance and Binding Profile of Cabozantinib, a ROS1 Inhibitor and Design of Peptidomimetic Inhibitors of STAT5 Protein.” 2016. Web. 22 Jan 2021.

Vancouver:

Rana R. Resistance and Binding Profile of Cabozantinib, a ROS1 Inhibitor and Design of Peptidomimetic Inhibitors of STAT5 Protein. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/72767.

Council of Science Editors:

Rana R. Resistance and Binding Profile of Cabozantinib, a ROS1 Inhibitor and Design of Peptidomimetic Inhibitors of STAT5 Protein. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/72767

University of Toronto

17. Ravindranath, Rohan Raghav. Investigating the Use of a Biologically Active Surface Coating for Coronary Stent Devices: A New Approach to Improving Biocompatibility.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/72776

►

Coronary artery disease is a major cause of death globally, and has led to the use of medical implants like coronary stents. Unfortunately, re-narrowing of… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Ravindranath, R. R. (2016). Investigating the Use of a Biologically Active Surface Coating for Coronary Stent Devices: A New Approach to Improving Biocompatibility. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/72776

Chicago Manual of Style (16^th Edition):

Ravindranath, Rohan Raghav. “Investigating the Use of a Biologically Active Surface Coating for Coronary Stent Devices: A New Approach to Improving Biocompatibility.” 2016. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/72776.

MLA Handbook (7^th Edition):

Ravindranath, Rohan Raghav. “Investigating the Use of a Biologically Active Surface Coating for Coronary Stent Devices: A New Approach to Improving Biocompatibility.” 2016. Web. 22 Jan 2021.

Vancouver:

Ravindranath RR. Investigating the Use of a Biologically Active Surface Coating for Coronary Stent Devices: A New Approach to Improving Biocompatibility. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/72776.

Council of Science Editors:

Ravindranath RR. Investigating the Use of a Biologically Active Surface Coating for Coronary Stent Devices: A New Approach to Improving Biocompatibility. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/72776

University of Toronto

18. Sooklal, Clarissa Rana. Phosphorylation-dependent structural changes in the N-terminal extension of SUR2A NBD1.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/74465

►

ATP-sensitive potassium (KATP) channels are involved in many biological processes and play an important role in sustaining healthy functioning organs. KATP channels are composed of… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Sooklal, C. R. (2015). Phosphorylation-dependent structural changes in the N-terminal extension of SUR2A NBD1. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74465

Chicago Manual of Style (16^th Edition):

Sooklal, Clarissa Rana. “Phosphorylation-dependent structural changes in the N-terminal extension of SUR2A NBD1.” 2015. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/74465.

MLA Handbook (7^th Edition):

Sooklal, Clarissa Rana. “Phosphorylation-dependent structural changes in the N-terminal extension of SUR2A NBD1.” 2015. Web. 22 Jan 2021.

Vancouver:

Sooklal CR. Phosphorylation-dependent structural changes in the N-terminal extension of SUR2A NBD1. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/74465.

Council of Science Editors:

Sooklal CR. Phosphorylation-dependent structural changes in the N-terminal extension of SUR2A NBD1. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/74465

University of Toronto

19. Strtak, Alexandra. Exploring Evolution: I. Directing Evolution of Proteins with Phage, II. Examining the Effects of Toxic Quantum Dots on the Yeast Genome.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/74467

►

This thesis comprises two separate directed evolution studies. Part I describes the optimization of a reporter construct for the protein evolution tool, PACE. Myc is… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Strtak, A. (2015). Exploring Evolution: I. Directing Evolution of Proteins with Phage, II. Examining the Effects of Toxic Quantum Dots on the Yeast Genome. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74467

Chicago Manual of Style (16^th Edition):

Strtak, Alexandra. “Exploring Evolution: I. Directing Evolution of Proteins with Phage, II. Examining the Effects of Toxic Quantum Dots on the Yeast Genome.” 2015. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/74467.

MLA Handbook (7^th Edition):

Strtak, Alexandra. “Exploring Evolution: I. Directing Evolution of Proteins with Phage, II. Examining the Effects of Toxic Quantum Dots on the Yeast Genome.” 2015. Web. 22 Jan 2021.

Vancouver:

Strtak A. Exploring Evolution: I. Directing Evolution of Proteins with Phage, II. Examining the Effects of Toxic Quantum Dots on the Yeast Genome. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/74467.

Council of Science Editors:

Strtak A. Exploring Evolution: I. Directing Evolution of Proteins with Phage, II. Examining the Effects of Toxic Quantum Dots on the Yeast Genome. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/74467

University of Toronto

20. Cheung, Cynthia. Organic Materials as Charge Transport Layers: A Relationship Strengthened by the Chemistry of PEDOT:PSS and Hemiporphyrazine Derivatives.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/95633

►

The aim of this thesis was to study and develop new charge transport materials for the application of organic photovoltaic (OPV) devices. The hole-transport material… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Cheung, C. (2018). Organic Materials as Charge Transport Layers: A Relationship Strengthened by the Chemistry of PEDOT:PSS and Hemiporphyrazine Derivatives. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/95633

Chicago Manual of Style (16^th Edition):

Cheung, Cynthia. “Organic Materials as Charge Transport Layers: A Relationship Strengthened by the Chemistry of PEDOT:PSS and Hemiporphyrazine Derivatives.” 2018. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/95633.

MLA Handbook (7^th Edition):

Cheung, Cynthia. “Organic Materials as Charge Transport Layers: A Relationship Strengthened by the Chemistry of PEDOT:PSS and Hemiporphyrazine Derivatives.” 2018. Web. 22 Jan 2021.

Vancouver:

Cheung C. Organic Materials as Charge Transport Layers: A Relationship Strengthened by the Chemistry of PEDOT:PSS and Hemiporphyrazine Derivatives. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/95633.

Council of Science Editors:

Cheung C. Organic Materials as Charge Transport Layers: A Relationship Strengthened by the Chemistry of PEDOT:PSS and Hemiporphyrazine Derivatives. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/95633

University of Toronto

21. Escobar, Alex. Lucas-Washburn Flow in the Transverse Dimension of 3D Microfluidic Paper Analytical Devices.

Degree: 2020, University of Toronto

URL: http://hdl.handle.net/1807/103704

►

Microfluidic paper analytical devices (µPADs) are being designed with increasing complexity allowing for a higher density of microfluidic paper functions in a single device. µPADs… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Escobar, A. (2020). Lucas-Washburn Flow in the Transverse Dimension of 3D Microfluidic Paper Analytical Devices. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/103704

Chicago Manual of Style (16^th Edition):

Escobar, Alex. “Lucas-Washburn Flow in the Transverse Dimension of 3D Microfluidic Paper Analytical Devices.” 2020. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/103704.

MLA Handbook (7^th Edition):

Escobar, Alex. “Lucas-Washburn Flow in the Transverse Dimension of 3D Microfluidic Paper Analytical Devices.” 2020. Web. 22 Jan 2021.

Vancouver:

Escobar A. Lucas-Washburn Flow in the Transverse Dimension of 3D Microfluidic Paper Analytical Devices. [Internet] [Masters thesis]. University of Toronto; 2020. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/103704.

Council of Science Editors:

Escobar A. Lucas-Washburn Flow in the Transverse Dimension of 3D Microfluidic Paper Analytical Devices. [Masters Thesis]. University of Toronto; 2020. Available from: http://hdl.handle.net/1807/103704

University of Toronto

22. Dahcheh, Fatme. Carbenes in Ruthenium Based Olefin Metathesis Catalysts and Stabilization of Low Coordinate Boron Species.

Degree: PhD, 2014, University of Toronto

URL: http://hdl.handle.net/1807/68255

► Since their discovery, carbenes have been widely used as organocatalysts and as superb ligands for transition metal-based catalysts. They have also, more recently, been shown… (more)

▼ Since their discovery, carbenes have been widely used as organocatalysts and as superb ligands for transition metal-based catalysts. They have also, more recently, been shown to stabilize reactive and low-valent main group systems. Catalytic olefin metathesis has proven to be a powerful tool in various chemical fields. Research in this area has received considerable attention specifically with the development of new catalysts. The vast majority of catalysts developed, thus far, have been modifications to the Grubbs catalyst architecture. The research presented herein focuses on the development of a new route for the synthesis of new olefin metathesis catalysts and testing their activity. A new method of preparing ruthenium alkylidene complexes starting with bis-carbene RuHCl species and alkenyl sulfides is developed. This provides a route to bis-mixed carbene ruthenium alkylidene complexes with a hemilabile tridentate carbene and conveniently installs both an alkylidene fragment and a thiolate in one step. The resulting Ru-alkylidene are either inactive or minimally active for the standard metathesis tests. The species generated by the addition of one equivalent of BCl3, however, show improved activity for RCM, ROMP and CM either at room temperature or at slightly elevated temperatures. Halide exchange for these systems results in enhanced metathesis activity for the standard tests where catalytic olefin metathesis was observed at room temperature. Cyclic (alkylamino)carbenes are utilized to stabilize iminoboryl moieties which have only been previously stabilized in the coordination sphere of transition metals. Some of the species are also shown to undergo [2+2] cycloaddition with CO2. CAACs are also used for the synthesis of a boron derivative, which is isoelectronic with singlet carbenes, namely a borylene. This species is shown to react with CO and H2, but in contrast with carbenes, it acts as an electrophile and therefore mimics the behavior of metals. Advisors/Committee Members: Douglas, W Stephan, Chemistry.

Subjects/Keywords: 0485

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APA (6^th Edition):

Dahcheh, F. (2014). Carbenes in Ruthenium Based Olefin Metathesis Catalysts and Stabilization of Low Coordinate Boron Species. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/68255

Chicago Manual of Style (16^th Edition):

Dahcheh, Fatme. “Carbenes in Ruthenium Based Olefin Metathesis Catalysts and Stabilization of Low Coordinate Boron Species.” 2014. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/68255.

MLA Handbook (7^th Edition):

Dahcheh, Fatme. “Carbenes in Ruthenium Based Olefin Metathesis Catalysts and Stabilization of Low Coordinate Boron Species.” 2014. Web. 22 Jan 2021.

Vancouver:

Dahcheh F. Carbenes in Ruthenium Based Olefin Metathesis Catalysts and Stabilization of Low Coordinate Boron Species. [Internet] [Doctoral dissertation]. University of Toronto; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/68255.

Council of Science Editors:

Dahcheh F. Carbenes in Ruthenium Based Olefin Metathesis Catalysts and Stabilization of Low Coordinate Boron Species. [Doctoral Dissertation]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/68255

University of Toronto

23. Sonnenberg, Jessica. Mechanistic Insights into Homogeneous and Heterogeneous Asymmetric Iron Catalysis.

Degree: PhD, 2014, University of Toronto

URL: http://hdl.handle.net/1807/68274

► Our group has been focused on replacing toxic and expensive precious metal catalysts with iron for the synthesis of enantiopure compounds for industrial applications. During… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Sonnenberg, J. (2014). Mechanistic Insights into Homogeneous and Heterogeneous Asymmetric Iron Catalysis. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/68274

Chicago Manual of Style (16^th Edition):

Sonnenberg, Jessica. “Mechanistic Insights into Homogeneous and Heterogeneous Asymmetric Iron Catalysis.” 2014. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/68274.

MLA Handbook (7^th Edition):

Sonnenberg, Jessica. “Mechanistic Insights into Homogeneous and Heterogeneous Asymmetric Iron Catalysis.” 2014. Web. 22 Jan 2021.

Vancouver:

Sonnenberg J. Mechanistic Insights into Homogeneous and Heterogeneous Asymmetric Iron Catalysis. [Internet] [Doctoral dissertation]. University of Toronto; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/68274.

Council of Science Editors:

Sonnenberg J. Mechanistic Insights into Homogeneous and Heterogeneous Asymmetric Iron Catalysis. [Doctoral Dissertation]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/68274

University of Toronto

24. Qian, Chenxi. Advances in Silicon Nanocrystals.

Degree: PhD, 2017, University of Toronto

URL: http://hdl.handle.net/1807/79421

► Silicon nanocrystals (ncSi), which are considered as greener alternatives to traditional nanocrystals like CdSe and PbS, offer the benefits of being earth abundant, potentially inexpensive,… (more)

▼ Silicon nanocrystals (ncSi), which are considered as greener alternatives to traditional nanocrystals like CdSe and PbS, offer the benefits of being earth abundant, potentially inexpensive, purportedly less toxic and compatible with silicon electronics. The work presented in this thesis focuses on the contributions in the advances in silicon nanocrystals. This would include developing new synthesis methods for ncSi with simpler precursors and higher yields, exploring new design strategies to enhance the stability and photoluminescence (PL) absolute quantum yield (AQY) of the ncSi, and probing other surface reactions, such as the reduction of gaseous carbon dioxide by the nanosilicon surface hydrides (ncSi:H). Specifically, a batch synthesis based on the thermal solid-state disproportionation of SiO was developed. We managed to pinpoint an optimal temperature range of 850-1100 â , in which the nucleation and growth of ncSi in a SiO2 matrix were observed. More importantly, by implementing this synthetic route, we were able to prepare ncSi with a wider size range and observe directly the size-dependent PL AQY of these ncSi. For the first time we observed optically the both upper and lower critical size at which the quantum size effects (QSE) begin to switch on and switch off, respectively. Apart from this, a major step was taken towards the synthesis of a more stable ncSi ensemble against oxidation by capping the surface with perfluorocarbon chains. Lower rates of oxide shell forming on the ncSi surface was observed and a higher PL AQY was measured for these ensembles. On the other hand, by utilizing the reducing ability of the ncSi surface hydrides, we were able to convert gaseous CO2 selectively to CO, and the observation was unprecedented. The work presented in this thesis has pushed the boundaries of ncSi research, towards a more thorough understanding in the fundamentals and surface chemistry of ncSi. Advisors/Committee Members: Ozin, Geoffrey A, Chemistry.

Subjects/Keywords: 0485

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APA (6^th Edition):

Qian, C. (2017). Advances in Silicon Nanocrystals. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/79421

Chicago Manual of Style (16^th Edition):

Qian, Chenxi. “Advances in Silicon Nanocrystals.” 2017. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/79421.

MLA Handbook (7^th Edition):

Qian, Chenxi. “Advances in Silicon Nanocrystals.” 2017. Web. 22 Jan 2021.

Vancouver:

Qian C. Advances in Silicon Nanocrystals. [Internet] [Doctoral dissertation]. University of Toronto; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/79421.

Council of Science Editors:

Qian C. Advances in Silicon Nanocrystals. [Doctoral Dissertation]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/79421

University of Toronto

25. Li, Yuyang. Metal-Catalyzed Site-Selective Monoacylation with Acyl Phosphate Monoesters in Aqueous Media.

Degree: PhD, 2018, University of Toronto

URL: http://hdl.handle.net/1807/92126

► The development of methods for site-selective aminoacylation of tRNA and site-selective acylation of carbohydrates in water are the central goals of the work in this… (more)

▼ The development of methods for site-selective aminoacylation of tRNA and site-selective acylation of carbohydrates in water are the central goals of the work in this thesis. My general approach focuses on recognition based on the tendency of metal ions to form chelates with cis-diols and with acyl phosphate monoesters. With certain metal ions, both the diol and the acyl phosphate should be able to form bis-bidentate chelates that can undergo internal reactions. In the first section of this thesis, I report site-selective La3+-catalyzed aminoacylation of dinucleotides as a potential route to incorporate unnatural amino acids into proteins. Although enzymatic ligation of the resulting unprotected aminoacyl-dinucleotide to a truncated tRNA-CA requires further development, analysis reveals that the decomposition of acyl phosphate monoesters can be selectively inhibited to increase the yield of the reaction scheme. This improves the efficiency of La3+ catalysis and led to the development of the method with alternative metal ions as catalysts for monoacylation reactions of cis-diols in general. The second section of this thesis describes the development of site-selective aqueous monobenzoylation of polyols and carbohydrates through catalysis by lead salts, presumably by the bis-bidentate chelate. Mechanistic details of the Pb2+-catalyzed process were examined through comparative studies and kinetics. Those results are consistent with the proposed formation of the bis-bidentate chelate of the lead ion and the reaction components. The reaction then proceeds from the complex via catalysis from an internal Brønsted base. The third section describes studies of metal ions and dinuclear metal complexes as potential additional catalysts. Comparative studies were conducted to understand the roles of metal catalysts during the monoacylation process. This section also presents the challenges in the improvement of the methodology. The overall accomplishments in the thesis demonstrate significant advances in the development of site-selective monoacylation of diols and related species in water using acyl phosphate monoesters as donors. The mechanism I propose should provide guidance for developing further work in the area. Advisors/Committee Members: Kluger, Ronald, Chemistry.

Subjects/Keywords: 0485

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APA (6^th Edition):

Li, Y. (2018). Metal-Catalyzed Site-Selective Monoacylation with Acyl Phosphate Monoesters in Aqueous Media. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/92126

Chicago Manual of Style (16^th Edition):

Li, Yuyang. “Metal-Catalyzed Site-Selective Monoacylation with Acyl Phosphate Monoesters in Aqueous Media.” 2018. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/92126.

MLA Handbook (7^th Edition):

Li, Yuyang. “Metal-Catalyzed Site-Selective Monoacylation with Acyl Phosphate Monoesters in Aqueous Media.” 2018. Web. 22 Jan 2021.

Vancouver:

Li Y. Metal-Catalyzed Site-Selective Monoacylation with Acyl Phosphate Monoesters in Aqueous Media. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/92126.

Council of Science Editors:

Li Y. Metal-Catalyzed Site-Selective Monoacylation with Acyl Phosphate Monoesters in Aqueous Media. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/92126

University of Toronto

26. Bayne, Julia Margaret. Highly Electrophilic Phosphorus(V) Cations as Robust Lewis Acids in Catalysis and Frustrated Lewis Pair Chemistry.

Degree: PhD, 2019, University of Toronto

URL: http://hdl.handle.net/1807/97333

► Catalysts are critical to the production of desirable chemicals and materials that are used to manufacture goods which are essential to our modern economy. Efforts… (more)

Subjects/Keywords: 0485

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APA (6^th Edition):

Bayne, J. M. (2019). Highly Electrophilic Phosphorus(V) Cations as Robust Lewis Acids in Catalysis and Frustrated Lewis Pair Chemistry. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/97333

Chicago Manual of Style (16^th Edition):

Bayne, Julia Margaret. “Highly Electrophilic Phosphorus(V) Cations as Robust Lewis Acids in Catalysis and Frustrated Lewis Pair Chemistry.” 2019. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/97333.

MLA Handbook (7^th Edition):

Bayne, Julia Margaret. “Highly Electrophilic Phosphorus(V) Cations as Robust Lewis Acids in Catalysis and Frustrated Lewis Pair Chemistry.” 2019. Web. 22 Jan 2021.

Vancouver:

Bayne JM. Highly Electrophilic Phosphorus(V) Cations as Robust Lewis Acids in Catalysis and Frustrated Lewis Pair Chemistry. [Internet] [Doctoral dissertation]. University of Toronto; 2019. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/97333.

Council of Science Editors:

Bayne JM. Highly Electrophilic Phosphorus(V) Cations as Robust Lewis Acids in Catalysis and Frustrated Lewis Pair Chemistry. [Doctoral Dissertation]. University of Toronto; 2019. Available from: http://hdl.handle.net/1807/97333

University of Toronto

27. Farooq, Hashim. The Development of Environmental Nuclear Magnetic Resonance Spectroscopy for the Study of Structure and Interactions in Complex Environmental Matrices.

Degree: PhD, 2015, University of Toronto

URL: http://hdl.handle.net/1807/89022

►

Elucidating environmental processes at the molecular level is key to understanding a range of larger processes including carbon sequestration and cycling, contaminant transport and fate,… (more)

▼

Elucidating environmental processes at the molecular level is key to understanding a range of larger processes including carbon sequestration and cycling, contaminant transport and fate, and agricultural productivity. Unfortunately, environmental matrices, such as soil, are highly complex, heterogeneous, and often contain multiple phases (liquids, gels and solids) making their analysis by conventional methods challenging. Nuclear Magnetic Resonance (NMR) spectroscopy is arguably one of the most powerful and versatile tools in modern science, with the potential to provide unprecedented levels information as to structures and molecular interactions in complex environmental matrices. Despite this potential NMR is not as widely applied in the environmental research as other fields such as medicine and organic chemistry, in part due to the lack of experimental approaches specifically developed for environmental analysis. This thesis aims to develop a series of fundamental NMR experimental approaches that can improve the reliability, efficiency and information gained from environmental samples. Specifically, it introduces a novel and efficient optimization approach for the determination of fundamental NMR parameters. Following this it develops on a novel approach based on supercooled water to help assign chemical structures in complex mixtures was developed. The method presented enhances intramolecular spatial interactions and uses the resulting spatial correlations to edit mixtures and expands the range of molecules that can be assigned in situ without physical separation of mixtures. Subsequently, it discusses the optimization of high-resolution magic angle spinning (HR-MAS) for environmental samples and allows the transition from the study of static samples (solutions) to those containing more than one phase (liquids and gels). Ultimately while studying solutions and gels in situ is very important to study natural samples holistically in their native state. As such the ability to study all phases (liquids, gels and solids) at the same time is required. This necessitated the development of the comprehensive multiphase technology (CMP), which allows study of all bonds in all phases and is used to paint a molecular-level picture of an oil-contaminated soil along with the aforementioned improvements. The advances shown here in conjunction with CMP technology should prove invaluable in all future studies that require molecular-level information concerning any unaltered complex system.

2018-03-23 00:00:00

Advisors/Committee Members: Simpson, Andre, Chemistry.

Subjects/Keywords: 0485

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APA (6^th Edition):

Farooq, H. (2015). The Development of Environmental Nuclear Magnetic Resonance Spectroscopy for the Study of Structure and Interactions in Complex Environmental Matrices. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89022

Chicago Manual of Style (16^th Edition):

Farooq, Hashim. “The Development of Environmental Nuclear Magnetic Resonance Spectroscopy for the Study of Structure and Interactions in Complex Environmental Matrices.” 2015. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/89022.

MLA Handbook (7^th Edition):

Farooq, Hashim. “The Development of Environmental Nuclear Magnetic Resonance Spectroscopy for the Study of Structure and Interactions in Complex Environmental Matrices.” 2015. Web. 22 Jan 2021.

Vancouver:

Farooq H. The Development of Environmental Nuclear Magnetic Resonance Spectroscopy for the Study of Structure and Interactions in Complex Environmental Matrices. [Internet] [Doctoral dissertation]. University of Toronto; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/89022.

Council of Science Editors:

Farooq H. The Development of Environmental Nuclear Magnetic Resonance Spectroscopy for the Study of Structure and Interactions in Complex Environmental Matrices. [Doctoral Dissertation]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/89022

University of Toronto

28. Vurgun, Nesrin. Access to Versatile β-Cyclodextrin Scaffolds through Guest-mediated Mono-acylation.

Degree: PhD, 2018, University of Toronto

URL: http://hdl.handle.net/1807/89791

► Cyclodextrins (CDs) are naturally occurring macrocyclic oligosaccharides comprised of α-1,4 linked glucose units. CDs are non-toxic and bio-compatible scaffolds. They have a conical structure with… (more)

▼ Cyclodextrins (CDs) are naturally occurring macrocyclic oligosaccharides comprised of α-1,4 linked glucose units. CDs are non-toxic and bio-compatible scaffolds. They have a conical structure with a hydrophobic inner cavity, allowing them to form stable and soluble inclusion complexes with a variety of hydrophobic guest molecules. Furthermore, CDs can be derivatized at the primary or secondary alcohols with a variety of functional groups. Compared to native CDs, derivatized CDs feature a broader range of applications including molecular recognition of small molecules and biomacromolecules, catalysis, supramolecular polymers and targeted drug/DNA delivery. This thesis addresses the hypothesis that highly functionalized cyclodextrins can be accessed via guest-mediated acylation reactions. This thesis explored the development of two methodologies to functionalize heptakis-[6-deoxy-6-(2-aminoethylsulfanyl)]-β-CD, a versatile, amine-functionalized scaffold. The key reaction developed was a selective mono-functionalization of heptakis-[6-deoxy-6-(2-aminoethylsulfanyl)]-β-CD via an acyl transfer reaction proceeding through a covalent-capture mechanism. This approach permitted the installation of a 5-mercaptopentanamide at the primary rim in two steps in high yields. The amine-orthogonal thiol was amenable to functionalization with maleimides or through disulfide exchange. The free thiol also served as a handle for immobilization of the mono-functionalized CD onto solid support for supported synthesis. The functionalization of the primary rim amines of the solid-supported CD, is a rapid and highly modular means to introduce diversity to this scaffold. The combination of these two methodologies afforded access to a library of peptide functionalized CD scaffolds which were modified with environmentally sensitive fluorophores to generate fluorescent receptors. These receptors were applied for the differential sensing of various bile salts, and are currently being investigated for the detection of elevated bile salts in human serum. Advisors/Committee Members: Nitz, Mark, Chemistry.

Subjects/Keywords: 0485

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vurgun, N. (2018). Access to Versatile β-Cyclodextrin Scaffolds through Guest-mediated Mono-acylation. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89791

Chicago Manual of Style (16^th Edition):

Vurgun, Nesrin. “Access to Versatile β-Cyclodextrin Scaffolds through Guest-mediated Mono-acylation.” 2018. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/89791.

MLA Handbook (7^th Edition):

Vurgun, Nesrin. “Access to Versatile β-Cyclodextrin Scaffolds through Guest-mediated Mono-acylation.” 2018. Web. 22 Jan 2021.

Vancouver:

Vurgun N. Access to Versatile β-Cyclodextrin Scaffolds through Guest-mediated Mono-acylation. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/89791.

Council of Science Editors:

Vurgun N. Access to Versatile β-Cyclodextrin Scaffolds through Guest-mediated Mono-acylation. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/89791

University of Toronto

29. Babalhavaeji, Amirhossein. Red-shifted Azobenzenes and Photocontrol of Protein Affinity Reagents.

Degree: PhD, 2018, University of Toronto

URL: http://hdl.handle.net/1807/91793

► Azobenzene derivatives are a class of molecular switches that have found broad use in photocontrol of various biological systems. A key feature of azobenzenes designed… (more)

Subjects/Keywords: 0485

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Babalhavaeji, A. (2018). Red-shifted Azobenzenes and Photocontrol of Protein Affinity Reagents. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/91793

Chicago Manual of Style (16^th Edition):

Babalhavaeji, Amirhossein. “Red-shifted Azobenzenes and Photocontrol of Protein Affinity Reagents.” 2018. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/91793.

MLA Handbook (7^th Edition):

Babalhavaeji, Amirhossein. “Red-shifted Azobenzenes and Photocontrol of Protein Affinity Reagents.” 2018. Web. 22 Jan 2021.

Vancouver:

Babalhavaeji A. Red-shifted Azobenzenes and Photocontrol of Protein Affinity Reagents. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/91793.

Council of Science Editors:

Babalhavaeji A. Red-shifted Azobenzenes and Photocontrol of Protein Affinity Reagents. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91793

University of Toronto

30. Howe, Graeme William. Accelerating Decarboxylation Reactions through the Formation of Bicarbonate.

Degree: PhD, 2016, University of Toronto

URL: http://hdl.handle.net/1807/76468

► Enzyme-catalyzed decarboxylation reactions are often many orders of magnitude faster than the corresponding uncatalyzed processes. In both cases, these reactions are typically represented as the… (more)

▼ Enzyme-catalyzed decarboxylation reactions are often many orders of magnitude faster than the corresponding uncatalyzed processes. In both cases, these reactions are typically represented as the unimolecular decomposition of a carboxylate to a carbanion and CO2. Attempts to understand the catalytic proficiency of decarboxylases generally focus on enzymatic factors that would stabilize the produced carbanion and ignore the released CO2. However, earlier studies have shown that decarboxylation is slowed by internal return of the CO2-carbanion pair. This thesis illustrates how both aqueous and enzymatic decarboxylation reactions can be accelerated by producing alternatives to CO2 that decrease the extent of reversion. This work was initiated by the unexpected observation of general base catalysis in the decarboxylation of mandelylthiamin (MTh), an accurate model of the pre-decarboxylation intermediate formed on benzoylformate decarboxylase (BFDC). This catalysis is inconsistent with the direct production of CO2 from the carboxylate. Instead, detailed kinetic analysis suggests a mechanism involving hydration of the carboxylate and subsequent base-catalyzed decomposition to produce HCO3-. Computational analysis of a model decarboxylation illustrates that this hydrolytic mechanism avoids the issue of internal return. This is consistent with HCO3- being less electrophilic and more water-soluble than CO2 as these properties would facilitate the separation of the carbanion-HCO3- pair. Kinetic and computational studies were also performed with numerous structural analogues of MTh. The results indicate that the hydrolytic mechanism is facilitated by an intramolecular hydrogen bond to the carboxylate of MTh. This interaction reduces the electron density on the carboxylate carbon and promotes hydration. A serine residue (S26) in BFDC is proposed to prevent internal return by trapping the nascent CO2 as a carbonate monoester. We hypothesized that an active site water could act as a surrogate nucleophile in BFDC mutants lacking S26. This would be analogous to the hydrolytic decarboxylation of MTh, resulting in the production of HCO3- upon carbon-carbon bond cleavage. Using a coupled assay with carbonic anhydrase, a number of BFDC variants were determined to release CO2. This indicates that either CO2 is produced in these decarboxylation reactions or that bicarbonate is converted to CO2 prior to its release from the active site. Advisors/Committee Members: Kluger, Ronald H, Chemistry.

Subjects/Keywords: 0485

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Howe, G. W. (2016). Accelerating Decarboxylation Reactions through the Formation of Bicarbonate. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/76468

Chicago Manual of Style (16^th Edition):

Howe, Graeme William. “Accelerating Decarboxylation Reactions through the Formation of Bicarbonate.” 2016. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/76468.

MLA Handbook (7^th Edition):

Howe, Graeme William. “Accelerating Decarboxylation Reactions through the Formation of Bicarbonate.” 2016. Web. 22 Jan 2021.

Vancouver:

Howe GW. Accelerating Decarboxylation Reactions through the Formation of Bicarbonate. [Internet] [Doctoral dissertation]. University of Toronto; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/76468.

Council of Science Editors:

Howe GW. Accelerating Decarboxylation Reactions through the Formation of Bicarbonate. [Doctoral Dissertation]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/76468

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