subject:( technology)

1. Morandini, Yvan. Évaluation de nouvelles varicaps en technologie silicium : Investigations of new varactors in silicon technologies.

Degree: Docteur es, Microondes et microtechnologies, 2008, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2008LIL10059

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Les spécifications des standards de transmission de données, par exemple la télévision numérique terrestre (VHF, UHF, L1, L2, S-band), la téléphonie mobile (GSM, GPRS, EDGE,… (more)

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Les spécifications des standards de transmission de données, par exemple la télévision numérique terrestre (VHF, UHF, L1, L2, S-band), la téléphonie mobile (GSM, GPRS, EDGE, UMTS, ... ) ou l'augmentation du débit d'information sans fils (WIFI, WiMax, Bluetooth, WHDMI, ... ), nécessitent entre autres une réduction du seuil de détection et une densification des canaux. Plusieurs solutions permettent d'augmenter le débit d'information, soit l'augmentation de la quantité d'information transportée par la porteuse radio-fréquence, soit la multiplication des porteuses à l'intérieur d'une bande de fréquence. La qualité spectrale des signaux porteurs devient alors un point clé pour garantir l'intégrité de l'information. Au cœur de la génération ou de la détection des signaux, la varicap, capacité variable à commande électrique, est un des éléments prépondérants déterminant les performances de la chaîne de transmission. La thèse concerne l'étude de nouvelles varicaps en technologies CMOS sub-90nm et BiCMOS sub-250nm. Après avoir introduit le contexte général de l'étude, nous présentons un état de l'art des varicaps, puis nous définissons les facteurs de performances et les outils d'évaluation d'une technologie et d'une famille de varicaps afin de fournir les pistes d'amélioration à travers les caractéristiques électriques et géométriques. Le premier axe de nos travaux s'intéresse à l'évaluation de nouvelles structures de varicaps autour de la capacité intrinsèque et de l'aspect architecture!. Le deuxième axe se consacre à l'étude des techniques de mesures plus proches du contexte d'utilisation de la varicap dans un système. Pour conclure, nous décrivons la mise en place d'un véhicule de test type VCO en technologie CMOS 65nm afin de quantifier les facteurs de performances à l'échelle du circuit. A terme, ce travail fournit une bibliothèque de données techniques et d'architectures permettant de réduire le temps de développement des futures varicaps.

The specifications of the standard data transmission, such as digital terrestrial television (VHF, UHF, L1, L2, S-band), mobile (GSM, GPRS, EDGE, UMTS, ... ) or the growth of the flow of the wireless data (WiFi, WiMax, Bluetooth, WHDMI ... ), require a reduction in the threshold of detection and a densification of channels. Several solutions can increase the flow of data: the growth of the amount of information carried by the radio-frequency carrier or the multiplication of carriers within a band. The spectral quality of signaIs becomes a key to ensuring the information integrity. At the heart of the generation and detection signaIs, the varactor, variable capacitance in function of the supply voltage, is a crucial element determining the performance of the chain of transmission. The thesis deals with the study of new varactors in technology sub-90nm CMOS and sub-250nm BiCMOS technologies. After introducing the general context of the study, we present a state of the art of varactor, then we define the performance factors and assessment tools of technologies to provide the…

Advisors/Committee Members: Gaquière, Christophe (thesis director), Larchanché, Jean-François (thesis director).

Subjects/Keywords: Technologie BiCMOS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Morandini, Y. (2008). Évaluation de nouvelles varicaps en technologie silicium : Investigations of new varactors in silicon technologies. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2008LIL10059

Chicago Manual of Style (16^th Edition):

Morandini, Yvan. “Évaluation de nouvelles varicaps en technologie silicium : Investigations of new varactors in silicon technologies.” 2008. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed April 18, 2021. http://www.theses.fr/2008LIL10059.

MLA Handbook (7^th Edition):

Morandini, Yvan. “Évaluation de nouvelles varicaps en technologie silicium : Investigations of new varactors in silicon technologies.” 2008. Web. 18 Apr 2021.

Vancouver:

Morandini Y. Évaluation de nouvelles varicaps en technologie silicium : Investigations of new varactors in silicon technologies. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2008. [cited 2021 Apr 18]. Available from: http://www.theses.fr/2008LIL10059.

Council of Science Editors:

Morandini Y. Évaluation de nouvelles varicaps en technologie silicium : Investigations of new varactors in silicon technologies. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2008. Available from: http://www.theses.fr/2008LIL10059

Brno University of Technology

2. Palacký, Vladislav. Sestavení technologie pro součást "kabelová spojka" s etapou rapid prototyping: Solution production technology of part "cable connector" on a rapid prototyping.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/20945

► Thesis consists of the entirety of theoretical and computational knowledge processing for the designing and manufacturing of cable connector. This work includes two technically viable… (more)

Subjects/Keywords: Obrábění; technologie výroby; vstřikování plastů; aditivní technologie.; Machining; production technology; injection molding; additive technology.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Palacký, V. (2019). Sestavení technologie pro součást "kabelová spojka" s etapou rapid prototyping: Solution production technology of part "cable connector" on a rapid prototyping. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/20945

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Palacký, Vladislav. “Sestavení technologie pro součást "kabelová spojka" s etapou rapid prototyping: Solution production technology of part "cable connector" on a rapid prototyping.” 2019. Thesis, Brno University of Technology. Accessed April 18, 2021. http://hdl.handle.net/11012/20945.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Palacký, Vladislav. “Sestavení technologie pro součást "kabelová spojka" s etapou rapid prototyping: Solution production technology of part "cable connector" on a rapid prototyping.” 2019. Web. 18 Apr 2021.

Vancouver:

Palacký V. Sestavení technologie pro součást "kabelová spojka" s etapou rapid prototyping: Solution production technology of part "cable connector" on a rapid prototyping. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11012/20945.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Palacký V. Sestavení technologie pro součást "kabelová spojka" s etapou rapid prototyping: Solution production technology of part "cable connector" on a rapid prototyping. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/20945

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Zerkani, Baghdadi. Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph.

Degree: 2012, Université M'Hamed Bougara Boumerdès

URL: http://dlibrary.univ-boumerdes.dz:8080123456789/1531

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90 p. : ill. ; 30 cm

L'utilisation de nouvelles technologies dans l'industrie améliore certes la productivité mais induit une complexité du système industriel, cette… (more)

Subjects/Keywords: Tolérance (technologie); Pipelines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zerkani, B. (2012). Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph. (Thesis). Université M'Hamed Bougara Boumerdès. Retrieved from http://dlibrary.univ-boumerdes.dz:8080123456789/1531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zerkani, Baghdadi. “Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph.” 2012. Thesis, Université M'Hamed Bougara Boumerdès. Accessed April 18, 2021. http://dlibrary.univ-boumerdes.dz:8080123456789/1531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zerkani, Baghdadi. “Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph.” 2012. Web. 18 Apr 2021.

Vancouver:

Zerkani B. Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph. [Internet] [Thesis]. Université M'Hamed Bougara Boumerdès; 2012. [cited 2021 Apr 18]. Available from: http://dlibrary.univ-boumerdes.dz:8080123456789/1531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zerkani B. Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph. [Thesis]. Université M'Hamed Bougara Boumerdès; 2012. Available from: http://dlibrary.univ-boumerdes.dz:8080123456789/1531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Zerkani, Baghdadi. Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph.

Degree: 2012, Université M'Hamed Bougara Boumerdès

URL: http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/1123

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90 p. ; ill. ; 30 cm

L'utilisation de nouvelles technologies dans l'industrie améliore certes la productivité mais induit une complexité du système industriel, cette… (more)

Subjects/Keywords: Tolérance (technologie); Pipelines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zerkani, B. (2012). Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph. (Thesis). Université M'Hamed Bougara Boumerdès. Retrieved from http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/1123

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zerkani, Baghdadi. “Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph.” 2012. Thesis, Université M'Hamed Bougara Boumerdès. Accessed April 18, 2021. http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/1123.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zerkani, Baghdadi. “Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph.” 2012. Web. 18 Apr 2021.

Vancouver:

Zerkani B. Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph. [Internet] [Thesis]. Université M'Hamed Bougara Boumerdès; 2012. [cited 2021 Apr 18]. Available from: http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/1123.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zerkani B. Diagnostic et commande tolérante aux défauts des systèmes complexes par l'approche bond graph. [Thesis]. Université M'Hamed Bougara Boumerdès; 2012. Available from: http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/1123

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Hérisson, David. Étude des comportements des premiers Néandertaliens du Nord de la France : les occupations saaliennes des gisements de Biache-Saint-Vaast et de Therdonne : Study of the first neanderthals behaviour of northern France saalian occupations of Biache-Saint-Vaast and Therdonne sites.

Degree: Docteur es, Préhistoire, 2012, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2012LIL10181

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Cette thèse est le fruit de la réunion de notre attrait pour deux domaines de recherche sur l'homme que sont la préhistoire et les sciences… (more)

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Cette thèse est le fruit de la réunion de notre attrait pour deux domaines de recherche sur l'homme que sont la préhistoire et les sciences cognitives. Elle s'inscrit dans le cadre de la théorie synthétique de l'évolution et cherche à contribuer à notre connaissance des processus évolutifs, et plus modestement à ceux guidant l'évolution des premiers Néandertaliens présents en France septentrionale. Le terme comportement est omniprésent à l'heure actuelle dans les articles français de préhistoire. Si le recours au terme est récurrent, son emploi est souvent abusif ou approximatif et révèle l'indéniable oubli de son sens et des concepts qu'il renferme. Le choix d'étudier le comportement des hommes préhistoriques a nécessité de retourner aux origines du mot et des concepts sous-entendus qui ont mené à sa définition actuelle. Cet enrichissant cheminement débouche sur la proposition de démarche qui a été menée dans ce travail : intégrer et adapter les méthodes et démarches développées dans les sciences du comportement à celle de préhistorien afin d'apporter un autre point de vue et un autre niveau d'interprétation aux données analysées. Cette démarche impose de sélectionner judicieusement la matière première que sont les gisements préhistoriques dans le but de reconstituer le comportement de ses occupants. Notre étude s'est focalisée sur un peu plus de 150 000 ans d'histoire retraçant l'aventure des premiers Néandertaliens du Nord de la France. Pour se faire, deux gisements représentant huit occupations néandertaliennes ont été sélectionnés et étudiés pour la qualité et la diversité des informations qu'ils recelaient en terme comportemental : Biache-Saint Vaast et Therdonne.

This thesis is the result of the meeting of our appeal for two research domains on Human that are Prehistory and cognitive sciences. It joins within the framework of the synthetic theory of Evolution and tries to contribute to our knowledge of evolutionary processes, and more modestly to those guiding the evolution of the first Neanderthals settling northern France. The term «comportement» (behaviour) is now omnipresent in French papers of Prehistory. If the recourse to the term is recurring, its employment is often excessive or approximate and reveals the undeniable forgetting of its underlying meaning and concepts it contains. The choice to study Neanderthal behaviour required to return to the origins of the word and the understood concepts which led to its current definition. This enriching progression results at the suggestion of approach which was led in this work: integrate and adapt the methods and the approaches developed in behaviour sciences in our approach of prehistorian to bring another point of view and another level of interpretation to analyze datas. This approach imposes to select sensibly the raw material that are the prehistoric occupations in order to reconstitute occupants behaviour. Our study focused on a little more than 150 000 years of history redrawing the adventure of the first Neanderthals of northern France. To be made,…

Advisors/Committee Members: Tuffreau, Alain (thesis director).

Subjects/Keywords: Technologie lithique; 930.12

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hérisson, D. (2012). Étude des comportements des premiers Néandertaliens du Nord de la France : les occupations saaliennes des gisements de Biache-Saint-Vaast et de Therdonne : Study of the first neanderthals behaviour of northern France saalian occupations of Biache-Saint-Vaast and Therdonne sites. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2012LIL10181

Chicago Manual of Style (16^th Edition):

Hérisson, David. “Étude des comportements des premiers Néandertaliens du Nord de la France : les occupations saaliennes des gisements de Biache-Saint-Vaast et de Therdonne : Study of the first neanderthals behaviour of northern France saalian occupations of Biache-Saint-Vaast and Therdonne sites.” 2012. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed April 18, 2021. http://www.theses.fr/2012LIL10181.

MLA Handbook (7^th Edition):

Hérisson, David. “Étude des comportements des premiers Néandertaliens du Nord de la France : les occupations saaliennes des gisements de Biache-Saint-Vaast et de Therdonne : Study of the first neanderthals behaviour of northern France saalian occupations of Biache-Saint-Vaast and Therdonne sites.” 2012. Web. 18 Apr 2021.

Vancouver:

Hérisson D. Étude des comportements des premiers Néandertaliens du Nord de la France : les occupations saaliennes des gisements de Biache-Saint-Vaast et de Therdonne : Study of the first neanderthals behaviour of northern France saalian occupations of Biache-Saint-Vaast and Therdonne sites. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2012. [cited 2021 Apr 18]. Available from: http://www.theses.fr/2012LIL10181.

Council of Science Editors:

Hérisson D. Étude des comportements des premiers Néandertaliens du Nord de la France : les occupations saaliennes des gisements de Biache-Saint-Vaast et de Therdonne : Study of the first neanderthals behaviour of northern France saalian occupations of Biache-Saint-Vaast and Therdonne sites. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2012. Available from: http://www.theses.fr/2012LIL10181

6. PORTELA , Christian Albert da Silva. A influência dos Smartphones na relação ensino/aprendizagem em uma escola de ensino médio da zona rural da região metropolitana de São Luís/Ma.

Degree: 2019, Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM EDUCAÇÃO/CCSO; UFMA; Brasil; DEPARTAMENTO DE EDUCAÇÃO II/CCSO

URL: https://tedebc.ufma.br/jspui/handle/tede/tede/3131

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Made available in DSpace on 2021-01-13T12:33:50Z (GMT). No.… (more)

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Submitted by Sheila MONTEIRO ([email protected]) on 2021-01-13T12:33:50Z No. of bitstreams: 1 CHRISTIAN-PORTELA.pdf: 1390777 bytes, checksum: 29f436e7f65d77ffbe1c9fbdf4a2e14d (MD5)

Made available in DSpace on 2021-01-13T12:33:50Z (GMT). No. of bitstreams: 1 CHRISTIAN-PORTELA.pdf: 1390777 bytes, checksum: 29f436e7f65d77ffbe1c9fbdf4a2e14d (MD5) Previous issue date: 2019-02-12

The development of digital technologies has brought a significant set of changes to the teaching and learning process, from mobile communication and information devices to new methodologies and conceptual models of teaching. The purpose of this study was to analyze the influence of smart-phones in a rural school, their use in pedagogical activities, transformations in teaching-learning relationships, and the consequences on teaching-learning relations in the exchange of information and knowledge. The school was located in the municipality of Paço do Lumiar, an area in transition from rural to urban as it is absorbed by metropolitan region of São Luís / MA, Brazil. The qualitative/quantitative approach is used in field research in the perspective of “Dialectical Historical Materialism” and the instruments used were: observations recorded in field notes, questionnaires completed by seventy-one students, and interviews with four teachers. The results show that the use of the smart-phone in the classroom can constitute a transforming material element of the pedagogical praxis, and that the teachers who have started to introduce it into their classroom practices have been successful, despite what we classify as "functional deviation in the digital immersion" (DFID), a phenomenon widely observed by teachers which gives rise to concern on their part, as the device has a subjective rather than objective functionality, being multifunctional, or dysfunctional (as Baudrillard tells us about technological objects: gadgets). Another result observed was the need for greater attention from the educational authorities in Maranhão to the quality of the connectivity infrastructure offered by the school unit, which in this case is precarious, and we can infer that other rural school units more distant from large urban centers suffer from the same precariousness. This is incompatible with the educational and pedagogical needs of the 21st century, relegating the school community to a process of "digital exclusion", which in this case is promoted by the educational institution. We also note the need for a curriculum that is formative and teaching that is more adapted to the times of ubiquitous connectivity, as is the case of the “web curriculum”, a curricular proposal more appropriate to our times. References for this research include among others - for the question of technological objects and cyberculture: Pierre Lévy (1993/1995/1999) and Jean Baudrillard (1992/1995/2009); for the methodology of Dialectical Historical Materialism: Karl Marx (2008), Karel Kosik (2002), Frigotto (2000), Vazquez (2003); instruments: …

Advisors/Committee Members: LAUANDE, Maria de Fátima Ribeiro Franco, LAUANDE, Maria de Fátima Ribeiro Franco, PORTELA, Edinólia Lima, BOTTENTUIT JUNIOR, João Batista.

Subjects/Keywords: Educação; Tecnologia; Smartphone; Ensino-aprendizagem; Education; Technologie; Smartphone; Teaching-learning; Tecnologia Educacional

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

PORTELA , C. A. d. S. (2019). A influência dos Smartphones na relação ensino/aprendizagem em uma escola de ensino médio da zona rural da região metropolitana de São Luís/Ma. (Masters Thesis). Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM EDUCAÇÃO/CCSO; UFMA; Brasil; DEPARTAMENTO DE EDUCAÇÃO II/CCSO. Retrieved from https://tedebc.ufma.br/jspui/handle/tede/tede/3131

Chicago Manual of Style (16^th Edition):

PORTELA , Christian Albert da Silva. “A influência dos Smartphones na relação ensino/aprendizagem em uma escola de ensino médio da zona rural da região metropolitana de São Luís/Ma.” 2019. Masters Thesis, Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM EDUCAÇÃO/CCSO; UFMA; Brasil; DEPARTAMENTO DE EDUCAÇÃO II/CCSO. Accessed April 18, 2021. https://tedebc.ufma.br/jspui/handle/tede/tede/3131.

MLA Handbook (7^th Edition):

PORTELA , Christian Albert da Silva. “A influência dos Smartphones na relação ensino/aprendizagem em uma escola de ensino médio da zona rural da região metropolitana de São Luís/Ma.” 2019. Web. 18 Apr 2021.

Vancouver:

PORTELA CAdS. A influência dos Smartphones na relação ensino/aprendizagem em uma escola de ensino médio da zona rural da região metropolitana de São Luís/Ma. [Internet] [Masters thesis]. Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM EDUCAÇÃO/CCSO; UFMA; Brasil; DEPARTAMENTO DE EDUCAÇÃO II/CCSO; 2019. [cited 2021 Apr 18]. Available from: https://tedebc.ufma.br/jspui/handle/tede/tede/3131.

Council of Science Editors:

PORTELA CAdS. A influência dos Smartphones na relação ensino/aprendizagem em uma escola de ensino médio da zona rural da região metropolitana de São Luís/Ma. [Masters Thesis]. Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM EDUCAÇÃO/CCSO; UFMA; Brasil; DEPARTAMENTO DE EDUCAÇÃO II/CCSO; 2019. Available from: https://tedebc.ufma.br/jspui/handle/tede/tede/3131

7. Oumohand, Ouerdia. Les structures intermédiaires entre les laboratoires de recherche publique et lesentreprises : intermediary structures between university and industry.

Degree: Docteur es, Sciences de Gestion, 2020, Université Paris-Est

URL: http://www.theses.fr/2020PESC1019

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Il est largement admis que l’intensité des liens entre la recherche publique et le monde socioéconomique est positivement corrélée avec la croissance et la compétitivité.… (more)

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Il est largement admis que l’intensité des liens entre la recherche publique et le monde socioéconomique est positivement corrélée avec la croissance et la compétitivité. Cependant, plusieurs facteurs freinent cette collaboration, ces freins peuvent être levés par la création des intermédiaires. C’est pourquoi, plusieurs initiatives ont été menées par les décideurs politiques afin de renforcer le couplage entre l’université et l’industrie, notamment par le vote du Bayh-Dole Act aux Etats-Unis en 1980 et la loi sur l’innovation de 1999 en France. Toutefois, ces lois et mesures ont créé plusieurs structures d’intermédiation qui effectuent des fonctions similaires ou différentes et coexistant à différentes échelles (nationale, régionale ou locale). Ces structures peuvent être internes ou externes aux universités à titre d’exemples les services d’activités industrielles et commerciales (SAIC), les SATT, les incubateurs, les CRITT, les pôles de compétitivité, les instituts Carnot, les SRC, les SCR, les CTI … etc. Cette multiplicité des structures a complexifié le paysage de la valorisation en France. Ce constat a été posé par plusieurs rapports gouvernementaux et études. Les discussions récurrentes de ces rapports tournent autour des éventuelles concurrences et redondances des activités de ces structures d’intermédiation. Dans cette thèse, nous avons souhaité déplacer la focale, et nous nous sommes intéressés plutôt à l’utilité de ces structures vis-à-vis de leurs utilisateurs, ainsi que les modalités de mise en œuvre de leurs activités. Cette problématique nous a poussé à comprendre les formes d'intermédiation entre la recherche publique et le monde industriel, et proposer un modèle conceptuel de ces interactions. L’apport de notre thèse vise, par conséquent, à éclairer les débats qui deviennent de plus en plus grandissant dans les politiques publiques sur ce thème

It is broadly recognized that the intensity of the interactions between university and industry is positively correlated with growth and competitiveness. However, several factors hamper this collaboration. Thus, various initiatives have been taken by policy makers to strengthen the linkages between academia and industry. The most important ones have probably been for the United States the vote of the Bayh-Dole Act in 1980 and, for France, the law on innovation voted in 1999. These laws and measures have created an important number of intermediation structures that perform similar or different functions, and coexist at different scales (national, regional or local). These structures can be internal or external to the universities, for instance in France, the university services of industrial and commercial activities (SAIC), the societies for technology transfer (SATT), incubators, the technology transfer centers (CRITT), the ‘pôles de compétitivité’ or the Carnot institutes. According to many reports, this multiplicity of structures has complexified the France innovation ecosystem, causing competition between intermediaries and redundancy in their…

Advisors/Committee Members: Larédo, Philippe (thesis director).

Subjects/Keywords: Intermédiaires; Valorisation de la recherche; Transfert de technologie; Intermediaries; Technology transfer; Technologie transfer office

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oumohand, O. (2020). Les structures intermédiaires entre les laboratoires de recherche publique et lesentreprises : intermediary structures between university and industry. (Doctoral Dissertation). Université Paris-Est. Retrieved from http://www.theses.fr/2020PESC1019

Chicago Manual of Style (16^th Edition):

Oumohand, Ouerdia. “Les structures intermédiaires entre les laboratoires de recherche publique et lesentreprises : intermediary structures between university and industry.” 2020. Doctoral Dissertation, Université Paris-Est. Accessed April 18, 2021. http://www.theses.fr/2020PESC1019.

MLA Handbook (7^th Edition):

Oumohand, Ouerdia. “Les structures intermédiaires entre les laboratoires de recherche publique et lesentreprises : intermediary structures between university and industry.” 2020. Web. 18 Apr 2021.

Vancouver:

Oumohand O. Les structures intermédiaires entre les laboratoires de recherche publique et lesentreprises : intermediary structures between university and industry. [Internet] [Doctoral dissertation]. Université Paris-Est; 2020. [cited 2021 Apr 18]. Available from: http://www.theses.fr/2020PESC1019.

Council of Science Editors:

Oumohand O. Les structures intermédiaires entre les laboratoires de recherche publique et lesentreprises : intermediary structures between university and industry. [Doctoral Dissertation]. Université Paris-Est; 2020. Available from: http://www.theses.fr/2020PESC1019

Universidade do Porto

8. Oliveira, Rita Cristina Sanches de. Desenvolvimento, Formulação e Avaliação de Sistemas de Libertação Transdérmica Incorporando Sistemas Ternários de Complexação (Fármaco/Ciclodextrina/Polímero).

Degree: 2011, Universidade do Porto

URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/10805

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Doutoramento em Tecnologia Farmacêutica

PhD Degree - Pharmaceutical Technology

As ciclodextrinas são oligossacarídeos cíclicos com várias aplicações farmacêuticas. Apresentam uma cavidade central hidrofóbica, cuja estrutura… (more)

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Doutoramento em Tecnologia Farmacêutica

PhD Degree - Pharmaceutical Technology

As ciclodextrinas são oligossacarídeos cíclicos com várias aplicações farmacêuticas. Apresentam uma cavidade central hidrofóbica, cuja estrutura permite formar complexos de inclusão estáveis com diversos fármacos. Neste trabalho, pretende-se associar as propriedades de complexação das ciclodextrinas à sua capacidade de promover a permeação de fármacos através da pele, utilizando como sistema transportador um adesivo transdérmico do tipo matricial em monocamada. O Naproxeno, sendo um fármaco pouco solúvel, constitui um bom modelo para a complexação com as ciclodextrinas. Foram desenvolvidos complexos binários de Naproxeno com as ciclodextrinas hidrossolúveis ß-ciclodextrina, hidroxipropil-ß- ciclodextrina e metil-ß-ciclodextrina, e complexos ternários utilizando as mesmas ciclodextrinas associadas com os polímeros hidrossolúveis polivinilpirrolidona e hidroxipropilmetilcelulose. Utilizando várias técnicas de análise, como estudos de solubilidade, a espectroscopia de ressonância magnética nuclear, a calorimetria de varrimento diferencial, a espectroscopia de infravermelho com transformadas de Fourier e a difracção de raios X, foi possível detectar e caracterizar os complexos de inclusão preparados, tanto em solução como no estado sólido. A avaliação das propriedades de dissolução do Naproxeno permitiu seleccionar os complexos com a ß-ciclodextrina e com a metil-ß-ciclodextrina, associados ou não com a hidroxipropilmetilcelulose, e preparados pelo método da coevaporação, como os melhores candidatos à preparação de formulações de libertação controlada para administração transdérmica. Os estudos de permeação do Naproxeno através da pele de porco, realizados com os adesivos transdérmicos desenvolvidos, demonstraram que o processo de permeação é influenciado pela matriz polimérica e que a sua cinética é linear com a raiz quadrada do tempo. Este trabalho permitiu obter um adesivo transdérmico contendo Naproxeno complexado com metil-ß-ciclodextrina-hidroxipropilmetilcelulose, promovendo a permeação do fármaco através da pele.

Cyclodextrins are ciclic oligosaccharides with several pharmaceutical applications. They present a central hidrophobic cavity, whose structure allows the formation of stable inclusion complexes with many drugs. The aim of this work is to combine the cyclodextrin complex formation properties with their capacity of enhancing the permeation of drugs across the skin, using as a delivery system a transdermic matricial monolayer patch. Naproxen, a poorly soluble drug, is a good model for preparing cyclodextrin complexes. Binary complexes of Naproxen and hydrophilic ß-cyclodextrin, hidroxipropil-ß-cyclodextrin and methyl-ß-cyclodextrin were prepared. Ternary complexes combining the same cyclodextrins, Naproxen and the water soluble polymers hydroxypropylmethylcellulose and polyvinylpyrrolidone were also prepared. The application of several techniques such as solubility assays, nuclear magnetic resonance spectroscopy,…

Subjects/Keywords: Tecnologia Farmacêutica; Pharmaceutical Technology; Porto

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oliveira, R. C. S. d. (2011). Desenvolvimento, Formulação e Avaliação de Sistemas de Libertação Transdérmica Incorporando Sistemas Ternários de Complexação (Fármaco/Ciclodextrina/Polímero). (Thesis). Universidade do Porto. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/10805

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Oliveira, Rita Cristina Sanches de. “Desenvolvimento, Formulação e Avaliação de Sistemas de Libertação Transdérmica Incorporando Sistemas Ternários de Complexação (Fármaco/Ciclodextrina/Polímero).” 2011. Thesis, Universidade do Porto. Accessed April 18, 2021. http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/10805.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Oliveira, Rita Cristina Sanches de. “Desenvolvimento, Formulação e Avaliação de Sistemas de Libertação Transdérmica Incorporando Sistemas Ternários de Complexação (Fármaco/Ciclodextrina/Polímero).” 2011. Web. 18 Apr 2021.

Vancouver:

Oliveira RCSd. Desenvolvimento, Formulação e Avaliação de Sistemas de Libertação Transdérmica Incorporando Sistemas Ternários de Complexação (Fármaco/Ciclodextrina/Polímero). [Internet] [Thesis]. Universidade do Porto; 2011. [cited 2021 Apr 18]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/10805.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oliveira RCSd. Desenvolvimento, Formulação e Avaliação de Sistemas de Libertação Transdérmica Incorporando Sistemas Ternários de Complexação (Fármaco/Ciclodextrina/Polímero). [Thesis]. Universidade do Porto; 2011. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/10805

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Vasconcelos, Allan Diniz Ferreira. Um percurso entre práticas artísticas na cidade de Fortaleza: diálogos entre arte, comunicação, cidade e tecnologia.

Degree: 2016, Brazil

URL: http://www.repositorio.ufc.br/handle/riufc/26619

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VASCONCELOS, Allan Diniz Ferreira. Um percurso entre práticas artísticas na cidade de Fortaleza: diálogos entre arte, comunicação, cidade e tecnologia. 2016. 157f. – Dissertação (Mestrado)… (more)

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VASCONCELOS, Allan Diniz Ferreira. Um percurso entre práticas artísticas na cidade de Fortaleza: diálogos entre arte, comunicação, cidade e tecnologia. 2016. 157f. – Dissertação (Mestrado) – Universidade Federal do Ceará, Programa de Pós-graduação em Comunicação Social, Fortaleza (CE), 2016.

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Approved for entry into archive by Márcia Araújo ([email protected]) on 2017-10-13T10:57:37Z (GMT) No. of bitstreams: 1 2016_dis_adfvasconcelos.pdf: 13162185 bytes, checksum: 948394a46e1b36e64dbdda51561d985a (MD5)

Made available in DSpace on 2017-10-13T10:57:37Z (GMT). No. of bitstreams: 1 2016_dis_adfvasconcelos.pdf: 13162185 bytes, checksum: 948394a46e1b36e64dbdda51561d985a (MD5) Previous issue date: 2016

Apropriando-se da ideia de cidade como campo ampliado da comunicação e da arte, esta pesquisa pratico-teorica objetiva investigar experimentações artísticas que envolvem o uso de novas tecnologias, dispositivos moveis e mídias locativas, estabelecendo uma relação direta com a cidade de Fortaleza. Partindo de um percurso atravessado pela observação, participação, construção de relações e intercambio de experiencias, foi feita uma analise de trabalhos de três artistas que atuam na capital cearense: David da Paz, Cecilia Andrade e Andre Lopes. Devido a aproximação e a diversidade dessas propostas artísticas, questões como agenciamento de praticas colaborativas; dialogos entre videoperformances geolocalizadas e poeticas nomades; apagamentos e disputas de imaginarios urbanos, nocoes de publico, privado e redes sociais virtuais no espaco citadino e vizinhanca, proximidade e entorno ligadas aos usos de tecnologias ordinarias contribuiram para a construcao de um pensamento que apresenta novas dinâmicas na configuracao de cibercidades contemporaneas. Embasado por nocoes de site-specific e pelo olhar de De Certeau sobre formas de inventar e praticar o cotidiano, sao construidos aqui desdobramentos criticos a partir de um espaco social conectado por formas criativas de reiventar uma cidade tensionada por fluxos informativos e intensos processos de transformacoes politico-economico-sociais.

Advisors/Committee Members: Oliveira Júnior, Antônio Wellington de.

Subjects/Keywords: Cidade; Tecnologia; Comunicação; Technology; Communication

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vasconcelos, A. D. F. (2016). Um percurso entre práticas artísticas na cidade de Fortaleza: diálogos entre arte, comunicação, cidade e tecnologia. (Masters Thesis). Brazil. Retrieved from http://www.repositorio.ufc.br/handle/riufc/26619

Chicago Manual of Style (16^th Edition):

Vasconcelos, Allan Diniz Ferreira. “Um percurso entre práticas artísticas na cidade de Fortaleza: diálogos entre arte, comunicação, cidade e tecnologia.” 2016. Masters Thesis, Brazil. Accessed April 18, 2021. http://www.repositorio.ufc.br/handle/riufc/26619.

MLA Handbook (7^th Edition):

Vasconcelos, Allan Diniz Ferreira. “Um percurso entre práticas artísticas na cidade de Fortaleza: diálogos entre arte, comunicação, cidade e tecnologia.” 2016. Web. 18 Apr 2021.

Vancouver:

Vasconcelos ADF. Um percurso entre práticas artísticas na cidade de Fortaleza: diálogos entre arte, comunicação, cidade e tecnologia. [Internet] [Masters thesis]. Brazil; 2016. [cited 2021 Apr 18]. Available from: http://www.repositorio.ufc.br/handle/riufc/26619.

Council of Science Editors:

Vasconcelos ADF. Um percurso entre práticas artísticas na cidade de Fortaleza: diálogos entre arte, comunicação, cidade e tecnologia. [Masters Thesis]. Brazil; 2016. Available from: http://www.repositorio.ufc.br/handle/riufc/26619

Pontifical Catholic University of Rio de Janeiro

10. INDIA MARA MARTINS. [en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN.

Degree: 2009, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765

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[pt] O objetivo desta tese é refletir sobre o documentário animado. Um produto audiovisual que mistura documentário e animação e está redefinindo o papel do… (more)

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[pt] O objetivo desta tese é refletir sobre o documentário animado. Um produto audiovisual que mistura documentário e animação e está redefinindo o papel do design na produção das novas mídias. Mostramos também que o documentário animado reacende uma série de debates e reflexões relativas à teoria do documentário e da animação em relação às concepções de realismo. A nossa principal premissa é que o documentário sempre se apropriou da tecnologia de forma a favorecer a experimentação e, o documentário animado, em 3D, é a sua forma de se apropriar das tecnologias digitais. Para comprovar esta hipótese mostramos como a experimentação da tecnologia se deu no documentário em diferentes épocas, mais precisamente nos períodos do primeiro cinema, das vanguardas e da escola britânica – de 1900 a 1930, os anos de 1960, e os anos de 1990 (novas mídias). O que nos interessa é investigar esta relação entre os meios de produção utilizados na realização do documentário – quer tenham esta denominação ou não – e os modos de representação e estilos resultantes da tecnologia de cada época, que pretendemos delinear brevemente. O Design está presente nos dois aspectos: nos meios de produção, por sua tradição ligada ao desenvolvimento de tecnologias e instrumentos para viabilizar a produção, e nos modos de representação, porque as referências estéticas da animação são oriundas das artes gráficas (quadrinhos, ilustrações, etc). Isto também explica, em parte, a ausência da animação na teoria do cinema, aspecto que questionamos, mostrando como a animação está contemplada na teoria Deleuziana. Para concluir, fazemos um estudo de caso de um documentário animado emblemático, por sua abordagem da tecnologia 3D. Ryan (2004), de Chris Landreth, resume o potencial do documentário animado enquanto experimentação da tecnologia, intensidade narrativa e estética não figurativa, em singular referência ao pintor Francis Bacon.

[en] The objective of this thesis is to reflect on the animated documentary. An audiovisual product that mixes both documentary and animation and is redefining the role of the design in the production of new media. We also show that the animated documentary rekindled a series of debates and reflections related to documentary s theory and realism concepts in animation. Our main premise is that the documentary has always appropriated of technology in order to allow experimentation, and the animated documentary, in 3D, is the way to appropriate itself of digital technologies. To prove this hypothesis, we show how the trial of the technology occurred in documentary s history at different times, more precisely during the periods of the early cinema, the vanguards and the British School – from 1900 to 1930, the 1960 s and the 1990 s (new media). What concern us is to investigate this relationship between the means of production used in the making of documentary movies – having this denomination or not – and ways of representation and styles resulting from the technology of each period, which we intend to outline briefly. The Design is…

Advisors/Committee Members: LUIZ ANTONIO LUZIO COELHO.

Subjects/Keywords: [pt] TECNOLOGIA; [en] TECHNOLOGY; [fr] TECHNOLOGIE; [pt] DESIGN; [en] DESIGN; [fr] DESIGN; [pt] EXPERIMENTACAO; [en] EXPERIMENTATION; [fr] EXPERIMENTATION

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

MARTINS, I. M. (2009). [en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

MARTINS, INDIA MARA. “[en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN.” 2009. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed April 18, 2021. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

MARTINS, INDIA MARA. “[en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN.” 2009. Web. 18 Apr 2021.

Vancouver:

MARTINS IM. [en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2009. [cited 2021 Apr 18]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

MARTINS IM. [en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2009. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université du Québec à Montréal

11. Motaghi, Hamed. Creativity and technology in the context of creative industries.

Degree: 2015, Université du Québec à Montréal

URL: http://archipel.uqam.ca/8097/1/D2905.pdf

► L'objectif de notre thèse est d'examiner la place qu'occupe la créativité dans les technologies de l'information (TI). Nous présentons dans un premier lieu une discussion… (more)

▼ L'objectif de notre thèse est d'examiner la place qu'occupe la créativité dans les technologies de l'information (TI). Nous présentons dans un premier lieu une discussion des principaux travaux qui ont traité de la créativité dans les systèmes d'information (SI). Ensuite, nous discutons de la relation entre la créativité et la technologie. Cette thèse contient trois articles, et nous présentons ici le contenu de ces articles. Dans le premier article, nous avons effectué une revue de la littérature et nous avons examiné la place de la créativité dans les systèmes d'information et positionné cette recherche à partir de la classification d'Orlikowski et Scott (2008) de la variance, des processus et de la relationalité. Nous avons situé la littérature sur la créativité dans la recherche SI dans une logique de variance et nous avons proposé d'élargir la recherche en étudiant cette relation dans une logique de processus sociaux. Dans le second article, nous nous sommes concentrés sur l'impact des technologies sur la créativité et nous avons mené une étude ethnographique sur un festival à Québec. La contribution de cette article consiste à voir cet impact comme transmissif, interactif et imaginatif. Dans le troisième article, nous nous sommes concentrés sur l'impact de la créativité sur l'utilisation de la technologie et nous avons mené une recherche qualitative dans le secteur de la radio à Montréal. La contribution de cet article est de montrer l'importance de la créativité dans l'usage des systèmes d'information. L'objectif général de cette thèse est d'étendre la connaissance scientifique et pratique en ce qui concerne les SI et la relation entre la créativité et la technologie à partir de la logique du processus social. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : technologies, créativité, processus, acteurs, industries créatives, usage de technologie.

Subjects/Keywords: Créativité; Technologie; Créativité en technologie; Technologie de l'information; Systèmes d'information; Industries culturelles

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Motaghi, H. (2015). Creativity and technology in the context of creative industries. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/8097/1/D2905.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Motaghi, Hamed. “Creativity and technology in the context of creative industries.” 2015. Thesis, Université du Québec à Montréal. Accessed April 18, 2021. http://archipel.uqam.ca/8097/1/D2905.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Motaghi, Hamed. “Creativity and technology in the context of creative industries.” 2015. Web. 18 Apr 2021.

Vancouver:

Motaghi H. Creativity and technology in the context of creative industries. [Internet] [Thesis]. Université du Québec à Montréal; 2015. [cited 2021 Apr 18]. Available from: http://archipel.uqam.ca/8097/1/D2905.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Motaghi H. Creativity and technology in the context of creative industries. [Thesis]. Université du Québec à Montréal; 2015. Available from: http://archipel.uqam.ca/8097/1/D2905.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

12. Mazůrek, Tomáš. Technologie vytavitelného modelu v současnosti: Present state of investment casting technology.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/12382

► The bachelor’s thesis elaborated within the scope of full-time study of specialization B-STI Mechanical Engineering is dealing with procedures and methods of production castings using… (more)

Subjects/Keywords: Technologie odlévání; technologie vytavitelného modelu; přesné lití; kontrola odlitku; Casting technology; lost pattern technology; investment casting; casting inspection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mazůrek, T. (2019). Technologie vytavitelného modelu v současnosti: Present state of investment casting technology. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/12382

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mazůrek, Tomáš. “Technologie vytavitelného modelu v současnosti: Present state of investment casting technology.” 2019. Thesis, Brno University of Technology. Accessed April 18, 2021. http://hdl.handle.net/11012/12382.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mazůrek, Tomáš. “Technologie vytavitelného modelu v současnosti: Present state of investment casting technology.” 2019. Web. 18 Apr 2021.

Vancouver:

Mazůrek T. Technologie vytavitelného modelu v současnosti: Present state of investment casting technology. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11012/12382.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mazůrek T. Technologie vytavitelného modelu v současnosti: Present state of investment casting technology. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/12382

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

13. Černík, Pavel. Multimediální učebnice mikroelektronických technologií: The multimedia textbook of microelectronic technologies.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/12801

► In this bachelor's thesis, there is summary of technological process used in the manufacture of microelectronic circuits. For easier understanding of the processes, there are… (more)

Subjects/Keywords: PHP; MySQL; HTML; mikroelektronika; tenkovrstvé technologie; tlustovrstvé technologie; PHP; MySQL; HTML; microelectronics; thin-film technology; thick-film technology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Černík, P. (2019). Multimediální učebnice mikroelektronických technologií: The multimedia textbook of microelectronic technologies. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/12801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Černík, Pavel. “Multimediální učebnice mikroelektronických technologií: The multimedia textbook of microelectronic technologies.” 2019. Thesis, Brno University of Technology. Accessed April 18, 2021. http://hdl.handle.net/11012/12801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Černík, Pavel. “Multimediální učebnice mikroelektronických technologií: The multimedia textbook of microelectronic technologies.” 2019. Web. 18 Apr 2021.

Vancouver:

Černík P. Multimediální učebnice mikroelektronických technologií: The multimedia textbook of microelectronic technologies. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11012/12801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Černík P. Multimediální učebnice mikroelektronických technologií: The multimedia textbook of microelectronic technologies. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/12801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

14. Novotný, Michal. Technologie CNC výroby součásti z hliníkové slitiny: Technology of CNC production of aluminium alloy part.

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/32888

► The diploma thesis Technology of CNC production of aluminium alloy part is based on the particular specification of the company FP cz s.r.o. The core… (more)

Subjects/Keywords: hliníková slitina; CNC technologie; obrobitelnost; soustružení; technologie výroby; aluminium alloy; CNC technology; machinability; turning; production technology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Novotný, M. (2018). Technologie CNC výroby součásti z hliníkové slitiny: Technology of CNC production of aluminium alloy part. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/32888

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Novotný, Michal. “Technologie CNC výroby součásti z hliníkové slitiny: Technology of CNC production of aluminium alloy part.” 2018. Thesis, Brno University of Technology. Accessed April 18, 2021. http://hdl.handle.net/11012/32888.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Novotný, Michal. “Technologie CNC výroby součásti z hliníkové slitiny: Technology of CNC production of aluminium alloy part.” 2018. Web. 18 Apr 2021.

Vancouver:

Novotný M. Technologie CNC výroby součásti z hliníkové slitiny: Technology of CNC production of aluminium alloy part. [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11012/32888.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Novotný M. Technologie CNC výroby součásti z hliníkové slitiny: Technology of CNC production of aluminium alloy part. [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/32888

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

15. Hordějčuk, Jakub. Třískové a netřískové obrábění: Cutting and non-cutting operations.

Degree: 2014, Brno University of Technology

URL: http://hdl.handle.net/11012/7537

► Creating of any part may be by many ways, the choice of a particular method depends on many factors. The point of my bachelor's thesis… (more)

Subjects/Keywords: třískové obrábění; netřískové obrábění; konvenční technologie; nekonvenční technologie.; cutting operations; non-cutting operations; conventional technology; unconventional technology.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hordějčuk, J. (2014). Třískové a netřískové obrábění: Cutting and non-cutting operations. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/7537

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hordějčuk, Jakub. “Třískové a netřískové obrábění: Cutting and non-cutting operations.” 2014. Thesis, Brno University of Technology. Accessed April 18, 2021. http://hdl.handle.net/11012/7537.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hordějčuk, Jakub. “Třískové a netřískové obrábění: Cutting and non-cutting operations.” 2014. Web. 18 Apr 2021.

Vancouver:

Hordějčuk J. Třískové a netřískové obrábění: Cutting and non-cutting operations. [Internet] [Thesis]. Brno University of Technology; 2014. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11012/7537.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hordějčuk J. Třískové a netřískové obrábění: Cutting and non-cutting operations. [Thesis]. Brno University of Technology; 2014. Available from: http://hdl.handle.net/11012/7537

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

16. Kalenda, Jan. Elektroerozívní obrábění při výrobě tvarových dutin: The electrical discharge machining in production of shaped moulds.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/13412

► In this diploma thesis is theoretically written about the production of shaped cavities using electroerosive sinking. The possibilities of usage and the production of electrodes… (more)

Subjects/Keywords: elektroerozívní obrábění; nekonvenční technologie; materiály nástrojových elektrod; EDM technologie.; electro machining; EDM technology; unconvertional technology; elekctrosive sinking tools.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kalenda, J. (2019). Elektroerozívní obrábění při výrobě tvarových dutin: The electrical discharge machining in production of shaped moulds. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/13412

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kalenda, Jan. “Elektroerozívní obrábění při výrobě tvarových dutin: The electrical discharge machining in production of shaped moulds.” 2019. Thesis, Brno University of Technology. Accessed April 18, 2021. http://hdl.handle.net/11012/13412.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kalenda, Jan. “Elektroerozívní obrábění při výrobě tvarových dutin: The electrical discharge machining in production of shaped moulds.” 2019. Web. 18 Apr 2021.

Vancouver:

Kalenda J. Elektroerozívní obrábění při výrobě tvarových dutin: The electrical discharge machining in production of shaped moulds. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11012/13412.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kalenda J. Elektroerozívní obrábění při výrobě tvarových dutin: The electrical discharge machining in production of shaped moulds. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/13412

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Catholique de Louvain

17. Noyon, Christian. Les interactions écrites en ligne en classe de français langue étrangère : élaboration d’un dispositif, analyse des discours produits et analyse des représentations.

Degree: 2013, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/133397

►

Les interactions en classe de langue sont essentiellement orales. Cependant, l’émergence des technologies de l’information et de la communication ouvre la voie à de nouvelles… (more)

▼

Les interactions en classe de langue sont essentiellement orales. Cependant, l’émergence des technologies de l’information et de la communication ouvre la voie à de nouvelles formes de communications écrites. Les outils d’échanges écrits synchrones (le chat) comme asynchrones (les forums de discussion) permettent de mobiliser au sein d’une même tâche les compétences de scripteur et de lecteur des apprenants et font naitre la notion d’interaction écrite (ou d’interaction en ligne), une notion qui porte en elle la forte connotation sociale du Web 2.0. Pour nous, l’interaction « relève du domaine des relations humaines. Il y a interaction lorsque des hommes interagissent – par le biais des ordinateurs par exemple » (Ollivier et Puren. : 2011, 28). Par interaction écrite nous entendons toute activité d’interaction fondée sur l’utilisation de la langue écrite. Nous nous intéressons exclusivement aux interactions écrites sur les forums de discussions en classe de langue. Notre premier objectif de recherche est la mise en œuvre d’un dispositif dont les tâches ne s’accomplissent qu’au travers des interactions écrites sur les forums de discussion. Nous insisterons sur les paramètres qui conditionnent l’élaboration du dispositif et des tâches. Notre deuxième objectif de recherche est celui de l’analyse des discours produits sur les plateformes de discussion et de l’intérêt de ces discours dans une perspective didactique. Le troisième objectif de recherche est l’analyse des représentations des apprenants pour qui les tâches demandées et les discours produits constituent une nouvelle expérience d’apprentissage. Des résultats de cette dernière analyse, nous espérons pouvoir infirmer ou confirmer le choix des paramètres du dispositif. Nos hypothèses de travail sont les suivantes. Selon la première hypothèse, dans certaines conditions de production, il est légitime de dessiner des tâches d’apprentissage exclusivement basées sur des interactions écrites sur les forums de discussion. Selon notre deuxième hypothèse, les interactions écrites sur les forums de discussion amènent des productions langagières diversifiées et formatives pour un apprentissage du français langue étrangère. Notre troisième hypothèse est que l’analyse des représentations des apprenants à l’aide de questionnaire devrait nous éclairer sur les comportements des apprenants et devrait favoriser à affiner certains aspects du dispositif. Les résultats montrent une grande diversité dans les productions des appprenants et proposent des pistes pour l'exploitation des interactions écrites en ligne en classe de langue.L'analyse des représentations des apprenants permet d'avoir une meilleure comprehension des comportements pendant la phase de production.

(ROM 3) – UCL, 2013

Advisors/Committee Members: UCL - LALE - Langues et lettres, Collès, Luc, Dufays, Jean-Louis, Bouillon, Heinz, Maeder, Costantino, Lebrun, Marcel, Mangenot, François.

Subjects/Keywords: Didactique; FLE; Technologie; Interactions écrites

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Noyon, C. (2013). Les interactions écrites en ligne en classe de français langue étrangère : élaboration d’un dispositif, analyse des discours produits et analyse des représentations. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/133397

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Noyon, Christian. “Les interactions écrites en ligne en classe de français langue étrangère : élaboration d’un dispositif, analyse des discours produits et analyse des représentations.” 2013. Thesis, Université Catholique de Louvain. Accessed April 18, 2021. http://hdl.handle.net/2078.1/133397.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Noyon, Christian. “Les interactions écrites en ligne en classe de français langue étrangère : élaboration d’un dispositif, analyse des discours produits et analyse des représentations.” 2013. Web. 18 Apr 2021.

Vancouver:

Noyon C. Les interactions écrites en ligne en classe de français langue étrangère : élaboration d’un dispositif, analyse des discours produits et analyse des représentations. [Internet] [Thesis]. Université Catholique de Louvain; 2013. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/2078.1/133397.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Noyon C. Les interactions écrites en ligne en classe de français langue étrangère : élaboration d’un dispositif, analyse des discours produits et analyse des représentations. [Thesis]. Université Catholique de Louvain; 2013. Available from: http://hdl.handle.net/2078.1/133397

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Bazm, Mohammad Mahdi. Unified isolation architecture and mechanisms against side channel attacks for decentralized cloud infrastructures : Architecture d’isolation unifiée et mécanismes de lutte contre les canaux auxiliaires pour infrastructures cloud décentralisées.

Degree: Docteur es, Sécurité informatique, 2019, Nantes

URL: http://www.theses.fr/2019NANT4042

►

Depuis les travaux de Ristenpart [Ristenpart et al., 2009], les attaques par canaux auxiliaires se sont imposées comme un enjeu sécurité important pour les environnements… (more)

▼

Depuis les travaux de Ristenpart [Ristenpart et al., 2009], les attaques par canaux auxiliaires se sont imposées comme un enjeu sécurité important pour les environnements virtualises, avec une amélioration rapide des techniques d’attaque, et de nombreux travaux de recherche pour les détecter et s’en prémunir. Ces attaques exploitent le partage de ressources matérielles comme les différents niveaux de cache processeur entre des locataires multiples en utilisant la couche de virtualisation. Il devient alors possible d’en contourner les mécanismes de sécurité entre différentes instances virtualisées, par exemple pour obtenir des informations sensibles comme des clés cryptographiques. L’analyse des défis d’isolation et des formes d’attaques par canaux auxiliaires basées sur le cache dans les infrastructures virtualisées met en évidence différentes approches pour les détecter ou les contrer, entre machines virtuelles ou conteneurs Linux. Ces approches se distinguent selon la couche logicielle ou seront appliquées les contre-mesures, applicative, système ou matérielle. La détection reste principalement effectuée au niveau de la couche système ou de virtualisation, ce niveau permettant simplement d’analyser le comportement des instances virtualisées. De nouvelles formes distribuées d’attaques ont aussi pu être mises en évidence. Pour la détection, nous explorons une approche combinant des compteurs de performance matériels (HPCs) et la technologie Intel CMT (Cache Monitoring Technology), s’appuyant également sur la détection d’anomalies pour identifier les machines virtuelles ou les conteneurs malveillants. Les résultats obtenus montrent un taux élevé de détection d’attaques. Pour la réaction, nous proposons une approche de Moving Target Defense (MTD) pour interrompre une attaque entre deux conteneurs Linux, ce qui permet de rendre la configuration du système plus dynamique et plus difficilement attaquable, a différents niveaux du système et du cloud. Cette approche ne nécessite pas d’apporter de modification dans l’OS invite ou dans l’hyperviseur, avec de plus un surcoût très faible en performance. Nous explorons enfin l’utilisation de techniques d’exécution matérielle a base d’enclaves comme Intel SGX (Software Guard Extensions) pour assurer une exécution repartie de confiance de conteneurs Linux sur des couches logicielles qui ne le sont pas nécessairement. Ceci s’est traduit par la proposition d’un modèle d’exécution repartie sur infrastructure Fog pour conteneurs Linux. Il s’agit d’un premier pas vers une infrastructure repartie sécurisée Fog illustrant le potentiel de telles technologies.

Since their discovery by Ristenpart [Ristenpart et al., 2009], the security concern of sidechannelattacks is raising in virtualized environments such as cloud computing infrastructuresbecause of rapid improvements in the attack techniques. Therefore, the mitigationand the detection of such attacks have been getting more attention in these environments,and consequently have been the subject of intense research works.These attacks…

Advisors/Committee Members: Südholt, Mario (thesis director), Menaud, Jean-Marc (thesis director), Lacoste, Marc (thesis director).

Subjects/Keywords: HPCs; Technologie Intel CMT; 005.8

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bazm, M. M. (2019). Unified isolation architecture and mechanisms against side channel attacks for decentralized cloud infrastructures : Architecture d’isolation unifiée et mécanismes de lutte contre les canaux auxiliaires pour infrastructures cloud décentralisées. (Doctoral Dissertation). Nantes. Retrieved from http://www.theses.fr/2019NANT4042

Chicago Manual of Style (16^th Edition):

Bazm, Mohammad Mahdi. “Unified isolation architecture and mechanisms against side channel attacks for decentralized cloud infrastructures : Architecture d’isolation unifiée et mécanismes de lutte contre les canaux auxiliaires pour infrastructures cloud décentralisées.” 2019. Doctoral Dissertation, Nantes. Accessed April 18, 2021. http://www.theses.fr/2019NANT4042.

MLA Handbook (7^th Edition):

Bazm, Mohammad Mahdi. “Unified isolation architecture and mechanisms against side channel attacks for decentralized cloud infrastructures : Architecture d’isolation unifiée et mécanismes de lutte contre les canaux auxiliaires pour infrastructures cloud décentralisées.” 2019. Web. 18 Apr 2021.

Vancouver:

Bazm MM. Unified isolation architecture and mechanisms against side channel attacks for decentralized cloud infrastructures : Architecture d’isolation unifiée et mécanismes de lutte contre les canaux auxiliaires pour infrastructures cloud décentralisées. [Internet] [Doctoral dissertation]. Nantes; 2019. [cited 2021 Apr 18]. Available from: http://www.theses.fr/2019NANT4042.

Council of Science Editors:

Bazm MM. Unified isolation architecture and mechanisms against side channel attacks for decentralized cloud infrastructures : Architecture d’isolation unifiée et mécanismes de lutte contre les canaux auxiliaires pour infrastructures cloud décentralisées. [Doctoral Dissertation]. Nantes; 2019. Available from: http://www.theses.fr/2019NANT4042

19. Gamba, Ines De Abreu. A visão docente do processo de inclusão de um laptop por aluno em duas escolas públicas do ensino fundamental I.

Degree: 2013, Universidade Tecnológica Federal do Paraná; Curitiba; Programa de Pós-Graduação em Tecnologia

URL: http://repositorio.utfpr.edu.br/jspui/handle/1/792

►

As atividades humanas estão interligadas nas relações sociais, culturais, econômicas e políticas. Na educação essas relações existem muito antes de a modernidade se aproximar. Modernidade… (more)

▼

As atividades humanas estão interligadas nas relações sociais, culturais, econômicas e políticas. Na educação essas relações existem muito antes de a modernidade se aproximar. Modernidade aqui entendida em relação aos artefatos tecnológicos como os computadores, as tecnologias de informação e comunicação, potencializadas pela internet e mais recentemente pelos computadores portáteis que são referenciados como “laptops educacionais”, que estão presentes no ambiente escolar, mostrando as novas demandas vivenciadas pela escola e refletindo essas relações. Relações estas que enfatizam o trabalho coletivo no processo de aprendizagem, que retratam a relação do aluno e do professor com o ambiente escolar, com os computadores e com informações por meio da internet. Neste processo em que a interação aparece, pode-se fortalecer a autonomia e a aprendizagem de procedimentos e atividades de cooperação, responsabilidade, interdependência entre outras. O objetivo deste estudo foi analisar a visão dos docentes de duas escolas públicas do ensino fundamental I do Município de Canoinhas (SC), sobre a inclusão de um laptop por aluno no processo de ensino/aprendizagem na sala de aula. O estudo se justifica pela importância do tema e pela necessidade de estudos empíricos que possam mostrar as situações potencialmente capazes de transformar e/ou consolidar as visões existentes sobre o uso desse recurso tecnológico no cotidiano escolar dos professores. A metodologia utilizada foi o estudo de caso intrínseco exploratório. Essa abordagem é utilizada quando o pesquisador deseja explorar com maior profundidade questões pouco conhecidas. Os dados foram coletados em duas fases: na primeira fase, fez-se uma análise documental do Projeto Aprende Canoinhas e dos Projetos Políticos-Pedagógicos das escolas; na segunda fase, foram conduzidas entrevistas individuais semiestruturadas com todas as professoras (14) das duas escolas. Os principais resultados mostram que o papel da equipe gestora no processo de inserção de um laptop por aluno foi fundamental no sentido de preparar o ambiente e incentivar o uso dos laptops pelas professoras e pelos alunos no processo de ensino/aprendizagem. Houve a melhora na comunicação entre as docentes, e boa parte do processo de aprendizagem vivenciado com o uso dos laptops pelas docentes dependeu do perfil participativo das escolas, que, no geral, possuem docentes que se ajudam mutuamente. O uso dos laptops na prática pedagógica propiciou referências para o planejamento das ações docentes. Neste sentido, o planejamento para as atividades com o uso do laptop ocorre de uma forma bem simples, que se adéqua ao planejamento normal, que as docentes já estão acostumadas a realizar no dia a dia escolar.

The human activities are interconnected in the social, cultural, economic and political relations. In education, those relationships interact much before the arrival of modernity. Modernity here understood as technological artifacts such as computers, and information and communication technologies empowered by the internet…

Advisors/Committee Members: Moreira, Herivelto.

Subjects/Keywords: Tecnologia educacional; Computadores; Tecnologia; Educational technology; Computers; Technology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gamba, I. D. A. (2013). A visão docente do processo de inclusão de um laptop por aluno em duas escolas públicas do ensino fundamental I. (Masters Thesis). Universidade Tecnológica Federal do Paraná; Curitiba; Programa de Pós-Graduação em Tecnologia. Retrieved from http://repositorio.utfpr.edu.br/jspui/handle/1/792

Chicago Manual of Style (16^th Edition):

Gamba, Ines De Abreu. “A visão docente do processo de inclusão de um laptop por aluno em duas escolas públicas do ensino fundamental I.” 2013. Masters Thesis, Universidade Tecnológica Federal do Paraná; Curitiba; Programa de Pós-Graduação em Tecnologia. Accessed April 18, 2021. http://repositorio.utfpr.edu.br/jspui/handle/1/792.

MLA Handbook (7^th Edition):

Gamba, Ines De Abreu. “A visão docente do processo de inclusão de um laptop por aluno em duas escolas públicas do ensino fundamental I.” 2013. Web. 18 Apr 2021.

Vancouver:

Gamba IDA. A visão docente do processo de inclusão de um laptop por aluno em duas escolas públicas do ensino fundamental I. [Internet] [Masters thesis]. Universidade Tecnológica Federal do Paraná; Curitiba; Programa de Pós-Graduação em Tecnologia; 2013. [cited 2021 Apr 18]. Available from: http://repositorio.utfpr.edu.br/jspui/handle/1/792.

Council of Science Editors:

Gamba IDA. A visão docente do processo de inclusão de um laptop por aluno em duas escolas públicas do ensino fundamental I. [Masters Thesis]. Universidade Tecnológica Federal do Paraná; Curitiba; Programa de Pós-Graduação em Tecnologia; 2013. Available from: http://repositorio.utfpr.edu.br/jspui/handle/1/792

20. Soraya Guimarães da Silva. Pressupostos ontológicos para se pensar a nova tecnologia: técnica, informação e ser e tempo.

Degree: 2006, Universidade Federal do Rio Grande do Norte

URL: http://bdtd.bczm.ufrn.br/tedesimplificado//tde_busca/arquivo.php?codArquivo=1550

►

La recherche presentée, realisée sur le domaine de la méthaphysique, sagit de rassembler des pressupositions pour une fondamentation ontologique de la technologie de lInformation, basé… (more)

▼

La recherche presentée, realisée sur le domaine de la méthaphysique, sagit de rassembler des pressupositions pour une fondamentation ontologique de la technologie de lInformation, basé sur la philophie de Martin Heidegger; foncièrement, sur lanalytique existentiel du Dasein dans louvrage Être et Temps. À partir de la pensée sur ce qui est aujourdhui, il sagit dinvestiguer sur quels fondaments la Nouvelle Tecnologie se fut érigée de façon a que nous sommes engajés au projet de numérisation des étants que en même temps que destine lhomme a loubli de lÊtre, loffre la possibilité de transformation. Le rapport entre la question de lÊtre et la question de la technique est analysé comme des chemins croisés et dans ce carrefour il devient possible penser ce qui est technique, ce qui est information pour Heidegger et de quel façon les modes existentiels du Dasein sont prêtes pour caractériser l homme au sein de la tecnologie de linformation. Par cette appropriation, il reste penser comment cest possible louverture dune perspective de reconduction de lhomme à la vérité de lÊtre. Finalement, la structuration des fondements rends possible la réflexion discursive général: avec qui nous nous ocuppons, comme nous sommes, dans quelle direction nous nous acheminons, les thèmes générales, respectivement, des trois chapitres. Les points dinvestigation du premier chapitre son: a) La caractérisation précise du Dasein, appuyé sur des considerations de Benedito Nunes, Hans-Georg Gadamer, Jacques Derrida et Rüdiger Safränski; b) Le concept de technique et son essence chez Heidegger; c) la distinction entre technique et technologie, appuyé sur le pensée de J. Ellul, Michel Séris, Otto Pöggeler, Michel Haar, Dominique Janicaud; c) Le concept de cibernetique chez Heidegger et chez Norbert Wiener; d) La caractérisation preliminaire dinformation, lanalyse étimologique e philosophique, lavis de Heidegger te les théories de Rafael Capurro; f) LAnalyse du phénomène de la numérisation des étants, des considérations de Virilio, et lanalyse dun concept de virtuel avec Henri Bergson et Gilles Deleuze. Dans le deuxième chapitre, lanalyse des existentiels du Dasein vers le sommaire des fondements de base pour la caractérisation de la technologie de linformation comme un problème philosophique. Finalement, aprés avoir presenté les concepts introdutoires que délimitent le questionement, suivi par les indications et pressupositions ontologiques trouvés sur Être et Temps, le troisième chapitre disserte sur le péril, ce qui sauve et la sérénité, les trois mots-clés de la pensée heideggerienne sur la technique que permettent lapproche conclusif de la question

A presente pesquisa, realizada no campo da metafísica, reúne pressupostos para uma fundamentação ontológica da Tecnologia da Informação, baseados na filosofia de Martin Heidegger, mais especificamente, na analítica existencial do Dasein na obra Ser e Tempo. A partir do pensar sobre aquilo que hoje é, procurou-se investigar sobre que fundações está erguida a Nova Tecnologia para que estejamos hoje…

Advisors/Committee Members: Glenn Walter Erickson, Jorge Luiz Rocha de Vasconcellos, Oscar Federico Bauchwitz.

Subjects/Keywords: Técnica; Informação; Heidegger; Dasein; Tecnologia da informação; METAFISICA; Technique; Information; Heidegger; Dasein; Technologie de linformation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, S. G. d. (2006). Pressupostos ontológicos para se pensar a nova tecnologia: técnica, informação e ser e tempo. (Thesis). Universidade Federal do Rio Grande do Norte. Retrieved from http://bdtd.bczm.ufrn.br/tedesimplificado//tde_busca/arquivo.php?codArquivo=1550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Silva, Soraya Guimarães da. “Pressupostos ontológicos para se pensar a nova tecnologia: técnica, informação e ser e tempo.” 2006. Thesis, Universidade Federal do Rio Grande do Norte. Accessed April 18, 2021. http://bdtd.bczm.ufrn.br/tedesimplificado//tde_busca/arquivo.php?codArquivo=1550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Silva, Soraya Guimarães da. “Pressupostos ontológicos para se pensar a nova tecnologia: técnica, informação e ser e tempo.” 2006. Web. 18 Apr 2021.

Vancouver:

Silva SGd. Pressupostos ontológicos para se pensar a nova tecnologia: técnica, informação e ser e tempo. [Internet] [Thesis]. Universidade Federal do Rio Grande do Norte; 2006. [cited 2021 Apr 18]. Available from: http://bdtd.bczm.ufrn.br/tedesimplificado//tde_busca/arquivo.php?codArquivo=1550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva SGd. Pressupostos ontológicos para se pensar a nova tecnologia: técnica, informação e ser e tempo. [Thesis]. Universidade Federal do Rio Grande do Norte; 2006. Available from: http://bdtd.bczm.ufrn.br/tedesimplificado//tde_busca/arquivo.php?codArquivo=1550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Gilda Pereira da Silva. Tecnologia Assistiva como apoio à ação docente.

Degree: 2012, HACKEADO! By @PACKETXGROUP

URL: http://tede.unoeste.br/tede/tde_busca/arquivo.php?codArquivo=361

►

A presente pesquisa teve por objetivo analisar a utilização de Tecnologia Assistiva na escolarização de crianças com Necessidades Educacionais Especiais (NEE). O método utilizado foi… (more)

▼

A presente pesquisa teve por objetivo analisar a utilização de Tecnologia Assistiva na escolarização de crianças com Necessidades Educacionais Especiais (NEE). O método utilizado foi estudo de caso com abordagem qualitativa, cujos participantes foram uma aluna com NEE (paralisia cerebral), a professora da educanda, especialista da área de educação especial e oito professores que atuam na sala de aula do ensino regular. A coleta de dados ocorreu mediante a observação de 16 sessões na sala de aula do Apoio Especializado Itinerante (AEI) de uma escola pública e aplicação de questionário, com questões abertas, a professores da sala regular de ensino nas áreas específicas do Currículo do Estado de São Paulo. Os resultados indicaram que em atendimento especializado, a Tecnologia Assistiva permite a acessibilidade das crianças com necessidades especiais, com bom aproveitamento, a diferentes atividades educacionais; professores do ensino regular revelaram determinada resistência à inclusão, pela ausência de formação continuada extensiva aos docentes não especialistas; as Tecnologias Assistivas são pouco conhecidas pelos professores que atuam na sala de aula do ensino regular.

This study aimed to analyze the use of Assistive Technology in education of children with special educational needs. The method used was case study with a qualitative approach, the participants were a student with special educational needs (cerebral palsy), Professor of educanda specialist area and eight special education teachers working in the classroom regular education. The data was collected through observation of 16 sessions in the classroom Itinerant Support Specialist for a public school and a questionnaire with open questions, the regular classroom teachers teaching in specific areas of the curriculum of the State of São Paulo. The results indicated that in specialized care, assistive technology enables accessibility to children with special needs, with good use, the different educational activities; regular teachers showed determined resistance to inclusion by the absence of extensive ongoing training for teachers not experts; the assistive technologies are not well known by teachers working in the classroom regular education.

Advisors/Committee Members: Adriano Rodrigues Ruiz, Carmen Lúcia Dias, Olinda Teruko Kajihara.

Subjects/Keywords: Specialized care; Accessibility.; EDUCACAO; Tecnologia Assistiva; Inclusão; Atendimento especializado; Acessibilidade; Assistive Technologie; Inclusion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, G. P. d. (2012). Tecnologia Assistiva como apoio à ação docente. (Thesis). HACKEADO! By @PACKETXGROUP. Retrieved from http://tede.unoeste.br/tede/tde_busca/arquivo.php?codArquivo=361

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Silva, Gilda Pereira da. “Tecnologia Assistiva como apoio à ação docente.” 2012. Thesis, HACKEADO! By @PACKETXGROUP. Accessed April 18, 2021. http://tede.unoeste.br/tede/tde_busca/arquivo.php?codArquivo=361.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Silva, Gilda Pereira da. “Tecnologia Assistiva como apoio à ação docente.” 2012. Web. 18 Apr 2021.

Vancouver:

Silva GPd. Tecnologia Assistiva como apoio à ação docente. [Internet] [Thesis]. HACKEADO! By @PACKETXGROUP; 2012. [cited 2021 Apr 18]. Available from: http://tede.unoeste.br/tede/tde_busca/arquivo.php?codArquivo=361.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva GPd. Tecnologia Assistiva como apoio à ação docente. [Thesis]. HACKEADO! By @PACKETXGROUP; 2012. Available from: http://tede.unoeste.br/tede/tde_busca/arquivo.php?codArquivo=361

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

22. Santos Oliveira, S. Epidermal growth factor receptor: Target for delivery and silencing.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/32031

► Epidermal growth factor receptor in cancer therapy Recently, cancer research has been able to identify molecular targets that are specific for (or highly expressed by)… (more)

▼ Epidermal growth factor receptor in cancer therapy Recently, cancer research has been able to identify molecular targets that are specific for (or highly expressed by) cancer cells. These molecular targets serve as models for the development of rationally designed anticancer drugs that target important mediators of tumour development. Also, some of these molecular targets have been explored for targeted drug delivery, to ensure that anticancer drugs are specifically delivered to the tumours. The epidermal growth factor receptor (EGFR) is an extensively investigated growth factor and a recognized target for cancer therapy. Many human epithelial cancers overexpress EGFR and the dysregulated EGFR signalling is associated with uncontrolled cell proliferation, inhibition of apoptosis, stimulation of angiogenesis, tissue invasion and metastasis. Two main strategies have been employed to inhibit EGFR: tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs), some of them have already been approved for clinical use. EGFR: target for silencing A different strategy to inhibit EGFR was employed in this thesis. Here, the expression of EGFR protein was interrupted by use of small interfering RNA (siRNA). For efficient gene silencing, siRNA must be delivered intact into the target cell cytoplasm, where RNA interference (RNAi) takes place. Carriers, such as Lipofectamine, are generally used to promote cellular uptake. However, when internalization occurs via endocytosis, the endosomal escape becomes one of the limiting steps for efficient knockdown of the target protein. In this thesis, two different methods were successfully employed to facilitate the endosomal escape of siRNA: an influenza-derived fusogenic peptide and photochemical internalization (PCI). PCI combines a photosensitizer with light to induce photochemical reactions that destabilize endosomal membranes and allow the release of entrapped molecules. PCI was also successfully applied in vivo for enhancing the endosomal escape of anti-EGFR siRNA-Lipofectamine, delivered by intratumoral injection. This study demonstrates that also in vivo endosomal escape is a limiting step that can be facilitated by PCI, improving silencing efficiencies. Local administration of siRNA is not always possible and, therefore, novel targeted drug delivery systems are developed for cancer-specific molecular targets, to direct siRNA and other therapeutic molecules to cancer cells. EGFR: target for delivery Liposomes are attractive delivery systems that have been employed for delivery of a wide range of therapeutic molecules. Liposomes surface has been modified with shielding polymers and targeting ligands that increase their circulation time in the bloodstream and mediate specific target-cell interactions, respectively. In this thesis, a novel targeted drug delivery system was described: anti-EGFR nanobody-liposomes. Nanobodies are the smallest functional antigen binding immunoglobulin fragments that have been isolated from heavy chain-only antibodies, first discovered in camelids.… Advisors/Committee Members: Storm, G, Schiffelers, Raymond.

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos Oliveira, S. (2008). Epidermal growth factor receptor: Target for delivery and silencing. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/32031

Chicago Manual of Style (16^th Edition):

Santos Oliveira, S. “Epidermal growth factor receptor: Target for delivery and silencing.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/32031.

MLA Handbook (7^th Edition):

Santos Oliveira, S. “Epidermal growth factor receptor: Target for delivery and silencing.” 2008. Web. 18 Apr 2021.

Vancouver:

Santos Oliveira S. Epidermal growth factor receptor: Target for delivery and silencing. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/32031.

Council of Science Editors:

Santos Oliveira S. Epidermal growth factor receptor: Target for delivery and silencing. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/32031

Universiteit Utrecht

23. van den Biggelaar, M. Factor VIII trafficking to Weibel-Palade bodies.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/29629

► Summary Factor (F)VIII is an essential cofactor in the enzymatic coagulation cascade. A defect in the gene encoding for FVIII results in the X-linked inherited… (more)

▼ Summary Factor (F)VIII is an essential cofactor in the enzymatic coagulation cascade. A defect in the gene encoding for FVIII results in the X-linked inherited bleeding disorder hemophilia A. In the circulation, FVIII is protected from proteolytic degradation and premature clearance by forming a complex with its carrier protein von Willebrand factor (VWF). While the complex of FVIII and VWF involves one of the strongest protein-protein interactions in the human body, it has remained unclear when and where FVIII and VWF first interact. The most widely accepted view is that FVIII and VWF are secreted from different cells and form a complex in the circulation, merely by virtue of their high-affinity interaction. During the last decade however, increasing evidence has been presented that suggests that the human body should also comprise a releasable storage pool of both proteins. In this thesis, we have studied the relationship between high-affinity interaction in the circulation and intracellular co-storage of FVIII and VWF. We have taken a new approach towards this issue by creating fluorescently tagged VWF and FVIII proteins that are established as being deficient in high-affinity interaction. We have demonstrated that FVIII is stored in VWF-containing storage organelles in absence of high-affinity interaction and that the extent of FVIII storage is independent of its affinity for VWF. In addition, we studied the therapeutic benefit of intracellular co-expression of FVIII and VWF in terms of potential treatment options for hemophilia A. We have shown that blood outgrowth endothelial cells can produce high levels of functional FVIII over a prolonged period of time. In addition, we have demonstrated that a substantial amount of FVIII can be stored in VWF-containing storage organelles whereas the majority of FVIII is released in a constitutive manner. From our data, we conclude that the structural requirements that determine high-affinity interaction between FVIII and VWF in the circulation differ from those that determine intracellular co-trafficking. Our data provide a molecular explanation for the fact that hemophilia A and von Willebrand’s disease patients that suffer from impaired complex assembly of FVIII and VWF in the circulation show concomitant increase of FVIII and VWF plasma levels following treatment with desmopressin. The mechanism that determines FVIII storage in VWF-containing granules as well as the therapeutic potential of FVIII expression in VWF producing cells now awaits further exploration. Advisors/Committee Members: Mertens, Koen, Storm, G, Voorberg, J., Kootstra, N.A..

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

van den Biggelaar, M. (2008). Factor VIII trafficking to Weibel-Palade bodies. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/29629

Chicago Manual of Style (16^th Edition):

van den Biggelaar, M. “Factor VIII trafficking to Weibel-Palade bodies.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/29629.

MLA Handbook (7^th Edition):

van den Biggelaar, M. “Factor VIII trafficking to Weibel-Palade bodies.” 2008. Web. 18 Apr 2021.

Vancouver:

van den Biggelaar M. Factor VIII trafficking to Weibel-Palade bodies. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/29629.

Council of Science Editors:

van den Biggelaar M. Factor VIII trafficking to Weibel-Palade bodies. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/29629

Universiteit Utrecht

24. Oudshoorn, M.H.M. Composite of microgels and lipids as biofilm to restore skin barrier function.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/29883

► The mature epidermis is an effective barrier which prevents the body from dehydration and protects it against various environmental influences. If the natural barrier is… (more)

▼ The mature epidermis is an effective barrier which prevents the body from dehydration and protects it against various environmental influences. If the natural barrier is immature or damaged, the skin barrier is impaired and desiccation occurs. Hence, the regeneration of impaired skin is an essential process for survival. In patients, the natural recovery is sometimes rather slow, in particular in the cases of large defects. To support skin regeneration, a large variety of skin creams is presently available, aiming to modify the hydration level of the skin and to protect the body against excessive water loss and thus to enhance epidermal barrier function. However, these creams clearly have a different structure than stratum corneum (SC), resulting in low water binding capacity and uncontrolled hydration of the skin. The basic mechanism of these skin creams is that they act as moisturizer and increase the hydration of SC by either blocking the TEWL (transepidermal water loss) or by delivering exogenous hygroscopic substances to the SC. Therefore, it has been suggested that the development of barrier creams with high water-holding capacity and thus controlled water transport, such as the natural cream VC (vernix caseosa), might help in the development and/or restoration of the SC barrier. The aim of this thesis was the development of a new generation of skin-surface biofilms, combining the structure and properties of VC, to protect diseased, dry and premature skin and to facilitate wound healing. These biofilms were based on synthetic cells embedded in a lipid matrix. The synthetic cells consisted of crosslinked hydrophilic polymers (hydrogels) with similar size and shape as natural corneocytes. Combined with the work of Rissmann (presented in thesis R. Rissmann), who focused on the development of a synthetic lipid mixture, we were able to prepare biofilms. The biofilms were prepared by mixing the synthetic corneocytes with the lipid matrix. These biofilms were characterized and optimized to mimic VC. Various biofilms were applied topically on disrupted mouse skin to investigate their effect on superficial wound healing. All formulations promoted a rapid formation of SC and prevented epidermal hyperproliferation. In general the synthetic VC analogues showed strong effects concerning the recovery rate, however, only one biofilm mimicked the effects of native VC the most closely. In conclusion, this thesis describes the development of a new generation of skin-surface biofilms mimicking closely the structure and properties of VC. These biofilms act as skin protectants and facilitate the restoration of the SC barrier. These unique systems have therefore great potential to protect diseased, dry and premature skin and to facilitate wound healing in humans. Advisors/Committee Members: Hennink, Wim, Bouwstra, J.A..

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oudshoorn, M. H. M. (2008). Composite of microgels and lipids as biofilm to restore skin barrier function. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/29883

Chicago Manual of Style (16^th Edition):

Oudshoorn, M H M. “Composite of microgels and lipids as biofilm to restore skin barrier function.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/29883.

MLA Handbook (7^th Edition):

Oudshoorn, M H M. “Composite of microgels and lipids as biofilm to restore skin barrier function.” 2008. Web. 18 Apr 2021.

Vancouver:

Oudshoorn MHM. Composite of microgels and lipids as biofilm to restore skin barrier function. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/29883.

Council of Science Editors:

Oudshoorn MHM. Composite of microgels and lipids as biofilm to restore skin barrier function. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/29883

Universiteit Utrecht

25. de Graaf, A.J. Self-assembled materials from thermosensitive and biohybrid block copolymers.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/234839

► In this research, several block copolymers were synthesized and characterized with regard to possible pharmaceutical applications. All block copolymers were thermosensitive and self-assembled at 37… (more)

▼ In this research, several block copolymers were synthesized and characterized with regard to possible pharmaceutical applications. All block copolymers were thermosensitive and self-assembled at 37 °C into structures like micelles and hydrogels, which can be used for innovative drug delivery purposes. Some of the synthesized polymers were biohybrid, in the sense that they contained peptide segments which enabled their cleavage by enzymes that are upregulated in diseased tissues. First, methods were explored for the synthesis of polymer (bio)conjugates. One suitable and popular reaction for synthesizing such conjugates is the copper-catalyzed azide-alkyne cycloaddition ‘click’ reaction. A novel method was developed to introduce a reactive azide functionality on polymers after their synthesis by Atom Transfer Radical Polymerization (ATRP). The newly developed reaction is catalyzed by the ATRP copper catalyst and can be followed by a ‘click’ conjugation reaction using again the same catalyst. Another, relatively new, method to synthesize polymer bioconjugates is to grow a polymer from a peptide or protein. In this research, a peptide containing an enzymatic cleavage site for the tumor-associated matrix metalloproteases (MMPs) 2 and 9 was functionalized at its C-terminus with an ATRP initiator, followed by the polymerization of a hydrophilic polymer block, poly(oligo(ethylene glycol) methyl ether metharcrylate).Then, another ATRP initiator was conjugated to the N-terminus of the peptide followed by the polymerization of a thermosensitive block, poly(N-isopropylacrylamide). At 37 °C in water, all polymers formed micelles with a favorable size for drug delivery purposes. It was shown that the coronas of the micelles could be cleaved off enzymatically. This system may function as a long-circulating drug delivery vehicle with enzyme-triggered destabilization in the target tissue to release e.g. a cytotoxic payload. Subsequently, a study of the physico-chemical differences between ‘star-like’ micelles and ‘flower-like micelles’ was performed. Star-like micelles are formed from amphiphilic diblock copolymers, whereas flower-like micelles are formed from triblock copolymers that consist of two hydrophobic blocks separated by a hydrophilic block. Both Static Light Scattering and 1H NMR T2 relaxation measurements indicated that hydrophilic polymer blocks in flower-like micelles are less flexible than in star-like micelles. The last part of this research focused on a particular property of flower-like micelles, namely the fact that at high concentration they are in equilibrium with a hydrogel. When a thermosensitive triblock copolymer hydrogel was brought into water, flower-like micelles were released. When the hydrogel was pre-loaded with the cytostatic drug paclitaxel, this was co-released with the micelles. The system was tested in a tumor xenograft mouse model: paclitaxel-loaded hydrogels were injected i.p., after which paclitaxel was slowly released and could be measured in the circulation for two days. Furthermore, the… Advisors/Committee Members: Hennink, Wim, Mastrobattista, Enrico, Vermonden, Tina.

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

de Graaf, A. J. (2012). Self-assembled materials from thermosensitive and biohybrid block copolymers. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/234839

Chicago Manual of Style (16^th Edition):

de Graaf, A J. “Self-assembled materials from thermosensitive and biohybrid block copolymers.” 2012. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/234839.

MLA Handbook (7^th Edition):

de Graaf, A J. “Self-assembled materials from thermosensitive and biohybrid block copolymers.” 2012. Web. 18 Apr 2021.

Vancouver:

de Graaf AJ. Self-assembled materials from thermosensitive and biohybrid block copolymers. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2012. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/234839.

Council of Science Editors:

de Graaf AJ. Self-assembled materials from thermosensitive and biohybrid block copolymers. [Doctoral Dissertation]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/234839

Universiteit Utrecht

26. Filipe, V.L.S. Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/240480

► Therapeutic proteins have become invaluable in treating a wide range of serious and life-threatening diseases. However, repeated administration of these drugs to patients often induces… (more)

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Filipe, V. L. S. (2012). Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/240480

Chicago Manual of Style (16^th Edition):

Filipe, V L S. “Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity.” 2012. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/240480.

MLA Handbook (7^th Edition):

Filipe, V L S. “Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity.” 2012. Web. 18 Apr 2021.

Vancouver:

Filipe VLS. Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2012. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/240480.

Council of Science Editors:

Filipe VLS. Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity. [Doctoral Dissertation]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/240480

Universiteit Utrecht

27. Stavenuiter, F. Factor seven activating protease : in search of a physiological role.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/179070

► Since its discovery in 1996, numerous functions have been proposed for Factor VII-activating protease (FSAP) including interactions with the haemostatic system. These include activation of… (more)

Subjects/Keywords: Farmacie; Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stavenuiter, F. (2010). Factor seven activating protease : in search of a physiological role. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/179070

Chicago Manual of Style (16^th Edition):

Stavenuiter, F. “Factor seven activating protease : in search of a physiological role.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/179070.

MLA Handbook (7^th Edition):

Stavenuiter, F. “Factor seven activating protease : in search of a physiological role.” 2010. Web. 18 Apr 2021.

Vancouver:

Stavenuiter F. Factor seven activating protease : in search of a physiological role. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/179070.

Council of Science Editors:

Stavenuiter F. Factor seven activating protease : in search of a physiological role. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/179070

Universiteit Utrecht

28. van Gaal, E.V.B. DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/180021

► The aim of gene therapy is to treat, cure or prevent a disease by replacing defective genes, introducing new genes or changing the expression of… (more)

▼ The aim of gene therapy is to treat, cure or prevent a disease by replacing defective genes, introducing new genes or changing the expression of a person’s genes. Success of gene therapy is dependent on successful delivery of DNA from the site of administration into cell nuclei. Naturally occurring and highly efficient gene delivery systems are viruses. However, issues of safety, limited targeting possibilities and limited loading capacity justify the search for safe and flexible synthetic (non-viral) alternatives. Despite numerous efforts, success of non-viral gene delivery is hampered due to four major problems: toxicity, short-lived expression, heterogeneity of expression and low efficiency. The aim of this thesis is to rationally design DNA-Transporting Nanoparticles (DTN), focusing on three levels: (1) design of DNA to increase safety, efficiency and duration of transgene expression, (2) design of formulations to increase efficiency of transfection and (3) development of methods to allow better analysis of DTN. First it is shown how rational design of plasmid DNA can increase safety, efficiency and duration of transgene expression. Next, two strategies to improve nuclear uptake of DTN are examined. The first strategy involves modification of plasmid with DNA nuclear Targeting Sequences (DTS) which would facilitate nuclear localization by inducing coating of plasmid DNA with nuclear localization signals (NLS)-containing proteins and subsequent binding to importins. Modification of plasmids with DTS was not shown to increase gene expression, regardless of the cell line, dose and carrier system chosen, indicating that a bottleneck exists downstream of nuclear delivery. The second strategy was based on the non-covalent coupling of NLS-peptides to DNA. Peptides were shown to enhance transfection efficiency, but in an NLS-independent way. Next, the number of plasmids per DTN is addressed. The amount of active DNA could be reduced substantially while maintaining transfection activity by replacing active DNA with non-coding junk DNA. The results indicate that not the total amount of DNA, but the number of active DNA-containing particles is the critical factor in determining transfection efficiency. Size of DTN is a critical parameter, but preparation of DTN generally yields heterogeneously sized populations. Additionally, the size of DTN is affected by exposure to salts and proteins. A new method based on flow cytometry was developed to measure particle size distributions directly in biological fluids. Simultaneous detection of fluorescence and side scattering intensity (SSC ; indicative of size) provided the possibility to distinguish fluorescently labeled nanoparticles of interest from other particulate matter frequently present in biological fluid. Additionally, a proof of principle to sort heterogeneous populations into different size fractions was obtained. Testing of new gene delivery reagents is usually performed by reading out transgene expression levels relative to a reference formulation after in vitro… Advisors/Committee Members: Crommelin, Daniel, Hennink, Wim, Mastrobattista, Enrico, Oosting, Ronald.

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

van Gaal, E. V. B. (2010). DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/180021

Chicago Manual of Style (16^th Edition):

van Gaal, E V B. “DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/180021.

MLA Handbook (7^th Edition):

van Gaal, E V B. “DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery.” 2010. Web. 18 Apr 2021.

Vancouver:

van Gaal EVB. DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/180021.

Council of Science Editors:

van Gaal EVB. DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/180021

Universiteit Utrecht

29. Censi, R. Temperature sensitive hydrogels for protein delivery and tissue engineering.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/187371

► Hydrogels are water-swollen polymeric materials able to maintain a distinct three-dimensional structure. They were the first biomaterials designed for clinical use in the early 1950s,… (more)

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Censi, R. (2010). Temperature sensitive hydrogels for protein delivery and tissue engineering. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/187371

Chicago Manual of Style (16^th Edition):

Censi, R. “Temperature sensitive hydrogels for protein delivery and tissue engineering.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/187371.

MLA Handbook (7^th Edition):

Censi, R. “Temperature sensitive hydrogels for protein delivery and tissue engineering.” 2010. Web. 18 Apr 2021.

Vancouver:

Censi R. Temperature sensitive hydrogels for protein delivery and tissue engineering. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/187371.

Council of Science Editors:

Censi R. Temperature sensitive hydrogels for protein delivery and tissue engineering. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/187371

Universiteit Utrecht

30. Sauerborn, M.S. Immunological aspects of antibody formation against recombinant human therapeutics.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/188116

► With about 200 new products in the pipeline, recombinant human (rh) therapeutics are becoming the most dominant class of drugs. One of the reasons to… (more)

▼ With about 200 new products in the pipeline, recombinant human (rh) therapeutics are becoming the most dominant class of drugs. One of the reasons to create rh therapeutics was to avoid recognition by the immune system due to foreign origin. Nevertheless, rh therapeutics induced formation of anti-drug antibodies. Aggregation of the therapeutic protein became a major concern, directing the focus on an ancient mechanism of the immune system to recognize repetitive epitopes on pathogens and activation of a non-classical T-cell – B-cell pathway leading to a fast and efficient immune response. It was hypothesized that aggregated rh therapeutics mimic such repetitive epitope carrying pathogens, named T cell independent type 2 antigens. The thesis entitles ‘Immunological aspects of antibody formation against recombinant human therapeutics’ investigated the immunological mechanisms triggered after administration of aggregated rh therapeutics in transgenic mice immune tolerant for the therapeutic of interest. A three step approach was used: (I) Memory formation after administration of aggregated rh therapeutics?, (II) Is the response T cell independent?, (III) Do Marginal Zone B cells influence the immune response against rh therapeutics?. Two model therapeutics were used: (1) rh interferon beta, and (2) recombinant human interferon alpha. Both models showed the absence of memory formation after initial challenge and boost with both aggregated and non-aggregated rh drugs. In addition, a lack of neutralizing antibodies was observed. Though memory was absent, animals had an abundant pool of isotype switched antibodies, a sign for T cell dependency. And indeed, depletion of CD4+ T cells led to a complete abolishment of the antibody formation against aggregated therapeutic. Lastly, it could be shown that the depletion of marginal zone B cells influence the response against rh therapeutics. In conclusions, it was shown that the immune response directed against aggregated rh therapeutics is neither comparable to a classical nor to a T cell independent type 2 antigen. In addition, the presence of naturally occurring antibodies in human blood samples was investigated. It is hypothesized that patients having natural occurring antibodies against a rh therapeutic may be more susceptible to formation of anti-drug antibodies when treated with the rh therapeutic. The presence of naturally occurring antibodies against interferon alpha, beta and gamma and bone morphogenetic proteins 2 and 7 could be found in around 2% of individuals (n=400). Their influence on the immunogenicity of rh therapeutics need to be further explored. Advisors/Committee Members: Schellekens, Huub, Jiskoot, W..

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sauerborn, M. S. (2010). Immunological aspects of antibody formation against recombinant human therapeutics. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/188116

Chicago Manual of Style (16^th Edition):

Sauerborn, M S. “Immunological aspects of antibody formation against recombinant human therapeutics.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed April 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/188116.

MLA Handbook (7^th Edition):

Sauerborn, M S. “Immunological aspects of antibody formation against recombinant human therapeutics.” 2010. Web. 18 Apr 2021.

Vancouver:

Sauerborn MS. Immunological aspects of antibody formation against recombinant human therapeutics. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2021 Apr 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/188116.

Council of Science Editors:

Sauerborn MS. Immunological aspects of antibody formation against recombinant human therapeutics. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/188116

Open Access Theses and Dissertations