Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

Sorted by: relevance · author · university · dateNew search

You searched for subject:( side branching). Showing records 1 – 3 of 3 total matches.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


Duquesne University

1. Bondi, Corry Dominic. The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer.

Degree: PhD, Pharmacology-Toxicology, 2013, Duquesne University

The use of hormone replacement therapy (HRT) is important to relieve menopausal symptoms. However, HRT use declined after an increased risk of breast cancer was reported by the Women's Health Initiative. With the ultimate goal of developing a novel replacement therapy to relieve menopausal symptoms without increasing the risk of breast cancer, we postulated that a novel replacement therapy containing 17β-estradiol (E2) and half the recommended dose of progesterone (P4) along with nocturnal melatonin supplementation (EPMRT) would be protective against mammary tumor development. Previously, in a mouse model of HER2+ breast cancer, our laboratory demonstrated that EPMRT was protective against mammary cancer by increasing mammary tumor latency, decreasing tumor incidence and weight, and decreasing gross lung metastases while not increasing uterine weight. A pre-tumor study was conducted to gain insight into these protective effects. Randomized, non-ovariectomized, 60-day old female MMTV/unactivated Neu mice were provided therapies comprised of E2 and P4, with or without nocturnal melatonin supplementation, given continually for 30 days. To investigate actions on mammary tissues, whole mount, microarray, and real-time RT-PCR analyses were performed. To assess impact on the uterus, uterine wet weight, luminal epithelial height, estrogen receptor (ERα) and progesterone receptor (PR) expression, as well as Ki67 expression were performed. Tertiary side-branching, the initial step in the process of mammary ductal differentiation, was significantly increased by Melatonin and EPMRT as compared to Control. Also, EPMRT displayed significantly decreased expression of the cancer-related genes encoding amphiregulin and indoleamine 2, 3-dioxygenase. In the uterus, there were no differences detected in wet weight, luminal epithelial height, and proliferation. Also, there was no effect on serum E2 or P4 levels; however, EPMRT increased the time in estrus. Moreover, the increase in expression of aromatase mRNA by low dose P4 was abolished by increasing doses of P4 and by addition of melatonin. Overall, these data provide important insight into the protective actions of EPMRT on Neu-induced mammary cancer. These findings provide a rationale for future investigations with the ultimate goal of having women use this novel therapy to relieve menopausal symptoms while providing protective actions on the breast and the uterus. Advisors/Committee Members: Paula Witt-Enderby, David Johnson, Jane Cavanaugh, Rehana Leak, Melissa Melan.

Subjects/Keywords: Breast cancer; Gene Expression; Melatonin; MMTV-Neu mice; Tertiary side-branching; Uterus

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bondi, C. D. (2013). The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer. (Doctoral Dissertation). Duquesne University. Retrieved from https://dsc.duq.edu/etd/1540

Chicago Manual of Style (16th Edition):

Bondi, Corry Dominic. “The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer.” 2013. Doctoral Dissertation, Duquesne University. Accessed December 10, 2019. https://dsc.duq.edu/etd/1540.

MLA Handbook (7th Edition):

Bondi, Corry Dominic. “The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer.” 2013. Web. 10 Dec 2019.

Vancouver:

Bondi CD. The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer. [Internet] [Doctoral dissertation]. Duquesne University; 2013. [cited 2019 Dec 10]. Available from: https://dsc.duq.edu/etd/1540.

Council of Science Editors:

Bondi CD. The Addition of Melatonin to 17beta-Estradiol and Progesterone Modulated Markers Relevant to Mammary Tumor Development and Modulated Steroid Receptors Relevant to Uterine Protection in a Mouse Model of Breast Cancer. [Doctoral Dissertation]. Duquesne University; 2013. Available from: https://dsc.duq.edu/etd/1540

2. FONTANA, João Vitor Nogueira. Non-newtonian fluids in a Hele-Shaw cell: a pattern formation study .

Degree: 2014, Universidade Federal de Pernambuco

A instabilidade de Saffman-Taylor se dá na interface entre dois fluidos viscosos no interior de uma célula de Hele-Shaw (CHS). A CHS é um aparato experimental que consiste em duas placas, usualmente planas e paralelas, separadas por uma distância muito pequena. Sabe-se que quando um fluido viscoso desloca outro mais viscoso, em uma CHS, a interface entre eles se torna instável e estruturas chamadas de “dedos viscosos” surgem. Em função da geometria da CHS e da força motriz do fluxo, tais dedos podem bifurcar, afinar, competir em tamanho e interferirem uns com os outros, formando as mais diversas estruturas morfológicas. Estudos com fluidos newtonianos em CHS vêm sendo feitos desde o final do século XIX. No entanto, apenas recentemente, a cerca de trinta anos, estudos com fluidos não newtonianos em CHS vêm sendo conduzidos, e em sua maioria estudos analíticos lineares ou não lineares puramente numéricos. Este trabalho tenta preencher essa lacuna com um estudo analítico não linear de fluidos não newtonianos em CHS. Estudamos a CHS de geometria radial com levantamento da placa superior e injeção como forças motrizes do fluxo. Nestes casos estudamos o fluido yield stress, um tipo especial de fluido não newtoniano que se comporta como um “semissólido”. Estudamos também o fluido power-law que introduz, na viscosidade, uma dependência do fluxo. Em cada caso fomos capazes de estabelecer conexões entre as nossas previsões teóricas e os experimentos e simulações encontrados na literatura. Tais previsões são acerca da estabilidade e morfologia da interface como: bifurcação de dedos, a estrutura conhecida como side branching e a competição entre dedos. Advisors/Committee Members: MIRANDA NETO, José Américo (advisor).

Subjects/Keywords: Célula de Hele-Shaw; fluido não newtoniano; fluido yield stress; fluido power-law; competição de dedos viscosos; side branching

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

FONTANA, J. V. N. (2014). Non-newtonian fluids in a Hele-Shaw cell: a pattern formation study . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/13861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

FONTANA, João Vitor Nogueira. “Non-newtonian fluids in a Hele-Shaw cell: a pattern formation study .” 2014. Thesis, Universidade Federal de Pernambuco. Accessed December 10, 2019. http://repositorio.ufpe.br/handle/123456789/13861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

FONTANA, João Vitor Nogueira. “Non-newtonian fluids in a Hele-Shaw cell: a pattern formation study .” 2014. Web. 10 Dec 2019.

Vancouver:

FONTANA JVN. Non-newtonian fluids in a Hele-Shaw cell: a pattern formation study . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2014. [cited 2019 Dec 10]. Available from: http://repositorio.ufpe.br/handle/123456789/13861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

FONTANA JVN. Non-newtonian fluids in a Hele-Shaw cell: a pattern formation study . [Thesis]. Universidade Federal de Pernambuco; 2014. Available from: http://repositorio.ufpe.br/handle/123456789/13861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


East Tennessee State University

3. Asare, Shardrack O. Optimized Acid/Base Extraction and Structural Characterization of β-glucan from Saccharomyces Cerevisiae.

Degree: MS, Chemistry, 2015, East Tennessee State University

β-glucan is a major component of the fungal cell wall consisting of (1→3)-β linked glucose polymers with (1→6)-β linked side chains. The published classical isolation procedure of β-glucan from Saccharomyces cerevisiae is expensive and time-consuming. Thus, the aim of this research was to develop an effective procedure for the extraction of glucans. We have developed a new method for glucan extraction that will be cost effective and will maintain the native structure of the glucan. The method that we developed is 80% faster and utilizes 1/3 of the reagents compared to the published classical method. Further, the method developed increases the yield from 2.9 % to 10.3 %. Our new process has a branching frequency of 18.4 down from 197 and a side chain of 5.1 up from 2.5. The data indicate a more preserved native structure of isolated glucans.

Subjects/Keywords: Saccharomyces Cerevisiae; Branching frequency; Side Chain Length; Glucan; Extraction Methods; Characterization Methods; NMR spectroscopy.; Analytical Chemistry

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Asare, S. O. (2015). Optimized Acid/Base Extraction and Structural Characterization of β-glucan from Saccharomyces Cerevisiae. (Masters Thesis). East Tennessee State University. Retrieved from https://dc.etsu.edu/etd/2513

Chicago Manual of Style (16th Edition):

Asare, Shardrack O. “Optimized Acid/Base Extraction and Structural Characterization of β-glucan from Saccharomyces Cerevisiae.” 2015. Masters Thesis, East Tennessee State University. Accessed December 10, 2019. https://dc.etsu.edu/etd/2513.

MLA Handbook (7th Edition):

Asare, Shardrack O. “Optimized Acid/Base Extraction and Structural Characterization of β-glucan from Saccharomyces Cerevisiae.” 2015. Web. 10 Dec 2019.

Vancouver:

Asare SO. Optimized Acid/Base Extraction and Structural Characterization of β-glucan from Saccharomyces Cerevisiae. [Internet] [Masters thesis]. East Tennessee State University; 2015. [cited 2019 Dec 10]. Available from: https://dc.etsu.edu/etd/2513.

Council of Science Editors:

Asare SO. Optimized Acid/Base Extraction and Structural Characterization of β-glucan from Saccharomyces Cerevisiae. [Masters Thesis]. East Tennessee State University; 2015. Available from: https://dc.etsu.edu/etd/2513

.