subject:( niacin)

Oregon State University

1. Pederson, Raymond LeRoy. Microbiological assay of nicotinic acid in natural materials.

Degree: MS, Organic Chemistry, 1944, Oregon State University

URL: http://hdl.handle.net/1957/53169

► During the routine determination of the vitamin contents of dehydrated foods, it was observed that nicotine acid values were often lower than expected. The methods… (more)

Subjects/Keywords: Niacin

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APA (6^th Edition):

Pederson, R. L. (1944). Microbiological assay of nicotinic acid in natural materials. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/53169

Chicago Manual of Style (16^th Edition):

Pederson, Raymond LeRoy. “Microbiological assay of nicotinic acid in natural materials.” 1944. Masters Thesis, Oregon State University. Accessed March 05, 2021. http://hdl.handle.net/1957/53169.

MLA Handbook (7^th Edition):

Pederson, Raymond LeRoy. “Microbiological assay of nicotinic acid in natural materials.” 1944. Web. 05 Mar 2021.

Vancouver:

Pederson RL. Microbiological assay of nicotinic acid in natural materials. [Internet] [Masters thesis]. Oregon State University; 1944. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1957/53169.

Council of Science Editors:

Pederson RL. Microbiological assay of nicotinic acid in natural materials. [Masters Thesis]. Oregon State University; 1944. Available from: http://hdl.handle.net/1957/53169

Oregon State University

2. Morley, Nina Hope. Distribution of diphosphopyridine nucleotide in various fractions of blood of human subjects.

Degree: PhD, Home Economics, 1957, Oregon State University

URL: http://hdl.handle.net/1957/50283

Subjects/Keywords: Niacin

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APA (6^th Edition):

Morley, N. H. (1957). Distribution of diphosphopyridine nucleotide in various fractions of blood of human subjects. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/50283

Chicago Manual of Style (16^th Edition):

Morley, Nina Hope. “Distribution of diphosphopyridine nucleotide in various fractions of blood of human subjects.” 1957. Doctoral Dissertation, Oregon State University. Accessed March 05, 2021. http://hdl.handle.net/1957/50283.

MLA Handbook (7^th Edition):

Morley, Nina Hope. “Distribution of diphosphopyridine nucleotide in various fractions of blood of human subjects.” 1957. Web. 05 Mar 2021.

Vancouver:

Morley NH. Distribution of diphosphopyridine nucleotide in various fractions of blood of human subjects. [Internet] [Doctoral dissertation]. Oregon State University; 1957. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1957/50283.

Council of Science Editors:

Morley NH. Distribution of diphosphopyridine nucleotide in various fractions of blood of human subjects. [Doctoral Dissertation]. Oregon State University; 1957. Available from: http://hdl.handle.net/1957/50283

Michigan State University

3. Long, Lora Elizabeth. Effects of excess dietary niacin in high and low fat diets on selective enzyme and coenzyme systems in the rat.

Degree: MS, 1962, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:12162

Subjects/Keywords: Niacin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Long, L. E. (1962). Effects of excess dietary niacin in high and low fat diets on selective enzyme and coenzyme systems in the rat. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:12162

Chicago Manual of Style (16^th Edition):

Long, Lora Elizabeth. “Effects of excess dietary niacin in high and low fat diets on selective enzyme and coenzyme systems in the rat.” 1962. Masters Thesis, Michigan State University. Accessed March 05, 2021. http://etd.lib.msu.edu/islandora/object/etd:12162.

MLA Handbook (7^th Edition):

Long, Lora Elizabeth. “Effects of excess dietary niacin in high and low fat diets on selective enzyme and coenzyme systems in the rat.” 1962. Web. 05 Mar 2021.

Vancouver:

Long LE. Effects of excess dietary niacin in high and low fat diets on selective enzyme and coenzyme systems in the rat. [Internet] [Masters thesis]. Michigan State University; 1962. [cited 2021 Mar 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:12162.

Council of Science Editors:

Long LE. Effects of excess dietary niacin in high and low fat diets on selective enzyme and coenzyme systems in the rat. [Masters Thesis]. Michigan State University; 1962. Available from: http://etd.lib.msu.edu/islandora/object/etd:12162

Penn State University

4. Vrablik, Tracy Lynn. NICOTINAMIDASE MODULATION OF NICOTINAMIDE LEVELS AND NAD+ SYNTHESIS SEPARATELY AFFECT DEVELOPMENT AND PHYSIOLOGY OF MULTIPLE ORGAN SYSTEMS IN C. ELEGANS .

Degree: 2011, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/11736

► Nicotinamide adenine dinucleotide (NAD) is a central molecule in cellular metabolism and an obligate co-substrate for NAD+ consuming enzymes, which regulate key biological processes such… (more)

▼ Nicotinamide adenine dinucleotide (NAD) is a central molecule in cellular metabolism and an obligate co-substrate for NAD+ consuming enzymes, which regulate key biological processes such as longevity and stress responses. While NAD+ biosynthesis has been intensely studied, little analysis has been done in developmental models. I have uncovered novel developmental roles for a nicotinamidase, the first enzyme in the NAD+ salvage pathway of invertebrates. Nicotinamidase activity hydrolyzes nicotinamide (NAM) and shuttles it into the NAD+ salvage pathway, thereby lowering NAM levels and replenishing levels of NAD+. Mutations in the C. elegans nicotinamidase PNC-1 cause developmental and functional defects in the reproductive system: the development of the gonad is delayed, four uterine cells die by necrosis and the mutant animals are egg-laying defective. Through pharmacological analysis of the reproductive defects I determined that regulation of both substrate (NAM) and product (NA/NAD+) level is key to the biological activity of PNC-1. Interestingly, these metabolites function separately, as exogenous NAM in wild-type animals induces the uv1 cell necrosis and egg-laying defects, but not the gonad timing defect. Gonad timing in pnc-1 mutants is rescued by restoring NAD+ salvage. I propose that our C. elegans model is highly relevant to vertebrates. I demonstrate that nicotinamide phosphoribosyltransferase (Nampt), the equivalent enzyme in nicotinamide recycling to NAD+ in vertebrates, can functionally substitute for PNC-1. Nampt is secreted and I identified a secreted isoform of PNC-1 and confirmed its extracellular localization and function in vivo, suggesting a conserved role for extracellular NAD+ synthesis. The NAM-NAD+ salvage pathway is an important myogenic regulator in vertebrates and I uncovered a similar role in muscle development and function in our C. elegans model. C. elegans pnc-1 males have a spicule muscle defect, which prevents them from successfully mating. In collaboration with my colleague Wenqing Wang, we demonstrate muscle-cell-type specificity to perturbations of NAD production and/or NAM levels. In male spicule muscles the role of PNC-1 is to promote NAD+ biosynthesis during development, while in vulval muscles PNC-1 prevents accumulation of NAM. Therefore I postulate an evolutionarily conserved role for NAM to NAD+ salvage pathway modulation of NAM and NAD+ levels in the developmental regulation of multiple tissues. To test our model of metabolite function in development, I quantified the physiological levels of NAM and NAD+ in C. elegans and how these levels respond to genetic and pharmacological perturbations. I found that physiological levels of NAM were elevated in pnc-1 mutants as expected, however NAD+ levels were resistant to perturbation. I hypothesize that organisms maintain NAD+ levels via endocrine or other regulatory mechanisms that modulate NAD+ synthesis and utilization. To provide phylogenetic context to these metabolite levels, I quantified the levels of these… Advisors/Committee Members: Wendy Hanna Rose, Dissertation Advisor/Co-Advisor, Wendy Hanna Rose, Committee Chair/Co-Chair, Melissa Rolls, Committee Member, Zhi Chun Lai, Committee Member, Troy Ott, Committee Member, Squire J Booker, Committee Member.

Subjects/Keywords: NAD+ metabolism; niacin; development

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APA (6^th Edition):

Vrablik, T. L. (2011). NICOTINAMIDASE MODULATION OF NICOTINAMIDE LEVELS AND NAD+ SYNTHESIS SEPARATELY AFFECT DEVELOPMENT AND PHYSIOLOGY OF MULTIPLE ORGAN SYSTEMS IN C. ELEGANS . (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/11736

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vrablik, Tracy Lynn. “NICOTINAMIDASE MODULATION OF NICOTINAMIDE LEVELS AND NAD+ SYNTHESIS SEPARATELY AFFECT DEVELOPMENT AND PHYSIOLOGY OF MULTIPLE ORGAN SYSTEMS IN C. ELEGANS .” 2011. Thesis, Penn State University. Accessed March 05, 2021. https://submit-etda.libraries.psu.edu/catalog/11736.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vrablik, Tracy Lynn. “NICOTINAMIDASE MODULATION OF NICOTINAMIDE LEVELS AND NAD+ SYNTHESIS SEPARATELY AFFECT DEVELOPMENT AND PHYSIOLOGY OF MULTIPLE ORGAN SYSTEMS IN C. ELEGANS .” 2011. Web. 05 Mar 2021.

Vancouver:

Vrablik TL. NICOTINAMIDASE MODULATION OF NICOTINAMIDE LEVELS AND NAD+ SYNTHESIS SEPARATELY AFFECT DEVELOPMENT AND PHYSIOLOGY OF MULTIPLE ORGAN SYSTEMS IN C. ELEGANS . [Internet] [Thesis]. Penn State University; 2011. [cited 2021 Mar 05]. Available from: https://submit-etda.libraries.psu.edu/catalog/11736.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vrablik TL. NICOTINAMIDASE MODULATION OF NICOTINAMIDE LEVELS AND NAD+ SYNTHESIS SEPARATELY AFFECT DEVELOPMENT AND PHYSIOLOGY OF MULTIPLE ORGAN SYSTEMS IN C. ELEGANS . [Thesis]. Penn State University; 2011. Available from: https://submit-etda.libraries.psu.edu/catalog/11736

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University

5. Whitley, Madison Lisbeth. Environmental and Varietal Effects on Niacin and Folate Contents in Raw and Roasted Peanuts.

Degree: MS, Food Science, 2010, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/6273

► Peanuts (Arachis hypogaea L.) are known to be sources of several important B-vitamins, including niacin and folate. Recent research has shown that therapeutic doses of… (more)

▼ Peanuts (Arachis hypogaea L.) are known to be sources of several important B-vitamins, including niacin and folate. Recent research has shown that therapeutic doses of niacin are beneficial for vascular health; therefore, determination of the concentrations found in current varieties in production and potential breeding lines is needed. Folate is a term for a related group of compounds with vitamin activity important in DNA biosynthesis. Adequate levels of folate intake have been found to reduce the risk of a variety of syndromes, most notably fetal neural disorders. Current information about the concentrations and the specific types of folates present may position peanuts as an important source of this nutrient. For the niacin assay, a series of raw and roasted samples from the 2007 and 2008 Uniform Peanut Performance Trials (UPPT) and the 2008 Core of the Core peanut germplasm collection were analyzed to compare levels of niacin across 10 growing locations. Thirty-nine total UPPT Florunner (medium grade size) and NC7 (extra large kernel {ELK} grade size) samples were analyzed using the AOAC non cereal foods method. Thirteen selected samples from the Core of the Core were also analyzed. Niacin concentration (mg/100g) of raw UPPT samples ranged from 8.20 to 25.8 with an average of 16.1 for the 2007 UPPT, 17.7 for the 2008 UPPT, and 16.8 for the Core of the Core samples. The average niacin concentration in raw Florunner and NC7 samples increased from 14.6 and 17.4 in 2007 to 16.4 and 18.9 in 2008, respectively. There was a significant difference between niacin concentration and peanut variety, growing location and year of production. These differences are a result of slowed metabolic processes during dark respiration caused by cooler night temperatures. For the roasted UPPT samples, niacin concentration (mg/100g) ranged from 12.2 to 22.4. There was not a significant difference between raw and roasted samples, due to the stability of niacin to light and heat. For the folate assay, a series of raw and roasted samples from the 2008 UPPT and the 2006 and 2008 Core of the Core were analyzed to compare total folate and individual folate vitamers across varying locations. Twenty-four Core of the Core and 12 UPPT samples were analyzed using a tri-enzyme method of extraction. Total folate content (Î¼g/100g) for Core of the Core samples ranged from 207.7 to 378.3 in 2006 and 116.0 to 257.9 in 2008. The average total folate content (Î¼g/100g) for raw Florunner and NC7 samples was 176.2 and 136.5, respectively, and for the roasted Florunner and NC7 samples was 78.9 and 72.0, respectively. Raw UPPT samples had significantly higher folate contents than roasted UPPT samples, regardless of variety. This is a result of the instability of folate at high temperatures. There was also a significant difference between Florunner and NC7 varieties, but no difference among growing locations. Of the individual folate vitamers, 5-methyl-tetrahydrofolate (THF) and 5-formyl-THF were in the highest amounts regardless of peanut collection,… Advisors/Committee Members: Gabriel Keith Harris, Committee Member (advisor), Timothy H. Sanders, Committee Co-Chair (advisor), Lisa L. Dean, Committee Co-Chair (advisor).

Subjects/Keywords: assay; vitamer; folate; niacin; peanuts

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APA (6^th Edition):

Whitley, M. L. (2010). Environmental and Varietal Effects on Niacin and Folate Contents in Raw and Roasted Peanuts. (Thesis). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/6273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Whitley, Madison Lisbeth. “Environmental and Varietal Effects on Niacin and Folate Contents in Raw and Roasted Peanuts.” 2010. Thesis, North Carolina State University. Accessed March 05, 2021. http://www.lib.ncsu.edu/resolver/1840.16/6273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Whitley, Madison Lisbeth. “Environmental and Varietal Effects on Niacin and Folate Contents in Raw and Roasted Peanuts.” 2010. Web. 05 Mar 2021.

Vancouver:

Whitley ML. Environmental and Varietal Effects on Niacin and Folate Contents in Raw and Roasted Peanuts. [Internet] [Thesis]. North Carolina State University; 2010. [cited 2021 Mar 05]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Whitley ML. Environmental and Varietal Effects on Niacin and Folate Contents in Raw and Roasted Peanuts. [Thesis]. North Carolina State University; 2010. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

6. Heath, Edward M. Effects of nicotinic acid on respiratory exchange ratio and blood-borne substrate levels during exercise.

Degree: PhD, Human Performance, 1990, Oregon State University

URL: http://hdl.handle.net/1957/28330

Subjects/Keywords: Niacin – Physiological effect

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heath, E. M. (1990). Effects of nicotinic acid on respiratory exchange ratio and blood-borne substrate levels during exercise. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/28330

Chicago Manual of Style (16^th Edition):

Heath, Edward M. “Effects of nicotinic acid on respiratory exchange ratio and blood-borne substrate levels during exercise.” 1990. Doctoral Dissertation, Oregon State University. Accessed March 05, 2021. http://hdl.handle.net/1957/28330.

MLA Handbook (7^th Edition):

Heath, Edward M. “Effects of nicotinic acid on respiratory exchange ratio and blood-borne substrate levels during exercise.” 1990. Web. 05 Mar 2021.

Vancouver:

Heath EM. Effects of nicotinic acid on respiratory exchange ratio and blood-borne substrate levels during exercise. [Internet] [Doctoral dissertation]. Oregon State University; 1990. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1957/28330.

Council of Science Editors:

Heath EM. Effects of nicotinic acid on respiratory exchange ratio and blood-borne substrate levels during exercise. [Doctoral Dissertation]. Oregon State University; 1990. Available from: http://hdl.handle.net/1957/28330

7. Hristovska Talija. UTICAJ NIACINA NA LIPIDNI PROFIL I METABOLIČKU ADAPTACIJU KRAVA U RANOJ LAKTACIJI.

Degree: 2017, University of Novi Sad

URL: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija150530211370718.pdf?controlNumber=(BISIS)105028&fileName=150530211370718.pdf&id=10491&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=105028&source=OATD&language=en

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Cilj ove disertacije je da se ispita uticaj aplikacije niacina na metabolizam lipida u peripartalnom periodu, da se utvrdi dali aplikacija niacina utiče na… (more)

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Cilj ove disertacije je da se ispita uticaj aplikacije niacina na metabolizam lipida u peripartalnom periodu, da se utvrdi dali aplikacija niacina utiče na insulinsku rezistenciju, vezu između metaboličkih parametara i lipolize i ketogeneze i uticaj aplikacije niacina na koncetracije NAD i NADP. NAD i NADP predstavljaju adekvatne pokazatelje statusa niacina kod krava u ranoj laktaciji, a njihova vrednost je značajno viša kod krava koje su primale ovaj vitamin. NED i NADP pokazuju pozitivnu korelaciju. Pored ovoga izvedene vrednosti kao što je NAD:NADP indeks i površina ispod krive koju prave ovi vitameri posle teljnja zavise od aplikacije niacina. Aplikacija niacina dovodi do smanjenja koncentracije NEFA, BHB i MDA, a do povećanja koncentracije triglicerida i holesterola u krvi krava. Aplikacija niacina dovodi do porasta koncentracije insulina i glukoze kod krava posle teljenja. Uticaj niacina na insulinsku rezistenciju se mora dvojako posmatrati. Krave koje primaju niacin imaju nižu vrednost indeksa glukoza:insulin, što znači da se po jedinici insulina neutrališe manje glukoze. Ovakvo stanje nastaje jer sa porastom koncentracije insulina opada njegova efikasnost i životinje ulaze u insulinsku rezustenciju. Međutim, RQUICKIBHB indeks insulinske rezistencije je pokazao da su krave koje su primale niacin mnogo osetljivije na insulin, što se može pripisati povećanoj insulinskoj senzitivnosti masnog tkiva. Kod krava koje su primale niacin nađena je niža koncentracija bilirubina i aktivnost AST, ALP i GGT. Nađena je viša koncentracija albumina i viša koncentracija uree i niža koncentracija fosfora. Rezultati pokazuju da aplikacija niacina pozitivno utiče na status hepatocita, a može uticati i na metabolizam proteina u organizmu zbog promena u vrednosti uree. Promena metaboličkih parametara posle teljenja išla je u istom pravcu u oglednoj i kontrolnog grupu, samo se menjao intenzitet promena u funkciji aplikacije niacina. Parcijalna korelacija pokazuje da vitameri niacina mogu objasniti određeni deo korelacije koji postoji između lipolize, ketogeneze i metaboličkim parametrima. Stopa promene veze između 142 metaboličkih parametara sa NEFA i BHB zavisi od stope promene statusa niacina u organizmu krava u ranoj laktaciji. Naknadnim istraživanjima treba odrediti kauzalnu prirodu ovih veza. Krave koje su primale niacina pokazivale su tendenciju povećane proizvodnje mleka do 30. dana laktacije. Ovakav uticaj niacina se izgubio prilikom merenja u 60. danu laktacije. Krave sa boljim statusom niacina (viša vrednost NAD i NADP) pokazuju manji stepen zamašćenja i bolju vitalnost hepatocita, a nađen je i veći dijametar adipocita u potkožnom masnom tkivu, što se može pripisati antilipoliznom efektu niacina.

AB The aim of this dissertation is to examine the effect of niacin on lipid metabolism in perpaturient period, to determine does application of niacin have effects on insulin resistance,…

Advisors/Committee Members: Cincović Marko R., Stojanović Dragica, Jezdimirović Milanka, Toholj Bojan, Belić Branislava.

Subjects/Keywords: SKW Krave; niacin; metabolički status; insulinska rezistencija

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APA (6^th Edition):

Talija, H. (2017). UTICAJ NIACINA NA LIPIDNI PROFIL I METABOLIČKU ADAPTACIJU KRAVA U RANOJ LAKTACIJI. (Thesis). University of Novi Sad. Retrieved from https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija150530211370718.pdf?controlNumber=(BISIS)105028&fileName=150530211370718.pdf&id=10491&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=105028&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Talija, Hristovska. “UTICAJ NIACINA NA LIPIDNI PROFIL I METABOLIČKU ADAPTACIJU KRAVA U RANOJ LAKTACIJI.” 2017. Thesis, University of Novi Sad. Accessed March 05, 2021. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija150530211370718.pdf?controlNumber=(BISIS)105028&fileName=150530211370718.pdf&id=10491&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=105028&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Talija, Hristovska. “UTICAJ NIACINA NA LIPIDNI PROFIL I METABOLIČKU ADAPTACIJU KRAVA U RANOJ LAKTACIJI.” 2017. Web. 05 Mar 2021.

Vancouver:

Talija H. UTICAJ NIACINA NA LIPIDNI PROFIL I METABOLIČKU ADAPTACIJU KRAVA U RANOJ LAKTACIJI. [Internet] [Thesis]. University of Novi Sad; 2017. [cited 2021 Mar 05]. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija150530211370718.pdf?controlNumber=(BISIS)105028&fileName=150530211370718.pdf&id=10491&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=105028&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Talija H. UTICAJ NIACINA NA LIPIDNI PROFIL I METABOLIČKU ADAPTACIJU KRAVA U RANOJ LAKTACIJI. [Thesis]. University of Novi Sad; 2017. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija150530211370718.pdf?controlNumber=(BISIS)105028&fileName=150530211370718.pdf&id=10491&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=105028&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

8. Haynes, Richard. The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial.

Degree: PhD, 2013, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618402

► Niacin has been in clinical use for over 50 years and was the first drug shown in a randomized trial to improve outcomes after MI,… (more)

▼ Niacin has been in clinical use for over 50 years and was the first drug shown in a randomized trial to improve outcomes after MI, but substantial uncertainty remains about its efficacy and safety in the context of current standard medical therapy. This thesis explores the biochemical efficacy, tolerability and safety of extended release (ER) niacin/laropiprant in the large, randomized HPS2-THRIVE trial. Laropiprant is a prostaglandin D₂ receptor (DP1) antagonist which reduces the main adverse effect of niacin, namely “flushing” (an unpleasant cutaneous vasodilation) that makes a large trial of niacin practicable. ER niacin/laropiprant increases high density lipoprotein cholesterol (HDL-C) and apolipoprotein A1, and reduces low density lipoprotein cholesterol (LDL-C), apolipoprotein B, triglycerides and lipoprotein (a), consistent with previous studies of ER niacin. The reasons for stopping ER niacin/laropiprant reflected the known adverse effect profile of ER niacin, although unlike previous trials flushing was not the most frequent reason for stopping. Skin (pruritus and rash), gastrointestinal (nausea, pain and diarrhoea) and diabetes-related (hyperglycaemia) adverse events were the most common reasons for stopping ER niacin/laropiprant during 3.9 years’ follow-up. The analyses presented here identified three major previously unknown hazards of ER niacin. ER niacin/laropiprant increased the risk of statin-related myopathy almost five-fold, and this effect was greater among participants in China than Europe. ER niacin/laropiprant also increased the risk of bleeding (intracranial, gastrointestinal and other sites) and infection. Compared to placebo there was an absolute excess of 3.1% of serious adverse events (excluding cancer and major vascular events [MVEs]) among participants assigned ER niacin/laropiprant. ER niacin/laropiprant did not significantly reduce MVEs. These findings suggest that the use of niacin to reduce vascular risk should now be reconsidered.

Subjects/Keywords: 616.1; Cardiovascular disease; lipids; niacin; safety

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APA (6^th Edition):

Haynes, R. (2013). The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618402

Chicago Manual of Style (16^th Edition):

Haynes, Richard. “The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial.” 2013. Doctoral Dissertation, University of Oxford. Accessed March 05, 2021. http://ora.ox.ac.uk/objects/uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618402.

MLA Handbook (7^th Edition):

Haynes, Richard. “The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial.” 2013. Web. 05 Mar 2021.

Vancouver:

Haynes R. The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial. [Internet] [Doctoral dissertation]. University of Oxford; 2013. [cited 2021 Mar 05]. Available from: http://ora.ox.ac.uk/objects/uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618402.

Council of Science Editors:

Haynes R. The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial. [Doctoral Dissertation]. University of Oxford; 2013. Available from: http://ora.ox.ac.uk/objects/uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618402

Texas Tech University

9. Wang, Hwa Jennifer Chou. Factors influencing the content and the availability of niacin in sorghum.

Degree: Home Economics, 1976, Texas Tech University

URL: http://hdl.handle.net/2346/21937

Subjects/Keywords: Nutrition; Niacin; Sorghum

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, H. J. C. (1976). Factors influencing the content and the availability of niacin in sorghum. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/21937

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Hwa Jennifer Chou. “Factors influencing the content and the availability of niacin in sorghum.” 1976. Thesis, Texas Tech University. Accessed March 05, 2021. http://hdl.handle.net/2346/21937.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Hwa Jennifer Chou. “Factors influencing the content and the availability of niacin in sorghum.” 1976. Web. 05 Mar 2021.

Vancouver:

Wang HJC. Factors influencing the content and the availability of niacin in sorghum. [Internet] [Thesis]. Texas Tech University; 1976. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2346/21937.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang HJC. Factors influencing the content and the availability of niacin in sorghum. [Thesis]. Texas Tech University; 1976. Available from: http://hdl.handle.net/2346/21937

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

10. Phillips, Marjorie Bower. Interrelationship of excess thiamine with niacin in the diet of the albino rat.

Degree: MS, 1962, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:12213

Subjects/Keywords: Vitamin B1; Niacin

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APA (6^th Edition):

Phillips, M. B. (1962). Interrelationship of excess thiamine with niacin in the diet of the albino rat. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:12213

Chicago Manual of Style (16^th Edition):

Phillips, Marjorie Bower. “Interrelationship of excess thiamine with niacin in the diet of the albino rat.” 1962. Masters Thesis, Michigan State University. Accessed March 05, 2021. http://etd.lib.msu.edu/islandora/object/etd:12213.

MLA Handbook (7^th Edition):

Phillips, Marjorie Bower. “Interrelationship of excess thiamine with niacin in the diet of the albino rat.” 1962. Web. 05 Mar 2021.

Vancouver:

Phillips MB. Interrelationship of excess thiamine with niacin in the diet of the albino rat. [Internet] [Masters thesis]. Michigan State University; 1962. [cited 2021 Mar 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:12213.

Council of Science Editors:

Phillips MB. Interrelationship of excess thiamine with niacin in the diet of the albino rat. [Masters Thesis]. Michigan State University; 1962. Available from: http://etd.lib.msu.edu/islandora/object/etd:12213

Iowa State University

11. Schiff, Isaac Joseph. The effects of nicotinamide riboside on postprandial oxidative stress and vascular function.

Degree: 2020, Iowa State University

URL: https://lib.dr.iastate.edu/etd/18220

► High-fat meal (HFM) consumption increases oxidative stress in humans. The metabolic cofactor nicotinamide adenine dinucleotide (NAD+), has been identified as a key regulator of oxidative… (more)

Subjects/Keywords: Niacin; Nicotinamide Riboside; Post Occlusive Reactive Hyperemia

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APA (6^th Edition):

Schiff, I. J. (2020). The effects of nicotinamide riboside on postprandial oxidative stress and vascular function. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/18220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schiff, Isaac Joseph. “The effects of nicotinamide riboside on postprandial oxidative stress and vascular function.” 2020. Thesis, Iowa State University. Accessed March 05, 2021. https://lib.dr.iastate.edu/etd/18220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schiff, Isaac Joseph. “The effects of nicotinamide riboside on postprandial oxidative stress and vascular function.” 2020. Web. 05 Mar 2021.

Vancouver:

Schiff IJ. The effects of nicotinamide riboside on postprandial oxidative stress and vascular function. [Internet] [Thesis]. Iowa State University; 2020. [cited 2021 Mar 05]. Available from: https://lib.dr.iastate.edu/etd/18220.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schiff IJ. The effects of nicotinamide riboside on postprandial oxidative stress and vascular function. [Thesis]. Iowa State University; 2020. Available from: https://lib.dr.iastate.edu/etd/18220

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. 山口, さやか. Depletion of epidermal Langerhans cells in the skin lesions of pellagra patients : ペラグラ患者病変皮膚におけるランゲルハンス細胞の消失.

Degree: 博士(医学), 2016, University of the Ryukyus / 琉球大学

URL: http://hdl.handle.net/20.500.12000/34905

Subjects/Keywords: pellagra; niacin; Langerhans cell; photosensitivity

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APA (6^th Edition):

山口, �. (2016). Depletion of epidermal Langerhans cells in the skin lesions of pellagra patients : ペラグラ患者病変皮膚におけるランゲルハンス細胞の消失. (Thesis). University of the Ryukyus / 琉球大学. Retrieved from http://hdl.handle.net/20.500.12000/34905

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

山口, さやか. “Depletion of epidermal Langerhans cells in the skin lesions of pellagra patients : ペラグラ患者病変皮膚におけるランゲルハンス細胞の消失.” 2016. Thesis, University of the Ryukyus / 琉球大学. Accessed March 05, 2021. http://hdl.handle.net/20.500.12000/34905.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

山口, さやか. “Depletion of epidermal Langerhans cells in the skin lesions of pellagra patients : ペラグラ患者病変皮膚におけるランゲルハンス細胞の消失.” 2016. Web. 05 Mar 2021.

Vancouver:

山口 �. Depletion of epidermal Langerhans cells in the skin lesions of pellagra patients : ペラグラ患者病変皮膚におけるランゲルハンス細胞の消失. [Internet] [Thesis]. University of the Ryukyus / 琉球大学; 2016. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/20.500.12000/34905.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

山口 �. Depletion of epidermal Langerhans cells in the skin lesions of pellagra patients : ペラグラ患者病変皮膚におけるランゲルハンス細胞の消失. [Thesis]. University of the Ryukyus / 琉球大学; 2016. Available from: http://hdl.handle.net/20.500.12000/34905

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Jain, Gaurav. To study the effects & withdrawal of atrovastain, fenofibrate and niacin on lipid and lipoprotein profile in patients of dyslipidemia; -.

Degree: Medicine, 2004, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/12505

None

Bibliography p.85-93 Appendix p. 94-97

Advisors/Committee Members: Arora, R C, Agarwal, Navneet.

Subjects/Keywords: atovastain; dyslipidemia; fenofibrate; lipoprotein; niacin

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APA (6^th Edition):

Jain, G. (2004). To study the effects & withdrawal of atrovastain, fenofibrate and niacin on lipid and lipoprotein profile in patients of dyslipidemia; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/12505

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jain, Gaurav. “To study the effects & withdrawal of atrovastain, fenofibrate and niacin on lipid and lipoprotein profile in patients of dyslipidemia; -.” 2004. Thesis, Bundelkhand University. Accessed March 05, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/12505.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jain, Gaurav. “To study the effects & withdrawal of atrovastain, fenofibrate and niacin on lipid and lipoprotein profile in patients of dyslipidemia; -.” 2004. Web. 05 Mar 2021.

Vancouver:

Jain G. To study the effects & withdrawal of atrovastain, fenofibrate and niacin on lipid and lipoprotein profile in patients of dyslipidemia; -. [Internet] [Thesis]. Bundelkhand University; 2004. [cited 2021 Mar 05]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/12505.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jain G. To study the effects & withdrawal of atrovastain, fenofibrate and niacin on lipid and lipoprotein profile in patients of dyslipidemia; -. [Thesis]. Bundelkhand University; 2004. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/12505

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

14. Chamberlain, Jason L. The effect of nicotinic acid supplementation during late-gestation on lipolysis and feed intake during the transition period.

Degree: MS, Animal Science, 2006, Oregon State University

URL: http://hdl.handle.net/1957/2269

► An experiment was conducted with 27 multiparous Holstein and 27 multiparous Jersey cows to determine if nicotinic acid (NA) supplementation during the prepartum phase of… (more)

▼ An experiment was conducted with 27 multiparous Holstein and 27 multiparous Jersey cows to determine if nicotinic acid (NA) supplementation during the prepartum phase of the transition period decreases lipolysis and improves dry matter intake and to determine if Holstein and Jersey cows respond similarly to NA supplementation. Cows were blocked by expected calving date and assigned at random to one of three prepartum dietary treatments which were 0, 49, and 98 mg of NA/kg of body weight (BW). Cows were group housed in freestalls and fed individually via Calan® gates from 30 d prepartum to 21 d postpartum. Cows were offered a dry cow total mixed ration twice daily and NA was hand mixed in the morning feeding. Following parturition all cows received the same lactation total mixed ration. Data were analyzed as repeated measures using the MIXED procedure of SAS. Dry matter intake -3 wk prepartum was used as a covariate for analysis of prepartum dry matter intake. Prepartum and postpartum BW and body condition score (BCS) were similar for NA treatments. Body weight was greater for Holsteins compared to Jerseys; however BCS between breeds did not differ. Prepartum DMI was similar for NA treatments, but cows supplemented with 49 mg NA/kg BW had greater DMI following parturition. Prepartum DMI depression was greater for Holsteins compared with Jerseys, 32 and 14%, respectively. Prepartum NA treatment had no effect on prepartum or postpartum nonesterfied fatty acids (NEFA), β-hydroxybutyrate, and glucose. The magnitude of increase of NEFA as parturition approached was greater for Holsteins compared with Jerseys. Further, plasma NEFA of Jersey cows were lower than Holstein cows during the postpartum period (613 vs 862 µEq/L for Jerseys and Holsteins). Milk production differed between NA treatments, with increased production from cows supplemented with 49 mg NA/kg body BW compared to other treatments. Milk composition was not affected by the supplementation of NA. In summary, supplemental NA during the last 3 wk of gestation did not affect DMI or plasma metabolites during the transition period. Lipid metabolism and prepartum feed intake depression does differ for the two major breeds of dairy cattle. Key Words: dairy breed, transition cow, nicotinic acid Advisors/Committee Members: French, Patrick D. (advisor), Thompson, Jim (committee member).

Subjects/Keywords: Dairy breed; Niacin – Physiological effect

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chamberlain, J. L. (2006). The effect of nicotinic acid supplementation during late-gestation on lipolysis and feed intake during the transition period. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/2269

Chicago Manual of Style (16^th Edition):

Chamberlain, Jason L. “The effect of nicotinic acid supplementation during late-gestation on lipolysis and feed intake during the transition period.” 2006. Masters Thesis, Oregon State University. Accessed March 05, 2021. http://hdl.handle.net/1957/2269.

MLA Handbook (7^th Edition):

Chamberlain, Jason L. “The effect of nicotinic acid supplementation during late-gestation on lipolysis and feed intake during the transition period.” 2006. Web. 05 Mar 2021.

Vancouver:

Chamberlain JL. The effect of nicotinic acid supplementation during late-gestation on lipolysis and feed intake during the transition period. [Internet] [Masters thesis]. Oregon State University; 2006. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1957/2269.

Council of Science Editors:

Chamberlain JL. The effect of nicotinic acid supplementation during late-gestation on lipolysis and feed intake during the transition period. [Masters Thesis]. Oregon State University; 2006. Available from: http://hdl.handle.net/1957/2269

University of Arizona

15. Rungruang, Sunthorn. Evaluation of Dietary Niacin and Supplemental Cooling for Alleviation of Heat Stress in Lactating Dairy Cows .

Degree: 2012, University of Arizona

URL: http://hdl.handle.net/10150/265340

► Four studies were conducted to evaluate the effects of supplemental cooling and niacin on heat stress (HS) responses in vivo and in vitro in lactating… (more)

▼ Four studies were conducted to evaluate the effects of supplemental cooling and niacin on heat stress (HS) responses in vivo and in vitro in lactating dairy cows. For experiment one, lactating dairy cows were fed four levels of dietary niacin, NIASHURE® (0,4,8,12 g/d) for 21 d. Heat stress decreased niacin levels in whole blood, red blood cells and plasma as compared to thermoneutral. Water intake, plasma and milk niacin concentrations increased linearly with increasing dietary niacin in HS cattle. In thermoneutral, but not HS cows, niacin increased skin temperature compared to controls suggesting niacin increased skin blood flow and sensible heat loss. In experiment 2, lactating cows were used to evaluate the impact of feed-line soaking (FLS) combined with niacin supplementation. In evaporative cooled barns, FLS reduced body temperatures; however the addition of niacin did not improve heat status of these cows. For experiment 3, 200 lactating dairy cows were used to determine the effects of conductively cooled bedding (CC) compared to feed-line soaking with fans (FLSF). Conductively cooled bedding can reduce skin and vaginal temperatures in cows after nighttime rest. However, FLSF were more effective in decreasing body temperature, as cows had lower heat parameter indices, higher milk yield and longer rest time. For experiment 4, three cell types were used to evaluate niacin in vitro. Niacin induced heat shock proteins (HSP) that protected cells during HS in transformed bovine mammary epithelial cells but not in primary bovine mammary epithelial cells (BMEC) or bovine endometrial cells (BEND). Effect of niacin on HSP may depend on enzymes involved in DNA-binding activity of heat shock factor 1. These results suggest that niacin may be involved in whole body metabolism during heat stress and is cell dependent. We did not find dietary niacin to be commercially efficacious in treating HS in cows. Further research is warranted to improve efficacy of CC and FLSF under high temperature humidity index conditions. Advisors/Committee Members: Collier, Robert J (advisor), Smith, John F. (committeemember), Renquist, Benjamin J. (committeemember), Santos, Jose E. P. (committeemember), Bilby, Todd R. (committeemember), Collier, Robert J. (committeemember).

Subjects/Keywords: Heat stress; Niacin; Animal Sciences; Cooling; Dairy cows

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APA (6^th Edition):

Rungruang, S. (2012). Evaluation of Dietary Niacin and Supplemental Cooling for Alleviation of Heat Stress in Lactating Dairy Cows . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/265340

Chicago Manual of Style (16^th Edition):

Rungruang, Sunthorn. “Evaluation of Dietary Niacin and Supplemental Cooling for Alleviation of Heat Stress in Lactating Dairy Cows .” 2012. Doctoral Dissertation, University of Arizona. Accessed March 05, 2021. http://hdl.handle.net/10150/265340.

MLA Handbook (7^th Edition):

Rungruang, Sunthorn. “Evaluation of Dietary Niacin and Supplemental Cooling for Alleviation of Heat Stress in Lactating Dairy Cows .” 2012. Web. 05 Mar 2021.

Vancouver:

Rungruang S. Evaluation of Dietary Niacin and Supplemental Cooling for Alleviation of Heat Stress in Lactating Dairy Cows . [Internet] [Doctoral dissertation]. University of Arizona; 2012. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10150/265340.

Council of Science Editors:

Rungruang S. Evaluation of Dietary Niacin and Supplemental Cooling for Alleviation of Heat Stress in Lactating Dairy Cows . [Doctoral Dissertation]. University of Arizona; 2012. Available from: http://hdl.handle.net/10150/265340

Michigan State University

16. Klooster, Beverly Jane, 1937-. The influence of dietary fat on the response of the weanling albino rat to excessive intake of thiamine and niacin.

Degree: MS, 1961, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:11905

Subjects/Keywords: Niacin; Vitamin B1; Hypervitaminosis

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APA (6^th Edition):

Klooster, Beverly Jane, 1. (1961). The influence of dietary fat on the response of the weanling albino rat to excessive intake of thiamine and niacin. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:11905

Chicago Manual of Style (16^th Edition):

Klooster, Beverly Jane, 1937-. “The influence of dietary fat on the response of the weanling albino rat to excessive intake of thiamine and niacin.” 1961. Masters Thesis, Michigan State University. Accessed March 05, 2021. http://etd.lib.msu.edu/islandora/object/etd:11905.

MLA Handbook (7^th Edition):

Klooster, Beverly Jane, 1937-. “The influence of dietary fat on the response of the weanling albino rat to excessive intake of thiamine and niacin.” 1961. Web. 05 Mar 2021.

Vancouver:

Klooster, Beverly Jane 1. The influence of dietary fat on the response of the weanling albino rat to excessive intake of thiamine and niacin. [Internet] [Masters thesis]. Michigan State University; 1961. [cited 2021 Mar 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:11905.

Council of Science Editors:

Klooster, Beverly Jane 1. The influence of dietary fat on the response of the weanling albino rat to excessive intake of thiamine and niacin. [Masters Thesis]. Michigan State University; 1961. Available from: http://etd.lib.msu.edu/islandora/object/etd:11905

Uppsala University

17. Amin, Benai. Lipidförändrande effekten av niacin.

Degree: Pharmaceutical Biosciences, 2020, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426878

► Niacin som upptäcktes för 70 år sedan är en substans som än i dag studeras mycket kring. Men fortfarande är man inte överens om… (more)

▼ Niacin som upptäcktes för 70 år sedan är en substans som än i dag studeras mycket kring. Men fortfarande är man inte överens om niacin verkligen har en signifikant effekt på kardiovaskulära sjukdomar. Verkningsmekanismen för niacin är ännu oklar, men forskning pekar på att hämmad syntes av triglycerider resulterar i en minskad LDL-koncentration. HDL-ökningen tros bero på en hämmad nedbrytning av HDL-partiklar, och därmed blir en större mängd HDL kvar i blodet. Nuvarande lipidbehandling består först och främst av en balanserad kost och ökad fysisk aktivitet. Vid otillräcklig effekt sätts läkemedelsbehandling in, som består av statiner, resiner, fibrater och hämmare av kolesterolupptag i tarmen. Syftet med detta arbete är att studera om niacin, både som monoterapi och i kombination med andra lipidsänkande preparat, har en påverkan på blodlipidvärdena HDL, LDL och triglycerider, hos människor. Genom systematisk litteratursökning har artiklar samlats in för att kunna sammanställa resultaten. Alla tio studierna som inkluderades kom fram till att niacin, antingen i kombination med andra lipidsänkande preparat eller som monoterapi, har en signifikant effekt på lipoproteinerna. Resultaten visade en LDL-sänkning upp till 58,5% (i kombination), den högsta HDL-ökning var 50% (monoterapi) och högsta triglycerid-sänkningen var 51,7% (i kombination). Dock är niacins effekt på LDL och triglycerider likartad eller sämre än dagens lipidsänkande preparat. Niacin har däremot en större effekt när det kommer till HDL-ökningen. Därför bör det göras flera och större studier gällande niacins effekt på HDL. Om studierna visar positiva resultat bör det övervägas för användning hos patienter med låg HDL. Dock orsakar biverkningarna en sämre följsamhet, och eventuella analoger till niacin bör utvecklas, detta för att inte gå miste om en eventuellt potent HDL-ökande behandling. Slutsatsen för detta arbete är att i människa har niacin en signifikant effekt på lipoproteinerna LDL och HDL samt lipiden triglycerider. Behandling med niacin leder till en sänkning av LDL och triglycerider samt en markant ökning av HDL.

Subjects/Keywords: Niacin; LDL; HDL; triglycerider; lipider; Pharmacology and Toxicology; Farmakologi och toxikologi

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APA (6^th Edition):

Amin, B. (2020). Lipidförändrande effekten av niacin. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426878

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Amin, Benai. “Lipidförändrande effekten av niacin.” 2020. Thesis, Uppsala University. Accessed March 05, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426878.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Amin, Benai. “Lipidförändrande effekten av niacin.” 2020. Web. 05 Mar 2021.

Vancouver:

Amin B. Lipidförändrande effekten av niacin. [Internet] [Thesis]. Uppsala University; 2020. [cited 2021 Mar 05]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426878.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Amin B. Lipidförändrande effekten av niacin. [Thesis]. Uppsala University; 2020. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-426878

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

18. Makhani, Neelam. Niacin (pharmacologic dose levels)-induced hyperhomocysteinemia in rats.

Degree: MS, Department of Agricultural, Food, and Nutritional Science, 1998, University of Alberta

URL: https://era.library.ualberta.ca/files/bz60cz13n

Subjects/Keywords: Methionine.; Niacin – Therapeutic use.; Niacin – Physiological effect.; Antilipemic agents.; Cysteine proteinases.

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APA (6^th Edition):

Makhani, N. (1998). Niacin (pharmacologic dose levels)-induced hyperhomocysteinemia in rats. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/bz60cz13n

Chicago Manual of Style (16^th Edition):

Makhani, Neelam. “Niacin (pharmacologic dose levels)-induced hyperhomocysteinemia in rats.” 1998. Masters Thesis, University of Alberta. Accessed March 05, 2021. https://era.library.ualberta.ca/files/bz60cz13n.

MLA Handbook (7^th Edition):

Makhani, Neelam. “Niacin (pharmacologic dose levels)-induced hyperhomocysteinemia in rats.” 1998. Web. 05 Mar 2021.

Vancouver:

Makhani N. Niacin (pharmacologic dose levels)-induced hyperhomocysteinemia in rats. [Internet] [Masters thesis]. University of Alberta; 1998. [cited 2021 Mar 05]. Available from: https://era.library.ualberta.ca/files/bz60cz13n.

Council of Science Editors:

Makhani N. Niacin (pharmacologic dose levels)-induced hyperhomocysteinemia in rats. [Masters Thesis]. University of Alberta; 1998. Available from: https://era.library.ualberta.ca/files/bz60cz13n

19. Souza, Bianca Rodrigues de. Quantificação das vitaminas do complexo B (B1, B2) e vitâmeros das vitaminas B3 e B6 em amostras de pólen apícola desidratado provenientes da Região Sul do Brasil.

Degree: Mestrado, Bromatologia, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/9/9131/tde-27052015-141055/ ;

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Entende-se por pólen apícola o resultado da aglutinação do pólen das flores, efetuado pelas abelhas operárias, mediante néctar e substâncias salivares, o qual é recolhido… (more)

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Entende-se por pólen apícola o resultado da aglutinação do pólen das flores, efetuado pelas abelhas operárias, mediante néctar e substâncias salivares, o qual é recolhido no ingresso da colmeia. A literatura descreve que esse alimento contém proteínas, carboidratos, lipídeos, vitaminas e minerais. De acordo com estudo prévio, amostras de pólen apícola in natura e desidratado, da cidade de Pariquera-Açu (São Paulo), apresentaram teores significativos de vitamina B1(tiamina) e B2 (riboflavina), além da presença dos vitâmeros da vitamina B3 (ácido nicotínico e nicotinamida) e B6 (piridoxal, piridoxol e piridoxamina) em sua composição o que foi associado à flora local explorada pelas abelhas. A região Sul do Brasil possui clima, relevo e vegetação diferenciados de outras regiões, necessitando-se assim da verificação do potencial vitamínico deste produto local. Destaca-se, ainda, o fato de que nesta região encontra-se um dos dois maiores produtores nacionais de pólen apícola (estado de Santa Catarina). O presente trabalho teve como objetivo principal quantificar os teores das vitaminas do complexo B: vitaminas B1 e B2, assim como os vitâmeros das vitaminas B3 e B6. Foram coletados 28 lotes de pólen apícola desidratado de diferentes localidades da região Sul durante o período de agosto de 2011 a dezembro de 2012 que posteriormente foram armazenados, a -18 °C até o momento das análises. As vitaminas do complexo B foram analisadas por cromatografia liquida de alta eficiência (CLAE) na matriz pólen apícola desidratado e os resultados foram expressos em base seca. Entre as amostras analisadas foram verificados teores de vitamina B1 variando entre 0,46 e 1,83 mg / 100 g de pólen apícola; vitamina B2 de 0,40 à 1,86 mg / 100 g e quanto à vitamina B6 apenas os vitâmeros piridoxal e piridoxamina puderam ser quantificados em todos os lotes analisados. O piridoxal teve variação entre as amostras de 0,42 à 6,70 mg / 100 g e a piridoxamina de 0,26 à 0,95 mg / 100g. Em relação à vitamina B3, o vitâmero ácido nicotínico apresentou-se nos diferentes lotes variando de 0,68 à 3,93 mg / 100 g e a nicotinamida de 0,27 à 5,54 mg / 100 g de produto. Tomando-se como porção sugerida para consumo diário 25 g de pólen apícola, verificou-se que num total de 28 amostras, 15 foram consideradas fontes e 2 como ricas em tiamina; 19 lotes foram fontes e 3 ricos em riboflavina, e; 2 lotes foram fontes e 26 ricos em piridoxina segundo à Ingestão Diária Recomendada (IDR) para adultos como disponibilizado na Resolução de Diretoria Colegiada (RDC) nº. 269, de 22 de setembro de 2005.

Bee pollen is understood to be the result of agglutination of pollen from flowers, made by worker bees, and nectar through salivary substances, which is collected at the hive entrance. The literature describes that this product contains proteins, carbohydrates, lipids, vitamins, minerals. Previous study with fresh and dehydrated bee pollen, from the city of Pariquera-Açu (São Paulo) showed significant levels of vitamin B1 (thiamine), B2 (riboflavin), presence of B3 (nicotinic…

Advisors/Committee Members: Almeida-Muradian, Ligia Bicudo de.

Subjects/Keywords: Bee pollen; Niacin; Niacina; Piridoxina; Pólen apícola; Pyridoxine; Riboflavin; Riboflavina; Thiamine; Tiamina; Vitaminas; Vitamins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, B. R. d. (2014). Quantificação das vitaminas do complexo B (B1, B2) e vitâmeros das vitaminas B3 e B6 em amostras de pólen apícola desidratado provenientes da Região Sul do Brasil. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/9/9131/tde-27052015-141055/ ;

Chicago Manual of Style (16^th Edition):

Souza, Bianca Rodrigues de. “Quantificação das vitaminas do complexo B (B1, B2) e vitâmeros das vitaminas B3 e B6 em amostras de pólen apícola desidratado provenientes da Região Sul do Brasil.” 2014. Masters Thesis, University of São Paulo. Accessed March 05, 2021. http://www.teses.usp.br/teses/disponiveis/9/9131/tde-27052015-141055/ ;.

MLA Handbook (7^th Edition):

Souza, Bianca Rodrigues de. “Quantificação das vitaminas do complexo B (B1, B2) e vitâmeros das vitaminas B3 e B6 em amostras de pólen apícola desidratado provenientes da Região Sul do Brasil.” 2014. Web. 05 Mar 2021.

Vancouver:

Souza BRd. Quantificação das vitaminas do complexo B (B1, B2) e vitâmeros das vitaminas B3 e B6 em amostras de pólen apícola desidratado provenientes da Região Sul do Brasil. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2021 Mar 05]. Available from: http://www.teses.usp.br/teses/disponiveis/9/9131/tde-27052015-141055/ ;.

Council of Science Editors:

Souza BRd. Quantificação das vitaminas do complexo B (B1, B2) e vitâmeros das vitaminas B3 e B6 em amostras de pólen apícola desidratado provenientes da Região Sul do Brasil. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/9/9131/tde-27052015-141055/ ;

East Carolina University

20. Rezq, Samar. Central GPR109A Mediates Neuronal Oxidative Stress and Pressor Response in Conscious Rats.

Degree: PhD, PHD-Pharmacology - Toxicology, 2016, East Carolina University

URL: http://hdl.handle.net/10342/5389

► The primary goal of this study was to characterize the role of GPR109A in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and… (more)

▼ The primary goal of this study was to characterize the role of GPR109A in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and to elucidate the mechanisms involved in the hypertensive response elicited by central GPR109A activation. The central hypothesis of this study was "central GPR109A activation causes neuronal oxidative stress and pressor response via local glutamate/prostaglandins release". The data provide the first evidence for GPR109A expression in the RVLM, the major cardiovascular regulatory nucleus of the brainstem, and in pheochromocytoma cell line (PC12 cells), used as surrogates of the RVLM neurons. GPR109A co-localization was evident in tyrosine hydroxylase (TH)-expressing neurons and in PC12 cells. The anti-hyperlipidemic drug, nicotinic acid (NA) a known GPR109A agonist that activate the receptor and Ca2+-dependently release prostaglandins (PGs), was used in the study. Our findings demonstrated that intra-RVLM activation of GPR109A receptors with NA produced a robust dose-dependent glutamate-like elevation in sympathetic tone and BP in normotensive conscious male Sprague Dawley (SD) rats. The pressor response was abolished by prior blockade of the NMDA glutamate receptor (NMDAR) using 2-amino-5-phosphonopentanoic acid (AP5) or the prostanoid EP3 receptor (EP3R) using N-[(5-Bromo-2-methoxyphenyl) sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide (L-798106). Further, the NA pressor response was exacerbated by a prior application of the glutamate uptake inhibitor, L-trans-Pyrrolidine-2,4-dicarboxylic acid (PDC). Ex vivo studies revealed that intra-RVLM GPR109A activation (NA; 20[mu]g) increased local prostaglandin E2 (PGE2) levels, enhanced RVLM ERK1/2 and nNOS phosphorylation and increased c-Fos immunoreactivity. Further, NA induced oxidative stress in the RVLM of NA-treated rats (increased ROS levels and NADPH oxidase activity and decreased catalase activity). Prior EP3R blockade (L-798106) abrogated the biochemical and the pressor response caused by intra-RVLM NA. NMDAR (AP5) or EP3R blockade similarly abolished NA-mediated pressor response, indicating the involvement of both glutamate and PGE2 in this effect. Selective inhibition of RVLM nNOS (N[omega]-propyl-L-arginine; NPLA) abolished the intra-RVLM NA-evoked pressor response. Further, NPLA abrogated the GPR109A-mediated increases in RVLM nNOS phosphorylation and c-Fos and ROS levels. Our in vitro (PC12) studies supported and extended the in-vivo findings as NA increased Ca2+, PGE2, L-glutamate and NO levels as well as ROS levels in cultured PC12 cells. The increase in L-glutamate level is likely mediated by PGE2/EP3R because L-798106 attenuated NA or PGE2-evoked L-glutamate release. The above-mentioned effects are mediated via GPR109A because the use of the inactive isomer, IsoNA failed to produce any hemodynamic or biochemical changes. Further, NA failed to increase Ca2+ or L-glutamate levels in PC12 cells following siRNA-evoked GPR109A knockdown. Collectively, these studies provide insight into identifying… Advisors/Committee Members: Abdel-Rahman, Abdel A. (advisor).

Subjects/Keywords: RVLM; GPR109A; Niacin; L-glutamate; PGE2; Nicotinic Acids; Consciousness; Oxidative Stress; Rats; Vasoconstrictor Agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rezq, S. (2016). Central GPR109A Mediates Neuronal Oxidative Stress and Pressor Response in Conscious Rats. (Doctoral Dissertation). East Carolina University. Retrieved from http://hdl.handle.net/10342/5389

Chicago Manual of Style (16^th Edition):

Rezq, Samar. “Central GPR109A Mediates Neuronal Oxidative Stress and Pressor Response in Conscious Rats.” 2016. Doctoral Dissertation, East Carolina University. Accessed March 05, 2021. http://hdl.handle.net/10342/5389.

MLA Handbook (7^th Edition):

Rezq, Samar. “Central GPR109A Mediates Neuronal Oxidative Stress and Pressor Response in Conscious Rats.” 2016. Web. 05 Mar 2021.

Vancouver:

Rezq S. Central GPR109A Mediates Neuronal Oxidative Stress and Pressor Response in Conscious Rats. [Internet] [Doctoral dissertation]. East Carolina University; 2016. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10342/5389.

Council of Science Editors:

Rezq S. Central GPR109A Mediates Neuronal Oxidative Stress and Pressor Response in Conscious Rats. [Doctoral Dissertation]. East Carolina University; 2016. Available from: http://hdl.handle.net/10342/5389

Texas Tech University

21. Shu, Gloria Shu-Yi Chang. Niacin retention and consumer acceptability of chicken tetrazzini prepared for cook/chill and cook/freeze foodservice systems.

Degree: Home Economics, 1978, Texas Tech University

URL: http://hdl.handle.net/2346/10862

Subjects/Keywords: Frozen foods; Niacin; Food – Sensory evaluation

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APA (6^th Edition):

Shu, G. S. C. (1978). Niacin retention and consumer acceptability of chicken tetrazzini prepared for cook/chill and cook/freeze foodservice systems. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/10862

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shu, Gloria Shu-Yi Chang. “Niacin retention and consumer acceptability of chicken tetrazzini prepared for cook/chill and cook/freeze foodservice systems.” 1978. Thesis, Texas Tech University. Accessed March 05, 2021. http://hdl.handle.net/2346/10862.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shu, Gloria Shu-Yi Chang. “Niacin retention and consumer acceptability of chicken tetrazzini prepared for cook/chill and cook/freeze foodservice systems.” 1978. Web. 05 Mar 2021.

Vancouver:

Shu GSC. Niacin retention and consumer acceptability of chicken tetrazzini prepared for cook/chill and cook/freeze foodservice systems. [Internet] [Thesis]. Texas Tech University; 1978. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2346/10862.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shu GSC. Niacin retention and consumer acceptability of chicken tetrazzini prepared for cook/chill and cook/freeze foodservice systems. [Thesis]. Texas Tech University; 1978. Available from: http://hdl.handle.net/2346/10862

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

22. Siebeling, Ronald Jon, 1937-. The effects of niacin deficiency on phagocytosis and susceptibility to infection .

Degree: 1962, University of Arizona

URL: http://hdl.handle.net/10150/319413

Subjects/Keywords: Disease susceptibility.; Niacin.; Deficiency diseases.; Phagocytosis.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Siebeling, Ronald Jon, 1. (1962). The effects of niacin deficiency on phagocytosis and susceptibility to infection . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/319413

Chicago Manual of Style (16^th Edition):

Siebeling, Ronald Jon, 1937-. “The effects of niacin deficiency on phagocytosis and susceptibility to infection .” 1962. Masters Thesis, University of Arizona. Accessed March 05, 2021. http://hdl.handle.net/10150/319413.

MLA Handbook (7^th Edition):

Siebeling, Ronald Jon, 1937-. “The effects of niacin deficiency on phagocytosis and susceptibility to infection .” 1962. Web. 05 Mar 2021.

Vancouver:

Siebeling, Ronald Jon 1. The effects of niacin deficiency on phagocytosis and susceptibility to infection . [Internet] [Masters thesis]. University of Arizona; 1962. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10150/319413.

Council of Science Editors:

Siebeling, Ronald Jon 1. The effects of niacin deficiency on phagocytosis and susceptibility to infection . [Masters Thesis]. University of Arizona; 1962. Available from: http://hdl.handle.net/10150/319413

University of Arizona

23. Benavente, Claudia. Cellular NAD Status as a Regulator of Skin Photodamage .

Degree: 2007, University of Arizona

URL: http://hdl.handle.net/10150/194309

► The maintenance and regulation of cellular NAD(P)(H) content and its influence on cell function involves in many metabolic pathways which are poorly understood. Niacin deficiency… (more)

▼ The maintenance and regulation of cellular NAD(P)(H) content and its influence on cell function involves in many metabolic pathways which are poorly understood. Niacin deficiency in humans, which leads to low NAD status, causes sun sensitivity in skin, indicative of DNA repair deficiencies. Animal models of niacin deficiency demonstrate genomic instability and increased cancer development in sensitive tissues including skin. Therefore, we have developed a cell culture model that allows assessment of pathways regulated by NAD(P) content as a way to identify NAD-dependent signaling events that may be critical in early skin carcinogenesis. Using our model, we showed that niacin restriction, and consequent NAD depletion, reversibly alters NAD(P)(H) pools, increases apoptosis, induces G2/M cell cycle arrest, and decreases DNA stability. These alterations are affected by increased expression and activity of NOX leading to an accumulation of ROS, which may provide a survival mechanism as has been shown in cancer cells. Our data also support the hypothesis that glutamine is a likely alternative energy source during niacin deficiency. Here, we also identified the expression of all seven NAD-dependent deacetylase (SIRT) family members in skin cells. We showed that in response to photodamage, the expression of several SIRTs is altered in keratinocytes. Furthermore, we showed that SIRTs responses to photodamage differ between normal and immortalized keratinocytes, which may be indicative of alterations potentially important in skin carcinogenesis. In addition, we have shown that NAD-depleted HaCaT keratinocytes are more sensitive to photodamage. We observed that both poly(ADP-ribose) polymerases (PARPs) and SIRTs are inhibited by the unavailability of their substrate, NAD+, leading to unrepaired DNA damage upon photodamage and subsequent increase in cell death. Our data demonstrate that both SIRTs and PARPs are critical following DNA damage and identify which SIRTs are essential. Finally, we identified for the first time the expression of the nicotinic acid receptor in human skin keratinocytes, mainly in the differentiating keratinocytes of the stratum corneum in the epidermis. This study identifies new roles for niacin as a potential skin cancer prevention agent and demonstrates that niacin status is a critical resistance factor for UV damaged skin cells. Advisors/Committee Members: Jacobson, Elaine L (advisor), Bowden, G. Tim (committeemember), Briehl, Margaret (committeemember), Lau, Serrine (committeemember), Romagnolo, Donato (committeemember).

Subjects/Keywords: niacin; NAD; PARP; SIRT; skin cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Benavente, C. (2007). Cellular NAD Status as a Regulator of Skin Photodamage . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/194309

Chicago Manual of Style (16^th Edition):

Benavente, Claudia. “Cellular NAD Status as a Regulator of Skin Photodamage .” 2007. Doctoral Dissertation, University of Arizona. Accessed March 05, 2021. http://hdl.handle.net/10150/194309.

MLA Handbook (7^th Edition):

Benavente, Claudia. “Cellular NAD Status as a Regulator of Skin Photodamage .” 2007. Web. 05 Mar 2021.

Vancouver:

Benavente C. Cellular NAD Status as a Regulator of Skin Photodamage . [Internet] [Doctoral dissertation]. University of Arizona; 2007. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10150/194309.

Council of Science Editors:

Benavente C. Cellular NAD Status as a Regulator of Skin Photodamage . [Doctoral Dissertation]. University of Arizona; 2007. Available from: http://hdl.handle.net/10150/194309

University of Toledo

24. Gebremichael, Ermias. Pharmaceutical Eutectics: Characterization and Evaluation of Tolbutamide and Haloperidol using Thermal Analytical and Complementary Techniques.

Degree: MSin Pharmaceutical Sciences, College of Pharmacy, 2010, University of Toledo

URL: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271439418

► A considerable number of drugs on the market have been shown to have low bioavailability and solubility due to poor dissolution in the gastrointestinal tract.… (more)

Subjects/Keywords: Pharmaceuticals; Eutectics; Haloperidol; Aminophylline; Tolbutamide; Niacin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gebremichael, E. (2010). Pharmaceutical Eutectics: Characterization and Evaluation of Tolbutamide and Haloperidol using Thermal Analytical and Complementary Techniques. (Masters Thesis). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271439418

Chicago Manual of Style (16^th Edition):

Gebremichael, Ermias. “Pharmaceutical Eutectics: Characterization and Evaluation of Tolbutamide and Haloperidol using Thermal Analytical and Complementary Techniques.” 2010. Masters Thesis, University of Toledo. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271439418.

MLA Handbook (7^th Edition):

Gebremichael, Ermias. “Pharmaceutical Eutectics: Characterization and Evaluation of Tolbutamide and Haloperidol using Thermal Analytical and Complementary Techniques.” 2010. Web. 05 Mar 2021.

Vancouver:

Gebremichael E. Pharmaceutical Eutectics: Characterization and Evaluation of Tolbutamide and Haloperidol using Thermal Analytical and Complementary Techniques. [Internet] [Masters thesis]. University of Toledo; 2010. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271439418.

Council of Science Editors:

Gebremichael E. Pharmaceutical Eutectics: Characterization and Evaluation of Tolbutamide and Haloperidol using Thermal Analytical and Complementary Techniques. [Masters Thesis]. University of Toledo; 2010. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271439418

25. Jeba Ananthi,K. Studies on the effect of slf and sglf on water stressed plants;.

Degree: 2014, Manonmaniam Sundaranar University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/15719

►

Seaweeds are excellent source of vitamins A, B1, B12, C, D and E, riboflavin, niacin, pantothanic acid and folic acid as well as minerals such… (more)

Subjects/Keywords: folic acid; niacin; pantothanic acid; riboflavin; Seaweeds; sglf; slf; vitamins A, B1, B12, C, D and E,; water stressed plants

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ananthi,K, J. (2014). Studies on the effect of slf and sglf on water stressed plants;. (Thesis). Manonmaniam Sundaranar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/15719

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ananthi,K, Jeba. “Studies on the effect of slf and sglf on water stressed plants;.” 2014. Thesis, Manonmaniam Sundaranar University. Accessed March 05, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/15719.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ananthi,K, Jeba. “Studies on the effect of slf and sglf on water stressed plants;.” 2014. Web. 05 Mar 2021.

Vancouver:

Ananthi,K J. Studies on the effect of slf and sglf on water stressed plants;. [Internet] [Thesis]. Manonmaniam Sundaranar University; 2014. [cited 2021 Mar 05]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15719.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ananthi,K J. Studies on the effect of slf and sglf on water stressed plants;. [Thesis]. Manonmaniam Sundaranar University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/15719

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

26. Chamas, Liliane. The nicotinic acid receptor in human adipose tissue.

Degree: PhD, 2013, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:82650691-be95-4cf7-a3cd-e0821062f49d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604411

► Nicotinic acid (NA) has been clinically used for over 50 years to regulate lipid plasma levels. It is the only drug in current clinical use… (more)

▼ Nicotinic acid (NA) has been clinically used for over 50 years to regulate lipid plasma levels. It is the only drug in current clinical use that significantly raises HDL cholesterol and reduces inflammatory markers. However, mechanistic understanding into its wide range of actions remains unclear. The recent identification of the Gi-coupled protein receptor HCAR2, for which NA is a potent agonist, provides intriguing insight due to its anti-lipolytic action and restricted, yet specific, expression in adipose tissue and immune cells. The HCAR2 gene is 96% homologous to HCAR3, but the HCAR3 receptor shares neither the specificity for NA, nor the range of functional effects. Moreover, the close homology makes it difficult to separate the genetic variability and regulation of the two genes. To this end, I resequenced HCAR2 and HCAR3 in a selected population to characterize the variability of the two genes and to inform the subsequent design of specific genotyping assays. The Oxford Biobank, which is a random population-based collection of 30-50 year old men and women in Oxfordshire with a wide range of collected phenotypes, was used to explore genetic associations. A preliminary trend with HDL and rs7314976 in HCAR2 motivated the further search associations. However after increasing the sample size, the HDL association did not reach significance. When looking at inflammatory phenotypes, a 20% lower level of systemic hsCRP was found in males with a promoter region variant in HCAR3 (N=1808, p=0.007 for rs55718746). Replication of this finding in two relevant cohorts (NPHS-II, N=2185 and Whitehall, N=4228) resulted in conflicting findings. After optimising the specific detection of both HCAR2 and HCAR3 transcripts, I characterized gene expression in human AT biopsies. This revealed an 18% increase in HCAR2 expression in the female abdominal depot (N=106, p<0.0001) and a reduction in abdominal HCAR2 in both males (β=-0.37, p<0.001, N=107) and females (β=-0.251, p=0.005, N=106) with increasing adiposity. The rs55718746 variant in HCAR3 was also seen to influence expression of both HCAR2 (N=182, p=0.018 in the abdominal depot) and HCAR3 (N=198, p=0.005) but surprisingly in opposite directions, establishing it as the first cis-eQTL for this genomic region. Finally, I used human adipocyte in vitro culture systems to setup a pilot to study the anti-inflammatory effects of NA. The gene expression of HCAR2 and HCAR3 increased significantly with adipocyte differentiation in vitro. NA led to a drop in IL-6 transcript abundance in two out of three of the in vitro differentiated human adipocytes. In conclusion, genetic variability in HCAR2 and HCAR3 shows weak associations with cardiovascular disease risk phenotypes relating to their respective pathways. The relevance of HCAR2 and HCAR3 gene expression and the role of the receptor in the control of inflammation will require further studies.

Subjects/Keywords: 611; Genetics (life sciences); Metabolism; Medical Sciences; Cardiovascular disease; Genetics (medical sciences); niacin; nicotinic acid receptor; genetics; polymorphisms; human; adipose tissue

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APA (6^th Edition):

Chamas, L. (2013). The nicotinic acid receptor in human adipose tissue. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:82650691-be95-4cf7-a3cd-e0821062f49d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604411

Chicago Manual of Style (16^th Edition):

Chamas, Liliane. “The nicotinic acid receptor in human adipose tissue.” 2013. Doctoral Dissertation, University of Oxford. Accessed March 05, 2021. http://ora.ox.ac.uk/objects/uuid:82650691-be95-4cf7-a3cd-e0821062f49d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604411.

MLA Handbook (7^th Edition):

Chamas, Liliane. “The nicotinic acid receptor in human adipose tissue.” 2013. Web. 05 Mar 2021.

Vancouver:

Chamas L. The nicotinic acid receptor in human adipose tissue. [Internet] [Doctoral dissertation]. University of Oxford; 2013. [cited 2021 Mar 05]. Available from: http://ora.ox.ac.uk/objects/uuid:82650691-be95-4cf7-a3cd-e0821062f49d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604411.

Council of Science Editors:

Chamas L. The nicotinic acid receptor in human adipose tissue. [Doctoral Dissertation]. University of Oxford; 2013. Available from: http://ora.ox.ac.uk/objects/uuid:82650691-be95-4cf7-a3cd-e0821062f49d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604411

27. Brumley, Conrad Scott. Influence of edaphic factors and phenological development on niacin and thiamine in honey mesquite.

Degree: Agriculture, 1978, Texas Tech University

URL: http://hdl.handle.net/2346/19820

Subjects/Keywords: Vitamin B1; Mesquite – Ecology; Niacin; Phenology

…grown at sub-optimal temperatures when either niacin or thiamine was foliarly applied to the… …dichlorophenoxyacetic acid (2,4-D), Niacin added to 2,4,5-T markedly increased root kills of… …niacin and thiamine concentrations in roots of seedling honey mesquite were influenced by soil… …niacin and thiamine concentrations. The concentration of niacin in the roots of plants grown… …in the 21 C regime was lowest while the concentration of niacin in the roots of plants from…

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APA (6^th Edition):

Brumley, C. S. (1978). Influence of edaphic factors and phenological development on niacin and thiamine in honey mesquite. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/19820

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brumley, Conrad Scott. “Influence of edaphic factors and phenological development on niacin and thiamine in honey mesquite.” 1978. Thesis, Texas Tech University. Accessed March 05, 2021. http://hdl.handle.net/2346/19820.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brumley, Conrad Scott. “Influence of edaphic factors and phenological development on niacin and thiamine in honey mesquite.” 1978. Web. 05 Mar 2021.

Vancouver:

Brumley CS. Influence of edaphic factors and phenological development on niacin and thiamine in honey mesquite. [Internet] [Thesis]. Texas Tech University; 1978. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2346/19820.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brumley CS. Influence of edaphic factors and phenological development on niacin and thiamine in honey mesquite. [Thesis]. Texas Tech University; 1978. Available from: http://hdl.handle.net/2346/19820

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

28. Zimbelman, Rosemarie Burgos. Management Strategies to Reduce Effects of Thermal Stress on Lactating Dairy Cattle .

Degree: 2008, University of Arizona

URL: http://hdl.handle.net/10150/195322

► Two strategies to reduce impact of heat stress on high producing dairy cows were examined. The first was to recalculate the temperature-humidity index (THI) using… (more)

▼ Two strategies to reduce impact of heat stress on high producing dairy cows were examined. The first was to recalculate the temperature-humidity index (THI) using high producing dairy cows under diurnal summer conditions. This re-evaluation confirmed that current THI values underestimate the severity of heat stress levels. Therefore, cooling of dairy cattle during warm summer months should begin at a THI of 68. Previously, a THI equal to or greater than 72 has been used to define onset of heat stress. This study demonstrated that a THI greater than or equal to 68 is sufficient to increase body heat storage, respiration rate, skin evaporative heat loss, declines in feed intake and milk yield. A second objective involved three studies carried out to evaluate use of niacin in dairy cow rations to improve evaporative heat loss and resistance to heat stress. Niacin is known to cause intense vasodilation in human and lab species. We hypothesized that increasing vasodilation would improve evaporative heat loss in dairy cows. In the first niacin study, supplementation of lactating dairy cows with an encapsulated rumen by-pass form of niacin (NIASHURE™; Balchem Corporation, New Hampton, NY) at a dose of 12 g/d proved effective in alleviating some affects of heat stress during mild thermal stress. We hypothesized that encapsulated niacin would induce vasodilation effects documented in humans and lab animals increasing evaporative heat loss. Past research demonstrated that the possible mechanism for vasodilation affects seen by niacin were most likely due to prostaglandin D secretions. Niacin may act through increased prostaglandin D and E production and secretion by Langerhans cells which then act upon vascular endothelial prostaglandin D receptors to increase vasodilation. No studies have evaluated impact of encapsulated niacin on milk yield and composition during periods of thermal stress under commercial dairy conditions. The objective of the last study was to examine the effects of encapsulated niacin during heat stress on milk production and composition as well as core body temperatures under commercial conditions. Advisors/Committee Members: Collier, Robert J (advisor), Baumgard, Lance H (committeemember), Duff, Glenn C (committeemember), Bilby, Todd R (committeemember), Foster, Billye (committeemember).

Subjects/Keywords: Heat stress; niacin; temperature humidity index; THI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zimbelman, R. B. (2008). Management Strategies to Reduce Effects of Thermal Stress on Lactating Dairy Cattle . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/195322

Chicago Manual of Style (16^th Edition):

Zimbelman, Rosemarie Burgos. “Management Strategies to Reduce Effects of Thermal Stress on Lactating Dairy Cattle .” 2008. Doctoral Dissertation, University of Arizona. Accessed March 05, 2021. http://hdl.handle.net/10150/195322.

MLA Handbook (7^th Edition):

Zimbelman, Rosemarie Burgos. “Management Strategies to Reduce Effects of Thermal Stress on Lactating Dairy Cattle .” 2008. Web. 05 Mar 2021.

Vancouver:

Zimbelman RB. Management Strategies to Reduce Effects of Thermal Stress on Lactating Dairy Cattle . [Internet] [Doctoral dissertation]. University of Arizona; 2008. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10150/195322.

Council of Science Editors:

Zimbelman RB. Management Strategies to Reduce Effects of Thermal Stress on Lactating Dairy Cattle . [Doctoral Dissertation]. University of Arizona; 2008. Available from: http://hdl.handle.net/10150/195322

University of Helsinki

29. Aalto, Sanni. Folaatin, niasiinin, B2- ja B12-vitamiinin pitoisuus kaupallisissa mikrolevävalmisteissa ja laboratorio-olosuhteissa kasvatetuissa mikrolevissä.

Degree: Department of Food and Environmental Sciences; Helsingfors universitet, Agrikultur- och forstvetenskapliga fakulteten, Institutionen för livsmedels- och miljövetenskaper, 2017, University of Helsinki

URL: http://hdl.handle.net/10138/181464

► Microalgae are promising raw materials for food- and biotechnology because they contain a lot of proteins, unsaturated fatty acids, pigments, vitamins and minerals. There are… (more)

▼ Microalgae are promising raw materials for food- and biotechnology because they contain a lot of proteins, unsaturated fatty acids, pigments, vitamins and minerals. There are few studies on vitamin B in microalgae and some of them are based on partly inaccurate methods. Microalgae in general, analytical methods regarding their analysis and how they use vitamins were discussed in the literature part of this thesis. The structures, chemical properties and occurrence in foods as well as commonly used analytical methods of the vitamins in question were presented. The aim of the experimental part of this thesis was to analyse commercially marketed microalgae supplements (Chlorella sp. and Arthrospira sp. (spirulina)) and laboratory-grown microalga (Euglena gracilis) as potential sources of folate, niacin, vitamin B2 and B12. Contents of vitamin B12, B2 and niacin were analysed using UHPLC method separately validated for each vitamin. The total folate content was analysed microbiologically and folate vitamers by using UHPLC. The vitamin B12 was analysed microbiologically and the active forms of vitamin B12 were confirmed using LC-MS. Acid hydrolysis was used in analysing niacin content. The total folate content in chlorella supplements was of the same order when analysed microbiologically or with UHPLC. Instead, in spirulina supplements the microbiologically analysed total folate content was higher than the total folate content based on the sum of folate vitamers analysed with UHPLC. At most, the total folate content of E. gracilis -sample was 3-fold higher than in commercial microalgae supplements. Especially in spirulina supplements, the vitamin B12 contents were clearly higher when analysed microbiologically than they were when analysed with UHPLC. The difference was most likely due to pseudocobalamin that resembled vitamin B12. On average E. gracilis -samples had higher vitamin B2 content than the commercial supplements. E. gracilis -samples and chlorella supplements contained more niacin than spirulina supplements. According to this thesis, commercially marketed microalgae supplements contained different amounts of vitamin B. Chlorella sp. was proved to be a great source of folate, vitamin B12 and niacin and moderate source of B2. The majority of vitamin B12 in Arthrospira sp. (spirulina) was pseudocobalamin. Despite that, spirulina supplements proved to be a moderate source of vitamin B12. On average, E. gracilis had the highest vitamin B content and it would potentially be an excellent source of vitamin B – if it was accepted for food use.

Subjects/Keywords: chlorella; spirulina; euglena; UHPLC; MBA; microalgae; folate; niacin; riboflavin; vitamin B12; mikrolevä; folaatti; niasiini; riboflaviini; B12-vitamiini; Livsmedelskemi; Food Chemistry; Elintarvikekemia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aalto, S. (2017). Folaatin, niasiinin, B2- ja B12-vitamiinin pitoisuus kaupallisissa mikrolevävalmisteissa ja laboratorio-olosuhteissa kasvatetuissa mikrolevissä. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/181464

Chicago Manual of Style (16^th Edition):

Aalto, Sanni. “Folaatin, niasiinin, B2- ja B12-vitamiinin pitoisuus kaupallisissa mikrolevävalmisteissa ja laboratorio-olosuhteissa kasvatetuissa mikrolevissä.” 2017. Masters Thesis, University of Helsinki. Accessed March 05, 2021. http://hdl.handle.net/10138/181464.

MLA Handbook (7^th Edition):

Aalto, Sanni. “Folaatin, niasiinin, B2- ja B12-vitamiinin pitoisuus kaupallisissa mikrolevävalmisteissa ja laboratorio-olosuhteissa kasvatetuissa mikrolevissä.” 2017. Web. 05 Mar 2021.

Vancouver:

Aalto S. Folaatin, niasiinin, B2- ja B12-vitamiinin pitoisuus kaupallisissa mikrolevävalmisteissa ja laboratorio-olosuhteissa kasvatetuissa mikrolevissä. [Internet] [Masters thesis]. University of Helsinki; 2017. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10138/181464.

Council of Science Editors:

Aalto S. Folaatin, niasiinin, B2- ja B12-vitamiinin pitoisuus kaupallisissa mikrolevävalmisteissa ja laboratorio-olosuhteissa kasvatetuissa mikrolevissä. [Masters Thesis]. University of Helsinki; 2017. Available from: http://hdl.handle.net/10138/181464

30. El Khoury, Petra. Modulation pharmacologique et génétique de la fonctionnalité des particules HDL : Conséquences sur le risque cardiovasculaire et le développement de l'athérosclérose : Pharmacological and genetic modulation of HDL functionality : consequences on cardiovascular risk and atherosclerosis progression.

Degree: Docteur es, Physiologie, Physiopathologie et thérapeutique, 2014, Université Pierre et Marie Curie – Paris VI

URL: http://www.theses.fr/2014PA066482

►

Les résultats des études cliniques récentes évaluant l'impact de l'augmentation du HDL-C sur la survenue des maladies cardiovasculaires n'ont pas permis de démontrer une efficacité… (more)

▼

Les résultats des études cliniques récentes évaluant l'impact de l'augmentation du HDL-C sur la survenue des maladies cardiovasculaires n'ont pas permis de démontrer une efficacité significative de cette stratégie thérapeutique ciblée sur le HDL-C. L'évaluation de la fonctionnalité des particules HDL dans sa capacité à assurer le retour du cholestérol des tissus périphériques au foie s'avère plus importante que la simple mesure du HDL-C. L'objectif de mes travaux de recherche a été d'évaluer la fonctionnalité des particules HDL en fonction du contexte métabolique, inflammatoire et génétique de chaque individu. Mes travaux de recherche ont démontré que la niacine réduit l'athérogénicité des lipoprotéines durant la période postprandiale modulant par conséquent la fonctionnalité des particules HDL dans la voie du transport inverse de cholestérol. J'ai également montré que certaines pathologies infectieuses associées à des taux bas de HDL-C, entrainent une baisse de la capacité des particules HDL à stimuler l'efflux de cholestérol à travers le macrophage humain. En revanche, j'ai montré que des variations génétiques entrainant des taux élevés de HDL-C ne sont pas associées à une dysfonction des particules HDL dans la voie du transport inverse de cholestérol. Mes travaux soulignent l'importance de considérer que la fonctionnalité des particules HDL est modulée in vivo par des contraintes métaboliques inflammatoires et génétiques d'où il est nécessaire que les thérapies en cours de développement visant à augmenter la fonction des HDL soient résistantes aux modifications métaboliques et inflammatoires afin d'assurer une athéroprotection efficace.

HDL cholesterol as a therapeutic target has been the focus over the past 20 years mainly because its plasma concentrations are inversely correlated with the risk of coronary events. However, recent clinical trials involved the addition of niacin or CETP inhibitors to a statin in patients with CHD who had well controlled LDL-C levels have failed to show evidence of a significant reduction in cardiovascular events. Studies on the capacity of HDL to promote reverse cholesterol transport pathway have suggested that this is a better predictor of prevalent atherosclerotic disease than HDL-C itself. The main purpose of my project was to evaluate the impact of metabolic context, inflammation and genetics on modulation of HDL functionality. I have shown that extended release niacin/laropiprant treatment reduces atherogenic postprandial lipoproteins in patients with metabolic disorders stabilized by statins, having consequences on reverse cholesterol transport pathway and HDL functionality. Moreover, I have shown that infectious diseases such as HIV, induce an alteration in the capacity of HDL particles to stimulate cholesterol efflux from human macrophages. I have also shown that mutations causing high levels of HDL-C, are characterized by the presence of functional HDL in their capacity to stimulate reverse cholesterol pathway. However such patients are not systematically protected…

Advisors/Committee Members: Abi Fadel, Marianne (thesis director), Guérin, Maryse (thesis director).

Subjects/Keywords: Hdl (lipoprotéines de haute densité); Efflux de cholestérol; Risque cardiovasculaire; Niacine; Virus de l'immunodéficience humaine; Cetp.; Cholesterol efflux; Niacin; 612

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

El Khoury, P. (2014). Modulation pharmacologique et génétique de la fonctionnalité des particules HDL : Conséquences sur le risque cardiovasculaire et le développement de l'athérosclérose : Pharmacological and genetic modulation of HDL functionality : consequences on cardiovascular risk and atherosclerosis progression. (Doctoral Dissertation). Université Pierre et Marie Curie – Paris VI. Retrieved from http://www.theses.fr/2014PA066482

Chicago Manual of Style (16^th Edition):

El Khoury, Petra. “Modulation pharmacologique et génétique de la fonctionnalité des particules HDL : Conséquences sur le risque cardiovasculaire et le développement de l'athérosclérose : Pharmacological and genetic modulation of HDL functionality : consequences on cardiovascular risk and atherosclerosis progression.” 2014. Doctoral Dissertation, Université Pierre et Marie Curie – Paris VI. Accessed March 05, 2021. http://www.theses.fr/2014PA066482.

MLA Handbook (7^th Edition):

El Khoury, Petra. “Modulation pharmacologique et génétique de la fonctionnalité des particules HDL : Conséquences sur le risque cardiovasculaire et le développement de l'athérosclérose : Pharmacological and genetic modulation of HDL functionality : consequences on cardiovascular risk and atherosclerosis progression.” 2014. Web. 05 Mar 2021.

Vancouver:

El Khoury P. Modulation pharmacologique et génétique de la fonctionnalité des particules HDL : Conséquences sur le risque cardiovasculaire et le développement de l'athérosclérose : Pharmacological and genetic modulation of HDL functionality : consequences on cardiovascular risk and atherosclerosis progression. [Internet] [Doctoral dissertation]. Université Pierre et Marie Curie – Paris VI; 2014. [cited 2021 Mar 05]. Available from: http://www.theses.fr/2014PA066482.

Council of Science Editors:

El Khoury P. Modulation pharmacologique et génétique de la fonctionnalité des particules HDL : Conséquences sur le risque cardiovasculaire et le développement de l'athérosclérose : Pharmacological and genetic modulation of HDL functionality : consequences on cardiovascular risk and atherosclerosis progression. [Doctoral Dissertation]. Université Pierre et Marie Curie – Paris VI; 2014. Available from: http://www.theses.fr/2014PA066482

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