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University of Sydney

1. Chatterjee, Aritrick. Redefining the biophysical basis of contrast in diffusion-weighted MRI of the prostate .

Degree: 2016, University of Sydney

Purpose: The study investigates the hypothesis that the clinically observed decrease in ADC with increasing prostate cancer Gleason grade can be attributed to an increasing volume of low diffusivity epithelial cells, and corresponding decreasing volumes of higher diffusivity stroma and lumen space, rather than increased cell density. Methods: Whole human prostates and tissue cores were imaged post radical prostatectomy on 9.4T and 16.4T Bruker MRI systems respectively. Digital histology images were analysed andDWI measurements were correlated with regions of interest in the prostate specimens. The morphometric measured volumes and diffusivities of these distinct tissue components were used to predict ADC. Results: There was a stronger correlationof Gleason pattern with gland component volumes (n=553) of epithelium (ρ=0.898), stroma (ρ=-0.651), and lumen (ρ=-0.912), than with cellularity metrics (n=288) nuclear area (ρ=0.422) or count (ρ=0.081). There was a stronger correlation between measured ADC and epithelium (r=0.688) and lumen volume (r=-0.647), than between measured ADC and nuclear count (r =-0.598) or area (r=-0.569) (n=57). The differences between cancer and normal tissue, and correlations with pathology are stronger, for the gland component volumes than for the cellularity metrics. ADC predicted (n=118) showed the strongest correlation (r=0.935) with measured ADC and follows the trends seen clinically. Conclusion: Differences in the gland compartment volumes of prostate tissue having distinct diffusivities, rather than changes in the conventionally cited ‘cellularity’ metrics, are the major contributor to clinically observed variations of ADC in prostate tissue. The findings affect the interpretation of prostate DWI in terms of tissue structure and indicate a closer relationship between diffusion contrast and the histopathologic features of cancer than previously assumed.

Subjects/Keywords: cellularity; Gleason grade; diffusion MRI; prostate; ADC; morphomtery

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chatterjee, A. (2016). Redefining the biophysical basis of contrast in diffusion-weighted MRI of the prostate . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/15400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Chatterjee, Aritrick. “Redefining the biophysical basis of contrast in diffusion-weighted MRI of the prostate .” 2016. Thesis, University of Sydney. Accessed September 26, 2020. http://hdl.handle.net/2123/15400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Chatterjee, Aritrick. “Redefining the biophysical basis of contrast in diffusion-weighted MRI of the prostate .” 2016. Web. 26 Sep 2020.

Vancouver:

Chatterjee A. Redefining the biophysical basis of contrast in diffusion-weighted MRI of the prostate . [Internet] [Thesis]. University of Sydney; 2016. [cited 2020 Sep 26]. Available from: http://hdl.handle.net/2123/15400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chatterjee A. Redefining the biophysical basis of contrast in diffusion-weighted MRI of the prostate . [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/15400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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