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1. Goka, Edward Anthony Chilongo. Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality.

Degree: 2014, University of Manchester

Introduction: Epidemiological studies have indicated that 5-38% of influenza like illnesses (ILI) develop into severe disease due to, among others, factors such as; underlying chronic diseases, age, pregnancy, and viral mutations. There are suggestions that dual or multiple virus infections may affect disease severity. This study investigated the association between co-infection between influenza A viruses and other respiratory viruses and disease severity. Methodology: Datum for samples from North West England tested between January 2007 and June 2012 was analysed for patterns of co-infection between influenza A viruses and ten respiratory viruses. Risk of hospitalization to a general ward ICU or death in single versus mixed infections was assessed using multiple logistic regression models. Results: One or more viruses were identified in 37.8% (11,715/30,975) of samples, of which 10.4% (1,214) were mixed infections and 89.6% (10,501) were single infections. Among patients with influenza A(H1N1)pdm09, co-infections occurred in 4.7% (137⁄2,879) vs. 6.5% (59⁄902) in those with seasonal influenza A virus infection. In general, patients with mixed respiratory virus infections had a higher risk of admission to a general ward (OR: 1.43, 95% CI: 1.2 – 1.7, p = <0.0001) than those with a single infection. Co-infection between seasonal influenza A viruses and influenza B virus was associated with a significant increase in the risk of admission to ICU/ death (OR: 22.0, 95% CI: 2.21 – 219.8 p = 0.008). RSV/seasonal influenza A viruses co-infection also associated with increased risk but this was not statistically significant. For the pandemic influenza A(H1N1)pdm09 virus, RSV and AdV co-infection increased risk of hospitalization to a general ward, whereas Flu B increased risk of admission to ICU/ death, but none of these were statistically significant. Considering only single infections, RSV and hPIV1-3 increased risk of admission to a general ward (OR: 1.49, 95% CI: 1.28 – 1.73, p = <0.0001 and OR: 1.34, 95% CI: 1.003 – 1.8, p = 0.05) and admission to ICU/ death (OR: 1.5, 95% CI: 1.20 – 2.0, p = <0.0001 and OR: 1.60, 95% CI: 1.02 – 2.40, p = 0.04). Conclusion: Co-infection is a significant predictor of disease outcome; there is insufficient public health data on this subject as not all samples sent for investigation of respiratory virus infection are tested for all respiratory viruses. Integration of testing for respiratory viruses’ co-infections into routine clinical practice and R&D on integrated drugs and vaccines for influenza A&B, RSV, and AdV, and development of multi-target diagnostic tests is encouraged.

Introduction: Studies indicate that up to a third (5-38%) of patients with flu develop serious disease. A number of reasons makes this happen; in some cases, flu is more severe when it attacks individuals who have lifelong illnesses like diabetes, or with other risk factors. Some reports have suggested that being infected with more than one respiratory virus increases the chances of developing more severe flu. This…

Advisors/Committee Members: KLAPPER, PAUL P, Vallely, Pamela, Klapper, Paul.

Subjects/Keywords: influenza A virus; Flu A; pandemic influenza A(H1N1)pdm09; respiratory virus infections; influenza B virus; Flu B; respiratory syncytial virus; RSV; rhinovirus; RV; adenovirus; AdV; human metapneumovirus; hMPV; parainfluenza virus types 1 to 3; hPIV1-3; hospitalization; admission to a general ward (GW); admission to an intensive care unit (ICU); death; mortality; severe disease; severity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Goka, E. A. C. (2014). Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:224733

Chicago Manual of Style (16th Edition):

Goka, Edward Anthony Chilongo. “Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality.” 2014. Doctoral Dissertation, University of Manchester. Accessed September 19, 2020. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:224733.

MLA Handbook (7th Edition):

Goka, Edward Anthony Chilongo. “Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality.” 2014. Web. 19 Sep 2020.

Vancouver:

Goka EAC. Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2020 Sep 19]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:224733.

Council of Science Editors:

Goka EAC. Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality. [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:224733


University of Manchester

2. Goka, Edward Anthony Chilongo. Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality.

Degree: PhD, 2014, University of Manchester

Introduction: Epidemiological studies have indicated that 5-38% of influenza like illnesses (ILI) develop into severe disease due to, among others, factors such as; underlying chronic diseases, age, pregnancy, and viral mutations. There are suggestions that dual or multiple virus infections may affect disease severity. This study investigated the association between co-infection between influenza A viruses and other respiratory viruses and disease severity. Methodology: Datum for samples from North West England tested between January 2007 and June 2012 was analysed for patterns of co-infection between influenza A viruses and ten respiratory viruses. Risk of hospitalization to a general ward ICU or death in single versus mixed infections was assessed using multiple logistic regression models. Results: One or more viruses were identified in 37.8% (11,715/30,975) of samples, of which 10.4% (1,214) were mixed infections and 89.6% (10,501) were single infections. Among patients with influenza A(H1N1)pdm09, co-infections occurred in 4.7% (137⁄2,879) vs. 6.5% (59⁄902) in those with seasonal influenza A virus infection. In general, patients with mixed respiratory virus infections had a higher risk of admission to a general ward (OR: 1.43, 95% CI: 1.2 – 1.7, p = <0.0001) than those with a single infection. Co-infection between seasonal influenza A viruses and influenza B virus was associated with a significant increase in the risk of admission to ICU/ death (OR: 22.0, 95% CI: 2.21 – 219.8 p = 0.008). RSV/seasonal influenza A viruses co-infection also associated with increased risk but this was not statistically significant. For the pandemic influenza A(H1N1)pdm09 virus, RSV and AdV co-infection increased risk of hospitalization to a general ward, whereas Flu B increased risk of admission to ICU/ death, but none of these were statistically significant. Considering only single infections, RSV and hPIV1-3 increased risk of admission to a general ward (OR: 1.49, 95% CI: 1.28 – 1.73, p = <0.0001 and OR: 1.34, 95% CI: 1.003 – 1.8, p = 0.05) and admission to ICU/ death (OR: 1.5, 95% CI: 1.20 – 2.0, p = <0.0001 and OR: 1.60, 95% CI: 1.02 – 2.40, p = 0.04). Conclusion: Co-infection is a significant predictor of disease outcome; there is insufficient public health data on this subject as not all samples sent for investigation of respiratory virus infection are tested for all respiratory viruses. Integration of testing for respiratory viruses’ co-infections into routine clinical practice and R&D on integrated drugs and vaccines for influenza A&B, RSV, and AdV, and development of multi-target diagnostic tests is encouraged.

Subjects/Keywords: 616.2; influenza A virus, Flu A, pandemic influenza A(H1N1)pdm09, respiratory virus infections, influenza B virus, Flu B, respiratory syncytial virus, RSV, rhinovirus, RV, adenovirus, AdV, human metapneumovirus, hMPV, parainfluenza virus types 1 to 3, hPIV1-3, hospitalization, admission to a general ward (GW), admission to an intensive care unit (ICU), death, mortality, severe disease, severity

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Goka, E. A. C. (2014). Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/influenza-a-viruses-dual-and-multiple-infections-with-other-respiratory-viruses-and-risk-of-hospitalization-and-mortality(256eb122-a52a-4276-8dc1-28b5a2cc6662).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617956

Chicago Manual of Style (16th Edition):

Goka, Edward Anthony Chilongo. “Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality.” 2014. Doctoral Dissertation, University of Manchester. Accessed September 19, 2020. https://www.research.manchester.ac.uk/portal/en/theses/influenza-a-viruses-dual-and-multiple-infections-with-other-respiratory-viruses-and-risk-of-hospitalization-and-mortality(256eb122-a52a-4276-8dc1-28b5a2cc6662).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617956.

MLA Handbook (7th Edition):

Goka, Edward Anthony Chilongo. “Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality.” 2014. Web. 19 Sep 2020.

Vancouver:

Goka EAC. Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2020 Sep 19]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/influenza-a-viruses-dual-and-multiple-infections-with-other-respiratory-viruses-and-risk-of-hospitalization-and-mortality(256eb122-a52a-4276-8dc1-28b5a2cc6662).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617956.

Council of Science Editors:

Goka EAC. Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality. [Doctoral Dissertation]. University of Manchester; 2014. Available from: https://www.research.manchester.ac.uk/portal/en/theses/influenza-a-viruses-dual-and-multiple-infections-with-other-respiratory-viruses-and-risk-of-hospitalization-and-mortality(256eb122-a52a-4276-8dc1-28b5a2cc6662).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617956

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