subject:( en EDUCATION S TECHNOLOGY)

Pontifical Catholic University of Rio de Janeiro

1. ROBERTO TODOR. [en] TAXONOMY OF EDUCATIONAL GAMES.

Degree: 2018, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=33669

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[pt] As tecnologias da informação e comunicação (TICs) vêm avançando de forma continuada e se amalgamando à cultura de uma grande parcela da juventude mundial,… (more)

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[pt] As tecnologias da informação e comunicação (TICs) vêm avançando de forma continuada e se amalgamando à cultura de uma grande parcela da juventude mundial, inclusive a brasileira. Nessa pesquisa, citamos o processo pelo qual está passando os espaços de ensino-aprendizagem, do qual, aos poucos, estão acolhendo a demanda desse público-alvo, de jovens estudantes, que desejam estar conectados durante suas atividades escolares. Contudo, muitos games com suas habilidades e competências têm contribuído para o aprendizado e podem cumprir muitas tarefas, inclusive a de reaproximar estudantes que estejam desestimulados com o ensino do dia-a-dia. A sociedade, por sua vez, vem acompanhando esse processo e, nesse documento, apresentamos um histórico de como evoluímos com os games desde os arcades até chegarem aos celulares. Como consequência dessa evolução tecnológica, há uma profusão de títulos de games para os dispositivos móveis, muitos deles educativos, o que vem de encontro com a necessidade de crianças e jovens em idade escolar. Em seguida, apresentamos um estudo dos artifícios que fazem desses games tão atrativos a esse público. Com todo esse subsídio, a pesquisa propõe a formatação de uma taxonomia para games educativos, a fim de oferecer subsídios para que alunos, seus pais e professores tenham facilidade em identificar games que possam contribuir para o seu aprendizado.

[en] Information and communication technologies have been consistently moving forward and impacting a segment of the youth population across cultures, including Brazil. In this research paper we examine the transformations occurring in the field of education, both from a teaching and a learning perspective. These two arenas have gradually been taking on current demands from their target audience, the youth, who desire to stay connected while performing their typical school work. As a result, many educational games emphasizing particular skills contribute to learning and can end up playing a number of roles, one of wich is to reengage demotivated students in their day to day learning activities. Meanwhile, society as a whole has been paralleling this transformation. This paper presents a history of the evolution of games, from the arcades to the latest cell phone platforms, and how the myriad of mobile educational games has been meeting the academic needs of school age children. We present a closer look at the tools and devices that make them so attractive to this particular age segment of the population. Our research proposes the implamentation of taxonomy exclusively of educational games, aiming to facilitate their identification of games that contribute to learning for students and their parents and teachers.

Advisors/Committee Members: RITA MARIA DE SOUZA COUTO.

Subjects/Keywords: [pt] EDUCACAO; [en] EDUCATION; [pt] JOGOS DIGITAIS; [en] DIGITAL GAMES; [pt] ENSINO-APRENDIZAGEM; [en] TEACHING AND LEARNING; [pt] TAXONOMIA DE GAMES; [en] TAXONOMY OF EDUCATIONAL GAMES; [pt] OBJETOS DE APRENDIZADO DIGITAIS; [en] DIGITAL LEARNING OBJECTS; [pt] TECNOLOGIA NA EDUCACAO; [en] EDUCATION S TECHNOLOGY

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

TODOR, R. (2018). [en] TAXONOMY OF EDUCATIONAL GAMES. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=33669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

TODOR, ROBERTO. “[en] TAXONOMY OF EDUCATIONAL GAMES.” 2018. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=33669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

TODOR, ROBERTO. “[en] TAXONOMY OF EDUCATIONAL GAMES.” 2018. Web. 09 Dec 2019.

Vancouver:

TODOR R. [en] TAXONOMY OF EDUCATIONAL GAMES. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2018. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=33669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

TODOR R. [en] TAXONOMY OF EDUCATIONAL GAMES. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2018. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=33669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Wlaszyn, Joanna. Dimension (in)visible : réception technologique comme valeur ajoutée vers une architecture amplifiée : (In)visible dimension : technological reception as added value to amplified architecture.

Degree: Docteur es, Architecture, 2012, Université Paris-Est

URL: http://www.theses.fr/2012PEST1187

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L'objet de cette recherche consiste à capturer et analyser les relations entre l'architecture et les technologies récentes sous l'angle de la perception. Loin de la… (more)

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L'objet de cette recherche consiste à capturer et analyser les relations entre l'architecture et les technologies récentes sous l'angle de la perception. Loin de la subjectivité supposée, l‘analyse guidée par la notion d'expérience perceptive s'appuie à la fois sur des concepts esthétiques et phénoménologiques. Cette double réflexivité porte également sur une étude de cas conceptuels et « concrets » qui opèrent la vision de la spatialité architecturale dans des tensions spéculatives entre le monde « numérique » et physique. La problématique porte sur la réception de l'architecture comme valeur culturelle et production intellectuelle, coordonnée par des moyens technologiques qui l'amplifient. S'inscrivant dans l'hypothèse qu'aujourd'hui l'architecture est loin de « servir » uniquement de réponse aux questions formelles, structurelles et fonctionnelles, la recherche démontre que l'architecture s'approche de plus en plus du champ artistique en phase d'expérimentations permanentes. Analysant les facteurs d'esthétisation de concepts variés, l'étude des cas vise à appréhender l'aspect cognitif et la valeur esthétique de la réception technologique — notion nouvelle, introduite comme un outil opératoire permettant d'aborder les aspects sensibles, hybrides et variables de la production architecturale. L'originalité de cette recherche consiste donc à analyser les connexions instables qui caractérisent les processus actuels de transitions diverses dans le domaine de l'architecture. À ce titre, cette recherche propose d'ouvrir le champ de la discussion autour du « digital » selon les principes de la singularité architecturale dans la pluralité des réceptions possibles

The purpose of this research is to capture and analyze the relationships between architecture and recent technologies in terms of perception. Far from the supposed subjectivity, this analysis guided by the notion of perceptual experience, is based on both phenomenological and aesthetic concepts. This double reflexivity also relates to the conceptual and "concrete" case studies operating the architectural vision of spatiality in speculative tensions between the "digital" and the physical word. The problematic concerns the reception of architecture as a cultural value and intellectual production, coordinated by technological means that amplify it. In keeping with the assumption that today's architecture is far away to "serve" only as a response to formal, structural and functional questions, this research shows that architecture is increasingly approaching the artistic field in phase of permanent experimentations. By analyzing the factors of aestheticization of various concepts, case study seeks to understand the cognitive and the aesthetic value of the technological reception — new notion, introduced as an operational concept to approach the sensitive, hybrid and variables issues of architectural production. The originality of this research consist of analyzing the unstable connections that characterize the current processes of various transitions in the field of…

Advisors/Committee Members: Fol, Jac (thesis director).

Subjects/Keywords: Architecture(s); Technologie(s); Réception(s); Perception(s); Amplification(s); Architecture(s); Technology(ies); Reception(s); Perception(s); Amplification(s)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wlaszyn, J. (2012). Dimension (in)visible : réception technologique comme valeur ajoutée vers une architecture amplifiée : (In)visible dimension : technological reception as added value to amplified architecture. (Doctoral Dissertation). Université Paris-Est. Retrieved from http://www.theses.fr/2012PEST1187

Chicago Manual of Style (16^th Edition):

Wlaszyn, Joanna. “Dimension (in)visible : réception technologique comme valeur ajoutée vers une architecture amplifiée : (In)visible dimension : technological reception as added value to amplified architecture.” 2012. Doctoral Dissertation, Université Paris-Est. Accessed December 09, 2019. http://www.theses.fr/2012PEST1187.

MLA Handbook (7^th Edition):

Wlaszyn, Joanna. “Dimension (in)visible : réception technologique comme valeur ajoutée vers une architecture amplifiée : (In)visible dimension : technological reception as added value to amplified architecture.” 2012. Web. 09 Dec 2019.

Vancouver:

Wlaszyn J. Dimension (in)visible : réception technologique comme valeur ajoutée vers une architecture amplifiée : (In)visible dimension : technological reception as added value to amplified architecture. [Internet] [Doctoral dissertation]. Université Paris-Est; 2012. [cited 2019 Dec 09]. Available from: http://www.theses.fr/2012PEST1187.

Council of Science Editors:

Wlaszyn J. Dimension (in)visible : réception technologique comme valeur ajoutée vers une architecture amplifiée : (In)visible dimension : technological reception as added value to amplified architecture. [Doctoral Dissertation]. Université Paris-Est; 2012. Available from: http://www.theses.fr/2012PEST1187

Pontifical Catholic University of Rio de Janeiro

3. MARIA CLAUDIA BOLSHAW. [en] ANIMATION: A LANGUAGE WITH VOCATION FOR INCLUSION.

Degree: 2017, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=29584

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[pt] Esta tese apresenta o processo e os resultados de uma pesquisa sobre a linguagem da Animação e seu potencial expressivo para a formação educacional… (more)

Subjects/Keywords: [pt] TECNOLOGIA; [en] TECHNOLOGY; [pt] EDUCACAO ESPECIAL; [en] SPECIAL EDUCATION; [pt] ANIMACAO; [en] ANIMATION; [pt] OFICINA; [pt] SINDROMES

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

BOLSHAW, M. C. (2017). [en] ANIMATION: A LANGUAGE WITH VOCATION FOR INCLUSION. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=29584

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BOLSHAW, MARIA CLAUDIA. “[en] ANIMATION: A LANGUAGE WITH VOCATION FOR INCLUSION.” 2017. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=29584.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BOLSHAW, MARIA CLAUDIA. “[en] ANIMATION: A LANGUAGE WITH VOCATION FOR INCLUSION.” 2017. Web. 09 Dec 2019.

Vancouver:

BOLSHAW MC. [en] ANIMATION: A LANGUAGE WITH VOCATION FOR INCLUSION. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=29584.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BOLSHAW MC. [en] ANIMATION: A LANGUAGE WITH VOCATION FOR INCLUSION. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=29584

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Pontifical Catholic University of Rio de Janeiro

4. ANGILBERTO SABINO DE FREITAS. [en] THE IMPLEMENTATION OF E-LEARNING IN BUSINESS SCHOOLS: AN INTEGRATED MODEL FOR THE PROCESS OF ENVIRONMENT ALIGNMENT.

Degree: 2010, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=15035

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[pt] O uso das Tecnologias de Informação e Comunicação (TIC’s) no processo de ensino, ou e-learning, como estão se tornando conhecidas, seja para uso no… (more)

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[pt] O uso das Tecnologias de Informação e Comunicação (TIC’s) no processo de ensino, ou e-learning, como estão se tornando conhecidas, seja para uso no apoio ao ensino presencial, seja para a educação a distância (EAD), estão, cada vez mais, se tornando uma parte integrante, tanto do ambiente cultural, quanto do ambiente tecnológico da universidade moderna. Quando se observa a introdução e implementação do e-learning nas escolas de gestão brasileiras, tem-se percebido nas recentes experiências que o processo exacerba certas tensões internas. Por outro lado, os estudos na literatura que investigam o fenômeno são, na maioria dos casos, estudos descritivos ou normativos, e que não explicam o processo. Entretanto, sustenta-se que a implementação de tecnologia é um fenômeno complexo e que envolve a interrelação de diversos fatores e que deve ser considerado não somente os aspectos funcionais, mas também o significado que a tecnologia tem para os envolvidos. Com o objetivo de preencher essa lacuna, este estudo buscou compreender como as escolas de gestão gerenciam o processo de implementação do e-learning em seus ambientes a partir do significado que seus gestores atribuem às suas experiências. A partir da análise da experiência de sete escolas com a implementação do e-learning, esta pesquisa propõe uma teoria substantiva do processo, utilizando os procedimentos metodológicos da Grounded Theory (Glaser & Strauss, 1967; Corbin & Strauss, 2008). Foram entrevistados 14 gestores dessas escolas e os resultados da análise revelaram cinco categorias conceituais: 1) a incongruência; 2) a estrutura; 3) a forma de entrada; 4) aculturando o e-learning; e 5) disseminando o elearning que integradas em torno da categoria central – a incongruência – serviram de base para construir um modelo relacional que explica como ocorreu o processo de implementação do e-learning nessas escolas. A conclusão principal que se chegou é que para o processo de implementação do e-learning ser efetivo deve ter claramente em suas premissas que, para que possa ser aceito e disseminado dentro do ambiente interno, deve vir acompanhado de ações que consigam transmitir aos stakeholders uma clara perspectiva de valor relacionada ao uso de tecnologia no processo de ensinoaprendizagem. Somente dessa forma os envolvidos podem perceber os benefícios de seu uso. Assim, a implementação do e-learning, independente do objetivo pela qual a escola introduz em seu ambiente, deve privilegiar a questão pedagógica, definindo estratégias que evidenciem o e-learning como uma ferramenta capaz de melhorar as práticas existentes de ensino, estimulando que se desenvolva internamente uma percepção de valor em relação a ele, caso contrário, não surge a motivação para que o uso da tecnologia possa se disseminar no ambiente. Espera-se que os resultados encontrados contribuam para aumentar o conhecimento sobre o processo de implementação do elearning, principalmente nas escolas de gestão, e para gerar reflexões acerca do fenômeno no contexto brasileiro.

[en] The use of Information…

Advisors/Committee Members: HELENE BERTRAND.

Subjects/Keywords: [pt] EDUCACAO A DISTANCIA - EAD; [en] DISTANCE EDUCATION; [pt] TECNOLOGIA; [en] TECHNOLOGY; [pt] ESCOLAS DE GESTAO

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

FREITAS, A. S. D. (2010). [en] THE IMPLEMENTATION OF E-LEARNING IN BUSINESS SCHOOLS: AN INTEGRATED MODEL FOR THE PROCESS OF ENVIRONMENT ALIGNMENT. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=15035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

FREITAS, ANGILBERTO SABINO DE. “[en] THE IMPLEMENTATION OF E-LEARNING IN BUSINESS SCHOOLS: AN INTEGRATED MODEL FOR THE PROCESS OF ENVIRONMENT ALIGNMENT.” 2010. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=15035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

FREITAS, ANGILBERTO SABINO DE. “[en] THE IMPLEMENTATION OF E-LEARNING IN BUSINESS SCHOOLS: AN INTEGRATED MODEL FOR THE PROCESS OF ENVIRONMENT ALIGNMENT.” 2010. Web. 09 Dec 2019.

Vancouver:

FREITAS ASD. [en] THE IMPLEMENTATION OF E-LEARNING IN BUSINESS SCHOOLS: AN INTEGRATED MODEL FOR THE PROCESS OF ENVIRONMENT ALIGNMENT. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2010. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=15035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

FREITAS ASD. [en] THE IMPLEMENTATION OF E-LEARNING IN BUSINESS SCHOOLS: AN INTEGRATED MODEL FOR THE PROCESS OF ENVIRONMENT ALIGNMENT. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2010. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=15035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Pontifical Catholic University of Rio de Janeiro

5. NATÁLIA BRUNNET. [en] REFLECTIONS ON THE DESIGNER S PRACTICE ON DIGITAL PLAYFUL ACTIVITIES PROJECTS FOR CHILDREN S TEACHING-LEARNING.

Degree: 2018, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34363

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[pt] Os projetos envolvendo tecnologias digitais, design e educação têm uma presença significativa no Brasil e no mundo. Por meio deles, são criados e modificados… (more)

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[pt] Os projetos envolvendo tecnologias digitais, design e educação têm uma presença significativa no Brasil e no mundo. Por meio deles, são criados e modificados serviços, produtos e modelos. No âmbito da educação formal, as atividades lúdicas digitais (ALDs) são recursos usados por professores e alunos durante situações de ensino-aprendizagem em instituições de ensino como escolas, universidades e cursos. Esta pesquisa tem como objetivo caracterizar o desenvolvimento das ALDs para o ensino-aprendizagem de crianças, visando compreender aspectos relativos ao contexto, à experiência de uso e aos processos de projeto. No universo dos projetos, é dado enfoque aos que são idealizados em empresas com estrutura editorial. A investigação se dá sob uma perspectiva multidisciplinar e utiliza como base os achados provenientes de revisão de literatura e de análise de conteúdo de entrevistas realizadas com gestores, professores, editores, designers e programadores. Pretende-se contribuir com os campos do Design e da Educação ao investigar, analisar e discutir métodos, processos, ferramentas e técnicas presentes em projetos de ALDs, bem como empreender reflexões sobre a atuação do designer em projetos desta natureza.

[en] Projects that involve digital technologies, design and education have a significant presence in Brazil and in the world. Through them, services, products and models are created and modified. In the context of formal education, digital playful activities (DPAs) are resources used by teachers and students during teaching-learning situations in educational institutions such as schools, universities and courses. This research aims to characterize the development of DPAs for teaching-learning of children, to understand aspects related to the context and the user experience and design processes. In the universe of projects, the focus is on those that are idealized in companies with an editorial structure. The research takes place from a multidisciplinary perspective and uses as a base the findings from literature review and content analysis of interviews conducted with managers, teachers, editors, designers and programmers. It is intended to contribute to the Design and Education fields by investigating, analyzing and discussing methods, processes, tools and techniques present in DPAs projects, as well as to engage reflections on the designer practice in projects of this nature.

Advisors/Committee Members: RITA MARIA DE SOUZA COUTO.

Subjects/Keywords: [pt] DESIGN; [en] DESIGN; [pt] PROJETO; [en] PROJECT; [pt] EDUCACAO INFANTIL; [en] EARLY CHILDHOOD EDUCATION; [pt] TECNOLOGIA DIGITAL; [en] DIGITAL TECHNOLOGY; [pt] ATIVIDADES LUDICAS DIGITAIS; [en] DIGITAL PLAYFUL ACTIVITIES

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

BRUNNET, N. (2018). [en] REFLECTIONS ON THE DESIGNER S PRACTICE ON DIGITAL PLAYFUL ACTIVITIES PROJECTS FOR CHILDREN S TEACHING-LEARNING. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34363

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BRUNNET, NATÁLIA. “[en] REFLECTIONS ON THE DESIGNER S PRACTICE ON DIGITAL PLAYFUL ACTIVITIES PROJECTS FOR CHILDREN S TEACHING-LEARNING.” 2018. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34363.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BRUNNET, NATÁLIA. “[en] REFLECTIONS ON THE DESIGNER S PRACTICE ON DIGITAL PLAYFUL ACTIVITIES PROJECTS FOR CHILDREN S TEACHING-LEARNING.” 2018. Web. 09 Dec 2019.

Vancouver:

BRUNNET N. [en] REFLECTIONS ON THE DESIGNER S PRACTICE ON DIGITAL PLAYFUL ACTIVITIES PROJECTS FOR CHILDREN S TEACHING-LEARNING. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2018. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34363.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BRUNNET N. [en] REFLECTIONS ON THE DESIGNER S PRACTICE ON DIGITAL PLAYFUL ACTIVITIES PROJECTS FOR CHILDREN S TEACHING-LEARNING. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2018. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34363

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Pontifical Catholic University of Rio de Janeiro

6. INDIA MARA MARTINS. [en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN.

Degree: 2009, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765

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[pt] O objetivo desta tese é refletir sobre o documentário animado. Um produto audiovisual que mistura documentário e animação e está redefinindo o papel do… (more)

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[pt] O objetivo desta tese é refletir sobre o documentário animado. Um produto audiovisual que mistura documentário e animação e está redefinindo o papel do design na produção das novas mídias. Mostramos também que o documentário animado reacende uma série de debates e reflexões relativas à teoria do documentário e da animação em relação às concepções de realismo. A nossa principal premissa é que o documentário sempre se apropriou da tecnologia de forma a favorecer a experimentação e, o documentário animado, em 3D, é a sua forma de se apropriar das tecnologias digitais. Para comprovar esta hipótese mostramos como a experimentação da tecnologia se deu no documentário em diferentes épocas, mais precisamente nos períodos do primeiro cinema, das vanguardas e da escola britânica – de 1900 a 1930, os anos de 1960, e os anos de 1990 (novas mídias). O que nos interessa é investigar esta relação entre os meios de produção utilizados na realização do documentário – quer tenham esta denominação ou não – e os modos de representação e estilos resultantes da tecnologia de cada época, que pretendemos delinear brevemente. O Design está presente nos dois aspectos: nos meios de produção, por sua tradição ligada ao desenvolvimento de tecnologias e instrumentos para viabilizar a produção, e nos modos de representação, porque as referências estéticas da animação são oriundas das artes gráficas (quadrinhos, ilustrações, etc). Isto também explica, em parte, a ausência da animação na teoria do cinema, aspecto que questionamos, mostrando como a animação está contemplada na teoria Deleuziana. Para concluir, fazemos um estudo de caso de um documentário animado emblemático, por sua abordagem da tecnologia 3D. Ryan (2004), de Chris Landreth, resume o potencial do documentário animado enquanto experimentação da tecnologia, intensidade narrativa e estética não figurativa, em singular referência ao pintor Francis Bacon.

[en] The objective of this thesis is to reflect on the animated documentary. An audiovisual product that mixes both documentary and animation and is redefining the role of the design in the production of new media. We also show that the animated documentary rekindled a series of debates and reflections related to documentary s theory and realism concepts in animation. Our main premise is that the documentary has always appropriated of technology in order to allow experimentation, and the animated documentary, in 3D, is the way to appropriate itself of digital technologies. To prove this hypothesis, we show how the trial of the technology occurred in documentary s history at different times, more precisely during the periods of the early cinema, the vanguards and the British School – from 1900 to 1930, the 1960 s and the 1990 s (new media). What concern us is to investigate this relationship between the means of production used in the making of documentary movies – having this denomination or not – and ways of representation and styles resulting from the technology of each period, which we intend to outline briefly. The Design is…

Advisors/Committee Members: LUIZ ANTONIO LUZIO COELHO.

Subjects/Keywords: [pt] TECNOLOGIA; [en] TECHNOLOGY; [fr] TECHNOLOGIE; [pt] DESIGN; [en] DESIGN; [fr] DESIGN; [pt] EXPERIMENTACAO; [en] EXPERIMENTATION; [fr] EXPERIMENTATION

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

MARTINS, I. M. (2009). [en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

MARTINS, INDIA MARA. “[en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN.” 2009. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

MARTINS, INDIA MARA. “[en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN.” 2009. Web. 09 Dec 2019.

Vancouver:

MARTINS IM. [en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2009. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

MARTINS IM. [en] ANIMATED DOCUMENTARY: EXPERIMENTATION, TECHNOLOGY AND DESIGN. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2009. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13765

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Montréal

7. Salinas Hernandez, Juan Carlos. Synthesis of (S)-cEt-LNA .

Degree: 2014, Université de Montréal

URL: http://hdl.handle.net/1866/11229

Nucleoside (S)-cEt-LNA a été synthétisé par trois voies différentes à partir de la 5- méthyluridine qui est commercialement disponible. Le chemin le plus court comprend une méthylation diastéréosélective d'un aldéhyde, et une cyclisation 5-exo-tet d'un éther par déplacement SN2. Advisors/Committee Members: Hanessian, Stephen (advisor).

Subjects/Keywords: (S)-cEt-LNA; Technologie antisens; Nucleoside; Antisense technology

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APA (6^th Edition):

Salinas Hernandez, J. C. (2014). Synthesis of (S)-cEt-LNA . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/11229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Salinas Hernandez, Juan Carlos. “Synthesis of (S)-cEt-LNA .” 2014. Thesis, Université de Montréal. Accessed December 09, 2019. http://hdl.handle.net/1866/11229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Salinas Hernandez, Juan Carlos. “Synthesis of (S)-cEt-LNA .” 2014. Web. 09 Dec 2019.

Vancouver:

Salinas Hernandez JC. Synthesis of (S)-cEt-LNA . [Internet] [Thesis]. Université de Montréal; 2014. [cited 2019 Dec 09]. Available from: http://hdl.handle.net/1866/11229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Salinas Hernandez JC. Synthesis of (S)-cEt-LNA . [Thesis]. Université de Montréal; 2014. Available from: http://hdl.handle.net/1866/11229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

8. Jireš, Daniel. Renovace pojezdového kola jeřábu navařováním .

Degree: 2016, Brno University of Technology

URL: http://hdl.handle.net/11012/59585

► Diplomová práce řeší návrh volby přídavných materiálů, vhodné technologie a parametrů navařování pro renovaci jeřábového kola. Navrženo bylo celkem pět přídavných materiálů, které byly podrobeny… (more)

Subjects/Keywords: základní materiál; navařování; technologie; S – 4370; basic materials; welding technology; S - 4370

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jireš, D. (2016). Renovace pojezdového kola jeřábu navařováním . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/59585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jireš, Daniel. “Renovace pojezdového kola jeřábu navařováním .” 2016. Thesis, Brno University of Technology. Accessed December 09, 2019. http://hdl.handle.net/11012/59585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jireš, Daniel. “Renovace pojezdového kola jeřábu navařováním .” 2016. Web. 09 Dec 2019.

Vancouver:

Jireš D. Renovace pojezdového kola jeřábu navařováním . [Internet] [Thesis]. Brno University of Technology; 2016. [cited 2019 Dec 09]. Available from: http://hdl.handle.net/11012/59585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jireš D. Renovace pojezdového kola jeřábu navařováním . [Thesis]. Brno University of Technology; 2016. Available from: http://hdl.handle.net/11012/59585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

9. Abu Khait, Yosef. Přetavení povrchu litiny s lupínkovým grafitem a možnosti jeho legování metodou elektronového paprsku .

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/81768

► Tématem diplomové práce jsou strukturní a základní mechanické změny, které probíhají v litině s lupínkovým grafitem po přetavení a legování povrchu prostřednictvím chrom-niklové oceli pomocí… (more)

Subjects/Keywords: Elektronový paprsek; chrom-niklová ocel; EB technologie; litina s lupínkovým grafitem; EN-GJL-300; šedá litina; X2CrNi 19-9; X2CrNi 18-9; Electron beam; chrome nickel steel; EB technology; flake graphite cast iron; EN-GJL-300; grey cast iron; X2CrNi 19-9; X2CrNi 18-9

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abu Khait, Y. (2018). Přetavení povrchu litiny s lupínkovým grafitem a možnosti jeho legování metodou elektronového paprsku . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/81768

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abu Khait, Yosef. “Přetavení povrchu litiny s lupínkovým grafitem a možnosti jeho legování metodou elektronového paprsku .” 2018. Thesis, Brno University of Technology. Accessed December 09, 2019. http://hdl.handle.net/11012/81768.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abu Khait, Yosef. “Přetavení povrchu litiny s lupínkovým grafitem a možnosti jeho legování metodou elektronového paprsku .” 2018. Web. 09 Dec 2019.

Vancouver:

Abu Khait Y. Přetavení povrchu litiny s lupínkovým grafitem a možnosti jeho legování metodou elektronového paprsku . [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2019 Dec 09]. Available from: http://hdl.handle.net/11012/81768.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abu Khait Y. Přetavení povrchu litiny s lupínkovým grafitem a možnosti jeho legování metodou elektronového paprsku . [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/81768

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Saboya, Maria Clara Lopes. Alunas de Engenharia Elétrica e Ciência da Computação: estudar, inventar, resistir.

Degree: PhD, Educação, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/48/48134/tde-15092009-153720/ ;

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Este estudo tem como objetivo analisar como se dá a inserção e a vivência cotidiana de um grupo de mulheres em sala de aula nos… (more)

Subjects/Keywords: ciência e tecnologia (C&T); discriminação; discrimination; ensino superior; gender relations; higher education; preconceito; prejudice; relações de gênero; science and technology (S&T)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saboya, M. C. L. (2009). Alunas de Engenharia Elétrica e Ciência da Computação: estudar, inventar, resistir. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/48/48134/tde-15092009-153720/ ;

Chicago Manual of Style (16^th Edition):

Saboya, Maria Clara Lopes. “Alunas de Engenharia Elétrica e Ciência da Computação: estudar, inventar, resistir.” 2009. Doctoral Dissertation, University of São Paulo. Accessed December 09, 2019. http://www.teses.usp.br/teses/disponiveis/48/48134/tde-15092009-153720/ ;.

MLA Handbook (7^th Edition):

Saboya, Maria Clara Lopes. “Alunas de Engenharia Elétrica e Ciência da Computação: estudar, inventar, resistir.” 2009. Web. 09 Dec 2019.

Vancouver:

Saboya MCL. Alunas de Engenharia Elétrica e Ciência da Computação: estudar, inventar, resistir. [Internet] [Doctoral dissertation]. University of São Paulo; 2009. [cited 2019 Dec 09]. Available from: http://www.teses.usp.br/teses/disponiveis/48/48134/tde-15092009-153720/ ;.

Council of Science Editors:

Saboya MCL. Alunas de Engenharia Elétrica e Ciência da Computação: estudar, inventar, resistir. [Doctoral Dissertation]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/48/48134/tde-15092009-153720/ ;

Pontifical Catholic University of Rio de Janeiro

11. MARIA PAULA SCHMDIT CARVALHO. [en] CARAVANS OF IDENTIFY: A STUDY ABOUT THE RECEPTION OF THE REPRESENTATIONS MADE BY THE SPECIAL REPORTAGE CARAVN JN - IN DEPT ANALYSES OF THE LARGEST REPORTAGE OF BRAZIL AND CLOSE TO THE BRAZILIANS.

Degree: 2009, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13911

►

[pt] Esta pesquisa pertence ao campo das relações entre a cultura de massa e identidade nacional e propõe uma análise de recepção das reportagens produzidas… (more)

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[pt] Esta pesquisa pertence ao campo das relações entre a cultura de massa e identidade nacional e propõe uma análise de recepção das reportagens produzidas pela Caravana do Jornal Nacional, um projeto de telejornalismo executado pela Rede Globo, às vésperas das eleições presidenciais de 2006. Ao percorrer o Brasil de Sul a Norte, a Caravana JN foi ao encontro dos cidadãos que vivem em regiões afastadas dos grandes centros, com o objetivo de levantar os desejos dos brasileiros. Nosso desafio foi reencontrar as pessoas entrevistadas pela equipe de jornalistas, na época, e questioná-las sobre essa experiência de participar de um projeto de telejornalismo e de vivenciar um contato com os profissionais do meio. Vamos avaliar como esses grupos entenderam as representações feitas nas reportagens da Caravana JN, realizadas nas comunidades visitadas, investigar como foi o encontro dos profissionais do JN com o seu próprio público, de que forma as comunidades decodificaram a passagem da Caravana e que tipo de interações sociais o projeto foi capaz de promover. O trabalho de campo foi realizado em duas cidades da região Sul e uma do Sudeste do Brasil. Nossas análises se voltam para as rotinas produtivas do telejornalismo e ao que a Caravana JN significou, em termos de inovação, dentro da trajetória de um produto da comunicação de massa, líder de audiência há quase quatro décadas.

[en] This research belongs to the field of relationship between mass culture and national identity and proposes an assessment on how the special coverage produced by the Caravana do Jornal Nacional was received by the Brazilian communities. Caravana JN was a significant project on broadcast journalism executed by Rede Globo right before the national presidential elections. As it was traveling from south to north of Brazil, the Caravana JN went to the encounter of citizens that live in very remote areas with the objective of investigating what would be their wishes and dreams. One of the challenges of this study was to find the same people that were interviewed by the journalist team then, in order to inquire about the whole experience. More than an evaluation about the representations illustrated on this special coverage of the visited communities, this study also investigates how was the encounter between the television professionals and their audience, in what way the communities decoded the Caravana passage and what kind of social interactions the project was capable to promote. The field part of this research was done in two cities of the South and one of the Southeast regions of Brazil. Our analyses was focused on the production routines of broadcast news in which the Caravana JN made impact in terms of innovation, and on the trajectory of a mass communication product that maintains the highest and record audience ratings of the for more than four decades.

Advisors/Committee Members: LEONEL AZEVEDO DE AGUIAR.

Subjects/Keywords: [pt] TECNOLOGIA; [en] TECHNOLOGY; [en] IDENTITY; [pt] TELEJORNALISMO; [en] TELEVISION NEWS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

CARVALHO, M. P. S. (2009). [en] CARAVANS OF IDENTIFY: A STUDY ABOUT THE RECEPTION OF THE REPRESENTATIONS MADE BY THE SPECIAL REPORTAGE CARAVN JN - IN DEPT ANALYSES OF THE LARGEST REPORTAGE OF BRAZIL AND CLOSE TO THE BRAZILIANS. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13911

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

CARVALHO, MARIA PAULA SCHMDIT. “[en] CARAVANS OF IDENTIFY: A STUDY ABOUT THE RECEPTION OF THE REPRESENTATIONS MADE BY THE SPECIAL REPORTAGE CARAVN JN - IN DEPT ANALYSES OF THE LARGEST REPORTAGE OF BRAZIL AND CLOSE TO THE BRAZILIANS.” 2009. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13911.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

CARVALHO, MARIA PAULA SCHMDIT. “[en] CARAVANS OF IDENTIFY: A STUDY ABOUT THE RECEPTION OF THE REPRESENTATIONS MADE BY THE SPECIAL REPORTAGE CARAVN JN - IN DEPT ANALYSES OF THE LARGEST REPORTAGE OF BRAZIL AND CLOSE TO THE BRAZILIANS.” 2009. Web. 09 Dec 2019.

Vancouver:

CARVALHO MPS. [en] CARAVANS OF IDENTIFY: A STUDY ABOUT THE RECEPTION OF THE REPRESENTATIONS MADE BY THE SPECIAL REPORTAGE CARAVN JN - IN DEPT ANALYSES OF THE LARGEST REPORTAGE OF BRAZIL AND CLOSE TO THE BRAZILIANS. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2009. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13911.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

CARVALHO MPS. [en] CARAVANS OF IDENTIFY: A STUDY ABOUT THE RECEPTION OF THE REPRESENTATIONS MADE BY THE SPECIAL REPORTAGE CARAVN JN - IN DEPT ANALYSES OF THE LARGEST REPORTAGE OF BRAZIL AND CLOSE TO THE BRAZILIANS. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2009. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=13911

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Pontifical Catholic University of Rio de Janeiro

12. MARILENE DA SILVA. [en] THE AUTONOMY IN THE AREA OF ONLINE EDUCATION IN INTERACTIONAL PERSPECTIVE.

Degree: 2017, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31590

►

[pt] Este trabalho apresenta uma análise de possibilidades e limites no que se refere à promoção da autonomia do estudante do Curso de Especialização em… (more)

▼

[pt] Este trabalho apresenta uma análise de possibilidades e limites no que se refere à promoção da autonomia do estudante do Curso de Especialização em Tecnologias em Educação - Lato Sensu (2006-2007), realizado na modalidade a distância, como projeto de parceria entre a Coordenação Central de Educação a Distância (CCEAD/PUC-Rio), o Fundo Nacional de Desenvolvimento da Educação (FNDE), a Secretaria de Educação a Distância (SEED) e o Ministério da Educação e Cultura (MEC). A partir da análise da interface gráfica, dos conteúdos e dos registros documentais hospedados no ambiente virtual, foram investigados indicadores que denotam maior ou menor grau de autonomia dos estudantes no trato com os conteúdos específicos dos componentes curriculares e com a proposta metodológica em si, no que diz respeito à aquisição de conhecimentos. Trazendo uma análise, em linhas gerais, da otimização dos recursos da Internet e sua utilização na aquisição de informações e conhecimentos, o trabalho pretende integrar-se ao conjunto das discussões científicas que vêm sendo realizadas acerca da integração das tecnologias de informação e comunicação na formação de professores. Dessa maneira, visa contribuir para as reflexões sobre as potencialidades telemáticas aplicadas à educação, relacionados à autonomia e à interatividade dos estudantes. A interpretação dos dados, pautada na análise de conteúdo, possibilitou, ainda, a compreensão das especificidades metodológicas das propostas educacionais para o ensino a distância como elemento indicador de favorecimento da autonomia dos estudantes.

[en] This paper presents an analysis of possibilities and limitations with regard to promoting the autonomy of the student of the Curso de Especialização em Tecnologias em Educação - Lato Sensu (2006-2007), carried out in the distance mode, as a partnership project between the Coordenação Central de Educação a Distância (CCEAD/PUC-Rio), the Fundo Nacional de Desenvolvimento da Educação (FNDE), the Secretaria de Educação a Distância (SEED) and the Ministério da Educação e Cultura (MEC). From the analysis of the graphical interface, contents and the documental records hosted on the virtual environment, were investigated indicators which show greater or lesser degree of autonomy of the students in dealing with the specific content of the curriculum components and the proposed methodology in itself, as regards the acquisition of knowledge. Bringing an analysis, in general, of the optimization of the resources of the Internet and its use in the acquisition of information and knowledge, the work seeks to integrate itself to all the scientific discussions being held about the integration of information and communication technologies in teacher education. Thus, it aims to contribute to the reflections about the telematic potentials applied to education, regarding the autonomy and interactivity of the students. The interpretation of data, based on analysis of content, has also the understanding of the specific methodology of educational proposals for distance…

Advisors/Committee Members: ROSALIA MARIA DUARTE.

Subjects/Keywords: [pt] EDUCACAO A DISTANCIA - EAD; [en] DISTANCE EDUCATION; [pt] FORMACAO DE PROFESSORES; [en] TEACHERS FORMATION; [pt] INTERATIVIDADE; [en] INTERACTIVITY; [pt] AUTONOMIA; [en] AUTONOMY; [pt] INTERFACE GRAFICA; [en] GRAPHIC INTERFACE; [pt] TECNOLOGIA EDUCACIONAL; [en] EDUCATIONAL TECHNOLOGY

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

SILVA, M. D. (2017). [en] THE AUTONOMY IN THE AREA OF ONLINE EDUCATION IN INTERACTIONAL PERSPECTIVE. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SILVA, MARILENE DA. “[en] THE AUTONOMY IN THE AREA OF ONLINE EDUCATION IN INTERACTIONAL PERSPECTIVE.” 2017. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SILVA, MARILENE DA. “[en] THE AUTONOMY IN THE AREA OF ONLINE EDUCATION IN INTERACTIONAL PERSPECTIVE.” 2017. Web. 09 Dec 2019.

Vancouver:

SILVA MD. [en] THE AUTONOMY IN THE AREA OF ONLINE EDUCATION IN INTERACTIONAL PERSPECTIVE. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SILVA MD. [en] THE AUTONOMY IN THE AREA OF ONLINE EDUCATION IN INTERACTIONAL PERSPECTIVE. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Pontifical Catholic University of Rio de Janeiro

13. DAIANI DAMM. [en] PEDAGOGICAL PRACTICES AND DIGITAL TECHNOLOGIES IN HIGHER EDUCATION: INITIAL TEACHER TRAINING AND INNOVATION AT FEDERAL UNIVERSITY OF MATO GROSSO DO SUL (UFMS).

Degree: 2018, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=35475

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[pt] O presente estudo teve como foco as práticas pedagógicas com uso de tecnologias digitais nos cursos de licenciatura da Universidade Federal de Mato Grosso… (more)

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[pt] O presente estudo teve como foco as práticas pedagógicas com uso de tecnologias digitais nos cursos de licenciatura da Universidade Federal de Mato Grosso do Sul. O objetivo geral da pesquisa foi identificar e analisar as características das práticas pedagógicas com o uso de tecnologias digitais, sob o ponto de vista dos projetos institucionais e das percepções dos professores e alunos desses cursos, com vistas a identificar o nível de capital tecnológico dos professores e a relação desse capital com as práticas pedagógicas consideradas inovadoras dentro do contexto institucional. O caminho metodológico da pesquisa se iniciou com a revisão de bibliografia, passando pela análise de projetos de curso, aplicação de questionário para os coordenadores, questionário para professores e alunos, finalizando nas entrevistas com professores e alunos. Privilegiamos, nesse estudo, a integração de diferentes procedimentos analíticos com o objetivo de obter um conhecimento descritivo, relacional e compreensivo. A pesquisa indica que, embora existam, na maioria dos projetos pedagógicos, disciplinas que abordem o uso das tecnologias digitais e que os professores usem vários recursos digitais em suas práticas pedagógicas, o nível de incorporação ainda não permite que esse uso ultrapasse o instrumental. As poucas experiências inovadoras encontradas demonstram que o capital tecnológico dos professores é um fator preponderante para as mudanças nas práticas pedagógicas, mas essas experiências isoladas ainda não têm um potencial de difusão e adesão do grupo, pois não há na Instituição um clima favorável à inovação, talvez por não existir um projeto institucional de fomento ao uso de tecnologias digitais na prática pedagógica ou uma política institucional de formação de professores, que estabeleça metas para a melhoria na formação dos professores.

[en] The present study focused on pedagogical practices with the use of digital technologies in undergraduate courses at the Federal University of Mato Grosso do Sul (UFMS). The general objective of the research was to identify and analyze the characteristics of pedagogical practices with the use of digital technologies from the point of view of institutional projects and the perceptions of teachers and students of these courses, in order to identify the level of technological capital of teachers and the relation of this capital to pedagogical practices, considered innovative within the institutional context. The methodological path started with a literature review, through the analysis of course projects, a questionnaire for coordinators and a questionnaire for teachers and students, finalizing with teachers and students interviews. We highlighted on this study the integration of different analytical procedures in order to obtain descriptive, relational and comprehensive knowledge. The research indicates that, although in most pedagogical projects there are disciplines that deal with the use of digital technologies and that teachers use several digital resources in their pedagogical…

Advisors/Committee Members: MAGDA PISCHETOLA.

Subjects/Keywords: [pt] FORMACAO DE PROFESSORES; [en] TEACHERS FORMATION; [pt] ENSINO SUPERIOR; [en] HIGHER EDUCATION; [pt] INOVACAO; [en] INNOVATION; [pt] PRATICAS PEDAGOGICAS; [en] PEDAGOGICAL PRACTICES; [pt] TECNOLOGIA DIGITAL; [en] DIGITAL TECHNOLOGY; [pt] CAPITAL TECNOLOGICO; [en] TECHNOLOGICAL CAPITAL

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DAMM, D. (2018). [en] PEDAGOGICAL PRACTICES AND DIGITAL TECHNOLOGIES IN HIGHER EDUCATION: INITIAL TEACHER TRAINING AND INNOVATION AT FEDERAL UNIVERSITY OF MATO GROSSO DO SUL (UFMS). (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=35475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DAMM, DAIANI. “[en] PEDAGOGICAL PRACTICES AND DIGITAL TECHNOLOGIES IN HIGHER EDUCATION: INITIAL TEACHER TRAINING AND INNOVATION AT FEDERAL UNIVERSITY OF MATO GROSSO DO SUL (UFMS).” 2018. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=35475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DAMM, DAIANI. “[en] PEDAGOGICAL PRACTICES AND DIGITAL TECHNOLOGIES IN HIGHER EDUCATION: INITIAL TEACHER TRAINING AND INNOVATION AT FEDERAL UNIVERSITY OF MATO GROSSO DO SUL (UFMS).” 2018. Web. 09 Dec 2019.

Vancouver:

DAMM D. [en] PEDAGOGICAL PRACTICES AND DIGITAL TECHNOLOGIES IN HIGHER EDUCATION: INITIAL TEACHER TRAINING AND INNOVATION AT FEDERAL UNIVERSITY OF MATO GROSSO DO SUL (UFMS). [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2018. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=35475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DAMM D. [en] PEDAGOGICAL PRACTICES AND DIGITAL TECHNOLOGIES IN HIGHER EDUCATION: INITIAL TEACHER TRAINING AND INNOVATION AT FEDERAL UNIVERSITY OF MATO GROSSO DO SUL (UFMS). [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2018. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=35475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université du Québec à Montréal

14. Motaghi, Hamed. Creativity and technology in the context of creative industries.

Degree: 2015, Université du Québec à Montréal

URL: http://archipel.uqam.ca/8097/1/D2905.pdf

► L'objectif de notre thèse est d'examiner la place qu'occupe la créativité dans les technologies de l'information (TI). Nous présentons dans un premier lieu une discussion… (more)

▼ L'objectif de notre thèse est d'examiner la place qu'occupe la créativité dans les technologies de l'information (TI). Nous présentons dans un premier lieu une discussion des principaux travaux qui ont traité de la créativité dans les systèmes d'information (SI). Ensuite, nous discutons de la relation entre la créativité et la technologie. Cette thèse contient trois articles, et nous présentons ici le contenu de ces articles. Dans le premier article, nous avons effectué une revue de la littérature et nous avons examiné la place de la créativité dans les systèmes d'information et positionné cette recherche à partir de la classification d'Orlikowski et Scott (2008) de la variance, des processus et de la relationalité. Nous avons situé la littérature sur la créativité dans la recherche SI dans une logique de variance et nous avons proposé d'élargir la recherche en étudiant cette relation dans une logique de processus sociaux. Dans le second article, nous nous sommes concentrés sur l'impact des technologies sur la créativité et nous avons mené une étude ethnographique sur un festival à Québec. La contribution de cette article consiste à voir cet impact comme transmissif, interactif et imaginatif. Dans le troisième article, nous nous sommes concentrés sur l'impact de la créativité sur l'utilisation de la technologie et nous avons mené une recherche qualitative dans le secteur de la radio à Montréal. La contribution de cet article est de montrer l'importance de la créativité dans l'usage des systèmes d'information. L'objectif général de cette thèse est d'étendre la connaissance scientifique et pratique en ce qui concerne les SI et la relation entre la créativité et la technologie à partir de la logique du processus social. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : technologies, créativité, processus, acteurs, industries créatives, usage de technologie.

Subjects/Keywords: Créativité; Technologie; Créativité en technologie; Technologie de l'information; Systèmes d'information; Industries culturelles

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Motaghi, H. (2015). Creativity and technology in the context of creative industries. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/8097/1/D2905.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Motaghi, Hamed. “Creativity and technology in the context of creative industries.” 2015. Thesis, Université du Québec à Montréal. Accessed December 09, 2019. http://archipel.uqam.ca/8097/1/D2905.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Motaghi, Hamed. “Creativity and technology in the context of creative industries.” 2015. Web. 09 Dec 2019.

Vancouver:

Motaghi H. Creativity and technology in the context of creative industries. [Internet] [Thesis]. Université du Québec à Montréal; 2015. [cited 2019 Dec 09]. Available from: http://archipel.uqam.ca/8097/1/D2905.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Motaghi H. Creativity and technology in the context of creative industries. [Thesis]. Université du Québec à Montréal; 2015. Available from: http://archipel.uqam.ca/8097/1/D2905.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

15. Santos Oliveira, S. Epidermal growth factor receptor: Target for delivery and silencing.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/32031

► Epidermal growth factor receptor in cancer therapy Recently, cancer research has been able to identify molecular targets that are specific for (or highly expressed by)… (more)

▼ Epidermal growth factor receptor in cancer therapy Recently, cancer research has been able to identify molecular targets that are specific for (or highly expressed by) cancer cells. These molecular targets serve as models for the development of rationally designed anticancer drugs that target important mediators of tumour development. Also, some of these molecular targets have been explored for targeted drug delivery, to ensure that anticancer drugs are specifically delivered to the tumours. The epidermal growth factor receptor (EGFR) is an extensively investigated growth factor and a recognized target for cancer therapy. Many human epithelial cancers overexpress EGFR and the dysregulated EGFR signalling is associated with uncontrolled cell proliferation, inhibition of apoptosis, stimulation of angiogenesis, tissue invasion and metastasis. Two main strategies have been employed to inhibit EGFR: tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs), some of them have already been approved for clinical use. EGFR: target for silencing A different strategy to inhibit EGFR was employed in this thesis. Here, the expression of EGFR protein was interrupted by use of small interfering RNA (siRNA). For efficient gene silencing, siRNA must be delivered intact into the target cell cytoplasm, where RNA interference (RNAi) takes place. Carriers, such as Lipofectamine, are generally used to promote cellular uptake. However, when internalization occurs via endocytosis, the endosomal escape becomes one of the limiting steps for efficient knockdown of the target protein. In this thesis, two different methods were successfully employed to facilitate the endosomal escape of siRNA: an influenza-derived fusogenic peptide and photochemical internalization (PCI). PCI combines a photosensitizer with light to induce photochemical reactions that destabilize endosomal membranes and allow the release of entrapped molecules. PCI was also successfully applied in vivo for enhancing the endosomal escape of anti-EGFR siRNA-Lipofectamine, delivered by intratumoral injection. This study demonstrates that also in vivo endosomal escape is a limiting step that can be facilitated by PCI, improving silencing efficiencies. Local administration of siRNA is not always possible and, therefore, novel targeted drug delivery systems are developed for cancer-specific molecular targets, to direct siRNA and other therapeutic molecules to cancer cells. EGFR: target for delivery Liposomes are attractive delivery systems that have been employed for delivery of a wide range of therapeutic molecules. Liposomes surface has been modified with shielding polymers and targeting ligands that increase their circulation time in the bloodstream and mediate specific target-cell interactions, respectively. In this thesis, a novel targeted drug delivery system was described: anti-EGFR nanobody-liposomes. Nanobodies are the smallest functional antigen binding immunoglobulin fragments that have been isolated from heavy chain-only antibodies, first discovered in camelids.… Advisors/Committee Members: Storm, G, Schiffelers, Raymond.

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos Oliveira, S. (2008). Epidermal growth factor receptor: Target for delivery and silencing. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/32031

Chicago Manual of Style (16^th Edition):

Santos Oliveira, S. “Epidermal growth factor receptor: Target for delivery and silencing.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/32031.

MLA Handbook (7^th Edition):

Santos Oliveira, S. “Epidermal growth factor receptor: Target for delivery and silencing.” 2008. Web. 09 Dec 2019.

Vancouver:

Santos Oliveira S. Epidermal growth factor receptor: Target for delivery and silencing. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/32031.

Council of Science Editors:

Santos Oliveira S. Epidermal growth factor receptor: Target for delivery and silencing. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/32031

Universiteit Utrecht

16. van den Biggelaar, M. Factor VIII trafficking to Weibel-Palade bodies.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/29629

► Summary Factor (F)VIII is an essential cofactor in the enzymatic coagulation cascade. A defect in the gene encoding for FVIII results in the X-linked inherited… (more)

▼ Summary Factor (F)VIII is an essential cofactor in the enzymatic coagulation cascade. A defect in the gene encoding for FVIII results in the X-linked inherited bleeding disorder hemophilia A. In the circulation, FVIII is protected from proteolytic degradation and premature clearance by forming a complex with its carrier protein von Willebrand factor (VWF). While the complex of FVIII and VWF involves one of the strongest protein-protein interactions in the human body, it has remained unclear when and where FVIII and VWF first interact. The most widely accepted view is that FVIII and VWF are secreted from different cells and form a complex in the circulation, merely by virtue of their high-affinity interaction. During the last decade however, increasing evidence has been presented that suggests that the human body should also comprise a releasable storage pool of both proteins. In this thesis, we have studied the relationship between high-affinity interaction in the circulation and intracellular co-storage of FVIII and VWF. We have taken a new approach towards this issue by creating fluorescently tagged VWF and FVIII proteins that are established as being deficient in high-affinity interaction. We have demonstrated that FVIII is stored in VWF-containing storage organelles in absence of high-affinity interaction and that the extent of FVIII storage is independent of its affinity for VWF. In addition, we studied the therapeutic benefit of intracellular co-expression of FVIII and VWF in terms of potential treatment options for hemophilia A. We have shown that blood outgrowth endothelial cells can produce high levels of functional FVIII over a prolonged period of time. In addition, we have demonstrated that a substantial amount of FVIII can be stored in VWF-containing storage organelles whereas the majority of FVIII is released in a constitutive manner. From our data, we conclude that the structural requirements that determine high-affinity interaction between FVIII and VWF in the circulation differ from those that determine intracellular co-trafficking. Our data provide a molecular explanation for the fact that hemophilia A and von Willebrand’s disease patients that suffer from impaired complex assembly of FVIII and VWF in the circulation show concomitant increase of FVIII and VWF plasma levels following treatment with desmopressin. The mechanism that determines FVIII storage in VWF-containing granules as well as the therapeutic potential of FVIII expression in VWF producing cells now awaits further exploration. Advisors/Committee Members: Mertens, Koen, Storm, G, Voorberg, J., Kootstra, N.A..

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

van den Biggelaar, M. (2008). Factor VIII trafficking to Weibel-Palade bodies. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/29629

Chicago Manual of Style (16^th Edition):

van den Biggelaar, M. “Factor VIII trafficking to Weibel-Palade bodies.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/29629.

MLA Handbook (7^th Edition):

van den Biggelaar, M. “Factor VIII trafficking to Weibel-Palade bodies.” 2008. Web. 09 Dec 2019.

Vancouver:

van den Biggelaar M. Factor VIII trafficking to Weibel-Palade bodies. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/29629.

Council of Science Editors:

van den Biggelaar M. Factor VIII trafficking to Weibel-Palade bodies. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/29629

Universiteit Utrecht

17. Oudshoorn, M.H.M. Composite of microgels and lipids as biofilm to restore skin barrier function.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/29883

► The mature epidermis is an effective barrier which prevents the body from dehydration and protects it against various environmental influences. If the natural barrier is… (more)

▼ The mature epidermis is an effective barrier which prevents the body from dehydration and protects it against various environmental influences. If the natural barrier is immature or damaged, the skin barrier is impaired and desiccation occurs. Hence, the regeneration of impaired skin is an essential process for survival. In patients, the natural recovery is sometimes rather slow, in particular in the cases of large defects. To support skin regeneration, a large variety of skin creams is presently available, aiming to modify the hydration level of the skin and to protect the body against excessive water loss and thus to enhance epidermal barrier function. However, these creams clearly have a different structure than stratum corneum (SC), resulting in low water binding capacity and uncontrolled hydration of the skin. The basic mechanism of these skin creams is that they act as moisturizer and increase the hydration of SC by either blocking the TEWL (transepidermal water loss) or by delivering exogenous hygroscopic substances to the SC. Therefore, it has been suggested that the development of barrier creams with high water-holding capacity and thus controlled water transport, such as the natural cream VC (vernix caseosa), might help in the development and/or restoration of the SC barrier. The aim of this thesis was the development of a new generation of skin-surface biofilms, combining the structure and properties of VC, to protect diseased, dry and premature skin and to facilitate wound healing. These biofilms were based on synthetic cells embedded in a lipid matrix. The synthetic cells consisted of crosslinked hydrophilic polymers (hydrogels) with similar size and shape as natural corneocytes. Combined with the work of Rissmann (presented in thesis R. Rissmann), who focused on the development of a synthetic lipid mixture, we were able to prepare biofilms. The biofilms were prepared by mixing the synthetic corneocytes with the lipid matrix. These biofilms were characterized and optimized to mimic VC. Various biofilms were applied topically on disrupted mouse skin to investigate their effect on superficial wound healing. All formulations promoted a rapid formation of SC and prevented epidermal hyperproliferation. In general the synthetic VC analogues showed strong effects concerning the recovery rate, however, only one biofilm mimicked the effects of native VC the most closely. In conclusion, this thesis describes the development of a new generation of skin-surface biofilms mimicking closely the structure and properties of VC. These biofilms act as skin protectants and facilitate the restoration of the SC barrier. These unique systems have therefore great potential to protect diseased, dry and premature skin and to facilitate wound healing in humans. Advisors/Committee Members: Hennink, Wim, Bouwstra, J.A..

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oudshoorn, M. H. M. (2008). Composite of microgels and lipids as biofilm to restore skin barrier function. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/29883

Chicago Manual of Style (16^th Edition):

Oudshoorn, M H M. “Composite of microgels and lipids as biofilm to restore skin barrier function.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/29883.

MLA Handbook (7^th Edition):

Oudshoorn, M H M. “Composite of microgels and lipids as biofilm to restore skin barrier function.” 2008. Web. 09 Dec 2019.

Vancouver:

Oudshoorn MHM. Composite of microgels and lipids as biofilm to restore skin barrier function. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/29883.

Council of Science Editors:

Oudshoorn MHM. Composite of microgels and lipids as biofilm to restore skin barrier function. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/29883

Universiteit Utrecht

18. de Graaf, A.J. Self-assembled materials from thermosensitive and biohybrid block copolymers.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/234839

► In this research, several block copolymers were synthesized and characterized with regard to possible pharmaceutical applications. All block copolymers were thermosensitive and self-assembled at 37… (more)

▼ In this research, several block copolymers were synthesized and characterized with regard to possible pharmaceutical applications. All block copolymers were thermosensitive and self-assembled at 37 °C into structures like micelles and hydrogels, which can be used for innovative drug delivery purposes. Some of the synthesized polymers were biohybrid, in the sense that they contained peptide segments which enabled their cleavage by enzymes that are upregulated in diseased tissues. First, methods were explored for the synthesis of polymer (bio)conjugates. One suitable and popular reaction for synthesizing such conjugates is the copper-catalyzed azide-alkyne cycloaddition ‘click’ reaction. A novel method was developed to introduce a reactive azide functionality on polymers after their synthesis by Atom Transfer Radical Polymerization (ATRP). The newly developed reaction is catalyzed by the ATRP copper catalyst and can be followed by a ‘click’ conjugation reaction using again the same catalyst. Another, relatively new, method to synthesize polymer bioconjugates is to grow a polymer from a peptide or protein. In this research, a peptide containing an enzymatic cleavage site for the tumor-associated matrix metalloproteases (MMPs) 2 and 9 was functionalized at its C-terminus with an ATRP initiator, followed by the polymerization of a hydrophilic polymer block, poly(oligo(ethylene glycol) methyl ether metharcrylate).Then, another ATRP initiator was conjugated to the N-terminus of the peptide followed by the polymerization of a thermosensitive block, poly(N-isopropylacrylamide). At 37 °C in water, all polymers formed micelles with a favorable size for drug delivery purposes. It was shown that the coronas of the micelles could be cleaved off enzymatically. This system may function as a long-circulating drug delivery vehicle with enzyme-triggered destabilization in the target tissue to release e.g. a cytotoxic payload. Subsequently, a study of the physico-chemical differences between ‘star-like’ micelles and ‘flower-like micelles’ was performed. Star-like micelles are formed from amphiphilic diblock copolymers, whereas flower-like micelles are formed from triblock copolymers that consist of two hydrophobic blocks separated by a hydrophilic block. Both Static Light Scattering and 1H NMR T2 relaxation measurements indicated that hydrophilic polymer blocks in flower-like micelles are less flexible than in star-like micelles. The last part of this research focused on a particular property of flower-like micelles, namely the fact that at high concentration they are in equilibrium with a hydrogel. When a thermosensitive triblock copolymer hydrogel was brought into water, flower-like micelles were released. When the hydrogel was pre-loaded with the cytostatic drug paclitaxel, this was co-released with the micelles. The system was tested in a tumor xenograft mouse model: paclitaxel-loaded hydrogels were injected i.p., after which paclitaxel was slowly released and could be measured in the circulation for two days. Furthermore, the… Advisors/Committee Members: Hennink, Wim, Mastrobattista, Enrico, Vermonden, Tina.

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

de Graaf, A. J. (2012). Self-assembled materials from thermosensitive and biohybrid block copolymers. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/234839

Chicago Manual of Style (16^th Edition):

de Graaf, A J. “Self-assembled materials from thermosensitive and biohybrid block copolymers.” 2012. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/234839.

MLA Handbook (7^th Edition):

de Graaf, A J. “Self-assembled materials from thermosensitive and biohybrid block copolymers.” 2012. Web. 09 Dec 2019.

Vancouver:

de Graaf AJ. Self-assembled materials from thermosensitive and biohybrid block copolymers. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2012. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/234839.

Council of Science Editors:

de Graaf AJ. Self-assembled materials from thermosensitive and biohybrid block copolymers. [Doctoral Dissertation]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/234839

Universiteit Utrecht

19. Filipe, V.L.S. Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/240480

► Therapeutic proteins have become invaluable in treating a wide range of serious and life-threatening diseases. However, repeated administration of these drugs to patients often induces… (more)

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Filipe, V. L. S. (2012). Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/240480

Chicago Manual of Style (16^th Edition):

Filipe, V L S. “Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity.” 2012. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/240480.

MLA Handbook (7^th Edition):

Filipe, V L S. “Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity.” 2012. Web. 09 Dec 2019.

Vancouver:

Filipe VLS. Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2012. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/240480.

Council of Science Editors:

Filipe VLS. Monoclonal antibody aggregates: physicochemical characteristics, stability in biological fluids and immunogenicity. [Doctoral Dissertation]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/240480

Universiteit Utrecht

20. Stavenuiter, F. Factor seven activating protease : in search of a physiological role.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/179070

► Since its discovery in 1996, numerous functions have been proposed for Factor VII-activating protease (FSAP) including interactions with the haemostatic system. These include activation of… (more)

Subjects/Keywords: Farmacie; Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stavenuiter, F. (2010). Factor seven activating protease : in search of a physiological role. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/179070

Chicago Manual of Style (16^th Edition):

Stavenuiter, F. “Factor seven activating protease : in search of a physiological role.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/179070.

MLA Handbook (7^th Edition):

Stavenuiter, F. “Factor seven activating protease : in search of a physiological role.” 2010. Web. 09 Dec 2019.

Vancouver:

Stavenuiter F. Factor seven activating protease : in search of a physiological role. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/179070.

Council of Science Editors:

Stavenuiter F. Factor seven activating protease : in search of a physiological role. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/179070

Universiteit Utrecht

21. van Gaal, E.V.B. DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/180021

► The aim of gene therapy is to treat, cure or prevent a disease by replacing defective genes, introducing new genes or changing the expression of… (more)

▼ The aim of gene therapy is to treat, cure or prevent a disease by replacing defective genes, introducing new genes or changing the expression of a person’s genes. Success of gene therapy is dependent on successful delivery of DNA from the site of administration into cell nuclei. Naturally occurring and highly efficient gene delivery systems are viruses. However, issues of safety, limited targeting possibilities and limited loading capacity justify the search for safe and flexible synthetic (non-viral) alternatives. Despite numerous efforts, success of non-viral gene delivery is hampered due to four major problems: toxicity, short-lived expression, heterogeneity of expression and low efficiency. The aim of this thesis is to rationally design DNA-Transporting Nanoparticles (DTN), focusing on three levels: (1) design of DNA to increase safety, efficiency and duration of transgene expression, (2) design of formulations to increase efficiency of transfection and (3) development of methods to allow better analysis of DTN. First it is shown how rational design of plasmid DNA can increase safety, efficiency and duration of transgene expression. Next, two strategies to improve nuclear uptake of DTN are examined. The first strategy involves modification of plasmid with DNA nuclear Targeting Sequences (DTS) which would facilitate nuclear localization by inducing coating of plasmid DNA with nuclear localization signals (NLS)-containing proteins and subsequent binding to importins. Modification of plasmids with DTS was not shown to increase gene expression, regardless of the cell line, dose and carrier system chosen, indicating that a bottleneck exists downstream of nuclear delivery. The second strategy was based on the non-covalent coupling of NLS-peptides to DNA. Peptides were shown to enhance transfection efficiency, but in an NLS-independent way. Next, the number of plasmids per DTN is addressed. The amount of active DNA could be reduced substantially while maintaining transfection activity by replacing active DNA with non-coding junk DNA. The results indicate that not the total amount of DNA, but the number of active DNA-containing particles is the critical factor in determining transfection efficiency. Size of DTN is a critical parameter, but preparation of DTN generally yields heterogeneously sized populations. Additionally, the size of DTN is affected by exposure to salts and proteins. A new method based on flow cytometry was developed to measure particle size distributions directly in biological fluids. Simultaneous detection of fluorescence and side scattering intensity (SSC ; indicative of size) provided the possibility to distinguish fluorescently labeled nanoparticles of interest from other particulate matter frequently present in biological fluid. Additionally, a proof of principle to sort heterogeneous populations into different size fractions was obtained. Testing of new gene delivery reagents is usually performed by reading out transgene expression levels relative to a reference formulation after in vitro… Advisors/Committee Members: Crommelin, Daniel, Hennink, Wim, Mastrobattista, Enrico, Oosting, Ronald.

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

van Gaal, E. V. B. (2010). DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/180021

Chicago Manual of Style (16^th Edition):

van Gaal, E V B. “DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/180021.

MLA Handbook (7^th Edition):

van Gaal, E V B. “DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery.” 2010. Web. 09 Dec 2019.

Vancouver:

van Gaal EVB. DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/180021.

Council of Science Editors:

van Gaal EVB. DNA-transporting nanoparticles : design and in vitro evaluation of DNA and formulation for non-viral gene delivery. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/180021

Universiteit Utrecht

22. Censi, R. Temperature sensitive hydrogels for protein delivery and tissue engineering.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/187371

► Hydrogels are water-swollen polymeric materials able to maintain a distinct three-dimensional structure. They were the first biomaterials designed for clinical use in the early 1950s,… (more)

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA (6^th Edition):

Censi, R. (2010). Temperature sensitive hydrogels for protein delivery and tissue engineering. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/187371

Chicago Manual of Style (16^th Edition):

Censi, R. “Temperature sensitive hydrogels for protein delivery and tissue engineering.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/187371.

MLA Handbook (7^th Edition):

Censi, R. “Temperature sensitive hydrogels for protein delivery and tissue engineering.” 2010. Web. 09 Dec 2019.

Vancouver:

Censi R. Temperature sensitive hydrogels for protein delivery and tissue engineering. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/187371.

Council of Science Editors:

Censi R. Temperature sensitive hydrogels for protein delivery and tissue engineering. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/187371

Universiteit Utrecht

23. Sauerborn, M.S. Immunological aspects of antibody formation against recombinant human therapeutics.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/188116

► With about 200 new products in the pipeline, recombinant human (rh) therapeutics are becoming the most dominant class of drugs. One of the reasons to… (more)

▼ With about 200 new products in the pipeline, recombinant human (rh) therapeutics are becoming the most dominant class of drugs. One of the reasons to create rh therapeutics was to avoid recognition by the immune system due to foreign origin. Nevertheless, rh therapeutics induced formation of anti-drug antibodies. Aggregation of the therapeutic protein became a major concern, directing the focus on an ancient mechanism of the immune system to recognize repetitive epitopes on pathogens and activation of a non-classical T-cell – B-cell pathway leading to a fast and efficient immune response. It was hypothesized that aggregated rh therapeutics mimic such repetitive epitope carrying pathogens, named T cell independent type 2 antigens. The thesis entitles ‘Immunological aspects of antibody formation against recombinant human therapeutics’ investigated the immunological mechanisms triggered after administration of aggregated rh therapeutics in transgenic mice immune tolerant for the therapeutic of interest. A three step approach was used: (I) Memory formation after administration of aggregated rh therapeutics?, (II) Is the response T cell independent?, (III) Do Marginal Zone B cells influence the immune response against rh therapeutics?. Two model therapeutics were used: (1) rh interferon beta, and (2) recombinant human interferon alpha. Both models showed the absence of memory formation after initial challenge and boost with both aggregated and non-aggregated rh drugs. In addition, a lack of neutralizing antibodies was observed. Though memory was absent, animals had an abundant pool of isotype switched antibodies, a sign for T cell dependency. And indeed, depletion of CD4+ T cells led to a complete abolishment of the antibody formation against aggregated therapeutic. Lastly, it could be shown that the depletion of marginal zone B cells influence the response against rh therapeutics. In conclusions, it was shown that the immune response directed against aggregated rh therapeutics is neither comparable to a classical nor to a T cell independent type 2 antigen. In addition, the presence of naturally occurring antibodies in human blood samples was investigated. It is hypothesized that patients having natural occurring antibodies against a rh therapeutic may be more susceptible to formation of anti-drug antibodies when treated with the rh therapeutic. The presence of naturally occurring antibodies against interferon alpha, beta and gamma and bone morphogenetic proteins 2 and 7 could be found in around 2% of individuals (n=400). Their influence on the immunogenicity of rh therapeutics need to be further explored. Advisors/Committee Members: Schellekens, Huub, Jiskoot, W..

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sauerborn, M. S. (2010). Immunological aspects of antibody formation against recombinant human therapeutics. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/188116

Chicago Manual of Style (16^th Edition):

Sauerborn, M S. “Immunological aspects of antibody formation against recombinant human therapeutics.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/188116.

MLA Handbook (7^th Edition):

Sauerborn, M S. “Immunological aspects of antibody formation against recombinant human therapeutics.” 2010. Web. 09 Dec 2019.

Vancouver:

Sauerborn MS. Immunological aspects of antibody formation against recombinant human therapeutics. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/188116.

Council of Science Editors:

Sauerborn MS. Immunological aspects of antibody formation against recombinant human therapeutics. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/188116

Universiteit Utrecht

24. Schillemans, J.P. Charged hydrogels for post-loading, release, and molecular imprinting of proteins.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/188112

► Molecular imprinting is a technique to create template-shaped cavities in polymer matrices with memory of the template molecules, to be used in molecular recognition. Molecular… (more)

▼ Molecular imprinting is a technique to create template-shaped cavities in polymer matrices with memory of the template molecules, to be used in molecular recognition. Molecular imprinting of low molecular weight compounds is a well established technique used to create high affinity materials. On the other hand, molecular imprinting of high molecular weight compounds such as proteins is not nearly as successful for various reasons. Nevertheless, the use of hydrogels has led to some encouraging protein imprinting results. A hydrogel consists of a three dimensional polymer network that is able to retain large amounts of water with conservation of the network structure. As a result of the high water content, hydrogels are generally considered as biocompatible materials, which makes them particularly interesting for biomedical and pharmaceutical applications. In this thesis, an innovative method to prepare hydrogel nanoparticles with protein imprints on their surface is proposed. Polyacrylamide nanoparticles were prepared inside the internal aqueous compartment of liposomes, prepared by detergent removal. Macroscopic hydrogel formation due to polymerization of the monomers outside the liposomes was prevented by inhibition of free-radical polymerization of non-encapsulated monomers by addition of ascorbic acid. This method offers straightforward control over the shape and size of the particles. Moreover, the liposomal bilayer offers the possibility to incorporate membrane proteins, which can then be used as templates for surface imprinting. It is shown that SN/GpA is successfully incorporated in the liposomal bilayer. Importantly, the hydrophilic domain of SN/GpA was oriented towards the internal compartment of the liposome, and therefore would be available for the formation of imprints. However, despite many attempts towards the synthesis of PINAPLES, a proof of concept was not obtained. This is partially due to the current state of the art of protein imprinting. Protein imprinting is still a relatively new scientific field. Although the number of research papers that describe protein imprinting is increasing, the actual scientific proof of the feasibility of selective recognition of proteins by molecular imprinted polymers in aqueous environment is not convincing. Electrostatic interaction between protein and hydrogel network can cause high aspecific binding, and may therefore not be suited for molecular imprinting. However, this strong interaction may be useful as a tool for controlled release of therapeutic proteins from pharmaceutical formulations. Charged hydrogels were obtained by copolymerization of methacrylated dextran (Dex-MA) with either methacrylic acid (MA) or 2-N,N-dimethylaminoethyl methacrylate (DMAEMA). The effect of incorporation of the charged monomers on hydrogel charge, equilibrium swelling and release of model proteins was assessed both at low (10 mM HEPES) and physiological ionic strength (HEPES buffered saline, HBS). It was concluded that incorporation of charge in a hydrogel network can be used… Advisors/Committee Members: Hennink, Wim, van Nostrum, Rene.

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schillemans, J. P. (2010). Charged hydrogels for post-loading, release, and molecular imprinting of proteins. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/188112

Chicago Manual of Style (16^th Edition):

Schillemans, J P. “Charged hydrogels for post-loading, release, and molecular imprinting of proteins.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/188112.

MLA Handbook (7^th Edition):

Schillemans, J P. “Charged hydrogels for post-loading, release, and molecular imprinting of proteins.” 2010. Web. 09 Dec 2019.

Vancouver:

Schillemans JP. Charged hydrogels for post-loading, release, and molecular imprinting of proteins. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/188112.

Council of Science Editors:

Schillemans JP. Charged hydrogels for post-loading, release, and molecular imprinting of proteins. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/188112

Universiteit Utrecht

25. Crielaard, B.J. Targeted nanomedicines for the treatment of inflammatory disorders and cancer.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/227848

► The therapeutic value of various targeted nanomedicines was evaluated in several inflammatory disorders, including cancer, while exploring which nanocarrier may be most suitable for a… (more)

▼ The therapeutic value of various targeted nanomedicines was evaluated in several inflammatory disorders, including cancer, while exploring which nanocarrier may be most suitable for a specific therapeutic application. First, an overview of drug targeting systems presently available for anti-inflammatory therapy was given. Then, the thesis fell apart in three sections: two sections diverging the therapeutic scope of several novel and established targeted nanomedicines to various inflammatory diseases and cancer, and a final section to bring these and other efforts together in the quest for the ‘optimal’ nanomedicine for a given application. The first section dealt with the preclinical evaluation of targeted dexamethasone-containing carriers in three different models of inflammatory disease. On the one hand, the therapeutic activity of dexamethasone encapsulated into the aqueous core of long-circulating liposomes was studied in mice with experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), as well as in mice with dextran sodium sulfate (DSS)-induced colitis, a model for inflammatory bowel disease (IBD). Interestingly, the targeted delivery of dexamethasone using long-circulating liposomes was therapeutically efficacious in preclinical models of RA and MS, but not in IBD. On the other hand, a dexamethasone-delivery system based on core-crosslinked polymeric micelles demonstrated strong therapeutic efficacy in two preclinical models of rheumatoid arthritis (RA). The second section focused on the development of new nanomedicines derived from colchicine with vascular disrupting activity. The synthesis, liposomal encapsulation and in vitro characterization of two polymeric prodrugs of colchicine were described, and one of these prodrugs was selected for preclinical evaluation in tumor-bearing mice, to demonstrate a highly efficacious in vivo vascular disrupting activity of this new type of colchicine-derivatives. As part of the third and last section, which addressed the application-oriented search for an optimal nanocarrier system for drug targeting, three different nanocarriers of dexamethasone were evaluated in a comparative study to assess their therapeutic efficacy in two animal models of RA, providing deeper insights in the therapeutic efficacy of each of the systems. Then, to allow for the screening of different nanomedicines without requiring extensive usage of laboratory animals, an in vitro assay for predicting the in vivo circulation kinetics of liposomes was presented. Finally, the thesis concludes with a summarizing discussion regarding the findings presented in this thesis Advisors/Committee Members: Storm, G, Hennink, Wim, Schiffelers, Raymond, Lammers, Twan.

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Crielaard, B. J. (2012). Targeted nanomedicines for the treatment of inflammatory disorders and cancer. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/227848

Chicago Manual of Style (16^th Edition):

Crielaard, B J. “Targeted nanomedicines for the treatment of inflammatory disorders and cancer.” 2012. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/227848.

MLA Handbook (7^th Edition):

Crielaard, B J. “Targeted nanomedicines for the treatment of inflammatory disorders and cancer.” 2012. Web. 09 Dec 2019.

Vancouver:

Crielaard BJ. Targeted nanomedicines for the treatment of inflammatory disorders and cancer. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2012. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/227848.

Council of Science Editors:

Crielaard BJ. Targeted nanomedicines for the treatment of inflammatory disorders and cancer. [Doctoral Dissertation]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/227848

Universiteit Utrecht

26. Verheul, R.J. Tailorable Trimethyl chitosans as adjuvant for intranasal immunization.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/186880

► Tailorable Trimethyl Chitosans as Adjuvant for Intranasal Immunization Active vaccination has proven to be the most (cost) effective tool in the fight against infectious diseases.… (more)

▼ Tailorable Trimethyl Chitosans as Adjuvant for Intranasal Immunization Active vaccination has proven to be the most (cost) effective tool in the fight against infectious diseases. Nowadays, most vaccines are administered via parenteral injection. However, the risk of contaminated needles and need for trained personnel have risen interest in alternative immunization routes. As live attenuated vaccines raise considerable safety issues, (nasal) vaccine development now mainly focuses on purified, well-characterized antigenic proteins. However, these subunit vaccines are generally less immunogenic and need potent adjuvant (system)s to elicit an adequate immune response. The use of muco-adhesive polymers like N,N,N-trimethylchitosan (TMC), a partially quaternized, water-soluble chitosan derivative, can enhance the immune responses against antigens. In this thesis novel synthetic methods are presented to obtain structural variants of TMC that allow tailorability of the degrees of quaternization (DQ) and acetylation (DAc) and exclude the introduction of other alterations such as O-methylation (DOM)and polymer chain scission. Additionally, thiol-moieties are introduced in a controllable manner to yield thiolated TMC. This tailorability of TMC provided the possibility to properly establish structure-activity-relationships in in vitro biological assays and in in vivo (nasal) vaccination studies. On Caco-2, cells O-methyl free TMCs demonstrated a larger decrease in trans-epithelial electrical resistance (TEER) than O-methylated TMCs while TMCs with a high DAc (~50%), were not able to open tight junctions. Also, with increasing DQ, an increase in cytotoxicity (MTT) and membrane permeability (LDH) was observed. On the other hand, TMCs with a high DAc (~50%) demonstrated no cell toxicity (MTT, LDH release) up to a concentration of 10 mg/ml. The extent of lysozyme-catalyzed degradation of TMC was highly dependent on the DAc; polymers with the highest DAc showed the largest decrease in molecular weight. Using Calu-3 cells, XTT and LDH cell viability tests showed a slight reduction in cytotoxicity for thiolated TMCs as compared to the non-thiolated polymers with similar DQs. The adjuvant properties of TMCs as nasal adjuvant in mice, using whole inactivated influenza virus as antigen, were strongly decreased by re-acetylation of TMC, whereas the DQ and DOM hardly affected the adjuvanticity of TMC. The inferior adjuvant effect of TMC-RA over that of TMC might be caused by a slightly lower stability of TMC-RA in the nasal cavity. In vitro experiments with human and murine dendritic cells indicated that the degree of N-acetylation is critical for the adjuvant effect of TMC on human DCs, but not on mice DCs. Finally, a covalently-stabilized polymeric nanocarrier system was introduced based upon the formation of intracellularly degradable disulfides between thiolated TMC (TMC-SH) and (oppositely charged) thiolated hyaluronic acid (HA-SH). Stabilized TMC-S-S-HA nanoparticles showed superior stability in saline solutions compared to… Advisors/Committee Members: Hennink, Wim, Jiskoot, W..

Subjects/Keywords: Medical technology; Farmacie(FARM); Biomedische technologie en medicijnen; Pharmacology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Verheul, R. J. (2010). Tailorable Trimethyl chitosans as adjuvant for intranasal immunization. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/186880

Chicago Manual of Style (16^th Edition):

Verheul, R J. “Tailorable Trimethyl chitosans as adjuvant for intranasal immunization.” 2010. Doctoral Dissertation, Universiteit Utrecht. Accessed December 09, 2019. http://dspace.library.uu.nl:8080/handle/1874/186880.

MLA Handbook (7^th Edition):

Verheul, R J. “Tailorable Trimethyl chitosans as adjuvant for intranasal immunization.” 2010. Web. 09 Dec 2019.

Vancouver:

Verheul RJ. Tailorable Trimethyl chitosans as adjuvant for intranasal immunization. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2010. [cited 2019 Dec 09]. Available from: http://dspace.library.uu.nl:8080/handle/1874/186880.

Council of Science Editors:

Verheul RJ. Tailorable Trimethyl chitosans as adjuvant for intranasal immunization. [Doctoral Dissertation]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/186880

Pontifical Catholic University of Rio de Janeiro

27. EUNICE DE CASTRO E SILVA. [en] LEARNERS CONCEPTION ON ONLINE TUTORING: A DISTANCE LEARNING COURSE CASE STUDY.

Degree: 2016, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=28285

►

[pt] A educação na modalidade a distância tem sido apontada como uma estratégia eficiente para a formação inicial e continuada de professores para a educação… (more)

▼

[pt] A educação na modalidade a distância tem sido apontada como uma estratégia eficiente para a formação inicial e continuada de professores para a educação básica. Contudo, a expansão dessa modalidade também vem acompanhada de críticas e preocupações quanto à qualidade dessa formação. Uma das problemáticas principais da EAD reside na mediação pedagógica, em relação à díade aluno–mediador e/ou professor. Nesse sentido, esse trabalho teve como objetivo investigar a concepção dos alunos de um curso de especialização na modalidade a distância sobre a mediação pedagógica, partindo das seguintes questões de estudo: Quais atribuições os alunos delegam à mediação pedagógica? Quais as contribuições da mediação pedagógica para a qualidade da formação dos cursistas? Como as tecnologias da comunicação e informação (TIC) potencializam a mediação pedagógica? A fim de compreender o conceito de mediação, procuramos fazer uma pesquisa desse termo em campos interdisciplinares, relacionando-o com os avanços das TICs na educação a distância. Optamos, metodologicamente, por um estudo de caso do Curso de Especialização Tecnologias em Educação – PUC Rio. Para a produção de dados fizemos um recorte das respostas dos cursistas sobre a mediação pedagógica exercida no decorrer do curso, após aplicação de um questionário. As questões fechadas foram analisadas com a ajuda do programa SPSS, e selecionou-se uma questão aberta que foi trabalhada através da análise de conteúdo, utilizando-se o programa Alceste. Os resultados provenientes das questões fechadas mostraram uma grande aceitabilidade da atuação do mediador pedagógico. Na análise qualitativa, o software Alceste originou quatro classes, sendo posteriormente identificadas como: estratégias pedagógicas de mediação e mediador assistente; mediador tira-dúvidas; motivação ao aluno; formação do mediador pedagógico e influências da mediação na atuação profissional do aluno. As concepções dos cursistas revelaram o reconhecimento e a valorização da mediação como essencial para que o aluno construa o conhecimento esperado no processo de aprendizagem. Ficou evidenciada a complexidade da prática profissional do mediador tendo, inclusive, influência na formação e atuação profissional do cursista.

[en] Distance learning has been identified as an effective strategy for initial and continuing teacher training in the primary and secondary education sector. However, expansion in this field has also been followed by criticisms and concerns about the quality of such training. One of the main issues in distance learning is online tutoring, more specifically learner-tutor and/or learner-teacher interaction. Therefore, the objective of the present study was to investigate learners conception on online tutoring in a distance learning specialization course. Our main research study questions were: What do learners expect from their online tutors? Which contributions does online tutoring offer to the quality of learners training? How can ICT enhance the online tutoring practice? In order to understand the…

Advisors/Committee Members: GILDA HELENA BERNARDINO DE CAMPOS, GILDA HELENA BERNARDINO DE CAMPOS.

Subjects/Keywords: [pt] EDUCACAO A DISTANCIA - EAD; [en] DISTANCE EDUCATION; [pt] ANALISE DE CONTEUDO; [en] CONTENT ANALYSIS; [pt] MEDIACAO PEDAGOGICA; [en] EDUCATIONAL MEDIATION; [pt] TECNOLOGIA DA INFORMACAO E COMUNICACAO - TIC; [en] INFORMATION AND COMMUNICATION TECHNOLOGY - ICT; [pt] SOFTWARE ALCESTE; [en] ALCESTE SOFTWARE

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

SILVA, E. D. C. E. (2016). [en] LEARNERS CONCEPTION ON ONLINE TUTORING: A DISTANCE LEARNING COURSE CASE STUDY. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=28285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SILVA, EUNICE DE CASTRO E. “[en] LEARNERS CONCEPTION ON ONLINE TUTORING: A DISTANCE LEARNING COURSE CASE STUDY.” 2016. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=28285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SILVA, EUNICE DE CASTRO E. “[en] LEARNERS CONCEPTION ON ONLINE TUTORING: A DISTANCE LEARNING COURSE CASE STUDY.” 2016. Web. 09 Dec 2019.

Vancouver:

SILVA EDCE. [en] LEARNERS CONCEPTION ON ONLINE TUTORING: A DISTANCE LEARNING COURSE CASE STUDY. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2016. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=28285.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SILVA EDCE. [en] LEARNERS CONCEPTION ON ONLINE TUTORING: A DISTANCE LEARNING COURSE CASE STUDY. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2016. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=28285

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Pontifical Catholic University of Rio de Janeiro

28. MARIO RICARDO DA SILVA LIMA. [en] 3D TECHNOLOGIES EXPERIMENTATION BY STUDENTS IN THE KINDERGARTEN IN THE CITY OF RIO DE JANEIRO.

Degree: 2017, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30695

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[pt] As tecnologias 3D estão se consolidando em espaços profissionais e, entre suas possibilidades de uso, está seu emprego no contexto educacional. As pesquisas para… (more)

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[pt] As tecnologias 3D estão se consolidando em espaços profissionais e, entre suas possibilidades de uso, está seu emprego no contexto educacional. As pesquisas para desenvolvimento de tecnologias partem de um referencial ainda distante da realidade educacional e com predominância de visões advindas do público adulto. Nesse sentido, há espaço para o entendimento de como as crianças experimentam tais tecnologias - impressão 3D (manufatura aditiva), modelagem 3D e escaneamento 3D - no ambiente escolar da Educação Infantil. A presente pesquisa busca investigar qual a contribuição da experimentação das tecnologias 3D para a Educação Infantil, objetivando abrir possibilidades para o entendimento das formas de experimentação pelos alunos. A partir da leitura de documentos governamentais e de teóricos da educação e do desenvolvimento infantil, além do levantamento de outras experiências semelhantes, foi estruturado um experimento composto por três encontros, baseados no método de pesquisa-ação. O primeiro encontro ocorreu no espaço não formal do museu - para apresentação das tecnologias - e os outros dois no ambiente de sala de aula - para a experimentação e reflexão sobre as tecnologias. Para o experimento, foram selecionadas três turmas do último ano da Educação Infantil da escola Curiosa Idade, além do Museu Internacional de Arte Naif. Para a análise dos dados obtidos, foi utilizada a abordagem da Sociolinguística Interacional. Foi constatado que os alunos do último ano da Educação Infantil são capazes de compreender todo o processo, do escaneamento 3D de objetos, passando pela customização via modelagem 3D e chegando ao objeto modificado impresso em 3D. Além disso, verificou-se que a ludicidade e a criatividade são potencializadas pelo uso das tecnologias 3D.

[en] The 3D technologies are ever more present in professional spaces, and among their possibilities is their employment in the educational context. The research for technologies development starts from a referential still far from the educational reality and with visions coming predominatly from the perspective of adults. In this sense, there is room for understanding how children experience such technologies - 3D printing (additive manufacturing), 3D modeling and 3D scanning - in the preschool environment of Educação Infantil (brazilian stage similar to the Early Childhood Education). The present research seeks to investigate the contribution of the 3D technologies experimentation to Educação Infantil, aiming to open possibilities for the understanding of the ways of experimentation by the students. Having reviewed governmental documents and education and child development theorists, besides surveying similar experiences, an experiment was structured consisting of three meetings, based on the action-research method. The first meeting took place in the museum s non-formal space - for the presentation of technologies - and the other two in the classroom environment - for experimentation and reflection on technologies. For the experiment, three groups attending…

Advisors/Committee Members: JORGE ROBERTO LOPES DOS SANTOS.

Subjects/Keywords: [pt] EDUCACAO INFANTIL; [en] EARLY CHILDHOOD EDUCATION; [pt] MEDIACAO; [en] MEDIATION; [pt] DESIGN E TECNOLOGIA; [en] DESIGN AND TECHNOLOGY; [pt] TECNOLOGIAS 3D; [en] 3D TECHNOLOGIES; [pt] EXPERIMENTACAO 3D; [en] 3D EXPERIMENTATION

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

LIMA, M. R. D. S. (2017). [en] 3D TECHNOLOGIES EXPERIMENTATION BY STUDENTS IN THE KINDERGARTEN IN THE CITY OF RIO DE JANEIRO. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30695

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

LIMA, MARIO RICARDO DA SILVA. “[en] 3D TECHNOLOGIES EXPERIMENTATION BY STUDENTS IN THE KINDERGARTEN IN THE CITY OF RIO DE JANEIRO.” 2017. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30695.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

LIMA, MARIO RICARDO DA SILVA. “[en] 3D TECHNOLOGIES EXPERIMENTATION BY STUDENTS IN THE KINDERGARTEN IN THE CITY OF RIO DE JANEIRO.” 2017. Web. 09 Dec 2019.

Vancouver:

LIMA MRDS. [en] 3D TECHNOLOGIES EXPERIMENTATION BY STUDENTS IN THE KINDERGARTEN IN THE CITY OF RIO DE JANEIRO. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30695.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

LIMA MRDS. [en] 3D TECHNOLOGIES EXPERIMENTATION BY STUDENTS IN THE KINDERGARTEN IN THE CITY OF RIO DE JANEIRO. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30695

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Pontifical Catholic University of Rio de Janeiro

29. ALINE DE MENDONÇA BRASILINO. [en] TEACHERS TRAINING AND EDUCATIONAL PRACTICE WITH TECHNOLOGIES: A CORRELATIONAL STUDY ON THE TIC EDUCAÇÃO 2014 DATA BASIS.

Degree: 2017, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31998

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[pt] Momentos de formação continuada para o uso pedagógico das Tecnologias da Informação e Comunicação (TIC) têm por objetivo promover a integração do uso das… (more)

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[pt] Momentos de formação continuada para o uso pedagógico das Tecnologias da Informação e Comunicação (TIC) têm por objetivo promover a integração do uso das TIC nas práticas pedagógicas. Com o intuito de contribuir para a análise dos resultados alcançados por esses momentos de formação, este trabalho estudou a relação entre a participação do professor nesses momentos e as suas práticas com TIC. Investigamos a presença das tecnologias nos momentos de formação e analisamos as políticas públicas de disseminação das TIC nas escolas. Paralelamente, realizamos uma pesquisa quantitativa com o objetivo de estudar a correlação entre as variáveis latentes formação específica em TIC e uso pedagógico de TIC pelos professores com os dados da TIC Educação 2014. Para atribuirmos uma medida a essas variáveis latentes, construímos quatro escalas utilizando a Teoria de Resposta ao Item (TRI). Duas escalas de formação, uma que considera os momentos institucionalizados e outra os informais dos quais os professores participaram; e duas escalas de uso, uma considerando as atividades com os alunos e outra as ações de preparação de aula. Para explicar a variável dependente uso pedagógico de TIC, construímos um modelo de regressão linear considerando como variáveis explicativas: as variáveis de formação específica em TIC e as variáveis de controle. Os resultados principais indicam que o uso pedagógico de TIC (Atividade e Preparação) é influenciado positivamente pela formação específica em TIC Institucionalizada e Informal, disciplina específica em TIC na graduação, renda mensal familiar e titulação, negativamente pela idade, e não é influenciado por curso específico em TIC, sexo e cor/raça.

[en] Moments of professional training for the pedagogical use of information and communication technologies (ICT) aim to promote the integration of the use of ICT in pedagogical practices. In order to contribute to the analysis of results achieved by these training moments, this dissertation presents a study on the relationship between teacher s participation in these moments and his practices with ICT. We investigate the presence of technology in formation and we analyzed public policies of dissemination of ICT in schools. Meanwhile, we conducted a quantitative research to study the correlation between those latent variables: specific training in ICT and used ICT pedagogy on the TIC Educação 2014 data basis. To assign a measure to latent variables, we constructed four scales using the Item Response Theory (IRT). Two of them are training scales: the first one considers the institutionalized moments, while the second one takes the informative information of the assistant teachers into account. The other two are scales of use, one considering the activities with students and the other the actions of preparing classes. In order to explain the dependent variable use of ICT for pedagogy, we composed a linear regression model including as explanatory variables: the specific training variables in ICT and the control variables. The main results indicate that…

Advisors/Committee Members: MAGDA PISCHETOLA.

Subjects/Keywords: [pt] PRATICA PEDAGOGICA; [en] CLASSROOM PRACTICE; [pt] FORMACAO DE PROFESSORES; [en] TEACHERS FORMATION; [pt] FORMACAO CONTINUADA; [en] PROFESSIONAL TRAINING; [pt] TECNOLOGIA DA INFORMACAO E COMUNICACAO - TIC; [en] INFORMATION AND COMMUNICATION TECHNOLOGY - ICT; [pt] FORMACAO INICIAL; [en] INITIAL EDUCATION

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

BRASILINO, A. D. M. (2017). [en] TEACHERS TRAINING AND EDUCATIONAL PRACTICE WITH TECHNOLOGIES: A CORRELATIONAL STUDY ON THE TIC EDUCAÇÃO 2014 DATA BASIS. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31998

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BRASILINO, ALINE DE MENDONÇA. “[en] TEACHERS TRAINING AND EDUCATIONAL PRACTICE WITH TECHNOLOGIES: A CORRELATIONAL STUDY ON THE TIC EDUCAÇÃO 2014 DATA BASIS.” 2017. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31998.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BRASILINO, ALINE DE MENDONÇA. “[en] TEACHERS TRAINING AND EDUCATIONAL PRACTICE WITH TECHNOLOGIES: A CORRELATIONAL STUDY ON THE TIC EDUCAÇÃO 2014 DATA BASIS.” 2017. Web. 09 Dec 2019.

Vancouver:

BRASILINO ADM. [en] TEACHERS TRAINING AND EDUCATIONAL PRACTICE WITH TECHNOLOGIES: A CORRELATIONAL STUDY ON THE TIC EDUCAÇÃO 2014 DATA BASIS. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31998.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BRASILINO ADM. [en] TEACHERS TRAINING AND EDUCATIONAL PRACTICE WITH TECHNOLOGIES: A CORRELATIONAL STUDY ON THE TIC EDUCAÇÃO 2014 DATA BASIS. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=31998

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Pontifical Catholic University of Rio de Janeiro

30. RICARDO CORREIA DA SILVA E SOUZA. [en] TECHNOLOGY AND THE GAP BETWEEN UNIVERSITY EDUCATION AND TRANSLATION PRACTICE: A PROPOSED APPROACH.

Degree: 2017, Pontifical Catholic University of Rio de Janeiro

URL: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30788

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[pt] Esta dissertação se insere no contexto das discussões contemporâneas sobre abordagens às tecnologias da tradução na formação universitária de tradutores profissionais. Este estudo parte… (more)

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[pt] Esta dissertação se insere no contexto das discussões contemporâneas sobre abordagens às tecnologias da tradução na formação universitária de tradutores profissionais. Este estudo parte de uma análise de um afastamento percebido entre ensino universitário e prática profissional no âmbito estrito da formação de tradutores para investigar o papel do tratamento dispensado às tecnologias da tradução nessa conjuntura. Para tanto, como base teórica e metodológica, este trabalho usa postulados dos Estudos da Tradução sobre o objeto de seus ramos descritivos e aplicados e os estudos desenvolvidos pela pedagogia da tradução em torno do que seriam competências tradutórias para, então, propor um modo de inserção da tecnologia no processo de formação de tradutores. É feita, então, uma inclusão das tecnologias da tradução no contexto dos modernos Estudos de Ciência e Tecnologia em seus aspectos descritivos - notadamente os trabalhos sobre Ciência, Tecnologia e Sociedade (CTS) e a Teoria Ator-Rede (TAR) - para verificar expectativas sobre processos e resultados da tradução por causa da presença intensiva da tecnologia. Por fim, com base nas inter-relações expostas pelo exame anterior, este estudo sugere uma forma de abordagem às tecnologias da tradução na universidade que contribua para valorizar a universidade, reduzir o afastamento percebido entre ensino universitário e prática da tradução e destacar as pesquisas acadêmicas da tradução como protagonistas no âmbito das Humanidades Digitais.

[en] This work follows the contemporary discussions on how to approach the translation technologies in the education of professional translators. This study starts with an analysis of a perceived distance between university education and professional practice in the strict framework of translators training and education, and then investigates the role that current approaches to translation technology play in that scenario. Therefore, as a theoretical and methodological basis, this work uses postulates from Translation Studies on the object of their descriptive and applied branches, and from the translation pedagogy studies on translational competences, to propose a mode of inserting technology in the translator education process. Then, the translation technologies are included in the modern context of Science and Technology Studies in their descriptive aspects - notably the Science, Technology and Society (STS) studies, and the Actor-Network Theory (ANT) approach - in order to check expectations on translation processes and results associated with the intensive presence of translation technologies. Finally, based on the interrelations found during investigations, this study suggests an approach to translation technology at the university that would contribute to distinguish the university, reduce the distance perceived between university education and translation practice, and highlight the academic translation research as protagonist within the Digital Humanities studies.

Advisors/Committee Members: MARIA PAULA FROTA.

Subjects/Keywords: [pt] ESTUDOS DA TRADUCAO; [en] TRANSLATION STUDIES; [pt] TECNOLOGIAS DA TRADUCAO; [en] TRANSLATION TECHNOLOGIES; [pt] TECNOLOGIA E SOCIEDADE; [en] TECHNOLOGY AND SOCIETY; [pt] PEDAGOGIA DA TRADUCAO; [en] TRANSLATION PEDAGOGY; [pt] FORMACAO UNIVERSITARIA DO TRADUTOR; [en] UNIVERSITY TRANSLATOR TRAINING; [pt] PRATICA DA TRADUCAO; [en] TRANSLATION PRACTICE; [pt] COMPETENCIAS DO TRADUTOR; [en] TRANSLATOR COMPETENCE; [pt] EXPECTATIVAS DOS PUBLICOS DA TRADUCAO; [en] TRANSLATION PUBLIC S EXPECTATIONS; [pt] CURRICULO DE CURSO DE TRADUCAO; [en] TRANSLATION COURSE SYLLABUS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

SOUZA, R. C. D. S. E. (2017). [en] TECHNOLOGY AND THE GAP BETWEEN UNIVERSITY EDUCATION AND TRANSLATION PRACTICE: A PROPOSED APPROACH. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30788

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SOUZA, RICARDO CORREIA DA SILVA E. “[en] TECHNOLOGY AND THE GAP BETWEEN UNIVERSITY EDUCATION AND TRANSLATION PRACTICE: A PROPOSED APPROACH.” 2017. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed December 09, 2019. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30788.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SOUZA, RICARDO CORREIA DA SILVA E. “[en] TECHNOLOGY AND THE GAP BETWEEN UNIVERSITY EDUCATION AND TRANSLATION PRACTICE: A PROPOSED APPROACH.” 2017. Web. 09 Dec 2019.

Vancouver:

SOUZA RCDSE. [en] TECHNOLOGY AND THE GAP BETWEEN UNIVERSITY EDUCATION AND TRANSLATION PRACTICE: A PROPOSED APPROACH. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. [cited 2019 Dec 09]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30788.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SOUZA RCDSE. [en] TECHNOLOGY AND THE GAP BETWEEN UNIVERSITY EDUCATION AND TRANSLATION PRACTICE: A PROPOSED APPROACH. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2017. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=30788

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations