subject:( Y chromosome)

Oregon State University

1. Wyandt, Herman Edwin, 1939-. Study of the human Y chromosome in the interphase nucleus by light microscopy, quinacrine fluoromicroscopy and autoradiography.

Degree: PhD, Zoology, 1971, Oregon State University

URL: http://hdl.handle.net/1957/45432

► Part of the Y chromosome in humans is detectable as a brightly fluorescing body in interphase nuclei stained with quinacrine dyes. This fluorescent body when… (more)

▼ Part of the Y chromosome in humans is detectable as a brightly fluorescing body in interphase nuclei stained with quinacrine dyes. This fluorescent body when stained with quinacrine mustard dihydrochloride, in cells from some 15 human subjects, was seen to manifest a variable morphology which appeared to be related to the stage of the nucleus in the cell cycle. The variable morphology was seen particularly in cultured fibroblasts and in peripheral blood lymphocytes undergoing blastic transformation induced by PHA, but was not observed in buccal mucosa or hair root sheath cells. The morphology of the Y-body ranged from a highly condensed configuration in small non-transformed nuclei to increased degrees of dispersion which appeared to show direct relationship to size of the transformed nucleus. In nuclei which appeared to be in preprophase (G-2), the Y-body appeared to partially recondense. Lymphocyte cultures, which were serially harvested, showed an increase in percent of nuclei with a dispersed Y-body, proportional to time in culture, and generally an increase in nuclear diameter. Nuclei studied from serially cultured skin fibroblasts showed the highest percent of nuclei with a dispersed Y-body during the log phase of cell growth, and a decline in the frequency of dispersed morphology in the post-log phase. Percent dispersion also showed a direct relationship to mitotic index. Continuous terminal and pulse-labeling studies of the Y-body revealed increased incorporation of tritiated thymidine with increased dispersion. The labeling studies suggested that the observed morphological configurations were sequential, and that the Y-body while condensed generally lagged in DNA-synthesis, but that the rate of DNA-synthesis of the Y-body was more rapid than the rest of the nucleus as it became more dispersed. The studies indicate that the different morphologies of the Y-body represent stages in the cell cycle, and suggest that portions of the Y-body may be uncoiling during the time it is actively synthesizing DNA. Advisors/Committee Members: Owczarzak, Alfred (advisor).

Subjects/Keywords: Y chromosome

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APA (6^th Edition):

Wyandt, Herman Edwin, 1. (1971). Study of the human Y chromosome in the interphase nucleus by light microscopy, quinacrine fluoromicroscopy and autoradiography. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/45432

Chicago Manual of Style (16^th Edition):

Wyandt, Herman Edwin, 1939-. “Study of the human Y chromosome in the interphase nucleus by light microscopy, quinacrine fluoromicroscopy and autoradiography.” 1971. Doctoral Dissertation, Oregon State University. Accessed October 15, 2019. http://hdl.handle.net/1957/45432.

MLA Handbook (7^th Edition):

Wyandt, Herman Edwin, 1939-. “Study of the human Y chromosome in the interphase nucleus by light microscopy, quinacrine fluoromicroscopy and autoradiography.” 1971. Web. 15 Oct 2019.

Vancouver:

Wyandt, Herman Edwin 1. Study of the human Y chromosome in the interphase nucleus by light microscopy, quinacrine fluoromicroscopy and autoradiography. [Internet] [Doctoral dissertation]. Oregon State University; 1971. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1957/45432.

Council of Science Editors:

Wyandt, Herman Edwin 1. Study of the human Y chromosome in the interphase nucleus by light microscopy, quinacrine fluoromicroscopy and autoradiography. [Doctoral Dissertation]. Oregon State University; 1971. Available from: http://hdl.handle.net/1957/45432

Cornell University

2. Kelsey, Keegan. Natural Genetic Variation Involved In Chromatin Modification .

Degree: 2016, Cornell University

URL: http://hdl.handle.net/1813/43655

► Gene expression is strongly influenced by local chromatin state, begging the question of what role population genetic factors play in driving variability in chromatin state.… (more)

▼ Gene expression is strongly influenced by local chromatin state, begging the question of what role population genetic factors play in driving variability in chromatin state. Using a combination of traditional D. melanogaster crosses, fully sequenced genomes, and computational methods, we survey global autosomal variation that impacts position effect variegation (PEV), a traditional proxy for chromatin state. We find little evidence for involvement of segregating functional (non-synonymous) variants within >100 known autosomal modifiers of PEV. Instead, we find enrichment of small-effect variants located within regions of open chromatin, sites of origin recognition complex (ORC) binding, and highly occupied target (HOT) regions for transcription factors. These variants fail to fully explain observed phenotypic variance in PEV, with the remainder accounted for by variants with ever smaller effect sizes. Further, we note only a small proportion of variants are explained through geneenvironment interaction, and we find no evidence for transgenerational transmission of chromatin state. Next we constructed a set of Y-chromosome replacement lines to probe the means by which altered heterochromatin content can impact chromatin states elsewhere in the genome. We reveal surprisingly high levels of heterogeneity among Y chromosomes from inferred counts of repetitive kmers and transposable elements. These variants show signs of functional constraint along with association to PEV and exceptionally strong associations to transcript counts from RNA-seq. Rapid evolution of Y-linked kmers and their impact on global gene expression is apparent from the degree of inter-population heterogeneity, including population-specific repeats. In summary, we identify involvement of a historically overlooked source of variation with functional consequences to gene expression. This work has immediate impact to informing current medical GWAS practice, and has further implications for refining evolutionary models of gene regulation. Advisors/Committee Members: Mezey,Jason G. (committeeMember), Barbash,Daniel A. (committeeMember).

Subjects/Keywords: Natural variation; PEV; Y chromosome

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APA (6^th Edition):

Kelsey, K. (2016). Natural Genetic Variation Involved In Chromatin Modification . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/43655

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kelsey, Keegan. “Natural Genetic Variation Involved In Chromatin Modification .” 2016. Thesis, Cornell University. Accessed October 15, 2019. http://hdl.handle.net/1813/43655.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kelsey, Keegan. “Natural Genetic Variation Involved In Chromatin Modification .” 2016. Web. 15 Oct 2019.

Vancouver:

Kelsey K. Natural Genetic Variation Involved In Chromatin Modification . [Internet] [Thesis]. Cornell University; 2016. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1813/43655.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kelsey K. Natural Genetic Variation Involved In Chromatin Modification . [Thesis]. Cornell University; 2016. Available from: http://hdl.handle.net/1813/43655

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Mahoney, James Michael. Indentification of Abnormal Y Chromosomes in the Resident Population of Woodward State Hospital and School .

Degree: 1973, Drake U

URL: http://hdl.handle.net/2092/998

► The problem. The screening of 507 residents of Woodward State Hospital-School for possible Y chromosome anomalies using a quinacrine mustard staining technique. This stain causes… (more)

Subjects/Keywords: Y chromosome; Karyotypes; Chromosome abnormalities

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APA (6^th Edition):

Mahoney, J. M. (1973). Indentification of Abnormal Y Chromosomes in the Resident Population of Woodward State Hospital and School . (Thesis). Drake U. Retrieved from http://hdl.handle.net/2092/998

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mahoney, James Michael. “Indentification of Abnormal Y Chromosomes in the Resident Population of Woodward State Hospital and School .” 1973. Thesis, Drake U. Accessed October 15, 2019. http://hdl.handle.net/2092/998.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mahoney, James Michael. “Indentification of Abnormal Y Chromosomes in the Resident Population of Woodward State Hospital and School .” 1973. Web. 15 Oct 2019.

Vancouver:

Mahoney JM. Indentification of Abnormal Y Chromosomes in the Resident Population of Woodward State Hospital and School . [Internet] [Thesis]. Drake U; 1973. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/2092/998.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mahoney JM. Indentification of Abnormal Y Chromosomes in the Resident Population of Woodward State Hospital and School . [Thesis]. Drake U; 1973. Available from: http://hdl.handle.net/2092/998

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

4. Smith, Maren. Senescence and the Y chromosome.

Degree: BS, Biology, 2009, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/smith_maren_200912_bs

► The Y chromosome is a non-recombining, patrilineal chromosome that is comprised of a few male specific genes, repetitive sequences, and transposable elements (Graves 2006). It… (more)

Subjects/Keywords: Senescence; Y chromosome; Drosophila melanogaster; aging

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APA (6^th Edition):

Smith, M. (2009). Senescence and the Y chromosome. (Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/smith_maren_200912_bs

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Smith, Maren. “Senescence and the Y chromosome.” 2009. Thesis, University of Georgia. Accessed October 15, 2019. http://purl.galileo.usg.edu/uga_etd/smith_maren_200912_bs.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Smith, Maren. “Senescence and the Y chromosome.” 2009. Web. 15 Oct 2019.

Vancouver:

Smith M. Senescence and the Y chromosome. [Internet] [Thesis]. University of Georgia; 2009. [cited 2019 Oct 15]. Available from: http://purl.galileo.usg.edu/uga_etd/smith_maren_200912_bs.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Smith M. Senescence and the Y chromosome. [Thesis]. University of Georgia; 2009. Available from: http://purl.galileo.usg.edu/uga_etd/smith_maren_200912_bs

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

5. Paria, Nandina. Discovery of Candidate Genes for Stallion Fertility from the Horse Y Chromosome.

Degree: 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7047

► The genetic component of mammalian male fertility is complex and involves thousands of genes. The majority of these genes are distributed on autosomes and the… (more)

▼ The genetic component of mammalian male fertility is complex and involves thousands of genes. The majority of these genes are distributed on autosomes and the X chromosome, while a small number are located on the Y chromosome. Human and mouse studies demonstrate that the most critical Y-linked male fertility genes are present in multiple copies, show testis-specific expression and are different between species. In the equine industry, where stallions are selected according to pedigrees and athletic abilities but not for reproductive performance, reduced fertility of many breeding stallions is a recognized problem. Therefore, the aim of the present research was to acquire comprehensive information about the organization of the horse Y chromosome (ECAY), identify Y-linked genes and investigate potential candidate genes regulating stallion fertility. To achieve theses goals, a direct cDNA (complementary DNA) selection procedure was used to isolate Y-linked genes from horse testes and 29 Y-specific genes were identified. All 29 genes were mapped to ECAY and their sequences were used to further expand the existing map. Copy number analysis identified 15 multicopy genes of which 9 were novel transcripts. Gene expression analysis on a panel of selected body tissues showed that some ECAY genes are expressed exclusively in testes while others show ubiquitous or intermediate expression. Quantitative Real-Time PCR using primers for 9 testis-specific multicopy genes revealed 5 genes with statistically significant differential expression in testis of normal fertile stallions and stallions with impaired fertility. Gene copy number analysis showed that the average copy number of 4 such genes was decreased in subfertile/infertile stallions compared to normal animals. Taken together, this research generated the first comprehensive physical gene map for the horse Y chromosome and identified a number of candidate genes for stallion fertility. The findings essentially expand our knowledge about Y chromosome genes in horses, open a new avenue for investigating the potential role of ECAY genes in stallion fertility which contribute to the development of molecular tools for the assessment of fertility in stallions. Advisors/Committee Members: Raudsepp, Terje (advisor), Chowdhary, Bhanu P. (committee member), Murphy, William J. (committee member), Samollow, Paul B. (committee member), Varner, Dickson D. (committee member).

Subjects/Keywords: Y chromosome; Stallion fertility; candidate genes; horse

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APA (6^th Edition):

Paria, N. (2012). Discovery of Candidate Genes for Stallion Fertility from the Horse Y Chromosome. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Paria, Nandina. “Discovery of Candidate Genes for Stallion Fertility from the Horse Y Chromosome.” 2012. Thesis, Texas A&M University. Accessed October 15, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Paria, Nandina. “Discovery of Candidate Genes for Stallion Fertility from the Horse Y Chromosome.” 2012. Web. 15 Oct 2019.

Vancouver:

Paria N. Discovery of Candidate Genes for Stallion Fertility from the Horse Y Chromosome. [Internet] [Thesis]. Texas A&M University; 2012. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Paria N. Discovery of Candidate Genes for Stallion Fertility from the Horse Y Chromosome. [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-7047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

6. Guo, Yue. Characterization, annotation and expression patterns of bovine X-degenerate Y-chromosome genes UTY, ZFY, USP9Y, PRKY, RPS4Y, TBL1Y and their isoforms.

Degree: MS, Animal Sciences, 2016, University of Minnesota

URL: http://hdl.handle.net/11299/183299

► The X degenerate region of the bovine male specific region of the Y chromosome (bMSY) harbors several single copy genes, these genes share high similarity… (more)

▼ The X degenerate region of the bovine male specific region of the Y chromosome (bMSY) harbors several single copy genes, these genes share high similarity with homologous genes on the X chromosome (Chang et.al. 2012). Y chromosome genes were assumed to play an important role in maleness and spermatogenesis through the whole life of males. Understanding the function of MSY genes would provide an indication of their role in maleness and spermatogenesis and contribute to effect early age male selection in breeding programs. The purpose of this research was to obtain full sequence of these genes, identify their isoforms and expression patterns in male and female animals, through single molecule RNA sequencing and PCR amplification of gene sequences across 15 different tissues samples. Comparison to their human and mouse orthologues helped assess the structure and level of conservation of these genes. Our hypothesis is that the X-degenerate Y-encoded and X-encoded genes and their isoforms will exhibit expression variation between male and female across different tissues, and that the Y-encoded genes will have specific expression patterns in male tissues. The mRNA isoform sequence (Iso-Seq) (Pacific Bioscience, CA) information was used to identify transcripts from Domino in liver and testis and from his daughter Dominette in liver, muscle, thalamus, lung and adipose. This analysis identified one isoform for bZFY, six isoforms for bZFX; two isoforms for bUTY, five isoforms for bUTX; three isoforms for bUSP9Y, fourteen isoforms for bUSP9X; eight isoforms for bRPS4Y1, five isoforms for bRPS4X; four potential isoforms for bTBL1Y, three potential isoforms for bTBL1X and three isoforms for bPRKX. We identified sequence regions of low homology to develop specific priming sites targeting the PCR amplification of fragments for ZFY and ZFX, UTY and UTX, USP9Y and USP9X, and successfully separated their expression pattern across 15 different tissues in four new born Holstein males and females. Furthermore, the orthologous comparison of bovine genes/genomes to the human and mouse genomes were also analyzed. Results from this dissertation identified possible sex specific isoforms of bovine X-degenerate Y-encoded genes and its homolog X-chromosome genes, and it refined the database information for the mRNA sequence of those bovine genes. Moreover, it provided a comprehensive list of orthologous bovine X-degenerate Y-chromosome genes in other mammals, which provides a knowledge background to promote functional research for those X-degenerate gene in maleness. Further research needs to be focused on how expression of these genes at different developmental stages of males will regulate their male specific biological functions.

Subjects/Keywords: bovine; X-degenerate genes; Y chromosome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guo, Y. (2016). Characterization, annotation and expression patterns of bovine X-degenerate Y-chromosome genes UTY, ZFY, USP9Y, PRKY, RPS4Y, TBL1Y and their isoforms. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/183299

Chicago Manual of Style (16^th Edition):

Guo, Yue. “Characterization, annotation and expression patterns of bovine X-degenerate Y-chromosome genes UTY, ZFY, USP9Y, PRKY, RPS4Y, TBL1Y and their isoforms.” 2016. Masters Thesis, University of Minnesota. Accessed October 15, 2019. http://hdl.handle.net/11299/183299.

MLA Handbook (7^th Edition):

Guo, Yue. “Characterization, annotation and expression patterns of bovine X-degenerate Y-chromosome genes UTY, ZFY, USP9Y, PRKY, RPS4Y, TBL1Y and their isoforms.” 2016. Web. 15 Oct 2019.

Vancouver:

Guo Y. Characterization, annotation and expression patterns of bovine X-degenerate Y-chromosome genes UTY, ZFY, USP9Y, PRKY, RPS4Y, TBL1Y and their isoforms. [Internet] [Masters thesis]. University of Minnesota; 2016. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/11299/183299.

Council of Science Editors:

Guo Y. Characterization, annotation and expression patterns of bovine X-degenerate Y-chromosome genes UTY, ZFY, USP9Y, PRKY, RPS4Y, TBL1Y and their isoforms. [Masters Thesis]. University of Minnesota; 2016. Available from: http://hdl.handle.net/11299/183299

University of Arizona

7. Tumonggor, Meryanne Kusnita. Genetic Insights On The Human Colonization Of Indonesia .

Degree: 2014, University of Arizona

URL: http://hdl.handle.net/10150/332827

► Indonesia, a vast archipelago nation and home to a wide range of cultural, linguistic and genetic diversity, has been a navel of intercultural and interregional… (more)

▼ Indonesia, a vast archipelago nation and home to a wide range of cultural, linguistic and genetic diversity, has been a navel of intercultural and interregional interaction between the Asian and the Pacific worlds since prehistoric times. By analyzing the genetic profile of Indonesian people across the archipelago, this dissertation aims to elucidate the colonization history of Indonesia and to assess the effect of social practices on the Indonesian gene pool. Genetic diversity has revealed the complex settlement history of the Indonesian archipelago, starting from the initial colonization of Indonesia ~50 kya, multiple migrations by hunter-gatherers from mainland Asia during the Paleolithic era, followed by a major Neolithic expansion of Austronesian-speaking farmers from a putative homeland of Taiwan, and historic era migrations that involved several foreign invasions via trading and the spread of major religions. The survival of older lineages in western and eastern Indonesia showed that these later expansions into the archipelago did not replace the gene pool of the previous inhabitants. Although most Indonesian communities today practice patrilocality, which is supported by genetic diversity and population structure analyses, matrilineal descent systems are thought to have dominated ancestral Austronesian societies. Preserving a rich Austronesian cultural heritage, such as matrilocal marriage practices, has particularly affected the genetic diversity and population structure of Timor. The dominance of Asian female lineages is apparent on the X chromosome compared to the autosomes, suggesting that female migrants played a leading role during the period of Asian immigration into Timor. Matrilocality may have been a driving force behind this admixture bias during the Austronesian expansion. This finding provides support for an Austronesian `house society' model in which the Austronesian expansion led to the dispersal of matrilocal societies with small numbers of neighboring non-Austronesian males marrying into Austronesian matrilocal, matrilineal houses. This study has revealed that the colonization history of Indonesia does not seem to comprise merely a Melanesian substratum with a single expansion of Austronesian speakers, yet rather involves multiple waves of human migration, coupled with an extensive admixture process. Advisors/Committee Members: Lansing, John Stephen (advisor), Lansing, John Stephen (committeemember), Pike, Ivy L. (committeemember), Cox, Murray P, (committeemember), Raichlen, David A. (committeemember).

Subjects/Keywords: Indonesia; mitochondrial DNA; Y chromosome; Anthropology; Austronesian

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APA (6^th Edition):

Tumonggor, M. K. (2014). Genetic Insights On The Human Colonization Of Indonesia . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/332827

Chicago Manual of Style (16^th Edition):

Tumonggor, Meryanne Kusnita. “Genetic Insights On The Human Colonization Of Indonesia .” 2014. Doctoral Dissertation, University of Arizona. Accessed October 15, 2019. http://hdl.handle.net/10150/332827.

MLA Handbook (7^th Edition):

Tumonggor, Meryanne Kusnita. “Genetic Insights On The Human Colonization Of Indonesia .” 2014. Web. 15 Oct 2019.

Vancouver:

Tumonggor MK. Genetic Insights On The Human Colonization Of Indonesia . [Internet] [Doctoral dissertation]. University of Arizona; 2014. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/10150/332827.

Council of Science Editors:

Tumonggor MK. Genetic Insights On The Human Colonization Of Indonesia . [Doctoral Dissertation]. University of Arizona; 2014. Available from: http://hdl.handle.net/10150/332827

University of Hong Kong

8. Liu, Chun-ling, Girus. Development of flow cytometric method for analysis of X & Ychromosome.

Degree: Master of Medical Sciences, 2005, University of Hong Kong

URL: Liu, C. G. [廖俊凌]. (2005). Development of flow cytometric method for analysis of X & Y chromosome. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4501019 ; http://dx.doi.org/10.5353/th_b4501019 ; http://hdl.handle.net/10722/131198

published_or_final_version

Medical Sciences

Master

Master of Medical Sciences

Subjects/Keywords: Y chromosome.; X chromosome.; Flow cytometry.

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APA (6^th Edition):

Liu, Chun-ling, G. (2005). Development of flow cytometric method for analysis of X & Ychromosome. (Masters Thesis). University of Hong Kong. Retrieved from Liu, C. G. [廖俊凌]. (2005). Development of flow cytometric method for analysis of X & Y chromosome. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4501019 ; http://dx.doi.org/10.5353/th_b4501019 ; http://hdl.handle.net/10722/131198

Chicago Manual of Style (16^th Edition):

Liu, Chun-ling, Girus. “Development of flow cytometric method for analysis of X & Ychromosome.” 2005. Masters Thesis, University of Hong Kong. Accessed October 15, 2019. Liu, C. G. [廖俊凌]. (2005). Development of flow cytometric method for analysis of X & Y chromosome. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4501019 ; http://dx.doi.org/10.5353/th_b4501019 ; http://hdl.handle.net/10722/131198.

MLA Handbook (7^th Edition):

Liu, Chun-ling, Girus. “Development of flow cytometric method for analysis of X & Ychromosome.” 2005. Web. 15 Oct 2019.

Vancouver:

Liu, Chun-ling G. Development of flow cytometric method for analysis of X & Ychromosome. [Internet] [Masters thesis]. University of Hong Kong; 2005. [cited 2019 Oct 15]. Available from: Liu, C. G. [廖俊凌]. (2005). Development of flow cytometric method for analysis of X & Y chromosome. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4501019 ; http://dx.doi.org/10.5353/th_b4501019 ; http://hdl.handle.net/10722/131198.

Council of Science Editors:

Liu, Chun-ling G. Development of flow cytometric method for analysis of X & Ychromosome. [Masters Thesis]. University of Hong Kong; 2005. Available from: Liu, C. G. [廖俊凌]. (2005). Development of flow cytometric method for analysis of X & Y chromosome. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4501019 ; http://dx.doi.org/10.5353/th_b4501019 ; http://hdl.handle.net/10722/131198

Case Western Reserve University

9. Anderson, Philip D. Genetic control of testicular germ cell tumor susceptibility in mice.

Degree: PhD, Genetics, 2009, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1247182449

► Testicular germ cell tumors (TGCTs) are the most common types of testicular cancer as well as the most common tumor in men aged 15… (more)

▼ Testicular germ cell tumors (TGCTs) are the most common types of testicular cancer as well as the most common tumor in men aged 15 – 34. Despite their prevalence, the genetic control of susceptibility is poorly understood. Family history suggests a strong genetic component to TGCT susceptibility, but studies have found only one rare, weakly associated Y-linked locus. The 129 family of inbred mouse strains is an established animal model of TGCTs. Linkage studies in mice have been largely unsuccessful, and no genes controlling susceptibility have been found. The goal of my research was to identify chromosomes and chromosomal regions containing TGCT QTLs (quantitative trait loci) using chromosome substitution strains (CSSs). My analysis showed that three CSSs have TGCT QTLs. To map the QTLs on chromosome 18, I made a panel of eight congenic strains from 129-Chr 18MOLF. I surveyed congenic males for TGCTs and found evidence for three previously unknown TGCT QTLs on chromosome 18. Because studies have shown conflicting evidence for a Y-linked factor(s) promoting TGCTs in humans, I tested the role of this chromosome on TGCT development in mice. Sry, the master sex-determining gene in mammals, is on the Y chromosome and is normally required for testis formation and male development. In the absence of the Y chromosome, mice develop as fertile females. To bypass the requirement for Sry in sexual development, I took advantage of the Odd Sex mutation that causes XX animals to develop as males without the Y chromosome. Sex-reversed XX males develop testes with PGCs, which enabled tests of whether the Y chromosome was required for TGCT tumorigenesis. Although normal males developed TGCTs at an appreciable rate, no TGCTs were found in sex-reversed males. I concluded that at least one factor on the Y chromosome was required for TGCT initiation. The results of my research support the theory that TGCTs are a highly complex trait, and that CSSs are an effective tool for mapping QTLs with weak effects. A more thorough understanding of the heritable component of TGCTs in mice will improve our understanding of the genetic control of susceptibility to complex diseases. Advisors/Committee Members: Molyneaux, Kathleen (Committee Chair), Nadeau, Joseph (Advisor).

Subjects/Keywords: Genetics; germ cell tumor; mouse models; TGCT; chromosome substitution strain; Y chromosome

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APA (6^th Edition):

Anderson, P. D. (2009). Genetic control of testicular germ cell tumor susceptibility in mice. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1247182449

Chicago Manual of Style (16^th Edition):

Anderson, Philip D. “Genetic control of testicular germ cell tumor susceptibility in mice.” 2009. Doctoral Dissertation, Case Western Reserve University. Accessed October 15, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1247182449.

MLA Handbook (7^th Edition):

Anderson, Philip D. “Genetic control of testicular germ cell tumor susceptibility in mice.” 2009. Web. 15 Oct 2019.

Vancouver:

Anderson PD. Genetic control of testicular germ cell tumor susceptibility in mice. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2009. [cited 2019 Oct 15]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1247182449.

Council of Science Editors:

Anderson PD. Genetic control of testicular germ cell tumor susceptibility in mice. [Doctoral Dissertation]. Case Western Reserve University; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1247182449

10. Vaz, Suzana Casaccia. Drosofilídeos (Diptera) associados a flores e fungos da mata atlântica: identificação de novas espécies e evolução do cromossomo Y.

Degree: PhD, Biologia (Genética), 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/41/41131/tde-09032015-073910/ ;

►

A análise do conteúdo gênico do cromossomo Y em 12 espécies de Drosophila com genoma sequenciado em 2008 mostrou que o Y é pouco conservado… (more)

▼

A análise do conteúdo gênico do cromossomo Y em 12 espécies de Drosophila com genoma sequenciado em 2008 mostrou que o Y é pouco conservado entre espécies e está em processo de aquisição de genes, o que contradiz o modelo atual de evolução de cromossomos sexuais que o descreve como um homólogo degenerado do X, com constante perda de genes. Este resultado inicial incitou o estudo espécies adicionais de Drosophila e de gêneros próximos. Uma dificuldade relevante para obtenção de espécimes é que muitos grupos taxonômicos de drosofilídeos não estão disponíveis nos “stock-centers”, e seus hábitos de vida são pouco conhecidos. Muitas espécies são encontradas na natureza associadas a fungos, flores, ou exsudados vegetais, e raramente são atraídas por isca com banana fermentada, que é o método usual de coleta de drosofilídeos. Os objetivos do presente trabalho foram: I) analisar o conteúdo gênico do cromossomo Y de drosofilídeos provenientes de substratos “não usuais”, II) determinar substratos de desenvolvimento larval e identificar espécies novas, e III) analisar a composição de bases de genes no Y. Os resultados revelam a natureza dinâmica de aquisição e perdas de genes do cromossomo Y na família Drosophilidae que, em poucos casos, inclui um movimento de todo o cromossomo (p.e., fusão do Y a um autossomo). Descrevemos uma nova espécie, Drosophila calatheae, cuja larva se desenvolve em flores do gênero Calathea (Marantaceae). Uma segunda espécie, provisoriamente codificada como Drosophila I4, e cujas larvas também se desenvolvem nessas flores, está em fase de descrição. A partir de análise morfológica, nenhuma dessas duas espécies pôde ser incluídas em algum dos grupos de espécies conhecidos. Uma filogenia molecular preliminar com dois genes do cromossomo Y (kl-3 and kl-5) sugere que ambas pertencem à radiação virilis-repleta e que D. calatheae tem relações (morfológicas e moleculares) com as espécies do grupo bromeliae. A análise do conteúdo GC de genes no Y mostrou que genes neste cromossomo são enriquecidos em AT em relação a genes autossômicos, e esta diferença na composição de bases é proporcional ao tempo que um gene está presente no Y. Portanto, o conteúdo GC pode servir como ferramenta no estudo da evolução do cromossomo Y ao determinar o estado ancestral de um gene (autossômico vs. ligado ao Y) e datar o movimento de genes entre esses dois compartimentos genômicos

The analyses of the Y chromosome gene content in 12 Drosophila species whose genome were sequenced in 2008 showed that the Y is not well conserved among species and is currently in the process of acquiring genes, contradicting the current model of sex chromosome evolution that describes the Y as a degenerate homolog of the X, in constant gene loss. This initial result prompted the study of additional Drosophila species and related genera. One of the difficulties in obtaining specimens is the fact that drosophilids from many taxonomic groups are not available in stock- centers and little is known about their ecology. Many…

Advisors/Committee Members: Carvalho, Antonio Bernardo de, Vilela, Carlos Ribeiro.

Subjects/Keywords: Breeding sites; Cromossomo Y; Drosofilídeos; Drosophilids; Sítios de desenvolvimento; Y-chromosome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vaz, S. C. (2014). Drosofilídeos (Diptera) associados a flores e fungos da mata atlântica: identificação de novas espécies e evolução do cromossomo Y. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/41/41131/tde-09032015-073910/ ;

Chicago Manual of Style (16^th Edition):

Vaz, Suzana Casaccia. “Drosofilídeos (Diptera) associados a flores e fungos da mata atlântica: identificação de novas espécies e evolução do cromossomo Y.” 2014. Doctoral Dissertation, University of São Paulo. Accessed October 15, 2019. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-09032015-073910/ ;.

MLA Handbook (7^th Edition):

Vaz, Suzana Casaccia. “Drosofilídeos (Diptera) associados a flores e fungos da mata atlântica: identificação de novas espécies e evolução do cromossomo Y.” 2014. Web. 15 Oct 2019.

Vancouver:

Vaz SC. Drosofilídeos (Diptera) associados a flores e fungos da mata atlântica: identificação de novas espécies e evolução do cromossomo Y. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2019 Oct 15]. Available from: http://www.teses.usp.br/teses/disponiveis/41/41131/tde-09032015-073910/ ;.

Council of Science Editors:

Vaz SC. Drosofilídeos (Diptera) associados a flores e fungos da mata atlântica: identificação de novas espécies e evolução do cromossomo Y. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/41/41131/tde-09032015-073910/ ;

Florida International University

11. Gayden, Tenzin. Genetic Diversity in the Himalayan Populations of Nepal and Tibet.

Degree: PhD, Biology, 2012, Florida International University

URL: http://digitalcommons.fiu.edu/etd/580 ; 10.25148/etd.FI12042312 ; FI12042312

► The Himalayan Mountain range encompasses an unparalleled landscape featuring some of the planet’s highest peaks, including Mount Everest. In the heart of this massive… (more)

▼ The Himalayan Mountain range encompasses an unparalleled landscape featuring some of the planet’s highest peaks, including Mount Everest. In the heart of this massive orographic barrier lies Nepal, sandwiched in the historically geostrategic position between the Tibetan plateau to the north and India in the south. Until recently, Nepalese and Tibetan populations remained poorly characterized genetically, partly because of their inaccessible geographical locations. In the present study, the genetic diversity of these two Himalayan populations is evaluated using different marker systems, including mitochondrial DNA (mtDNA) and Short Tandem Repeats (STRs) in the autosomes as well as on the Y-chromosome (Y-STR). While autosomal STRs are distributed throughout the genome and are biparentally inherited, the Y-chromosome and mtDNA are haploid markers and provide the paternal and maternal histories of the population, respectively. Fifteen autosomal STR loci were typed in 341 unrelated individuals from three Nepalese populations (188), namely Tamang (45), Newar (66) and Kathmandu (77), and a general collection from Tibet (153). These samples were also sequenced for the mtDNA control region and all of them were subsequently assigned to 75 different mtDNA haplogroups and sub-haplogroups by screening their diagnostic sites in the coding region using Restriction Fragment Length Polymorphism analysis and/or sequencing, thus achieving an unprecedented level of resolution. The results from the autosomal and mtDNA data suggest a Northeast Asian origin for the Himalayan populations, with significant genetic influence from the Indian subcontinent in Kathmandu and Newar, corroborating our previous Y-chromosome study. In contrast, Tibet displays a limited Indian component, suggesting that the Himalayan massif acted as a natural barrier for gene flow from the south. The presence of ancient Indian mtDNA lineages in Nepal implies that the region may have been inhabited by the earliest settlers who initially populated South Asia. In addition, seventeen Y-STR loci were analyzed in 350 Tibetan males from three culturally defined regions of historical Tibet: Amdo (88), Kham (109) and U-Tsang (153). The results demonstrate that the 17 Y-STR loci studied are highly polymorphic in all the three Tibetan populations examined and hence are useful for forensic cases, paternity testing and population genetic studies. Advisors/Committee Members: Rene J. Herrera, George T. Duncan, DeEtta K. Mills, Bruce R. McCord, Timothy M. Collins.

Subjects/Keywords: Himalayas; Nepal; Tibet; Y-chromosome; mtDNA; Y-STR; Autosomal STR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gayden, T. (2012). Genetic Diversity in the Himalayan Populations of Nepal and Tibet. (Doctoral Dissertation). Florida International University. Retrieved from http://digitalcommons.fiu.edu/etd/580 ; 10.25148/etd.FI12042312 ; FI12042312

Chicago Manual of Style (16^th Edition):

Gayden, Tenzin. “Genetic Diversity in the Himalayan Populations of Nepal and Tibet.” 2012. Doctoral Dissertation, Florida International University. Accessed October 15, 2019. http://digitalcommons.fiu.edu/etd/580 ; 10.25148/etd.FI12042312 ; FI12042312.

MLA Handbook (7^th Edition):

Gayden, Tenzin. “Genetic Diversity in the Himalayan Populations of Nepal and Tibet.” 2012. Web. 15 Oct 2019.

Vancouver:

Gayden T. Genetic Diversity in the Himalayan Populations of Nepal and Tibet. [Internet] [Doctoral dissertation]. Florida International University; 2012. [cited 2019 Oct 15]. Available from: http://digitalcommons.fiu.edu/etd/580 ; 10.25148/etd.FI12042312 ; FI12042312.

Council of Science Editors:

Gayden T. Genetic Diversity in the Himalayan Populations of Nepal and Tibet. [Doctoral Dissertation]. Florida International University; 2012. Available from: http://digitalcommons.fiu.edu/etd/580 ; 10.25148/etd.FI12042312 ; FI12042312

University of Florida

12. McNulty, Shannon. Human Y-Chromosome Library Construction for Next-Generation Sequencing.

Degree: 2013, University of Florida

URL: http://ufdc.ufl.edu/AA00060989

► The Y-chromosome is particularly useful for population history inferences through the investigation of haplogroup diversity among males. These haplogroups are defined by single nucleotide polymorphisms… (more)

Subjects/Keywords: Alleles; Enzymes; Genetic mutation; Human Y chromosome; Indexing; Libraries; Ligation; Polymerase chain reaction; Sequencing; Y chromosome; Haploidy; Population; Single nucleotide polymorphisms; Y chromosome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McNulty, S. (2013). Human Y-Chromosome Library Construction for Next-Generation Sequencing. (Thesis). University of Florida. Retrieved from http://ufdc.ufl.edu/AA00060989

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McNulty, Shannon. “Human Y-Chromosome Library Construction for Next-Generation Sequencing.” 2013. Thesis, University of Florida. Accessed October 15, 2019. http://ufdc.ufl.edu/AA00060989.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McNulty, Shannon. “Human Y-Chromosome Library Construction for Next-Generation Sequencing.” 2013. Web. 15 Oct 2019.

Vancouver:

McNulty S. Human Y-Chromosome Library Construction for Next-Generation Sequencing. [Internet] [Thesis]. University of Florida; 2013. [cited 2019 Oct 15]. Available from: http://ufdc.ufl.edu/AA00060989.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McNulty S. Human Y-Chromosome Library Construction for Next-Generation Sequencing. [Thesis]. University of Florida; 2013. Available from: http://ufdc.ufl.edu/AA00060989

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Kusuma, Pradiptajati. In search of Asian Malagasy ancestors in Indonesia : A la recherche des ancestres asiatiques des malgaches en Indonésie.

Degree: Docteur es, Anthropobiologie, 2017, Université Toulouse III – Paul Sabatier

URL: http://www.theses.fr/2017TOU30109

►

L'Indonésie a été l'objet de la dispersion Austronésienne qui a débuté il y a environ 5000 ans depuis Taiwan, se propager à travers les Philippines… (more)

▼

L'Indonésie a été l'objet de la dispersion Austronésienne qui a débuté il y a environ 5000 ans depuis Taiwan, se propager à travers les Philippines et l'Indonésie, puis toucher l'Océanie à l'est, et à Madagascar à l'ouest. Malgré de nombreuses recherches en génétique sur la dispersion Austronésienne vers l'est, il y a très peu de données sur la dispersion vers l'ouest, laissant sans réponse de nombreuses questions, liées notamment au peuplement de Madagascar. Reposant sur l'analyse des données culturelles et biologiques, les populations d'Indonésie semblent avoir joué un rôle majeur dans la colonisation de Madagascar, le premier millénaire de notre ère. Cependant, le peu de populations Indonésiennes étudiées à ce jour n'a pas permis jusqu'à présent d'identifier la population indonésienne source. Dans ce présent travail, j'ai réalisé des études en génétique des populations de 12 populations Indonésiennes, qui à priori devraient éclairer l'histoire des migrations austronésiennes dans l'Océan Indien. Parmi elles sont inclus le Ma'anyan du sud-est de Bornéo qui sont les plus proches linguistiquement des Malgaches. En utilisant différents marqueurs génétiques, ma recherche a amélioré nos connaissances de la diversité génétique Indonésienne, et du lien génétique entre l'Indonésie et Madagascar. Résultats L'analyse des marqueurs uniparentaux (chr-Y et ADNmt) suggère que les Malgaches proviennent de plusieurs régions d'Indonésie, avec un lien privilégié avec le sud-est de Bornéo, le sud de Sulawesi et les îles de la Sonde. Etonnamment, les Ma'anyan partagent un nombre limité de lignées paternelles et maternelles avec les Malgaches, malgré leur proximité linguistique. Par ailleurs, en combinant l'analyse de fréquences des SNPs et l'analyse haplotypique à partir des données autosomales, il a été confirmé que la diversité génétique des Ma'anyan ne correspond pas à l'ancestralité asiatique des Malgaches. Cependant, en centrant l'analyse sur les populations du sud-est de Bornéo, l'origine de l'ancestralité asiatique des Malgaches est ancrée dans la population Banjar, un mélange de population Ma'anyan et Malaise, résultat des activités commerciales de l'empire Malais dans le sud-est de Bornéo, qui se sont poursuivies à travers l'océan Indien. Par ailleurs nos résultats ont aussi permis d'accroitre notre compréhension de la diversité génétique de l'Indonésie en identifiant (1) une nouvelle composante génétique austronésienne présente chez les Ma'anyan, et retrouvée à faible fréquence à travers l'Asie du Sud-Est, suggérant une plus grande complexité du modèle d'expansion austronésien dans la région et (2) le rôle joué par les nomades de la mer dans la structuration de la diversité génétique et les échanges entre populations dans l'Indonésie, soulignant l'histoire génétique complexe de populations suivant un mode de vie nomade.

Indonesia hosts a wide range of linguistic, ethnic and genetic diversity, comprising ~600 ethnic groups and 700 living languages. Indonesia has facilitated the last substantial wave of human migration was…

Advisors/Committee Members: Ricaut, Francois-Xavier (thesis director), Letellier, Thierry (thesis director).

Subjects/Keywords: Indonésie; Malgache; Migration; ADNmt; Chromosome Y; SNP génome; Indonesia; Malagasy; Migration; MtDNA; Y-chromosome; Genome-wide SNP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kusuma, P. (2017). In search of Asian Malagasy ancestors in Indonesia : A la recherche des ancestres asiatiques des malgaches en Indonésie. (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2017TOU30109

Chicago Manual of Style (16^th Edition):

Kusuma, Pradiptajati. “In search of Asian Malagasy ancestors in Indonesia : A la recherche des ancestres asiatiques des malgaches en Indonésie.” 2017. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed October 15, 2019. http://www.theses.fr/2017TOU30109.

MLA Handbook (7^th Edition):

Kusuma, Pradiptajati. “In search of Asian Malagasy ancestors in Indonesia : A la recherche des ancestres asiatiques des malgaches en Indonésie.” 2017. Web. 15 Oct 2019.

Vancouver:

Kusuma P. In search of Asian Malagasy ancestors in Indonesia : A la recherche des ancestres asiatiques des malgaches en Indonésie. [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2017. [cited 2019 Oct 15]. Available from: http://www.theses.fr/2017TOU30109.

Council of Science Editors:

Kusuma P. In search of Asian Malagasy ancestors in Indonesia : A la recherche des ancestres asiatiques des malgaches en Indonésie. [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2017. Available from: http://www.theses.fr/2017TOU30109

Florida International University

14. Chennakrishnaiah, Shilpa. Analysis of Y-chromosome Diversity in Lingayat and Vokkaliga Populations of Southern India.

Degree: Forensic Science, 2011, Florida International University

URL: http://digitalcommons.fiu.edu/etd/423 ; 10.25148/etd.FI11072506 ; FI11072506

► Archaeological and genetic evidence have long supported the notion that the Indian subcontinent played an important role in the dispersal of modern humans out… (more)

Subjects/Keywords: Lingayat; Vokkaliga; Dravidian language; Y-chromosome; Y-SNP; Y-STR; diversity; phylogenetic analyses; southern India.

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APA (6^th Edition):

Chennakrishnaiah, S. (2011). Analysis of Y-chromosome Diversity in Lingayat and Vokkaliga Populations of Southern India. (Thesis). Florida International University. Retrieved from http://digitalcommons.fiu.edu/etd/423 ; 10.25148/etd.FI11072506 ; FI11072506

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chennakrishnaiah, Shilpa. “Analysis of Y-chromosome Diversity in Lingayat and Vokkaliga Populations of Southern India.” 2011. Thesis, Florida International University. Accessed October 15, 2019. http://digitalcommons.fiu.edu/etd/423 ; 10.25148/etd.FI11072506 ; FI11072506.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chennakrishnaiah, Shilpa. “Analysis of Y-chromosome Diversity in Lingayat and Vokkaliga Populations of Southern India.” 2011. Web. 15 Oct 2019.

Vancouver:

Chennakrishnaiah S. Analysis of Y-chromosome Diversity in Lingayat and Vokkaliga Populations of Southern India. [Internet] [Thesis]. Florida International University; 2011. [cited 2019 Oct 15]. Available from: http://digitalcommons.fiu.edu/etd/423 ; 10.25148/etd.FI11072506 ; FI11072506.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chennakrishnaiah S. Analysis of Y-chromosome Diversity in Lingayat and Vokkaliga Populations of Southern India. [Thesis]. Florida International University; 2011. Available from: http://digitalcommons.fiu.edu/etd/423 ; 10.25148/etd.FI11072506 ; FI11072506

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

15. Moussa, Nour M. Maternal and Paternal Polymorphisms in Prehistoric Siberian Populations of Lake Baikal.

Degree: PhD, Medical Sciences-Laboratory Medicine and Pathology, 2015, University of Alberta

URL: https://era.library.ualberta.ca/files/wm117r51m

► The study of Ancient DNA (aDNA), DNA recovered from archaeological and historic post mortem material, has complemented the study of anthropology and archaeology. There are… (more)

▼ The study of Ancient DNA (aDNA), DNA recovered from archaeological and historic post mortem material, has complemented the study of anthropology and archaeology. There are several challenges in the retrieval and analysis of DNA from ancient specimens including exogenous contamination with modern DNA, polymerase chain reaction (PCR) inhibitors and DNA damage because of environmental factors. Despite all the obstacles, the extraction of aDNA is still possible through reliable extraction methods and highly sensitive PCR-based technologies that facilitated the use of aDNA analysis in revealing the maternal and paternal backgrounds of ancient populations. This dissertation examines prehistoric hunter-gatherer populations that inhabited Siberia, Russia, several thousand years ago. The Lake Baikal of Siberia was home to two temporally distinct populations from Early Neolithic, EN (8000-6800 cal BP) to Late Neolithic-Early Bronze Age, LN-EBA (5800-4000 cal BP). The EN group was separated from the LN-EBA group by a 1000-year gap (hiatus). Several cemeteries have been excavated as part of an international Baikal Archaeology Project (BAP). These include one EN cemetery (Shamanka II) and two LN-EBA cemeteries (Kurma XI and Khuzhir-Nuge XIV). Maternally inherited mitochondrial DNA (mtDNA) has been examined previously for two EN cemeteries (Lokomotiv and Shamanka II) and one of the LN-EBA cemeteries (Ust’-Ida). mtDNA has not been analyzed before from the Kurma XI cemetery. This dissertation hypothesis focused on the examination of mtDNA from Shamanka II and Kurma XI cemeteries and examination of Y-chromosomal DNA from the four excavated cemeteries (Lokomotiv, Shamanka II, Ust’-Ida and Kurma XI) to identify genetic discontinuity and/or continuity between and within the EN and LN-EBA of prehistoric populations. The project aims were; first, modification of published methods for sample preparation, DNA extraction and PCR amplification for aDNA research. Second, interpretation of mtDNA haplogroup distribution from Kurma XI in the context of other Lake Baikal cemeteries. Third, compare the genetic affinities of the prehistoric populations with the contemporary populations of the area through the maternal lineage. Finally, comprison of mtDNA and Y-chromosomal haplogroup distributions to determine maternal and paternal genetic affinities. Four different mtDNA haplogroups were found in Kurma XI individuals including A, D, F and Z. mtDNA haplogroup Z was not represented before in Lake Baikal’s prehistoric populations. In addition, six extra samples from Shamanka II were analyzed to reveal that Shamanka II and Lokomotiv did not share the same maternal background as was previously suggested. New mtDNA results from Kurma XI and Shamanka II suggested that each of the EN cemeteries and LN-EBA cemeteries had a different maternal origin; however, Kurma XI shared a similar maternal origin with Lokomotiv and also with Shamanka II. Through SNaPshot multiplex PCR amplification, Y-chromosomal haplogroups were obtained from male individuals in the four…

Subjects/Keywords: Prehistoric Siberian Populations; mtDNA and Y-chromosome; Ancient DNA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moussa, N. M. (2015). Maternal and Paternal Polymorphisms in Prehistoric Siberian Populations of Lake Baikal. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/wm117r51m

Chicago Manual of Style (16^th Edition):

Moussa, Nour M. “Maternal and Paternal Polymorphisms in Prehistoric Siberian Populations of Lake Baikal.” 2015. Doctoral Dissertation, University of Alberta. Accessed October 15, 2019. https://era.library.ualberta.ca/files/wm117r51m.

MLA Handbook (7^th Edition):

Moussa, Nour M. “Maternal and Paternal Polymorphisms in Prehistoric Siberian Populations of Lake Baikal.” 2015. Web. 15 Oct 2019.

Vancouver:

Moussa NM. Maternal and Paternal Polymorphisms in Prehistoric Siberian Populations of Lake Baikal. [Internet] [Doctoral dissertation]. University of Alberta; 2015. [cited 2019 Oct 15]. Available from: https://era.library.ualberta.ca/files/wm117r51m.

Council of Science Editors:

Moussa NM. Maternal and Paternal Polymorphisms in Prehistoric Siberian Populations of Lake Baikal. [Doctoral Dissertation]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/wm117r51m

Temple University

16. Latham, Krista Erin. Assessing Y-Chromosome Variation in the South Pacific Using Newly Detected NRY Markers.

Degree: PhD, 2008, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,5736

►

Anthropology

The South Pacific is a region of incredible biological, cultural and linguistic diversity, reflecting its early settlement by human populations. It has been a… (more)

▼

Anthropology

The South Pacific is a region of incredible biological, cultural and linguistic diversity, reflecting its early settlement by human populations. It has been a region of interest to scholars because of this diversity, as well as its unique geography and settlement history. Current evidence suggests there was an initial settlement of Near Oceania during the Pleistocene by Papuan-speaking foragers, followed by a later Holocene settlement of Remote Oceania by Oceanic-speaking agriculturalists. Previous studies of human biological variation have been used to illuminate the migration history of and population relationships within Oceania. In this study, I analyzed Y-chromosome (NRY) diversity in 842 unrelated males to more fully characterize the phylogeography of paternal genetic lineages in this region, using a large number of regionally informative markers on an intensive sample set from Northern Island Melanesia. This approach facilitated an analysis of NRY haplogroup distributions, an evaluation of the ancestral paternal genetic contribution to the region, and a comparison of regional NRY diversity with that observed at different genetic loci (e.g., mtDNA). This project is part of a collaborative effort by faculty and graduate students from the Temple University Department of Anthropology that focused on characterizing biological variation and genetic structure in Melanesia, and better resolving the phylogeographic specificity of Northern Island Melanesia. Overall, this study generated a higher resolution view of NRY haplogroup variation than detected in previous studies through the use of newly defined and very informative SNP markers. It also showed that there is a very small ancestral East Asian paternal contribution to this area, and a rather large proportion of older Melanesian NRY lineages present there. In addition, this study observed extraordinary NRY diversity within Northern Island Melanesia, as well as genetic structure influenced more by geography than linguistic variation. This structure and diversity was essentially equivalent to that noted for mtDNA data for this region. Finally, this study helped to resolve questions about the placement of the 50f2/c deletion within the larger NRY tree. Overall, this work has refined our understanding of the migration and demographic history of Northern Island Melanesia.

Temple University – Theses

Advisors/Committee Members: Friedlaender, Jonathan Scott, Lorenz, Joseph G., Weitz, Charles A., Greenfield, Leonard, Schurr, Theodore G. (Theodore George).

Subjects/Keywords: Anthropology, Physical; Y-Chromosome; NRY; South Pacific; Melanesia; Population Genetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Latham, K. E. (2008). Assessing Y-Chromosome Variation in the South Pacific Using Newly Detected NRY Markers. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,5736

Chicago Manual of Style (16^th Edition):

Latham, Krista Erin. “Assessing Y-Chromosome Variation in the South Pacific Using Newly Detected NRY Markers.” 2008. Doctoral Dissertation, Temple University. Accessed October 15, 2019. http://digital.library.temple.edu/u?/p245801coll10,5736.

MLA Handbook (7^th Edition):

Latham, Krista Erin. “Assessing Y-Chromosome Variation in the South Pacific Using Newly Detected NRY Markers.” 2008. Web. 15 Oct 2019.

Vancouver:

Latham KE. Assessing Y-Chromosome Variation in the South Pacific Using Newly Detected NRY Markers. [Internet] [Doctoral dissertation]. Temple University; 2008. [cited 2019 Oct 15]. Available from: http://digital.library.temple.edu/u?/p245801coll10,5736.

Council of Science Editors:

Latham KE. Assessing Y-Chromosome Variation in the South Pacific Using Newly Detected NRY Markers. [Doctoral Dissertation]. Temple University; 2008. Available from: http://digital.library.temple.edu/u?/p245801coll10,5736

University of Oxford

17. Cooper, Katrina. Analysis of the centromeric region of the human Y chromosome.

Degree: 1992, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:a86ed79c-84cd-40da-8da9-3afb9acf513d ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305982

► The centromere is an important region of the chromosome which ensures correct segregation at cell division. The DNA sequences which make up human centromeres are… (more)

Subjects/Keywords: 572.8; Y chromosome : Centromere : Analysis

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APA (6^th Edition):

Cooper, K. (1992). Analysis of the centromeric region of the human Y chromosome. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:a86ed79c-84cd-40da-8da9-3afb9acf513d ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305982

Chicago Manual of Style (16^th Edition):

Cooper, Katrina. “Analysis of the centromeric region of the human Y chromosome.” 1992. Doctoral Dissertation, University of Oxford. Accessed October 15, 2019. http://ora.ox.ac.uk/objects/uuid:a86ed79c-84cd-40da-8da9-3afb9acf513d ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305982.

MLA Handbook (7^th Edition):

Cooper, Katrina. “Analysis of the centromeric region of the human Y chromosome.” 1992. Web. 15 Oct 2019.

Vancouver:

Cooper K. Analysis of the centromeric region of the human Y chromosome. [Internet] [Doctoral dissertation]. University of Oxford; 1992. [cited 2019 Oct 15]. Available from: http://ora.ox.ac.uk/objects/uuid:a86ed79c-84cd-40da-8da9-3afb9acf513d ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305982.

Council of Science Editors:

Cooper K. Analysis of the centromeric region of the human Y chromosome. [Doctoral Dissertation]. University of Oxford; 1992. Available from: http://ora.ox.ac.uk/objects/uuid:a86ed79c-84cd-40da-8da9-3afb9acf513d ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305982

University of Edinburgh

18. Kaiser, Vera B. Molecular evolution under low recombination.

Degree: 2009, University of Edinburgh

URL: http://hdl.handle.net/1842/3946

► Analyzing regions in the genome with low levels of recombination helps understand the prevalence of sexual reproduction. Here, I show that variability in regions of… (more)

Subjects/Keywords: 572.8; genomic engineering; recombination; mutation; neo-Y chromosome

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APA (6^th Edition):

Kaiser, V. B. (2009). Molecular evolution under low recombination. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/3946

Chicago Manual of Style (16^th Edition):

Kaiser, Vera B. “Molecular evolution under low recombination.” 2009. Doctoral Dissertation, University of Edinburgh. Accessed October 15, 2019. http://hdl.handle.net/1842/3946.

MLA Handbook (7^th Edition):

Kaiser, Vera B. “Molecular evolution under low recombination.” 2009. Web. 15 Oct 2019.

Vancouver:

Kaiser VB. Molecular evolution under low recombination. [Internet] [Doctoral dissertation]. University of Edinburgh; 2009. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/1842/3946.

Council of Science Editors:

Kaiser VB. Molecular evolution under low recombination. [Doctoral Dissertation]. University of Edinburgh; 2009. Available from: http://hdl.handle.net/1842/3946

University of Akron

19. Farkas, Joel A. Sequence Analysis of Sry in Four Strains of Rattus norvegicus.

Degree: MS, Biology, 2008, University of Akron

URL: http://rave.ohiolink.edu/etdc/view?acc_num=akron1216386632

► Hypertension is a growing problem in the United States, exerting a great toll on the national health and economy. The Rattus norvegicus Spontaneously Hypertensive Rat… (more)

▼ Hypertension is a growing problem in the United States, exerting a great toll on the national health and economy. The Rattus norvegicus Spontaneously Hypertensive Rat (SHR) strain has been the preferred physiological model for the study of essential hypertension for decades. Both humans and rats show a pattern of Y chromosome linked hypertension, consistent with a conserved Y chromosome hypertensive locus in mammals. The Y chromosome gene, Sry has long been known for testis determination in mammals, but transcription in adult male tissues and reported effects on regulatory pathways makes Sry a candidate gene for the Y chromosome hypertensive locus. While most mammals have a single Sry locus on the Y chromosome, several rodent species have been shown to have multiple loci. Previously, six divergent loci of Sry had been identified in The University of Akron’s SHR (SHR/Akr) strain, with full coding region and conserved reading frame, but differing by SNPs and insertions/deletions. Here, sequence data of Sry loci was expanded to include more flanking sequence in SHR/Akr and three additional rat strains, with the intent of identifying hypertensive sequence variants in SHR/Akr. The University of Akron’s Wistar Kyoto (WKY/Akr) strain and Charles River Labs SHR (SHR/crl) strain are closely related strains, which both possess a normotensive Y chromosome. Harlan Sprague Dawley’s Sprague Dawley (SD/hsd) strain is an unrelated strain with a normotensive Y chromosome. Sequence data was determined from the sequencing of clones produced from amplified genomic DNA as well as direct sequencing of PCR products. In addition to the coding region, nearly 400bp of 5’ flanking, and 1200bp of 3’ flanking regions were sequenced, from each strain. All strains possess six shared Sry loci. These six loci are identical in SHR/Akr, WKY/Akr, and SHR/crl strains. Minor SNP differences in were found in SD/hsd, consistent with a more distant relationship from the other strains. An additional Sry locus, Sry3, was only found only in the SHR strains. Sequence differences in Sry3 between the SHR/Akr and SHR/crl strains are consistent with the observed differences in Y chromosome hypertension. This suggests that Sry3 is responsible for Y chromosome hypertension. Advisors/Committee Members: Turner, Monte (Advisor).

Subjects/Keywords: Bioinformatics; Biology; Sry; Hypertension; SHR; Y chromosome; Rattus norvegicus; rat

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APA (6^th Edition):

Farkas, J. A. (2008). Sequence Analysis of Sry in Four Strains of Rattus norvegicus. (Masters Thesis). University of Akron. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=akron1216386632

Chicago Manual of Style (16^th Edition):

Farkas, Joel A. “Sequence Analysis of Sry in Four Strains of Rattus norvegicus.” 2008. Masters Thesis, University of Akron. Accessed October 15, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1216386632.

MLA Handbook (7^th Edition):

Farkas, Joel A. “Sequence Analysis of Sry in Four Strains of Rattus norvegicus.” 2008. Web. 15 Oct 2019.

Vancouver:

Farkas JA. Sequence Analysis of Sry in Four Strains of Rattus norvegicus. [Internet] [Masters thesis]. University of Akron; 2008. [cited 2019 Oct 15]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1216386632.

Council of Science Editors:

Farkas JA. Sequence Analysis of Sry in Four Strains of Rattus norvegicus. [Masters Thesis]. University of Akron; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=akron1216386632

20. Ruthig, Victor. Microscopic and Macroscopic Investigations of Male Development Anatomy and Fertility, and the Role of Y Chromosome Genes.

Degree: 2017, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/51504

►

Ph.D. University of Hawaii at Manoa 2016.

There have been decades of work on the Y chromosome and how it relates to maleness and male… (more)

▼

Ph.D. University of Hawaii at Manoa 2016.

There have been decades of work on the Y chromosome and how it relates to maleness and male reproduction. In light of the increasing decline of human male fertility and dependence on assisted reproduction more knowledge about the causes behind male infertility is needed to find more solutions for affected men. This dissertation details histological investigations aiming to elucidate function of Y chromosome genes in male development and fertility using a mouse model. The testis and the seminiferous tubules within were explored and spermatogenesis was quantitatively assessed. Males lacking Y chromosome and transgenic for either the key Y-derived transgenes (Sry and Eif2s3y) or transgenes of their non Y-derived homologues (Sox9 and Eif2s3x) were shown to produce haploid germ cells that could be used for assisted reproduction technologies (ART) and yield live offspring. Another Y chromosome gene, Zfy2, was identified as a gene allowing for transformation of round spermatids into sperm. While in males with only two Y chromosome genes, Sry and Eif2s3y, spermatogenesis progressed to round spermatid stage, addition of Zfy2 allowed for complete spermatogenesis and formation of sperm capable of generating offspring with ART. Investigations into the testicular abnormalities in mice with limited Y chromosome gene contribution showed relationship between the number of Y genes present and the severity and distribution of cellular abnormalities in the seminiferous epithelium and defects of the testis interstitium. Human spermatogenesis was also histologically investigated utilizing testis biopsies from normal and infertile men, some with Y chromosome azoospermic factor (AZF) deletions, validating mice with Y chromosome deficiencies as a model for human male Y-linked infertility. Gross anatomy investigations into human male urogenital anatomy were also undertaken using a novel dissection method in order to grow the repository of male urogenital teaching tools at the medical school. Both examined specimens had common male genital pathologies (direct inguinal hernia, varicocele) and so also showcase physical abnormalities that can affect male reproductive health.

Subjects/Keywords: Y chromosome; spermatogenesis; male development; male fertility; male anatomy; testis histology

13 more images…

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APA (6^th Edition):

Ruthig, V. (2017). Microscopic and Macroscopic Investigations of Male Development Anatomy and Fertility, and the Role of Y Chromosome Genes. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/51504

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ruthig, Victor. “Microscopic and Macroscopic Investigations of Male Development Anatomy and Fertility, and the Role of Y Chromosome Genes.” 2017. Thesis, University of Hawaii – Manoa. Accessed October 15, 2019. http://hdl.handle.net/10125/51504.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ruthig, Victor. “Microscopic and Macroscopic Investigations of Male Development Anatomy and Fertility, and the Role of Y Chromosome Genes.” 2017. Web. 15 Oct 2019.

Vancouver:

Ruthig V. Microscopic and Macroscopic Investigations of Male Development Anatomy and Fertility, and the Role of Y Chromosome Genes. [Internet] [Thesis]. University of Hawaii – Manoa; 2017. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/10125/51504.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ruthig V. Microscopic and Macroscopic Investigations of Male Development Anatomy and Fertility, and the Role of Y Chromosome Genes. [Thesis]. University of Hawaii – Manoa; 2017. Available from: http://hdl.handle.net/10125/51504

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Louisville

21. Mann, Allison. Vikings, merchants, and pirates at the top of the world : Y-chromosomal signatures of recent and ancient migrations in the Faroe Islands.

Degree: MA, 2012, University of Louisville

URL: 10.18297/etd/901 ; https://ir.library.louisville.edu/etd/901

► The Faroe Islands are a small archipelago in the North Atlantic. With a current population of approximately 49,000 individuals and evidence of high levels… (more)

Subjects/Keywords: Faroes; Genetics; Y chromosome; Island; Population history; Network

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APA (6^th Edition):

Mann, A. (2012). Vikings, merchants, and pirates at the top of the world : Y-chromosomal signatures of recent and ancient migrations in the Faroe Islands. (Masters Thesis). University of Louisville. Retrieved from 10.18297/etd/901 ; https://ir.library.louisville.edu/etd/901

Chicago Manual of Style (16^th Edition):

Mann, Allison. “Vikings, merchants, and pirates at the top of the world : Y-chromosomal signatures of recent and ancient migrations in the Faroe Islands.” 2012. Masters Thesis, University of Louisville. Accessed October 15, 2019. 10.18297/etd/901 ; https://ir.library.louisville.edu/etd/901.

MLA Handbook (7^th Edition):

Mann, Allison. “Vikings, merchants, and pirates at the top of the world : Y-chromosomal signatures of recent and ancient migrations in the Faroe Islands.” 2012. Web. 15 Oct 2019.

Vancouver:

Mann A. Vikings, merchants, and pirates at the top of the world : Y-chromosomal signatures of recent and ancient migrations in the Faroe Islands. [Internet] [Masters thesis]. University of Louisville; 2012. [cited 2019 Oct 15]. Available from: 10.18297/etd/901 ; https://ir.library.louisville.edu/etd/901.

Council of Science Editors:

Mann A. Vikings, merchants, and pirates at the top of the world : Y-chromosomal signatures of recent and ancient migrations in the Faroe Islands. [Masters Thesis]. University of Louisville; 2012. Available from: 10.18297/etd/901 ; https://ir.library.louisville.edu/etd/901

Kent State University

22. Toot, Jonathan. The SHR Y Chromosome: Involvement in mechanisms influencing learning, memory, and aggression in the rodent model.

Degree: PhD, College of Biomedical Sciences, 2007, Kent State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=kent1195484838

► The goal of this research was to establish the SHR/y and WKY males as an animal model to study the SHR Y chromosome in relationship… (more)

▼ The goal of this research was to establish the SHR/y and WKY males as an animal model to study the SHR Y chromosome in relationship to learning, memory, and also aggression. After this, the focus of the remaining studies were then to identify novel neural, physiological, and genetic mechanisms involving the Y chromosome, and more specifically, the transcription factor Sry in these previously mentioned behavioral processes. Previous work in our lab has identified that the SHR Y chromosome contributes to various physiological phenotypes of increased sympathetic nervous system activity, elevated pre-pubertal testosterone, increased stress responsiveness, and also decreased brain serotonin content. Therefore, the hypotheses of the following aims include: Aim I, the SHR Y chromosome impairs learning and memory water maze performance using the morris water maze; Aim II, the SHR Y chromosome increases behavioral and physiological indices of aggression; and Aim III, the candidate gene, Sry, is responsible for the impaired maze performance and increased aggression in SHR Y chromosome males. The results of the first aim supported the hypothesis, showing impaired maze performance following: social stress, corticosterone manipulation, pre-pubertal social stress, and aging in SHR Y chromosome males. The results of the second aim also supported the hypothesis, showing increased aggression in socially housed, testosterone treated, and also in both testosterone and serotonin manipulated SHR Y chromosome males. The hypothesis for the third aim was also supported with neurochemistry data showing altered hippocampal norepinephrine content, increased hippocampal tyrosine hydroxylase activity, and decreased amygdala serotonin content. However, these changes in brain neurochemistry did not correspond to changes in either maze performance or aggressive behavior. Therefore, the results from these studies indicate that the SHR Y chromosome is taking part in a complex behavioral mechanism, potentially through Sry, that impairs learning and memory, and is also able to increase indices of aggression in the rodent model. Advisors/Committee Members: Ely, Daniel (Advisor).

Subjects/Keywords: Biology, General; SHR; WKY; Testosterone; Corticosterone; Serotonin; AGGRESSION; SHR Y CHROMOSOME

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APA (6^th Edition):

Toot, J. (2007). The SHR Y Chromosome: Involvement in mechanisms influencing learning, memory, and aggression in the rodent model. (Doctoral Dissertation). Kent State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=kent1195484838

Chicago Manual of Style (16^th Edition):

Toot, Jonathan. “The SHR Y Chromosome: Involvement in mechanisms influencing learning, memory, and aggression in the rodent model.” 2007. Doctoral Dissertation, Kent State University. Accessed October 15, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1195484838.

MLA Handbook (7^th Edition):

Toot, Jonathan. “The SHR Y Chromosome: Involvement in mechanisms influencing learning, memory, and aggression in the rodent model.” 2007. Web. 15 Oct 2019.

Vancouver:

Toot J. The SHR Y Chromosome: Involvement in mechanisms influencing learning, memory, and aggression in the rodent model. [Internet] [Doctoral dissertation]. Kent State University; 2007. [cited 2019 Oct 15]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1195484838.

Council of Science Editors:

Toot J. The SHR Y Chromosome: Involvement in mechanisms influencing learning, memory, and aggression in the rodent model. [Doctoral Dissertation]. Kent State University; 2007. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1195484838

Penn State University

23. Campos Sanchez, Rebeca. Evolution of genome architecture: from transposable elements distribution to Y chromosome gene structure.

Degree: PhD, Genetics, 2015, Penn State University

URL: https://etda.libraries.psu.edu/catalog/27199

► The topic of genome architecture is of great interest to evolutionary biologists. Small to large chromosome rearrangements have been reorganizing the genome information, including genes… (more)

▼ The topic of genome architecture is of great interest to evolutionary biologists. Small to large chromosome rearrangements have been reorganizing the genome information, including genes and heterochromatic regions such as centromeres and telomeres. Transposable elements (TEs) are an essential component of the genomes of all life forms studied until now, not only because of their abundance but also because of their influence on reshaping the genome architecture. Multiple studies have provided evidence that TEs are located in particular regions of the genome (e.g. GC-rich regions for Alus, or AT-rich regions for L1s). Here, using abundant genomic data and statistical methods as diverse as pair-wise non-parametric tests, multiple linear regression, multiple negative binomial regression, multiple logistic regression, interval testing procedure (ITP), and functional logistic regression (FLR), we addressed two questions about TE biology: 1. How do Alus’, DNA transposons’, and endogenous retroviruses’ (ERVs’) neighboring regions reflect integration site preferences and fixation processes for these TEs? What genomic features are associated with their presence genome-wide? 2. Can we capture integration site preferences alone using data from young, polymorphic or ex vivo integrations? The results from the TE analyses contributed to our understanding of fixation and integration site preferences genome-wide providing abundant information from diverse genomic features. This information is of great importance to direct studies of insertional mutagenesis and gene therapy. Additionally, we provided a set of statistical tools to analyze complex genomic datasets. Moreover, we explored the genes on the Y chromosome of gorilla. We performed this by first, generating Y-specific transcripts from testis RNAseq data; second, by evaluating their structure in the Y chromosome assembly; third, by using these transcripts to scaffold the Y chromosome assembly. Finally, we predicted novel genes from the assembly that could have been transposed from other chromosomes. This project allowed us to create a workflow to assemble Y transcripts from testis samples; this protocol will be applied in future studies. In addition, we proved the usefulness of transcriptome data to scaffold genomes.

Subjects/Keywords: genome architecture; transposable elements; genomic features; testis transcriptome; Y chromosome genes

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APA (6^th Edition):

Campos Sanchez, R. (2015). Evolution of genome architecture: from transposable elements distribution to Y chromosome gene structure. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/27199

Chicago Manual of Style (16^th Edition):

Campos Sanchez, Rebeca. “Evolution of genome architecture: from transposable elements distribution to Y chromosome gene structure.” 2015. Doctoral Dissertation, Penn State University. Accessed October 15, 2019. https://etda.libraries.psu.edu/catalog/27199.

MLA Handbook (7^th Edition):

Campos Sanchez, Rebeca. “Evolution of genome architecture: from transposable elements distribution to Y chromosome gene structure.” 2015. Web. 15 Oct 2019.

Vancouver:

Campos Sanchez R. Evolution of genome architecture: from transposable elements distribution to Y chromosome gene structure. [Internet] [Doctoral dissertation]. Penn State University; 2015. [cited 2019 Oct 15]. Available from: https://etda.libraries.psu.edu/catalog/27199.

Council of Science Editors:

Campos Sanchez R. Evolution of genome architecture: from transposable elements distribution to Y chromosome gene structure. [Doctoral Dissertation]. Penn State University; 2015. Available from: https://etda.libraries.psu.edu/catalog/27199

Harvard University

24. Jiang, Pan-Pan. Patterns of molecular evolution and epistasis on a genomic and genic scale.

Degree: PhD, Biology, Organismic and Evolutionary, 2013, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808

► Epistasis describes non-additive interactions which affect gene expression and phenotype. It can happen on multiple levels, including on a genomic level with interactions between genes… (more)

Subjects/Keywords: Biology; Genetics; Evolution & development; drug resistance; epistasis; heterochromatin; malaria; Y chromosome

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APA (6^th Edition):

Jiang, P. (2013). Patterns of molecular evolution and epistasis on a genomic and genic scale. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808

Chicago Manual of Style (16^th Edition):

Jiang, Pan-Pan. “Patterns of molecular evolution and epistasis on a genomic and genic scale.” 2013. Doctoral Dissertation, Harvard University. Accessed October 15, 2019. http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808.

MLA Handbook (7^th Edition):

Jiang, Pan-Pan. “Patterns of molecular evolution and epistasis on a genomic and genic scale.” 2013. Web. 15 Oct 2019.

Vancouver:

Jiang P. Patterns of molecular evolution and epistasis on a genomic and genic scale. [Internet] [Doctoral dissertation]. Harvard University; 2013. [cited 2019 Oct 15]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808.

Council of Science Editors:

Jiang P. Patterns of molecular evolution and epistasis on a genomic and genic scale. [Doctoral Dissertation]. Harvard University; 2013. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808

McMaster University

25. Ghenu, Ana-Hermina. Multicopy gene family evolution on primate Y chromosomes.

Degree: MSc, 2015, McMaster University

URL: http://hdl.handle.net/11375/18277

►

Unlike the autosomes, the Y chromosome in humans and other primates has few protein coding genes, with only a few dozen single-copy genes and several… (more)

Subjects/Keywords: Y chromosome; gene copy number evolution; Old World Primates; genome structure

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APA (6^th Edition):

Ghenu, A. (2015). Multicopy gene family evolution on primate Y chromosomes. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/18277

Chicago Manual of Style (16^th Edition):

Ghenu, Ana-Hermina. “Multicopy gene family evolution on primate Y chromosomes.” 2015. Masters Thesis, McMaster University. Accessed October 15, 2019. http://hdl.handle.net/11375/18277.

MLA Handbook (7^th Edition):

Ghenu, Ana-Hermina. “Multicopy gene family evolution on primate Y chromosomes.” 2015. Web. 15 Oct 2019.

Vancouver:

Ghenu A. Multicopy gene family evolution on primate Y chromosomes. [Internet] [Masters thesis]. McMaster University; 2015. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/11375/18277.

Council of Science Editors:

Ghenu A. Multicopy gene family evolution on primate Y chromosomes. [Masters Thesis]. McMaster University; 2015. Available from: http://hdl.handle.net/11375/18277

Université de Sherbrooke

26. Grégoire, Marie-Chantal. Étude de l'inactivation des kinétochores à l'aide de deux isodicentriques du bras long du chromosome Y caractérisés par les techniques de cytogénétique .

Degree: 2008, Université de Sherbrooke

URL: http://savoirs.usherbrooke.ca/handle/11143/3969

► La cytogénétique est une branche de la génétique qui étudie les chromosomes et leur intégrité ainsi que les conséquences de leur transmission et de leur… (more)

▼ La cytogénétique est une branche de la génétique qui étudie les chromosomes et leur intégrité ainsi que les conséquences de leur transmission et de leur expression. Plusieurs syndromes et maladies ont pu être expliqués par cette discipline. Certaines anomalies chromosomiques de structure ont d'ailleurs contribué à identifier des gènes, des fonctions de gènes ou à caractériser des structures chromosomiques. Dans cet ordre d'idées, nous avons utilisé deux isodicentriques du bras long du chromosome Y (idic(Y)(p11.3)) pour étudier la fonction d'une protéine du kinétochore, CENP-B, dans le mécanisme d'inactivation de kinétochore. Pour ce faire, nous avons premièrement fait une caractérisation cytogénétique des deux idic(Y)(p11.3) à l'aide des techniques de cytogénétique classique et de cytogénétique moléculaire. Nous avons ainsi déterminé approximativement le point de cassure des deux isodicentriques, soit en Yp11.3. Comme les deux chromosomes avaient une structure très semblable, mais que les patients présentaient un phénotype clinique très différent, nous avons investigué les niveaux de mosaïcisme dans différents tissus chez les deux patients. Il est connu qu'un chromosome possédant deux centromères capables de former le kinétochore peut être très instable lors des divisions cellulaires. Ainsi, la cellule a mis au point un mécanisme permettant d'inactiver un des kinétochores du chromosome dicentrique. Une récente revue a proposé que la protéine CENP-B jouerait un rôle dans ce mécanisme. Cependant, comme le chromosome Y ne possède pas la séquence d'ADN liant cette protéine, il était intéressant de vérifier si une inactivation des kinétochores avait eu lieu dans nos idic(Y)(p11.3). À l'aide d'un anticorps dirigé contre la protéine CENP-C, connue comme un marqueur de kinétochore actif, nous avons montré que plus de 40% des chromosomes dicentriques avaient subi une inactivation d'un de leur kinétochore. Enfin, la présence de la protéine CENP-B dans ces kinétochores a été étudiée. Nous avons montré que la protéine CENP-B était présente à tous les autres centromères, sauf ceux de l'idic(Y)(p11.3). Ainsi, nous proposons que la protéine CENP-B n'est pas impliquée directement dans le mécanisme d'inactivation de kinétochore du chromosome Y. Par contre, nous ne pouvons pas exclure qu'elle joue un rôle indirect, soit par une interaction protéine/protéine, soit à une étape en amont dans le mécanisme d'inactivation. Advisors/Committee Members: [non identifié] (advisor).

Subjects/Keywords: Hybridation in situ en fluorescence; Immunohistochimie; Centromère; Kkinétochore; Chromosome Y isodicentrique

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APA (6^th Edition):

Grégoire, M. (2008). Étude de l'inactivation des kinétochores à l'aide de deux isodicentriques du bras long du chromosome Y caractérisés par les techniques de cytogénétique . (Masters Thesis). Université de Sherbrooke. Retrieved from http://savoirs.usherbrooke.ca/handle/11143/3969

Chicago Manual of Style (16^th Edition):

Grégoire, Marie-Chantal. “Étude de l'inactivation des kinétochores à l'aide de deux isodicentriques du bras long du chromosome Y caractérisés par les techniques de cytogénétique .” 2008. Masters Thesis, Université de Sherbrooke. Accessed October 15, 2019. http://savoirs.usherbrooke.ca/handle/11143/3969.

MLA Handbook (7^th Edition):

Grégoire, Marie-Chantal. “Étude de l'inactivation des kinétochores à l'aide de deux isodicentriques du bras long du chromosome Y caractérisés par les techniques de cytogénétique .” 2008. Web. 15 Oct 2019.

Vancouver:

Grégoire M. Étude de l'inactivation des kinétochores à l'aide de deux isodicentriques du bras long du chromosome Y caractérisés par les techniques de cytogénétique . [Internet] [Masters thesis]. Université de Sherbrooke; 2008. [cited 2019 Oct 15]. Available from: http://savoirs.usherbrooke.ca/handle/11143/3969.

Council of Science Editors:

Grégoire M. Étude de l'inactivation des kinétochores à l'aide de deux isodicentriques du bras long du chromosome Y caractérisés par les techniques de cytogénétique . [Masters Thesis]. Université de Sherbrooke; 2008. Available from: http://savoirs.usherbrooke.ca/handle/11143/3969

University of the Western Cape

27. Burrows, Adria Michelle. A comparative ancestry analysis of Y-chromosome DNA haplogroups using high resolution melting .

Degree: 2018, University of the Western Cape

URL: http://hdl.handle.net/11394/6536

► The objective of this study is to deduce paternal ancestry using ancestry informative single nucleotide polymorphisms (SNPs) by means of High Resolution Melting (HRM). This… (more)

Subjects/Keywords: Haplogroups; Y-Chromosome; African ancestry; Multiplex; Coloured population; High resolution melting

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burrows, A. M. (2018). A comparative ancestry analysis of Y-chromosome DNA haplogroups using high resolution melting . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/6536

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Burrows, Adria Michelle. “A comparative ancestry analysis of Y-chromosome DNA haplogroups using high resolution melting .” 2018. Thesis, University of the Western Cape. Accessed October 15, 2019. http://hdl.handle.net/11394/6536.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Burrows, Adria Michelle. “A comparative ancestry analysis of Y-chromosome DNA haplogroups using high resolution melting .” 2018. Web. 15 Oct 2019.

Vancouver:

Burrows AM. A comparative ancestry analysis of Y-chromosome DNA haplogroups using high resolution melting . [Internet] [Thesis]. University of the Western Cape; 2018. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/11394/6536.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Burrows AM. A comparative ancestry analysis of Y-chromosome DNA haplogroups using high resolution melting . [Thesis]. University of the Western Cape; 2018. Available from: http://hdl.handle.net/11394/6536

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas State University – San Marcos

28. Herrera, Brianne. Genetic and Craniometric Comparative Analysis of Three Mexican Populations.

Degree: MA, Anthropology, 2013, Texas State University – San Marcos

URL: https://digital.library.txstate.edu/handle/10877/4618

► Previous research has shown that craniometric data can serve as a proxy for molecular data (Relethford 2001, Roseman 2004) and that cranial shape is somewhat… (more)

▼ Previous research has shown that craniometric data can serve as a proxy for molecular data (Relethford 2001, Roseman 2004) and that cranial shape is somewhat shaped by gene flow (Relethford 2004). Previous research on admixture frequencies suggests that complex population histories resulting from differential admixture account for the complex patterns of biological variation found throughout Mexico (Merriwether et al. 1997, Juárez-Cedillo et al. 2008). The purpose of this study is to test whether or not craniometric data show the same population patterns as molecular data and if so, can it be used to help reconstruct population history for archaeological groups in North and Central Mexico. Craniometric data were obtained from the Sonora, Michoácan, and Tlanepantla groups, dating between AD 1200 and 1500 (Beekman and Christensen 2003) and curated at the American Museum of Natural History. Molecular data were obtained that best approximated the craniometric groups, including the Tarahumara, Purépecha, and the Otomi. Allele distributions forsix Y-linked short tandem repeats (STRs) in the Tarahumara and Purepécha populations were obtained from previously published data (Rangel-Villalobos et al. 2008). Allele distributions for the same six Y-linked STRs in the Otomi population were also studied (Barrot et al. 2007). Mitochondrial DNA (mtDNA) haplogroup frequencies from the same populations, Tarahumara, Purépecha, and Otomi, were used as well (Peñaloza-Espinosa et al. 2007). Distance matrices for the molecular data were obtained in the Kship program (Jantz, no date) and the craniometric distance matrix was obtained in Rmet (Relethford, 2003). Mantel tests were also performed. There were no statistically significant correlations found. Evidence for patrilocality was seen with the FST estimates and the distance matrices. When geography was considered, it was found that populations that were farthest away had the strongest similarity, except in the case of mtDNA, in which the most similar followed geographic distance. Advisors/Committee Members: Spradley, Kate (advisor), Bolnick, Deborah (committee member), Hamilton, Michelle (committee member).

Subjects/Keywords: Mexican; mtDNA; Y-chromosome; Craniometric; Human remains (Archaeology) – Mexico; Anthropology; Craniometry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herrera, B. (2013). Genetic and Craniometric Comparative Analysis of Three Mexican Populations. (Masters Thesis). Texas State University – San Marcos. Retrieved from https://digital.library.txstate.edu/handle/10877/4618

Chicago Manual of Style (16^th Edition):

Herrera, Brianne. “Genetic and Craniometric Comparative Analysis of Three Mexican Populations.” 2013. Masters Thesis, Texas State University – San Marcos. Accessed October 15, 2019. https://digital.library.txstate.edu/handle/10877/4618.

MLA Handbook (7^th Edition):

Herrera, Brianne. “Genetic and Craniometric Comparative Analysis of Three Mexican Populations.” 2013. Web. 15 Oct 2019.

Vancouver:

Herrera B. Genetic and Craniometric Comparative Analysis of Three Mexican Populations. [Internet] [Masters thesis]. Texas State University – San Marcos; 2013. [cited 2019 Oct 15]. Available from: https://digital.library.txstate.edu/handle/10877/4618.

Council of Science Editors:

Herrera B. Genetic and Craniometric Comparative Analysis of Three Mexican Populations. [Masters Thesis]. Texas State University – San Marcos; 2013. Available from: https://digital.library.txstate.edu/handle/10877/4618

29. Souza, Gustavo Reis Branco de. Determinação do polifomorfismo de 11 marcadores microssatélites do cromossomo Y nas comunidades quilombolas do estado de Alagoas.

Degree: 2010, Universidade Federal de Alagoas

URL: http://www.repositorio.ufal.br/handle/riufal/931

►

Several approaches using molecular biology techniques and the social sciences has been employed in order to clarify the involvement of Africans and their descendants in… (more)

▼

Several approaches using molecular biology techniques and the social sciences has been employed in order to clarify the involvement of Africans and their descendants in the history of Brazil. The African presence in America dates back to the sixteenth century when men and women were sold as slaves to serve as manpower in the colonies of Europe. It is estimated that since that time more than 15 million people have been brought forcibly to the Americas, 40% had Brazil as a destination. These Africans and their descendants started swapping genes with Europeans and Indians who inhabited the region. However, is not yet known in detail the participation of Africans in shaping history and genetics of population. Difficult access to detailed history of Africans and their descendants in Brazil is due largely to lack of documents and other historical data and geography, and only recently modern techniques of molecular biology have allowed a detailed analysis of the origin and migration of peoples. Quilombo communities are remnants of Quilombo, which were groups of runaway slaves and freedmen, located in remote and inaccessible. Quilombo is a Bantu word which means warrior camp in the forest. This study aimed to determine the polymorphism of 11 microsatellite markers on the Y chromosome in the maroon communities of the State of Alagoas. We analyzed 11 microsatellite loci of 211 men in nine maroon communities of the State of Alagoas, identified 108 haplotypes. The haplotype diversity varied from 0.7464 ± 0.0907 (Muquém) to 0.9794 ± 0.0594 (Carrasco), suggesting that there is significant founder effect in these communities. Analysis of molecular variance (AMOVA) revealed that populations have maroon marked heterogeneity, with 25.4% of the variation due to differences among the 74.6% and intrapopulation differences. The ancient African lineages, Amerindian and European is quite varied, noting that some populations are genetically closer to European and other populations of African populations.

Fundação de Amparo a Pesquisa do Estado de Alagoas

Diversas abordagens utilizando técnicas de biologia molecular e de ciências sociais tem sido empregadas com a finalidade de esclarecer a participação dos africanos e seus descendentes na historia do Brasil. A presença do africano na América remonta ao século XVI, quando homens e mulheres foram comercializados como escravos para servirem de mão-de-obra nas colônias européias. Estima se que desde essa época mais de 15 milhões de pessoas tenham sido trazidas forçadamente para o continente americano, sendo que 40% delas tiveram o Brasil como destino. Esses africanos e seus descendentes iniciaram troca de genes com europeus e índios que já habitavam a região. No entanto, ainda não se conhece em detalhes a participação dos africanos na formação histórica e genética da população brasileira. A dificuldade de acesso à historia detalhada dos africanos e seus descendentes no Brasil se deve em grande parte a escassez de documentos e outros dados histórico-geográficos, e só recentemente técnicas…

Advisors/Committee Members: Silva, Luiz Antonio Ferreira da, CPF:18269427004, SILVA, L. A. F., Carvalho, Elizeu Fagundes de, CPF:46328246749, http://lattes.cnpq.br/2742420738858309, Tovar, Francisco Javier, CPF:02177610702, http://lattes.cnpq.br/2366497420587582, Azevedo, Dalmo Almeida de, CPF:49935275949, http://lattes.cnpq.br/4202083703695616.

Subjects/Keywords: Genética humana; Quilombolas Alagoas; Cromossomo Y; Marcadores genéticos do cromossomo Y; Human genetics; Quilombolas Alagoas; Y-Chromosome; Genetic markers on chromosome Y; CNPQ::CIENCIAS DA SAUDE

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, G. R. B. d. (2010). Determinação do polifomorfismo de 11 marcadores microssatélites do cromossomo Y nas comunidades quilombolas do estado de Alagoas. (Masters Thesis). Universidade Federal de Alagoas. Retrieved from http://www.repositorio.ufal.br/handle/riufal/931

Chicago Manual of Style (16^th Edition):

Souza, Gustavo Reis Branco de. “Determinação do polifomorfismo de 11 marcadores microssatélites do cromossomo Y nas comunidades quilombolas do estado de Alagoas.” 2010. Masters Thesis, Universidade Federal de Alagoas. Accessed October 15, 2019. http://www.repositorio.ufal.br/handle/riufal/931.

MLA Handbook (7^th Edition):

Souza, Gustavo Reis Branco de. “Determinação do polifomorfismo de 11 marcadores microssatélites do cromossomo Y nas comunidades quilombolas do estado de Alagoas.” 2010. Web. 15 Oct 2019.

Vancouver:

Souza GRBd. Determinação do polifomorfismo de 11 marcadores microssatélites do cromossomo Y nas comunidades quilombolas do estado de Alagoas. [Internet] [Masters thesis]. Universidade Federal de Alagoas; 2010. [cited 2019 Oct 15]. Available from: http://www.repositorio.ufal.br/handle/riufal/931.

Council of Science Editors:

Souza GRBd. Determinação do polifomorfismo de 11 marcadores microssatélites do cromossomo Y nas comunidades quilombolas do estado de Alagoas. [Masters Thesis]. Universidade Federal de Alagoas; 2010. Available from: http://www.repositorio.ufal.br/handle/riufal/931

Universidade do Rio Grande do Sul

30. Machado, Rafael Bisso. Vestígios do passado : a história ameríndia revelada através de marcadores genéticos.

Degree: 2010, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/25142

► Este trabalho teve como meta principal contribuir para elucidar algumas das questões em aberto pertinentes à história evolutiva e antropológica de populações nativas americanas. Para… (more)

▼ Este trabalho teve como meta principal contribuir para elucidar algumas das questões em aberto pertinentes à história evolutiva e antropológica de populações nativas americanas. Para isso investigou-se marcadores uniparentais paternos, ligados à NRY, e materno, mtDNA. Para o cromossomo Y foram investigados 108 indivíduos (85 sulameríndios de 16 tribos, pertencentes a 5 grupos lingüísticos, além de 23 asiáticos (siberianos), compreendendo 6 grupos étnicos distintos). Para o mtDNA foram investigados 160 indivíduos (homens e mulheres), compreendendo 10 tribos sulamericanas, pertencentes a 5 grupos lingüísticos distintos. Para o cromossomo Y foram utilizados 26 marcadores (SNPs). Para o mtDNA a região controladora-RC (HVS-I: da posição 16.024 até 16.569, e HVS-II: da posição 001 até 576) e a região imediatamente 5’ à região controladora foram seqüenciadas. Foi possível determinar para o cromossomo Y que Q1a3a* (autóctone nativo-americano, de provável origem beringiana) está fixado em 63% das tribos; o haplogrupo Q1a3*, que por outro lado também é encontrado na Ásia, foi observado entre os Araweté (25%), Jamamadi (100%), Lengua (25%) e esquimós asiáticos (17%). Merece destaque que Q1a3* parece ser o que até agora era identificado como sendo apenas “haplogrupo Q*”, ou seja, cromossomo Y portador do alelo derivado no loco M242, mas com alelo ancestral para o M3. Nenhuma das novas mutações mencionadas na atual árvore filogenética do cromossomo Y (com exceção do M346, que define Q1a3*) foram encontradas. O seqüenciamento de regiões do cromossomo Y não revelou nenhuma nova mutação. No caso do mtDNA, os indígenas do tronco Ge mostram os haplogrupos B e A como sendo os mais freqüentes, enquanto que nos Tupi esses haplogrupos apresentam freqüências mais elevadas apenas em regiões bastante restritas, ficando o haplogrupo D como o mais freqüente. Cabe salientar que o haplogrupo C apresenta freqüência muito baixa tanto para os Ge quanto para os Tupi, sendo que freqüências um pouco mais elevadas estão quase que geograficamente opostas, ficando no sul do Brasil para os Ge e no norte para os Tupi. Avaliando o modelo de fissão-fusão pôde-se sugerir que: 1) As linhagens mitocondriais tribo-específicas dentro das tribos Kayapó aqui investigadas dificilmente representariam linhagens autóctones, já que o tempo de surgimento de cada tribo por processo de fissão é pequeno para comportar uma rede de novas mutações. As especificidades poderiam estar vinculadas ao modelo de fissão envolvendo grupos de pessoas aparentadas via materna. Nesse caso, grupos de parentes carregariam para fora do grupo parental todas as seqüências pertencentes a uma determinada linhagem. Assim a linhagem estaria presente somente no grupo derivado e não mais no parental; 2) Perda de linhagens parentais na dispersão e/ou por deriva na formação do novo grupo, o que resultaria na diferença encontrada entre os grupos derivados; 3) Embora não se possa excluir alguma fusão posterir a fissão, a quantidade de linhages exclusivas nas tribos Kayapó estaria indicando relativo… Advisors/Committee Members: Bortolini, Maria Cátira.

Subjects/Keywords: Y chromosome; Genética de populações; Marcadores genéticos; mtDNA; Ameríndios; HVS; Amerindians; Cromossomo Y

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Machado, R. B. (2010). Vestígios do passado : a história ameríndia revelada através de marcadores genéticos. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/25142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Machado, Rafael Bisso. “Vestígios do passado : a história ameríndia revelada através de marcadores genéticos.” 2010. Thesis, Universidade do Rio Grande do Sul. Accessed October 15, 2019. http://hdl.handle.net/10183/25142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Machado, Rafael Bisso. “Vestígios do passado : a história ameríndia revelada através de marcadores genéticos.” 2010. Web. 15 Oct 2019.

Vancouver:

Machado RB. Vestígios do passado : a história ameríndia revelada através de marcadores genéticos. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2010. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/10183/25142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Machado RB. Vestígios do passado : a história ameríndia revelada através de marcadores genéticos. [Thesis]. Universidade do Rio Grande do Sul; 2010. Available from: http://hdl.handle.net/10183/25142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations