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You searched for subject:( Tricycloundecane). One record found.

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University of the Western Cape

1. Egunlusi, Ayodeji Olatunde. Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection .

Degree: 2014, University of the Western Cape

This study focused on the synthesis of a series of novel tricycloundecane derivatives and evaluation of these compounds for neuroprotection using the fluorescent ratiometric calcium assay that indicates the ability of the test compounds to inhibit NMDA receptors and VGCC. The cycloaddition reaction between p-benzoquinone and monomerised dicyclopentadiene yielded tricycloundeca- 4,9-diene-3,6-dione which was used as the base structure and further derivatised. These derivatives were conjugated with benzylamine to form a series of imines and amines. A total of 10 compounds were synthesised for evaluation of inhibition of calcium influx through NMDA receptor channels and voltage-gated calcium channels. The structures were confirmed using NMR, IR and MS. On the proton NMR, the characteristic AB-quartet system was observed in the region of 1-2 ppm for all the compounds and the aromatic moiety was observed between 6.5-7.5 ppm for the novel polycyclic amines. These, with other functional groups, were used to confirm the individual structures Advisors/Committee Members: Joubert, Jacques (advisor), Malan, Sarel (advisor).

Subjects/Keywords: Neurodegenerative disorders; Tricycloundecane; N-methyl-D-aspartate receptor; Voltage-gated calcium channel; Oxidative stress; Synaptoneurosomes; Excitotoxicity; Apoptosis; Necrosis; Polycyclic cage; Neuroprotective agents; Fura-2 AM

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Egunlusi, A. O. (2014). Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/3904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Egunlusi, Ayodeji Olatunde. “Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection .” 2014. Thesis, University of the Western Cape. Accessed April 13, 2021. http://hdl.handle.net/11394/3904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Egunlusi, Ayodeji Olatunde. “Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection .” 2014. Web. 13 Apr 2021.

Vancouver:

Egunlusi AO. Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection . [Internet] [Thesis]. University of the Western Cape; 2014. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/11394/3904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Egunlusi AO. Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection . [Thesis]. University of the Western Cape; 2014. Available from: http://hdl.handle.net/11394/3904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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