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You searched for subject:( Proteinas desacopladoras). One record found.

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Universidade Estadual de Campinas

1. Lutaif, Nelson Afonso. Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation.

Degree: 2007, Universidade Estadual de Campinas

Abstract: Introduction: Human kidneys are responsible for 10% of whole oxygen consumed in 24 hours as a result may have a great contribution in human global thermogenesis. Global thermogenesis which is related with mitochondrial oxygen consumption. We assumed that renal injuries necessarily promotes disturbances on global thermogenesis and consequently promote a re-adaptation on facultative and obligatory thermogenesis. To investigate the renal contribution on maintenance of internal temperature, we studied Sprague Dawley rats with: (Nx) mass reduction, (Dx) denervation and (Ox) urinary tract obstruction and two controls group: sham and (Non) no-operative. Methods: The study was performed after animals¿ immersions in warm water to avoid temperature dissipation and rectal temperature was recorded. Obligatory thermogenesis was evaluated through mitochondria respiratory chain and ADP/0 ratio in hepatocytes. The UCP1 and pathways associated with glucose captation (IRS1, PI3K, AKT1 and ERK1,2) protein expression in brow adipose tissue was studied by western blot method. Results: The Nx group presented significant initial lower temperature than Dx group: 36.14±0.8083°C x 37.15±0.9601 °C, with p<0.05. After thirty minutes, Dx group presented significant higher temperature (40.38 °C) than Sham (39.09±0.21°C), Nx (36.14±0.8083°C) and Ox (37.22±0.4338°C), groups with p<0.05. The Dx group showed significant higher thermal slope curve values (0.05836±0.07683) than Sham (0.04238±0.006312), Non (0.05182 ± 0.05546) and Ox (0.04516±0.005107) with p<0.05. Also, the area under curve presented Nx group with significant higher values (57.05 ± 17.82) than Ox (35.61±7.792), Sham (41.03 ± 3.06) and Non (39.82 ± 5.848) with p<0.001. No statistical difference was observed between all groups when the mitochondrial oxygen consumption and ADP/0 ratio were studied. The Dx and Nx groups showed increase in UCP1 and AKT1 activities. Conclusions: These results suggest that kidneys may play important function on body thermoregulation, contributing to thermal generation with own metabolic activities. We also concluded that renal nerves activity plays a role in thermic homeostase control, working associated with central nervous system and brown adipose tissue Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Gontijo, Jose Antonio Rocha, 1956- (advisor), Gontijo, José Antonio da Rocha (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Fisiopatologia Médica (nameofprogram), Barros, Rui Toledo de (committee member), Burdman, Emanuel de Almeida (committee member), Rocha, Eduardo Melani (committee member), Homsi, Eduardo (committee member).

Subjects/Keywords: Termogenese; Proteinas desacopladoras; Homeostase; Insuficiência renal; Thermogenesis; Uncoupling proteins; Energy transfer; Renal insuficiency

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APA (6th Edition):

Lutaif, N. A. (2007). Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/309922

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lutaif, Nelson Afonso. “Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation.” 2007. Thesis, Universidade Estadual de Campinas. Accessed September 21, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309922.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lutaif, Nelson Afonso. “Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation.” 2007. Web. 21 Sep 2020.

Vancouver:

Lutaif NA. Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation. [Internet] [Thesis]. Universidade Estadual de Campinas; 2007. [cited 2020 Sep 21]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309922.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lutaif NA. Contribuição renal para a homeostase corporal em ratos : função da inervação renal: Renal contributions to corporal homeostasis in rats : role of renal innervation. [Thesis]. Universidade Estadual de Campinas; 2007. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/309922

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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