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Tulane University
1.
Lee, Kim.
Context-dependent astrocyte activation and remodeling in CNS disease.
Degree: 2017, Tulane University
URL: https://digitallibrary.tulane.edu/islandora/object/tulane:75501 
► Astrocytes are the most numerous nonneuronal cell-type within the brain. These glial cells support activities essential for neuronal function, regulating extracellular concentrations of ions and…
(more)
▼ Astrocytes are the most numerous nonneuronal cell-type within the brain. These glial cells support activities essential for neuronal function, regulating extracellular concentrations of ions and neurotransmitters, providing metabolic substrates, and maintaining the blood-brain barrier. In addition, astrocytes respond to central nervous system (CNS) disease by becoming reactive, a nonspecific but highly characteristic response that involves various molecular and morphological changes. Quantifiable changes in astrocyte activation and remodeling have been documented in chronic stress, neurodegenerative disease, mood disorders, and CNS infections. However, whether astrocytes remodel in the same way and whether all insults produce the same effect is largely unknown. Here, studies examine astrocyte morphology and immune activation in nonhuman primates across a wide range of CNS diseases including bacterial and viral infection, and self-injurious behaviors.
Paraffin-embedded tissue was selected from the Tulane National Primate Research Center archives, and immunofluorescence with TLR2 and GFAP was used to examine immune activation of astrocytes in cortical tissue. In addition, reconstruction of astrocyte morphology using Neurolucida software revealed specific remodeling patterns for each CNS disease state. While immune activation through Toll-like receptor and GFAP expression generally increased in pathological states, specific astrocyte remodeling patterns were observed relative to pathology indicating that astrocyte response to CNS disease is dependent upon cortical location and pathological state.
1
Kim Lee
Advisors/Committee Members: MacLean, Andrew (Thesis advisor), School of Medicine Biomedical Sciences Graduate Program (Degree granting institution).
Subjects/Keywords: nonhuman primate
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APA (6th Edition):
Lee, K. (2017). Context-dependent astrocyte activation and remodeling in CNS disease. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:75501
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lee, Kim. “Context-dependent astrocyte activation and remodeling in CNS disease.” 2017. Thesis, Tulane University. Accessed January 16, 2021.
https://digitallibrary.tulane.edu/islandora/object/tulane:75501.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lee, Kim. “Context-dependent astrocyte activation and remodeling in CNS disease.” 2017. Web. 16 Jan 2021.
Vancouver:
Lee K. Context-dependent astrocyte activation and remodeling in CNS disease. [Internet] [Thesis]. Tulane University; 2017. [cited 2021 Jan 16].
Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75501.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lee K. Context-dependent astrocyte activation and remodeling in CNS disease. [Thesis]. Tulane University; 2017. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75501
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Edinburgh
2.
Mitchell, Clare.
Personality in ring-tailed lemurs (Lemur catta): Investigating factor structure, and relationships with stress, grooming, and dominance.
Degree: 2008, University of Edinburgh
URL: http://hdl.handle.net/1842/2872
► Examining personality in non-human primates provides a useful tool for understanding evolutionary bases. The following research focused on exploring the personality of captive ring-tailed lemurs,…
(more)
▼ Examining personality in non-human primates provides a useful tool for understanding evolutionary bases. The following research focused on exploring the personality of captive ring-tailed lemurs, and its relationship with audience-related stress, grooming, and the ability to gain dominance. Seven females and two males at Edinburgh Zoo were observed for 12 weeks. Personality ratings were made by researchers and zoo keepers. Behavioural observations were made while recording the size and activity of the audience present, and duration of grooming was also sampled. Rank was assessed by net wins in agonistic interactions. Four personality factors were extracted: Dominance, Neuroticism-low Conscientiousness, Extraversion, and Agreeableness. Despite factor names, there was a large discrepancy with human dimensions, suggesting they are relics of early
primate personality. Regarding audience effects, a larger audience was associated with fewer affiliative behaviours, and an increase in activity. There was no firm evidence to conclude visitors were disconcerting, however differences in Agreeableness influenced how the lemurs reacted to an audience. Scores on Extraversion were positively correlated with duration of received grooming, and Extraversion, Dominance, and Agreeableness scores were all positively associated with rank. Future research must focus on fully investigating the links between personality and stress, to identify high risk individuals in captivity.
Advisors/Committee Members: Weiss, Alexander.
Subjects/Keywords: Personality; Zoo; Primate; Grooming
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APA (6th Edition):
Mitchell, C. (2008). Personality in ring-tailed lemurs (Lemur catta): Investigating factor structure, and relationships with stress, grooming, and dominance. (Thesis). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/2872
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mitchell, Clare. “Personality in ring-tailed lemurs (Lemur catta): Investigating factor structure, and relationships with stress, grooming, and dominance.” 2008. Thesis, University of Edinburgh. Accessed January 16, 2021.
http://hdl.handle.net/1842/2872.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mitchell, Clare. “Personality in ring-tailed lemurs (Lemur catta): Investigating factor structure, and relationships with stress, grooming, and dominance.” 2008. Web. 16 Jan 2021.
Vancouver:
Mitchell C. Personality in ring-tailed lemurs (Lemur catta): Investigating factor structure, and relationships with stress, grooming, and dominance. [Internet] [Thesis]. University of Edinburgh; 2008. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1842/2872.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mitchell C. Personality in ring-tailed lemurs (Lemur catta): Investigating factor structure, and relationships with stress, grooming, and dominance. [Thesis]. University of Edinburgh; 2008. Available from: http://hdl.handle.net/1842/2872
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Edinburgh
3.
Fleming, Camille.
Personality in Captive Ring-tailed Lemurs (Lemur Catta): Trait Structure and the Interaction with Dominance Hierarchy and Zoo Visitor Effects.
Degree: 2008, University of Edinburgh
URL: http://hdl.handle.net/1842/2871
► Personality ratings for a captive group of ring-tailed lemurs were obtained and factor analysis revealed four personality factors labelled Dominance, High Neuroticism/Low Conscientiousness, Extraversion and…
(more)
▼ Personality ratings for a captive group of ring-tailed lemurs were obtained and factor analysis revealed four personality factors labelled Dominance, High Neuroticism/Low Conscientiousness, Extraversion and Agreeableness. The study also explored whether grooming behaviour could be used as a dominance index and results indicated that higher-ranking lemurs were less likely to initiate grooming to other lemurs. Correlations between grooming behaviour and the personality factors indicated that Extraversion was correlated with average grooming received and High Neuroticism/Low Neuroticism was correlated with average grooming initiated. Finally, zoo visitor effects were examined and significant effects were found for audience size on locomotion and affiliative behaviour and there was an interaction between audience size and audience activity for agonisic behaviours. Correlations between these behaviours and the personality factors revealed a significant relationship between Agreeableness and agonistic behaviour. As the study is the first known exploration in to lemur personality, future research on other samples of lemurs is needed to discover if the personality factor structure is stable across different environments.
Advisors/Committee Members: Weiss, Alexander.
Subjects/Keywords: primate; personality; zoo; grooming
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APA (6th Edition):
Fleming, C. (2008). Personality in Captive Ring-tailed Lemurs (Lemur Catta): Trait Structure and the Interaction with Dominance Hierarchy and Zoo Visitor Effects. (Thesis). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/2871
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fleming, Camille. “Personality in Captive Ring-tailed Lemurs (Lemur Catta): Trait Structure and the Interaction with Dominance Hierarchy and Zoo Visitor Effects.” 2008. Thesis, University of Edinburgh. Accessed January 16, 2021.
http://hdl.handle.net/1842/2871.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fleming, Camille. “Personality in Captive Ring-tailed Lemurs (Lemur Catta): Trait Structure and the Interaction with Dominance Hierarchy and Zoo Visitor Effects.” 2008. Web. 16 Jan 2021.
Vancouver:
Fleming C. Personality in Captive Ring-tailed Lemurs (Lemur Catta): Trait Structure and the Interaction with Dominance Hierarchy and Zoo Visitor Effects. [Internet] [Thesis]. University of Edinburgh; 2008. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1842/2871.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fleming C. Personality in Captive Ring-tailed Lemurs (Lemur Catta): Trait Structure and the Interaction with Dominance Hierarchy and Zoo Visitor Effects. [Thesis]. University of Edinburgh; 2008. Available from: http://hdl.handle.net/1842/2871
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Tulane University
4.
LoBato, Denae N.
Development, validation, and use of a semi-quantitative histopathologic scoring system for assessment of pulmonary pathology in Rhesus macaques experimentally infected with Mycobacterium tuberculosis.
Degree: 2019, Tulane University
URL: https://digitallibrary.tulane.edu/islandora/object/tulane:87923
► [email protected]
Mycobacterium tuberculosis (Mtb) remains the single largest infectious disease killer of man worldwide. The non-human primate (NHP) model, including the Indian Rhesus macaque, is…
(more)
▼ [email protected]
Mycobacterium tuberculosis (Mtb) remains the single largest infectious disease killer of man worldwide. The non-human primate (NHP) model, including the Indian Rhesus macaque, is particularly valuable for the study of this disease because they fully recapitulate the pathological and immunological responses, can be co-infected with Simian Immunodeficiency Virus to model lentivirus synergism, and provide ideal candidates to study novel vaccine and drug development. However, while much has been elucidated over the past centuries in regards to host immunity, bacterial responses, and granuloma formation, little remains known about histomorphologic differences between active tuberculosis (ATBI) and latent tuberculosis (ATBI) disease states. Differentiation between these disease states, in humans or in NHPs, is based on clinical parameters, and there are currently no established methods for detecting morphologic differences between these conditions at the microscopic level. The aim of this study was to develop and validate a novel approach for assessment of pulmonary pathology in Rhesus macaques experimentally-infected with M. tuberculosis alone or in the setting of SIV co-infection. Archival lung samples from experimentally-infected macaques were assessed by blinded pathologists to determine differences in a series of pathological parameters based on previous experiments. Interobserver agreement and repeatability was good between pathologists. Significant differences were observed in several pathology categories, with ATBI animals having a greater likelihood of increased alveolar macropahges, type II pneumocyte hyperplasia, perivasculitis, vasculitis/lymphangitis, and consolidation in comparison to LTBI animals. SIV co-infection increased the likelihood of perivasculitis and lymphangitis/vasculitis in both ATBI and LTBI animals. SIV co-infection also increased alveolar macrophages and type II pneumocyte hyperplasia in LTBI animals. Immunofluorescence was used to confirm the presence of Mtb bacilli within the perivascular inflammation. A similar grading system approach was used in 2 additional studies examining reactivation of ATBI in the setting of SIV coinfection unrelated to CD4+ T cell depletion and to evaluate pulmonary pathology changes in the setting of the use of an attenuated vaccine in SIV co-infected animals with similarly significant results. This grading scheme provides a valuable and desperately needed adjunctive assessment tool for evaluation of pulmonary pathology changes in the NHP model of pulmonary tuberculosis.
1
Denae N. LoBato
Advisors/Committee Members: Kaushal, Deepak (Thesis advisor), School of Medicine Biomedical Sciences Graduate Program (Degree granting institution), NULL (Degree granting institution).
Subjects/Keywords: Tuberculosis; Non-human Primate; Pathology
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APA (6th Edition):
LoBato, D. N. (2019). Development, validation, and use of a semi-quantitative histopathologic scoring system for assessment of pulmonary pathology in Rhesus macaques experimentally infected with Mycobacterium tuberculosis. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:87923
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
LoBato, Denae N. “Development, validation, and use of a semi-quantitative histopathologic scoring system for assessment of pulmonary pathology in Rhesus macaques experimentally infected with Mycobacterium tuberculosis.” 2019. Thesis, Tulane University. Accessed January 16, 2021.
https://digitallibrary.tulane.edu/islandora/object/tulane:87923.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
LoBato, Denae N. “Development, validation, and use of a semi-quantitative histopathologic scoring system for assessment of pulmonary pathology in Rhesus macaques experimentally infected with Mycobacterium tuberculosis.” 2019. Web. 16 Jan 2021.
Vancouver:
LoBato DN. Development, validation, and use of a semi-quantitative histopathologic scoring system for assessment of pulmonary pathology in Rhesus macaques experimentally infected with Mycobacterium tuberculosis. [Internet] [Thesis]. Tulane University; 2019. [cited 2021 Jan 16].
Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:87923.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
LoBato DN. Development, validation, and use of a semi-quantitative histopathologic scoring system for assessment of pulmonary pathology in Rhesus macaques experimentally infected with Mycobacterium tuberculosis. [Thesis]. Tulane University; 2019. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:87923
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
5.
Miller, Daniel James.
Quantitative Analysis of the Evolution and Reorganization of Microstructure in Primates.
Degree: PhD, Psychology, 2017, Vanderbilt University
URL: http://hdl.handle.net/1803/13821
► One of the primary goals in neuroscience is to elucidate the relationship between the structure and function of the brain, and yet basic information about…
(more)
▼ One of the primary goals in neuroscience is to elucidate the relationship between the structure and function of the brain, and yet basic information about the anatomy of specific circuits is often unavailable. Primates exhibit a suite of adaptations for visual predation, and the sense of touch is fundamental to the proprioception that enables smooth, coordinated movement. In this dissertation, we investigated the visual system in a sample of primates adapted to diurnal or nocturnal ecologies in order to identify anatomical changes associated with vision in conditions of high or low levels of light, respectively. In addition, we investigated reorganization of the brainstem following spinal cord injury in order to determine the effect of the timing and extent of injury on anatomical changes supporting the sense of touch. Our major findings indicate a mosaic of changes in visual cortex microstructure across
primate evolution that is broadly correlated with visual acuity and behavioral foraging ecology, and we also show the differential effect of the timing of injury upon regional and neuronal atrophy in the cuneate nucleus following deafferentation. Together, these observations provide initial indices of the structural requirements associated with broad changes in visual behavior and the anatomical changes that follow spinal cord injury.
Advisors/Committee Members: Troy Hackett (committee member), Anita Disney (committee member), Jon H Kaas (committee member), Geoffrey Woodman (Committee Chair).
Subjects/Keywords: primate; stereology; cuneate; V1; evolution
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APA (6th Edition):
Miller, D. J. (2017). Quantitative Analysis of the Evolution and Reorganization of Microstructure in Primates. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13821
Chicago Manual of Style (16th Edition):
Miller, Daniel James. “Quantitative Analysis of the Evolution and Reorganization of Microstructure in Primates.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed January 16, 2021.
http://hdl.handle.net/1803/13821.
MLA Handbook (7th Edition):
Miller, Daniel James. “Quantitative Analysis of the Evolution and Reorganization of Microstructure in Primates.” 2017. Web. 16 Jan 2021.
Vancouver:
Miller DJ. Quantitative Analysis of the Evolution and Reorganization of Microstructure in Primates. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1803/13821.
Council of Science Editors:
Miller DJ. Quantitative Analysis of the Evolution and Reorganization of Microstructure in Primates. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/13821
University of Utah
6.
Federer, Frederick.
Four projection streams from primate v1 to the cytochrome oxidase stripes of v2.
Degree: PhD, Neurology, 2010, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2057/rec/510
► In the primate visual system, areas V1 and V2 distribute information they receive from the retina to all higher cortical areas, sorting this information into…
(more)
▼ In the primate visual system, areas V1 and V2 distribute information they receive from the retina to all higher cortical areas, sorting this information into dorsal and ventral streams. Therefore, knowledge of the organization of projections between V1 and V2 is crucial to understand how the cortex processes visual information. In primates, parallel output pathways from V1 project to distinct V2 stripes. The traditional tripartite division of V1-to-V2 projections was recently replaced by a bipartite scheme, in which thin stripes receive V1 inputs from blob columns, and thick and pale stripes receive common input from interblob columns. Here we demonstrate that thick and pale stripes, instead, receive spatially segregated V1 inputs, and that the interblob is partitioned into two compartments: the middle of the interblob projecting to pale stripes, and the blob/interblob border region projecting to thick stripes. Double-labeling experiments further demonstrate that V1 cells project to either thick or pale stripes, but rarely to both. We also find laminar specialization of V1 outputs, with layer 4B contributing projections mainly to thick stripes, and no projections to one set of pale stripes. These laminar differences suggest different contribution of magno, parvo and konio inputs to each V1 output pathway. These results provide a new foundation for parallel processing models of the visual system by demonstrating four V1-to-V2 pathways: blob columns-to-thin stripes, blob/interblob border columns-to-thick stripes, interblob columns-to-palelateral stripes, layer 2/3-4A interblobs-to-palemedial stripes.
Subjects/Keywords: Primate; V1; V2; Primate visual system; Projection streams
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APA (6th Edition):
Federer, F. (2010). Four projection streams from primate v1 to the cytochrome oxidase stripes of v2. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2057/rec/510
Chicago Manual of Style (16th Edition):
Federer, Frederick. “Four projection streams from primate v1 to the cytochrome oxidase stripes of v2.” 2010. Doctoral Dissertation, University of Utah. Accessed January 16, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2057/rec/510.
MLA Handbook (7th Edition):
Federer, Frederick. “Four projection streams from primate v1 to the cytochrome oxidase stripes of v2.” 2010. Web. 16 Jan 2021.
Vancouver:
Federer F. Four projection streams from primate v1 to the cytochrome oxidase stripes of v2. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Jan 16].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2057/rec/510.
Council of Science Editors:
Federer F. Four projection streams from primate v1 to the cytochrome oxidase stripes of v2. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2057/rec/510
7.
Poirotte, Clémence.
Stratégies d’évitement parasitaire chez une population de primates sociaux en milieu naturel : Parasite avoidance strategies in a natural population of a social primate.
Degree: Docteur es, Sciences de l'évolution et de la biodiversité, 2016, Montpellier
URL: http://www.theses.fr/2016MONTT166
► Les pressions de sélection exercées par les parasites ont permis l’évolution de mécanismes complexes de défense chez les espèces hôtes qui limitent la transmission parasitaire.…
(more)
▼ Les pressions de sélection exercées par les parasites ont permis l’évolution de mécanismes complexes de défense chez les espèces hôtes qui limitent la transmission parasitaire. En complément de leur système immunitaire physiologique, les animaux ont développé un « système immunitaire comportemental » comprenant un ensemble sophistiqué de stratégies d’évitement parasitaire représentant une première ligne de défense pour diminuer la probabilité de rencontre avec différents parasites. Cependant, ces stratégies comportementales n’ont été que peu étudiées chez les espèces de mammifères vivant en milieu naturel. Au cours de ma thèse, j’ai donc étudié les stratégies d’évitement parasitaire dans une population sauvage de mandrills (Mandrillus sphinx), un primate de l’Ancien Monde vivant dans les forêts denses équatoriales d’Afrique et soumis à de forces pressions parasitaires. Je me suis en particulier intéressée aux différentes stratégies comportementales qui ont évolué en réponse au risque de contamination par deux types distincts de parasites gastro-intestinaux présentant des traits d’histoire de vie et des modes de transmission contrastés : les nématodes, transmis par l’environnement, et les protozoaires, transmis par contacts sociaux. A partir d’observations récoltées sur le long-terme, de test expérimentaux et d’analyses chimiques, mes études ont mis en évidence deux stratégies comportementales différentes, soulignant le lien étroit entre l’écologie des parasites et la réponse comportementale des hôtes. D’une part, les mandrills évitent les matières fécales lorsqu’ils fourragent et évitent également les habitats précédemment contaminés par des nématodes fécaux émis lors de la dernière visite de ces habitats. D’autre part, les mandrills évitent de toiletter leurs partenaires sociaux parasités par des protozoaires fécaux, particulièrement autour de la zone anale. Cette stratégie comportementale s’avère être efficace puisque les individus parasités présentent des kystes infectieux de protozoaires sur leurs corps, concentrés au niveau de la zone anale, et la richesse en protozoaire des individus augmente lorsqu’ils toilettent des congénères très parasités. De plus, nous avons montré que cet évitement des individus parasités était guidé par un mécanisme olfactif : les protozoaires influencent l’odeur des matières fécales et les individus discriminent et évitent l’odeur des matières fécales provenant d’individus parasités. Cette plasticité comportementale face au risque parasitaire pourrait constituer un des mécanismes majeurs permettant aux espèces sociales de diminuer le risque accru de contamination associé à la vie en groupe. L’ensemble de nos résultats permettent de mieux appréhender les conséquences évolutives des pressions de sélection exercées par les parasites sur différentes caractéristiques socio-écologiques des animaux, tels que l’utilisation de l’espace et les comportements sociaux.
Parasite-mediated selection has driven the emergence of complex hosts’ defense mechanisms to limit the spread of parasites. In…
Advisors/Committee Members: Charpentier, Marie (thesis director).
Subjects/Keywords: Écologie comportementale; Parasitisme; Primate; Behavioral ecology; Parasitism; Primate
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APA ·
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MLA ·
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Manager
APA (6th Edition):
Poirotte, C. (2016). Stratégies d’évitement parasitaire chez une population de primates sociaux en milieu naturel : Parasite avoidance strategies in a natural population of a social primate. (Doctoral Dissertation). Montpellier. Retrieved from http://www.theses.fr/2016MONTT166
Chicago Manual of Style (16th Edition):
Poirotte, Clémence. “Stratégies d’évitement parasitaire chez une population de primates sociaux en milieu naturel : Parasite avoidance strategies in a natural population of a social primate.” 2016. Doctoral Dissertation, Montpellier. Accessed January 16, 2021.
http://www.theses.fr/2016MONTT166.
MLA Handbook (7th Edition):
Poirotte, Clémence. “Stratégies d’évitement parasitaire chez une population de primates sociaux en milieu naturel : Parasite avoidance strategies in a natural population of a social primate.” 2016. Web. 16 Jan 2021.
Vancouver:
Poirotte C. Stratégies d’évitement parasitaire chez une population de primates sociaux en milieu naturel : Parasite avoidance strategies in a natural population of a social primate. [Internet] [Doctoral dissertation]. Montpellier; 2016. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2016MONTT166.
Council of Science Editors:
Poirotte C. Stratégies d’évitement parasitaire chez une population de primates sociaux en milieu naturel : Parasite avoidance strategies in a natural population of a social primate. [Doctoral Dissertation]. Montpellier; 2016. Available from: http://www.theses.fr/2016MONTT166
University of Colorado
8.
Whitelaw, Dana Carrie.
Ecological Impacts of Forest Disturbance on Ring-Tailed Lemurs (Lemur Catta) in the Beza-Mahafaly Special Reserve Region: Implications for Conservation in an Altered Landscape.
Degree: PhD, Anthropology, 2010, University of Colorado
URL: https://scholar.colorado.edu/anth_gradetds/3
► Forest disturbance, both natural and anthropogenic, has been recognized as a severe threat to primate populations on a global scale. Moreover, primates tend to…
(more)
▼ Forest disturbance, both natural and anthropogenic, has been recognized as a severe threat to
primate populations on a global scale. Moreover, primates tend to vary, between species and between sites, in their tolerance and response to disturbances. Perhaps because of this variability, the effects of ecological perturbations on primates remain relatively poorly understood. Understanding disturbance effects and the ecological variables that are particularly potent for primates will provide sound data for effective conservation management. In this dissertation, I examine the effects of anthropogenic disturbance and a destructive cyclone on the ecology and behavior of the ring-tailed lemur (
Lemur catta) at Beza Mahafaly Special Reserve in southwestern Madagascar. I present data from four study groups (two in the protected Reserve and two in anthropogenically disturbed, unprotected habitats). Cyclone Ernest affected this region when it made landfall in January of 2005, seven months prior to the beginning of this study. These natural and anthropogenic disturbances have altered forest structure and phenology. Groups inside the Reserve tend to eat more terrestrial herbs and vine leaves.
Additionally, Reserve Groups also rely on a fewer number of species for the majority of their diet. It appears that in more marginal habitats,
L. catta is able to diversify its diet and exploit foods that might not be their primary choice. Non-Reserve Groups also inhabited smaller home ranges, but had higher daily path lengths than groups residing in the Reserve. Additionally, Non-Reserve Groups utilize open canopy areas and habitats with higher degrees of disturbance to a greater extent than Reserve Groups. Non-Reserve Groups spend more of their active time both feeding and traveling than groups inside the Reserve. Non-Reserve Groups devoted less of their time to resting compared to Reserve Groups. Groups in unprotected habitats have greatly reduced group cohesion, lower rates of grooming, and elevated levels of aggression. Preliminary data show higher rates of injury and mortality for groups living outside of the protected forest. Anthropogenic habitat alterations, coupled with stochastic changes from tropical storms, have changed the landscape both in and around BMSR and contributed to survival challenges for
L. catta in the area.
Advisors/Committee Members: Michelle L. Sauther, Herbert Covert, David Armstrong.
Subjects/Keywords: Lemur Catta; Madagascar; Primate Biology; Primate Conservation; Primate Ecology; Ring-Tailed Lemur; Animal Sciences; Ecology and Evolutionary Biology; Forest Sciences; Zoology
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APA (6th Edition):
Whitelaw, D. C. (2010). Ecological Impacts of Forest Disturbance on Ring-Tailed Lemurs (Lemur Catta) in the Beza-Mahafaly Special Reserve Region: Implications for Conservation in an Altered Landscape. (Doctoral Dissertation). University of Colorado. Retrieved from https://scholar.colorado.edu/anth_gradetds/3
Chicago Manual of Style (16th Edition):
Whitelaw, Dana Carrie. “Ecological Impacts of Forest Disturbance on Ring-Tailed Lemurs (Lemur Catta) in the Beza-Mahafaly Special Reserve Region: Implications for Conservation in an Altered Landscape.” 2010. Doctoral Dissertation, University of Colorado. Accessed January 16, 2021.
https://scholar.colorado.edu/anth_gradetds/3.
MLA Handbook (7th Edition):
Whitelaw, Dana Carrie. “Ecological Impacts of Forest Disturbance on Ring-Tailed Lemurs (Lemur Catta) in the Beza-Mahafaly Special Reserve Region: Implications for Conservation in an Altered Landscape.” 2010. Web. 16 Jan 2021.
Vancouver:
Whitelaw DC. Ecological Impacts of Forest Disturbance on Ring-Tailed Lemurs (Lemur Catta) in the Beza-Mahafaly Special Reserve Region: Implications for Conservation in an Altered Landscape. [Internet] [Doctoral dissertation]. University of Colorado; 2010. [cited 2021 Jan 16].
Available from: https://scholar.colorado.edu/anth_gradetds/3.
Council of Science Editors:
Whitelaw DC. Ecological Impacts of Forest Disturbance on Ring-Tailed Lemurs (Lemur Catta) in the Beza-Mahafaly Special Reserve Region: Implications for Conservation in an Altered Landscape. [Doctoral Dissertation]. University of Colorado; 2010. Available from: https://scholar.colorado.edu/anth_gradetds/3
9.
Remington, Evan Douglas.
PHYSIOLOGICAL AND BEHAVIORAL STUDIES OF SOUND LOCATION PROCESSING IN AUDITORY CORTEX OF THE MARMOSET MONKEY.
Degree: 2013, Johns Hopkins University
URL: http://jhir.library.jhu.edu/handle/1774.2/37004
► For many animals, the ability to localize sound sources provides a key source of information about the objects and events in the world around them.…
(more)
▼ For many animals, the ability to localize sound sources provides a key source of information about the objects and events in the world around them. Unlike visual information, sound is not easily occluded by physical objects, and can reach the sensory epithelia from any direction, day and night. Integration of sound localization cues first occurs well below the level of auditory cortex, yet it has been well documented that auditory cortex is required for many behaviors requiring sound localization. However, the nature of spatial representation and computation in auditory cortex remains incompletely understood. This is may be due in part to the lack of studies which have measured responses from the full spatial field, and also to the lack of studies in awake, behaving animals. In this thesis, we present data from neurons in primary auditory cortex (A1), the rostral core areas (R/RT), and the caudal belt (CM/CL) of awake marmoset monkeys (Callithrix jacchus) responding to
broadband sounds presented from the full spatial field. The marmoset is a well established model system for the study of auditory processing and is an arboreal animal for which spatial processing is vital in its natural habitat, making it an ideal candidate for the study of spatial processing in auditory cortex. It was found that distributions of spatial receptive fields were highly heterogeneous, with neurons tuned to contralateral and ipsilateral locations, above and below the horizon, and in the rear as well as the frontal locations. Receptive field statistics varied between areas, with the caudal areas showing the most spatial selectivity, but spatial tuning was observed in neurons from all areas recorded. We also introduced a novel approach to characterize spatial tuning in a multi-source acoustic environment by presenting sounds from all sound sources simultaneously. Using this method it was found that most neurons exhibit drastically different spatial tuning in a multi-source
environment compared to the single source condition, probably reflecting highly nonlinear mechanisms underlying spatial processing. Further, we describe an auditory operant conditioning task developed in this thesis in which marmosets can be trained easily and generalize between stimulus types. This task was used to measure spatial hearing acuity (minimum audible angle) for azimuth and elevation, and found marmosets to be have acuity roughly as expected based on head size. This task is ideal for use in both head-fixed and head-free restrained neural recordings; when comparing neural responses the location discrimination task to those measured while marmosets sat passively, a subset of neurons was found with increased firing rates to one or more target locations during task engagement. Effects were similar across areas, but were largest in the caudal areas CM/CL. Together, these results suggest that spatial tuning auditory cortex of awake, behaving animals is highly selective and can
be dynamically modulated to accommodate specific task demands.
Advisors/Committee Members: May, Bradford (advisor).
Subjects/Keywords: sound localization;
auditory cortex;
nonhuman primate
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APA (6th Edition):
Remington, E. D. (2013). PHYSIOLOGICAL AND BEHAVIORAL STUDIES OF SOUND LOCATION PROCESSING IN AUDITORY CORTEX OF THE MARMOSET MONKEY. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/37004
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Remington, Evan Douglas. “PHYSIOLOGICAL AND BEHAVIORAL STUDIES OF SOUND LOCATION PROCESSING IN AUDITORY CORTEX OF THE MARMOSET MONKEY.” 2013. Thesis, Johns Hopkins University. Accessed January 16, 2021.
http://jhir.library.jhu.edu/handle/1774.2/37004.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Remington, Evan Douglas. “PHYSIOLOGICAL AND BEHAVIORAL STUDIES OF SOUND LOCATION PROCESSING IN AUDITORY CORTEX OF THE MARMOSET MONKEY.” 2013. Web. 16 Jan 2021.
Vancouver:
Remington ED. PHYSIOLOGICAL AND BEHAVIORAL STUDIES OF SOUND LOCATION PROCESSING IN AUDITORY CORTEX OF THE MARMOSET MONKEY. [Internet] [Thesis]. Johns Hopkins University; 2013. [cited 2021 Jan 16].
Available from: http://jhir.library.jhu.edu/handle/1774.2/37004.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Remington ED. PHYSIOLOGICAL AND BEHAVIORAL STUDIES OF SOUND LOCATION PROCESSING IN AUDITORY CORTEX OF THE MARMOSET MONKEY. [Thesis]. Johns Hopkins University; 2013. Available from: http://jhir.library.jhu.edu/handle/1774.2/37004
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
10.
Turner, Emily Claire.
Visual Neuroanatomy of Large-Brained Primates and Carnivores.
Degree: PhD, Psychology, 2017, Vanderbilt University
URL: http://hdl.handle.net/1803/11720
► Efforts to understand the evolution of modern mammalian brains are undertaken through comparative studies of cortical organization. Here, we have used a comparative approach in…
(more)
▼ Efforts to understand the evolution of modern mammalian brains are undertaken through comparative studies of cortical organization. Here, we have used a comparative approach in studying multiple species to understand more about the organization of the visual system across different mammalian orders. Primates are notable for their large brains, and every
primate species has an average brain size larger than then 0.4 g mouse brain, the animal model most commonly used in laboratory studies. Neurons are the building blocks of neocortex, and an accurate estimate of the total number of neurons in a brain can reveal information concerning the specializations of cortex. In this collaborative effort, we determined the total numbers of cells and neurons within the neocortex of the adult chimpanzee and macaque brains. These are species that have relatively large brains compared to most mammals, and to the proposed brain size of our earliest mammalian ancestors. We found the same pattern of overall neuronal density described in all other
primate species, in which primary visual cortex and primary somatosensory cortex contain higher-than-average neuron densities and primary motor cortex contains lower-than-average neuron densities. It is also important to look to species that also, independently of the
primate lineage, came to evolve large brains. As such, we examined the visual neuroanatomy of the California sea lion and northern elephant seal using immunohistochemistry in coronal sections and other reconstruction methods. We found that the visual neuroanatomy is more similar in structure to other carnivores, such as cats, as opposed to primates, which is expected given these species’ phylogenetic position within the Carnivora order.
Advisors/Committee Members: Anita Disney (committee member), Isabel Gauthier (committee member), Troy Hackett (committee member), Jon Kaas (Committee Chair).
Subjects/Keywords: pinniped; neuron density; visual cortex; neocortex; primate
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APA (6th Edition):
Turner, E. C. (2017). Visual Neuroanatomy of Large-Brained Primates and Carnivores. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11720
Chicago Manual of Style (16th Edition):
Turner, Emily Claire. “Visual Neuroanatomy of Large-Brained Primates and Carnivores.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed January 16, 2021.
http://hdl.handle.net/1803/11720.
MLA Handbook (7th Edition):
Turner, Emily Claire. “Visual Neuroanatomy of Large-Brained Primates and Carnivores.” 2017. Web. 16 Jan 2021.
Vancouver:
Turner EC. Visual Neuroanatomy of Large-Brained Primates and Carnivores. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1803/11720.
Council of Science Editors:
Turner EC. Visual Neuroanatomy of Large-Brained Primates and Carnivores. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/11720
Queens University
11.
Olesovsky, Shelby.
Robotic Outcome Assessment in a Non-Human Primate Model of Middle Cerebral Artery Stroke
.
Degree: Neuroscience Studies, 2016, Queens University
URL: http://hdl.handle.net/1974/14459
► Stroke is a prevalent disorder with immense socioeconomic impact. A variety of chronic neurological deficits result from stroke. In particular, sensorimotor deficits are a significant…
(more)
▼ Stroke is a prevalent disorder with immense socioeconomic impact. A variety of chronic neurological deficits result from stroke. In particular, sensorimotor deficits are a significant barrier to achieving post-stroke independence. Unfortunately, the majority of pre-clinical studies that show improved outcomes in animal stroke models have failed in clinical trials. Pre-clinical studies using non-human primate (NHP) stroke models prior to initiating human trials are a potential step to improving translation from animal studies to clinical trials. Robotic assessment tools represent a quantitative, reliable, and reproducible means to assess reaching behaviour following stroke in both humans and NHPs. We investigated the use of robotic technology to assess sensorimotor impairments in NHPs following middle cerebral artery occlusion (MCAO). Two cynomolgus macaques underwent transient MCAO for 90 minutes. Approximately 1.5 years following the procedure these NHPs and two non-stroke control monkeys were trained in a reaching task with both arms in the KINARM exoskeleton. This robot permits elbow and shoulder movements in the horizontal plane. The task required NHPs to make reaching movements from a centrally positioned start target to 1 of 8 peripheral targets uniformly distributed around the first target. We analyzed four movement parameters: reaction time, movement time (MT), initial direction error (IDE), and number of speed maxima to characterize sensorimotor deficiencies. We hypothesized reduced performance in these attributes during a neurobehavioural task with the paretic limb of NHPs following MCAO compared to controls.
Reaching movements in the non-affected limbs of control and experimental NHPs showed bell-shaped velocity profiles. In contrast, the reaching movements with the affected limbs were highly variable. We found distinctive patterns in MT, IDE, and number of speed peaks between control and experimental monkeys and between limbs of NHPs with MCAO. NHPs with MCAO demonstrated more speed peaks, longer MTs, and greater IDE in their paretic limb compared to controls. These initial results qualitatively match human stroke subjects’ performance, suggesting that robotic neurobehavioural assessment in NHPs with stroke is feasible and could have translational relevance in subsequent human studies. Further studies will be necessary to replicate and expand on these preliminary findings.
Subjects/Keywords: Stroke
;
Non-Human Primate
;
Translational Research
;
KINARM
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CSE |
Export
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Manager
APA (6th Edition):
Olesovsky, S. (2016). Robotic Outcome Assessment in a Non-Human Primate Model of Middle Cerebral Artery Stroke
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/14459
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Olesovsky, Shelby. “Robotic Outcome Assessment in a Non-Human Primate Model of Middle Cerebral Artery Stroke
.” 2016. Thesis, Queens University. Accessed January 16, 2021.
http://hdl.handle.net/1974/14459.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Olesovsky, Shelby. “Robotic Outcome Assessment in a Non-Human Primate Model of Middle Cerebral Artery Stroke
.” 2016. Web. 16 Jan 2021.
Vancouver:
Olesovsky S. Robotic Outcome Assessment in a Non-Human Primate Model of Middle Cerebral Artery Stroke
. [Internet] [Thesis]. Queens University; 2016. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1974/14459.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Olesovsky S. Robotic Outcome Assessment in a Non-Human Primate Model of Middle Cerebral Artery Stroke
. [Thesis]. Queens University; 2016. Available from: http://hdl.handle.net/1974/14459
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Bristol
12.
Fletcher, Alisson W.
The social development of immature mountain gorillas (Gorilla gorilla beringei).
Degree: PhD, 1994, University of Bristol
URL: http://hdl.handle.net/1983/5e41bec3-a725-49cc-bbc8-84d49e4794d5
Subjects/Keywords: 590; Primate behaviour
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APA (6th Edition):
Fletcher, A. W. (1994). The social development of immature mountain gorillas (Gorilla gorilla beringei). (Doctoral Dissertation). University of Bristol. Retrieved from http://hdl.handle.net/1983/5e41bec3-a725-49cc-bbc8-84d49e4794d5
Chicago Manual of Style (16th Edition):
Fletcher, Alisson W. “The social development of immature mountain gorillas (Gorilla gorilla beringei).” 1994. Doctoral Dissertation, University of Bristol. Accessed January 16, 2021.
http://hdl.handle.net/1983/5e41bec3-a725-49cc-bbc8-84d49e4794d5.
MLA Handbook (7th Edition):
Fletcher, Alisson W. “The social development of immature mountain gorillas (Gorilla gorilla beringei).” 1994. Web. 16 Jan 2021.
Vancouver:
Fletcher AW. The social development of immature mountain gorillas (Gorilla gorilla beringei). [Internet] [Doctoral dissertation]. University of Bristol; 1994. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1983/5e41bec3-a725-49cc-bbc8-84d49e4794d5.
Council of Science Editors:
Fletcher AW. The social development of immature mountain gorillas (Gorilla gorilla beringei). [Doctoral Dissertation]. University of Bristol; 1994. Available from: http://hdl.handle.net/1983/5e41bec3-a725-49cc-bbc8-84d49e4794d5
University of Toronto
13.
Tennenhouse, Erica.
Unique Lemur Traits: Proximate and Ultimate Perspectives.
Degree: PhD, 2016, University of Toronto
URL: http://hdl.handle.net/1807/93577
► Members of the lemur clade are known to exhibit a number of traits that are unusual in the context of living primates. Here, I investigate…
(more)
▼ Members of the lemur clade are known to exhibit a number of traits that are unusual in the context of living primates. Here, I investigate the basis of three of these traits: sexual size monomorphism, female dominance over males, and rapid rates of growth and attainment of adult body mass. My research focuses on multiple lemur species from the current and historic colony residing at the Duke Lemur Center in Durham, NC. Using long-term morphological data on 18 lemur species, I determine that rapid growth and early attainment of adult body mass do not constrain the development of sexual size dimorphism in lemurs. Next, I conduct behavioural observations and hair hormone analysis on ring-tailed lemurs (Lemur catta), revealing that receiving aggression leads to chronic stress in males and females and that female dominance and high rates female of aggression in females are potentially mediated by sex steroid hormone concentrations. Finally, using growth records and hair hormone analysis in Coquerelâ s sifakas (Propithecus coquereli), I identify a negative relationship between chronic stress and relative body mass in early life, and demonstrate a potential carryover effect of low body mass in early life on relative body mass in adulthood. Uncovering the proximate and ultimate causes of these unique lemur traits can advance our understanding of the factors underlying trait variation in primates and other mammals.
2019-02-09 00:00:00
Advisors/Committee Members: Schillaci, Michael A, Anthropology.
Subjects/Keywords: Behaviour; Dominance; Evolution; Growth; Hormone; Primate; 0412
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APA (6th Edition):
Tennenhouse, E. (2016). Unique Lemur Traits: Proximate and Ultimate Perspectives. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/93577
Chicago Manual of Style (16th Edition):
Tennenhouse, Erica. “Unique Lemur Traits: Proximate and Ultimate Perspectives.” 2016. Doctoral Dissertation, University of Toronto. Accessed January 16, 2021.
http://hdl.handle.net/1807/93577.
MLA Handbook (7th Edition):
Tennenhouse, Erica. “Unique Lemur Traits: Proximate and Ultimate Perspectives.” 2016. Web. 16 Jan 2021.
Vancouver:
Tennenhouse E. Unique Lemur Traits: Proximate and Ultimate Perspectives. [Internet] [Doctoral dissertation]. University of Toronto; 2016. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1807/93577.
Council of Science Editors:
Tennenhouse E. Unique Lemur Traits: Proximate and Ultimate Perspectives. [Doctoral Dissertation]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/93577
California State University – Sacramento
14.
Reynolds, Serena M.
"Abnormal behavior" or "mental illness"?: investigating the continuity of profound social withdrawal exhibited by humans and chimpanzees.
Degree: MA, Anthropology, 2012, California State University – Sacramento
URL: http://hdl.handle.net/10211.9/1565
► This study tests the hypothesis that aspects of human mental illness also occur in chimpanzees. Because humans and chimpanzees are so close evolutionarily, with regards…
(more)
▼ This study tests the hypothesis that aspects of human mental illness also occur in chimpanzees. Because humans and chimpanzees are so close evolutionarily, with regards to genes and sociality, it was hypothesized that these species might also share a common range of illnesses. This study focused on behavioral indicators of profound social withdrawal because it is an easily observable and unambiguous sign of mental illness in humans. To test the research hypothesis, a five question retrospective survey was completed by caretakers and directors of zoos and sanctuaries. The survey asked respondents to provide behavioral reports of profound social isolation within four contexts, if it was exhibited by any of their chimpanzees. Responses were received for a total of 51 chimpanzees. Two of these chimpanzees were identified as exhibiting profound social isolation that was considered homologous to voluntary social isolation exhibited by humans afflicted with mental illness. The implications of these results, as well as the limitations and suggestions for future research are discussed.
Advisors/Committee Members: Sullivan, Roger J..
Subjects/Keywords: Primate behavior; Comparative psychology; Phylogeny of behavior
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APA (6th Edition):
Reynolds, S. M. (2012). "Abnormal behavior" or "mental illness"?: investigating the continuity of profound social withdrawal exhibited by humans and chimpanzees. (Masters Thesis). California State University – Sacramento. Retrieved from http://hdl.handle.net/10211.9/1565
Chicago Manual of Style (16th Edition):
Reynolds, Serena M. “"Abnormal behavior" or "mental illness"?: investigating the continuity of profound social withdrawal exhibited by humans and chimpanzees.” 2012. Masters Thesis, California State University – Sacramento. Accessed January 16, 2021.
http://hdl.handle.net/10211.9/1565.
MLA Handbook (7th Edition):
Reynolds, Serena M. “"Abnormal behavior" or "mental illness"?: investigating the continuity of profound social withdrawal exhibited by humans and chimpanzees.” 2012. Web. 16 Jan 2021.
Vancouver:
Reynolds SM. "Abnormal behavior" or "mental illness"?: investigating the continuity of profound social withdrawal exhibited by humans and chimpanzees. [Internet] [Masters thesis]. California State University – Sacramento; 2012. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10211.9/1565.
Council of Science Editors:
Reynolds SM. "Abnormal behavior" or "mental illness"?: investigating the continuity of profound social withdrawal exhibited by humans and chimpanzees. [Masters Thesis]. California State University – Sacramento; 2012. Available from: http://hdl.handle.net/10211.9/1565
University of Sydney
15.
Zeater, Natalie.
Integrative function in the marmoset lateral geniculate nucleus
.
Degree: 2016, University of Sydney
URL: http://hdl.handle.net/2123/15691
► The lateral geniculate nucleus (LGN) is the principal recipient of signals from the retina and is the main source of visual input to the cortex.…
(more)
▼ The lateral geniculate nucleus (LGN) is the principal recipient of signals from the retina and is the main source of visual input to the cortex. The information the LGN sends to the visual cortex is not a simple relay of retinal signals. It is also clearly affected by inputs to the LGN from a variety of sub-cortical nuclei. The common marmoset (Calithrix jacchus) is a New- World diurnal monkey, which is becoming increasingly popular as a model for the human visual system. Since, so far, the sources of sub-cortical inputs to the LGN of marmoset have not been clearly delineated, the sources of sub-cortical inputs to the marmoset LGN and some of the putative effects those inputs might exert on LGN signals are the principal focus of this thesis. Chapter 1 provides an overall introduction to the functional anatomy of the primate LGN and its connections. Chapter 2 constitutes an anatomical study examining the organisation of brainstem, tectal and pretectal inputs to the marmoset LGN and how it compares to the organisation of those inputs in other primates and several non-primate mammalian species. A retrograde tracer (Microruby) was injected into the LGN of an anaesthetised marmoset. The visuotopically organized nuclei such as superior colliculus, its ‘satellite’ parabigeminal nucleus and pretectal nucleus of the optic tract and were all found to send projections to the LGN. We were able to establish that the collicular projection to LGN is visuotopic. Overall, the organisation of sub-cortical projections to the marmoset LGN is very similar to the organisation of sub-cortical projections to LGN found in other primate species, but differs quite substantially from those in murid rodents or eutherian carnivores. Chapter 3 investigates the shared variability (noise correlations) between the LGN neurons. Using a 32-channel array, spike activity of many single cells was recorded simultaneously from the LGN of an anaesthetised marmoset. We have found that noise correlations between parvocellular cells were very low, noise correlations between pairs of magnocellular (M) cells was higher while noise correlations between pairs of koniocellular (K) cells were substantially and significantly higher. This indicates that the connectivity of P cells is ‘designed’ in a way to avoid noise correlations. It is suggested that this lack of substantial noise correlations between P cells subserves their functional role in high acuity vision. Furthermore, it was possible to measure noise correlations between K cells up to 800 μm apart. It is suggested that these noise correlations may result from the topographically diffuse organisation of sub-cortical inputs to the LGN. Chapter 4 investigates a subset of koniocellular neurons in the LGN, which show excitatory responses (generate action potentials) to the presentation of visual stimuli to either eye (binocular cells). While almost all P and M LGN neurons appear to receive excitatory supra-threshold input from one eye only, the binocular cells recorded from K layers exhibit similar receptive field…
Subjects/Keywords: lateral geniculate nucleus;
primate;
vision;
neuroscience
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zeater, N. (2016). Integrative function in the marmoset lateral geniculate nucleus
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/15691
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zeater, Natalie. “Integrative function in the marmoset lateral geniculate nucleus
.” 2016. Thesis, University of Sydney. Accessed January 16, 2021.
http://hdl.handle.net/2123/15691.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zeater, Natalie. “Integrative function in the marmoset lateral geniculate nucleus
.” 2016. Web. 16 Jan 2021.
Vancouver:
Zeater N. Integrative function in the marmoset lateral geniculate nucleus
. [Internet] [Thesis]. University of Sydney; 2016. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2123/15691.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zeater N. Integrative function in the marmoset lateral geniculate nucleus
. [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/15691
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New South Wales
16.
Stone, Olivia Mary Leigh.
The Biogeography and Palaeobiogeography of the Chacma Baboon (Papio ursinus).
Degree: Biological, Earth & Environmental Sciences, 2014, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/53384
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12079/SOURCE02?view=true
► Biogeographic knowledge of the chacma baboon (Papio ursinus) is generalised and imprecise. Published distributions are qualitative and actual population counts and location data are few…
(more)
▼ Biogeographic knowledge of the chacma baboon (Papio ursinus) is generalised and imprecise. Published distributions are qualitative and actual population counts and location data are few and spatially limited. This research attempts to provide quantitative data to allow repeatable biogeographic assessments of the chacma baboon. Where actual data counts are unknown and impractical to assess, this research provides estimates that, unlike the qualitative data of the past, can be easily updated, validated and remeasured with higher precision. These issues are first addressed by modelling the distribution of chacma baboon habitat and, by association, the potential distribution of the species prior to anthropogenic influence. This is the first quantitative detailed distribution estimate available at a continental scale. Next, anthropogenic influence is explored by assessing the human impact on areas predicted to be the most conducive to species survival. Findings suggest much of the land designated as central niche habitat (land most buffered from the environmental extremes experienced by the population) is impacted by human occupation. The majority of this habitat is within South Africa and the status of baboons in Lesotho appears to be unknown. A case study from the province of KwaZulu-Natal, South Africa, assesses the current population and distribution, finding the population dependent on protected areas and likely in decline. To better understand the species history, the central niche was then investigated through a glacial-interglacial cycle. This indicated a reciprocal relationship of expansion and contraction between the chacma clades. It also identified key areas with stable moderate environmental conditions that would have been central niche habitat regardless of the stage of the glacial-interglacial cycle. Finally, this research explored an association between this ancient habitat prediction and fossil hominins. Although potentially coincidental, it appears there may be a biogeographic bias to the fossil hominin locations. A model of potential hominin core habitat was developed to explore this. My research has provided essential baseline data and knowledge which was a necessary step towards accumulating quality data for future scientific, conservation or management efforts.
Advisors/Committee Members: Laffan, Shawn, Biological, Earth & Environmental Sciences, Faculty of Science, UNSW, Curnoe, Darren, Biological, Earth & Environmental Sciences, Faculty of Science, UNSW, Herries, Andy, School of Historical and European Studies, Faculty of Humanities and Social Sciences, La Trobe University, Melbourne, Australia.
Subjects/Keywords: Palaeobiogeography; Baboon; Biogeography; Primate; Africa; GIS
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APA (6th Edition):
Stone, O. M. L. (2014). The Biogeography and Palaeobiogeography of the Chacma Baboon (Papio ursinus). (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/53384 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12079/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Stone, Olivia Mary Leigh. “The Biogeography and Palaeobiogeography of the Chacma Baboon (Papio ursinus).” 2014. Doctoral Dissertation, University of New South Wales. Accessed January 16, 2021.
http://handle.unsw.edu.au/1959.4/53384 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12079/SOURCE02?view=true.
MLA Handbook (7th Edition):
Stone, Olivia Mary Leigh. “The Biogeography and Palaeobiogeography of the Chacma Baboon (Papio ursinus).” 2014. Web. 16 Jan 2021.
Vancouver:
Stone OML. The Biogeography and Palaeobiogeography of the Chacma Baboon (Papio ursinus). [Internet] [Doctoral dissertation]. University of New South Wales; 2014. [cited 2021 Jan 16].
Available from: http://handle.unsw.edu.au/1959.4/53384 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12079/SOURCE02?view=true.
Council of Science Editors:
Stone OML. The Biogeography and Palaeobiogeography of the Chacma Baboon (Papio ursinus). [Doctoral Dissertation]. University of New South Wales; 2014. Available from: http://handle.unsw.edu.au/1959.4/53384 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12079/SOURCE02?view=true
University of Bristol
17.
Fletcher, Alisson W.
The social development of immature mountain gorillas (Gorilla gorilla beringei).
Degree: PhD, 1994, University of Bristol
URL: https://research-information.bris.ac.uk/en/studentTheses/5e41bec3-a725-49cc-bbc8-84d49e4794d5
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294546
Subjects/Keywords: 590; Primate behaviour
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APA (6th Edition):
Fletcher, A. W. (1994). The social development of immature mountain gorillas (Gorilla gorilla beringei). (Doctoral Dissertation). University of Bristol. Retrieved from https://research-information.bris.ac.uk/en/studentTheses/5e41bec3-a725-49cc-bbc8-84d49e4794d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294546
Chicago Manual of Style (16th Edition):
Fletcher, Alisson W. “The social development of immature mountain gorillas (Gorilla gorilla beringei).” 1994. Doctoral Dissertation, University of Bristol. Accessed January 16, 2021.
https://research-information.bris.ac.uk/en/studentTheses/5e41bec3-a725-49cc-bbc8-84d49e4794d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294546.
MLA Handbook (7th Edition):
Fletcher, Alisson W. “The social development of immature mountain gorillas (Gorilla gorilla beringei).” 1994. Web. 16 Jan 2021.
Vancouver:
Fletcher AW. The social development of immature mountain gorillas (Gorilla gorilla beringei). [Internet] [Doctoral dissertation]. University of Bristol; 1994. [cited 2021 Jan 16].
Available from: https://research-information.bris.ac.uk/en/studentTheses/5e41bec3-a725-49cc-bbc8-84d49e4794d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294546.
Council of Science Editors:
Fletcher AW. The social development of immature mountain gorillas (Gorilla gorilla beringei). [Doctoral Dissertation]. University of Bristol; 1994. Available from: https://research-information.bris.ac.uk/en/studentTheses/5e41bec3-a725-49cc-bbc8-84d49e4794d5 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294546
Tulane University
18.
Lenz, Bryan B.
The effects of cattle ranching on a primate community in the central Amazon.
Degree: PhD, 2013, Tulane University
URL: https://digitallibrary.tulane.edu/islandora/object/tulane:23110
► According to the International Union for Conservation of Nature and Natural Resources (IUCN), 64% of primate species are declining in the wild and 49% face…
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▼ According to the International Union for Conservation of Nature and Natural Resources (IUCN), 64% of primate species are declining in the wild and 49% face a significant risk of extinction. This crisis is largely the result of human activity, including logging, ranching, and hunting. In this study I examine the impacts of the anthropogenic habitat disturbances associated with cattle ranching on a primate community. Research was conducted at the preeminent site for the study of rain forest fragmentation, the Biological Dynamics of Forest Fragments Project, Manaus, Brazil. I surveyed 8 line transects totaling 13 km that sampled: 1) secondary forest on abandoned cattle pasture,2) selectively logged primary forest, and 3) undisturbed primary forest. Specifically, I tested for edge effects, niche partitioning, and interhabitat differences in population density. Primate presence in edge habitats was negatively related to the amount of fruit consumed, a relationship that was also apparent in the densities of individual species. Four species were more abundant in edge habitats: Alouatta macconnelli (folivore-frugivore), Chiropotes chiropotes (seed predator), Saguinus midas (generalist), and Sapajus apella (generalist); one was less abundant: Ateles paniscus (frugivore); and the last showed no edge-related pattern: Pithecia chrysocephala (seed predator). Niche partitioning was evident in diet and macrohabitat use. In addition, in primary forest there was partitioning along several microhabitat variables. In secondary forest, however, microhabitat partitioning was absent, possibly due to habitat constraints or low encounter rates. Body size was positively related to use of vertical strata in both habitats, hence a combination of body size and competition may drive vertical niche partitioning. Primate characteristics were not related to their presence in selectively logged or undisturbed primary forest, though body size was inversely related to presence in secondary forest. Only the two generalists (Saguinus and Sapajus) heavily utilized secondary forest. The two largest species, Ateles (frugivore) and Alouatta (folivore-frugivore), showed an equal preference for all primary forest (logged and undisturbed) over secondary forest. Chiropotes (seed predator) also preferred undisturbed primary forest while Pithecia (seed predator) was relatively uniformly distributed.
Advisors/Committee Members: Jack, Katharine (Thesis advisor).
Subjects/Keywords: Primate behavior; Primate ecology; Conservation biology; School of Liberal Arts; Anthropology; Ph.D
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APA (6th Edition):
Lenz, B. B. (2013). The effects of cattle ranching on a primate community in the central Amazon. (Doctoral Dissertation). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:23110
Chicago Manual of Style (16th Edition):
Lenz, Bryan B. “The effects of cattle ranching on a primate community in the central Amazon.” 2013. Doctoral Dissertation, Tulane University. Accessed January 16, 2021.
https://digitallibrary.tulane.edu/islandora/object/tulane:23110.
MLA Handbook (7th Edition):
Lenz, Bryan B. “The effects of cattle ranching on a primate community in the central Amazon.” 2013. Web. 16 Jan 2021.
Vancouver:
Lenz BB. The effects of cattle ranching on a primate community in the central Amazon. [Internet] [Doctoral dissertation]. Tulane University; 2013. [cited 2021 Jan 16].
Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:23110.
Council of Science Editors:
Lenz BB. The effects of cattle ranching on a primate community in the central Amazon. [Doctoral Dissertation]. Tulane University; 2013. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:23110
19.
Cordeil, Stéphanie.
Etude de la différence de susceptibilité des lentivirus de primates aux interférons de type I : Study of the different susceptibility of primate lentiviruses to type I Interferons.
Degree: Docteur es, Sciences de la vie, 2012, Lyon, École normale supérieure
URL: http://www.theses.fr/2012ENSL0781
► Les IFN-I (interférons de type I), principalement IFN et , constituent un mécanisme de défense primordial de l’hôte contre les pathogènes. Pourtant, dans le cas…
(more)
▼ Les IFN-I (interférons de type I), principalement IFN et , constituent un mécanisme de défense primordial de l’hôte contre les pathogènes. Pourtant, dans le cas du VIH-1 (virus de l’immunodéficience humaine), la relation entre les IFN-I et la réplication virale apparaît plus complexe. En effet, si les IFN-I inhibent la réplication du VIH-1 ex vivo, un état d’hyperactivation permanent de la réponse IFN-I a été récemment associé à la progression vers le SIDA ainsi qu’à une forte virémie chez les patients infectés par le VIH-1. De même, la dérégulation de la réponse IFN-I est un critère déterminant dans l’issue pathogénique de certains modèles d’infection virale chez le singe. Si l’hypothèse du rôle pathogénique des IFN-I s’avère correcte, le VIH-1 pourrait avoir évolué afin de se répliquer même en présence d’une telle réponse, qui semble être au final, plus délétère pour l’hôte que pour le virus. L’objectif de ce travail a été d’évaluer la résistance du VIH-1 aux IFN. Dans ce contexte, le VIH-1 a été comparé au VIH-2 et au SIVmac (virus de l’immunodéficience simienne), virus phylogénétiquement proches mais peu ou pas pathogènes pour l’homme, lors de l’infection de plusieurs types cellulaires tels que des lymphocytes, des macrophages et des cellules dendritiques. En accord avec l’hypothèse initiale de travail, les expériences réalisées ont montré que le VIH-1 est capable de se répliquer dans les cellules primaires prétraitées avec des doses d’IFN comparables à celles mesurées in vivo, alors que la réplication des virus VIH-2/SIVmac est complètement bloquée, même à des concentrations très faibles d’IFN. Ce travail a permis de démontrer que le blocage induit par l’IFN s’exerce au niveau des phases précoces de l’infection et plus précisément à l’étape de la transcription inverse. En effet, les données obtenues suggèrent que l’IFN induit l’expression d’un effecteur cellulaire qui affecte différentiellement la stabilité des complexes viraux, ce qui se traduit par un défaut d’accumulation de l’ADN viral plus important pour le VIH-2 et le SIVmac, que pour le VIH-1. La différence de susceptibilité des lentivirus de primates aux IFN-I pourrait ainsi expliquer en partie, les différents niveaux de réplication de ces virus, associés à leurs degrés de pathogénicité in vivo.
Type I Interferons (IFN-α/β, herein IFNs) provide an important mechanism of defense against pathogens and regulate in a paracrine and autocrine manner both intrinsic and adaptive immune responses. In the case of HIV-1 however, the relationship between IFNs and viral replication appears more complex. Indeed, if IFNs have been described to interfere with HIV-1 at basically all phases of its life cycle ex vivo, an IFN-induced state is linked to AIDS progression and to high viral loads in HIV-1 infected individuals. Similarly, a deregulated and prolonged IFN production/state seems one of the main distinguishing features between pathogenic and non-pathogenic SIV infection in primate animal models, suggesting that a deregulated IFN-state may be more detrimental to…
Advisors/Committee Members: Cimarelli, Andrea (thesis director).
Subjects/Keywords: Lentivirus de primate; Interférons; Pathogenèse lentivirale; Macrophages; Primate lentiviruses; Interferons; Lentiviral pathogenesis; Macrophages
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APA ·
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APA (6th Edition):
Cordeil, S. (2012). Etude de la différence de susceptibilité des lentivirus de primates aux interférons de type I : Study of the different susceptibility of primate lentiviruses to type I Interferons. (Doctoral Dissertation). Lyon, École normale supérieure. Retrieved from http://www.theses.fr/2012ENSL0781
Chicago Manual of Style (16th Edition):
Cordeil, Stéphanie. “Etude de la différence de susceptibilité des lentivirus de primates aux interférons de type I : Study of the different susceptibility of primate lentiviruses to type I Interferons.” 2012. Doctoral Dissertation, Lyon, École normale supérieure. Accessed January 16, 2021.
http://www.theses.fr/2012ENSL0781.
MLA Handbook (7th Edition):
Cordeil, Stéphanie. “Etude de la différence de susceptibilité des lentivirus de primates aux interférons de type I : Study of the different susceptibility of primate lentiviruses to type I Interferons.” 2012. Web. 16 Jan 2021.
Vancouver:
Cordeil S. Etude de la différence de susceptibilité des lentivirus de primates aux interférons de type I : Study of the different susceptibility of primate lentiviruses to type I Interferons. [Internet] [Doctoral dissertation]. Lyon, École normale supérieure; 2012. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2012ENSL0781.
Council of Science Editors:
Cordeil S. Etude de la différence de susceptibilité des lentivirus de primates aux interférons de type I : Study of the different susceptibility of primate lentiviruses to type I Interferons. [Doctoral Dissertation]. Lyon, École normale supérieure; 2012. Available from: http://www.theses.fr/2012ENSL0781
20.
Martel, Anne-Caroline.
Stratum et perception du temps : analyse de la contribution des composants de la circuiterie striatale par une approche électrophysiologique chez le singe macaque : Striatum and time perception : an electrophysiological analysis of the relative contribution of distinct components of the striatal circuitry in the macaque monkey.
Degree: Docteur es, Neurosciences, 2019, Aix Marseille Université
URL: http://www.theses.fr/2019AIXM0661
► Comprendre comment le temps est représenté dans le cerveau est un enjeu majeur des recherches en neurosciences. Le striatum intervient dans le traitement des informations…
(more)
▼ Comprendre comment le temps est représenté dans le cerveau est un enjeu majeur des recherches en neurosciences. Le striatum intervient dans le traitement des informations temporelles dans la gamme de la seconde à la minute. Les objectifs de cette thèse ont été de mieux comprendre les mécanismes striataux qui sous-tendent la perception du temps chez le primate en s’intéressant à la distinction entre différentes modalités de traitement de l’information temporelle (contrôlée ou automatique), la contribution respective des interneurones et des neurones efférents du striatum, et l’influence de régions distinctes du striatum pouvant traiter différemment l’information temporelle. Chez deux macaques rhésus entraînés à estimer ou prédire la durée d’intervalles (1 à 2,3 s), nous avons analysé les changements d’activité neuronale en fonction de la durée des intervalles et du contexte temporel. L’objectif était d’identifier des corrélats du codage de l’information temporelle par deux populations de neurones, les neurones efférents et les Electrophysiologie, appelés respectivement "PANs" et "TANs". Nous avons constaté des changements d'activité des TANs reflétant des processus liés au codage temporel, sans effet de la durée de l'intervalle et avec une relative dépendance vis-à-vis du contexte temporel. Les patterns d'activation des PANs semblent eux transmettre des informations sur la durée des intervalles dans un contexte déterminé qui nécessite une estimation du temps écoulé ou la prédiction temporelle d'événements externes. L'ensemble de ces résultats fournit de nouvelles informations sur le traitement temporel au niveau de différents éléments de la circuiterie striatale.
A full understanding of how the brain creates a representation of time is a major challenge in neuroscience. The striatum is involved in the processing of temporal information for durations in the second-to-minute range. The general objectives of this thesis were to improve our understanding of striatal mechanisms underlying time perception in primates, with an emphasis on the distinction between differing modes of timing control (controlled or automatic), the respective contribution of local circuit neurons and output neurons in the striatum, and the influence of distinct striatal regions that may be differentially involved in timing processes. In two rhesus macaques trained to estimate or predict the duration of intervals (from 1 to 2.3 s), we have analyzed changes in striatal neuronal activity according to the interval duration and the timing context (estimation or prediction) within which these intervals are presented. This analysis aimed at identifying correlates of time encoding by two neuron types, namely output neurons and cholinergic interneurons, called "PANs" and "TANs", respectively. We found that changes in the activity of TANs may reflect processes related to but not specific to encoding of time, with no effect of interval duration and some dependency with the timing context. On the other hand, different activation patterns over PANs may…
Advisors/Committee Members: Apicella, Paul (thesis director).
Subjects/Keywords: Striatum; Timing; Primate; Electrophysiologie; Estimation; Prédiction; Striatum; Timing; Primate; Electrophysiology; Estimation; Prediction
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APA (6th Edition):
Martel, A. (2019). Stratum et perception du temps : analyse de la contribution des composants de la circuiterie striatale par une approche électrophysiologique chez le singe macaque : Striatum and time perception : an electrophysiological analysis of the relative contribution of distinct components of the striatal circuitry in the macaque monkey. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2019AIXM0661
Chicago Manual of Style (16th Edition):
Martel, Anne-Caroline. “Stratum et perception du temps : analyse de la contribution des composants de la circuiterie striatale par une approche électrophysiologique chez le singe macaque : Striatum and time perception : an electrophysiological analysis of the relative contribution of distinct components of the striatal circuitry in the macaque monkey.” 2019. Doctoral Dissertation, Aix Marseille Université. Accessed January 16, 2021.
http://www.theses.fr/2019AIXM0661.
MLA Handbook (7th Edition):
Martel, Anne-Caroline. “Stratum et perception du temps : analyse de la contribution des composants de la circuiterie striatale par une approche électrophysiologique chez le singe macaque : Striatum and time perception : an electrophysiological analysis of the relative contribution of distinct components of the striatal circuitry in the macaque monkey.” 2019. Web. 16 Jan 2021.
Vancouver:
Martel A. Stratum et perception du temps : analyse de la contribution des composants de la circuiterie striatale par une approche électrophysiologique chez le singe macaque : Striatum and time perception : an electrophysiological analysis of the relative contribution of distinct components of the striatal circuitry in the macaque monkey. [Internet] [Doctoral dissertation]. Aix Marseille Université 2019. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2019AIXM0661.
Council of Science Editors:
Martel A. Stratum et perception du temps : analyse de la contribution des composants de la circuiterie striatale par une approche électrophysiologique chez le singe macaque : Striatum and time perception : an electrophysiological analysis of the relative contribution of distinct components of the striatal circuitry in the macaque monkey. [Doctoral Dissertation]. Aix Marseille Université 2019. Available from: http://www.theses.fr/2019AIXM0661
21.
Wateau, Océane.
Mise au point et caractérisation fonctionnelle d'un modèle d'ischémie-reperfusion cérébrale chez le Macaque cynomolgus : Development and Development and functional characterization of a cerebral ischemia-reperfusion in a Cynomolgus macaque model.
Degree: Docteur es, Sciences de la vie et de la santé, 2020, Normandie
URL: http://www.theses.fr/2020NORMC401
► L’accident vasculaire cérébral est une pathologie dévastatrice et constitue l’une des premières causes de handicap acquis dans le monde. La thrombectomie mécanique par voie endovasculaire…
(more)
▼ L’accident vasculaire cérébral est une pathologie dévastatrice et constitue l’une des premières causes de handicap acquis dans le monde. La thrombectomie mécanique par voie endovasculaire est en train de changer drastiquement la prise en charge de l’AVC ischémique à la phase aiguë, en permettant une reperfusion rapide des tissus hypoperfusés et en réduisant la taille de l’infarct final. Bien que la reperfusion soit sans aucun doute bénéfique, elle peut également causer des lésions irréversibles des tissus, dites « d’ischémie-reperfusion ». Par conséquent, le développement de stratégies dites neuroprotectrices est essentiel pour contrer ces évènements délétères. Dans ce contexte, des modèles expérimentaux pertinents sont nécessaires pour tester de nouvelles thérapies et répondre à des questions importantes relatives à la progression de l’infarctus malgré une recanalisation réussie, la réversibilité des lésions ischémiques, la perturbation de la barrière hémato-encéphalique, les dommages de reperfusion, tout cela dans le but d’améliorer la récupération fonctionnelle post-infarctus. Durant ma thèse, nous avons développé un nouveau modèle non invasif d’ischémie-reperfusion cérébrale chez le primate non humain (Macaca fascicularis) reposant sur une approche endovasculaire peu invasive permettant une occlusion transitoire de l’artère cérébrale moyenne, puis sa reperfusion. La première partie de mes travaux a été consacrée à la mise au point de la méthode d’occlusion et du suivi neurofonctionnel des animaux grâce à l’utilisation de 3 outils que j’ai développés : une échelle d’évaluation neurologique, un test de dextérité manuelle et un test de réponse différée. La seconde partie de mes travaux a consisté à valider le modèle nouvellement développé et à le caractériser. Nous avons ainsi réussi à évaluer les dommages cérébraux per- et post-occlusion par des mesures innovantes d’imagerie (TEP-IRM multiparamétriques) ainsi que les déficits neurologiques des animaux sur le long terme. Ce nouveau modèle translationnel, proche de la réalité clinique, constitue un outil essentiel et innovant pour la recherche de cibles thérapeutiques visant à améliorer l’efficacité des traitements dans cette nouvelle ère de la thrombectomie.
Stroke is a devastating disease and is one of the first causes worldwide of acquired disability. Endovascular mechanical thrombectomy is dramatically changing the management of acute ischemic stroke, allowing a quick reperfusion of hypoperfused tissues and reducing the size of the final infarct. Although reperfusion is undoubtedly beneficial, it can also cause irreversible tissue damage. Therefore, the development of so-called neuroprotective strategies is essential to counteract these deleterious events. In this context, relevant experimental models are required for testing new therapies and addressing important questions about infarct progression despite successful recanalization, reversibility of ischemic lesions,…
Advisors/Committee Members: Agin, Véronique (thesis director), Canet-Soulas, Emmanuelle (thesis director).
Subjects/Keywords: Primate non-humain; Endovascular stroke model; Non-human primate; Reperfusion; Thrombectomy; PET-MRI Imaging
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Wateau, O. (2020). Mise au point et caractérisation fonctionnelle d'un modèle d'ischémie-reperfusion cérébrale chez le Macaque cynomolgus : Development and Development and functional characterization of a cerebral ischemia-reperfusion in a Cynomolgus macaque model. (Doctoral Dissertation). Normandie. Retrieved from http://www.theses.fr/2020NORMC401
Chicago Manual of Style (16th Edition):
Wateau, Océane. “Mise au point et caractérisation fonctionnelle d'un modèle d'ischémie-reperfusion cérébrale chez le Macaque cynomolgus : Development and Development and functional characterization of a cerebral ischemia-reperfusion in a Cynomolgus macaque model.” 2020. Doctoral Dissertation, Normandie. Accessed January 16, 2021.
http://www.theses.fr/2020NORMC401.
MLA Handbook (7th Edition):
Wateau, Océane. “Mise au point et caractérisation fonctionnelle d'un modèle d'ischémie-reperfusion cérébrale chez le Macaque cynomolgus : Development and Development and functional characterization of a cerebral ischemia-reperfusion in a Cynomolgus macaque model.” 2020. Web. 16 Jan 2021.
Vancouver:
Wateau O. Mise au point et caractérisation fonctionnelle d'un modèle d'ischémie-reperfusion cérébrale chez le Macaque cynomolgus : Development and Development and functional characterization of a cerebral ischemia-reperfusion in a Cynomolgus macaque model. [Internet] [Doctoral dissertation]. Normandie; 2020. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2020NORMC401.
Council of Science Editors:
Wateau O. Mise au point et caractérisation fonctionnelle d'un modèle d'ischémie-reperfusion cérébrale chez le Macaque cynomolgus : Development and Development and functional characterization of a cerebral ischemia-reperfusion in a Cynomolgus macaque model. [Doctoral Dissertation]. Normandie; 2020. Available from: http://www.theses.fr/2020NORMC401
Penn State University
22.
Sukhdeo, Simone Mallory.
SHAPE AND STRUCTURAL VARIATION IN THE DISTAL FEMUR OF CATARRHINE PRIMATES.
Degree: 2017, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/14707sms6065
► One of the primary goals of paleoanthropology is the reconstruction of past behavioral patterns from fossilized remains in order to resolve the evolutionary history of…
(more)
▼ One of the primary goals of paleoanthropology is the reconstruction of past behavioral patterns from fossilized remains in order to resolve the evolutionary history of living taxa. The hominin fossil record provides a rich resource of postcranial skeletal remains for the study of locomotor adaptations, under the assumed relationship between bone form and biomechanical function. Locomotor functional adaptation can be studied through the internal remodeling of trabecular structure to adapt to incurred loads and stresses as well as through external joint morphology that reflects joint posture and mobility. The purpose of this dissertation was to examine a sample of modern humans and their closest relatives, modern catarrhines, for the association between locomotor behavior and bone form, both internal and external, and to introduce fossil hominins into the analysis to address the evolution of bipedalism in the hominin record.
The analysis focused on the distal femur, an integral component of the knee joint, a joint which has received considerable attention in the study of bipedal locomotor adaptations in the fossil hominin record. The knee joint is one of the primary weight-bearing structures in the hind limb, but its complex morphology and function have posed some challenge to the quantitative analysis of knee joint functional morphology from the perspective of the distal femur. This project used a subsample of four catarrhine taxa, Homo, Pan, Pongo, and Papio, to investigate trabecular bone structural variation in the entire distal femoral epiphysis using a whole-joint method. The resultant mapping of trabecular bone volume fraction showed highly variable patterns within and between species. A sector analysis resolved the variation to a degree, and revealed a signal of bipedal locomotor bony response in the human distal femur in the form of high bone volume fraction in the distal, flattened regions of the condyles. The analysis also showed evidence of flexed limb postures in the non-human primates.
A larger sample of catarrhine primates was used to analyze the three-dimensional shape variation of the distal femur, including the articular surface topography and surrounding structures using geometric morphometrics. Locomotor differences in distal femoral shape provided clear discrimination between locomotor groups in the analysis, and the bipedal adaptations of the modern human distal femur occupied a unique position in shape space relative to the other extant taxa. The features that distinguished groups in shape space tended to reflect joint rotational ability and mediolateral distribution of loads across the knee, and the analysis revealed the significant influence of size, substrate preference, and phylogeny on distal femoral shape variation, in addition to locomotor behavior. The inclusion of fossil hominins into the analysis underscored the suite of features associated with bipedal locomotion in the distal femur that correspond to efficiency of locomotion on two legs. The fossil hominins demonstrated an…
Advisors/Committee Members: Timothy Michael Ryan, Dissertation Advisor/Co-Advisor, Timothy Michael Ryan, Committee Chair/Co-Chair, Nina G Jablonski, Committee Member, Philip Reno, Committee Member, Matthew Logan Reimherr, Outside Member.
Subjects/Keywords: Functional morphology; Human evolution; Primate evolution; Primate adaptations; Trabecular bone; Bone functional adaptation; Geometric morphometrics; Knee joint
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APA (6th Edition):
Sukhdeo, S. M. (2017). SHAPE AND STRUCTURAL VARIATION IN THE DISTAL FEMUR OF CATARRHINE PRIMATES. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/14707sms6065
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sukhdeo, Simone Mallory. “SHAPE AND STRUCTURAL VARIATION IN THE DISTAL FEMUR OF CATARRHINE PRIMATES.” 2017. Thesis, Penn State University. Accessed January 16, 2021.
https://submit-etda.libraries.psu.edu/catalog/14707sms6065.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sukhdeo, Simone Mallory. “SHAPE AND STRUCTURAL VARIATION IN THE DISTAL FEMUR OF CATARRHINE PRIMATES.” 2017. Web. 16 Jan 2021.
Vancouver:
Sukhdeo SM. SHAPE AND STRUCTURAL VARIATION IN THE DISTAL FEMUR OF CATARRHINE PRIMATES. [Internet] [Thesis]. Penn State University; 2017. [cited 2021 Jan 16].
Available from: https://submit-etda.libraries.psu.edu/catalog/14707sms6065.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sukhdeo SM. SHAPE AND STRUCTURAL VARIATION IN THE DISTAL FEMUR OF CATARRHINE PRIMATES. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/14707sms6065
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
23.
Bonté, Elodie.
Fonctions exécutives chez le babouin (Papio papio) : variabilités interindividuelles : Development of bioinformatics tools and methods for gene expression and regulation study : application to diseases.
Degree: Docteur es, Neurosciences, 2012, Aix Marseille Université
URL: http://www.theses.fr/2012AIXM5005
► Les fonctions exécutives (FE) sont définies comme des processus de contrôle permettant d'adapter les comportements dans des situations nouvelles. La littérature sur l'homme fait état…
(more)
▼ Les fonctions exécutives (FE) sont définies comme des processus de contrôle permettant d'adapter les comportements dans des situations nouvelles. La littérature sur l'homme fait état de fortes variabilités interindividuelles dans l'exécution de ces FE, notamment liées à l'âge des individus. Dans une approche comparative, nous avons cherché à savoir si le primate non humain exprimait de telles variabilités interindividuelles, dans quelle mesure, et pour quelle(s) fonctions(s). Nous avons proposé une série de tâches à un groupe de babouins Papio papio où des individus mâles et femelles d'âges différents, et de statuts sociaux différents cohabitent. Ces expériences ont bénéficié de l'environnement exceptionnel de la plateforme de Comportement et Cognition du Primate située sur la station de Primatologie CNRS de Rousset, où un groupe de babouins a accès ad libitum à dix systèmes de conditionnement opérant automatisés. Les tâches proposées impliquaient chacune une FE particulière, notamment les fonctions d'inhibition et de flexibilité cognitive. Les procédures utilisées, qui reposent sur un principe de conditionnement opérant, consistaient à présenter les tâches sur des écrans tactiles sur lesquels les babouins devaient donner leur réponse. Les expériences impliquant principalement l'inhibition ont montré que le babouin est capable de mettre en place un contrôle inhibiteur efficace. Cependant, les individus les plus âgés montrent des déficits dans leurs performances. Au contraire, lorsque la tâche d'inhibition a une forte composante motrice, les jeunes ont plus de difficultés à adapter leur mouvement.
Executive functions (EF), which are defined as control processes, serve the adaptation of the behaviour in new situations. The human literature reveals important inter-individual variabilities in the efficiency of EF, in particular when age is considered. In a comparative perspective, we investigated if similar individual differences also exist in nonhuman primates, and for which function(s). Several tasks were thus proposed to a group of baboons Papio papio, comprising individuals of both sexes and different ages and social status. These experiments were run in a unique research facility, the Primate Behaviour and Cognition platform (Primatology center, Rousset-sur-Arc), where the baboons had an ad libitum free access to ten automated operant conditioning test systems equipped with touch screens. Each task targeted a particular EF, including the functions of inhibition and cognitive flexibility. The baboons demonstrated an efficient inhibitory control in our tasks. Overall, older individuals showed deficits in inhibitory control when compared to the younger subjects. However, this pattern of results is inverted when motor rather than cognitive inhibition was required. The second set of experiments studied cognitive flexibility. That EF appears deficient in adults, in comparison to the younger individuals. Thus, as in humans, monkeys show significant individual differences in executive control. It is concluded that their…
Advisors/Committee Members: Fagot, Joël (thesis director), Boussaoud, Driss (thesis director).
Subjects/Keywords: Fonctions exécutives; Contrôle exécutif; Primate; Inhibition; Flexibilité cognitive; Âge; Executive functions; Executive control; Primate; Inhibition; Cognitive flexibility; Age
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APA (6th Edition):
Bonté, E. (2012). Fonctions exécutives chez le babouin (Papio papio) : variabilités interindividuelles : Development of bioinformatics tools and methods for gene expression and regulation study : application to diseases. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2012AIXM5005
Chicago Manual of Style (16th Edition):
Bonté, Elodie. “Fonctions exécutives chez le babouin (Papio papio) : variabilités interindividuelles : Development of bioinformatics tools and methods for gene expression and regulation study : application to diseases.” 2012. Doctoral Dissertation, Aix Marseille Université. Accessed January 16, 2021.
http://www.theses.fr/2012AIXM5005.
MLA Handbook (7th Edition):
Bonté, Elodie. “Fonctions exécutives chez le babouin (Papio papio) : variabilités interindividuelles : Development of bioinformatics tools and methods for gene expression and regulation study : application to diseases.” 2012. Web. 16 Jan 2021.
Vancouver:
Bonté E. Fonctions exécutives chez le babouin (Papio papio) : variabilités interindividuelles : Development of bioinformatics tools and methods for gene expression and regulation study : application to diseases. [Internet] [Doctoral dissertation]. Aix Marseille Université 2012. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2012AIXM5005.
Council of Science Editors:
Bonté E. Fonctions exécutives chez le babouin (Papio papio) : variabilités interindividuelles : Development of bioinformatics tools and methods for gene expression and regulation study : application to diseases. [Doctoral Dissertation]. Aix Marseille Université 2012. Available from: http://www.theses.fr/2012AIXM5005
24.
Etienne, Stephanie.
Etudes des processus cognitifs sous-tendant les stratégies utilisées lors de l'apprentissage d'une tâche de navigation spatiale : Study of cognitive processes underlying strategies used during spatial navigation task learning.
Degree: Docteur es, Sociétés, Politique, Santé publique. Sciences cognitives et Ergonomie. Sciences cognitives, 2013, Université de Bordeaux Segalen
URL: http://www.theses.fr/2013BOR22109
► Lors d'une tâche cognitive telle que la navigation spatiale dans un environnement connu, l'individu peut utiliser des stratégies différentes pour atteindre un but. Il peut…
(more)
▼ Lors d'une tâche cognitive telle que la navigation spatiale dans un environnement connu, l'individu peut utiliser des stratégies différentes pour atteindre un but. Il peut baser sa navigation sur une représentation mentale de l'espace (globale) ou utiliser une stratégie mettant en jeu des informations égocentriques ou associatives (indices physiques internes ou externes associatifs). Deux grands systèmes cérébraux sont impliqués dans l’apprentissage spatial : la formation hippocampique et les ganglions de la base. Ces deux systèmes utilisent des modalités différentes : l'hippocampe est plus spécifiquement lié à l'apprentissage par rapport à un référentiel externe (apprentissage allocentrique) alors que les ganglions de la base sont plutôt liés à l'apprentissage par rapport à un référentiel interne (apprentissage égocentrique). L’apprentissage parallèle entre les deux systèmes partage à la fois des aspects compétitifs et coopératifs. L’hippocampe étant peu atteint dans les stades précoces de la maladie de Parkinson, ceci fournit l'opportunité de développer des méthodes de rééducation basées sur le renforcement de l'apprentissage allocentrique. Dans cette optique, il faut tout d'abord bien comprendre le fonctionnement de ces mécanismes d'apprentissage dans le cerveau sain. Nous proposons ici un test qui vise à analyser les processus d'apprentissage des deux systèmes, pendant une tâche de navigation dans un labyrinthe. Nous voulons développer une variante de cette tâche qui permet de différencier le rôle respectif de l'hippocampe et des ganglions de la base dans ces processus d'apprentissage. L’objectif de cette étude est d'étudier les différentes modalités d'apprentissage spatial (allocentrique et egocentrique) afin de définir leurs cinétiques d'apprentissage et les interactions entre ces deux systèmes. Ces connaissances seront utilisées par la suite afin de pallier au déficit spécifique d'apprentissage égocentrique dans la maladie de parkinson. Ce projet a pour but de mettre au point une tâche de navigation spatiale permettant de mieux connaitre les modalités des différentes stratégies utilisées lors de la navigation spatiale chez le primate dans un premier temps. Ces données pourront éventuellement servir à l'ajustement d'un protocole pour des sujets humains sains ou souffrant de déficits cognitifs pouvant être compensés par l'adaptation stratégique.
In spatial navigation task, we can use several strategies to reach a goal. We can build a mental representation (global) of the environment, use egocentric (body-based) information or use available cues (internal or external). Two structures known to have roles in spatial information are the hippocampus and the striatum. It is now generally held that allocentric (external reference frame) learning is related to the hippocampus. On the other hand, the striatum is believed to be involved in egocentric representation. There is a parallel processing between those two system which sharing both competitive and cooperative interactions. The hippocampus is less damaged in the…
Advisors/Committee Members: Boraud, Thomas (thesis director).
Subjects/Keywords: Navigation spatiale; Stratégie; Mémoire; Cognition; Primate; Muscimol; Striatum; Labyrinthe; Spatial navigation; Strategy; Memory; Cognition; Primate; Muscimol; Striatum; Maze
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APA ·
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APA (6th Edition):
Etienne, S. (2013). Etudes des processus cognitifs sous-tendant les stratégies utilisées lors de l'apprentissage d'une tâche de navigation spatiale : Study of cognitive processes underlying strategies used during spatial navigation task learning. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2013BOR22109
Chicago Manual of Style (16th Edition):
Etienne, Stephanie. “Etudes des processus cognitifs sous-tendant les stratégies utilisées lors de l'apprentissage d'une tâche de navigation spatiale : Study of cognitive processes underlying strategies used during spatial navigation task learning.” 2013. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed January 16, 2021.
http://www.theses.fr/2013BOR22109.
MLA Handbook (7th Edition):
Etienne, Stephanie. “Etudes des processus cognitifs sous-tendant les stratégies utilisées lors de l'apprentissage d'une tâche de navigation spatiale : Study of cognitive processes underlying strategies used during spatial navigation task learning.” 2013. Web. 16 Jan 2021.
Vancouver:
Etienne S. Etudes des processus cognitifs sous-tendant les stratégies utilisées lors de l'apprentissage d'une tâche de navigation spatiale : Study of cognitive processes underlying strategies used during spatial navigation task learning. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2013. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2013BOR22109.
Council of Science Editors:
Etienne S. Etudes des processus cognitifs sous-tendant les stratégies utilisées lors de l'apprentissage d'une tâche de navigation spatiale : Study of cognitive processes underlying strategies used during spatial navigation task learning. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2013. Available from: http://www.theses.fr/2013BOR22109
Université de Grenoble
25.
Chahboun, Siham.
Comparaison des régions variables des anticorps de macaques (Macaca fascicularis) et de l' Homme et leurs utilisation pour la neutralisation des toxines botuliques A et B : Comparison of macaque (Macaca fascicularis)and human antibodies variable regions, and their use for botulinum toxins A and B neutralization.
Degree: Docteur es, Sciences de la vie, 2013, Université de Grenoble
URL: http://www.theses.fr/2013GRENV022
► Notre laboratoire a développé une stratégie d'isolement de fragments d'anticorps recombinants à partir de primates non humains (Macaca fascicularis) immunisés, en utilisant la technologie des…
(more)
▼ Notre laboratoire a développé une stratégie d'isolement de fragments d'anticorps recombinants à partir de primates non humains (Macaca fascicularis) immunisés, en utilisant la technologie des phages. Dans le cadre de cette thèse, une comparaison des séquences d'anticorps de macaques (Macaca Mulatta) et d'anticorps humains a toutefois montré que les anticorps des deux espèces présentent des différences qui rendent souhaitable une étape d'humanisation des anticorps de macaques. Cette stratégie a été utilisée dans le cadre du projet Européen AntiBotABE (www.antibotabe.com) et l'étape de criblage a été adaptée pour isoler des scFv neutralisant de façon croisée les toxines botuliques BoNT/B des sous-types B1 et B2, en utilisant séquentiellement l'holotoxine BoNT/B1 et un fragment recombinant représentant la région C-terminale de la chaîne lourde de BoNT/B2. Le meilleur scFv ciblant les régions C-terminales des chaînes lourdes de BoNT/B1 et BoNT/B2, B2-7, a montré une bonne capacité de neutralisation de BoNT/B1 et BoNT/B2 dans le test ex vivo de paralysie hémidiaphragmatique. Les régions charpentes du scFv B2-7 ont un pourcentage d'identité élevé (80 %) avec leurs homologues humains. Des scFv neutralisant BoNT/A1 en ciblant sa chaîne légère ont aussi été isolés, dont le scFv le plus efficace, 2H8, induit une diminution de 50% de l'activité endopeptidasique à une concentration correspondant à un rapport molaire 2H8/BoNT/A1 de 64000. Les régions charpentes de 2H8 ont également un pourcentage d'identité élevée (88%) avec leurs homologues humains. La versatilité de cette stratégie en fait un outil permettant l'isolement de nombreux autres fragments d'anticorps à visée thérapeutique.
Our laboratory has developed a strategy to isolate recombinant antibody fragments technology from immunized non human primates (Macaca fascicularis) by phage display. In the course of the present thesis, a comparison between macaque (Macaca mulatta) and human antibody sequences has demonstrated that antibodies of the two species are different. This difference makes the humanization of macaque antibodies desirable. The strategy was used in the framework of the European AntiBotABE project, and the screening was adapted to isolate antibody fragments cross neutralizing the B1 and B2 subtypes of botulinum B neurotoxin, by using sequentially the holotoxin BoNT/B1 and a recombinant fragment representing the C-terminal region of the heavy chain of BoNTB2. The best scFv targeting the C-terminal region of BoNT/B1 and BoNTB2 heavy chains, B2-7, demonstrated a high capacity to neutralize BoNT/B1 and BoNT/B2 in the ex vivo hemidiaphragmatic assay. A high identity (80%) between the framework regions of B2-7 and their human homologs was observed. ScFvs neutralizing BoNT/A1 by targeting its light chain were also isolated and among them, the scFv 2H8 induced a decrease of 50% in the endopeptidase activity at a concentration corresponding to a molar ratio of 2H8/BoNT/A1 of 64000. A high identity (88%) between the framework regions of 2H8 and their human homologs…
Advisors/Committee Members: Mathieu, Jacques (thesis director), Thullier, Philippe (thesis director).
Subjects/Keywords: Anticorps; Phage display; Humanisation; Neutralisation; Primate non humain; Toxines; Antibody; Phage display; Toxin; Humanization; Neutralization; Non human primate
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APA ·
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CSE |
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APA (6th Edition):
Chahboun, S. (2013). Comparaison des régions variables des anticorps de macaques (Macaca fascicularis) et de l' Homme et leurs utilisation pour la neutralisation des toxines botuliques A et B : Comparison of macaque (Macaca fascicularis)and human antibodies variable regions, and their use for botulinum toxins A and B neutralization. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2013GRENV022
Chicago Manual of Style (16th Edition):
Chahboun, Siham. “Comparaison des régions variables des anticorps de macaques (Macaca fascicularis) et de l' Homme et leurs utilisation pour la neutralisation des toxines botuliques A et B : Comparison of macaque (Macaca fascicularis)and human antibodies variable regions, and their use for botulinum toxins A and B neutralization.” 2013. Doctoral Dissertation, Université de Grenoble. Accessed January 16, 2021.
http://www.theses.fr/2013GRENV022.
MLA Handbook (7th Edition):
Chahboun, Siham. “Comparaison des régions variables des anticorps de macaques (Macaca fascicularis) et de l' Homme et leurs utilisation pour la neutralisation des toxines botuliques A et B : Comparison of macaque (Macaca fascicularis)and human antibodies variable regions, and their use for botulinum toxins A and B neutralization.” 2013. Web. 16 Jan 2021.
Vancouver:
Chahboun S. Comparaison des régions variables des anticorps de macaques (Macaca fascicularis) et de l' Homme et leurs utilisation pour la neutralisation des toxines botuliques A et B : Comparison of macaque (Macaca fascicularis)and human antibodies variable regions, and their use for botulinum toxins A and B neutralization. [Internet] [Doctoral dissertation]. Université de Grenoble; 2013. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2013GRENV022.
Council of Science Editors:
Chahboun S. Comparaison des régions variables des anticorps de macaques (Macaca fascicularis) et de l' Homme et leurs utilisation pour la neutralisation des toxines botuliques A et B : Comparison of macaque (Macaca fascicularis)and human antibodies variable regions, and their use for botulinum toxins A and B neutralization. [Doctoral Dissertation]. Université de Grenoble; 2013. Available from: http://www.theses.fr/2013GRENV022
26.
Sherdil, Ariana.
Stimulation, surveillance et algorithme de détection du noyau antérieur du thalamus dans le cadre d'un modèle d'épilepsie focale motrice chez le primate : STIMULATION THERAPY, MONITORING AND CLOSED-LOOP ALGORITHMS INTERFACING TO THE ANTERIOR NUCLEUS (AN) OF THE THALAMUS IN A FOCAL EPILEPSY MONKEY MODEL.
Degree: Docteur es, Neurosciences - Neurobiologie, 2017, Université Grenoble Alpes (ComUE)
URL: http://www.theses.fr/2017GREAV046
► Dans le cadre de l’étude du contrôle de l’épilepsie du lobe mésio temporal (MTLE), il a été montré que le noyau antérieur du thalamus (ANT)…
(more)
▼ Dans le cadre de l’étude du contrôle de l’épilepsie du lobe mésio temporal (MTLE), il a été montré que le noyau antérieur du thalamus (ANT) est impliqué dans les crises; son rôle exact n’a cependant pas encore été décrit. Cette implication ainsi que sa position stratégique au sein du circuit limbique de Papez en ont fait une cible de choix pour la stimulation cérébrale profonde (Deep Brain Stimulation, DBS). De nombreuses études ont ainsi été menées depuis une vingtaine d’années chez l’animal comme chez l’Homme, utilisant de nombreux paradigmes de stimulation, et de nombreuses conclusions, parfois contradictoires en ont découlé. Mais afin de pouvoir stimuler le ANT de manière adéquate pour obtenir un effet sur les crises, il faut comprendre de quelle façon il est impliqué dans la MTLE. Un modèle animal fiable et représentatif de la pathologie de l’Homme est nécessaire pour répondre à ces questions. Dans la première partie de ce travail nous avons caractérisé un modèle de MTLE à la demande chez le primate non-humain (NHP). Nous avons montré chez 5 NHPs qu’une injection de pénicilline (PNC) dans l’hippocampe (HPC) entraînait la survenue de crises typiques pendant 4 à 5 heures. La cinétique d’apparition et d’extinction des évènements ictaux ne varient pas entre les animaux et entre les différentes expériences ; de plus, la fréquence des crises présente un plateau stable, ce qui permettrait d’agir pendant cette période afin de tester de nouvelles drogues ou thérapies. Une sclérose hippocampique accompagnée de remaniements cellulaires a également pu être observée dans l’HPC injecté. Dans une seconde partie, nous avons utilisé ce modèle de MTLE afin d’identifier la nature de l’implication du ANT (simple relais passif ou nœud au sein du circuit épileptique primaire). Pour ce faire, nous avons évalué les effets de la neuromodulation chimique et électrique du ANT sur l’activité ictale de l’HPC. Nous avons pu observer un changement de l’épilepsie suite à la neuromodulation chimique du ANT, et également une variation de l’activité électrique de base de l’HPC à une certaine fréquence donnée de stimulation du ANT. Il s’est ensuite avéré que cette fréquence de stimulation entraînait une amélioration significative du nombre de crises et du temps total passé en crise. Enfin, nous avons essayé d’identifier au travers de l’analyse de cohérence entre les activités enregistrées simultanément dans le ANT et l’HPC des biomarqueurs électrophysiologiques prédictifs d’une bonne efficacité de la DBS. Cette démarche pourrait ainsi apporter des pistes afin de proposer une stimulation plus intelligente et mieux adaptée à chaque patient.
It has been shown that the anterior nucleus of the thalamus (ANT) is involved in the mésio temporal lobe epilepsy (mTLE); but its role has not been described yet. This implication, in addition to its strategic position within the Papez circuit makes it a prime target for the deep brain stimulation (DBS). Many studies have then been led for twenty years in humans and animals, using many stimulation paradigms,…
Advisors/Committee Members: Piallat, Brigitte (thesis director).
Subjects/Keywords: Epilepsie; Stimulation; Noyau Antérieur Thalamus; Model primate; Algorithme de stimulation; Epilepsy; Stimulation; Anterior Nucleus of the Thalamus; Primate; Stimulation algorithm; 610
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APA ·
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CSE |
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APA (6th Edition):
Sherdil, A. (2017). Stimulation, surveillance et algorithme de détection du noyau antérieur du thalamus dans le cadre d'un modèle d'épilepsie focale motrice chez le primate : STIMULATION THERAPY, MONITORING AND CLOSED-LOOP ALGORITHMS INTERFACING TO THE ANTERIOR NUCLEUS (AN) OF THE THALAMUS IN A FOCAL EPILEPSY MONKEY MODEL. (Doctoral Dissertation). Université Grenoble Alpes (ComUE). Retrieved from http://www.theses.fr/2017GREAV046
Chicago Manual of Style (16th Edition):
Sherdil, Ariana. “Stimulation, surveillance et algorithme de détection du noyau antérieur du thalamus dans le cadre d'un modèle d'épilepsie focale motrice chez le primate : STIMULATION THERAPY, MONITORING AND CLOSED-LOOP ALGORITHMS INTERFACING TO THE ANTERIOR NUCLEUS (AN) OF THE THALAMUS IN A FOCAL EPILEPSY MONKEY MODEL.” 2017. Doctoral Dissertation, Université Grenoble Alpes (ComUE). Accessed January 16, 2021.
http://www.theses.fr/2017GREAV046.
MLA Handbook (7th Edition):
Sherdil, Ariana. “Stimulation, surveillance et algorithme de détection du noyau antérieur du thalamus dans le cadre d'un modèle d'épilepsie focale motrice chez le primate : STIMULATION THERAPY, MONITORING AND CLOSED-LOOP ALGORITHMS INTERFACING TO THE ANTERIOR NUCLEUS (AN) OF THE THALAMUS IN A FOCAL EPILEPSY MONKEY MODEL.” 2017. Web. 16 Jan 2021.
Vancouver:
Sherdil A. Stimulation, surveillance et algorithme de détection du noyau antérieur du thalamus dans le cadre d'un modèle d'épilepsie focale motrice chez le primate : STIMULATION THERAPY, MONITORING AND CLOSED-LOOP ALGORITHMS INTERFACING TO THE ANTERIOR NUCLEUS (AN) OF THE THALAMUS IN A FOCAL EPILEPSY MONKEY MODEL. [Internet] [Doctoral dissertation]. Université Grenoble Alpes (ComUE); 2017. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2017GREAV046.
Council of Science Editors:
Sherdil A. Stimulation, surveillance et algorithme de détection du noyau antérieur du thalamus dans le cadre d'un modèle d'épilepsie focale motrice chez le primate : STIMULATION THERAPY, MONITORING AND CLOSED-LOOP ALGORITHMS INTERFACING TO THE ANTERIOR NUCLEUS (AN) OF THE THALAMUS IN A FOCAL EPILEPSY MONKEY MODEL. [Doctoral Dissertation]. Université Grenoble Alpes (ComUE); 2017. Available from: http://www.theses.fr/2017GREAV046
27.
Balbastre, Yaël.
Développement et validation d’outils pour l’analyse morphologique du cerveau de Macaque : Morphometry Analysis Tools for the Macaque Brain : Development and Validation.
Degree: Docteur es, Imagerie et physique médicale, 2016, Université Paris-Saclay (ComUE)
URL: http://www.theses.fr/2016SACLS333
► La compréhension des mécanismes impliqués dans les maladies neurodégénératives ou développementales ainsi que la mise en place de nouvelles approches thérapeutiques reposent sur l’utilisation de…
(more)
▼ La compréhension des mécanismes impliqués dans les maladies neurodégénératives ou développementales ainsi que la mise en place de nouvelles approches thérapeutiques reposent sur l’utilisation de modèles expérimentaux pertinents et de techniques d’imagerie adaptées. Dans ce contexte, l’IRM est un outil de choix pour l’exploration anatomique in vivo dans la mesure où elle permet d’effectuer un suivi longitudinal. Le succès translationnel des thérapies du laboratoire au patient repose sur une bonne caractérisation des modèles et une continuité des biomarqueurs utilisés. Or, si l'IRM est disponible en préclinique et en clinique, les outils d'analyse sont peu « génériques ». Au cours de cette thèse, en s'inspirant des travaux menés chez l'Homme, nous avons développé et validé des outils automatiques de segmentation des structures neuroanatomiques chez le Macaque. La méthode proposée repose sur la mise en registre avec l'IRM du sujet d'un atlas digital probabiliste suivi de l'optimisation d'un modèle statistique par mélanges de gaussiennes et champs aléatoires de Markov. Elle a été validée chez un ensemble de sujets sains adultes puis mise en application dans le contexte du développement néonatal normal du cerveau. Afin de poser les bases d'une évaluation permettant une comparaison des biomarqueurs IRM avec les biomarqueurs post mortem de référence, nous avons également mis au point une chaîne de traitement permettant la reconstruction 3D de volumes histologiques du cerveau de Macaque et l'avons appliqué à la caractérisation du contraste IRM au cours d'une greffe de cellules souches après lésion excitotoxique.
Understanding the mechanisms involved in neurodegenerative or developmental diseases and designing new therapeutic approaches are based on the use of relevant experimental models as well as appropriate imaging techniques. In this context, MRI is a prominent tool for in vivo investigation as it allows for longitudinal follow-up. Successful translation from bench to bedside calls for well-characterized models as well as transferable biomarkers. Yet, despite the existence of both clinical and preclinical scanners, analysis tools are hardly translational. In this work, inspired by standards developed in Humans, we've built and validated tools for the automated segmentation of neuroanatomical structures in the Macaque. This method is based on the registration of a digital probabilistic atlas followed by the fitting of a statistical model consisting of a gaussian mixture and Markov random fields. It was first validated in healthy adults and then applied to the study of neonatal brain development. Furthermore, to pave the way for comparisons with gold standard post mortem biomarkers, we developed a pipeline for the automated 3D reconstruction of histological volumes that we applied to the characterization of MRI contrast in a stem-cell graft following an excitotoxic lesion.
Advisors/Committee Members: Mangin, Jean-François (thesis director), Delzescaux, Thierry (thesis director).
Subjects/Keywords: Analyse d'Image; Cerveau; Primate Non-Humain; Sillons; Segmentation; Atlas; Image analysis; Brain; Non-Human Primate; Sulci; Segmentation; Atlas
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APA (6th Edition):
Balbastre, Y. (2016). Développement et validation d’outils pour l’analyse morphologique du cerveau de Macaque : Morphometry Analysis Tools for the Macaque Brain : Development and Validation. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2016SACLS333
Chicago Manual of Style (16th Edition):
Balbastre, Yaël. “Développement et validation d’outils pour l’analyse morphologique du cerveau de Macaque : Morphometry Analysis Tools for the Macaque Brain : Development and Validation.” 2016. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 16, 2021.
http://www.theses.fr/2016SACLS333.
MLA Handbook (7th Edition):
Balbastre, Yaël. “Développement et validation d’outils pour l’analyse morphologique du cerveau de Macaque : Morphometry Analysis Tools for the Macaque Brain : Development and Validation.” 2016. Web. 16 Jan 2021.
Vancouver:
Balbastre Y. Développement et validation d’outils pour l’analyse morphologique du cerveau de Macaque : Morphometry Analysis Tools for the Macaque Brain : Development and Validation. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2016. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2016SACLS333.
Council of Science Editors:
Balbastre Y. Développement et validation d’outils pour l’analyse morphologique du cerveau de Macaque : Morphometry Analysis Tools for the Macaque Brain : Development and Validation. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2016. Available from: http://www.theses.fr/2016SACLS333
28.
Lemaitre, Julien.
Heterogeneity of polymorphonuclear neutrophils in HIV-1 infection. Study of SIV-infected cynomolgus macaque model. : Hétérogénéité des polynucléaires neutrophiles dans l'infection par le VIH-1.Etude du modèle macaque cynomolgus infecté par le SIV.
Degree: Docteur es, Immunologie, 2019, Université Paris-Saclay (ComUE)
URL: http://www.theses.fr/2019SACLS267
► La persistance du VIH-1 est associée au maintien de l’inflammation chronique chez les patients infectés, malgré la mise en place de combinaison de traitements antirétroviraux.…
(more)
▼ La persistance du VIH-1 est associée au maintien de l’inflammation chronique chez les patients infectés, malgré la mise en place de combinaison de traitements antirétroviraux. L’inflammation chronique est associée à un risque augmenté de développer des comorbidités, non associées au SIDA. Les polynucléaires neutrophiles (PNN) sont des cellules myéloïdes qui ont été impliqués dans de multiples maladies inflammatoires chroniques. Néanmoins, leur rôle dans l’infection par le VIH-1 est moins bien connue. Afin de pallier ce manque de connaissances, nous avons évalué l’hétérogénéité des PNNs dans le modèle macaque cynomolgus infecté par le SIVmac251. L’analyse phénotypique par cytométrie de masse a révélé la circulation de PNNs immatures en phase chronique de l’infection. En caractérisant l’hétérogénéité des PNNs au cours de l’infection par le SIV, nous avons observé une augmentation des fréquences des neutrophiles immatures et activés dans le sang dès la primo-infection. En phase chronique, les PNNs immatures et activés étaient toujours significativement augmentés dans le sang et la moelle osseuse. Au cours de l’infection, les PNNs avaient une fonction immunostimulatrice envers la prolifération et la sécrétion cytokinique des lymphocytaire T. L’initiation d’un traitement antirétroviral précoce a permis de restaurer le phénotype des PNNs. Les PNNs sont des cellules à fort potentiel pro-inflammatoire abondantes qui devraient être ainsi considérés comme de nouveaux effecteurs de l’inflammation chronique associée au VIH-1.
Even under combinational antiretroviral treatments (cART), HIV-1 persistence is associated with chronic inflammation in infected patients, leading to an increased risk of non-AIDS-related comorbidities. Polymorphonuclear neutrophils (PMN), have been less studied in HIV infection whereas they were associated with chronic inflammation diseases. To evaluate PMN heterogeneity in SIVmac251 nonhuman primate infection model, we first performed multiparameter single-cell phenotyping by mass cytometry giving a global vision of the immune system. This analysis demonstrated circulation of immature PMN with impaired during chronic infection. Then, we characterized neutrophils heterogeneity in the course of SIV infection. In primary infection, there was an increased frequency of CD10- immature and CD62L-low primed PMNs in peripheral blood. In chronic phase, CD10- immature PMNs were significantly higher in bone marrow and blood, maintaining a primed profile. During SIV infection, PMNs demonstrated variable immunomodulatory function against T cells proliferation and cytokine production. Early cART allowed to restore PMN phenotype. In this study, we provide unprecedented insight into PMN heterogeneity in the course of SIV infection. Since PMN represent 40-70% of circulating leukocytes and primed PMN are more potent to release pro-inflammatory cytokines and to transmigrate, they should be considered as a new player in HIV-1 chronic inflammation.
Advisors/Committee Members: Lambotte, Olivier (thesis director), Beignon, Anne-Sophie (thesis director).
Subjects/Keywords: Immunité innée; Vih-1; Cellules myéloïdes; Inflammation chronique; Primate non humain; Siv; Innate immunity; Hiv; Neutrophils; Chronic inflammation; Nonhuman primate; Siv
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lemaitre, J. (2019). Heterogeneity of polymorphonuclear neutrophils in HIV-1 infection. Study of SIV-infected cynomolgus macaque model. : Hétérogénéité des polynucléaires neutrophiles dans l'infection par le VIH-1.Etude du modèle macaque cynomolgus infecté par le SIV. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2019SACLS267
Chicago Manual of Style (16th Edition):
Lemaitre, Julien. “Heterogeneity of polymorphonuclear neutrophils in HIV-1 infection. Study of SIV-infected cynomolgus macaque model. : Hétérogénéité des polynucléaires neutrophiles dans l'infection par le VIH-1.Etude du modèle macaque cynomolgus infecté par le SIV.” 2019. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 16, 2021.
http://www.theses.fr/2019SACLS267.
MLA Handbook (7th Edition):
Lemaitre, Julien. “Heterogeneity of polymorphonuclear neutrophils in HIV-1 infection. Study of SIV-infected cynomolgus macaque model. : Hétérogénéité des polynucléaires neutrophiles dans l'infection par le VIH-1.Etude du modèle macaque cynomolgus infecté par le SIV.” 2019. Web. 16 Jan 2021.
Vancouver:
Lemaitre J. Heterogeneity of polymorphonuclear neutrophils in HIV-1 infection. Study of SIV-infected cynomolgus macaque model. : Hétérogénéité des polynucléaires neutrophiles dans l'infection par le VIH-1.Etude du modèle macaque cynomolgus infecté par le SIV. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2019. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2019SACLS267.
Council of Science Editors:
Lemaitre J. Heterogeneity of polymorphonuclear neutrophils in HIV-1 infection. Study of SIV-infected cynomolgus macaque model. : Hétérogénéité des polynucléaires neutrophiles dans l'infection par le VIH-1.Etude du modèle macaque cynomolgus infecté par le SIV. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2019. Available from: http://www.theses.fr/2019SACLS267
29.
Blaize, Kevin.
Cartographier le traitement de l'information visuelle cérébrale grâce aux ultrasons fonctionnels : Mapping the cerebral visual information processing with functional ultrasounds.
Degree: Docteur es, Neurosciences, 2018, Sorbonne université
URL: http://www.theses.fr/2018SORUS114
► Le système visuel cérébral inclut le corps genouillé latéral, le colliculus supérieur et le cortex visuel. Ces structures ont été étudiées depuis les années 50…
(more)
▼ Le système visuel cérébral inclut le corps genouillé latéral, le colliculus supérieur et le cortex visuel. Ces structures ont été étudiées depuis les années 50 et cette étude a été possible par l’apparition de l’imagerie par résonnance magnétique fonctionnelle ainsi que par différentes techniques optiques. Pour évaluer la résolution spatiotemporelle de la technique d’imagerie ultrasonore, nous avons mesuré les réponses visuelles des structures cérébrales sur le rat anesthésié en étudiant leur dynamique respective soit sur un seul plan, soit par reconstruction tridimensionnelle. Après avoir validé cette approche technologique sur le petit animal, nous avons appliqué cette technique sur le cortex visuel du primate non-humain éveillé. Ainsi, nous avons pu reconstruire les cartes rétinotopiques du cortex visuel en surface mais aussi en profondeur. Nous avons mis en évidence, les bandes de dominance oculaire dans V1. En accord avec certaines données anatomiques, cette mesure fonctionnelle suggère la présence d’une dominance oculaire au-delà de la couche 4, dans les couches 3 et 5 de V1. En conclusion, ces travaux de thèse ont permis de montrer l’intérêt spécifique de l’imagerie fonctionnelle par ultrasons sur le rongeur et le primate non-humain, anesthésiés et vigiles. Cette nouvelle technique d'imagerie permet la visualisation fonctionnelle à haute résolution spatiotemporelle en profondeur des aires visuelles. Cette illustration sur le système visuel met en lumière l’intérêt prometteur du déploiement de cette technique pour l’exploration fonctionnelle de structures inaccessibles en imagerie optique de surface et en dessous de la résolution de l’IRMf.
In the brain, the visual system includes the Lateral Geniculate Nucleus, the Superior Colliculus and the visual cortex. These structures have been studied since the 50’s and these studies have relied on functional MRI but also on the development of functional surface microscopic imaging techniques. To examine the spatiotemporal resolution of the ultrafast ultrasound imaging technique, we measured visual responses in in the cerebral structures on anesthetized rats in one imaging plan or with a 3D reconstruction. After having validated our technology on rodents, we have applied the technique to awake non-human primate visual cortex. We reconstructed the retinotopic maps of visual cortex, at the surface and in depth. In addition, we could resolve the ocular dominance columns within V1, which represent a major functional structuration in the primary visual cortex. This functional observation suggests the presence of ocular dominance beyond layer 4 in layers 3 and 5 of V1. In conclusion, this thesis work has demonstrated that the functional ultrafast ultrasound imaging can measure activity in the visual system for both rats and non-human primates, anesthetized and awake. This new imaging technique can provide functional measures with a high spatiotemporal resolution in the deep tissue. This illustration on the visual system highlights the potential of the technique to measure…
Advisors/Committee Members: Picaud, Serge (thesis director).
Subjects/Keywords: Système visuel; Imagerie fonctionnelle; Ultrasons; Rongeur; Primate; Cartographie; Cortex visuel; Visual system; Functional imaging; Ultrasounds; Rodent; Primate; Mapping; Visual cortex; 573.8
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Blaize, K. (2018). Cartographier le traitement de l'information visuelle cérébrale grâce aux ultrasons fonctionnels : Mapping the cerebral visual information processing with functional ultrasounds. (Doctoral Dissertation). Sorbonne université. Retrieved from http://www.theses.fr/2018SORUS114
Chicago Manual of Style (16th Edition):
Blaize, Kevin. “Cartographier le traitement de l'information visuelle cérébrale grâce aux ultrasons fonctionnels : Mapping the cerebral visual information processing with functional ultrasounds.” 2018. Doctoral Dissertation, Sorbonne université. Accessed January 16, 2021.
http://www.theses.fr/2018SORUS114.
MLA Handbook (7th Edition):
Blaize, Kevin. “Cartographier le traitement de l'information visuelle cérébrale grâce aux ultrasons fonctionnels : Mapping the cerebral visual information processing with functional ultrasounds.” 2018. Web. 16 Jan 2021.
Vancouver:
Blaize K. Cartographier le traitement de l'information visuelle cérébrale grâce aux ultrasons fonctionnels : Mapping the cerebral visual information processing with functional ultrasounds. [Internet] [Doctoral dissertation]. Sorbonne université; 2018. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2018SORUS114.
Council of Science Editors:
Blaize K. Cartographier le traitement de l'information visuelle cérébrale grâce aux ultrasons fonctionnels : Mapping the cerebral visual information processing with functional ultrasounds. [Doctoral Dissertation]. Sorbonne université; 2018. Available from: http://www.theses.fr/2018SORUS114
30.
Dorieux, Olène.
Vieillissement cérébral chez un primate non humain, le Microcèbe : approches fonctionnelles et anatomiques : Cerebral aging in Microcebus murinus a non-human primate : functional and anatomical approaches.
Degree: Docteur es, Neurosciences, 2012, Université Paris Descartes – Paris V
URL: http://www.theses.fr/2012PA05T037
► De part le monde, nombre de personnes sont atteintes par pathologies cérébrales directement liées au vieillissement. Pour comprendre les mécanismes biologiques du vieillissement cérébral et…
(more)
▼ De part le monde, nombre de personnes sont atteintes par pathologies cérébrales directement liées au vieillissement. Pour comprendre les mécanismes biologiques du vieillissement cérébral et développer de nouvelles thérapies, l’utilisation de modèles animaux pertinents est un atout décisif. Le primate Microcèbe, est un modèle de vieillissement cérébral normal et pathologique. Il présente avec l’âge des altérations cérébrales anatomiques accompagnées de déficits cognitifs, similaires à celles observées chez l’Homme. Chez certains individus, ces altérations sont plus sévères, avec une atrophie de l’hippocampe et la présence de plaques amyloïdes, suggérant l’existence d’un vieillissement cérébral pathologique. L’exploration fonctionnelle du vieillissement cérébral du Microcèbe a été réalisée grâce à l’imagerie par Tomographie par Émission de Positons (TEP). Celle-ci a été complétée par des études anatomiques et histologiques du cerveau et un suivi comportemental. Une thérapie par un agoniste de l’Insuline-like Growth Factor 1 (PEG-IGF-1) a été évaluée. Chez les animaux âgés, outre la présence d’une atrophie cérébrale, le métabolisme glucidique était réduit dans le cerveau et les sous structures d’intérêt (cortex frontal, hippocampe, noyaux caudés et cervelet). Ces altérations cérébrales n’ont pas pu être associées à des déffcits cognitifs et ne peuvent être expliquées par des altérations anatomo-histologiques. Le traitement par PEG-IGF-1 n’a pas modifié la consommation cérébrale de glucose. Néanmoins, il s’est accompagné de changements dans les paramètres de la torpeur journalière présente chez ce primate, suggérant une modulation de la gestion des ressources énergétiques. En conclusion, la mesure du métabolisme glucidique cérébral par imagerie TEP constitue un marqueur fonctionnel du vieillissement cérébral chez le Microcèbe. Ce marqueur peut être utilisé pour explorer de nouveaux aspects du vieillissement cérébral et/ou l’apparition de pathologies. Il pourrait également permettre d’évaluer l’effet de thérapies sur le fonctionnement cérébral
Worldwide populations affected by age-related brain pathology are becoming increasingly numerous. Using relevant animal models is a critical to understand biological mechanisms of brain aging and evluate therapy. The Mouse lemur primate is an animal model of normal and pathological brain aging. Indeed, it develops age-associated brain abnormalities linked with cognitive deficits remaining human age-associated brain alterations. Moreover, some older individuals display more severe alterations, as in particular atrophy of the hippocampus and cerebral amyloid plaques, suggesting a pathological brain aging. Positron Emission Tomography (PET) was used to quantify cerebral glucose metabolism quantification in mouse lemurs. This study was completed with anatomical, histological, and behavioral studies. Additionally, an insulin-like growth agonist (PEG- IGF-1) therapy was evaluated in aged mouse lemurs. In older animals, besides a cerebral atrophy, a glucose metabolism reduction appeared…
Advisors/Committee Members: Perret, Martine (thesis director), Dhenain, Marc (thesis director).
Subjects/Keywords: Vieillissement; Cerveau; Primate; Imagerie fonctionnelle; Métabolisme; Microcebus murinus; Aging; Brain; Primate; Functional imaging; Metabolism; Mouse lemur
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Dorieux, O. (2012). Vieillissement cérébral chez un primate non humain, le Microcèbe : approches fonctionnelles et anatomiques : Cerebral aging in Microcebus murinus a non-human primate : functional and anatomical approaches. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2012PA05T037
Chicago Manual of Style (16th Edition):
Dorieux, Olène. “Vieillissement cérébral chez un primate non humain, le Microcèbe : approches fonctionnelles et anatomiques : Cerebral aging in Microcebus murinus a non-human primate : functional and anatomical approaches.” 2012. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed January 16, 2021.
http://www.theses.fr/2012PA05T037.
MLA Handbook (7th Edition):
Dorieux, Olène. “Vieillissement cérébral chez un primate non humain, le Microcèbe : approches fonctionnelles et anatomiques : Cerebral aging in Microcebus murinus a non-human primate : functional and anatomical approaches.” 2012. Web. 16 Jan 2021.
Vancouver:
Dorieux O. Vieillissement cérébral chez un primate non humain, le Microcèbe : approches fonctionnelles et anatomiques : Cerebral aging in Microcebus murinus a non-human primate : functional and anatomical approaches. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2012. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2012PA05T037.
Council of Science Editors:
Dorieux O. Vieillissement cérébral chez un primate non humain, le Microcèbe : approches fonctionnelles et anatomiques : Cerebral aging in Microcebus murinus a non-human primate : functional and anatomical approaches. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2012. Available from: http://www.theses.fr/2012PA05T037
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