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You searched for subject:( PKPD). Showing records 1 – 10 of 10 total matches.

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Universidade do Rio Grande do Norte

1. Silva Filho, Miguel Adelino da. Estudo físico-químico, farmacotoxicológico e modelagem pkpd para desenvolvimento de uma nova formulação micelar de anfotericina B .

Degree: 2017, Universidade do Rio Grande do Norte

 The increasing incidence of systemic fungal infections along with the growth of clinical isolates resistant to first line clinical treatment is a challenging epidemiological scenario… (more)

Subjects/Keywords: Anfotericina B; Tecnologia farmacêutica; Superagregados; Modelagem PKPD

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APA (6th Edition):

Silva Filho, M. A. d. (2017). Estudo físico-químico, farmacotoxicológico e modelagem pkpd para desenvolvimento de uma nova formulação micelar de anfotericina B . (Doctoral Dissertation). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/23941

Chicago Manual of Style (16th Edition):

Silva Filho, Miguel Adelino da. “Estudo físico-químico, farmacotoxicológico e modelagem pkpd para desenvolvimento de uma nova formulação micelar de anfotericina B .” 2017. Doctoral Dissertation, Universidade do Rio Grande do Norte. Accessed July 23, 2019. http://repositorio.ufrn.br/handle/123456789/23941.

MLA Handbook (7th Edition):

Silva Filho, Miguel Adelino da. “Estudo físico-químico, farmacotoxicológico e modelagem pkpd para desenvolvimento de uma nova formulação micelar de anfotericina B .” 2017. Web. 23 Jul 2019.

Vancouver:

Silva Filho MAd. Estudo físico-químico, farmacotoxicológico e modelagem pkpd para desenvolvimento de uma nova formulação micelar de anfotericina B . [Internet] [Doctoral dissertation]. Universidade do Rio Grande do Norte; 2017. [cited 2019 Jul 23]. Available from: http://repositorio.ufrn.br/handle/123456789/23941.

Council of Science Editors:

Silva Filho MAd. Estudo físico-químico, farmacotoxicológico e modelagem pkpd para desenvolvimento de uma nova formulação micelar de anfotericina B . [Doctoral Dissertation]. Universidade do Rio Grande do Norte; 2017. Available from: http://repositorio.ufrn.br/handle/123456789/23941


University of Southern California

2. Kay, Brittany P. Modeling anti-tumoral effects of drug-induced activation of the cell-extrinsic apoptotic pathway.

Degree: PhD, Biomedical Engineering, 2012, University of Southern California

 RshApo2L/TRAIL and Conatumumab bind to transmembrane death receptors and trigger the extrinsic cellular apoptotic pathway through a caspase-signaling cascade resulting in cell death. Tumor size… (more)

Subjects/Keywords: apoptosis; PKPD; PARA; extrinsic apoptotic pathway; cancer; modeling; caspase

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APA (6th Edition):

Kay, B. P. (2012). Modeling anti-tumoral effects of drug-induced activation of the cell-extrinsic apoptotic pathway. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/57385/rec/4122

Chicago Manual of Style (16th Edition):

Kay, Brittany P. “Modeling anti-tumoral effects of drug-induced activation of the cell-extrinsic apoptotic pathway.” 2012. Doctoral Dissertation, University of Southern California. Accessed July 23, 2019. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/57385/rec/4122.

MLA Handbook (7th Edition):

Kay, Brittany P. “Modeling anti-tumoral effects of drug-induced activation of the cell-extrinsic apoptotic pathway.” 2012. Web. 23 Jul 2019.

Vancouver:

Kay BP. Modeling anti-tumoral effects of drug-induced activation of the cell-extrinsic apoptotic pathway. [Internet] [Doctoral dissertation]. University of Southern California; 2012. [cited 2019 Jul 23]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/57385/rec/4122.

Council of Science Editors:

Kay BP. Modeling anti-tumoral effects of drug-induced activation of the cell-extrinsic apoptotic pathway. [Doctoral Dissertation]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/57385/rec/4122


Uppsala University

3. Lyly, Jonathan. PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa.

Degree: Pharmaceutical Biosciences, 2011, Uppsala University

  Resistant bacteria are becoming more and more of a problem but treatment with antibiotics in combination may overcome and prevent resistance development. The combination… (more)

Subjects/Keywords: meropenem; colistin; pseudomonas aeruginosa; models; pharmacometric models; pharmacokinetic models; PKPD; Pharmaceutical Sciences; Farmaceutiska vetenskaper

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APA (6th Edition):

Lyly, J. (2011). PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150283

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lyly, Jonathan. “PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa.” 2011. Thesis, Uppsala University. Accessed July 23, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150283.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lyly, Jonathan. “PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa.” 2011. Web. 23 Jul 2019.

Vancouver:

Lyly J. PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa. [Internet] [Thesis]. Uppsala University; 2011. [cited 2019 Jul 23]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150283.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lyly J. PKPD models for colistin and meropenem on a wild-type and a resistant strain of Pseudomonas aeruginosa. [Thesis]. Uppsala University; 2011. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150283

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Florida

4. Tatipalli, Manasa. Semi-Physiological Population Pk/Pd Model of Adc Neutropenia.

Degree: M.S.P., Pharmaceutical Sciences - Pharmaceutics, 2012, University of Florida

 Cancer is the second leading cause of mortalityin the United States, resulting in >500,000 American deaths annually. AntibodyDrug Conjugates (ADCs) are a class of therapeutics… (more)

Subjects/Keywords: Antibodies; Dosage; Drug design; Molecules; Monkeys; Neutropenia; Neutrophils; Parametric models; Pharmacokinetics; Toxicity; friberg  – neutropenia  – pkpd

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APA (6th Edition):

Tatipalli, M. (2012). Semi-Physiological Population Pk/Pd Model of Adc Neutropenia. (Masters Thesis). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0045141

Chicago Manual of Style (16th Edition):

Tatipalli, Manasa. “Semi-Physiological Population Pk/Pd Model of Adc Neutropenia.” 2012. Masters Thesis, University of Florida. Accessed July 23, 2019. http://ufdc.ufl.edu/UFE0045141.

MLA Handbook (7th Edition):

Tatipalli, Manasa. “Semi-Physiological Population Pk/Pd Model of Adc Neutropenia.” 2012. Web. 23 Jul 2019.

Vancouver:

Tatipalli M. Semi-Physiological Population Pk/Pd Model of Adc Neutropenia. [Internet] [Masters thesis]. University of Florida; 2012. [cited 2019 Jul 23]. Available from: http://ufdc.ufl.edu/UFE0045141.

Council of Science Editors:

Tatipalli M. Semi-Physiological Population Pk/Pd Model of Adc Neutropenia. [Masters Thesis]. University of Florida; 2012. Available from: http://ufdc.ufl.edu/UFE0045141

5. Steeg, Tamara Jessica van. The 'free drug hypothesis': fact or fiction?.

Degree: 2008, Department Pharmacology, Leiden / Amsterdam Center for Drug Research, (LACDR), Faculty of Science, Leiden University

 Protein binding can have major impact on a drug’s pharmacokinetics (PK) and pharmacodynamics (PD). At present the theoretical basis of the influence of (alterations in)… (more)

Subjects/Keywords: Beta-blockers; Pharmacodynamics; Pharmacokinetics; Plasma protein binding; PKPD modelling; Beta-blockers; Pharmacodynamics; Pharmacokinetics; Plasma protein binding; PKPD modelling

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APA (6th Edition):

Steeg, T. J. v. (2008). The 'free drug hypothesis': fact or fiction?. (Doctoral Dissertation). Department Pharmacology, Leiden / Amsterdam Center for Drug Research, (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/13283

Chicago Manual of Style (16th Edition):

Steeg, Tamara Jessica van. “The 'free drug hypothesis': fact or fiction?.” 2008. Doctoral Dissertation, Department Pharmacology, Leiden / Amsterdam Center for Drug Research, (LACDR), Faculty of Science, Leiden University. Accessed July 23, 2019. http://hdl.handle.net/1887/13283.

MLA Handbook (7th Edition):

Steeg, Tamara Jessica van. “The 'free drug hypothesis': fact or fiction?.” 2008. Web. 23 Jul 2019.

Vancouver:

Steeg TJv. The 'free drug hypothesis': fact or fiction?. [Internet] [Doctoral dissertation]. Department Pharmacology, Leiden / Amsterdam Center for Drug Research, (LACDR), Faculty of Science, Leiden University; 2008. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1887/13283.

Council of Science Editors:

Steeg TJv. The 'free drug hypothesis': fact or fiction?. [Doctoral Dissertation]. Department Pharmacology, Leiden / Amsterdam Center for Drug Research, (LACDR), Faculty of Science, Leiden University; 2008. Available from: http://hdl.handle.net/1887/13283


University of Otago

6. Owens, Katie Heather. Clinical pharmacology and toxicology of paracetamol in patient populations .

Degree: 2014, University of Otago

 Introduction: Paracetamol has been used as an analgesic and antipyretic drug in patient populations for decades. Recently, it has become available as an intravenous (IV)… (more)

Subjects/Keywords: clinical pharmacology; toxicology; pharmacy; paracetamol; acetaminophen; patient populations; clinical research; surgery; pharmacokinetics; pharmacodynamics; PKPD; modelling; Phoenix NLME; prothrombin time; INR; drug metabolism; Phoenix WinNonlin

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APA (6th Edition):

Owens, K. H. (2014). Clinical pharmacology and toxicology of paracetamol in patient populations . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/4675

Chicago Manual of Style (16th Edition):

Owens, Katie Heather. “Clinical pharmacology and toxicology of paracetamol in patient populations .” 2014. Doctoral Dissertation, University of Otago. Accessed July 23, 2019. http://hdl.handle.net/10523/4675.

MLA Handbook (7th Edition):

Owens, Katie Heather. “Clinical pharmacology and toxicology of paracetamol in patient populations .” 2014. Web. 23 Jul 2019.

Vancouver:

Owens KH. Clinical pharmacology and toxicology of paracetamol in patient populations . [Internet] [Doctoral dissertation]. University of Otago; 2014. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/10523/4675.

Council of Science Editors:

Owens KH. Clinical pharmacology and toxicology of paracetamol in patient populations . [Doctoral Dissertation]. University of Otago; 2014. Available from: http://hdl.handle.net/10523/4675


University of Florida

7. Samant, Snehal. An Integrative Approach to Personalizing Clopidogrel Antiplatelet Therapy.

Degree: PhD, Pharmaceutical Sciences - Pharmaceutics, 2016, University of Florida

Subjects/Keywords: antiplatelet; clopidogrel; cyp2c19; mechanism-based; model; pbpk; personalized; pharmacodynamics; pharmacokinetics; pkpd

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APA (6th Edition):

Samant, S. (2016). An Integrative Approach to Personalizing Clopidogrel Antiplatelet Therapy. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0050198

Chicago Manual of Style (16th Edition):

Samant, Snehal. “An Integrative Approach to Personalizing Clopidogrel Antiplatelet Therapy.” 2016. Doctoral Dissertation, University of Florida. Accessed July 23, 2019. http://ufdc.ufl.edu/UFE0050198.

MLA Handbook (7th Edition):

Samant, Snehal. “An Integrative Approach to Personalizing Clopidogrel Antiplatelet Therapy.” 2016. Web. 23 Jul 2019.

Vancouver:

Samant S. An Integrative Approach to Personalizing Clopidogrel Antiplatelet Therapy. [Internet] [Doctoral dissertation]. University of Florida; 2016. [cited 2019 Jul 23]. Available from: http://ufdc.ufl.edu/UFE0050198.

Council of Science Editors:

Samant S. An Integrative Approach to Personalizing Clopidogrel Antiplatelet Therapy. [Doctoral Dissertation]. University of Florida; 2016. Available from: http://ufdc.ufl.edu/UFE0050198


Leiden University

8. Witte, de, W.E.A. Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo.

Degree: 2017, Leiden University

 Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction. However, the time course of a drug effect is also… (more)

Subjects/Keywords: Binding kinetics; Dissociation rate constant; PKPD; Modeling; Rate-limiting ste; Discovery; Binding kinetics; Dissociation rate constant; PKPD; Modeling; Rate-limiting ste; Discovery

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Witte, de, W. E. A. (2017). Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/58472

Chicago Manual of Style (16th Edition):

Witte, de, W E A. “Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo.” 2017. Doctoral Dissertation, Leiden University. Accessed July 23, 2019. http://hdl.handle.net/1887/58472.

MLA Handbook (7th Edition):

Witte, de, W E A. “Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo.” 2017. Web. 23 Jul 2019.

Vancouver:

Witte, de WEA. Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo. [Internet] [Doctoral dissertation]. Leiden University; 2017. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1887/58472.

Council of Science Editors:

Witte, de WEA. Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo. [Doctoral Dissertation]. Leiden University; 2017. Available from: http://hdl.handle.net/1887/58472

9. Taneja, Amit. PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement.

Degree: 2013, Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Chronic pain is a significant health problem that greatly impacts the quality of life of individual patients and imparts high costs to society. Despite intense… (more)

Subjects/Keywords: PKPD; Relationships; Analgesic; Drug development; Target; Engagement; Prediction; Neuropathic pain; Chronic pain; Biomarkers; Translation; PKPD; Relationships; Analgesic; Drug development; Target; Engagement; Prediction; Neuropathic pain; Chronic pain; Biomarkers; Translation

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APA (6th Edition):

Taneja, A. (2013). PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement. (Doctoral Dissertation). Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/22300

Chicago Manual of Style (16th Edition):

Taneja, Amit. “PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement.” 2013. Doctoral Dissertation, Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed July 23, 2019. http://hdl.handle.net/1887/22300.

MLA Handbook (7th Edition):

Taneja, Amit. “PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement.” 2013. Web. 23 Jul 2019.

Vancouver:

Taneja A. PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement. [Internet] [Doctoral dissertation]. Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2019 Jul 23]. Available from: http://hdl.handle.net/1887/22300.

Council of Science Editors:

Taneja A. PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement. [Doctoral Dissertation]. Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/22300


University of Otago

10. Al-Sallami, Hesham. Optimising Patient Care by Individualising Drug Dosage .

Degree: University of Otago

 Drug therapy is an important component of the treatment and prevention of diseases. A drug is administered to achieve a treatment target so it is… (more)

Subjects/Keywords: Dose Individualisation; Pharmacometrics; PKPD; Covariates; Enoxaparin; Heparin; Clinical Pharmacology; Fat-free mass; Target-concentration intervention

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APA (6th Edition):

Al-Sallami, H. (n.d.). Optimising Patient Care by Individualising Drug Dosage . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/5787

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16th Edition):

Al-Sallami, Hesham. “Optimising Patient Care by Individualising Drug Dosage .” Doctoral Dissertation, University of Otago. Accessed July 23, 2019. http://hdl.handle.net/10523/5787.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7th Edition):

Al-Sallami, Hesham. “Optimising Patient Care by Individualising Drug Dosage .” Web. 23 Jul 2019.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Al-Sallami H. Optimising Patient Care by Individualising Drug Dosage . [Internet] [Doctoral dissertation]. University of Otago; [cited 2019 Jul 23]. Available from: http://hdl.handle.net/10523/5787.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Al-Sallami H. Optimising Patient Care by Individualising Drug Dosage . [Doctoral Dissertation]. University of Otago; Available from: http://hdl.handle.net/10523/5787

Note: this citation may be lacking information needed for this citation format:
No year of publication.

.