subject:( Lung function parameters)

Addis Ababa University

1. TIGIST, KENA. EFFECTS OF INDOOR AIR POLLUTION BY BIOMASS FUELS ON RESPIRATORY FUNCTIONS IN GONDAR, ETHIOPIA .

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/2987

► Poor households in Ethiopia depend heavily on wood, dung, and other biomass fuels for cooking. Inhalation of pollutants from these fuels may cause deleterious effects… (more)

▼ Poor households in Ethiopia depend heavily on wood, dung, and other biomass fuels for cooking. Inhalation of pollutants from these fuels may cause deleterious effects on health. The objective of this study was to investigate the effects of exposure to indoor air pollution from the use of biofuels on lung functions and respiratory symptoms in women. The study was conducted at Gondar town (kebele16) 750 kilometers from Addis Ababa between June and August 2010. A total of 285 women (200 biomass fuel users, 85 non users) between ages 18 and 59 years (mean age 29.7±9.14 for biomass users and 30.83±11.07 for controls) were selected by multistage cluster sampling technique. All selected subjects were non-smokers and used to cook 3-4 hr/ day regularly. Those who cook in open air without kitchen and smokers were excluded from the study. A closed end respiratory symptom questionnaire was administered by a trained laboratory technician at the house where the study participants were cooking. The questionnaire included history of smoking in the family, type of cooking fuel used, and duration of cooking and respiratory symptoms experienced, frequency of the signs and symptoms, past illness, etc . All Participants' height and weight were measured in light clothing and with their shoes removed. Height was measured to the nearest 0.1 cm using a standard meter while weight was measured to the nearest 100 g using Salter scales. Lung function tests (forced vital capacity (FVC), forced expiratory volume in the one second (FEV1) of each woman were measured by using a Spiro Pro spirometer and peak expiratory flow rates (PEFR) by Wright peak flow meter. Each subject was instructed to sit and practice with the instrument, to place the mouthpiece in the mouth keeping the nose closed, to make a maximal inspiratory effort, and to blow out with a maximal effort. The test was repeated five times after adequate rest, and results were obtained from the spirometer. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were derived from best spirogram recorded. Three peak expiratory flow rate (PEFR) readings were recorded using Wright peak flow meter and the maximum record was used. FEV1% (FVC/FEV1Χ 100) and individual predictive values based on age, sex, body weight, standing height were calculated by using predicted formula. The Carbon monoxide (CO) level used to assess indoor air pollution from biomass fuels was measured in each kitchen while cooking by using digital CO meter Metavico/09 as per instruction on the manual and the effect of this pollution on the women’s respiratory function was analyzed. The prevalence of wheeze (OR=8.11), phlegm (OR=17.1), bronchitis (OR=2.08) and asthma (OR=7.01) were significantly higher in the exposed groups relative to the no-exposure group. The mean measured value of ventilatory capacity FVC (2.20± 0.89 for biomass users and 2.62±0 .89 for controls, p=0.0004); FEV1 (1.67±0 .77 for biomass users and 2.24± 0.82 for controls, p=0.0002) and PEFR (181.45± 72.14 for biomass users and… Advisors/Committee Members: Prof. Yekoye Abebe (advisor).

Subjects/Keywords: Respiratory symptoms; Lung function parameters; Carbon monoxide; Indoor air pollution

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APA (6^th Edition):

TIGIST, K. (2012). EFFECTS OF INDOOR AIR POLLUTION BY BIOMASS FUELS ON RESPIRATORY FUNCTIONS IN GONDAR, ETHIOPIA . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/2987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

TIGIST, KENA. “EFFECTS OF INDOOR AIR POLLUTION BY BIOMASS FUELS ON RESPIRATORY FUNCTIONS IN GONDAR, ETHIOPIA .” 2012. Thesis, Addis Ababa University. Accessed March 03, 2021. http://etd.aau.edu.et/dspace/handle/123456789/2987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

TIGIST, KENA. “EFFECTS OF INDOOR AIR POLLUTION BY BIOMASS FUELS ON RESPIRATORY FUNCTIONS IN GONDAR, ETHIOPIA .” 2012. Web. 03 Mar 2021.

Vancouver:

TIGIST K. EFFECTS OF INDOOR AIR POLLUTION BY BIOMASS FUELS ON RESPIRATORY FUNCTIONS IN GONDAR, ETHIOPIA . [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Mar 03]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

TIGIST K. EFFECTS OF INDOOR AIR POLLUTION BY BIOMASS FUELS ON RESPIRATORY FUNCTIONS IN GONDAR, ETHIOPIA . [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

2. Tang, Wenbo. The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.

Degree: PhD, Nutrition, 2013, Cornell University

URL: http://hdl.handle.net/1813/34378

► Lung function is an important predictor of population morbidity and mortality. Decline in lung function is a natural part of aging, but accelerated loss in… (more)

▼ Lung function is an important predictor of population morbidity and mortality. Decline in lung function is a natural part of aging, but accelerated loss in lung function over time is a harbinger of chronic obstructive pulmonary disease (COPD), a leading cause of death globally. Smoking is widely recognized as the key risk factor for reduced lung function and COPD, although additional risk factors, such as genetics and nutrition, have been suggested to also play important roles in contributing to changes in lung function. The overall aim of this research was to investigate the role of, and interaction between, genetics, nutrition, and cigarette smoking in relation to the longitudinal change in lung function, as an indicator of COPD susceptibility. First, we explored the association between genetic variation within a network of antioxidant enzyme genes and the rate of change in lung function in a prospective cohort study of African and European American elderly adults; this study also investigated gene-bysmoking interaction. Evidence of association was identified for genetic variants in several candidate genes, among which were two novel genes (mGST3 and IDH3B) that interacted with smoking in both races/ethnicities. Second, to expand the scope of investigation to all common genetic variants iii throughout the entire human genome, we conducted a large-scale meta-analysis of genomewide association studies of longitudinal change in lung function in a consortium of 14 individual cohort studies of adults of European ancestry. We found evidence of association at two novel genetic loci (IL16/STARD5/TMC3 and ME3) in the meta-analysis and performed additional gene expression analyses to demonstrate that both loci harbor candidate genes with biologically plausible functional links to lung function. Finally, we explored the role of nutrition directly by investigating the relation between overall dietary patterns and longitudinal change in lung function in a prospective cohort of male adults, considering diet-by-smoking interaction. We identified two distinct dietary patterns by applying principal component analysis to food frequency questionnaire data, and found that a prudent diet rich in fruits, vegetables, fish, and poultry attenuated the accelerated decline in lung function in cigarette smokers, but had no association in non-smokers. iv Advisors/Committee Members: Cassano, Patricia Ann (chair), Wells, Martin Timothy (committee member), Clark, Andrew (committee member), Caudill, Marie A. (committee member).

Subjects/Keywords: Lung function; Genetics; Nutrition

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APA (6^th Edition):

Tang, W. (2013). The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/34378

Chicago Manual of Style (16^th Edition):

Tang, Wenbo. “The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.” 2013. Doctoral Dissertation, Cornell University. Accessed March 03, 2021. http://hdl.handle.net/1813/34378.

MLA Handbook (7^th Edition):

Tang, Wenbo. “The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.” 2013. Web. 03 Mar 2021.

Vancouver:

Tang W. The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. [Internet] [Doctoral dissertation]. Cornell University; 2013. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1813/34378.

Council of Science Editors:

Tang W. The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. [Doctoral Dissertation]. Cornell University; 2013. Available from: http://hdl.handle.net/1813/34378

University of Zambia

3. Siachingili, Lumba. Pulmonary function impairment in female workers exposed to environments with varied ambient air pollution in the central business area of Lusaka-Zambia .

Degree: 2015, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4390

► Previous studies have highlighted the role of ambient fine particulate matter as an important cause of both mortality and morbidity for many respiratory illnesses. When… (more)

▼ Previous studies have highlighted the role of ambient fine particulate matter as an important cause of both mortality and morbidity for many respiratory illnesses. When inhaled, PM2.5 causes to the airways and lungs obstructive, restrictive or both types of functional impairment through generation of highly reactive oxygen species. Physiological consequence is functional impairment manifested by reduced forced expiratory volume in one second (FEV1), functional vital capacity (FVC) and their ratio (i.e. FEV1/FVC). In Zambia, cleaners play an important role in maintaining health and hygiene. The nature of their job exposes them to varying degrees of PM2.5. The levels of PM2.5 in ambient Lusaka air are not known, and health-based limits for dust control in the work places are lacking. The study was undertaken in order to examine the associations between lung function status of female adult cleaners and fine particulate matter (PM2.5) concentrations in ambient Lusaka air. Materials and Methods The study included women between 18-50 years of age who had been working as street or office cleaners for 6 months or more. The cleaners were interviewed to get information on socio-demographic characteristics and other information using a structured interview schedule. The participants’ lung volumes, forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and their ratio (FEV1/FVC) were measured using a MRI spirobank G spirometer. On the day of the interview, PM2.5 in their work environment was sampled using a personal aerosol monitor (SIDEPAK AM510). The biomedical ethics committee of the University of Zambia, school of medicine, approved the research. Data were analysed using SPSS (version 20) for windows. Results Out of the 90 participants, 45 were street sweepers and 45 were office cleaners. More street sweepers had impaired lung function (FEV1/FVC) 15(75%) than office cleaners 5(25%). FEV1 was also significantly different among street sweepers 12(70.6%) and office cleaners 5(29.4%). PM2.5 measurements revealed significantly xv high levels of exposure among street sweepers. Participants with impaired lung function and those with reduced FEV1percent predicted were exposed to significantly high concentrations of PM2.5. Conclusion/Recommendation: Exposure to high PM2.5 concentration is associated with pulmonary function impairment and reduced FEV1 % predicted among cleaners. It is therefore, recommended that cleaners, be subjected to periodic health checks, in order to check for the development of cardiopulmonary symptoms and necessitate early intervention.

Subjects/Keywords: Lung-Diseases-Diagnosis; Pulmonary function tests

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APA (6^th Edition):

Siachingili, L. (2015). Pulmonary function impairment in female workers exposed to environments with varied ambient air pollution in the central business area of Lusaka-Zambia . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Siachingili, Lumba. “Pulmonary function impairment in female workers exposed to environments with varied ambient air pollution in the central business area of Lusaka-Zambia .” 2015. Thesis, University of Zambia. Accessed March 03, 2021. http://dspace.unza.zm:8080/xmlui/handle/123456789/4390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Siachingili, Lumba. “Pulmonary function impairment in female workers exposed to environments with varied ambient air pollution in the central business area of Lusaka-Zambia .” 2015. Web. 03 Mar 2021.

Vancouver:

Siachingili L. Pulmonary function impairment in female workers exposed to environments with varied ambient air pollution in the central business area of Lusaka-Zambia . [Internet] [Thesis]. University of Zambia; 2015. [cited 2021 Mar 03]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siachingili L. Pulmonary function impairment in female workers exposed to environments with varied ambient air pollution in the central business area of Lusaka-Zambia . [Thesis]. University of Zambia; 2015. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

4. Smart, Joanne Margaret. An investigation of body composition in people with and without Chronic Obstructive Pulmonary Disease (COPD).

Degree: MPhil, 2013, University of Newcastle

URL: http://hdl.handle.net/1959.13/1037978

►

Masters Research - Master of Philosophy (MPhil)

Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease, characterised by poorly reversible airflow limitation that is… (more)

▼

Masters Research - Master of Philosophy (MPhil)

Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease, characterised by poorly reversible airflow limitation that is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases, particularly cigarette smoke. The primary risk factor for COPD is cigarette smoking. Airway and systemic inflammation are features of COPD. The increasing prevalence and burden of COPD leads us to look at other factors that may influence the development and progression of COPD. Body composition, in particular low levels of fat free mass (FFM) is associated with worse survival and/or severity of COPD. Determinants of body composition include lifestyle factors such as dietary intake, physical activity patterns and smoking status, as well as age and gender. This thesis aimed to firstly examine the association between body composition, inflammation and lung function in healthy controls versus ex-smokers with or without COPD (Chapter 2). Secondly, it aimed to examine dietary intake, physical activity and inflammation as determinants of body composition in ex-smokers (Chapter 3). In Chapter 2, positive associations were observed between total and regional lean muscle mass and bone mineral content (BMC) and lung function in exsmokers. Conversely negative associations were observed between body fat mass and lung function in ex-smokers. An increase in body mass index (BMI) was associated with an increase in body fat, lean muscle mass and BMC in ex smokers without COPD. This was not seen in those with COPD, with the presence of disease appearing to modify the effects of weight gain. Lean muscle mass was also associated with better perceived quality of life and found to be negatively associated with systemic inflammation (CRP, IL-6, leptin). In Chapter 3, a positive association between lean muscle mass and dietary intake of nutrients found in fruit, vegetables, whole grains and fish was identified. Conversely, a negative association was observed between total body fat mass and dietary intake of nutrients found in fruit, vegetables, whole grains and fish. Dietary fat intake, physical activity and systemic inflammation were strong predictors of total body lean and fat mass in ex-smokers, but were not predictors of total body BMC. The protective effect of a high BMI in COPD does not appear to be due to an increase in fat mass but due to the presence of lean muscle mass. Reducing dietary fat intake, increasing physical activity and reducing systemic inflammation were identified as potential modifiable factors to improve and maintain lean muscle mass in ex-smokers. Assessment of diet and physical activity should be included in the management and care of those at risk of and those with COPD. Interventions targeting inflammation such as statins, omega-3 fatty and antioxidants may further improve outcomes in those ex-smokers with COPD.

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.

Subjects/Keywords: COPD; body composition; smoking; lung function

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smart, J. M. (2013). An investigation of body composition in people with and without Chronic Obstructive Pulmonary Disease (COPD). (Masters Thesis). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1037978

Chicago Manual of Style (16^th Edition):

Smart, Joanne Margaret. “An investigation of body composition in people with and without Chronic Obstructive Pulmonary Disease (COPD).” 2013. Masters Thesis, University of Newcastle. Accessed March 03, 2021. http://hdl.handle.net/1959.13/1037978.

MLA Handbook (7^th Edition):

Smart, Joanne Margaret. “An investigation of body composition in people with and without Chronic Obstructive Pulmonary Disease (COPD).” 2013. Web. 03 Mar 2021.

Vancouver:

Smart JM. An investigation of body composition in people with and without Chronic Obstructive Pulmonary Disease (COPD). [Internet] [Masters thesis]. University of Newcastle; 2013. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1959.13/1037978.

Council of Science Editors:

Smart JM. An investigation of body composition in people with and without Chronic Obstructive Pulmonary Disease (COPD). [Masters Thesis]. University of Newcastle; 2013. Available from: http://hdl.handle.net/1959.13/1037978

University of Alberta

5. Ye, Ming. Effect of Pesticides on Lung Function in the Canadian General Population.

Degree: PhD, Department of Public Health Sciences, 2015, University of Alberta

URL: https://era.library.ualberta.ca/files/cw95050623

► Although pesticide exposures have been associated with respiratory problems in humans, particularly in occupational settings, little is known about the effect of pesticides on lung… (more)

▼ Although pesticide exposures have been associated with respiratory problems in humans, particularly in occupational settings, little is known about the effect of pesticides on lung function in the general population. The objective of this thesis is to characterize the association between pesticide exposure and lung function among the Canadian general population using data from the Canadian Health Measure Survey (CHMS), a nation-wide cross-sectional health survey. In this thesis, the effect of organophosphate insecticides, pyrethroid insecticides, the organochlorine pesticide DDT [1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane], and the phenoxy herbicide 2,4-D (2,4-dichlorophenoxyacetic acid) on lung function was investigated using human biomonitoring data of pesticide exposures and spirometric measures of lung function among CHMS-Cycle 1 participants aged 6 to 79 years, a representative sample of the Canadian general population. In addition, dietary predictors of exposures to organophosphate (OP) and pyrethroid (PYR) insecticides were also investigated. Multiple linear regression was used to examine the association between pesticide exposures and lung function after controlling potential confounders, including demographic factors, socioeconomic factors, lifestyle factors and environmental factors. The main findings in this thesis were: 1) Urinary detections of the organophosphate and pyrethroid insecticide metabolites were highly prevalent among the CHMS participants, with dietary consumption of fruit and vegetables being a significant predictor of exposures to OP insecticides and dietary consumption of vegetables, and pulses/nuts for exposures to PYR insecticides; 2) Among adult participants aged 20-79 years, one unit increase in log transformed urinary concentration (nmol/g creatinine) of total dialkyl phosphates (DAP, metabolites of OP insecticides excreted in urine) was associated with a 32.6 mL reduction in forced vital capacity (FVC, p=0.014), a 32.6 mL reduction in forced expiratory volume in 1 second (FEV1, p=0.02), a 0.3% reduction in FEV1/FVC ratio (p=0.36) and a 53.1 mL/s reduction in forced expiratory flow between 25% and 75% of FVC (FEF25%-75%, p=0.081); 3) One unit increase in log transformed urinary concentration (nmol/g creatinine) of total pyrethorid insecticide metabolites (PYR) was associated with a 17.4 mL reduction in FEV1 (p=0.045) among participants aged 6-11 years, and a 37.1 mL reduction in FVC (p=0.05) among participants aged 12-19 years; 4) Among adult participants aged 20-79 years, individuals with detectable p,p’-DDT had significantly lower mean FVC (difference=310.7mL; p=0.003) and FEV1 (difference=231.8mL; p=0.015) than those without, and every 100 units (ng/g lipid) increase in the concentrations of p,p’-DDE [1,1-bis-(4-chlorophenyl)-2,2-dichloroethene], a metabolite of insecticide DDT, was associated with an 18.8 mL decrease in FVC (p-value=0.002) and an 11.8 mL decrease in FEV1 (p-value=0.013); and 5) No significant association was observed between urinary concentrations of herbicide…

Subjects/Keywords: pesticides; lung function; Canadian general population

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ye, M. (2015). Effect of Pesticides on Lung Function in the Canadian General Population. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cw95050623

Chicago Manual of Style (16^th Edition):

Ye, Ming. “Effect of Pesticides on Lung Function in the Canadian General Population.” 2015. Doctoral Dissertation, University of Alberta. Accessed March 03, 2021. https://era.library.ualberta.ca/files/cw95050623.

MLA Handbook (7^th Edition):

Ye, Ming. “Effect of Pesticides on Lung Function in the Canadian General Population.” 2015. Web. 03 Mar 2021.

Vancouver:

Ye M. Effect of Pesticides on Lung Function in the Canadian General Population. [Internet] [Doctoral dissertation]. University of Alberta; 2015. [cited 2021 Mar 03]. Available from: https://era.library.ualberta.ca/files/cw95050623.

Council of Science Editors:

Ye M. Effect of Pesticides on Lung Function in the Canadian General Population. [Doctoral Dissertation]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/cw95050623

University of Manchester

6. Hankinson, Jenny. The role of VEGF in lung function.

Degree: PhD, 2013, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-vegf-in-lung-function(763b07ca-4ba3-481e-894b-46abccd29250).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574292

► Background: Lung function is a highly heritable trait. So far there is limited knowledge of the genetic factors that influence lung function. Vascular endothelial growth… (more)

▼ Background: Lung function is a highly heritable trait. So far there is limited knowledge of the genetic factors that influence lung function. Vascular endothelial growth factor A (VEGF-A) is expressed in the lung at high levels and is known to play a role in angiogenesis and lung remodelling, both in utero and throughout life. A candidate gene study was carried out in order to investigate the role of variants within the VEGF-A gene in determining lung function in childhood and adult life.Methods: Using available longitudinal data previously collected for an unselected birth cohort (Manchester Asthma and Allergy Study-MAAS) the relationship between lung function and single-nucleotide polymorphisms (SNPs) in VEGF-A was assessed. Replication studies were performed in cross-sectional studies of adults from Manchester and children with asthma from Croatia, in whom FEV1/FVC ratio was measured using spirometry. The potential functional roles of two consistently associated SNPs were then further investigated. Finally, using the genome-wide data generated in the discovery cohort (MAAS) I assessed why associations between VEGF-A and lung function had not been reported in recent genome-wide association studies of lung function.Results: Two VEGF-A SNPs, rs10434 and rs3025028, were significantly associated with lung function at multiple ages in a discovery population (MAAS). Subjects with a GG genotype for either SNP had significantly diminished lung function compared to subjects with other genotypes. These findings were replicated in two additional populations (631 parents of children participating in MAAS and in 410 Croatian children with physician-diagnosed asthma aged 6-18 years). SNP rs10434 is located in the 3’UTR and based on its location I hypothesised that it may affect mRNA stability. No significant difference in the rate of VEGF-A mRNA degradation was found between GG and the AA homozygotes. SNP rs3025028 is an intronic SNP in a close proximity to the splice site involved in alternative splicing which generates two different isoforms of VEGF-A; I therefore tested the hypothesis that a change of base at this position could affect the splicing mechanism and cause a change in the ratio of the isoforms. Western blot analysis was used to demonstrate a difference in the ratio of the splice variants VEGF-A165b and total VEGF-A165 (relative to a reference sample) between genotype groups. The VEGF-A165b/panVEGF-A165 ratio was significantly higher at birth (cord plasma), in school-age children and in adults amongst CC compared to GG homozygotes at rs3025038 (p<0.03). Finally, the genome-wide data for the discovery cohort showed that the region containing VEGF-A was not well targeted by either genotyped or imputed SNPs in genome-wide arrays. Conclusion: Evidence was provided to demonstrate that variants within the VEGF-A gene are significantly associated with lung function in both children and adults. Furthermore, data was presented to support a functional role for one of the SNPs (rs3025028). I investigated why associations…

Subjects/Keywords: 616.24; VEGF; lung function; genetics; asthma

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APA (6^th Edition):

Hankinson, J. (2013). The role of VEGF in lung function. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-vegf-in-lung-function(763b07ca-4ba3-481e-894b-46abccd29250).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574292

Chicago Manual of Style (16^th Edition):

Hankinson, Jenny. “The role of VEGF in lung function.” 2013. Doctoral Dissertation, University of Manchester. Accessed March 03, 2021. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-vegf-in-lung-function(763b07ca-4ba3-481e-894b-46abccd29250).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574292.

MLA Handbook (7^th Edition):

Hankinson, Jenny. “The role of VEGF in lung function.” 2013. Web. 03 Mar 2021.

Vancouver:

Hankinson J. The role of VEGF in lung function. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Mar 03]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-vegf-in-lung-function(763b07ca-4ba3-481e-894b-46abccd29250).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574292.

Council of Science Editors:

Hankinson J. The role of VEGF in lung function. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-vegf-in-lung-function(763b07ca-4ba3-481e-894b-46abccd29250).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574292

University of Toronto

7. Rozenberg, Dmitry. Skeletal Muscle Dysfunction in Lung Transplant Patients.

Degree: PhD, 2017, University of Toronto

URL: http://hdl.handle.net/1807/80753

► Lung transplantation improves health-related quality of life (HRQL), daily function and survival for individuals with advanced lung disease. However, lung transplantation is now offered to… (more)

▼ Lung transplantation improves health-related quality of life (HRQL), daily function and survival for individuals with advanced lung disease. However, lung transplantation is now offered to older and more complex patients who are at a higher risk of skeletal muscle dysfunction; the implications of which remain uncertain. The overall objective was to assess how elements of muscle dysfunction (mass, strength and function) are associated with pre- and post-transplant physical function, HRQL, and clinical outcomes. We hypothesized that pre-transplant skeletal muscle dysfunction would be associated with impairments in pre-transplant HRQL, activities of daily-living (ADL), six-minute walk distance (6MWD), and worse post-transplant functional recovery with increased pre- and post-transplant mortality. Three studies targeting the pre- and post-transplant periods were undertaken. In study 1, a novel method of muscle mass quantification using computed tomography (CT) was retrospectively evaluated in 527 lung transplant candidates. CT muscle cross-sectional area in transplant candidates was 10% lower than age and sex-matched controls and independently associated with 6MWD, strength training volumes and post-transplant hospital length of stay (LOS), but no association was observed with pre- or post-transplant mortality. In study 2, muscle mass assessed with bio-electrical impedance, quadriceps strength, and function (Short Physical Performance Battery, SPPB) were prospectively evaluated in 50 lung transplant candidates. Quadriceps strength and SPPB were associated with pre-transplant HRQL, ADL, and 6MWD. Number of muscle deficits (mass, strength and/or function) was directly correlated with post-transplant hospital LOS, but not with delisting/mortality or post-transplant 6MWD. In study 3, the impact of pre-transplant skeletal muscle mass and function on post-transplant functional independence, HRQL, and 6MWD was evaluated in a select group of lung transplant recipients with prolonged mechanical ventilation (â Ľ 7 days). Age and intensive care unit (ICU) LOS were the only determinants of early post-transplant functional recovery, highlighting the importance of ICU-acquired morbidity. In summary, these studies demonstrate that skeletal muscle function is an important marker of pre-transplant daily function and predicts post-transplant hospital LOS, but is not a significant predictor of post-transplant function or mortality. Future studies should examine whether targeted rehabilitation strategies in the pre-transplant period may improve daily function and early post-transplant outcomes. Advisors/Committee Members: Singer, Lianne G, Mathur, Sunita, Medical Science.

Subjects/Keywords: Function; Lung; Muscle; Strength; Transplant; 0564

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APA (6^th Edition):

Rozenberg, D. (2017). Skeletal Muscle Dysfunction in Lung Transplant Patients. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/80753

Chicago Manual of Style (16^th Edition):

Rozenberg, Dmitry. “Skeletal Muscle Dysfunction in Lung Transplant Patients.” 2017. Doctoral Dissertation, University of Toronto. Accessed March 03, 2021. http://hdl.handle.net/1807/80753.

MLA Handbook (7^th Edition):

Rozenberg, Dmitry. “Skeletal Muscle Dysfunction in Lung Transplant Patients.” 2017. Web. 03 Mar 2021.

Vancouver:

Rozenberg D. Skeletal Muscle Dysfunction in Lung Transplant Patients. [Internet] [Doctoral dissertation]. University of Toronto; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1807/80753.

Council of Science Editors:

Rozenberg D. Skeletal Muscle Dysfunction in Lung Transplant Patients. [Doctoral Dissertation]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/80753

University of Melbourne

8. LODGE, CAROLINE. A longitudinal study of atopy, asthma and lung function from birth to 18 years in a high risk birth cohort.

Degree: 2012, University of Melbourne

URL: http://hdl.handle.net/11343/38274

► Background: The global burden of allergic disease, including asthma, eczema and allergic rhinoconjunctivitis is still increasing. Of these, asthma is the most important in terms… (more)

▼ Background: The global burden of allergic disease, including asthma, eczema and allergic rhinoconjunctivitis is still increasing. Of these, asthma is the most important in terms of morbidity, mortality and financial cost. Asthma is a global problem, estimated to affect 300 million people worldwide. Childhood asthma is the most common chronic disease of children in many westernized countries including Australia. We currently have no effective strategies to prevent development or persistence of asthma. A range of strategies have been trialled, including avoiding environmental triggers (dust mites, animal dander), modification of mothers’ and infants’ diets and randomized controlled trials of anti-inflammatory medications in children at high risk. To date, the results have been disappointing with very modest, if any, impact found. The lack of preventive strategies appears to be related to a poor understanding of asthma aetiology. There are many areas of controversy regarding the early life risk factors for the development of childhood asthma. Asthma is believed to result from a complex interaction between genetic, environmental and biological factors. Of these, the only consistent major risk factors to emerge to date are a family history of atopy or asthma, an individual history of atopy, early childhood eczema, environmental tobacco smoke and viral infections in early childhood. Asthma is known to be a heterogeneous disease in childhood, so that poor classification of asthma groups, or phenotypes, may be part of the reason for the lack of results within and inconsistent findings between studies. There is a critical need for studies which can provide a solid basis for accurate classification of asthma phenotypes as well as investigating plausible risk factors for the development and persistence of asthma. To address questions concerning the classification of asthma phenotypes and the natural history of asthma and allergic disease, along with genetic and environmental factors which may influence aetiology and progression, it is important to use the evidence provided by longitudinal studies. In longitudinal studies, especially birth cohorts with frequent ascertainment of potential aetiological exposures and allergic disease outcomes, it is possible to determine the temporal relationship between exposures and outcomes. This thesis addressed some of the issues in asthma and allergic disease research using data from a longitudinal birth cohort study. The Melbourne Atopy Cohort Study comprises 620 children who were selected before birth for familial allergic disease. These children were very closely followed in the first 2 years of life with 18 telephone interviews. They had yearly follow-ups between ages 3 and 7 and again at ages 12 and 18. Additionally they had clinic testing including cord blood, skin prick testing, and…

Subjects/Keywords: asthma; lung function; birth cohort; wheeze phenotypes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

LODGE, C. (2012). A longitudinal study of atopy, asthma and lung function from birth to 18 years in a high risk birth cohort. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38274

Chicago Manual of Style (16^th Edition):

LODGE, CAROLINE. “A longitudinal study of atopy, asthma and lung function from birth to 18 years in a high risk birth cohort.” 2012. Doctoral Dissertation, University of Melbourne. Accessed March 03, 2021. http://hdl.handle.net/11343/38274.

MLA Handbook (7^th Edition):

LODGE, CAROLINE. “A longitudinal study of atopy, asthma and lung function from birth to 18 years in a high risk birth cohort.” 2012. Web. 03 Mar 2021.

Vancouver:

LODGE C. A longitudinal study of atopy, asthma and lung function from birth to 18 years in a high risk birth cohort. [Internet] [Doctoral dissertation]. University of Melbourne; 2012. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11343/38274.

Council of Science Editors:

LODGE C. A longitudinal study of atopy, asthma and lung function from birth to 18 years in a high risk birth cohort. [Doctoral Dissertation]. University of Melbourne; 2012. Available from: http://hdl.handle.net/11343/38274

University of Southern California

9. Urman, Robert. Ambient air pollution and lung function in children.

Degree: PhD, Epidemiology, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/592394/rec/642

► The effect of air pollution on human health has long been a concern. The aim of this dissertation is to explore the negative impact of… (more)

▼ The effect of air pollution on human health has long been a concern. The aim of this dissertation is to explore the negative impact of probable causal pollutants or pollutant mixtures on respiratory health, with the focus mainly on the impacts of local or near‐roadway air pollution and that of elemental composition of particulate matter (PM) on lung function in children and adolescence. In urbanized locations, such as the Southern California communities that constitute the Children’s Health Study (CHS) and from which the population at focus in this dissertation is derived, motorized vehicles contribute a significantly large amount of the air pollution at both the local and regional scales. Prior studies have reported adverse effects of either regional or near‐roadway air pollution on lung function, but little has been done of the joint effects of these exposures. In the first study, analyses were conducted to assess the joint effects of these exposures on childhood lung function in the CHS. Results indicate that near‐roadway and regional air pollution have independent adverse effects on childhood lung function. However, specific components of the near‐roadway pollution mixture responsible for these effects have not been established. A major limitation for health studies is the lack of exposure models that estimate these components observed in epidemiological studies over fine spatial scale of tens to hundreds of meters. In the second study, exposure models were developed for fine‐scale variation in biologically relevant elemental carbon (EC). Models that included traffic measures provided useful estimates for EC₀.₂ and EC₂.₅ on a spatial scale appropriate for health studies of near-roadway pollution in selected Southern California communities. Moreover, numerous studies have reported adverse effects of PM on lung function in children, but there has been little investigation of the chronic effects of PM composition. Transition metals are biologically plausible agents contributing to these effects. Aerosol size and water-solubility may be important determinants of metal toxicity. In the third study, associations between lung development and concentrations of PM and transition metals (copper [Cu], iron [Fe], nickel [Ni], vanadium [V], and zinc [Zn]), in three size fractions [quasi-ultrafine ( Advisors/Committee Members: McConnell, Rob (Committee Chair), Gauderman, William James (Committee Member), Gilliland, Frank D. (Committee Member), Fruin, Scott (Committee Member), Wilson, John P. (Committee Member).

Subjects/Keywords: air pollution; traffic; lung function; children

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APA (6^th Edition):

Urman, R. (2015). Ambient air pollution and lung function in children. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/592394/rec/642

Chicago Manual of Style (16^th Edition):

Urman, Robert. “Ambient air pollution and lung function in children.” 2015. Doctoral Dissertation, University of Southern California. Accessed March 03, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/592394/rec/642.

MLA Handbook (7^th Edition):

Urman, Robert. “Ambient air pollution and lung function in children.” 2015. Web. 03 Mar 2021.

Vancouver:

Urman R. Ambient air pollution and lung function in children. [Internet] [Doctoral dissertation]. University of Southern California; 2015. [cited 2021 Mar 03]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/592394/rec/642.

Council of Science Editors:

Urman R. Ambient air pollution and lung function in children. [Doctoral Dissertation]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/592394/rec/642

University of Leicester

10. Gharbawi, Nidhal T. S. Lung function in children of different origins.

Degree: PhD, 2020, University of Leicester

URL: https://doi.org/10.25392/leicester.data.12656216.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.811555

► Background: Differences in lung function between people of varying ethnic origins are recognised, but the underlying physiological reasons have not been widely explored. Aims: The… (more)

▼ Background: Differences in lung function between people of varying ethnic origins are recognised, but the underlying physiological reasons have not been widely explored. Aims: The overall aim was to explore the physiological basis of differences in spirometry between white and South Asian children. Methods: We measured spirometry and maximum inspiratory pressures (MIP and MEP) in 307 children aged five to eleven years in primary schools. Spirometry included FEV1 and FVC. A subgroup of 37 children attended the laboratory for plethysmography and attempted measurements of distensibility of the respiratory system, made by measuring pressure and volume after brief interruptions of tidal breathing. Lung volumes were available from an additional 122 healthy children aged 7 to 16 years. Lung volume measurements were expressed as Z-scores based on predicted values for white children. Results: The mean(SD) FEV1 Z-scores for white and South Asian children were 0.17(1.01)and-0.55(0.97) respectively(p<0.001). Corresponding FVC Z-scores were 0.36(1.02) and-0.67(0.94), (p<0.001). We did not find significant ethnic differences in MIP or MEP. Adjusted mean(SD) MIP(kPa) was 7.51(1.99) for white and 7.02(1.91) for South Asians (p=0.14). Equivalent values for MEP(kPa) were 6.29(1.58) and 6.46(1.53), (p=0.48). Mean(SD) Z-scores for Total Lung Capacity were larger in white than south Asian children:(0.29(0.09) and -0.59(0.82) respectively, p<0.001). Mean(SD) Z-scores for Residual Volume were also larger in white children: (0.04(0.76) and -0.28(0.89) respectively, p=0.039). The measurements of distensibility yielded potentially useful data in 16/37 (43%) of children. Conclusions: Absolute lung volumes were lower in south Asian than white children. We did not find significant differences in respiratory muscle strength between two ethnic groups that would account for differences in spirometry. The distensibility of the respiratory system can be measured in almost half of children. Further work may show whether ethnic differences in distensibility exist, which could explain differences in spirometry.

Subjects/Keywords: lung function; children; spirometry; South Asia

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APA (6^th Edition):

Gharbawi, N. T. S. (2020). Lung function in children of different origins. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.12656216.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.811555

Chicago Manual of Style (16^th Edition):

Gharbawi, Nidhal T S. “Lung function in children of different origins.” 2020. Doctoral Dissertation, University of Leicester. Accessed March 03, 2021. https://doi.org/10.25392/leicester.data.12656216.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.811555.

MLA Handbook (7^th Edition):

Gharbawi, Nidhal T S. “Lung function in children of different origins.” 2020. Web. 03 Mar 2021.

Vancouver:

Gharbawi NTS. Lung function in children of different origins. [Internet] [Doctoral dissertation]. University of Leicester; 2020. [cited 2021 Mar 03]. Available from: https://doi.org/10.25392/leicester.data.12656216.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.811555.

Council of Science Editors:

Gharbawi NTS. Lung function in children of different origins. [Doctoral Dissertation]. University of Leicester; 2020. Available from: https://doi.org/10.25392/leicester.data.12656216.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.811555

University of Adelaide

11. Newbury, Wendy Lynne. Exploring the currency of spirometric predictive equations from the viewpoint of the lung age concept.

Degree: 2013, University of Adelaide

URL: http://hdl.handle.net/2440/83639

► Spirometry is used to diagnose respiratory disease, to monitor disease progression and response to treatment, and in epidemiological surveys. As a large burden of disease… (more)

▼ Spirometry is used to diagnose respiratory disease, to monitor disease progression and response to treatment, and in epidemiological surveys. As a large burden of disease is caused by cigarette smoking, spirometry has been incorporated in smoking cessation counselling in an attempt to improve quit rates. The concept of lung age (LA) was developed in 1985 in an effort to make spirometry results more easily understood by the lay person. Research results using LA to aid quitting remain inconclusive. This thesis investigates the need to update LA equations, as predictive equations based on old data may not be relevant for today’s populations, and contemporary equations may result in a stronger message for smokers. New LA equations were firstly developed using contemporary Australian data and four further LA equations were derived from previously published FEV₁ predictive equations. A series of comparisons of LA equations in contemporary Australian datasets followed. The first project compared the original Morris LA equations with newly developed Australian LA equations in an independent workplace dataset (males only). The second project compared four extra LA equations derived from previously published FEV₁ equations from Europe, the United Kingdom, America and Australia with the Morris and the new Australian equations. An independent dataset of randomly-selected males and females was used to compare these equations with the Morris LA equations and contemporary Australian LA equations. Lastly, a different type of LA equation expressed as delta lung age (ΔLA), the difference between chronological age and lung age, based on the ratio of Forced Expiratory Volume in one second/Forced Vital Capacity (FEV₁/FVC), was compared with three other LA equations based on FEV₁ alone. This project used three independent datasets (urban, rural and a workplace) for added strength. All LA equations confirmed poorer lung function in smokers than in never smokers in all 3 independent datasets. LA estimates were approximately 20 years lower using the original Morris equations when compared with the newest LA equations. The differences seen between estimated LA using all six equations were consistent in each analysis. The ΔLA equation gave extreme LA estimates in both the community-based datasets compared with the LA equations based on FEV₁ alone. These results show that the Morris LA equations need to be updated. However, there appears to be no advantage in using the ΔLA equation. The differences between the older and the newer LA equations are most likely a result of cohort and period effects. This is also the case in the predictive equations themselves. Continuously updating predictive equations using recently acquired data will result in LA equations that are more relevant to contemporary populations. Advisors/Committee Members: Crockett, Alan Joseph (advisor), Ruffin, Richard Ernest (advisor), School of Population Health (school).

Subjects/Keywords: spirometry; lung age; predictive equations; smoking cessation; COPD; lung function

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Newbury, W. L. (2013). Exploring the currency of spirometric predictive equations from the viewpoint of the lung age concept. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/83639

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Newbury, Wendy Lynne. “Exploring the currency of spirometric predictive equations from the viewpoint of the lung age concept.” 2013. Thesis, University of Adelaide. Accessed March 03, 2021. http://hdl.handle.net/2440/83639.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Newbury, Wendy Lynne. “Exploring the currency of spirometric predictive equations from the viewpoint of the lung age concept.” 2013. Web. 03 Mar 2021.

Vancouver:

Newbury WL. Exploring the currency of spirometric predictive equations from the viewpoint of the lung age concept. [Internet] [Thesis]. University of Adelaide; 2013. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2440/83639.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Newbury WL. Exploring the currency of spirometric predictive equations from the viewpoint of the lung age concept. [Thesis]. University of Adelaide; 2013. Available from: http://hdl.handle.net/2440/83639

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

12. Bui, Dinh Son. Risk factors for and outcomes of lung function deficits throughout the lifespan.

Degree: 2019, University of Melbourne

URL: http://hdl.handle.net/11343/225032

► Good lung function is essential for general health and longevity. The lungs are responsible for providing oxygen to meet the metabolic demands of the body… (more)

Subjects/Keywords: lung function; lung health; risk factor; COPD; epidemiology; biostatistics; respiratory; allergy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bui, D. S. (2019). Risk factors for and outcomes of lung function deficits throughout the lifespan. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/225032

Chicago Manual of Style (16^th Edition):

Bui, Dinh Son. “Risk factors for and outcomes of lung function deficits throughout the lifespan.” 2019. Doctoral Dissertation, University of Melbourne. Accessed March 03, 2021. http://hdl.handle.net/11343/225032.

MLA Handbook (7^th Edition):

Bui, Dinh Son. “Risk factors for and outcomes of lung function deficits throughout the lifespan.” 2019. Web. 03 Mar 2021.

Vancouver:

Bui DS. Risk factors for and outcomes of lung function deficits throughout the lifespan. [Internet] [Doctoral dissertation]. University of Melbourne; 2019. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11343/225032.

Council of Science Editors:

Bui DS. Risk factors for and outcomes of lung function deficits throughout the lifespan. [Doctoral Dissertation]. University of Melbourne; 2019. Available from: http://hdl.handle.net/11343/225032

Universidade do Rio Grande do Sul

13. Friedrich, Luciana. Crescimento pulmonar em lactentes pré-termo sadios.

Degree: 2007, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/12641

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Justificativa do estudo: Existem evidências crescentes de redução de fluxos expiratórios em crianças nascidas pré-termo sem doenças respiratórias neonatais. O seguimento destes pacientes sugere que… (more)

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Justificativa do estudo: Existem evidências crescentes de redução de fluxos expiratórios em crianças nascidas pré-termo sem doenças respiratórias neonatais. O seguimento destes pacientes sugere que haja um catch-up de função pulmonar durante os primeiros anos de vida. Objetivos: Medir a função pulmonar de lactentes pré-termo sadios (sem patologias respiratórias neonatais) durante os primeiros dois anos de vida e analisar o efeito de dados perinatais no crescimento pulmonar destes pacientes. Delineamento: Estudo de coorte prospectivo com controles históricos. Pacientes e métodos: Foram recrutados neonatos pré-termo menores de 34 semanas de idade gestacional que não necessitaram de ventilação mecânica ou oxigenoterapia prolongada no período neonatal. O grupo controle consistiu de lactentes normais a termo menores de três anos. Duas medidas longitudinais de função pulmonar foram realizadas após 40 semanas e após os 12 meses de idade corrigida., através da técnica de Compressão Torácica Rápida Os principais testes estatísticos utilizados na análise dos dados foram a análise de covariância e a regressão linear. Resultados: Os lactentes pré-termo apresentaram redução nos fluxos expiratórios forçados, com volumes pulmonares normais, em ambos os testes. A melhora da função pulmonar entre os testes foi semelhante entre os dois grupos. O uso breve de oxigênio no período neonatal foi associado a uma melhora nos fluxos e a exposição ao tabagismo antes do nascimento, a fluxos mais reduzidos. Conclusões: Fluxos expiratórios persistentemente reduzidos na presença de capacidades vitais normais e a ausência de catch-up no crescimento pulmonar dos pacientes pré-termo sugerem que o nascimento pré-termo per se está relacionado a um desenvolvimento pulmonar alterado.

Rationale: There is growing evidence of reduced expiratory flows in preterm infants without respiratory troubles at birth. Longitudinal follow-up of these children suggests there is a catch-up of lung function in the first years of life. Objectives: To measure lung function in healthy preterm infants (without neonatal respiratory disease) in the first two years of life, and analyze the effect of perinatal variables in lung growth of these group. Study: Prospective cohort study with historic controls. Patients and methods: Preterm infants less than 34 gestational weeks and with no need for mechanical ventilation or prolonged oxygen support after birth were recruited. Controls consisted of less than three year-old healthy term infants. Longitudinal lung function measures were carried out after 40 weeks and 12 months of corrected gestational age, through the Rapid Thoracic Compression Technique. The main statistical tests used were covariance analysis and linear regression. Results: Preterm infants showed reduced expiratory flows and normal lung volumes in both tests. The improvement of lung function between the two tests were similar in both groups. Brief oxygen use in the neonatal period was associated with better flows, and antenatal smoking exposure was associated to…

Advisors/Committee Members: Goldani, Marcelo Zubaran.

Subjects/Keywords: Lung growth; Prematuro; Espirometria; Spirometry; Pulmão; Prematurity; Lung function; Crescimento e desenvolvimento

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APA (6^th Edition):

Friedrich, L. (2007). Crescimento pulmonar em lactentes pré-termo sadios. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/12641

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Friedrich, Luciana. “Crescimento pulmonar em lactentes pré-termo sadios.” 2007. Thesis, Universidade do Rio Grande do Sul. Accessed March 03, 2021. http://hdl.handle.net/10183/12641.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Friedrich, Luciana. “Crescimento pulmonar em lactentes pré-termo sadios.” 2007. Web. 03 Mar 2021.

Vancouver:

Friedrich L. Crescimento pulmonar em lactentes pré-termo sadios. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2007. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10183/12641.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Friedrich L. Crescimento pulmonar em lactentes pré-termo sadios. [Thesis]. Universidade do Rio Grande do Sul; 2007. Available from: http://hdl.handle.net/10183/12641

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova

14. Pinto, Ana Rita da Conceição. Exposição ocupacional a partículas e função respiratória em trabalhadores industriais.

Degree: 2012, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9462

►

RESUMO - Num local de trabalho, em especial num ambiente industrial, podemos estar expostos a diversos tipos de riscos profissionais. A exposição ocupacional a partículas… (more)

Subjects/Keywords: Exposição; Partículas; Função Respiratória; Doenças Respiratórias Profissionais; Exposure; Particles; Lung Function; Professional Lung Diseases

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APA (6^th Edition):

Pinto, A. R. d. C. (2012). Exposição ocupacional a partículas e função respiratória em trabalhadores industriais. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9462

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pinto, Ana Rita da Conceição. “Exposição ocupacional a partículas e função respiratória em trabalhadores industriais.” 2012. Thesis, Universidade Nova. Accessed March 03, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9462.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pinto, Ana Rita da Conceição. “Exposição ocupacional a partículas e função respiratória em trabalhadores industriais.” 2012. Web. 03 Mar 2021.

Vancouver:

Pinto ARdC. Exposição ocupacional a partículas e função respiratória em trabalhadores industriais. [Internet] [Thesis]. Universidade Nova; 2012. [cited 2021 Mar 03]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9462.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pinto ARdC. Exposição ocupacional a partículas e função respiratória em trabalhadores industriais. [Thesis]. Universidade Nova; 2012. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9462

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Louisville

15. Negahdar, Mohammadreza, 1979-. 3-D lung deformation and function from respiratory-gated 4-D x-ray CT images : application to radiation treatment planning.

Degree: PhD, 2012, University of Louisville

URL: 10.18297/etd/1048 ; https://ir.library.louisville.edu/etd/1048

► Many lung diseases or injuries can cause biomechanical or material property changes that can alter lung function. While the mechanical changes associated with the change… (more)

▼ Many lung diseases or injuries can cause biomechanical or material property changes that can alter lung function. While the mechanical changes associated with the change of the material properties originate at a regional level, they remain largely asymptomatic and are invisible to global measures of lung function until they have advanced significantly and have aggregated. In the realm of external beam radiation therapy of patients suffering from lung cancer, determination of patterns of pre- and post-treatment motion, and measures of regional and global lung elasticity and function are clinically relevant. In this dissertation, we demonstrate that 4-D CT derived ventilation images, including mechanical strain, provide an accurate and physiologically relevant assessment of regional pulmonary function which may be incorporated into the treatment planning process. Our contributions are as follows: (i) A new volumetric deformable image registration technique based on 3-D optical flow (MOFID) has been designed and implemented which permits the possibility of enforcing physical constraints on the numerical solutions for computing motion field from respiratory-gated 4-D CT thoracic images. The proposed optical flow framework is an accurate motion model for the thoracic CT registration problem. (ii) A large displacement landmark-base elastic registration method has been devised for thoracic CT volumetric image sets containing large deformations or changes, as encountered for example in registration of pre-treatment and post-treatment images or multi-modality registration. (iii) Based on deformation maps from MOFIO, a novel framework for regional quantification of mechanical strain as an index of lung functionality has been formulated for measurement of regional pulmonary function. (iv) In a cohort consisting of seven patients with non-small cell lung cancer, validation of physiologic accuracy of the 4-0 CT derived quantitative images including Jacobian metric of ventilation, Vjac, and principal strains, (V?1, V?2, V?3, has been performed through correlation of the derived measures with SPECT ventilation and perfusion scans. The statistical correlations with SPECT have shown that the maximum principal strain pulmonary function map derived from MOFIO, outperforms all previously established ventilation metrics from 40-CT. It is hypothesized that use of CT -derived ventilation images in the treatment planning process will help predict and prevent pulmonary toxicity due to radiation treatment. It is also hypothesized that measures of regional and global lung elasticity and function obtained during the course of treatment may be used to adapt radiation treatment. Having objective methods with which to assess pre-treatment global and regional lung function and biomechanical properties, the radiation treatment dose can potentially be escalated to improve tumor response and local control. Advisors/Committee Members: Amini, Amir A..

Subjects/Keywords: Medical imaging; Lung function; Image registration; 4-D CT; Lung cancer; Radiation treatment

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APA (6^th Edition):

Negahdar, Mohammadreza, 1. (2012). 3-D lung deformation and function from respiratory-gated 4-D x-ray CT images : application to radiation treatment planning. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/1048 ; https://ir.library.louisville.edu/etd/1048

Chicago Manual of Style (16^th Edition):

Negahdar, Mohammadreza, 1979-. “3-D lung deformation and function from respiratory-gated 4-D x-ray CT images : application to radiation treatment planning.” 2012. Doctoral Dissertation, University of Louisville. Accessed March 03, 2021. 10.18297/etd/1048 ; https://ir.library.louisville.edu/etd/1048.

MLA Handbook (7^th Edition):

Negahdar, Mohammadreza, 1979-. “3-D lung deformation and function from respiratory-gated 4-D x-ray CT images : application to radiation treatment planning.” 2012. Web. 03 Mar 2021.

Vancouver:

Negahdar, Mohammadreza 1. 3-D lung deformation and function from respiratory-gated 4-D x-ray CT images : application to radiation treatment planning. [Internet] [Doctoral dissertation]. University of Louisville; 2012. [cited 2021 Mar 03]. Available from: 10.18297/etd/1048 ; https://ir.library.louisville.edu/etd/1048.

Council of Science Editors:

Negahdar, Mohammadreza 1. 3-D lung deformation and function from respiratory-gated 4-D x-ray CT images : application to radiation treatment planning. [Doctoral Dissertation]. University of Louisville; 2012. Available from: 10.18297/etd/1048 ; https://ir.library.louisville.edu/etd/1048

University of Missouri – Columbia

16. Jaafar, Rani. Predicting macroscale response of unsaturated sands from microscale analysis and simple geotechnical testing.

Degree: 2012, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/36672

► A large portion, if not the majority, of conditions encountered in geotechnical engineering practice involves unsaturated soil. Practical problems include precipitation-induced slope stability failures, expansive… (more)

Subjects/Keywords: unsaturated soil; soil-water characteristic curve; hydraulic conductivity function; strength parameters

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APA (6^th Edition):

Jaafar, R. (2012). Predicting macroscale response of unsaturated sands from microscale analysis and simple geotechnical testing. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/36672

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jaafar, Rani. “Predicting macroscale response of unsaturated sands from microscale analysis and simple geotechnical testing.” 2012. Thesis, University of Missouri – Columbia. Accessed March 03, 2021. http://hdl.handle.net/10355/36672.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jaafar, Rani. “Predicting macroscale response of unsaturated sands from microscale analysis and simple geotechnical testing.” 2012. Web. 03 Mar 2021.

Vancouver:

Jaafar R. Predicting macroscale response of unsaturated sands from microscale analysis and simple geotechnical testing. [Internet] [Thesis]. University of Missouri – Columbia; 2012. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10355/36672.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jaafar R. Predicting macroscale response of unsaturated sands from microscale analysis and simple geotechnical testing. [Thesis]. University of Missouri – Columbia; 2012. Available from: http://hdl.handle.net/10355/36672

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

17. Freitas, Cledna da Rocha Barreto de. Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória .

Degree: 2011, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/16698

► Background: Obesity leads to alteration of lung volumes and capacities due to accumulation of fat in the chest wall and abdomen. Few studies have shown… (more)

Subjects/Keywords: Obesidade; Cirurgia bariátrica; Função pulmonar; Obesity; Bariatric surgery; Lung function

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APA (6^th Edition):

Freitas, C. d. R. B. d. (2011). Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/16698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Freitas, Cledna da Rocha Barreto de. “Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória .” 2011. Thesis, Universidade do Rio Grande do Norte. Accessed March 03, 2021. http://repositorio.ufrn.br/handle/123456789/16698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Freitas, Cledna da Rocha Barreto de. “Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória .” 2011. Web. 03 Mar 2021.

Vancouver:

Freitas CdRBd. Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2011. [cited 2021 Mar 03]. Available from: http://repositorio.ufrn.br/handle/123456789/16698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Freitas CdRBd. Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória . [Thesis]. Universidade do Rio Grande do Norte; 2011. Available from: http://repositorio.ufrn.br/handle/123456789/16698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

18. Eeftens, M.R. Spatial contrasts in air pollution and the effects on lung function in children.

Degree: 2015, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/315552

► Within the framework of the ESCAPE project (European Study of Cohorts for Air Pollution Effects), we aimed to characterize and explain spatial contrasts in ambient… (more)

▼ Within the framework of the ESCAPE project (European Study of Cohorts for Air Pollution Effects), we aimed to characterize and explain spatial contrasts in ambient air pollution within and between European study areas. Following a standard protocol, project partners selected “street” and “background” measurement sites in 36 study areas, and measured using identical equipment. NO2 and NOX measurements were available from 40 different sites in each area (80 in The Netherlands/Belgium and Catalunya). PM2.5 (particles <2.5 µm), PM2.5 absorbance (the “blackness” of PM2.5 filters; an indicator for soot), PM10 (particles <10 µm) and PMcoarse (PM10 minus PM2.5) measurements were available for 20 of those areas, for a subset of 20 sites per area (40 in The Netherlands/Belgium and Catalunya). Significant contrasts between street and background concentrations were seen for all pollutants, but most clearly for NO2 and NOX. The measured concentrations formed the basis for the development of land use regression (LUR) models for each study area. LUR models for PM2.5, PM2.5 absorbance, PM10 and PMcoarse were developed by evaluating which environmental factors (represented by variables derived from a Geographic Information System (GIS)) were best able to explain the spatial variability in pollution concentration. Derived LUR models explained a moderate to high portion of variance for all pollutants using predictors related to traffic intensity, population density and nearby industrial and harbour sites. LUR models cannot accurately predict the high concentrations measured in urban canyons: narrow streets with (relatively) tall buildings. Using 3-dimensional building data and GIS, we derived four indicators for this canyon effect, among which the SkyView Factor (the total fraction of sky visible from the measurement site). Basic LUR models were developed based on NO2 and NOX data from 132 sites in the Netherlands. Although consideration of the canyon indicators increased the explained variance only modestly, the P10-P90 range of the SkyView Factor explained substantial concentration differences for both NO2 (5.6 μg/m³)and NOX (10.9 μg/m³). Particulate matter is a heterogeneous mixture of particles which differ in size, shape and composition and hence –presumably- toxicity. We estimated long-term exposure to eight elemental constituents of particulate matter (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc) at the homes of 4659 children involved in five birth cohorts. FEV1 (forced expiratory volume in the first second of exhalation) was determined when the children were 6 or 8 years old. After combining cohort-specific findings into a meta-analysis, we found a small decrease in FEV1 associated with exposure to nickel and sulphur. However, heterogeneity was larger for the various PM constituents than for PM10 and PM2.5 mass, and low FEV1 was more consistently associated with PM mass. Recent advancements in the application of LUR models have targeted the concentration data, the predictor variables, the… Advisors/Committee Members: Brunekreef, B., Hoek, G., Beelen, R.M.J..

Subjects/Keywords: Air pollution; Particulate matter; Street canyon; Modelling; Lung function

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APA (6^th Edition):

Eeftens, M. R. (2015). Spatial contrasts in air pollution and the effects on lung function in children. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/315552

Chicago Manual of Style (16^th Edition):

Eeftens, M R. “Spatial contrasts in air pollution and the effects on lung function in children.” 2015. Doctoral Dissertation, Universiteit Utrecht. Accessed March 03, 2021. http://dspace.library.uu.nl:8080/handle/1874/315552.

MLA Handbook (7^th Edition):

Eeftens, M R. “Spatial contrasts in air pollution and the effects on lung function in children.” 2015. Web. 03 Mar 2021.

Vancouver:

Eeftens MR. Spatial contrasts in air pollution and the effects on lung function in children. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2015. [cited 2021 Mar 03]. Available from: http://dspace.library.uu.nl:8080/handle/1874/315552.

Council of Science Editors:

Eeftens MR. Spatial contrasts in air pollution and the effects on lung function in children. [Doctoral Dissertation]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/315552

University of California – Berkeley

19. Gale, Sara Lynn. The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma.

Degree: Epidemiology, 2012, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/6h38n5tn

► To investigate the extent to which traffic exposure affects the lung function of children with asthma and how local neighborhood factors may modify this relation,… (more)

▼ To investigate the extent to which traffic exposure affects the lung function of children with asthma and how local neighborhood factors may modify this relation, a merge of epidemiologic, environmental health and geographic methods is necessary. People and places are linked; therefore, it is necessary to consider place-effects on health as well as environmental exposures. The Fresno Asthmatic Children's Environment Study (FACES) is a longitudinal cohort study of children with asthma in Fresno, California that followed participants from 2000-2008 to explore short-term and long-term effects of ambient air pollution on lung function (as measured by spirometry, wheeze, and asthma symptoms). With publicly available data on traffic counts in Fresno, CA from 2000-2008, I built a spatial model of traffic exposure that varies both temporally and spatially for the FACES cohort. To capture and quantify neighborhood characteristics, I constructed individual neighborhoods based on global positioning software (GPS) data and walking distances around participant homes. To evaluate neighborhood deprivation, I collected geographic information system (GIS) data on parks, grocery stores, bus stops, etc. from publicly available sources and created an index based on Item Response Theory. To assess the marginal risk difference of lung function among children with asthma exposed to high levels of traffic pollution and those exposed to lower levels of traffic pollution (as measured by traffic density), I apply semi-parametric causal inference methods and use Targeted Maximum Likelihood Estimation (TMLE). More FACES participants who live in high deprivation neighborhoods are also farther away from high traffic areas. Neighborhood deprivation, as defined by a combination of GIS variables in this study, does not track well with US Census poverty. The marginal change in lung function from exposure to high neighborhood traffic to lower neighborhood traffic, without stratification for neighborhood deprivation, is -0.233 (95% CI -0.338, -0.129). The results can be interpreted as – the average decrease of FEV1 is 0.233 L, or there is a 12% reduction in lung function. Either neighborhood deprivation does not modify the effect of traffic on lung function or there is not enough data to evaluate this type of effect modification. The findings indicate that neighborhood exposure to traffic adversely affects lung function among the FACES cohort of children with asthma.

Subjects/Keywords: Epidemiology; Environmental health; Air pollution; Asthma; Deprivation; Lung function; Neighborhood; Traffic

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APA (6^th Edition):

Gale, S. L. (2012). The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/6h38n5tn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gale, Sara Lynn. “The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma.” 2012. Thesis, University of California – Berkeley. Accessed March 03, 2021. http://www.escholarship.org/uc/item/6h38n5tn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gale, Sara Lynn. “The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma.” 2012. Web. 03 Mar 2021.

Vancouver:

Gale SL. The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma. [Internet] [Thesis]. University of California – Berkeley; 2012. [cited 2021 Mar 03]. Available from: http://www.escholarship.org/uc/item/6h38n5tn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gale SL. The Impact of Neighborhood Traffic Density and Deprivation on Lung Function Among Children with Asthma. [Thesis]. University of California – Berkeley; 2012. Available from: http://www.escholarship.org/uc/item/6h38n5tn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

20. Freitas, Cledna da Rocha Barreto de. Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória .

Degree: 2011, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/16698

► Background: Obesity leads to alteration of lung volumes and capacities due to accumulation of fat in the chest wall and abdomen. Few studies have shown… (more)

Subjects/Keywords: Obesidade; Cirurgia bariátrica; Função pulmonar; Obesity; Bariatric surgery; Lung function

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Freitas, C. d. R. B. d. (2011). Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória . (Masters Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/16698

Chicago Manual of Style (16^th Edition):

Freitas, Cledna da Rocha Barreto de. “Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória .” 2011. Masters Thesis, Universidade do Rio Grande do Norte. Accessed March 03, 2021. http://repositorio.ufrn.br/handle/123456789/16698.

MLA Handbook (7^th Edition):

Freitas, Cledna da Rocha Barreto de. “Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória .” 2011. Web. 03 Mar 2021.

Vancouver:

Freitas CdRBd. Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória . [Internet] [Masters thesis]. Universidade do Rio Grande do Norte; 2011. [cited 2021 Mar 03]. Available from: http://repositorio.ufrn.br/handle/123456789/16698.

Council of Science Editors:

Freitas CdRBd. Efeitos da perda de peso induzida pela cirurgia bariátrica sobre a função respiratória . [Masters Thesis]. Universidade do Rio Grande do Norte; 2011. Available from: http://repositorio.ufrn.br/handle/123456789/16698

21. Khanam, Ulfat Ara 1986-. ARE DIETARY FACTORS ASSOCIATED WITH LUNG FUNCTION IN CANADIAN ADULTS?.

Degree: 2017, University of Saskatchewan

URL: http://hdl.handle.net/10388/8327

► Background: Assessment of lung function by spirometry is helpful for evaluating lung health. It provides precise measurements of air volumes and flows useful for diagnosis… (more)

▼ Background: Assessment of lung function by spirometry is helpful for evaluating lung health. It provides precise measurements of air volumes and flows useful for diagnosis and monitoring of respiratory diseases. Respiratory diseases (including asthma and COPD) are some of the major causes of school and work absenteeism, hospital admission, disability, and death. Diet is a modifiable risk factor that has been associated with various respiratory outcomes but has been studied minimally in relation to lung function. Purpose: The purpose of this study was to explore the impact of dietary factors and nutrient biomarkers on lung function among Canadian adults (18 years and older). Methods: The Canadian Health Measures Survey (CHMS) is a national and ongoing health survey of Canadians led by Statistics Canada. CHMS uses a repeated cross-sectional multi-stage survey design. Data collection included a combination of a computer-assisted personal interview and physical assessment. The first Cycle (2007-2009) included N=3726, the second Cycle (2009-2011) included N= 3873, and the third Cycle (2012-2013) included N= 3397 adult Canadians. The physical measures were conducted at Mobile Examination Centers (MEC) specifically designed for the study. Spirometry measurement was completed by the eligible participants following spirometric guidelines of the American Thoracic Society (ATS). The household and clinic questionnaires were used to assess individual dietary factors, Canada Food Guide, and Modified Mediterranean Diet Score separately for each of the Cycles. Biomarker assessment was done by using blood samples. Association analyses were completed using multiple linear regression adjusting for age, sex, and height as well as other confounders using sampling weights. Bootstrapping variables supplied by Statistics Canada were used to calculate variances. Results: The overall mean percent predicted values for FVC and FEV1 were 98% and 95%, respectively. The associations between dietary consumption and lung function were relatively inconsistent. However, in both Cycles 1 and 2, consumption of dietary fat was associated with higher FVC (p<0.05). In all Cycles, most of the participants did not meet the daily requirement of Canada Food Guide and the “not meeting” the requirements were inconsistently associated with the lower lung function. The modified Mediterranean Diet Score was significantly associated with lower lung function in Cycle 3. Among the biomarkers, chloride was associated with higher FVC and FEV1 for all three Cycles (p<0.05). C-reactive protein was associated with lower FVC, FEV1, and FEF25-75% (Cycle 1, 3. p<0.05). Vitamin D was associated with higher FEV1 (Cycle 1, 3. p<0.05). Finally, Vitamin B12 was associated with lower FEV1 (Cycle 1, 3. p<0.05). Conclusion: Lung function characteristics shows good lung health of the general adult population based on the mean percent predicted values. Our study provides evidence that there is an association between dietary factors and lung function though there were some… Advisors/Committee Members: Lawson, Joshua A, Rennie, Donna C, Davis, Karen, Janzen, Bonnie.

Subjects/Keywords: Diet; Lung Function; adults; Canada Food Guide; Mediterranean Diet; Canada; CHMS

1 more image…

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APA (6^th Edition):

Khanam, U. A. 1. (2017). ARE DIETARY FACTORS ASSOCIATED WITH LUNG FUNCTION IN CANADIAN ADULTS?. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/8327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Khanam, Ulfat Ara 1986-. “ARE DIETARY FACTORS ASSOCIATED WITH LUNG FUNCTION IN CANADIAN ADULTS?.” 2017. Thesis, University of Saskatchewan. Accessed March 03, 2021. http://hdl.handle.net/10388/8327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Khanam, Ulfat Ara 1986-. “ARE DIETARY FACTORS ASSOCIATED WITH LUNG FUNCTION IN CANADIAN ADULTS?.” 2017. Web. 03 Mar 2021.

Vancouver:

Khanam UA1. ARE DIETARY FACTORS ASSOCIATED WITH LUNG FUNCTION IN CANADIAN ADULTS?. [Internet] [Thesis]. University of Saskatchewan; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10388/8327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Khanam UA1. ARE DIETARY FACTORS ASSOCIATED WITH LUNG FUNCTION IN CANADIAN ADULTS?. [Thesis]. University of Saskatchewan; 2017. Available from: http://hdl.handle.net/10388/8327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

22. Molter, Anna. Air pollution exposure and respiratory health in childhood.

Degree: PhD, 2012, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/air-pollution-exposure-and-respiratory-health-in-childhood(86388151-13d1-499d-be59-89d6d87e036f).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566556

► Asthma is the most common chronic disease in children and the effects of air pollution exposure on asthma and respiratory health in children have been… (more)

▼ Asthma is the most common chronic disease in children and the effects of air pollution exposure on asthma and respiratory health in children have been a growing concern over recent decades. Although a number of epidemiological studies have been carried out in this field, these have produced conflicting results. The aim of this study was to assess the effects of long term exposure to nitrogen dioxide (NO2) and particulate matter (PM10) on asthma prevalence and lung function in children. To achieve this, a novel exposure model was developed and evaluated, which allowed retrospective exposure assessment of children participating in a population based birth cohort study – the Manchester Asthma and Allergy Study (MAAS). MAAS is a prospective birth cohort study comprising 1185 children specifically designed to study asthma and allergies. Clinical follow up took place at ages 3, 5, 8 and 11 years. At each follow up parents completed questionnaires on asthma diagnosis and symptoms and children underwent skin prick tests for common allergens. Children’s specific airways resistance (sRaw, at ages 3, 5, 8, 11) and forced expiratory volume in one second (FEV1, at ages 5, 8, 11) were measured. At ages 5 and 11 years FEV1 was measured at baseline and after bronchodilator treatment. The exposure model developed during this study incorporated outdoor and indoor air pollution, spatio-temporal variation in air pollution and time-activity patterns of children. The model was based on the concept of microenvironmental exposure. It modelled personal exposure based on PM10 and NO2 concentrations in children’s home, school and journey microenvironments (MEs) and the length of time they spend in these MEs. Land use regression (LUR) models were used to model PM10 and NO2 concentrations in outdoor MEs. These LUR models were specifically developed for the Greater Manchester area. A novel method was used to develop the LUR models, which used the output from an air dispersion model as dependent variables in the regression analysis. Furthermore, a novel approach was used to obtain annual concentration of PM10 and NO2 from 1996 to 2010, which involved the recalibration of the LUR models for each year. A mass balance model and indoor to outdoor ratios were used to model concentrations in indoor MEs. The performance of the exposure model was evaluated through a personal monitoring study in schoolchildren attending a local secondary school. Children wore personal NO2 monitors for two consecutive days in four seasons. Parental questionnaires and time-activity diaries were used to obtain information for the exposure model and to model NO2 exposure for the same time period. The results showed good agreement between monitored and modelled NO2 concentrations (Normalised mean bias factor=-0.04). Multiple linear regression and generalised estimating equations (GEE) were used to assess the cross-sectional and longitudinal effect of modelled exposure on sRaw and FEV1 (as % predicted). Multiple logistic regression and GEE were used to assess the effect of…

Subjects/Keywords: 618.92; Air pollution; Exposure model; Childhood; Asthma; Lung function

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APA (6^th Edition):

Molter, A. (2012). Air pollution exposure and respiratory health in childhood. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/air-pollution-exposure-and-respiratory-health-in-childhood(86388151-13d1-499d-be59-89d6d87e036f).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566556

Chicago Manual of Style (16^th Edition):

Molter, Anna. “Air pollution exposure and respiratory health in childhood.” 2012. Doctoral Dissertation, University of Manchester. Accessed March 03, 2021. https://www.research.manchester.ac.uk/portal/en/theses/air-pollution-exposure-and-respiratory-health-in-childhood(86388151-13d1-499d-be59-89d6d87e036f).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566556.

MLA Handbook (7^th Edition):

Molter, Anna. “Air pollution exposure and respiratory health in childhood.” 2012. Web. 03 Mar 2021.

Vancouver:

Molter A. Air pollution exposure and respiratory health in childhood. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Mar 03]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/air-pollution-exposure-and-respiratory-health-in-childhood(86388151-13d1-499d-be59-89d6d87e036f).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566556.

Council of Science Editors:

Molter A. Air pollution exposure and respiratory health in childhood. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/air-pollution-exposure-and-respiratory-health-in-childhood(86388151-13d1-499d-be59-89d6d87e036f).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566556

23. McClean, Kathy Margaret. Nutrition, inflammation and lung function in middle-aged men.

Degree: PhD, 2010, Queen's University Belfast

URL: https://pure.qub.ac.uk/en/theses/nutrition-inflammation-and-lung-function-in-middleaged-men(a5ed7e6d-6c9a-45cf-b5f6-bc2b8fb84bba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527847

► Background: Forced expiratory volume in one second (FEV1) is an independent predictor of all-cause mortality and therefore variables which accelerate or slow FEV1 decline are… (more)

▼ Background: Forced expiratory volume in one second (FEV1) is an independent predictor of all-cause mortality and therefore variables which accelerate or slow FEV1 decline are of great potential importance to public health. Methods: From 1991 to 1994, 2745 men aged 50 to 59 years were recruited into the Belfast cohort of the Prospective Epidemiological Study of Myocardial Infarction (PRIME). 2010 of these men were rescreened at 10 years. At both time points, the men were assessed at a clinic appointment which involved blood sampling, questionnaires, anthropometric measurements and lung function by spirometry. Each individual spirometry trace (baseline and 10 year follow-up) was reviewed for validity using ATS/ERS criteria. Plasma levels of C-Reactive Protein (CRP), antioxidant vitamins (A and E) and carotenoids were measured in the stored blood samples. All statistical analyses were performed with SPSS version 15. Results: The 2745 men in the baseline cohort had a mean age of 54.8 years (SD 2.9) and 32.9% had never smoked. They were on average overweight with a mean body mass index of 26.3kg/m2 and a mean waist-hip ratio of 0.94. 1779 men had valid baseline lung function measurements by spirometry. Mean percent predicted FEV1 was 92% and mean percent predicted FVC was 96.9%. The baseline current smokers had the greatest decline in FEV1 over 10 years of 560 ml (SD 339 ml). Waist-hip ratio, body mass index and waist circumference were inversely associated with pulmonary function. FEV1 decline was related to the change in distribution of weight as well as to weight gain. Lung function and plasma C-Reactive Protein (CRP) concentrations were inversely related in both cross-sectional and longitudinal analyses. The presence of systemic inflammation was demonstrated, even in subjects with mildly reduced pulmonary function. There was also an association between annual change in CRP and annual decline in FEV1 and forced expiratory volume in one second (FVC) in the adjusted model in this population. Plasma levels of retinol, lutein, zeaxanthin, ß-cryptoxanthin, α-carotene and ß-carotene were positively correlated with lung function in the cross-sectional analysis. There were also some longitudinal associations between baseline retinol, zeaxanthin, β-cryptoxanthin and 10 year lung function. Self-reported fruit and vegetable intake was positively correlated with both lung function and plasma levels of antioxidants. Conclusion: In this population of middle-aged men from Northern Ireland, lung function and lung function decline as measured by FEV1 and FVC are related to body mass index, body weight distribution, lifestyle habits (smoking and alcohol intake), social status, subclinical inflammation and diet. This data supports the current public health advice regarding healthy eating, weight control and smoking cessation.

Subjects/Keywords: 612.3; lung function; CRP; nutrition

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APA (6^th Edition):

McClean, K. M. (2010). Nutrition, inflammation and lung function in middle-aged men. (Doctoral Dissertation). Queen's University Belfast. Retrieved from https://pure.qub.ac.uk/en/theses/nutrition-inflammation-and-lung-function-in-middleaged-men(a5ed7e6d-6c9a-45cf-b5f6-bc2b8fb84bba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527847

Chicago Manual of Style (16^th Edition):

McClean, Kathy Margaret. “Nutrition, inflammation and lung function in middle-aged men.” 2010. Doctoral Dissertation, Queen's University Belfast. Accessed March 03, 2021. https://pure.qub.ac.uk/en/theses/nutrition-inflammation-and-lung-function-in-middleaged-men(a5ed7e6d-6c9a-45cf-b5f6-bc2b8fb84bba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527847.

MLA Handbook (7^th Edition):

McClean, Kathy Margaret. “Nutrition, inflammation and lung function in middle-aged men.” 2010. Web. 03 Mar 2021.

Vancouver:

McClean KM. Nutrition, inflammation and lung function in middle-aged men. [Internet] [Doctoral dissertation]. Queen's University Belfast; 2010. [cited 2021 Mar 03]. Available from: https://pure.qub.ac.uk/en/theses/nutrition-inflammation-and-lung-function-in-middleaged-men(a5ed7e6d-6c9a-45cf-b5f6-bc2b8fb84bba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527847.

Council of Science Editors:

McClean KM. Nutrition, inflammation and lung function in middle-aged men. [Doctoral Dissertation]. Queen's University Belfast; 2010. Available from: https://pure.qub.ac.uk/en/theses/nutrition-inflammation-and-lung-function-in-middleaged-men(a5ed7e6d-6c9a-45cf-b5f6-bc2b8fb84bba).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527847

University of Minnesota

24. Kunisaki, Ken. Vitamin D status and longitudinal lung function decline in the Lung Health Study.

Degree: MS, Clinical Research, 2014, University of Minnesota

URL: http://hdl.handle.net/11299/162843

► Low vitamin D blood levels are postulated to be a risk factor for worse lung function, largely based on cross-sectional data. We sought to use… (more)

Subjects/Keywords: 25-hydroxyvitamin D; COPD; FEV1; FVC; Lung function; Vitamin D

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APA (6^th Edition):

Kunisaki, K. (2014). Vitamin D status and longitudinal lung function decline in the Lung Health Study. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/162843

Chicago Manual of Style (16^th Edition):

Kunisaki, Ken. “Vitamin D status and longitudinal lung function decline in the Lung Health Study.” 2014. Masters Thesis, University of Minnesota. Accessed March 03, 2021. http://hdl.handle.net/11299/162843.

MLA Handbook (7^th Edition):

Kunisaki, Ken. “Vitamin D status and longitudinal lung function decline in the Lung Health Study.” 2014. Web. 03 Mar 2021.

Vancouver:

Kunisaki K. Vitamin D status and longitudinal lung function decline in the Lung Health Study. [Internet] [Masters thesis]. University of Minnesota; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11299/162843.

Council of Science Editors:

Kunisaki K. Vitamin D status and longitudinal lung function decline in the Lung Health Study. [Masters Thesis]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/162843

University of Ontario Institute of Technology

25. O'Neill, Carley. The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction.

Degree: 2016, University of Ontario Institute of Technology

URL: http://hdl.handle.net/10155/711

► INTRODUCTION: Exercise induced bronchoconstriction (EIBC) occurs as a result of airway cooling and drying in adults with airway hyperresponsiveness (AHR). Continuous exercise leads to a… (more)

Subjects/Keywords: Bronchoconstriction; High intensity interval exercise; Lung function; Affect; Perceived exertion

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APA (6^th Edition):

O'Neill, C. (2016). The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction. (Thesis). University of Ontario Institute of Technology. Retrieved from http://hdl.handle.net/10155/711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

O'Neill, Carley. “The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction.” 2016. Thesis, University of Ontario Institute of Technology. Accessed March 03, 2021. http://hdl.handle.net/10155/711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

O'Neill, Carley. “The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction.” 2016. Web. 03 Mar 2021.

Vancouver:

O'Neill C. The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction. [Internet] [Thesis]. University of Ontario Institute of Technology; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10155/711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

O'Neill C. The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction. [Thesis]. University of Ontario Institute of Technology; 2016. Available from: http://hdl.handle.net/10155/711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ontario Institute of Technology

26. Good, Joshua. The acute response to sprint interval exercise and moderate intensity continuous exercise in adults with and without airway hyperresponsiveness.

Degree: 2017, University of Ontario Institute of Technology

URL: http://hdl.handle.net/10155/837

► Introduction: Sprint interval exercise (SIE) has been proposed as a time efficient way to improve physical activity levels; however, SIE has not been studied in… (more)

Subjects/Keywords: Sprint interval exercise; Airway hyperresponsiveness; Lung function; Asthma; Affect

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Good, J. (2017). The acute response to sprint interval exercise and moderate intensity continuous exercise in adults with and without airway hyperresponsiveness. (Thesis). University of Ontario Institute of Technology. Retrieved from http://hdl.handle.net/10155/837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Good, Joshua. “The acute response to sprint interval exercise and moderate intensity continuous exercise in adults with and without airway hyperresponsiveness.” 2017. Thesis, University of Ontario Institute of Technology. Accessed March 03, 2021. http://hdl.handle.net/10155/837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Good, Joshua. “The acute response to sprint interval exercise and moderate intensity continuous exercise in adults with and without airway hyperresponsiveness.” 2017. Web. 03 Mar 2021.

Vancouver:

Good J. The acute response to sprint interval exercise and moderate intensity continuous exercise in adults with and without airway hyperresponsiveness. [Internet] [Thesis]. University of Ontario Institute of Technology; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10155/837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Good J. The acute response to sprint interval exercise and moderate intensity continuous exercise in adults with and without airway hyperresponsiveness. [Thesis]. University of Ontario Institute of Technology; 2017. Available from: http://hdl.handle.net/10155/837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iowa

27. Du, Kaifang. Regional pulmonary function analysis using image registration.

Degree: MS, Biomedical Engineering, 2011, University of Iowa

URL: https://ir.uiowa.edu/etd/953

► Lung function depends on the expansion and contraction of lung tissue during the respiratory cycle. The measurement of regional pulmonary function is of great… (more)

Subjects/Keywords: 4DCT; Image registration; Lung; Pulmonary function; Ventilation; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Du, K. (2011). Regional pulmonary function analysis using image registration. (Masters Thesis). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/953

Chicago Manual of Style (16^th Edition):

Du, Kaifang. “Regional pulmonary function analysis using image registration.” 2011. Masters Thesis, University of Iowa. Accessed March 03, 2021. https://ir.uiowa.edu/etd/953.

MLA Handbook (7^th Edition):

Du, Kaifang. “Regional pulmonary function analysis using image registration.” 2011. Web. 03 Mar 2021.

Vancouver:

Du K. Regional pulmonary function analysis using image registration. [Internet] [Masters thesis]. University of Iowa; 2011. [cited 2021 Mar 03]. Available from: https://ir.uiowa.edu/etd/953.

Council of Science Editors:

Du K. Regional pulmonary function analysis using image registration. [Masters Thesis]. University of Iowa; 2011. Available from: https://ir.uiowa.edu/etd/953

University of Melbourne

28. Waidyatillake , Nilakshi Tharanga. Association between early life liquid diet and allergic disease and lung function outcomes.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/112627

► During my doctoral work I have investigated the effect of early life liquid diet (duration of breastfeeding, fatty acid composition of breast milk and formula… (more)

▼ During my doctoral work I have investigated the effect of early life liquid diet (duration of breastfeeding, fatty acid composition of breast milk and formula feeding) on allergic diseases and lung function outcomes during late childhood and adolescence, including assessment of possible mediators for these associations. Worldwide, the prevalence of allergic diseases has increased over recent decades. Australia has a high prevalence of these conditions. Allergic diseases are immune mediated and the maturation of the immune system occurs during early life. It is believed that gene and environment factors play a major role in developing or protecting against these diseases. Early life exposures have been hypothesised to influence the risk of developing allergic diseases, as they may have an impact on the developing immune system. While it is currently not clear how to reduce the incidence of allergic disease and improve the lung function outcomes, it is possible that modification of early life dietary exposures may play a role. The focus of my doctoral work is to explore the associations between early life liquid diet (breast and formula feeding) and allergic disease (asthma, eczema and allergic rhinitis) and lung function outcomes. The aim of this work is to determine if modification of early life liquid diet (breast milk and formula milk) may influence the risk of allergic diseases and later childhood lung function outcomes, which may then inform preventive strategies. The main liquids that an infant is exposed to in the first months of life are breast milk and formula milk. It is plausible that these first dietary exposures can impact on allergic disease outcomes. It is recommended by many health care organisations that a baby be exclusively breastfed for at least four months, while some organisations recommend six months of exclusive breastfeeding. Despite these recommendations, the actual duration of breastfeeding remains quite variable. The constituents of breast milk change due to a variety of reasons, such as mother’s diet and the needs of the child. Breast milk, especially colostrum, is rich in biologically active substances. Infant formulas can contain different base protein sources and variable degree of hydrolysis. These differences in the constituents of breast milk and between infant formulas may potentially influence the incidence of allergic disease. Within my thesis, I have both used systematic reviews of the published and utilised the data arising from the Melbourne Atopy cohort Study (n=620) to address key gaps in the evidence base of early life liquid diet and allergic diseases and lung function outcomes. In brief, Melbourne Atopy Cohort Study (MACS) started as a randomised controlled trial of three different types of formula (soy, partially hydrolysed whey and a conventional cows’ milk formula). Only infants with first degree relative with a family history of allergic diseases were eligible to be enrolled in the MACS. While the MACS commenced as a randomised controlled trial, I…

Subjects/Keywords: early life liquid diet; allergic disease; lung function

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Waidyatillake , N. T. (2016). Association between early life liquid diet and allergic disease and lung function outcomes. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/112627

Chicago Manual of Style (16^th Edition):

Waidyatillake , Nilakshi Tharanga. “Association between early life liquid diet and allergic disease and lung function outcomes.” 2016. Doctoral Dissertation, University of Melbourne. Accessed March 03, 2021. http://hdl.handle.net/11343/112627.

MLA Handbook (7^th Edition):

Waidyatillake , Nilakshi Tharanga. “Association between early life liquid diet and allergic disease and lung function outcomes.” 2016. Web. 03 Mar 2021.

Vancouver:

Waidyatillake NT. Association between early life liquid diet and allergic disease and lung function outcomes. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11343/112627.

Council of Science Editors:

Waidyatillake NT. Association between early life liquid diet and allergic disease and lung function outcomes. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/112627

29. Tham, Rachel. The contribution of outdoor fungal spores to child and adolescent asthma hospitalisations: lung function and airway inflammation.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/191669

► Outdoor fungal spores are among the most common aerobiological particles in the air we breathe. Although a limited number of outdoor fungal species are recognised… (more)

▼ Outdoor fungal spores are among the most common aerobiological particles in the air we breathe. Although a limited number of outdoor fungal species are recognised as exacerbating agents of a number of allergic and respiratory conditions, their contribution towards asthma exacerbation is unclear, particularly among children and adolescents. Moreover, we have limited understanding of the impacts that inhaled fungal spores have on lung function or airway inflammation, which may be pre-clinical signs of asthma exacerbation. Therefore the aim of my doctoral research is to examine whether there are associations between common outdoor fungal spores and child and adolescent asthma hospitalisations, and also to explore if short term exposure to ambient fungal spores is associated with lower lung function or airway inflammation. In Chapter 2, a comprehensive literature review highlights that there are significant knowledge gaps in the contribution of outdoor fungal spores to child and adolescent asthma hospitalisations, lung function and airway inflammation. In order to address some of these gaps, my specific research objectives of this doctoral research were to: (a) systematically synthesise the current evidence as to whether outdoor fungal spores were significant triggers of child and adolescent asthma exacerbations resulting in health service attendances; (b) investigate if there were associations between short term exposure to outdoor fungal spores and child and adolescent asthma hospitalisations; (c) explore if any of these associations were modified by air pollutants, grass pollen, age group, sex, presence of human rhinovirus infection, or fungal sensitisation status; (d) investigate if there were associations between outdoor fungal spores and lower lung function or airway inflammation, and (e) explore if any associations were modified by air pollutants or pollen, age group or fungal sensitisation status. In Chapter 3, my systematic review found that only a small number of studies have been conducted, predominantly in countries located in the northern hemisphere. Children with fungal sensitisation appeared to be at greater risk of asthma hospitalisations. Severity of asthma exacerbation may vary between fungal spore taxa. There were inconsistent findings, possibly due to the lack of accounting for other significant triggers of asthma exacerbations. In Chapter 5, my ecological case-crossover study of child and adolescent asthma hospitalisations in south-west Sydney found that there were associations with Coprinus, Periconia, Chaetomium, Ganoderma and Cerebella, with same day and lagged effects. There was evidence of effect modification by sex, with girls demonstrating stronger associations with Cladosporium, Coprinus and Chaetomium than boys. Age also acted as an effect modifier with older adolescents, demonstrating stronger associations with Coprinus and Ustilago/smuts than those aged under 14 years. In Chapter 6, my case-crossover study of child and adolescent asthma hospitalisations in Melbourne found…

Subjects/Keywords: outdoor fungal spores; asthma hospitalisations; lung function; airway inflammation; epidemiology

10 more images…

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APA (6^th Edition):

Tham, R. (2017). The contribution of outdoor fungal spores to child and adolescent asthma hospitalisations: lung function and airway inflammation. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/191669

Chicago Manual of Style (16^th Edition):

Tham, Rachel. “The contribution of outdoor fungal spores to child and adolescent asthma hospitalisations: lung function and airway inflammation.” 2017. Doctoral Dissertation, University of Melbourne. Accessed March 03, 2021. http://hdl.handle.net/11343/191669.

MLA Handbook (7^th Edition):

Tham, Rachel. “The contribution of outdoor fungal spores to child and adolescent asthma hospitalisations: lung function and airway inflammation.” 2017. Web. 03 Mar 2021.

Vancouver:

Tham R. The contribution of outdoor fungal spores to child and adolescent asthma hospitalisations: lung function and airway inflammation. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11343/191669.

Council of Science Editors:

Tham R. The contribution of outdoor fungal spores to child and adolescent asthma hospitalisations: lung function and airway inflammation. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/191669

University of Melbourne

30. Aldakheel, Fahad Mohammed. Associations between biomarkers in exhaled breath condensate (EBC) and allergic disease phenotypes and lung function.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/123893

► Asthma is a common chronic disorder of the airways that involves a complex interaction of airflow obstruction, bronchial hyperresponsiveness and underlying airway inflammation. It is… (more)

▼ Asthma is a common chronic disorder of the airways that involves a complex interaction of airflow obstruction, bronchial hyperresponsiveness and underlying airway inflammation. It is increasingly clear that asthma is a heterogeneous group of conditions (phenotypes) with common symptoms. The underlying mechanisms of different phenotypes are not clearly understood and the treatment responsiveness and causative factors are likely to vary between phenotypes. The increasing interest in airway inflammatory biomarkers assessment has led to the development and evolution of tools to measure these biomarkers which identify various asthma phenotypes. Exhaled breath condensate (EBC) is a totally non-invasive, easy to perform, feasible and inexpensive method for sampling lung and airways fluid, which reflects the airway epithelial lining fluid (ELF). EBC comprises a variety of airway inflammatory mediators, such as oxidative stress and pH, which provides non-invasive indicators of ongoing biochemical and inflammatory activity in the airways. Although EBC samples the entire respiratory tract from the mouth to the alveoli, the precise origin of each sampled molecule cannot be determined. A number of studies have assessed the relationship between EBC biomarkers and adult airway diseases, such as asthma. However, these studies have had limited sample sizes and, as a result, were unable to compare associations between numerous phenotypes of airway diseases. It remains possible that the associations with EBC biomarkers may change with age, but this has not been examined in a single study using the same methods. Furthermore, previous studies have been conducted in clinical populations rather than epidemiologic settings. Therefore, the overall aim of this PhD research was to assess the associations between oxidative stress biomarkers and pH in EBC and asthma phenotypes, rhinitis phenotypes, atopic sensitisation, lung function and objective markers of airway inflammation, including bronchial hyperresponsiveness (BHR) and the fraction of exhaled nitric oxide (FeNO), in both the early adulthood and middle-aged groups. Within this thesis, cross-sectional analyses nested within the two Australian longitudinal studies have been performed. These studies are: (1) The Melbourne Atopy Cohort Study (MACS), a study of individuals with a family history of allergic disease (defined as the early adulthood group in this thesis); and (2) The Tasmanian Longitudinal Health Study (TAHS), a population-based study (defined as the middle-aged group in this thesis). EBC samples were collected at the 18-year follow-up of MACS and the BHR LAB Study of the 5th-decade follow-up of TAHS. Using these data, this thesis contributes knowledge to the field, specifically addressing the following issues: Methodological issues from the laboratory analysis of EBC biomarkers Findings from this doctoral research showed that EBC biomarkers were influenced by the long period of storage, particularly for hydrogen peroxide (H2O2). The vast majority of analysed samples…

Subjects/Keywords: EBC; NOx; pH; allergy; asthma; rhinitis; lung function

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aldakheel, F. M. (2016). Associations between biomarkers in exhaled breath condensate (EBC) and allergic disease phenotypes and lung function. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/123893

Chicago Manual of Style (16^th Edition):

Aldakheel, Fahad Mohammed. “Associations between biomarkers in exhaled breath condensate (EBC) and allergic disease phenotypes and lung function.” 2016. Doctoral Dissertation, University of Melbourne. Accessed March 03, 2021. http://hdl.handle.net/11343/123893.

MLA Handbook (7^th Edition):

Aldakheel, Fahad Mohammed. “Associations between biomarkers in exhaled breath condensate (EBC) and allergic disease phenotypes and lung function.” 2016. Web. 03 Mar 2021.

Vancouver:

Aldakheel FM. Associations between biomarkers in exhaled breath condensate (EBC) and allergic disease phenotypes and lung function. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/11343/123893.

Council of Science Editors:

Aldakheel FM. Associations between biomarkers in exhaled breath condensate (EBC) and allergic disease phenotypes and lung function. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/123893

Open Access Theses and Dissertations