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Diabetes is associated with endothelial dysfunction and several cardiovascular disorders, such as systemic arterial hypertension. Moreover, hypertension and diabetes coexist very frequently, as 60-65% of diabetics are hypertensive. The coexistence of hypertension and diabetes can reduce endothelium-mediated vasodilatation, which can be partially explained by a reduced production of nitric oxide (NO) or a decreased response to NO in the vascular smooth muscle. On the other hand, it has been shown that a single session of exercise can promote significant reductions in blood pressure (BP). This occurrence is known as post-exercise hypotension (PEH) and appears to be associated with the activity of the kallikrein-kinin system and release of NO. Although studies have observed PEH in individuais with T2D the molecular mechanisms have not been fully elucidated. ln addition, the prescription of exercise intensities based on lactate threshold (L T) has been suggested for individuais with T2D.Moreover, in spite of previous studies showing that individuais with T2D exhibit PEH when exercising at intensities around LT , There is evidence that subjects with T2D exhibit lower plasma kallikrein activity (PKA) compared to healthy individuais, suggesting that lower NO release and reduced endothelium-dependent vasodilation would be occurring in response to exercise for this population. However, no investigations were made on the integrated responses of PKA, BK, dessArg9-BK and NO and its association to the occurrence of PEH in individuais with or without T2D.Furthermore, to the best of our Knowledge, there is only one study that has investigated the effects of exercise (aerobic and / or resistance) on the 24-hour BP response in individuais with T2D. Not to mention that it is not of our knowledge, studies that have investigated the effects of different aerobic exercise intesities on BP 24 hours in subjects with T2D.Additionally, Several studies have investigated the effects of different exercise modes ( e.g., aerobic vs. resistance ), intensities, and durations on BP responses during the post-exercise recovery period. Studies regarding the effects of different sports modalities, especially martial arts, have also been performed, such as: Tai Chi Chuan, Jiu Jitsu, and Judo. However, until now, no study has explored the BP responses after a single Contact Karate…

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Made available in DSpace on 2016-01-04T13:44:51Z (GMT). No. of bitstreams: 2 lauane_gomes_moreno.pdf: 1163569 bytes, checksum: 5bc267921309b4b4da2343951c77a04e (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2014

Funda??o de Amparo ? Pesquisa do estado de Minas Gerais (FAPEMIG)

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq)

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (Capes)

Dado o crescente n?mero de doen?as cr?nicas n?o transmiss?veis (DCNT) que afetam a sa?de e a economia dos pa?ses, alternativas que visem ? diminui??o dos fatores de risco para essas doen?as s?o imprescind?veis. A ado??o de uma dieta equilibrada, que inclua alimentos com potencialidades funcionais, associada ? pr?tica de atividade f?sica regular s?o alternativas atualmente preconizadas. Dentre os alimentos com potencialidades funcionais est? o pequi (Caryocar brasiliense), muito utilizado no Brasil para fins aliment?cios, terap?uticos e cosm?ticos, e que apresenta como componentes majorit?rios lip?deos ricos em ?cidos graxos monoinsaturados, fibras e carotenoides. Estes componentes isoladamente, apresentam alguns efeitos semelhantes ao exerc?cio f?sico aer?bio sobre a redu??o de diversos fatores de risco para DCNT, de forma que associados podem fornecer efeitos potencializadores sobre a redu??o desses fatores de risco. Assim, este estudo teve como objetivo avaliar, em ratos, efeitos biol?gicos advindos da ingest?o da polpa de pequi associada ? pr?tica de exerc?cio f?sico aer?bio regular (EFAR), especificamente sobre vari?veis relacionadas ao crescimento, par?metros cardiovasculares, do metabolismo glic?dico e lip?dico, sobre a histomorfometria duodenal e o estado redox celular. O protocolo experimental consistiu de quatro grupos (n=8) de ratos Wistar machos: CS - animais que receberam ra??o; CT - receberam ra??o e EFAR; PS - receberam ra??o suplementada com polpa de pequi (3,26/100g = +50% do conte?do lip?dico da ra??o) e PT - receberam ra??o suplementada com polpa de pequi e EFAR. O EFAR foi realizado em piscina, em intensidades e cargas progressivas, e a dieta fornecida ad libitum durante quinze semanas. A ingest?o alimentar e o peso corporal foram monitorados durante o per?odo experimental para os c?lculos da ingest?o alimentar e cal?rica, do ganho de peso e dos coeficientes de efici?ncia alimentar (CEA) e energ?tica (CEE). As fezes foram coletadas nas ?ltimas 72 horas do…

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Made available in DSpace on 2016-01-04T13:53:48Z (GMT). No. of bitstreams: 2 lidiane_guedes_oliveira.pdf: 705674 bytes, checksum: 7f2a8cdcec73417a5a58f7784fffca1d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2014

Funda??o de Amparo ? Pesquisa do estado de Minas Gerais (FAPEMIG)

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq)

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (Capes)

Evid?ncias cient?ficas cumulativas sugerem que os ?cidos graxos monoinsaturados (MUFAs) diet?ticos reduzem fatores de risco para o desenvolvimento de desordens metab?licas, as quais causam muitas doen?as cr?nicas n?o transmiss?veis (DCNT), tais como o diabetes n?o insulinodependente e as cardiovasculares. O ?leo de pequi (Caryocar brasiliense) apresenta em sua composi??o predom?nio de ?cidos graxos monoinsaturados e carotenoides antioxidantes, os quais t?m sido tamb?m relacionados ? redu??o do risco para DCNT. Entretanto, ainda s?o escassos na literatura estudos que avaliem efeitos fisiol?gicos do ?leo de pequi dentro da perspectiva de alimento funcional, ou seja, associado ? dieta usual e h?bitos saud?veis de vida, dentre os quais se destaca o exerc?cio f?sico regular. Diante desse contexto, o objetivo deste estudo foi pesquisar a influ?ncia da ingest?o do ?leo de pequi associada ao exerc?cio f?sico aer?bio regular (EFAR), sobre vari?veis relacionadas ao crescimento, ao metabolismo e par?metros cardiovasculares de ratos, desde est?gios iniciais de vida (p?s-desmame) at? o in?cio da vida adulta (20 semanas de vida). O protocolo experimental consistiu de quatro grupos (n=8) de ratos Wistar machos: CS - animais que receberam ra??o; CT - receberam ra??o e EFAR; OS - receberam ra??o suplementada com ?leo de pequi (2,25/100g = +50% do conte?do lip?dico da ra??o) e OT - receberam ra??o suplementada com ?leo de pequi e EFAR. O EFAR foi realizado em piscina, em intensidades e cargas progressivas, e a dieta fornecida ad libitum durante 15 semanas. A ingest?o alimentar e o peso corporal foram monitorados durante o per?odo experimental para os c?lculos da ingest?o alimentar e cal?rica, do ganho de peso, do coeficiente de efici?ncia alimentar (CEA%) e do ?ndice de massa corporal (IMC). A press?o arterial sist?lica (PAS) e a frequ?ncia card?aca (FC) foram aferidas no in?cio e na ?ltima semana do experimento. No ?ltimo dia, os animais foram eutanasiados, as cavidades abdominais e…

Submitted by Nadir Basilio ([email protected]) on 2016-05-25T18:35:39Z No. of bitstreams: 1 Simone Adriana Guaraldo.pdf: 3131023 bytes, checksum: 777ceaa800ff93102e3d158cff3ce1fe (MD5)

Made available in DSpace on 2016-05-25T18:35:39Z (GMT). No. of bitstreams: 1 Simone Adriana Guaraldo.pdf: 3131023 bytes, checksum: 777ceaa800ff93102e3d158cff3ce1fe (MD5) Previous issue date: 2014-12-18

Purpose: The aim of the present study was to determine whether low-level laser therapy (LLLT), when used in conjunction with aerobic training, interferes with the oxidative stress, thereby influencing the performance of old rats participating in swimming. Materials and Methods: A total of 30 Wistar rats (norvergicos albinus) were used for this study: 24 aged rats, and 6 young rats. The older animals were randomly divided into 4 groups designated as follows: Aged-Control, Aged-Exercise, Aged-LLLT, Aged-LLLT/Exercise group and. Young-Control animals. Aerobic capacity (VO2 0.75max) was analyzed after and before the training period. The Aged-Exercise and Aged-LLLT/Exercise groups were trained for 6 weeks. LLLT laser was applied at 808 nm and 4 joules of energy to the indicated groups throughout training. The rats were euthanized, and muscle tissue were collected for analysis the index of lipid peroxidation (TBARs), glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) activity. Results: Statistically significant differences in VO2 0.75max values were observed for the Aged-LLLT/Exercise group compared to the baseline older group (p <0.01) and compared with LLLT and exercise group (p <0.05).. The results indicate that the activity of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) was superior and statistically significant (p <0.05) in the association of LLLT and exercise when compared to the LLLT group and group exercise. Was also observed that young animals presented for the activity of antioxidant enzymes smaller and statistically significant values the Aged group. The LLLT plus exercise and only the LLLT and training (exercise group) was also able to mitigate the concentration of TBARS with (p> 0.05). Conclusion: These results suggest that laser therapy in conjunction with aerobic training may provide a therapeutic approach for reducing oxidative stress, as well as the increase in VO2 0.75max allometric, indicating along with increasing speed media improved performance in aged animals treated with LLLT associated with aerobic training by swimming.

O objetivo do presente estudo foi verificar se a terapia com laser de baixa intensidade, usada em conjunto com o treinamento aer??bio, interfere com o estresse oxidativo, influenciando assim o desempenho de ratos idosos submetidos a um treinamento de nata????o. Materiais e M??todos: Um total de 30 ratos Wistar (norvergicos albinus) foram utilizados para este estudo: 24 ratos idosos, e 6 ratos jovens. Os animais idosos foram divididos aleatoriamente em 4 grupos designados da seguinte forma: Idosos-Controle;…

Submitted by Nadir Basilio ([email protected]) on 2016-05-25T16:04:47Z No. of bitstreams: 1 Nicole Cristine Rigonato de Oliveira.pdf: 1240943 bytes, checksum: 14fa67b6692555f3bc76fb1f34186220 (MD5)

Made available in DSpace on 2016-05-25T16:04:47Z (GMT). No. of bitstreams: 1 Nicole Cristine Rigonato de Oliveira.pdf: 1240943 bytes, checksum: 14fa67b6692555f3bc76fb1f34186220 (MD5) Previous issue date: 2014-12-19

The acute respiratory distress syndrome (ARDS) is a disease characterized by respiratory failure due to an inflammatory response, which has high morbidity and mortality. Several cytokines seem to orchestrate the acute and chronic processes, mainly mediated by toll like receptors (TLRs). The literature demonstrates that aerobic exercise (AE) is capable of decreasing the secretion of pro-inflammatory cytokines in the lungs mediated increased release of interleukin 10 (IL-10), and AE modulate expression of TLRs and antioxidant enzymes. The objective of this study was to evaluate whether the anti-inflammatory effects of AE in an experimental model of intra and extrapulmonary ARDS are mediated by IL-10. For this, the animals were subjected to physical training on a treadmill, moderate for 4 weeks. 24 hours after the last physical test, animals received LPS by intratracheally (it) (10ug / animal) or intraperitoneally (ip) (100ug / animal). After 24 hours, the animals were assessed for the number of cells and pro- and anti-inflammatory cytokines in bronchoalveolar lavage fluid (BAL) and serum were the number of neutrophils in the lung parenchyma and expression of TLR4, TLR7, SOD, ??nion and QL in lung homogenates. AE reduced accumulation of neutrophils in the lung parenchyma, so it LPS and LPS ip (p <0.01) and BAL (p <0.01). AE attenuate the levels of proinflammatory cytokines in BAL and serum (p <0.05), as measured by ELISA. AE had levels of anti-inflammatory cytokine IL-10 increased in the serum and BAL (p <0.05). AE also reduced the expression of TLR4 in lung homogenates (p <0.05) and increased the expression of TLR7 in group LPS + AE evaluated by western blotting (p <0.05). The results for the antioxidant enzyme SOD showed a significant increase in the groups submitted to AE. It follows that the impact of reduced LPS-induced ARDS, regardless of etiology, and these effects appear to be mediated by modulation of the AE secretion of anti-inflammatory cytokines, especially IL-10, modulating TLR4 and TLR7 and increased expression of SOD (p <0.05).

A s??ndrome do desconforto respirat??rio agudo (SDRA) ?? uma doen??a caracterizada pela insufici??ncia respirat??ria decorrente a uma resposta inflamat??ria, que apresenta alta morbi-mortalidade. Diversas citocinas parecem orquestrar os processos agudo e cr??nico, mediados principalmente por receptores toll like (TLRs). A literatura demonstra que o exerc??cio aer??bio (EA) ?? capaz de diminuir a secre????o de citocinas pr??-inflamat??rias nos pulm??es, mediado pelo aumento da libera????o de interleucina 10 (IL-10), al??m de o EA modular a express??o de TLRs e…

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Funda??o de Amparo ? Pesquisa do estado de Minas Gerais (FAPEMIG)

O aumento da preval?ncia da obesidade em todo o mundo ? motivo de grande preocupa??o devido ? forte liga??o com outras doen?as como doen?as cardiovasculares, resist?ncia ? insulina e diabetes tipo 2. A obesidade ? um dos principais contribuintes para a resist?ncia ? insulina e mais de 80% dos indiv?duos com diabetes tipo 2 tamb?m s?o obesos e um n?mero substancial desses pacientes expressa anormalidades na sensibilidade ? insulina e no metabolismo da glicose. O exerc?cio f?sico vem sendo utilizado como um importante recurso terap?utico para o tratamento e preven??o de diversas doen?as decorrentes do excesso de adiposidade. O exerc?cio de subida em escada para roedores pode ser uma estrat?gia de interven??o para se estudar seus efeitos sobre o metabolismo da glicose. Este trabalho teve como objetivo investigar os efeitos de um protocolo de exerc?cio de subida em escada em camundongos Balb/c alimentados com dieta hiperlip?dica sobre par?metros associados ? obesidade e resist?ncia ? insulina. Para isso, 48 animais foram divididos em 2 grupos (n=24) sendo grupo chow alimentado com ra??o comercial (10% das calorias de gordura) e grupo HFD (de high fat diet) alimentado com dieta hiperlip?dica (42% das calorias de gordura) por 12 semanas. Nas quatro primeiras semanas, todos os animais permaneceram sedent?rios alimentados com suas respectivas dietas. Na quinta semana todos os animais foram adaptados para a subida em escada e passaram por testes f?sicos pr?-exerc?cio de 3 repeti??es m?ximas (3RM) e de resist?ncia. Os grupos foram subdivididos em grupos sedent?rios e grupos treinados (n=12/grupo). Na sexta semana experimental se deu o in?cio do exerc?cio que durou por 6 semanas, sendo iniciado com 5 s?ries de 6 subidas e carga de 80% do peso do teste de 3RM, progredindo at? atingir 6 s?ries de 8 subidas e carga correspondente a 110% do 3RM. Os animais dos grupos sedent?rios n?o realizaram o exerc?cio f?sico. Ao final do experimento todos os animais foram submetidos aos testes f?sicos p?s-exerc?cio e testes de toler?ncia ? glicose e ? insulina. Em seguida foram eutanasiados e foram coletados tecidos…

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CAPES

Introdu????o: A Doen??a Hep??tica Gordurosa N??o Alco??lica (DHGNA) ?? uma condi????o cl??nica patol??gica comum em adultos. Embora tenha caracter??sticas histopatol??gicas semelhantes ??s encontradas na hepatite alco??lica, suas causas n??o s??o plenamente conhecidas. Verifica-se que a maioria dos pacientes com DHGNA apresenta aus??ncia de sinais e sintomas e suas formas agravantes aparecem como a principal causa de morbidade e mortalidade ligadas a doen??as hep??ticas. A DHGNA est?? associada ?? obesidade, resist??ncia ?? insulina, ao sedentarismo, e ?? ado????o de h??bitos alimentares inadequados. A preval??ncia de sobrepeso e obesidade vem aumentando significantemente no mundo, sendo considerado um importante problema de sa??de p??blica tanto para pa??ses desenvolvidos como em desenvolvimento. Objetivo: Identificar a preval??ncia e fatores associados ?? DHGNA em moradores da comunidade Madureira de Pinho localizada em um bairro popular de salvador. Casu??stica e m??todos: Foram entrevistados 102 adultos de ambos os sexos, mas ap??s exclus??o dos indiv??duos que apresentavam etilismo significativo, IMC abaixo de 25 Kg/m2 e hist??ria de hepatite, a amostra foi ajustada para 68 indiv??duos, os quais foram submetidos ?? ultrassonografia abdominal superior para identifica????o de presen??a e gradua????o de esteatose hep??tica. Resultados: A preval??ncia de DHGNA foi elevada e 94,9% daqueles que apresentaram a rela????o cintura e quadril > 0,9 mm apresentou diferen??a estatisticamente significante (p=0,01). O nosso estudo registrou ainda que 73,5% dos indiv??duos que n??o referiram hist??rico de exerc??cio f??sico apresentavam DHGNA, sendo estatisticamente significante quando comparada com os participantes que referiram realiza????o de exerc??cio f??sico pr??via (p<0,001). A ingest??o de refrigerante, temperos prontos e alimentos instant??neos n??o correlacionou-se com a presen??a de esteatose hep??tica nesta popula????o Conclus??o: A preval??ncia de DHGNA foi elevada nos participantes, sendo que os ??ndices antropom??tricos e o hist??rico de exerc??cio f??sico foram estatisticamente significantes. No entanto, os h??bitos alimentares n??o foram relacionados com a presen??a de DHGNA. Desse modo, devemos sensibilizar a popula????o em geral para a pr??tica regular de exerc??cio f??sico, com a finalidade de reduzir o risco de desenvolvimento DHGNA e melhorar a qualidade de vida.

Salvador

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Made available in DSpace on 2020-03-24T16:54:50Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) caique_olegario_diniz_magalhaes.pdf: 1012130 bytes, checksum: ae0e46c85ac2287a14f818148b6afec7 (MD5) Previous issue date: 2019

Introdu??o: O uso de decanoato de nandrolona (DN) ? frequentemente utilizado como esteroide anab?lico androg?nico (EAA), em doses suprafisiol?gicas, por atletas e n?o atletas, com fins de melhoria de desempenho esportivo ou est?tico. Recentes estudos t?m mostrados efeitos delet?rios no hipocampo e preju?zo na aprendizagem/mem?ria com o uso de DN. Em contrapartida, muitos estudos t?m mostrado um aumento da plasticidade cerebral em ratos submetidos a treinamento resistido (TR), mas nenhum ainda verificou o uso de DN na aprendizagem/mem?ria associado ao TR. Devido ao fato de ser muito comum o uso do DN, em doses suprafisiol?gicas, por praticantes recreativos de TR e principalmente por atletas amadores e profissionais para acelera??o do desempenho, torna-se fundamental entender como o DN pode interferir nos benef?cios do TR na aprendizagem/mem?ria. Objetivo: avaliar os efeitos do DN associado ao TR, na aprendizagem/mem?ria e neuroplasticidade cerebral de ratos Wistar. Materiais e M?todos: Os animais foram distribu?dos em quatro grupos (N= 12): a) SED/SAL; b) SED/DECA; c) TREIN/SAL; d) TREIN/DECA. O uso do DN foi administrado em dose suprafisiol?gica para simular o uso abusivo que ocorre em humanos. Para isso, a dose administrada nos animais foi de 15mg/Kg ao dia, por 8 semanas (5 dias por semana). O TR foi realizado em escada adaptada e consistiu em 40 dias de treino (8 semanas). Cada sess?o de treino consistiu em 8 s?ries (2x50%, 2x75%, 2x90%, 2x100%) com sobrecarga aplicada depois de um teste de for?a m?xima. Ap?s a interven??o, os animais foram submetidos ao teste de reconhecimento de objetos (NOR). Resultados: Treinamento Resistido, no momento pr? (SEM 1) sem diferen?a entre os grupos. No grupo SED/SAL SEM 1 (279,8?29,95g) e SEM 8 (297,4?29,06g) p>0,05 sem diferen?a. Grupo SED/DECA SEM 1 (264,1?22,47g) e SEM 8 (446,9?19,49g) p<0,05. Grupo TREI/SAL SEM 1 (294,4?31,20g) e SEM 8 (933,3?51,87g) p<0,05. Grupo TREI/DECA SEM 1 (319,2?29,55g) e SEM 8 (1086?95,88g). No momento p?s (SEM 8) diferen?a entre grupo SED/DECA (446,9?19,49g) em rela??o aos grupos TREI/SAL (933,3?51,87g) e TREI/DECA (1086?95,88g) p<0,05. Diferen?a no momento p?s…

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Made available in DSpace on 2016-01-04T17:41:47Z (GMT). No. of bitstreams: 2 silvia_mourao_magalhaes.pdf: 1033681 bytes, checksum: 4abcd5281d35fd4412fc135e71a22dda (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2014

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (Capes)

Este estudo avaliou o efeito agudo e cr?nico do exerc?cio intervalado de alta intensidade sobre o estado redox sangu?neo de homens sedent?rios. Para isso, o estudo foi dividido em duas etapas. Na primeira etapa 17 indiv?duos sedent?rios foram submetidos a uma sess?o de exerc?cio intervalado de alta intensidade (HIIE, do ingl?s high intensity interval exercise), no cicloerg?metro, composta por 8 est?mulos, a 90% da pot?ncia m?xima, intercalados por 75 segundos de recupera??o ativa a 30 watts. Antes e, imediatamente, ap?s o exerc?cio amostras de sangue foram coletadas para a avalia??o da concentra??o de subst?ncias reativas ao ?cido tiobarbit?rico (TBARS) e da capacidade antioxidante total do plasma; e a concentra??o de TBARS e atividade das enzimas antioxidantes super?xido dismutase (SOD) e catalase (CAT), no lisado eritrocit?rio. Agudamente, o HIIE n?o alterou a concentra??o plasm?tica de TBARS, embora a capacidade antioxidante total do plasma tenha sido significativamente menor (p=0,05) imediatamente ap?s o exerc?cio. N?s eritr?citos, a concentra??o de TBARS foi significativamente menor (p=0,03), enquanto a atividade da SOD foi significativamente maior (p=0,04), imediatamente ap?s o exerc?cio. Na segunda etapa 9 indiv?duos, que participaram do HIIE, foram submetidos a um programa de treinamento intervalado de alta intensidade (HIIT, do ingl?s high intensity interval training), 3 vezes por semana, durante 4 semanas (12 sess?es de treinamento). Par?metros do estado redox foram avaliados antes e ao final do treinamento. O HIIT aumentou (p=0,05) a capacidade antioxidante total do plasma, e, nos eritr?citos, a concentra??o de TBARS foi menor (p=0,03) e a atividade da catalase foi maior (p=0,04) ap?s o treinamento. As modifica??es do estado redox sangu?neo alcan?adas em curto prazo com o programa de HIIT utilizado neste estudo podem ser consideradas uma resposta ben?fica adicional para a esta modalidade de treinamento, e neste contexto o HIIT pode ter um papel terap?utico nas condi??es cl?nicas decorrentes ou associados a um quadro de desequil?brio redox.

Disserta??o (Mestrado) ? Programa Multic?ntrico de…

p. 1-45

Submitted by Antonio Geraldo Couto Barreto ([email protected]) on 2013-10-08T13:26:14Z No. of bitstreams: 1 Mansueto Gomes Neto - FINAL (22-08-2013).pdf: 5652589 bytes, checksum: ff26c998fb77a3514c2b46981f3d0c09 (MD5)

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A terapia antirretroviral potente (TARV) tem sido associada a uma variedade de efeitos adversos, o que aumenta a incid??ncia de dist??rbios funcionais, o risco de eventos cardiovasculares e diminui a qualidade de vida (QV) em pacientes com HIV. A identifica????o dos riscos cardiovasculares (RCV) e as limita????es funcionais podem contribuir na elabora????o de estrat??gias de preven????o e reabilita????o de pacientes com HIV. Assim, o objetivo desta tese foi identificar os RCV em pacientes com HIV/AIDS e avaliar os efeitos de programas estruturados de exerc??cios f??sicos na condi????o cardiovascular, funcional e QV, atrav??s de revis??o sistem??tica da literatura. As bases de dados consultadas foram: Medline, Scielo, Lilacs, e PEDro. Foram selecionados estudos que identificassem RCV em pacientes em uso de TARV e ensaios cl??nicos randomizados (ECRs) que avaliaram o efeito do exerc??cio resistido (ER), exerc??cio aer??bico (EA) e o treino concorrente, nos desfechos composi????o corporal, desempenho muscular, capacidade funcional aer??bica e QV. A escala PEDro foi utilizada para avalia????o da qualidade dos ECRs. Em rela????o ao RCV em pacientes com HIV em uso de TARV, a revis??o sugere um excesso de RCV quando comparado a pessoas n??o infectadas. A utiliza????o da TARV foi associada com aumento nos n??veis de colesterol, triglicer??deos, acumulo de gordura visceral e disfun????o endotelial. Alguns regimes TARV aumentam risco de dislipidemia, doen??a cardiovascular, particularmente regimes contendo inibidores de protease. ECRs individuais sugerem que cada tipo de exerc??cio contribui na melhora de diferentes par??metros fisiol??gicos e funcionais. O ER foi associado com melhora significativa nos desfechos de composi????o corporal e desempenho muscular, o EA foi identificado por favorecer a melhora tanto da composi????o corporal quanto da capacidade aer??bica e o treino concorrente foi o que apresentou resultados significativos em todos os desfechos avaliados, devendo ser a modalidade de escolha na indica????o do exerc??cio terap??utico em pacientes com HIV.

Salvador

Submitted by ROBERTO PAULO CORREIA DE ARA??JO ([email protected]) on 2016-10-19T15:01:34Z No. of bitstreams: 1 Vanessa De Nardi.pdf: 1429006 bytes, checksum: 2370a16f052c0eb092fd1a8c3f8b5798 (MD5)

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O fonoaudi??logo ?? um profissional da ??rea de sa??de, respons??vel por a????es individuais e coletivas que visam ?? promo????o, preven????o e recupera????o da sa??de fonoaudiol??gica da popula????o, tendo interesse nos dist??rbios que afetam um grupo espec??fico, mas aplicando medidas de car??ter comunit??rio. Que devem demonstrar a atua????o interdisciplinar da ci??ncia fonoaudiol??gica, condi????o profissional relevante na manuten????o da sa??de e da qualidade de vida, uma vez que a comunica????o permeia todas as rela????es humanas, propicia a participa????o social, a aprendizagem e contribui para a integridade emocional. Objetivo: Descrever o perfil do ensino em sa??de coletiva na forma????o do profissional de Fonoaudiologia nas Institui????es de Ensino Superior no Estado da Bahia. Metodologia: A presente pesquisa teve car??ter observacional, descritiva e anal??tica, com abordagem quantitativa/ qualitativa, atrav??s da qual foi estudado o universo de coordenadores e docentes dos cursos de gradua????o instalados no estado da Bahia que ministram aula de sa??de coletiva ou p??blica, mediante a aplica????o de question??rios. Resultados: As coordenadoras e as docentes tiveram uma gradua????o especifista, com escasso conhecimento sobre sa??de coletiva e p??blica, buscando o conhecimento depois em especializa????es ou outros cursos. Conclus??es: As Institui????es de Ensino Superior tem o papel de formadoras de profissionais, prestadoras de servi??o comunit??rio, entre outros. As coordenadoras e docentes est??o envolvidas com as diretrizes curriculares, para aprimorar os projetos pedag??gicos dos cursos.

Submitted by Sara Ribeiro ([email protected]) on 2017-04-06T13:41:06Z No. of bitstreams: 1 CintiaMota CardealTese2014.pdf: 2995266 bytes, checksum: 4704c3b2f9fabf12e53e2d59ca4d1e83 (MD5)

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This study aimed to analyze the profile of executive function and neuroelectrical activations answers from the P300 component of school under acute stimuli of exercise at different intensities . The sample consisted of 60 individuals , divided randomly into control group , experimental group to the experimental group and moderate exercise to intense exercise aged 7 to 14 years . Initial tests to characterize the sample and spirometry for verification and determination of VO2max values for exercise intensity were applied . And the second time were applied cognitive tests ( Flanker and oddball paradigm ) moderate or intense physical exercise , with the reapplication of cognitive tests after acute exercise . It was observed that held moderate and intense aerobic exercise differ statistically from the control group in the executive function testing and procurement of P300. In testing the intense attention the only group differed significantly from the control group mind. In both tests the intensive group achieved better results compared to the other groups. The neuroelectrical frontoparietal network was established for the Flanker paradigm and frontoparietal network and the temporal to the oddball paradigm. We conclude that the results point to a favorable direction of physical activity in the school of moderate and intense in general.

Essa pesquisa teve como objetivo analisar o perfil das respostas da fun????o executiva e as ativa????es neuroel??tricas a partir do componente P300 de escolares sob est??mulos agudos de exerc??cio f??sico em diferentes intensidades. A amostra foi constitu??da de 60 indiv??duos, divididos de forma aleat??ria em grupo controle, grupo experimental para o exerc??cio moderado e grupo experimental para o exerc??cio intenso com idade entre 7 e 14 anos. Foram aplicados os testes iniciais para caracteriza????o da amostra e a ergoespirometria para a verifica????o do VO2max e determina????o dos valores para intensidade do exerc??cio. E no segundo momento aplicaram-se os testes cognitivos (paradigma Flanker e oddball) o exerc??cio f??sico moderado ou intenso, havendo a reaplica????o dos testes cognitivos logo ap??s o exerc??cio agudo. Foi observado que realizou o exerc??cio aer??bio moderado e intenso se diferenciaram estatisticamente do grupo controle no teste de fun????o executiva e nas aquisi????es do P300. No teste aten????o o somente o grupo intenso se diferenciou significativa mente do grupo controle. Em ambos os testes o grupo intenso obteve melhores resultados em rela????o aos demais grupos. A rede neuroel??trica frontoparietal foi estabelecida para o paradigma Flanker e a rede frontoparietal e…

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Made available in DSpace on 2019-05-29T14:08:40Z (GMT). No. of bitstreams: 1 Patricia_Alcantara_Tese (final).pdf: 6880482 bytes, checksum: a7e10ffe76705ad59ecc5c562d472695 (MD5) Previous issue date: 2018-11-26

Fundamento: A mobilidade ?? um fator fundamental para a recupera????o funcional dos pacientes ap??s a cirurgia card??aca. Com o objetivo de promover o retorno mais r??pido para as atividades laborais e sociais do paciente e reduzir o per??odo de interna????o tem-se estimulado precocemente a mobiliza????o e a sa??da do leito. No entando, a compreens??o sobre os fatores que influenciam nessa mobilidade e a comprova????o de interven????es que implementem o desempenho f??sico logo ap??s o procedimento operat??rio ainda s??o escassas. Objetivos: objetivo (1) explorar a hip??tese de que a utiliza????o de cicloerg??metro na fisioterapia incrementa o desempenho f??sico de pacientes submetidos a cirurgia card??aca, durante a mobiliza????o precoce em UTI; objetivo (2) descrever a resposta hemodin??mica ao estresse gravitacional em pacientes submetidos a cirugia card??aca; objetivo (3) identificar potenciais determinantes de recupera????o da mobilidade f??sica em pacientes submetidos a cirugia card??aca. M??todos: Objetivo (1) ensaio cl??nico randomizado envolvendo pacientes submetidos a cirurgia card??aca valvar e/ou revasculariza????o mioc??rdica no per??odo de junho a dezembro de 2016. Foram exclu??dos pacientes em ventila????o mec??nica acima de 12h, com Hb ???8 mg/dl ou com instabilidade hemodin??mica. Ap??s a cirurgia, os pacientes foram randomizados em dois grupos: grupo cicloerg??metro e grupo controle. Ambos os grupos foram envolvidos na an??lise da resposta incremental do cicloerg??metro, onde o mesmo foi empregado, sem imposi????o de carga, em membros superiores e inferiores, enquanto os pacientes permaneciam na unidade de terapia intensiva (UTI). O desempenho f??sico foi avaliado pela velocidade de marcha, obtida ap??s a alta da UTI, mensurada por um avaliador cego. Objetivos (2 e 3) para atender os objetivos descritivos de identificar os determinantes da mobilidade (atrav??s do n??mero de passos) e da resposta hemodin??mica ao estresse gravitacional foram analisadas as respostas dos pacientes do grupo controle, onde foi aplicado o tratamento usual (exerc??cio ativo assistido). Em se considerando este um estudo explorat??rio e preliminar, como forma de otimizar a potencial gera????o de hip??tese para efic??cia, optou-se pela an??lise por protocolo, excluindo os pacientes que n??o completaram os exerc??cios. Resultados: duzentos e doze pacientes foram randomizados,…

Submitted by PPG Servi?o Social ([email protected]) on 2018-09-26T12:41:27Z No. of bitstreams: 1 Disserta??o - G?ssica Cristina Ozelame.pdf: 1455601 bytes, checksum: 7de5304166eb0ddeb5fb9734ad0bf502 (MD5)

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Made available in DSpace on 2018-09-28T13:11:30Z (GMT). No. of bitstreams: 1 Disserta??o - G?ssica Cristina Ozelame.pdf: 1455601 bytes, checksum: 7de5304166eb0ddeb5fb9734ad0bf502 (MD5) Previous issue date: 2018-05-29

Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES

The present study deals with the advisory and consulting processes, discussing the teaching and the professional practice of social workers, considering that these processes are private assignments and professional competences, however, they are spaces little occupied by the professional category, in which the production of the knowledge manifests itself in an incipient way. Aiming to answer how the advisory and consulting processes are being operationalized in the training and professional practice of social workers in Rio Grande do Sul, the objective was to analyze the aspects related to the training and professional practice of social workers in the advisory and discussing challenges and possibilities. This is a qualitative study, guided by the dialectical-critical method, based on documental, bibliographical and empirical research, totalizing a sample of twenty-three (23) documents for documentary research, thirty-two (32) research productions and twenty-five (25) subjects participating in the empirical research (coordinators, teachers and students of the Bachelor's degree in Social Work). For the treatment and analysis of the data, the content analysis based on Pag?s (2006) was used. It is concluded that there are contradictions in the recognition of the importance of teaching the advisory and consulting processes now being denied, sometimes being placed in the background, during training, as well as in the way in which it is being addressed by UFAS. This reality reflects and may explain the incipient manifestation of professional practice in these processes. From the data, it is pointed out the importance of the work of social workers in these processes, and the subjects surveyed stressed the need for Social Work to reorganize itself to expand its work in these spaces, to strengthen the formation process and the materialization of the ethical- political, since these processes are in line with it. Finally, propositions are presented to contribute to overcoming the limits and materialization of the possibilities of acting in these processes.

O presente estudo aborda os processos de assessoria e consultoria, debatendo o ensino e o exerc?cio profissional dos assistentes sociais, considerando que estes…

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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES

Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq

INTRODUCTION: Potential threats to homeostasis may occur during the in utero period, promoting programming effects on both neurological development and hypothalamic-pituitary-adrenal (HPA) axis function. The HPA axis acts as a control and regulatory center of the body that connects the central nervous system to the hormonal system. The axis responds to the stressor stimulus and assists the body to maintain homeostasis, as well as being essential to the normal regulatory physiological functioning. Physically fit and physically active individuals exhibit a lower rate of health problems, especially when faced with stressful situations, contributing to reduced levels of anxiety and depression. OBJECTIVE: To evaluate the effects of physical exercise before the gestational period on changes due to prenatal stress in adult mice. METHODS: Balb/c female and male mice were divided into three groups: control (CTLE), prenatal restraint stress (PNS) and physical exercise before the gestational period and prenatal restraint stress (EX+PNS). The weight of the animals was evaluated during gestation, days 1, 10 and 21 of life and also as adults. Animals were then maintained until adulthood (60 days of life) when fear/anxiety behaviors were evaluated in the elevated plus maze, and depression was evaluated using the preference for sucrose and the ingestion of sucrose test. In addition, real-time PCR gene expression of corticotrophin releasing hormone (CRHR1) type 1 receptor in the prefrontal cortex, glucocorticoid receptor (GR) and mineralocorticoid (MR) receptor in the hippocampus, as well as plasmatic concentrations of corticosterone were evaluated. RESULTS: During gestation, females of the EX+PNS group presented greater weight in relation to the CTLE group. Regarding the offspring weight, animals of the EX+PNS group showed an increase in weight on days 1, 10 and 21 of life, compared to the PNS group. During the adult life, animals stressed in the prenatal period presented lower weight, while the pregestational exercise promoted an increase in the offspring weight in relation to the CTLE group. In relation to behavioral tests, there was a significant decrease in the time spent in the open arms of the elevated plus maze in the PNS and EX+PNS groups, in both…

Submitted by PPG Pediatria e Sa?de da Crian?a ([email protected]) on 2019-06-21T19:29:20Z No. of bitstreams: 1 Disserta??o Nati 28052019.pdf: 2043920 bytes, checksum: 871ac8fc2e8cb3ca1205aa3f994b34c6 (MD5)

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Made available in DSpace on 2019-06-27T16:59:51Z (GMT). No. of bitstreams: 1 Disserta??o Nati 28052019.pdf: 2043920 bytes, checksum: 871ac8fc2e8cb3ca1205aa3f994b34c6 (MD5) Previous issue date: 2019-03-01

Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq

Introduction: Cystic fibrosis (CF) is a genetic disease that affects several systems and organs and requires a regular and complex treatment. Physical exercise is recommended as an important part of the treatment. However, the low adherence of patients to this recommendation is already known, which may influence quality of life survival. In order to improve adherence to exercise, the use of interactive video games (VG) may emerge as an important tool. Objective: To assess whether the use of VG by CF and healthy individuals generates the cardiorespiratory demand necessary for aerobic physical training, using as a parameter the performance in the cardiopulmonary exercise test (CPET). Methods: Cross-sectional study with CF and healthy subjects (control group - CON), matched by age and gender, aged over 6 years old. Subjects who were unable to perform CPET were excluded. The study was divided into 2 visits: on the first visit, anthropometric measures, spirometry, and CPET were performed for both groups. In addition, during this visit, a respiratory health questionnaire was applied to the CON group. On the second visit, a physical activity questionnaire (IPAQ-A/IPAQ-C) was applied and the VG tests were performed using Nintendo Wii (Wii Fit Plus: (1) Obstacle Course, (2) Rhythm Boxing, and (3) Free Run) and Xbox One (Just Dance 2015: (1) Love Me Again, (2) Summer and (3) Happy), 10 minutes for each console. During both CPET and the use of VG, a gas analyzer was used to measure cardiorespiratory variables. In addition, during VG use, an accelerometer (wGT3X-BT) was used and the degree of physical effort and satisfaction was quantified. Descriptive statistics, Student's t-test and one-way ANOVA (with Bonferroni post hoc test) were used. The study was approved by the Research Ethics Committee. Results: Twenty-five subjects were recruited for the CON and 30 for the CF group, with a mean age of 16.2?5.0 and 16.9?5.1, respectively. The mean (%) FEV1 in the CF group was 73.3?24 and the FVC was 81.2?19.6, which represents lower values (p<0.05) compared to the CON group. Regarding the level of physical activity, there were no differences between groups (p>0.05). There were also no differences between groups at peak exercise (CPET) for heart rate (HR) (186.0?9.0 vs 180.0?12.6 bpm), VO2 (36.7?8.50 vs…

Submitted by Francisco Costa ([email protected]) on 2013-07-03T16:59:42Z No. of bitstreams: 1 Tese de Doutorado.pdf: 8524731 bytes, checksum: a775236b9a52729aecc385b07076ae71 (MD5)

Approved for entry into archive by Eleonora Guimaraes([email protected]) on 2013-07-03T20:50:25Z (GMT) No. of bitstreams: 1 Tese de Doutorado.pdf: 8524731 bytes, checksum: a775236b9a52729aecc385b07076ae71 (MD5)

Made available in DSpace on 2013-07-03T20:50:25Z (GMT). No. of bitstreams: 1 Tese de Doutorado.pdf: 8524731 bytes, checksum: a775236b9a52729aecc385b07076ae71 (MD5)

Esta tese analisa em profundidade o sistema institu??do pelo governo federal em 1933 para controlar a pr??tica profissional da arquitetura no Brasil ??? o Confea/Crea ??? bem como fatores hist??ricos que levaram ?? sua cria????o, como o progressivo surgimento de sistemas similares em outros pa??ses, e a evolu????o de tal pr??tica e dos modos de treinar os projetistas arquitet??nicos. Ao Confea/Crea deu-se compet??ncia para fiscalizar tamb??m a pr??tica profissional de engenheiros que n??o eram projetistas arquitet??nicos, como os engenheiros mec??nicos e el??tricos, e com o passar do tempo isto gerou insatisfa????o entre os arquitetos, o que suscitou neles o desejo de deixar o Confea/Crea multiprofissional e formar seu pr??prio sistema regulador, congregando apenas os arquitetos. O foco da tese est?? no per??odo compreendido entre 1933 e 2007 (ano em que ocorreu a ??ltima tentativa malograda dos arquitetos de criar seu pr??prio conselho profissional), mas a an??lise hist??rica que ela apresenta inicia-se com fatos pertencentes ?? era renascentista.

Salvador

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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (Capes)

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq)

A hipertens?o arterial sist?mica essencial parece estar associada com hipertonia simp?tica dependente da atividade colin?rgica central. Dessa forma, hipertensos poderiam apresentar respostas de dissipa??o de calor aprimoradas, especialmente durante a recupera??o do exerc?cio f?sico moderado realizado sob condi??o de estresse t?rmico. Diante disso, o objetivo do estudo foi avaliar as respostas termorregulat?rias de sujeitos hipertensos durante e na recupera??o de exerc?cio f?sico de intensidade moderada realizado em ambiente quente. Para tanto, oito hipertensos essenciais (H) e oito normotensos (N) (idade: 46,5?1,3 e 45,6?1,4 anos; ?ndice de massa corporal: 25,8?0,8 e 25,6?0,6 kg/m2; press?o arterial m?dia: 98,0?2,8 e 86,0?2,3 mmHg, respectivamente) permaneceram na c?mara ambiental (38?C e 60% umidade relativa do ar) durante 2h e 30 minutos (30 minutos em repouso, 1h de exerc?cio na esteira (50% VO2pico) e 1h em recupera??o do exerc?cio). Temperaturas da pele e corporal interna, frequ?ncia card?aca e press?o arterial foram mensuradas. C?lculos de produ??o de calor, taxa de ac?mulo de calor, temperatura corporal, troca de calor por radia??o, convec??o, e atrav?s do trato respirat?rio e suor evaporado foram realizados a partir das vari?veis coletadas. Como resultados, a press?o arterial m?dia dos hipertensos foi maior do que dos normotensos durante todo o protocolo experimental (p < 0,05). Apesar dos par?metros termorregulat?rios avaliados n?o terem sido diferentes entre grupos hipertensos e normotensos em repouso e durante o exerc?cio f?sico no calor, os hipertensos apresentaram menor quantidade de calor acumulado (H: -24,23 ? 3,39 W/m?, N: -13,63 ? 2,24 W/m?, p = 0,03), maior varia??o na temperatura corporal (H: -0,62 ?…

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INTRODU????O: A alta preval??ncia da S??ndrome Metab??lica ?? muito preocupante, j?? que esta s??ndrome ?? preditiva de doen??as cardiovasculares e ??bito. A atividade f??sica tem sido sistematicamente estudada como tratamento desta enfermidade e o m??todo Pilates pode ser uma alternativa, por ser capaz de adaptar-se ??s especificidades biol??gicas de cada indiv??duo. OBJETIVO: Avaliar o efeito da interven????o de dois m??todos de exerc??cios: Pilates vs Esteira nos componentes da s??ndrome metab??lica em mulheres de 40 ?? 70 anos. M??TODO: Trata-se de um estudo piloto com medidas pr?? e p??s-tratamento, com um grupo de compara????o. Quarenta e quatro mulheres volunt??rias, com idade entre 45 e 70 anos, diagnosticadas com s??ndrome metab??lica, foram pareadas por idade e randomizadas, formando o Grupo Pilates (GP n=22) e o Grupo Esteira (GE n=22). Foram submetidas a um per??odo de interven????o de 16 semanas, sendo duas sess??es de Pilates por semana para o GP e duas sess??es de esteira por semana para o GE, todas as sess??es duraram 50 minutos cada, com intensidade do treinamento entre 60% e 70% da frequ??ncia card??aca m??xima. Conclu??ram a interven????o 36 mulheres com dados completos para a reavalia????o, sendo GP (n=18) e o GE (n=18). A an??lise estat??stica utilizada foi baseada em testes n??o param??tricos; foram comparadas as diferen??as antes e ap??s a fase experimental pelos teste de Wilcoxon e Mann Whitney. Para verificar a normalidade entre as vari??veis foi utilizado o teste Kolmogorov-Smirnov. Os dados foram analisados pelo programa SPSS, vers??o 17.0; diferen??as foram consideradas significantes quando a probabilidade de ocorr??ncia foram inferiores a 5%. RESULTADOS: O GP foi semelhante ou GE nas vari??veis significativamente associadas ao melhor desfecho ap??s o experimento, exceto no HDL-c, sendo: ??ndice de Massa Corp??rea GP (p=0,01) GE(p=0,03); Circunfer??ncia da Cintura GP(p=0,01), GE(p=0,01); Press??o Arterial Sist??lica GP (p=0,01) GE(p=0,04); Press??o Arterial Diast??lica GP(p=0,01) GE(p=0,01); Insulina GP(p=0,03) GE(p=0,01); Lipoprote??na de Alta Densidade Colesterol GP(p=0,79) GE(0,01) ; Triglicer??deos GP(p=0,16) GE(p=0,81); Glicemia em Jejum GP(0,15) GE(p=0,86); HOMA-RI GP(p=0,05) GE(p=0,10). Nas vari??veis relacionadas ?? qualidade de vida o GP mostrou-se mais eficiente em rela????o ao GE, sendo: Capacidade Funcional GP(p=0,01) GE(p=0,26); Limita????es por Aspectos F??sicos GP(p=0,01) GE(p=0,02); Dor GP(p=0,01) GE(p=0,53) Estado Geral de Sa??de GP(p=0,03) GE(p=0,06); Aspectos Sociais GP(p=0,06) GE(p=0,03);Vitalidade GP(p=0,01) GE(p=0,87); Limita????o por Aspectos Emocionais GP(0,13) GE(1,00); Sa??de Mental GP(p=0,02)…

Submitted by Nadir Basilio ([email protected]) on 2016-05-25T17:51:42Z No. of bitstreams: 1 Ricardo Wesley Alberca Custodio.pdf: 1719201 bytes, checksum: dde8d630cb7ae3e178cab55eaac0dd13 (MD5)

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Leukotrienes (LTs) play a central role in the pathophysiology of asthma. Aerobic exercise has been shown to be capable of reducing asthmatic inflammation. Therefore, this study investigated whether the anti-inflammatory effects of aerobic exercise are due to inhibition of the pathway of LTs. Forty BALB / c mice were divided into four groups: Control, Exercise, OVA and OVA + Exercise. The mice were sensitized and challenged with ovalbumin. Aerobic training was performed on a adapted treadmill, at low intensity, 5x / week, 1h / session for 4 weeks, after the establishment of airway inflammation. Total and differential cells were analized in bronchoalveolar lavage (BAL), cytokine levels in BAL, the number of lymphocytes and macrophages in the airway wall, the airway remodeling (collagen and elastic fibers, mucous production and thickness of bronchial smooth muscle), bronchial hyperresponsiveness, beyond the levels of leukotriene B4 (LTB4) and leukotriene C4 (LTC4) in BAL. In addition, immunohistochemistry was performed for 5-lipoxygenase (5-LO) LTA4 hydrolase (LTA4H) CysLT1 receptor, CysLT2 receptor, LTC4 synthase, LTB4 receptor 2 (BLT2). The results demonstrated that aerobic exercise reduced the total number of cells (p <0.05), eosinophils (p <0.05), neutrophils (p <0.001), lymphocytes (p <0.001) and macrophage (p <0.01) in BAL and the number of lymphocytes (p <0.05) and macrophages (p <0.01) in the airway wall. In addition, the accumulation of collagen fibers (p <0.01), elastic fibers (p <0.01) and mucus production (p <0.01) and the thickness of bronchial smooth muscle (P <0.05) and bronchial hyperresponsiveness levels at 25 MCh (p <0.05) and 50 MCh (p <0.01) were reduced in mice sensitized and trained. Furthermore, BAL IL-5 (p <0.05) were reduced, and the levels of LTB4 (p <0.05). The expression of 5-LO (p <0.05) LTA4H (p <0.05), the CysLT 1 receptor (p <0.05), CysLT 2 receptor (p <0.05), LTC4 synthase (p <0.05) and BLT2 (p <0.05) in peribronchial leukocytes were reduced by exercise and expression of 5-LO (p <0.05) LTA4H (p <0.05), the CysLT 1 receptor (p <0.05), CysLT 2 receptor (p <0.05), LTC4 synthase (p <0.05) and BLT2 (p <0.05) in the bronchial epithelium. We conclude that the low intensity aerobic exercise reduces phenotype of asthma by inhibiting the leukotriene pathway.

Os leucotrienos (LTs) desempenham um papel central na fisiopatologia da asma. O exerc??cio f??sico aer??bico tem demonstrado ser capaz de reduzir a inflama????o asm??tica. Portanto, este estudo investigou se os efeitos anti-inflamat??rios do exerc??cio aer??bico ocorrem devido ?? inibi????o da via dos LTs. Quarenta camundongos…

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In recent decades it has seen considerable increase in the proportion of elderly people in Brazil. The main causes of mortality in the elderly are cardiovascular and respiratory diseases in 2006 these accounted for respectively 38% and 13% of causes of death in elderly Brazilians. Cardiac surgeries are responsible for high mortality rates. Patients undergoing coronary artery bypass graft surgery (CABG) at high risk of developing pulmonary complications such as atelectasis, pneumonia and pleural effusion. These complications increase the hospital stay and the need for financial resources. After CABG physiotherapist is required to perform Cardiopulmonary and Metabolic Rehabilitation program (CPMR), whose main goal is to help the patient return ace their social and professional activities in the best possible physical condition. Generally CPMR phase I includes stretching, breathing and aerobic exercise by hiking in hospital corridors and training ladder. The bicycle ergometer is a device that has frequently been used by physiotherapists, for the realization thereof does not require the patient support its own weight during training, and also the workload that can be easily adjusted according to each fitness individual. Thus, the objective of this study was to evaluate pulmonary function and the anxiety state of the CABG subjects after undergoing phase I rehabilitation using the cycle ergometer. For this, we performed a randomized, blinded to the evaluator, with patients from 50 years of age, undergoing CABG at the Hospital S?o Lucas. For this, the individuals who agreed to participate were randomly divided into two phase I rehabilitation groups: control group or cycle ergometer group. The control group patients underwent conventional physiotherapy, as the physiotherapy service protocol of the Hospital S?o Lucas. The patients in the intervention group underwent the same protocol of chest physiotherapy, however, the physical therapy was replaced by the use of a cycle ergometer. They were evaluated in the preoperative period and after rehabilitation phase I, the following respiratory parameters: peak expiratory flow, forced expiratory volume in one second, inspiratory and expiratory pressure. Still, the state of anxiety was assessed. The study included 19 patients, and 9 in the control group and 10 in the intervention group. In intra-group comparisons, a significant reduction was observed in maximal expiratory pressure and forced expiratory volume in one second in the control group. A significant reduction in forced expiratory volume in one second in the intervention group was also observed. In intergroup…

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Objective : To assess the impact of a rehabilitation protocol on the functional capacity of patients who underwent coronary artery bypass graft surgery (CABG), after phase I of rehabilitation, using the cycle ergometer.Method : this is a randomized clinical trial blinded to the evaluator. All patients, older than 50 years old, who underwent CABG and did not meet the exclusion criteria, were invited to participate in the study. After signing the Informed Consent (IC), and being submitted to the surgical procedure, participants were included and randomized to rehabilitation in the control group, with the standard protocol, or in the intervention group, keeping breathing exercises from the standard protocol and replacing the usual physical therapy for 20 minutes of activity in cycle ergometer. Functional assessment was performed at the pre-operative period and on the sixth day after surgery, in order to evaluate balance through the unipodal stance test, mobility through the TUG test and aerobic power assessed by the 6MWT.Results : 19 patients were randomized, being 9 individuals allocated to the intervention group and 10 to the control group. Mean age of the participants in the intervention group was similar to the control group (60.8 ? 4.7 vs 62.4 ? 8.1). There was a predominance of man in both groups (55.6% vs 80.0%). In the intragroup comparisons, individuals from the control group showed a significant decrease in the distance walked in the 6MWT. There was no significant difference between groups considering the other functional variables.Conclusion : Using cycle ergometer in cardiac rehabilitation phase I resulted in similar outcomes considering functional assessment; however, the cycle ergometer allowed better monitoring of hemodynamic and respiratory parameters; therefore, it can be an alternative for rehabilitation of CABG phase I.

Objetivo : Verificar o impacto de um protocolo de reabilita??o sobre a capacidade funcional de indiv?duos submetidos a cirurgia de revasculariza??o do mioc?rdio ap?s a fase I de reabilita??o com o uso do cicloerg?metro.M?todo : Trata-se de um ensaio cl?nico randomizado cegado para o avaliador. Todos pacientes acima de 50 anos que realizaram Cirurgia de Revasculariza??o do Mioc?rdio (CRM) e n?o entravam nos crit?rios de exclus?o eram convidados a participar do estudo, ap?s assinarem o Termo de Consentimento Livre e Esclarecido (TCLE) e ter realizado a cirurgia eram inclu?dos e randomizados para a reabilita??o no grupo controle com protocolo j? utilizado pelo hospital ou no grupo interven??o que mantinha os exerc?cios respirat?rios e substitu?a os exerc?cios de…

Com o avan??o da idade, v??rias altera????es funcionais relacionadas com o envelhecimento atingem a sa??de e qualidade de vida do idoso. Elas s??o evidenciadas no sistema cardiovascular, que se torna bastante comprometido devido, principalmente, ?? diminui????o do metabolismo celular, o que leva ao aparecimento de doen??as cardiovasculares, sendo essa a causa de maior morbidade e mortalidade entre os idosos. A avalia????o das respostas globais e integradas dos sistemas envolvidos durante a atividade f??sica do idoso ?? importante e pode permitir a implanta????o de alternativas de interven????o. Este estudo teve por objetivo principal verificar o impacto de um programa exerc??cios em TRX?? - Treino em suspens??o, na aptid??o f??sica e sobre alguns fatores de risco de desenvolvimento de doen??a cardiovascular, em particular sobre as componentes morfol??gicas (IMC, peso, per??metro da cintura, percentagem de massa gorda e massa magra), as componentes funcionais (pot??ncia e resist??ncia aer??bia e for??a dos membros superiores e inferiores) e as componentes biol??gicas (par??metros bioqu??micos, press??o arterial e frequ??ncia card??aca de repouso) em idosos. A nossa amostra foi constitu??da por 2 idosos, um do g??nero feminino e um do g??nero masculino, com idades de 67 e de 70 anos respetivamente. O programa de exerc??cios teve a dura????o de 12 semanas, com 3 sess??es de treino semanais englobando um programa de 12 exerc??cios em TRX?? - Treino em suspens??o, atrav??s de treino em circuito com incremento da intensidade ao longo das sess??es. Relativamente aos resultados, o nosso estudo demonstrou que a realiza????o de um programa exerc??cios em TRX?? - Treino em suspens??o, com a dura????o de 12 semanas, induziu benef??cios ao n??vel de todas as componentes avaliadas confirmando na globalidade a sua efic??cia na preven????o das doen??as cardiovasculares, pelo menos nestes idosos. Palavras-chave:

With advancing age, several functional changes related to aging affect the health and quality of life. This factors are evidenced in the cardiovascular system, which becomes very compromised due, mainly, to the decrease of cellular metabolism, which leads to the appearance of cardiovascular diseases. Therefore, they have a major impact on morbidity and mortality among aged people. In this specific population, the evaluation of the global and integrated responses of the systems involved during physical activity are an important outcome, and may allow the implementation of alternative intervention. The main objective of this study was to attest the impact of an exercise program on TRX?? Suspension Training, on physical fitness and associated risk factors for cardiovascular disease development, in particular on anthropometrics (BMI, weight, waist circumference, fat mass and lean mass), physical function (power and aerobic endurance and upper and lower limb strength) and biological components (biological markers, blood pressure and resting heart rate) in elderly. This case study, involve 2 elderly, one male and one female,…

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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES

LANGONI, Chandra da Silveira. Effects of a group physical activity program in older adults with mild cognitive impairment in the Family Health Strategy of Porto Alegre. 2018. 158f. Thesis (PhD in Biomedical Gerontology) ? School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil, 2018. Mild cognitive impairment (MCI) presents high conversion rates to dementia, a disease of high prevalence in the elderly. The search for measures that prevent or delay this progression is necessary, such as physical exercise. However, randomized and controlled studies that determine the effects of physical exercises are still scarce. Therefore, in the present thesis, two original articles are presented, which describe the findings from a single blind, randomized and matched-pair controlled trial (sex, age, body mass index and Addenbrooke Cognitive Examination score). The sample consisted of 52 sedentary older adults with MCI, Family Health Strategy / Primary Health Care users from Porto Alegre/RS (Brazil), who were randomized into intervention group (IG) and control group (CG). For 24 weeks, the IG participated in two weekly meetings (60 minutes each) of aerobic and muscular strength exercises in group, while the CG maintained its usual routine. The instruments applied before and after the intervention were: Mini Mental State Examination (MMSE); 2-minute stationary walk test (SW); 30-second sit/stand test; functional reach test (FRT); Berg Balance Scale (BBS); Time Up and Go Test (TUG); Geriatric Depression Scale-15 (GDS-15). Prior to the intervention, the IG and CG did not differ statistically in any of the analyzed variables. In the first article, the effects of the exercise program on the cognitive function, conditioning, strength and balance of the participants were determined. In the intra-group analysis, the IG showed a significant increase in the mean MMSE scores (21.9?4.8x25.0?4.7), sit/stand repetitions (9.3?2.0x11.6?2.0), FRT distance (28.1?7.8x30.7?7.1) and the median number of SW steps [97.5(60.0-124.0)x131.5(105.0-153.8)], while the CG showed a significant reduction in the mean MMSE scores (23.7?3.7x20.4?4.1) and the FRT (30.6?8.2x27.1?6.9), after the intervention. The IG gains presented medium to large effect sizes, while in the CG the reductions in the MMSE and FR had…

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Background: Traumatic spinal cord injury (TSCI) is a severe, incapacitating, neurological syndrome that leads to changes in sensitivity, motor function, and the autonomic system of body segments located below the level of injury. Although it is one of the most devastating injuries and poses multiple challenges for the patients, family, and clinicians involved, physical therapy can lead to neurological improvements in patients with TSCI. The purpose of this study was to evaluate the effects of corporal suspension and pendulum exercises (CHORDATA? method) on torque, muscle activation, muscle thickness, and functionality in patients with TSCI. Methods: This study was a randomized, controlled clinical trial including 26 male TSCI patients (in whom injury occurred up to 3 years earlier at the thoracic level; age, 18?65 years). The subjects were categorized into two groups: an intervention group (IG; n = 14) and a control group (CG; n = 12). Before and after a rehabilitation program, which comprised 16 sessions of suspension and pendulum exercises (twice/week, 50 minutes/session), we evaluated the following parameters in each subject: maximal voluntary isometric trunk flexion and extension torques; electromyographic activity of the external oblique, rectus abdominis, and longissimus muscles; muscle thickness of the external oblique, internal oblique, transversus abdominis, rectus abdominis, and multifidus muscles; and functionality (adapted reach test). Mean ? standard deviation values were used to summarise continuous data, which were then compared at the baseline using t-tests. Categorical variables were expressed as counts and percentages. Between-group baseline differences were assessed using chi-square or Fisher?s exact tests, as required. Analysis of covariance, with adjustments for baseline measurements, was conducted to evaluate between-group differences after the 16 exercise sessions. The results were presented as mean ? standard deviation with the estimated adjusted difference between groups, followed by 95% confidence intervals. The study significance level was set at ? = 0?05. Data were analysed using SPSS version 22.0 (SPSS, Inc., Chicago, USA).This trial is registered with Clinical Trials.gov,NCT02316067. Findings: The CG and IG patients had similar ages (p = 0?93), injury time (p = 0?41), injury level (p = 0?27), injury…

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Purpose: The aim was to verify the effects of different interventions for lifestyle modifications on the number of diagnosis criteria and clinical aspects involved in Metabolic Syndrome (MS). Methods: A randomized controlled clinical trial including 125 individuals from 30 to 59 years old with MS was conducted in the Rehabilitation Center of PUCRS. Individuals were randomized into three intervention groups: Standard Intervention (SI) ? nonpharmalogical intervention recommended by the guidelines for clinical management of MS, considered the control group in this trial; Group Intervention (GI) ? group lifestyle change implemented weekly by a multidisciplinary team; Individual Intervention (II) ? outpatient care through weekly individual consultations performed by a multidisciplinary team. The outcomes studied include the modification of the number of diagnosis criteria for MS and other clinical parameters such as cardiovascular risk score, Castelli Index (CI) and insulin resistance index HOMA-IR. Each group was assessed at the beginning and at the end of the interventions (three months). Results: Seventy-two individuals concluded the intervention, among them: SI: 19, GI: 25, and II: 28. Groups GI and II presented significant decrease of body mass index, waist circumference, and systolic arterial pressure after three months. The number of diagnosis criteria for MS decreased significantly ? 40% of the individuals did not meet the criteria for the clinical condition studied at the end of the intervention. The largest reduction occurred within group II, where 52% of the individuals presented less than three criteria. Regarding CI and HOMA-IR, both variables were significantly reduced (p < 0.05) in groups GI and II. Conclusion: The interventions proposed by this study reinforce that nonpharmacological strategies for changing lifestyle impact the reduction of cardiovascular risk factors involved in MS. They are also able to remove the population from this clinical condition by decreasing diagnosis criteria.

Objetivos: O objetivo do estudo foi verificar o efeito de diferentes interven??es para modifica??o do estilo de vida sobre o n?mero de crit?rios de diagn?stico e aspectos cl?nicos envolvidos na S?ndrome Metab?lica (SM). M?todos: Foi realizado um ensaio cl?nico randomizado controlado, o qual incluiu 125 indiv?duos de 30-59 anos com SM, conduzido no…

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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES

Importance: The efficacy of combined body suspension with tilting exercises (Chordata Method) in Parkinson?s disease (PD) is unclear. Objective: Design a clinical study to assess the efficacy of body suspension with tilting exercises on functional and quality of life outcomes in PD. Design, Setting, and Participants: This is an assessor-blinded, randomized and controlled clinical trial. A total of 48 subjects with moderate PD were recruited from the Neurological Service of S?o Lucas Hospital, PUCRS, Brazil. Recruitment took place between September 2015 and May 2016. The entire protocol study lasted 16 weeks, with 8 weeks of exercise protocol and 8 weeks of follow-up. Interventions: Subjects were randomly assigned to either body suspension with tilting exercises (intervention group) or stretching exercises (control group). Main Outcomes and Measures: The primary outcome was the Timed Up and Go test at the 8th week. Secondary outcomes were Berg Balance Scale (BBS); Functional Reach Test (FRT); Unified Parkinson?s Disease Rating Scale (UPDRS) and Parkinson?s Disease Questionnaire (PDQ-39). These measures were assessed at baseline (before trial entry) and then at the 8th (end of exercise protocols) and 16th weeks (8 weeks of follow-up) after randomization. Results: Of the 48 subjects randomized in the study 20 received the intervention (71.3?6.3 years old) and 20 were controls (66.7?6.4 years old). Eight of them were lost during the trial (four per group). Analysis of co-variance, with adjustment for baseline measurement, revealed a between-group difference in the Timed Up and Go test at 8th week [CI95% difference of -4.90 (-5.80 a -4.00), p<0.0001] and in the follow-up [CI95% difference of -4.94 sec (-5.82 to -4.06), p<0.0001], which was our primary outcome. Significant between-groups differences were also found for all secondary outcomes (BBS, UPDRS-III, FRT, and PDQ-39) at 8th week and follow-up (16th week) assessments. Conclusions and…

Submitted by Barroso Patr??cia ([email protected]) on 2013-08-12T18:06:45Z No. of bitstreams: 1 Disserta????o Vanessa.pdf: 2305789 bytes, checksum: fa385fab759241e1463e111c509f20a5 (MD5)

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A inser????o da Fonoaudiologia no estado da Bahia tem se configurado num aumento do n??mero de profissionais, na instala????o de cursos de gradua????o e, por conseguinte, na oferta de novas op????es curriculares. A evolu????o das Diretrizes Curriculares Nacionais, as mudan??as mercadol??gicas no campo do trabalho fonoaudiol??gico, as demandas de sa??de da coletividade e a participa????o deste profissional no Sistema ??nico de Sa??de t??m suscitado profundas reflex??es quanto ?? forma????o do fonoaudi??logo. Em face destas constata????es, questiona-se o perfil dos profissionais que exercem a doc??ncia em Fonoaudiologia e o alcance das metas estabelecidas pelos respectivos projetos pedag??gicos. Objetivo: delinear o perfil acad??mico-profissional dos docentes com forma????o em Fonoaudiologia e nas ??reas correlatas respons??veis pelo planejamento e execu????o dos Cursos de Gradua????o em Fonoaudiologia instalados no Estado da Bahia. Metodologia: a presente pesquisa tem car??ter observacional, descritiva e anal??tica, com abordagem quantitativa/ qualitativa, atrav??s do qual foi estudado o universo de docentes fonoaudi??logos, uma amostra de docentes de ??reas correlatas e de discentes matriculados no primeiro, quinto e ??ltimo semestres vinculados aos quatro cursos de gradua????o instalados no estado da Bahia, mediante a aplica????o de instrumento de natureza mista, question??rios, entrevista com os coordenadores de cursos e chefes de departamento. Foram analisados tamb??m, os projetos pedag??gicos e as diretrizes curriculares nacionais. Resultados: A an??lise das quatro institui????es de ensino superior que mant??m o Curso de Gradua????o em Fonoaudiologia no estado da Bahia revelou possuir quadro funcional de professores, majoritariamente, do sexo feminino e adulto jovem, sendo que parcela relevante exerce a doc??ncia em uma ??nica IES. Al??m do t??tulo de especializa????o ?? expressivo o n??mero de mestres e em menor propor????o o quantitativo de doutores. ?? acentuado o n??mero de professores provenientes de outros estados da federa????o com ??nfase ao estado de S??o Paulo. A forma????o acad??mico-profissional dos docentes fonoaudi??logos e daqueles respons??veis pelo ensino de ??reas correlatas tem caracter??sticas profissionais, eminentemente, tecnicistas e especializadas. Em geral os estudantes demonstram satisfa????o e reconhecimento com a qualidade do curso ao qual est??o vinculados, assim como a maioria dos professores consideram que terem tido boa forma????o profissional. Conclus??es: a forma????o acad??mico-profissional dos docentes fonoaudi??logos e daqueles respons??veis pelo ensino de ??reas correlatas t??m…

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Made available in DSpace on 2020-06-02T17:50:12Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) ana_caiane_rocha_silva.pdf: 1767482 bytes, checksum: be990c0a164698fff2bb44eca29603e3 (MD5) Previous issue date: 2019

Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)

Introdu??o: Pacientes com doen?a renal cr?nica (DRC) dial?tica apresentam altera??es da estrutura e fun??o muscular, com consequente comprometimento f?sico, o que coloca a avalia??o funcional como um componente fundamental dos protocolos de avalia??o nessa popula??o. Os testes validados para avalia??o desses indiv?duos, em sua maioria, s?o destinados a avalia??o de estruturas e fun??es corporais que, muitas vezes, n?o mimetizam as atividades de vida di?ria. O teste Glittre Activities Daily Living (Glittre ADL) emerge como uma alternativa mais representativa das atividades cotidianas, por integrar diversas habilidades motoras utilizadas nas tarefas di?rias. Assim, poderia ser uma ferramenta ?til para avalia??o de pessoas com DRC dial?tica. Objetivo: avaliar as respostas hemodin?micas do Glittre ADL teste e sua associa??o com par?metros funcionais em indiv?duos com DRC em hemodi?lise. M?todos: Trata-se de um estudo transversal anal?tico, onde pessoas em hemodi?lise h? mais de tr?s meses foram avaliadas quanto a for?a de preens?o palmar (FPP), for?a muscular respirat?ria, resist?ncia e for?a dos membros inferiores, velocidade da marcha, Short Physical Performance Battery (SPPB), Glittre ADL, qualidade de vida relacionada ? sa?de (QVRS) e perfil de atividade humana (PAH). As correla??es foram avaliadas pelos coeficientes de Pearson ou Spearman e as compara??es pelos testes-t student, Mann Withney ou ANOVA one way, conforme apropriado. Resultados: A amostra foi composta por 91 indiv?duos (53,9% homens) com idade de 52,4 anos (IC95% 49,0 ? 55,8). A frequ?ncia card?aca e a press?o arterial sist?lica aumentaram em 12,1 bpm (IC95% 10,1 ? 14,1) e 18,9 mmHg (IC95% 16,0 ? 21,7) ap?s o teste Glittre ADL, respectivamente, com sensa??o de esfor?o de 2,9 (IC95% 2,2 ? 3,5) pela escala modificada de Borg. Houve correla??es moderadas do Glittre ADL com a for?a muscular inspirat?ria (r=-0,44) e expirat?ria (r=-0,44), FPP (r=-0,55), velocidade da marcha (r=0,66) e for?a e endurance dos membros inferiores (r=0,62 e -0,61, respectivamente). Forte correla??o foi observada com o SPPB (r=-0,70). Fraca corre??o…

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Made available in DSpace on 2018-07-18T13:14:36Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) sueli_ferreira_fonseca.pdf: 2207045 bytes, checksum: cbbd1940c41e5fff7fb9ea96ff6381c6 (MD5) Previous issue date: 2017

Existem evid?ncias que a estimula??o colin?rgica central aumenta a dissipa??o de calor em ratos normotensos como consequ?ncia de altera??es cardiovasculares via modula??o da atividade barorreflexa. No entanto, n?o h? dados publicados sobre o envolvimento do sistema colin?rgico central nestas respostas em modelo experimental que apresenta altera??o da sensibilidade dos barorreceptores e d?ficit termorregulat?rio. Assim, o objetivo do presente estudo foi verificar o envolvimento do sistema colin?rgico central na modula??o das repostas cardiovasculares e termorregulat?rias durante o repouso e exerc?cio f?sico em ratos espontaneamente hipertensos (SHR). Ratos Wistar machos (n = 33) e SHR (n = 33) foram implantados com uma c?nula intracerebroventricular (icv) para inje??es de 2 ?L de fisostigmina (fis) ou solu??o salina (sal). Temperaturas da cauda (Tcauda) e corporal interna (Tint), press?o arterial sist?lica (PAS), frequ?ncia card?aca (FC) e taxa metab?lica foram registradas durante os 60 minutos em que os ratos permaneceram em repouso, bem como durante o exerc?cio f?sico at? a fadiga ap?s inje??es icv randomizadas. Na situa??o repouso, o tratamento com fis iniciou uma sucess?o de respostas cardiovasculares e termorregulat?rias que resultaram em aumento da PAS, redu??o da FC e aumento de Tcauda nos grupos Wistar e SHR. A magnitude da ativa??o desses mecanismos foi mais intensa no SHR, afetando a Tint e melhorando a dissipa??o de calor. Durante o exerc?cio f?sico, o tratamento com fis foi capaz de modular as repostas cardiovasculares promovendo aumento significativo da PAS, seguido de bradicardia reflexa em ratos SHR e Wistar. Estas respostas foram mais intensas nos ratos Wistar. N?o houve diferen?a significativa para a Tcauda e Tint no grupo SHR fis em rela??o ao grupo sal. Entretanto, fis impactou positivamente no desempenho f?sico. Em conjunto, esses resultados fornecem evid?ncias que, durante a situa??o de repouso, a estimula??o colin?rgica central modula as repostas termorregulat?rias por meio de mudan?as no sistema cardiovascular de ratos Wistar e SHR, sendo que essas respostas s?o mais acentuadas em ratos SHR impactando na dissipa??o de calor. Durante o…