subject:( Ethinylestradiol)

University of Ottawa

1. Al-Ansari, Ahmed. Bioaccumulation of 17α-Ethinylestradiol in Fish .

Degree: 2012, University of Ottawa

► The active synthetic constituent of oral contraceptives 17α- ethinylestradiol (EE2) and its natural steroidal estrogen analogues are being released into the aquatic environment mainly via… (more)

▼ The active synthetic constituent of oral contraceptives 17α- ethinylestradiol (EE2) and its natural steroidal estrogen analogues are being released into the aquatic environment mainly via wastewater treatment plants (WWTPs). Although steroidal estrogens have been frequently reported in very low concentrations in the environment, they have been placed at the top of the list of endocrine disrupting chemicals (EDCs) for their high estrogenic activity in non-target aquatic species like fish and frogs. Almost 30 years worth of intensive research has moved the problem of endocrine disruption in the aquatic environment from being a hypothesis to a well-known cause-and-effect story. However, the fate and effects of many pharmaceuticals, including EE2, remain poorly understood. Thus, the main objective of this thesis was to investigate EE2 bioaccumulation in fish by field and laboratory studies. An optimized sample preparation and analytical method protocol was achieved to detect EE2 in its biologically active form in whole fish tissue at trace levels (ng/g). Shorthead redhorse suckers (ShRHS) (Moxostoma macrolepidotum) collected in proximity to a WWTP in the St. Clair River have significantly accumulated EE2 with an average of 1.5 ng/g. EE2 bioaccumulation was limited to fish exhibiting intersex and with induced vitellogenin (VTG). EE2 was absent in fish from a reference site. Positive correlations between EE2 and lipid content as well as "15N supported the hypothesis of EE2 bioaccumulation in wild ShRHSs. A wider survey was carried out to explore patterns of EE2 bioaccumulation in the pelagic and benthic food-wed of the St. Clair IV River, Ontario. In the WWTP effluents and nearby surface waters, EE2 levels were extremely low and below our method detection limits. All of the seven sampled species from different trophic levels and the sediment samples collected from the impacted sites and the reference sites did not have any measurable EE2 concentrations. A laboratory controlled study where male goldfish (Carassius auratus) were exposed to EE2 via water versus food demonstrated that fish can rapidly accumulate EE2 by both routes of exposure. The uptake constant for water was 45 h-1 and the bioconcentration factor for EE2 in fish was 377. The fast uptake rate of EE2 via water coincided with a much slower elimination rate constant of 0.0786 h-1. The assimilation efficiency of 0.106 for EE2 by goldfish was determined by EE2 dietary exposure, which was used to predict EE2 accumulation under different exposure scenarios. The work presented here was the first demonstration of EE2 bioaccumulation in wild fish and the first to model EE2 bioaccumulation from water and dietary exposure in laboratory-exposed fish.

Subjects/Keywords: 17α- ethinylestradiol; bioaccumulation; fish

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APA (6^th Edition):

Al-Ansari, A. (2012). Bioaccumulation of 17α-Ethinylestradiol in Fish . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/22684

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Al-Ansari, Ahmed. “Bioaccumulation of 17α-Ethinylestradiol in Fish .” 2012. Thesis, University of Ottawa. Accessed April 15, 2021. http://hdl.handle.net/10393/22684.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Al-Ansari, Ahmed. “Bioaccumulation of 17α-Ethinylestradiol in Fish .” 2012. Web. 15 Apr 2021.

Vancouver:

Al-Ansari A. Bioaccumulation of 17α-Ethinylestradiol in Fish . [Internet] [Thesis]. University of Ottawa; 2012. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10393/22684.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Al-Ansari A. Bioaccumulation of 17α-Ethinylestradiol in Fish . [Thesis]. University of Ottawa; 2012. Available from: http://hdl.handle.net/10393/22684

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

2. Bílková, Zuzana. Odstraňování reziduí specifického antropogenního znečištění vody organickými látkami s hormonálními účinky při úpravě na vodu pitnou: Elimination of residues of specific antropogenic organic contaminants with hormonal activities of water during drinking water treatment.

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/8341

► Submitted master's thesis is dealing with the problem of occurrence of residues of specific anthropogenic pollution of drinking water sources, with accent on possibilities of… (more)

Subjects/Keywords: znečištění zdrojů pitné vody; úprava vody; estradiol; ethinylestradiol; contamination of drinking water sources; drinking water treatment; estradiol; ethinylestradiol

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APA (6^th Edition):

Bílková, Z. (2018). Odstraňování reziduí specifického antropogenního znečištění vody organickými látkami s hormonálními účinky při úpravě na vodu pitnou: Elimination of residues of specific antropogenic organic contaminants with hormonal activities of water during drinking water treatment. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/8341

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bílková, Zuzana. “Odstraňování reziduí specifického antropogenního znečištění vody organickými látkami s hormonálními účinky při úpravě na vodu pitnou: Elimination of residues of specific antropogenic organic contaminants with hormonal activities of water during drinking water treatment.” 2018. Thesis, Brno University of Technology. Accessed April 15, 2021. http://hdl.handle.net/11012/8341.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bílková, Zuzana. “Odstraňování reziduí specifického antropogenního znečištění vody organickými látkami s hormonálními účinky při úpravě na vodu pitnou: Elimination of residues of specific antropogenic organic contaminants with hormonal activities of water during drinking water treatment.” 2018. Web. 15 Apr 2021.

Vancouver:

Bílková Z. Odstraňování reziduí specifického antropogenního znečištění vody organickými látkami s hormonálními účinky při úpravě na vodu pitnou: Elimination of residues of specific antropogenic organic contaminants with hormonal activities of water during drinking water treatment. [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/11012/8341.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bílková Z. Odstraňování reziduí specifického antropogenního znečištění vody organickými látkami s hormonálními účinky při úpravě na vodu pitnou: Elimination of residues of specific antropogenic organic contaminants with hormonal activities of water during drinking water treatment. [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/8341

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Kumhar, Sunil Kumar. Proniosomal transdermal drug delivery system of Estradiol, Ethinylestradiol and levonorgestrel for contraception and hormone replacement therapy; -.

Degree: Pharmacy, 2004, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/16020

None

Bibliography p. 141-157, include list of chemical

Advisors/Committee Members: Chandra, Ramesh.

Subjects/Keywords: Pharmacy; Drug; levonorgestrel; Ethinylestradiol

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APA (6^th Edition):

Kumhar, S. K. (2004). Proniosomal transdermal drug delivery system of Estradiol, Ethinylestradiol and levonorgestrel for contraception and hormone replacement therapy; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/16020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kumhar, Sunil Kumar. “Proniosomal transdermal drug delivery system of Estradiol, Ethinylestradiol and levonorgestrel for contraception and hormone replacement therapy; -.” 2004. Thesis, Bundelkhand University. Accessed April 15, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/16020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kumhar, Sunil Kumar. “Proniosomal transdermal drug delivery system of Estradiol, Ethinylestradiol and levonorgestrel for contraception and hormone replacement therapy; -.” 2004. Web. 15 Apr 2021.

Vancouver:

Kumhar SK. Proniosomal transdermal drug delivery system of Estradiol, Ethinylestradiol and levonorgestrel for contraception and hormone replacement therapy; -. [Internet] [Thesis]. Bundelkhand University; 2004. [cited 2021 Apr 15]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kumhar SK. Proniosomal transdermal drug delivery system of Estradiol, Ethinylestradiol and levonorgestrel for contraception and hormone replacement therapy; -. [Thesis]. Bundelkhand University; 2004. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

4. Schilling, Cory. Mechanisms of reproductive inhibition in zebrafish (Danio rerio) exposed to ethinylestradiol, nitrate and ammonia.

Degree: MS, Department of Integrative Biology, 2015, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9143

► The objective of this thesis was to investigate the reproductive effects and mechanisms of action of three common MWWE constituents, 17α-ethinylestradiol (EE2), nitrate and ammonia,… (more)

Subjects/Keywords: zebrafish; reproductive physiology; effluent; ethinylestradiol; nitrate; ammonia; AOP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schilling, C. (2015). Mechanisms of reproductive inhibition in zebrafish (Danio rerio) exposed to ethinylestradiol, nitrate and ammonia. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9143

Chicago Manual of Style (16^th Edition):

Schilling, Cory. “Mechanisms of reproductive inhibition in zebrafish (Danio rerio) exposed to ethinylestradiol, nitrate and ammonia.” 2015. Masters Thesis, University of Guelph. Accessed April 15, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9143.

MLA Handbook (7^th Edition):

Schilling, Cory. “Mechanisms of reproductive inhibition in zebrafish (Danio rerio) exposed to ethinylestradiol, nitrate and ammonia.” 2015. Web. 15 Apr 2021.

Vancouver:

Schilling C. Mechanisms of reproductive inhibition in zebrafish (Danio rerio) exposed to ethinylestradiol, nitrate and ammonia. [Internet] [Masters thesis]. University of Guelph; 2015. [cited 2021 Apr 15]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9143.

Council of Science Editors:

Schilling C. Mechanisms of reproductive inhibition in zebrafish (Danio rerio) exposed to ethinylestradiol, nitrate and ammonia. [Masters Thesis]. University of Guelph; 2015. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9143

Brunel University

5. Onogbosele, Cyril Oziegbe. Bioavailability of organic contaminants in rivers.

Degree: PhD, 2015, Brunel University

URL: http://bura.brunel.ac.uk/handle/2438/11050 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655893

► In rivers, association of organic contaminants with dissolved organic carbon may limit freely dissolved or bioavailable fractions and toxicity of organic contaminants. Consequently, assessment of… (more)

▼ In rivers, association of organic contaminants with dissolved organic carbon may limit freely dissolved or bioavailable fractions and toxicity of organic contaminants. Consequently, assessment of toxicity of organic contaminants on the basis of their total chemical concentrations may lead to overestimation of risks to organic contaminants. Therefore, to achieve reliable and accurate risks assessment for organic contaminants, determination of bioavailability is important. The influence of humic acid on the bioavailability of organic contaminants in rivers was studied, using three chemicals with different properties as model contaminants, which at the start of the study were detected in wastewater effluents. It was hypothesized that in the presence of dissolved organic carbon, a fraction of the total concentration of an organic contaminant would not be bioavailable in river water. Therefore, the aim of the study was to determine bioavailability and its impact on toxicity. Bioavailability in the presence of humic acid was determined chemically and using a yeast estrogen screen assay. The chemical method comprised solid-phase extraction and liquid chromatography-mass spectrometry to determine freely dissolved and the fraction of the chemicals associated with dissolved organic carbon. The results indicated increased binding to dissolved organic carbon with the hydrophobicity of the test compounds except for perfluorooctane sulfonate. The dissolved organic carbon-water partition coefficient for ethinylestradiol was determined to be Log KDOC 2.36. Log KDOC values of 4.15 and 4.41 at 10 and 100 mg/L humic acid, respectively, were derived for hexabromocyclododecane indicating greater binding than ethinylestradiol due to the more hydrophobic character. The yeast estrogen screen was used as a biological method to measure the effect of humic acid on the bioavailability of ethinylestradiol and a more hydrophobic compound, dichlorodiphenyltrichloroethane. Results of the yeast estrogen screen indicated that the presence of humic acid had no effect on bioavailability of either of the chemicals.

Subjects/Keywords: 363.739; Ethinylestradiol; Perfluorooctane sulfonate; Hexabromocyclododecane; Dissolved organic carbon; Yeast estrogen screen

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APA (6^th Edition):

Onogbosele, C. O. (2015). Bioavailability of organic contaminants in rivers. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/11050 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655893

Chicago Manual of Style (16^th Edition):

Onogbosele, Cyril Oziegbe. “Bioavailability of organic contaminants in rivers.” 2015. Doctoral Dissertation, Brunel University. Accessed April 15, 2021. http://bura.brunel.ac.uk/handle/2438/11050 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655893.

MLA Handbook (7^th Edition):

Onogbosele, Cyril Oziegbe. “Bioavailability of organic contaminants in rivers.” 2015. Web. 15 Apr 2021.

Vancouver:

Onogbosele CO. Bioavailability of organic contaminants in rivers. [Internet] [Doctoral dissertation]. Brunel University; 2015. [cited 2021 Apr 15]. Available from: http://bura.brunel.ac.uk/handle/2438/11050 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655893.

Council of Science Editors:

Onogbosele CO. Bioavailability of organic contaminants in rivers. [Doctoral Dissertation]. Brunel University; 2015. Available from: http://bura.brunel.ac.uk/handle/2438/11050 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655893

University of Minnesota

6. Kadlec, Sarah. Evaluation of testicular oocytes and gonadal development in smallmouth bass (Micropterus dolomieu) under presumed and known exposure to estrogenic compounds.

Degree: PhD, Integrated Biosciences, 2017, University of Minnesota

URL: http://hdl.handle.net/11299/198386

► Testicular oocytes (TOs), a form of gonadal intersex, have been found in black basses (Micropterus spp.) from many locations in North America. The presence of… (more)

▼ Testicular oocytes (TOs), a form of gonadal intersex, have been found in black basses (Micropterus spp.) from many locations in North America. The presence of TOs is often assumed to imply exposure to estrogenic endocrine disrupting compounds (EDCs), however, a definitive causal relationship has yet to be established, and TO prevalence is not consistently low in fish from areas lacking evident EDC sources. This could suggest unknown or unidentified EDC sources, or that TOs can be stimulated by other stressors, or that they arise spontaneously during normal development. The goal of this dissertation research was to improve our ability to interpret observations of TOs in smallmouth bass (M. dolomieu) in particular, with approaches that are applicable to any other species. These approaches included statistical analysis of TO occurrence in wild populations where estrogenic exposure is more and less likely, and laboratory studies to characterize the early gonadal development in smallmouth bass, both in the presence and absence of exogenous estrogen. TO occurrence in smallmouth bass was assessed in eight watersheds in Northeastern Minnesota watersheds with differing degrees of human development, and hence, likelihood of EDC exposure. Testicular tissues from mature fish were evaluated using a semi-quantitative method that estimated TO density, normalized by cross-sectional area. TO prevalence and density among populations from more developed watersheds were higher than in populations from less developed watersheds. However, TO prevalence was unexpectedly high and variable (7-43%) in some populations from less developed watersheds, and only weak evidence was found for a relationship between TO density and watershed development, suggesting alternative or more complex explanations for TO presence in smallmouth bass. To characterize early gonadal development in smallmouth bass, both in the presence and absence of estrogen, swim-up fry were exposed to control water or the potent model estrogen, 17α-ethinylestradiol (EE2), for 90 days, and reared for another 90 days in clean water. Development of gonadal tissue was assessed at 11 time points using standard histology methods. Ovarian differentiation was observed in 50% of control fish by test day 49, and testicular differentiation occurred by day 92. Among EE2-exposed groups, ovarian phenotypes were observed in 83% of fish by day 49, and in 98% of fish between days 92 and 180, indicating that EE2 can cause complete, and likely permanent, sex reversal in smallmouth bass. Among the EE2-exposed fish that developed ovaries between days 92 and 180, 38% had abnormal characteristics, suggesting that ovaries in sex reversed males can be distinguished from ovaries in genetic females. In a second laboratory study, smallmouth bass gonadal development was assessed during early life stage exposure across a range of concentrations of EE2, including environmentally realistic concentrations. 97% of fish exposed to 4.3 ng/L EE2 (mean measured concentration) had ovaries on test days…

Subjects/Keywords: Ecotoxicology; Endocrine disrupting compounds; Ethinylestradiol; Gonadal development; Sexual differentiation; Smallmouth bass

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kadlec, S. (2017). Evaluation of testicular oocytes and gonadal development in smallmouth bass (Micropterus dolomieu) under presumed and known exposure to estrogenic compounds. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/198386

Chicago Manual of Style (16^th Edition):

Kadlec, Sarah. “Evaluation of testicular oocytes and gonadal development in smallmouth bass (Micropterus dolomieu) under presumed and known exposure to estrogenic compounds.” 2017. Doctoral Dissertation, University of Minnesota. Accessed April 15, 2021. http://hdl.handle.net/11299/198386.

MLA Handbook (7^th Edition):

Kadlec, Sarah. “Evaluation of testicular oocytes and gonadal development in smallmouth bass (Micropterus dolomieu) under presumed and known exposure to estrogenic compounds.” 2017. Web. 15 Apr 2021.

Vancouver:

Kadlec S. Evaluation of testicular oocytes and gonadal development in smallmouth bass (Micropterus dolomieu) under presumed and known exposure to estrogenic compounds. [Internet] [Doctoral dissertation]. University of Minnesota; 2017. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/11299/198386.

Council of Science Editors:

Kadlec S. Evaluation of testicular oocytes and gonadal development in smallmouth bass (Micropterus dolomieu) under presumed and known exposure to estrogenic compounds. [Doctoral Dissertation]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/198386

Universidade Estadual de Campinas

7. Jacob, Juliana de Morais, 1971-. Avaliação da viabilidade da suplementação do ácido fólico através de sua administração concomitante ao etinilestradiol e levonorgestrel em voluntárias sadias.

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Farmacologia, 2020, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/344529

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Orientador: Gilberto de Nucci

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2020-07-07T21:47:47Z (GMT). No. of bitstreams:… (more)

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Orientador: Gilberto de Nucci

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2020-07-07T21:47:47Z (GMT). No. of bitstreams: 1 Jacob_JulianaDeMorais_M.pdf: 10376534 bytes, checksum: 2b58722888b53ab2a00e420622487b1d (MD5) Previous issue date: 2020

Resumo: Defeito do tubo neural (DTN) trata-se de uma malformação congênita resultante de um mal fechamento do tubo neural. Ocorre quando a placa neural embrionária falha em completar seu desenvolvimento e não se fecha em algum ponto ao longo do seu crescimento, por volta da quarta semana do desenvolvimento embrionário. Trata-se de uma má formação fetal que pode ser evitada com a utilização do ácido fólico desde o período pré concepcional até os primeiros meses de vida da criança. O folato é essencial e sua deficiência pode ser causada por dieta inadequada, por fatores genéticos ou pela interação de fatores genéticos e ambientais. A suplementação com ácido fólico previne 50-75% dos casos de defeitos do tubo neural. Este estudo objetivou avaliar a viabilidade da realização de suplementação do ácido fólico juntamente com anticoncepcional com a administração de etinilestradiol 0,02 mg + levonorgestrel 0,10 mg + ácido fólico 0,4 mg em comprimidos de administração oral, com base em comparações estatísticas dos níveis de folato no sangue. As concentrações foram medidas através de método analítico apropriado e validado, bem como avaliado sua segurança e tolerabilidade em voluntárias sadias do sexo feminino. Trata-se de um estudo de Fase II, monocêntrico, aberto, com um tratamento em três ciclos, com administração em doses múltiplas, nos quais as voluntárias recebem o produto teste e posteriormente o placebo. As trinta e seis voluntárias saudáveis receberam um comprimido revestido do produto teste - etinilestradiol 0,02 mg + levonorgestrel 0,10 mg + ácido fólico 0,4 mg por 21 dias e um placebo revestido contendo apenas 0,4 mg de ácido fólico somente nos últimos 7 dias de cada ciclo de tratamento, que foram realizados em 3 ciclos. Amostras de sangue foram coletadas para quantificar o folato por cromatografia líquida acoplada a espectrometria de massa (LC-MS / MS), para mensuração do níveis de folato no sangue antes da primeira administração do primeiro, segundo e terceiro ciclo, após 21 dias do primeiro, segundo e terceiro ciclo e após 28 dias do primeiro, segundo e terceiro ciclo. A segurança foi avaliada pelo registro de eventos adversos, monitoramento de sinais vitais e avaliação de exames laboratoriais e ECG. A média do nível de ácido fólico no sangue no início (1º dia do 1º ciclo) foi de 42,7 ± 22,2 ng/mL enquanto no 28º dia do 3º ciclo foi de 47,6 ± 20,1 ng/mL, com uma variação de 11,32%. As voluntárias toleraram bem o protocolo clínico e não relataram efeitos adversos clinicamente significativos, apenas uma voluntária, por motivos particulares, abandonou o estudo durante a segunda sessão do primeiro ciclo. Os contraceptivos orais estudados nesse protocolo, podem ser considerados um veículo viável…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, De Nucci, Gilberto, 1958-, Gobbato, André Alves de Moraes, Costa, José Luiz da.

Subjects/Keywords: Ácido fólico; Anticoncepcionais; Etinilestradiol; Levanogestrel; Folic acid; Contraceptive agents; Ethinylestradiol; Levonorgestrel

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jacob, Juliana de Morais, 1. (2020). Avaliação da viabilidade da suplementação do ácido fólico através de sua administração concomitante ao etinilestradiol e levonorgestrel em voluntárias sadias. (Masters Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/344529

Chicago Manual of Style (16^th Edition):

Jacob, Juliana de Morais, 1971-. “Avaliação da viabilidade da suplementação do ácido fólico através de sua administração concomitante ao etinilestradiol e levonorgestrel em voluntárias sadias.” 2020. Masters Thesis, Universidade Estadual de Campinas. Accessed April 15, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/344529.

MLA Handbook (7^th Edition):

Jacob, Juliana de Morais, 1971-. “Avaliação da viabilidade da suplementação do ácido fólico através de sua administração concomitante ao etinilestradiol e levonorgestrel em voluntárias sadias.” 2020. Web. 15 Apr 2021.

Vancouver:

Jacob, Juliana de Morais 1. Avaliação da viabilidade da suplementação do ácido fólico através de sua administração concomitante ao etinilestradiol e levonorgestrel em voluntárias sadias. [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2020. [cited 2021 Apr 15]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/344529.

Council of Science Editors:

Jacob, Juliana de Morais 1. Avaliação da viabilidade da suplementação do ácido fólico através de sua administração concomitante ao etinilestradiol e levonorgestrel em voluntárias sadias. [Masters Thesis]. Universidade Estadual de Campinas; 2020. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/344529

8. Derouiche, Lyes. Exposition développementale à l'éthinylestradiol et fonction de reproduction chez la souris : effets neuroendocrines et comportementaux : Developmental exposure to ethinylestradiol and reproductive function in mice : neuroendocrine and behavioral effects.

Degree: Docteur es, Sciences de la vie, 2016, Université François-Rabelais de Tours

URL: http://www.theses.fr/2016TOUR4002

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Les réseaux neuroendocrines qui contrôlent la reproduction sont mis en place pendant le développement sous l’action des stéroïdes sexuels endogènes. Toute perturbation de l’équilibre hormonal… (more)

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Les réseaux neuroendocrines qui contrôlent la reproduction sont mis en place pendant le développement sous l’action des stéroïdes sexuels endogènes. Toute perturbation de l’équilibre hormonal pendant ces phases critiques pourrait être à l’origine de troubles de la fonction de reproduction chez l’adulte. Ce travail vise à identifier l’impact d’une exposition développementale à un oestrogène de synthèse, l’éthinyloestradiol (EE2), sur les réseaux neuroendocrines et les conséquences physiologiques et comportementales chez l’adulte et sa descendance. Nos résultats ont montré que l’EE2 induit des perturbations des comportements sexuels chez les mâles et chez les femelles et une modification des réseaux hypothalamiques à GnRH et des neurones à calbindine qui contrôlent la physiologie et les comportements reproducteurs. Nous avons également montré que certains effets de l’EE2 sont transmis jusqu’à la quatrième génération, mettant ainsi en évidence le caractère transgénérationnel de ces perturbations. Ces résultats mettent en évidence la sensibilité des réseaux neuroendocrines aux perturbateurs endocriniens et la nécessité de prendre en compte ces paramètres dans l’évaluation de leurs effets sur la santé et la reproduction.

Neuroendocrine networks controlling reproductive function are established during development by the action of endogenous sex steroids. Any disturbance in the hormone balance during these critical phases may cause several disorders in reproductive function in adulthood. This work aims at identifing the consequences of a developmental exposure to the synthetic pharmaceutical estrogen ethinylestradiol (EE2) on the neuroendocrine and behavioral outcomes of the reproductive function in adult individuals and their offspring. Our findings showed that EE2 induced disturbances of sexual behaviors in males and females and modified the GnRH and the calbindin hypothalamic networks of exposed animals. We also showed that some effects of EE2 were transmitted up to the fourth generation, pointing out the transgenerational character of certain effects. All these results highlight the sensitivity of neuroendocrine networks to endocrine disruptors and the need to consider these parameters in assessing their effects on health and reproduction.

Advisors/Committee Members: Duittoz, Anne (thesis director), Pillon, Delphine (thesis director).

Subjects/Keywords: Ethinyloestradiol; Neuroendocrine; Reproduction; Perturbateurs endocriniens; Dimorphisme sexuel; Ethinylestradiol; Neuroendocrine; Reproduction; Endocrine disruptors; Sexual dimorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Derouiche, L. (2016). Exposition développementale à l'éthinylestradiol et fonction de reproduction chez la souris : effets neuroendocrines et comportementaux : Developmental exposure to ethinylestradiol and reproductive function in mice : neuroendocrine and behavioral effects. (Doctoral Dissertation). Université François-Rabelais de Tours. Retrieved from http://www.theses.fr/2016TOUR4002

Chicago Manual of Style (16^th Edition):

Derouiche, Lyes. “Exposition développementale à l'éthinylestradiol et fonction de reproduction chez la souris : effets neuroendocrines et comportementaux : Developmental exposure to ethinylestradiol and reproductive function in mice : neuroendocrine and behavioral effects.” 2016. Doctoral Dissertation, Université François-Rabelais de Tours. Accessed April 15, 2021. http://www.theses.fr/2016TOUR4002.

MLA Handbook (7^th Edition):

Derouiche, Lyes. “Exposition développementale à l'éthinylestradiol et fonction de reproduction chez la souris : effets neuroendocrines et comportementaux : Developmental exposure to ethinylestradiol and reproductive function in mice : neuroendocrine and behavioral effects.” 2016. Web. 15 Apr 2021.

Vancouver:

Derouiche L. Exposition développementale à l'éthinylestradiol et fonction de reproduction chez la souris : effets neuroendocrines et comportementaux : Developmental exposure to ethinylestradiol and reproductive function in mice : neuroendocrine and behavioral effects. [Internet] [Doctoral dissertation]. Université François-Rabelais de Tours; 2016. [cited 2021 Apr 15]. Available from: http://www.theses.fr/2016TOUR4002.

Council of Science Editors:

Derouiche L. Exposition développementale à l'éthinylestradiol et fonction de reproduction chez la souris : effets neuroendocrines et comportementaux : Developmental exposure to ethinylestradiol and reproductive function in mice : neuroendocrine and behavioral effects. [Doctoral Dissertation]. Université François-Rabelais de Tours; 2016. Available from: http://www.theses.fr/2016TOUR4002

9. Koumeir, Diala. Élimination des oestrogènes par Ozonation et Photocatalyse : cas de l’éthinylestradiol : Elimination of oestrogenes by ozonation and photocatalyse : case of ethinylestradiol.

Degree: Docteur es, Chimie, 2009, Université Claude Bernard – Lyon I

URL: http://www.theses.fr/2009LYO10285

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Actuellement, les systèmes d’épuration des eaux n’ont pas été conçus pour éliminer les substances médicamenteuses notamment les hormones (estrogènes). Ces molécules sont ainsi déversées dans… (more)

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Actuellement, les systèmes d’épuration des eaux n’ont pas été conçus pour éliminer les substances médicamenteuses notamment les hormones (estrogènes). Ces molécules sont ainsi déversées dans le milieu naturel et contaminent les rivières. Le 17 α-éthinylestradiol a été choisie comme molécule modèle pour illustrer la présence d’un perturbateur endocrinien dans une eau résiduaire. Cette molécule présente un réel risque pour la faune et la flore (Féminisation des poissons mâles, diminution de la reproduction…). L’objectif de ce travail est d’évaluer l’efficacité de la photocatalyse et de l’ozonation pour éliminer l’Ethinylestradiol dans les eaux. Le procédé d’oxydation utilisant l’ozone a été appliqué dans un premier temps sur des solutions concentrées d’éthinylestradiol (EE2 = 10 mg/L) préparées dans une eau ultrapure tamponnée afin de mieux comprendre les mécanismes d’élimination de ce composé et d’évaluer l’efficacité en terme de taux de conversion de EE2 et de la minéralisation du substrat. Les expériences réalisées ont permis de montrer que l’ozone est un oxydant très efficace pour oxyder l’éthinylestradiol. L’oxydation se fait essentiellement par réaction directe de l’ozone sur la molécule d’EE2 alors que sa minéralisation nécessite la conversion de l’ozone en radicaux hydroxyles qui vont ensuite réagir sur la structure saturée de la molécule organique. L’étude de l’ozonation de solutions EE2 à différentes concentrations a permis d’établir une relation entre la concentration initiale en polluant dans l’eau et la dose d’ozone à introduire pour éliminer ce composé à un pH proche de la neutralité. Cette relation a été utilisée pour estimer la dose d’ozone à appliquer pour une eau contaminée par EE2 à une concentration proche de celle rencontrée dans les eaux résiduaires et comparée à celle obtenue sur une eau provenant de la station d’épuration du Bourget du Lac. L’efficacité du procédé photocatalytique a été évaluée en travaillant sur les vitesses de disparition et de minéralisation de EE2 en présence de TiO2 «Degussa P25» et TiO2 PC500. Les cinétiques d’adsorption et de dégradation photocatalytiques ont été évaluées dans une gamme de concentration allant de 1 à 10 mg/L en travaillant à différentes masses de photocatalyseur. Les constantes d’adsorption et de vitesse, modélisés avec les modèles de Langmuir et Langmuir-Hinshelwood respectivement révèlent, (1) des propriétés d’adsorption et de photocatalyse plus importante pour le photocatalyseur TiO2 «Degussa P25», (2) des constantes d’adsorption différentes en présence ou en absence d’irradiation et aucune proportionnalité entre quantité de EE2 adsorbée et concentration en photocatalyseur. Cette absence de corrélation est expliquée en considérant la taille des particules. La formation d’agrégats de plus en plus important est observée en augmentant la masse de TiO2. La minéralisation de EE2 est totale après moins d’une heure d’irradiation en travaillant avec une puissance lumineuse de 5,5 mW/cm2 et 10 mg/L de EE2 indiquant l’efficacité de ce procédé.

Currently,…

Advisors/Committee Members: Guillard, Chantal (thesis director), Guittonneau, Sylvie (thesis director).

Subjects/Keywords: Ozonation; Photocatalyse; Éthinylestradiol; Eaux de traitements; Oestrogène; Ozonation; Photocatalys; Ethinylestradiol; Water treatment; Estrogen; 546

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koumeir, D. (2009). Élimination des oestrogènes par Ozonation et Photocatalyse : cas de l’éthinylestradiol : Elimination of oestrogenes by ozonation and photocatalyse : case of ethinylestradiol. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2009LYO10285

Chicago Manual of Style (16^th Edition):

Koumeir, Diala. “Élimination des oestrogènes par Ozonation et Photocatalyse : cas de l’éthinylestradiol : Elimination of oestrogenes by ozonation and photocatalyse : case of ethinylestradiol.” 2009. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed April 15, 2021. http://www.theses.fr/2009LYO10285.

MLA Handbook (7^th Edition):

Koumeir, Diala. “Élimination des oestrogènes par Ozonation et Photocatalyse : cas de l’éthinylestradiol : Elimination of oestrogenes by ozonation and photocatalyse : case of ethinylestradiol.” 2009. Web. 15 Apr 2021.

Vancouver:

Koumeir D. Élimination des oestrogènes par Ozonation et Photocatalyse : cas de l’éthinylestradiol : Elimination of oestrogenes by ozonation and photocatalyse : case of ethinylestradiol. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2009. [cited 2021 Apr 15]. Available from: http://www.theses.fr/2009LYO10285.

Council of Science Editors:

Koumeir D. Élimination des oestrogènes par Ozonation et Photocatalyse : cas de l’éthinylestradiol : Elimination of oestrogenes by ozonation and photocatalyse : case of ethinylestradiol. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2009. Available from: http://www.theses.fr/2009LYO10285

10. Nihoul, Florent. Ontogénèse de l’axe gonadotrope chez le bar européen (Dicentrarchus labrax) et effets des xénoestrogènes sur sa mise en place : Ontogenesis of gonadotropic axis in European sea bass (Dicentrarchus labrax) and effects of xenoestrogenes on its setting up.

Degree: Docteur es, Biologie des organismes, 2019, Normandie

URL: http://www.theses.fr/2019NORMLH19

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Les perturbateurs endocriniens (PE) sont une préoccupation majeure de par leurs effets sur les grandes fonctions physiologiques des organismes etparticulièrement sur la fonction de reproduction.… (more)

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Les perturbateurs endocriniens (PE) sont une préoccupation majeure de par leurs effets sur les grandes fonctions physiologiques des organismes etparticulièrement sur la fonction de reproduction. Chez les vertébrés, la reproduction est sous le contrôle d’un axe neuroendocrinien nommé axegonadotrope. Celui-ci comprend différents acteurs cérébraux (gonadolibérines et kisspeptines), hypophysaires (gonadotropines) et gonadiques(stéroïdes sexuels) dont la mise en place et le fonctionnement sont régulés finement. Parmi les mécanismes de régulation, les stéroïdes vont jouer unrôle important en effectuant des boucles de rétrocontrôle. Les PE mimant ces stéroïdes sont donc potentiellement capables d’impacter ces régulations.L’objectif de ce travail était d’évaluer les effets d’un xénooestrogène sur les mises en place des acteurs cérébraux impliqués dans l’axe gonadotrope chezle bar européen (Dicentrarchus labrax). Nous avons d’abord décrit l’ontogénèse des systèmes à kisspeptine, à gonadolibérine et à gonadotropine aucours du développement larvaire. Nous avons mis en évidence une régulation différentielle de ces acteurs suggérant un rôle durant ce processusdéveloppemental. De plus, nous montrons que le 17α-éthinylestradiol (EE2) est capable de perturber l'ontogenèse des systèmes à GnRH2 et à GnRH3au cours des stades précoces du développement larvaire.Ces données constituent une base permettant l’évaluation des effets des PE sur l’ontogénèse des systèmes neuroendocriniens.

Endocrine disruptors (EDs) are a major concern because of their effects on the main physiological functions, particularly on the reproductive function.In vertebrates, reproduction is under the control of a neuroendocrine axis called hypothalamic-pituitary-gonadal (HPG) axis. It includes various actors atthe brain (gonadotropin releasing hormones (GnRH) and kisspeptins), pituitary (gonadotropic hormones) and gonadal (sex steroids) levels. Theirdévelopment and functioning are finely regulated. Among the regulators, steroids play an important role by performing feedback loops. EDs mimickingsteroids are therefore potentially able to impact these regulations. The objective of this work was to evaluate the effects of xenoestrogens on theimplementation of cerebral actors involved in the HPG axis in the European sea bass (Dicentrarchus labrax). We first described the ontogeny of thekisspeptin, GnRH and gonadotropin systems during larval development. We have highlighted a differential regulation of these actors suggesting a roleduring this developmental process. In addition, we show that 17α-ethinylestradiol (EE2) is able to disrupt the ontogeny of GnRH2 and GnRH3 systemsduring the early stages of larval development.These data provide a basis for evaluation of the EDs effects on the ontogeny of neuroendocrine systems.

Advisors/Committee Members: Danger, Jean-Michel (thesis director).

Subjects/Keywords: Dicentrarchus labrax; Kisspeptines; GnRH; Gonadotropines; 17a-ethinylestradiol; Pertubation endocrinienne; Neurogénèse; Gonadotropins; Endocrine disruption; Neurogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nihoul, F. (2019). Ontogénèse de l’axe gonadotrope chez le bar européen (Dicentrarchus labrax) et effets des xénoestrogènes sur sa mise en place : Ontogenesis of gonadotropic axis in European sea bass (Dicentrarchus labrax) and effects of xenoestrogenes on its setting up. (Doctoral Dissertation). Normandie. Retrieved from http://www.theses.fr/2019NORMLH19

Chicago Manual of Style (16^th Edition):

Nihoul, Florent. “Ontogénèse de l’axe gonadotrope chez le bar européen (Dicentrarchus labrax) et effets des xénoestrogènes sur sa mise en place : Ontogenesis of gonadotropic axis in European sea bass (Dicentrarchus labrax) and effects of xenoestrogenes on its setting up.” 2019. Doctoral Dissertation, Normandie. Accessed April 15, 2021. http://www.theses.fr/2019NORMLH19.

MLA Handbook (7^th Edition):

Nihoul, Florent. “Ontogénèse de l’axe gonadotrope chez le bar européen (Dicentrarchus labrax) et effets des xénoestrogènes sur sa mise en place : Ontogenesis of gonadotropic axis in European sea bass (Dicentrarchus labrax) and effects of xenoestrogenes on its setting up.” 2019. Web. 15 Apr 2021.

Vancouver:

Nihoul F. Ontogénèse de l’axe gonadotrope chez le bar européen (Dicentrarchus labrax) et effets des xénoestrogènes sur sa mise en place : Ontogenesis of gonadotropic axis in European sea bass (Dicentrarchus labrax) and effects of xenoestrogenes on its setting up. [Internet] [Doctoral dissertation]. Normandie; 2019. [cited 2021 Apr 15]. Available from: http://www.theses.fr/2019NORMLH19.

Council of Science Editors:

Nihoul F. Ontogénèse de l’axe gonadotrope chez le bar européen (Dicentrarchus labrax) et effets des xénoestrogènes sur sa mise en place : Ontogenesis of gonadotropic axis in European sea bass (Dicentrarchus labrax) and effects of xenoestrogenes on its setting up. [Doctoral Dissertation]. Normandie; 2019. Available from: http://www.theses.fr/2019NORMLH19

Universidade Estadual de Campinas

11. Fonseca, Camila Gomes Marchesini, 1989-. Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino.

Degree: Faculdade de Engenharia Civil, Arquitetura e Urbanismo; Programa de Pós-Graduação em Engenharia Civil, 2019, Universidade Estadual de Campinas

URL: FONSECA, Camila Gomes Marchesini. Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino. 2019. 1 recurso online (148 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo, Campinas, SP. Disponível em: http://www.repositorio.unicamp.br/handle/REPOSIP/333621. Acesso em: 26 jul. 2019. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/333621

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Orientadores: Ricardo de Lima Isaac, Alexandre Nunes Ponezi

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo

Made available in… (more)

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Orientadores: Ricardo de Lima Isaac, Alexandre Nunes Ponezi

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo

Made available in DSpace on 2019-07-26T12:45:19Z (GMT). No. of bitstreams: 1 Fonseca_CamilaGomesMarchesini_M.pdf: 20608853 bytes, checksum: fda61066a5624da2136a8661491ef2b8 (MD5) Previous issue date: 2019

Resumo: O estrógeno natural 17ß-estradiol (E2), o estrógeno sintético 17"alfa"-etinilestradiol (EE2) e o herbicida atrazina (ATZ) foram selecionados para se investigar, em escala de laboratório (jar-test), a remoção de compostos orgânicos em matriz aquosa por adsorção em carvão ativado em pó (CAP) e seu correspondente superfino (CAP-SF). Cromatografia líquida de alta eficiência com detector de arranjo de diodos (HPLC-DAD) foi empregada para a identificação e quantificação desses analitos, em duplicata. Amostras de água desionizada e de água bruta foram fortificadas para obtenção de concentrações iniciais de 6,70, 21,64 e 26,47µg/L para ATZ, E2 e EE2, respectivamente. Isotermas de adsorção foram desenvolvidas experimentalmente em água desionizada (temperatura: 20°C; pH: 8,5; dosagens de carvão: 1, 2,5, 5, 10 e 25mg/L; tempo de contato: 2h) sendo obtidos os parâmetros dos modelos de Freundlich e Langmuir. A capacidade adsortiva máxima do CAP seguiu a ordem crescente para ATZ (o mais hidrofílico), EE2 e E2; no caso do CAP-SF, esta ordem foi ATZ, E2 e EE2. O CAP-SF apresentou maior capacidade em adsorver os analitos (maiores valores de K no modelo de Freundlich) e menor potencial em dessorvê-los (maiores valores de n no modelo de Freundlich e de b no de Langmuir, exceto para o EE2) quando comparado ao CAP... O resumo poderá ser visualizado no texto completo da tese digital

Natural estrogen 17ß-estradiol (E2), synthetic estrogen 17"alfa"-ethinylestradiol (EE2) and herbicide atrazine (ATZ) were selected in order to investigate the adsorption removal of organic compounds by powdered activated carbon (PAC) and its superfine correspondent (SF-PAC) in aqueous matrix, at laboratory scale (jar-test). High pressure liquid chromatography plus diode array detector (HPLC-DAD) were applied for analytes detection and quantification, in duplicate. Samples of deionized and raw water were fortified in order to obtain initial concentrations of 6.70, 21.64 and 26.47µg/L for ATZ, E2 and EE2, respectively. Adsorption isotherms were developed experimentally in deionized water (temperature: 20°C, pH: 8.5, carbon dosages: 1, 2.5, 5, 10 and 25mg/L, contact time: 2h) to obtain Freundlich and Langmuir model's parameters... The abstract is available with the full electronic document

Mestrado

Saneamento e Ambiente

Mestra em Engenharia Civil

01P-03713/2018

CAPES

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Ponezi, Alexandre Nunes, 1964-, Isaac, Ricardo de Lima, 1962-, Morita, Dione Mari, Achon, Cali Laguna.

Subjects/Keywords: Adsorção; Atrazina; Estradiol; Etinilestradiol; Tratamento de água; Adsorption; Atrazine; Estradiol; Ethinylestradiol; Water treatment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fonseca, Camila Gomes Marchesini, 1. (2019). Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino. (Masters Thesis). Universidade Estadual de Campinas. Retrieved from FONSECA, Camila Gomes Marchesini. Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino. 2019. 1 recurso online (148 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo, Campinas, SP. Disponível em: http://www.repositorio.unicamp.br/handle/REPOSIP/333621. Acesso em: 26 jul. 2019. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/333621

Chicago Manual of Style (16^th Edition):

Fonseca, Camila Gomes Marchesini, 1989-. “Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino.” 2019. Masters Thesis, Universidade Estadual de Campinas. Accessed April 15, 2021. FONSECA, Camila Gomes Marchesini. Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino. 2019. 1 recurso online (148 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo, Campinas, SP. Disponível em: http://www.repositorio.unicamp.br/handle/REPOSIP/333621. Acesso em: 26 jul. 2019. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/333621.

MLA Handbook (7^th Edition):

Fonseca, Camila Gomes Marchesini, 1989-. “Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino.” 2019. Web. 15 Apr 2021.

Vancouver:

Fonseca, Camila Gomes Marchesini 1. Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino. [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2019. [cited 2021 Apr 15]. Available from: FONSECA, Camila Gomes Marchesini. Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino. 2019. 1 recurso online (148 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo, Campinas, SP. Disponível em: http://www.repositorio.unicamp.br/handle/REPOSIP/333621. Acesso em: 26 jul. 2019. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/333621.

Council of Science Editors:

Fonseca, Camila Gomes Marchesini 1. Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino. [Masters Thesis]. Universidade Estadual de Campinas; 2019. Available from: FONSECA, Camila Gomes Marchesini. Remoção de micropoluentes de interesse emergente em matriz aquosa por adsorção em carvão ativado em pó e superfino. 2019. 1 recurso online (148 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Civil, Arquitetura e Urbanismo, Campinas, SP. Disponível em: http://www.repositorio.unicamp.br/handle/REPOSIP/333621. Acesso em: 26 jul. 2019. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/333621

Universidade Estadual de Campinas

12. Campos, Julyenne Meneghetti, 1985-. Constructed wetlands na retenção de interferentes endócrinos presentes em águas residuárias.

Degree: Faculdade de Engenharia Agrícola; Programa de Pós-Graduação em Engenharia Agrícola, 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334715

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Orientadores: Denis Miguel Roston, Sonia Claudia do Nascimento de Queiroz

Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola

Made available in DSpace… (more)

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Orientadores: Denis Miguel Roston, Sonia Claudia do Nascimento de Queiroz

Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola

Made available in DSpace on 2019-08-20T17:26:05Z (GMT). No. of bitstreams: 1 Campos_JulyenneMeneghetti_D.pdf: 9569198 bytes, checksum: d2e7a2b94716a5cf411615469bac1472 (MD5) Previous issue date: 2018

Resumo: Constructed wetlands são sistemas naturais de tratamento de águas residuárias e de abastecimento, que removem poluentes por macrófitas aquáticas e pelo biofilme formado nas raízes dessas plantas fixadas a um meio suporte. Esse método de tratamento tem como vantagem o baixo custo de implantação e manutenção, economia de energia elétrica durante seu funcionamento, além de serem eficientes na remoção de poluentes. Os poluentes que tem gerado grande preocupação devido aos riscos à saúde humana e ao meio ambiente são os interferentes endócrinos. Essas substâncias estão cada vez mais presentes no meio ambiente, especialmente nos corpos hídricos, e podem causar câncer em seres humanos e animais, mutagenicidade nos órgãos reprodutores das espécies animais presentes na biota aquática, esterilidade em homens, entre outros efeitos adversos à saúde. Portanto a presença dessas substâncias em águas residuárias tem despertado grande preocupação e o uso de métodos para a remoção das mesmas é de extrema relevância e importância. Neste contexto, o presente projeto visou avaliar a eficiência de constructed wetlands de fluxo subsuperficial horizontal, em escala de bancada, na retenção/remoção dos interferentes endócrinos: bisfenol A (BPA), etinilestradiol (EE2) e levonorgestrel (LNG) adicionados à esgoto sintético previamente preparado. Foram utilizados quatro diferentes tipos de wetlands: três contendo brita como meio suporte, uma cultivada com Cyperus isocladus (WL1), uma sem macrófita (WL2) e outra cultivada com Eichhornia crassipes (WL3); a quarta wetland (WLC) possuía além da brita, carvão de bambu (Dendrocalamus asper) como meio suporte, e foi cultivada com a mesma macrófita de WL1. Foram avaliados também a toxicidade do esgoto sintético, a adsorção no meio suporte utilizado, e a absorção dos interferentes endócrinos pelas macrófitas. Parâmetros físico-químicos como pH, demanda química de oxigênio, carbono orgânico dissolvido, série de sólidos, série de nitrogênio, e fósforo total, assim como a quantidade de biomassa, e concentração de macro e micronutrientes nas macrófitas também foram avaliados. As retenções médias de BPA foram de 80,7 (± 6%) em WLC, para WL1 42,3 (± 16,8%), em WL2 30,2 (± 19,5%) e para WL3 20,0 (± 21,1%). Para EE2 as retenções médias foram 85,2 (± 3,4%) para WLC, 51,4 (± 9,7%) em WL1, 23,3 (± 17,6%) em WL2 e 55,4 (± 4,3%) em WL3. Para o hormônio LNG a WLC obteve retenção de 82,7 (± 5,0%), 74,2 (± 9,3%) em WL1, 81,2 (± 5,0%) em WL2 e por fim, 82,8 (± 6,8) em WL3. Com os resultados obtidos, conclui-se que as constructed wetlands avaliadas são sistemas eficientes de tratamento de interferentes endócrinos em águas residuárias, podendo ser…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Queiroz, Sonia Claudia do Nascimento de, Roston, Denis Miguel, 1951-, Silva, Ariovaldo José da, Valentim, Marcelus Alexander Acorinte, Stefanutti, Ronaldo.

Subjects/Keywords: Leitos cultivados; Bisfenol A; Etinilestradiol; Levonorgestrel; Macrofitas; Constructed wetlands; Bisphenol A; Ethinylestradiol; Levonorgestrel; Macrophytes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Campos, Julyenne Meneghetti, 1. (2018). Constructed wetlands na retenção de interferentes endócrinos presentes em águas residuárias. (Doctoral Dissertation). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/334715

Chicago Manual of Style (16^th Edition):

Campos, Julyenne Meneghetti, 1985-. “Constructed wetlands na retenção de interferentes endócrinos presentes em águas residuárias.” 2018. Doctoral Dissertation, Universidade Estadual de Campinas. Accessed April 15, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/334715.

MLA Handbook (7^th Edition):

Campos, Julyenne Meneghetti, 1985-. “Constructed wetlands na retenção de interferentes endócrinos presentes em águas residuárias.” 2018. Web. 15 Apr 2021.

Vancouver:

Campos, Julyenne Meneghetti 1. Constructed wetlands na retenção de interferentes endócrinos presentes em águas residuárias. [Internet] [Doctoral dissertation]. Universidade Estadual de Campinas; 2018. [cited 2021 Apr 15]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334715.

Council of Science Editors:

Campos, Julyenne Meneghetti 1. Constructed wetlands na retenção de interferentes endócrinos presentes em águas residuárias. [Doctoral Dissertation]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334715

Universidade Estadual de Campinas

13. Campos, Julyenne Meneghetti, 1985-. Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol.

Degree: Faculdade de Engenharia Agrícola; Programa de Pós-Graduação em Engenharia Agrícola, 2014, Universidade Estadual de Campinas

URL: CAMPOS, Julyenne Meneghetti. Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol. 2014. 225 p. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/257506>. Acesso em: 24 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/257506

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Orientador: José Teixeira Filho

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola

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Orientador: José Teixeira Filho

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola

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Resumo: Leitos cultivados tem sido citados como um método alternativo de redução da concentração de alguns agrotóxicos e hormônios levemente hidrofóbicos, como o 17-?-etinilestradiol, que é um dos principais responsáveis pela causa da alteração no sistema endócrino de humanos e animais. Neste contexto, o presente projeto visou avaliar a eficiência da redução de pH, 17-?-etinilestradiol, oxigênio dissolvido (OD), cor aparente, turbidez, nitrogênio total Kjeldahl (NTK), nitrogênio amoniacal (NH3), nitrito (NO2-), nitrato (NO3-), demanda química de oxigênio (DQO) e fósforo total (PT), utilizando-se três leitos tendo brita como meio suporte ¿ dois deles cultivados com a macrófita Eichhornia crassipes (aguapé), com 43 dias de diferença de cultivo entre eles, e outro leito sem cultivo apenas com a brita para controle e comparação dos resultados. A vazão de entrada nos leitos cultivados variou entre 312 e 1.059 L.dia-1, o TDH médio permaneceu entre 2 e 3 dias, as médias máximas de retenção da concentração de DQO, cor, turbidez, NTK, NH3 e PT pelos leitos foram 94,2%, 76,7%, 90,0%, 42,7%, 39,6% e 51,0%, respectivamente. A biomassa dos dois leitos cultivados com aguapé absorveram juntos, 163 g.kg-1 de nitrogênio e 47,2 g.kg-1 de fósforo, durante o período monitorado. Dentre os parâmetros de eficiência analisados o leito cultivado com Eichhornia crassipes com maior grau de desenvolvimento foi o mais eficiente na retenção da maioria dos parâmetros avaliados com nível 5% de significância. A metodologia adaptada para análise do hormônio 17-?-etinilestradiol por Cromatografia Líquida de Alta Eficiência acoplada à Detector de Arranjo de Diodos obteve limite de detecção de 1,26 µg.L-1, e limite de quantificação de 2,52 µg.L-1, porém as amostras analisadas ficaram abaixo do nível de detecção, não sendo possível a determinação das concentrações das amostras. Conclui-se que a macrófita Eichhornia crassipes fixada em meio suporte obteve retenções de nutrientes consideradas satisfatórias em tratamento de esgoto doméstico, e as informações obtidas por este trabalho poderão contribuir com a melhoria e desenvolvimento de novas tecnologias para retenção e métodos analíticos para quantificação de 17-?-etinilestradiol em águas residuárias, diminuindo o lançamento destes interferentes endócrinos nos corpos hídricos

Constructed wetlands have been quoted as an alternative method for the removal of slightly hydrophobic pesticides and hormones, such as 17-?-ethinylestradiol, which is one of the main hormones responsible for humans and animals endocrine systems changes. In this context, this project tried to evaluate the reduction efficiency with regards to pH, 17-?-ethinylestradiol, dissolved oxygen (DO), apparent…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Teixeira Filho, José, 1955-, Filho, Jose Teixeira, Oliveira, Celso Luiz Borges de, Roston, Denis Miguel.

Subjects/Keywords: Etinilestradiol; Macrofitas; Aguape; Estrogênios; Cromatografia líquida de alta eficiência; Ethinylestradiol; Macrophytes; Water hyacinth; Estrogens

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Campos, Julyenne Meneghetti, 1. (2014). Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol. (Masters Thesis). Universidade Estadual de Campinas. Retrieved from CAMPOS, Julyenne Meneghetti. Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol. 2014. 225 p. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/257506>. Acesso em: 24 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/257506

Chicago Manual of Style (16^th Edition):

Campos, Julyenne Meneghetti, 1985-. “Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol.” 2014. Masters Thesis, Universidade Estadual de Campinas. Accessed April 15, 2021. CAMPOS, Julyenne Meneghetti. Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol. 2014. 225 p. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/257506>. Acesso em: 24 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/257506.

MLA Handbook (7^th Edition):

Campos, Julyenne Meneghetti, 1985-. “Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol.” 2014. Web. 15 Apr 2021.

Vancouver:

Campos, Julyenne Meneghetti 1. Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol. [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2014. [cited 2021 Apr 15]. Available from: CAMPOS, Julyenne Meneghetti. Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol. 2014. 225 p. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/257506>. Acesso em: 24 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/257506.

Council of Science Editors:

Campos, Julyenne Meneghetti 1. Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol. [Masters Thesis]. Universidade Estadual de Campinas; 2014. Available from: CAMPOS, Julyenne Meneghetti. Eficiência de sistemas de leitos cultivados com Eichhornia crassipes na retenção de poluentes convencionais e o emergente 17-alfa-etinilestradiol. 2014. 225 p. Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agrícola, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/257506>. Acesso em: 24 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/257506

14. Battistin, Thales de Souza [UNIFESP]. Eletroforese capilar para monitoramento ambiental: avaliação das estratégias de pré-concentração on-line e off-line para analisar contaminantes emergentes em efluentes.

Degree: 2019, Universidade Federal de São Paulo

URL: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8175015 ; https://repositorio.unifesp.br/handle/11600/59485

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Contaminantes emergentes são substâncias químicas de ocorrência natural ou antrópica que não tem controle no ambiente e têm condições latentes de ecotoxicidade e efeitos deletérios sobre a saúde humana. Produtos de higiene pessoal, repelentes, medicamentos, inseticidas, entre outros, que chegam aos corpos hídricos de maneira frequente, fazem parte destes contaminantes. O N,N-Dietil-m-toluamida (DEET) e o 3-fenoxibenzil(1RS)-cis,trans-3-(2,2-diclorovinil)-2,2-dimetilciclopropanocarboxilato (permetrina), utilizados como repelente contra insetos e no tratamento da infestação por piolhos, respectivamente, têm sido encontrados em ambientes aquáticos. Ao lado destes, os estrógenos também têm despertado a atenção das agências ambientais, em especial o 17-α-etinilestradiol, que é um hormônio sintético empregado em pílulas anticoncepcionais e considerado um desregulador endócrino. Devido à baixa concentração destes compostos encontrada em água, sua análise tem sido conduzida por técnicas cromatográficas, empregando a detecção por espectrometria de massas, o que gera análises com alto custo e mão de obra especializada. O desenvolvimento de métodos de análise com baixo custo, que propicie a determinação de diferentes classes de contaminantes simultaneamente, com limites de quantificação aceitável, devem ser investigados. Adicionalmente vale destacar que efluentes apresentam alta atividade estrogênica, sendo observada a presença de elevadas concentrações de cafeína, tornando este composto um importante marcador da presença de contaminantes emergentes. Neste sentido, este trabalho teve por finalidade avaliar métodos de pré-concentração on-line e off-line para análise concomitante de DEET, permetrina, 17-α-etinilestradiol e cafeína, empregando como técnicas de analise a eletroforese capilar (CE) e a cromatografia liquida (HPLC) empregando os detectores ultravioleta e de fluorescência. As condições otimizadas para o HPLC foram: coluna C18, fase móvel ACN/H2O com um gradiente na proporção 45:55 (v/v) até 8 min, seguida de 95:5 (v/v) até 18 min, vazão de 1 mL min-1 e temperatura de 25 ± 2ºC em 220 nm por UV e ex= 280 nm e em= 310 nm por fluorescência. Para a CE, a separação para a cafeína, DEET e permetrina, foi obtida empregando o modo de cromatografia eletrocinética micelar (MEKC). A separação foi conduzida em tampão contendo 30 mmol L-1 tetraborato de sódio e 40 mmol L-1 de SDS, pH 9,2; injeção hidrodinâmica (0,5 psi por 5s); temperatura de 25ºC e 15 kV de tensão. Ambos os métodos em HPLC e em CE foram eficientes, separando os compostos e ainda os dois isômeros da permetrina em menos de 20 min. Como estratégia de pré-concentração off-line foi avaliada a microextração liquido-liquido dispersiva (DLLME) empregando como solvente extrator clorofórmio e como…

Advisors/Committee Members: Universidade Federal de São Paulo (UNIFESP), Moraes, Maria de Lourdes Leite de [UNIFESP].

Subjects/Keywords: DEET; Permetrina; 17α-Etinilestradiol; Cafeína; Monitoramento; DEET; Permethrin; 17α-Ethinylestradiol; Caffeine; Monitoring

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Battistin, T. d. S. [. (2019). Eletroforese capilar para monitoramento ambiental: avaliação das estratégias de pré-concentração on-line e off-line para analisar contaminantes emergentes em efluentes. (Masters Thesis). Universidade Federal de São Paulo. Retrieved from https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8175015 ; https://repositorio.unifesp.br/handle/11600/59485

Chicago Manual of Style (16^th Edition):

Battistin, Thales de Souza [UNIFESP]. “Eletroforese capilar para monitoramento ambiental: avaliação das estratégias de pré-concentração on-line e off-line para analisar contaminantes emergentes em efluentes.” 2019. Masters Thesis, Universidade Federal de São Paulo. Accessed April 15, 2021. https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8175015 ; https://repositorio.unifesp.br/handle/11600/59485.

MLA Handbook (7^th Edition):

Battistin, Thales de Souza [UNIFESP]. “Eletroforese capilar para monitoramento ambiental: avaliação das estratégias de pré-concentração on-line e off-line para analisar contaminantes emergentes em efluentes.” 2019. Web. 15 Apr 2021.

Vancouver:

Battistin TdS[. Eletroforese capilar para monitoramento ambiental: avaliação das estratégias de pré-concentração on-line e off-line para analisar contaminantes emergentes em efluentes. [Internet] [Masters thesis]. Universidade Federal de São Paulo; 2019. [cited 2021 Apr 15]. Available from: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8175015 ; https://repositorio.unifesp.br/handle/11600/59485.

Council of Science Editors:

Battistin TdS[. Eletroforese capilar para monitoramento ambiental: avaliação das estratégias de pré-concentração on-line e off-line para analisar contaminantes emergentes em efluentes. [Masters Thesis]. Universidade Federal de São Paulo; 2019. Available from: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=8175015 ; https://repositorio.unifesp.br/handle/11600/59485

15. Gupta, Angel. Synergistic effect of levonorgestrel and ethinylestradiol with some antifertility agents on the reproductive physiology of albino rats; -.

Degree: Zoology, 2000, INFLIBNET

URL: http://shodhganga.inflibnet.ac.in/handle/10603/38232

None

References p. 228-261

Advisors/Committee Members: Bhide, Mangla.

Subjects/Keywords: Albino Rats; Ethinylestradiol; Levonorgestrel; Physiology; Rats; Synergistic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gupta, A. (2000). Synergistic effect of levonorgestrel and ethinylestradiol with some antifertility agents on the reproductive physiology of albino rats; -. (Thesis). INFLIBNET. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/38232

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gupta, Angel. “Synergistic effect of levonorgestrel and ethinylestradiol with some antifertility agents on the reproductive physiology of albino rats; -.” 2000. Thesis, INFLIBNET. Accessed April 15, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/38232.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gupta, Angel. “Synergistic effect of levonorgestrel and ethinylestradiol with some antifertility agents on the reproductive physiology of albino rats; -.” 2000. Web. 15 Apr 2021.

Vancouver:

Gupta A. Synergistic effect of levonorgestrel and ethinylestradiol with some antifertility agents on the reproductive physiology of albino rats; -. [Internet] [Thesis]. INFLIBNET; 2000. [cited 2021 Apr 15]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38232.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gupta A. Synergistic effect of levonorgestrel and ethinylestradiol with some antifertility agents on the reproductive physiology of albino rats; -. [Thesis]. INFLIBNET; 2000. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38232

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Exeter

16. Al-Jandal, Noura. The effects of estrogenic endocrine disruptors on the osmoregulatory functions in euryhaline fish.

Degree: PhD, 2011, University of Exeter

URL: https://ore.exeter.ac.uk/repository/handle/10036/3131 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537841

► Osmoregulation is an essential process to maintain water and ionic balance and when euryhaline fish move between freshwater and seawater environments as part of their… (more)

Subjects/Keywords: 577.27; Endocrine disruptor; Ethinylestradiol; Nonylphenol; Divalent; Osmoregulation; Estrogen; Estradiol; Monovalent; Ion regulation; Water balance; Euryhaline; Salinity challenge; Calcification; Intestine; Marine teleost

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Al-Jandal, N. (2011). The effects of estrogenic endocrine disruptors on the osmoregulatory functions in euryhaline fish. (Doctoral Dissertation). University of Exeter. Retrieved from https://ore.exeter.ac.uk/repository/handle/10036/3131 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537841

Chicago Manual of Style (16^th Edition):

Al-Jandal, Noura. “The effects of estrogenic endocrine disruptors on the osmoregulatory functions in euryhaline fish.” 2011. Doctoral Dissertation, University of Exeter. Accessed April 15, 2021. https://ore.exeter.ac.uk/repository/handle/10036/3131 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537841.

MLA Handbook (7^th Edition):

Al-Jandal, Noura. “The effects of estrogenic endocrine disruptors on the osmoregulatory functions in euryhaline fish.” 2011. Web. 15 Apr 2021.

Vancouver:

Al-Jandal N. The effects of estrogenic endocrine disruptors on the osmoregulatory functions in euryhaline fish. [Internet] [Doctoral dissertation]. University of Exeter; 2011. [cited 2021 Apr 15]. Available from: https://ore.exeter.ac.uk/repository/handle/10036/3131 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537841.

Council of Science Editors:

Al-Jandal N. The effects of estrogenic endocrine disruptors on the osmoregulatory functions in euryhaline fish. [Doctoral Dissertation]. University of Exeter; 2011. Available from: https://ore.exeter.ac.uk/repository/handle/10036/3131 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537841

University of Lund

17. Hallgren, Per. Aquatic organisms on the pill - effects on different organizational levels.

Degree: 2014, University of Lund

URL: https://lup.lub.lu.se/record/4353683 ; https://portal.research.lu.se/ws/files/5620003/4353957.pdf

► Communities are composed of organisms that interact with each other and with the non-biological environment. There are also anthropogenic pollutants in the environment that also… (more)

Subjects/Keywords: Ecology; EDC; EE2; 17α-ethinylestradiol; fish; zooplankton; gastropods; population growth rates; direct and indirect effects; somatic growth; invertebrates

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hallgren, P. (2014). Aquatic organisms on the pill - effects on different organizational levels. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/4353683 ; https://portal.research.lu.se/ws/files/5620003/4353957.pdf

Chicago Manual of Style (16^th Edition):

Hallgren, Per. “Aquatic organisms on the pill - effects on different organizational levels.” 2014. Doctoral Dissertation, University of Lund. Accessed April 15, 2021. https://lup.lub.lu.se/record/4353683 ; https://portal.research.lu.se/ws/files/5620003/4353957.pdf.

MLA Handbook (7^th Edition):

Hallgren, Per. “Aquatic organisms on the pill - effects on different organizational levels.” 2014. Web. 15 Apr 2021.

Vancouver:

Hallgren P. Aquatic organisms on the pill - effects on different organizational levels. [Internet] [Doctoral dissertation]. University of Lund; 2014. [cited 2021 Apr 15]. Available from: https://lup.lub.lu.se/record/4353683 ; https://portal.research.lu.se/ws/files/5620003/4353957.pdf.

Council of Science Editors:

Hallgren P. Aquatic organisms on the pill - effects on different organizational levels. [Doctoral Dissertation]. University of Lund; 2014. Available from: https://lup.lub.lu.se/record/4353683 ; https://portal.research.lu.se/ws/files/5620003/4353957.pdf

18. Lacerda, Monike Fabiane Alves Ribeiro. Degradação de hormônio sintético por meio de lacases fúngicas imobilizadas em fibras de Luffa cylindrica.

Degree: 2015, Universidade Federal de Goiás; Programa de Pós-graduação em Engenharia do Meio Ambiente (EEC); UFG; Brasil; Escola de Engenharia Civil – EEC (RG)

URL: http://repositorio.bc.ufg.br/tede/handle/tede/5170

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Made available in DSpace on 2016-01-29T13:41:34Z (GMT). No. of bitstreams: 2 Dissertação - Monike Fabiane Alves Ribeiro Lacerda - 2015.pdf: 2186149 bytes, checksum: 3cc547d5ad7e335bd22528c5658d79f5 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2015-09-24

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES

The 17α-ethinylestradiol (EE2) is a synthetic estrogen used in contraceptive and hormone replacement therapies; is an environmental contaminant potential, it is not completely removed in sewage treatment plants, reaching the aquatic environment, with the aggravating factor interfere the endocrine system of humans and other animals. For this reason there is great interest in the removal of EE2 present in wastewater, surface water and groundwater. Thus the use of laccase for this purpose may be promising because of low specificity of this enzyme to the substrate. Therefore, the aim of this study was to evaluate the effectiveness of laccase produced by the fungus Pleurotus ostreatus immobilized in Luffa cylindrica (loofah) fibers in EE2 degradation. Therefore the best means for production of laccase and the best conditions of pH and temperature were investigated. The immobilization process was realized and removal of the EE2 assay was conducted in flasks and in a batch reactor. Thus, the best means for producing laccase were Potato Dextrose and Potato Dextrose Modified with guariroba straw. Readings taken with 2.2-Azino-bis (3-ethylbenzothializone-6-sulfonic acid) - ABTS revealed best pH between 3.6 and 4.6 and optimal band temperature between 30 and 50 °C for free and immobilized enzymes. The laccase produced in both media had an apparent molecular mass of 40 kDa. The best conditions found for the immobilization process were glutaraldehyde concentration of 2% and reaction with the support 1 hour under stirring (120 rpm); drying the loofah prior to the reaction with glutaraldehyde; time of 24 hours of immobilization. The immobilized enzyme showed best enzymatic activity in alkaline pH, and at higher temperatures, compared to the free enzyme. The operational stability, storage and thermostability were not significant. Best removals for tests in flasks were 79.22% and 75.0% for free and immobilized enzyme, respectively. As the tests carried out in the reactor showed removal by adsorption of 99.3%…

Advisors/Committee Members: Santiago, Mariângela Fontes, Lopes, Flávio Marques, Santiago, Mariângela Fontes, Siqueira, Eduardo Queija de, Schimidt, Fernando.

Subjects/Keywords: Etinilestradiol; Enzima lignolítica; Pleurotus ostreatus; Fibras lignocelulósicas; Bucha vegetal; Ethinylestradiol; Lignolytic enzyme; Pleurotus ostreatus; Lignocellulosic fibers; Loofah; ENGENHARIAS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lacerda, M. F. A. R. (2015). Degradação de hormônio sintético por meio de lacases fúngicas imobilizadas em fibras de Luffa cylindrica. (Masters Thesis). Universidade Federal de Goiás; Programa de Pós-graduação em Engenharia do Meio Ambiente (EEC); UFG; Brasil; Escola de Engenharia Civil – EEC (RG). Retrieved from http://repositorio.bc.ufg.br/tede/handle/tede/5170

Chicago Manual of Style (16^th Edition):

Lacerda, Monike Fabiane Alves Ribeiro. “Degradação de hormônio sintético por meio de lacases fúngicas imobilizadas em fibras de Luffa cylindrica.” 2015. Masters Thesis, Universidade Federal de Goiás; Programa de Pós-graduação em Engenharia do Meio Ambiente (EEC); UFG; Brasil; Escola de Engenharia Civil – EEC (RG). Accessed April 15, 2021. http://repositorio.bc.ufg.br/tede/handle/tede/5170.

MLA Handbook (7^th Edition):

Lacerda, Monike Fabiane Alves Ribeiro. “Degradação de hormônio sintético por meio de lacases fúngicas imobilizadas em fibras de Luffa cylindrica.” 2015. Web. 15 Apr 2021.

Vancouver:

Lacerda MFAR. Degradação de hormônio sintético por meio de lacases fúngicas imobilizadas em fibras de Luffa cylindrica. [Internet] [Masters thesis]. Universidade Federal de Goiás; Programa de Pós-graduação em Engenharia do Meio Ambiente (EEC); UFG; Brasil; Escola de Engenharia Civil – EEC (RG); 2015. [cited 2021 Apr 15]. Available from: http://repositorio.bc.ufg.br/tede/handle/tede/5170.

Council of Science Editors:

Lacerda MFAR. Degradação de hormônio sintético por meio de lacases fúngicas imobilizadas em fibras de Luffa cylindrica. [Masters Thesis]. Universidade Federal de Goiás; Programa de Pós-graduação em Engenharia do Meio Ambiente (EEC); UFG; Brasil; Escola de Engenharia Civil – EEC (RG); 2015. Available from: http://repositorio.bc.ufg.br/tede/handle/tede/5170

19. Guilherme Casoni da Rocha. Avaliação da atividade estrogênica das águas do Rio Paraíba do Sul.

Degree: 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/18/18139/tde-01032013-081607/

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A poluição da água doce no estado de São Paulo ocorre por diversas causas. Entre elas está a ineficiência do serviço de tratamento de esgoto… (more)

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A poluição da água doce no estado de São Paulo ocorre por diversas causas. Entre elas está a ineficiência do serviço de tratamento de esgoto sanitário. Alguns componentes do esgoto sanitário são desreguladores endócrinos, entre eles estão os hormônios naturais e sintéticos excretados pelos seres humanos. Estas substâncias causam modificações no sistema reprodutivo como, por exemplo, câncer, feminização, alterações na transcrição genética, alteração nas gônadas, indução à síntese de vitelogenina, entre outros. O objetivo desse trabalho foi testar a atividade endócrina das águas do rio Paraíba do Sul, em Pindamonhangaba, SP. Para tanto, amostras de água do rio foram utilizadas para a quantificação dos hormônios, 17-etinilestradiol, 17-estradiol e levonorgestrel por meio da técnica de cromatografia líquida de alta eficiência (HPLC). Além disso, foram realizados testes crônicos com peixes (Danio rerio) no interior do rio e em laboratório, e uma posterior quantificação de vitelogenina. Os resultados não indicaram concentrações detectáveis dos hormônios pelo método empregado. Entretanto, foi detectada a indução de vitelogenina nos machos de Danio rerio. Esse fato indica a atividade estrogênica da água utilizada. São necessários outros estudos para a avaliação de quais substâncias presentes na água, estão causando as alterações endócrinas nos peixes, entre eles a utilização de índices para priorizar o local inicial dessas pesquisas. Esses estudos são importantes para a conservação da biodiversidade aquática do rio Paraíba do Sul

Freshwater pollution in São Paulo state, Brazil, occurs due a several reasons. Among them there is the inefficiency of the sewage treatment service. Some sewage components are endocrine disrupters, including natural and synthetic hormones excreted by humans. These substances cause modification on reproductive system such as cancer, feminization, gene transcription and gonad alterations, vitellogenin synthesis induction, among others. The aim of this work was to evaluate the endocrine activity of the river Paraíba do Sul, at Pindamonhangaba city, Brazil. For this, river water samples were collected for the quantification of the hormones, 17- etinylestradiol, 17-estradiol and levonorgestrel by high performance liquid chromatography (HPLC). Furthermore, chronic assays were performed with fish (Danio rerio) into the river and in the laboratory, following quantification of biomarker vitellogenin. The studied hormones were not detected by employed methods. However, induction of vitellogenin in male of Danio rerio was detected indicating estrogenic activity of water. Further studies are necessary for the assessment of which substances into the water are causing the endocrine disruption in fish. These studies are important for the preservation of aquatic biodiversity of the Paraiba do Sul River

Advisors/Committee Members: Eny Maria Vieira, Silvia Helena Govoni Brondi, Sandro Xavier de Campos, Luiz Antonio Daniel, Ricardo Luvizotto Santos.

Subjects/Keywords: 17-estradiol; 17-etinilestradiol; Danio rerio; Levonorgestrel; Vitelogenina.; 17-estradiol; 17-ethinylestradiol; Danio rerio; Hormone; Levonorgestrel; Vitellogenin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rocha, G. C. d. (2012). Avaliação da atividade estrogênica das águas do Rio Paraíba do Sul. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/18/18139/tde-01032013-081607/

Chicago Manual of Style (16^th Edition):

Rocha, Guilherme Casoni da. “Avaliação da atividade estrogênica das águas do Rio Paraíba do Sul.” 2012. Doctoral Dissertation, University of São Paulo. Accessed April 15, 2021. http://www.teses.usp.br/teses/disponiveis/18/18139/tde-01032013-081607/.

MLA Handbook (7^th Edition):

Rocha, Guilherme Casoni da. “Avaliação da atividade estrogênica das águas do Rio Paraíba do Sul.” 2012. Web. 15 Apr 2021.

Vancouver:

Rocha GCd. Avaliação da atividade estrogênica das águas do Rio Paraíba do Sul. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Apr 15]. Available from: http://www.teses.usp.br/teses/disponiveis/18/18139/tde-01032013-081607/.

Council of Science Editors:

Rocha GCd. Avaliação da atividade estrogênica das águas do Rio Paraíba do Sul. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/18/18139/tde-01032013-081607/

20. Viviane Benevenuti Silva. Determinação simultânea de etinilestradiol e drospirenona em contraceptivos orais por cromatografia e fase líquida de alta eficiência e eletroforese capilar.

Degree: 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/9/9139/tde-05092013-102602/

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O controle da fertilidade é obtido principalmente pela inibição da ovulação por meio da atividade combinada de dois componentes principais: estrogênio e progestina. Desta forma,… (more)

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O controle da fertilidade é obtido principalmente pela inibição da ovulação por meio da atividade combinada de dois componentes principais: estrogênio e progestina. Desta forma, novas formulações vêm sendo desenvolvidas com baixa dose de etinilestradiol associado a um novo agente progestógeno, a drospirenona, com o objetivo de garantir equilíbrio entre eficácia, segurança e controle de ciclo menstrual. Este trabalho tem como objetivo desenvolver, validar e comparar métodos analíticos para a identificação e quantificação de etinilestardiol e drospirenona presentes em uma mesma formulação por cromatografia em fase líquida de alta eficiência (CLAE) e a eletroforese capilar (EC). O método por CLAE, foi realizado empregando-se uma coluna LiChoCART® 100RP - C18, (125 x 4 mm) 5 µm, fase móvel constituída por MeCN/H2O 50:50 (v/v) e vazão de 1.0 mL min. Utilizou-se um detector UV 200 nm para drospirenona e um de fluorescência λex = 280 nm e λem = 310 nm, para o etinilestradiol. O método por EC foi validado utilizando-se como eletrólito, tampão de tetraborato de sódio 30 mM, dodecil sulfato de sódio 20 mM e acetonitrila 30% a pH 9,2, capilar de sílica fundida de 31,2 cm sendo 21 cm efetivos, com 75 µm de diâmetro interno. O método por CLAE apresentou um coeficiente de correlação (r2) de 0,9989 para o etinilestradiol e 0,999 para a drospirenona. No método por EC, o coeficiente de correlação (r2) encontrado foi de 0,9988 para o etinilestradiol e 0,998 para a drospirenona. Os métodos podem ser considerados eficientes e confiáveis para serem empregados em análise de rotina para controle de qualidade destes produtos farmacêuticos.

The fertility control is achieved mainly by inhibiting ovulation through the combined activity of two main components: estrogen and progestin. Thus, new formulations have been developed associating appropriately low dose of ethinylestradiol to a new drug, the drospirenone, in order to ensure the balance between efficacy, safety and cycle control. The objective of this research was to develop, to validate and to compare two analytical method for separation and quantification of ethinylestardiol and drospirenone using high performance liquid chromatography and capillary electrophoresis (CE). The HPLC method, was performed using a LiChoCART® 100RP - C18, (125 x 4 mm) 5 µm column, a mobile phase constituted of acetonitrile:water (50:50 v/v) and flow rate of 1.0 mL min. UV detection was made for drospirenone at 200 nm coupled with a fluorescence detector at λex= 280 nm and λem = 310 nm for ethinylestradiol. The CE method was validated using a solution of sodium tetraborate buffer 30 mM, sodium dodecil sulphate 20 mM and acetonitrile 30%, pH 9.2 and a fused silica capillary of 31,2 cm with 21 cm effective and 75 µm of diameter. The HPLC method showed a correlation coefficient (r2) of 0.9989 for ethinylestradiol and 0,999 for drospirenone. For CE method, the correlation coefficient was (r2) 0,9988 for ethinylestradiol and 0,9989 for drospirenone. The methods…

Advisors/Committee Members: Maria Ines Rocha Miritello Santoro, Lucildes Pita Mercuri, Eliane Maria de Almeida Orsine.

Subjects/Keywords: Cromatografia líquida de alta eficiência; Drospirenona; Eletroforese capilar; Etinilestradiol; Métodos analíticos; Analytical methods; Capillary electrophoresis; Drospirenone; Ethinylestradiol; High performance liquid chromatography

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, V. B. (2012). Determinação simultânea de etinilestradiol e drospirenona em contraceptivos orais por cromatografia e fase líquida de alta eficiência e eletroforese capilar. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/9/9139/tde-05092013-102602/

Chicago Manual of Style (16^th Edition):

Silva, Viviane Benevenuti. “Determinação simultânea de etinilestradiol e drospirenona em contraceptivos orais por cromatografia e fase líquida de alta eficiência e eletroforese capilar.” 2012. Masters Thesis, University of São Paulo. Accessed April 15, 2021. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-05092013-102602/.

MLA Handbook (7^th Edition):

Silva, Viviane Benevenuti. “Determinação simultânea de etinilestradiol e drospirenona em contraceptivos orais por cromatografia e fase líquida de alta eficiência e eletroforese capilar.” 2012. Web. 15 Apr 2021.

Vancouver:

Silva VB. Determinação simultânea de etinilestradiol e drospirenona em contraceptivos orais por cromatografia e fase líquida de alta eficiência e eletroforese capilar. [Internet] [Masters thesis]. University of São Paulo; 2012. [cited 2021 Apr 15]. Available from: http://www.teses.usp.br/teses/disponiveis/9/9139/tde-05092013-102602/.

Council of Science Editors:

Silva VB. Determinação simultânea de etinilestradiol e drospirenona em contraceptivos orais por cromatografia e fase líquida de alta eficiência e eletroforese capilar. [Masters Thesis]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/9/9139/tde-05092013-102602/

21. Emerson Jeronymo Eduardo. Estudo da degradação eletroquímica, fotolítica, fotocatalítica e eletrofotocatalítica do hormônio etinilestradiol.

Degree: 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/75/75131/tde-10032010-095240/

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Nos últimos anos, a pesquisa ambiental tem se defrontado com sérios problemas em relação a algumas substâncias presentes no meio aquático em pequenas concentrações. Os… (more)

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Nos últimos anos, a pesquisa ambiental tem se defrontado com sérios problemas em relação a algumas substâncias presentes no meio aquático em pequenas concentrações. Os desruptores endócrinos tais como produtos farmacêuticos, hormônios naturais e sintéticos, pesticidas, substancias tensosativas, polímeros de baixa massa molar e diversos outros contaminantes orgânicos presentes em efluentes municipais e industriais, são exemplos dessas substancias que contribuem para alterar o funcionamento do sistema endócrino. Varias técnicas já foram empregadas na degradação dessas substancias contida no meio aquático, mas não se demonstraram eficazes.Este trabalho tem por objetivo estudar a degradação do Hormônio etinilestradiol que é um agente terapêutico e um método contraceptivo muito usado. É preocupante o crescente uso desta substância, pois é encontrada no meio aquático de várias partes do mundo.Para a degradação do hormônio etinilestadiol testou!se quatro técnicas de degradação, (a) eletrólise, (b) fotólise, (c) fotocatálise e (d) eletrofotocatálise.O eletrodo de trabalho utilizado foi de carbono vítreo em meio de KCl para a eletrólise. Como catalisador utilizou!se o Ti/TiO2 na fotocatálise e foteletrocatálise. Os processos degradativos foram acompanhados por espectroscopia UV-vis e cromatografia HPLC.Foram feitos testes de identificação da formação de clorato e hipoclorito nas amostras finais, pois estas espécies podem auxiliar na degradação de substâncias orgânica nos processos eletroquímicos e fotoquímicos.

In recent years, the environmental research has been facing serious problems in relation to some substances in the aquatic environment in small concentrations, such as the endocrine desruptores pharmaceuticals, natural and synthetic hormones, pesticides, tensosativas substances, polymers of low molar mass and different other organic contaminants present in municipal and industrial effluents, are examples of substances that contribute to change and the functioning of the endocrine system. Several techniques have been used for the degradation of these substances in the aquatic environment, but none demonstrated effectiveness.This work aimed to study the degradation of the hormone ethinyl estradiol which is a therapeutic agent and is widely used in contraceptive method. It is worrying the increasing use of this substance because it is found in various parts of the world.It was tested four techniques of degradation of the hormone, (a) electrolysis, (b) photolysis, (c) photocatalysis and (d) photoelectrocatalysis. The working electrode of glassy carbon was used in KCl medium for electrolysis. As catalyst, was used Ti/TiO2 in the photocatalysis and photoelectrocatalysis. The degradation process was followed by UV-vis spectroscopy and HPLC chromatography.It was carried out tests to identify the formation of chlorate and hypochlorite in the samples once these species can help the degradation in electrochemical and photochemical process.

Advisors/Committee Members: Germano Tremiliosi Filho, Eduardo Bessa Azevedo, Geoffroy Roger Pointer-Malpass.

Subjects/Keywords: Degradação; Eletroquímica; Etinilestradiol; Fotoquímica; Degradation; Electrochemical; Ethinylestradiol; Photochemical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Eduardo, E. J. (2009). Estudo da degradação eletroquímica, fotolítica, fotocatalítica e eletrofotocatalítica do hormônio etinilestradiol. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/75/75131/tde-10032010-095240/

Chicago Manual of Style (16^th Edition):

Eduardo, Emerson Jeronymo. “Estudo da degradação eletroquímica, fotolítica, fotocatalítica e eletrofotocatalítica do hormônio etinilestradiol.” 2009. Masters Thesis, University of São Paulo. Accessed April 15, 2021. http://www.teses.usp.br/teses/disponiveis/75/75131/tde-10032010-095240/.

MLA Handbook (7^th Edition):

Eduardo, Emerson Jeronymo. “Estudo da degradação eletroquímica, fotolítica, fotocatalítica e eletrofotocatalítica do hormônio etinilestradiol.” 2009. Web. 15 Apr 2021.

Vancouver:

Eduardo EJ. Estudo da degradação eletroquímica, fotolítica, fotocatalítica e eletrofotocatalítica do hormônio etinilestradiol. [Internet] [Masters thesis]. University of São Paulo; 2009. [cited 2021 Apr 15]. Available from: http://www.teses.usp.br/teses/disponiveis/75/75131/tde-10032010-095240/.

Council of Science Editors:

Eduardo EJ. Estudo da degradação eletroquímica, fotolítica, fotocatalítica e eletrofotocatalítica do hormônio etinilestradiol. [Masters Thesis]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/75/75131/tde-10032010-095240/

22. Cunha, Danieli Lima da. Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ.

Degree: 2014, Brazil

URL: https://www.arca.fiocruz.br/handle/icict/36189

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Submitted by Repositório Arca ([email protected]) on 2019-09-10T12:54:56Z No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) danieli_lima_da.pdf: 1769147 bytes, checksum: 2f54249e4b0c729f79240eba4aa1856a (MD5)

Approved for… (more)

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Submitted by Repositório Arca ([email protected]) on 2019-09-10T12:54:56Z No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) danieli_lima_da.pdf: 1769147 bytes, checksum: 2f54249e4b0c729f79240eba4aa1856a (MD5)

Approved for entry into archive by Erasmo Martins ([email protected]) on 2019-10-04T15:48:55Z (GMT) No. of bitstreams: 2 danieli_lima_da.pdf: 1769147 bytes, checksum: 2f54249e4b0c729f79240eba4aa1856a (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5)

Made available in DSpace on 2019-10-04T15:48:55Z (GMT). No. of bitstreams: 2 danieli_lima_da.pdf: 1769147 bytes, checksum: 2f54249e4b0c729f79240eba4aa1856a (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2014

Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.

A presença no meio hídrico de contaminantes orgânicos com atividade estrogênica é um tema que tem gerado crescente preocupação na comunidade científica, uma vez que tais contaminantes são capazes de desencadear efeitos adversos no sistema endócrino de várias espécies. O estrogênio sintético 17α-etinilestradiol (principal componente utilizado em formulações de contraceptivos orais) tem sido apontado como um dos principais compostos responsáveis por provocar tais alterações. O principal objetivo deste estudo foi investigar, através de um questionário, o padrão de consumo do 17α-etinilestradiol presente em contraceptivos orais e medicamentos utilizados na TRH feminina, e estimar o aporte deste estrogênio nos corpos hídricos da área urbana do 1° distrito do município de Santa Maria Madalena. Para o desenvolvimento deste trabalho utilizou-se como metodologia um estudo do tipo inquérito realizado com 325 mulheres de 15 a 59 anos de idade, residentes na área de estudo, no período de setembro a dezembro do ano de 2013. Das 325 mulheres entrevistadas, constatou-se que 95 fazem o uso de contraceptivo oral, sendo que destas, 91 fazem uso de formulações que contêm o 17α-etinilestradiol. Tomando a amostra (N=325) como estatisticamente representativa da área de estudo, pôde-se extrapolar o valor de consumo do 17 α-etinilestradiol para a população total de mulheres (N=2054) na faixa etária estabelecida. Com base nas informações obtidas a partir da elaboração do presente estudo foi possível estimar que há um considerável aporte desta substância nos corpos hídricos da área urbana do 1° distrito do município de Santa Maria Madalena (16 mg/dia), o que sugere a possibilidade de efeitos adversos à biota aquática local. Uma vez que o presente estudo não encerra a discussão sobre o assunto, ao fim desta dissertação há uma proposição para um trabalho futuro no sentido de se avançar neste tema.

The presence of organic contaminants with estrogenic activity in aquatic environment is a topic with growing concern in scientific community, since those contaminants are capable or triggering adverse…

Advisors/Committee Members: Larentis, Ariane Leites, Sarcinelli, Paula de Novaes.

Subjects/Keywords: Etinilestradiol; Contraceptivos Orais; Poluição da Água; Ecotoxicologia; Ethinylestradiol; Oral Contraceptives; Water Pollution; Ecotoxicology; Etinilestradiol; Anticoncepcionais Orais; Ecotoxicologia; Poluição da Água

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cunha, D. L. d. (2014). Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ. (Masters Thesis). Brazil. Retrieved from https://www.arca.fiocruz.br/handle/icict/36189

Chicago Manual of Style (16^th Edition):

Cunha, Danieli Lima da. “Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ.” 2014. Masters Thesis, Brazil. Accessed April 15, 2021. https://www.arca.fiocruz.br/handle/icict/36189.

MLA Handbook (7^th Edition):

Cunha, Danieli Lima da. “Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ.” 2014. Web. 15 Apr 2021.

Vancouver:

Cunha DLd. Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ. [Internet] [Masters thesis]. Brazil; 2014. [cited 2021 Apr 15]. Available from: https://www.arca.fiocruz.br/handle/icict/36189.

Council of Science Editors:

Cunha DLd. Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ. [Masters Thesis]. Brazil; 2014. Available from: https://www.arca.fiocruz.br/handle/icict/36189

Universidade do Estado do Rio de Janeiro

23. Marcio de Miranda Oliveira. Monitoramento de desreguladores endócrinos no rio Arroio Fundo na bacia de Jacarepaguá, RJ.

Degree: Master, 2015, Universidade do Estado do Rio de Janeiro

URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9024 ;

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Os desreguladores endócrinos são compostos micropoluentes de ação deletéria que causam efeitos aos animais e aos seres humanos. Estes vêm trazendo a várias décadas, problemas… (more)

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Os desreguladores endócrinos são compostos micropoluentes de ação deletéria que causam efeitos aos animais e aos seres humanos. Estes vêm trazendo a várias décadas, problemas relacionados à má formação ou ainda infertilidade de várias espécies. A presença destes compostos na ordem de ng L-1 já é capaz de gerar efeitos nocivos ao sistema endócrino. Este trabalho visou à determinação da presença e quantidade de alguns destes compostos como 17α-etinilestradiol, bisfenol A e estrona entre outros, nas águas do rio Arroio Fundo, localizado em Jacarepaguá no RJ que possui um índice de qualidade de água ruim. A primeira etapa deste trabalho foi a implementação e validação de metodologia para determinação do 17α-etinilestradiol por cromatografia líquida acoplada a detector de fluorescência onde foram estabelecido limite de detecção, de quantificação e linearidade conforme orientação do Inmetro (2010). Além da avaliação das amostras ambientais através da metodologia estabelecida. Na etapa subsequente foram realizados os experimentos relativos à determinação dos desreguladores endócrinos através da espectrometria de massas por detector tipo tandem quadrupolo, onde também foram realizados os procedimentos de validação e determinação dos compostos bisfenol A e estrona que não foram suscetíveis a efeito de matriz durante a ionização, que acabou impedindo a determinação de outros desreguladores endócrinos. Os resultados indicam que não há redução da presença dos desreguladores endócrinos detectados, e de outros compostos orgânicos também detectados, mas não identificados, entre os pontos a montante e a jusante da Unidade de Tratamento do Rio Arroio Fundo. Todavia em função do grande efeito de matriz oriundo do fato da amostra ser de extrema complexidade, não foi possível realizar uma identificação e quantificação de todos os compostos alvos.

Endocrine disrupters are compounds micropollutants of deleterious effects that cause effects to animals and humans has brought these problems to several decades related to poor training or infertility of various species. The presence of these compounds in the ng L-1 order is already capable of generating negative effects on the endocrine system. This work aimed at determining the presence and amount of some of these compounds as 17α-ethinylestradiol, bisphenol A and estrone among others, in the waters of the river Arroio Fundo, located in Jacarepaguá in Rio de Janeiro that has a bad water quality index. The first stage of this work was the implementation and validation of a method for determination of 17α-ethinylestradiol by liquid chromatography-fluorescence detection which were established limit of detection, quantification and linearity as directed by Inmetro (2010). Besides the evaluation of the samples through the established methodology. In subsequent step were carried out experiments on the determination of endocrine disruptors by tandem quadrupole mass spectrometry detector, were being performed validation procedures and determination of the compounds bisphenol A…

Advisors/Committee Members: Daniele Maia Bila, Eduardo Monteiro Martins, Alexsandro Araújo da Silva, Glauco Favilla Bauerfeldt, Simone Carvalho Chiapetta.

Subjects/Keywords: Engenharia Ambiental; Desreguladores Endócrinos; Bisfenol A; 17α; -Etinilestradiol; Cromatografia Líquida; Espectrometria de Massas; Environmental Engineering; Endocrine disrupters; Bisphenol A; 17α; -Ethinylestradiol; Liquid Cromatography; Mass Spectrometry; ENGENHARIAS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oliveira, M. d. M. (2015). Monitoramento de desreguladores endócrinos no rio Arroio Fundo na bacia de Jacarepaguá, RJ. (Masters Thesis). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9024 ;

Chicago Manual of Style (16^th Edition):

Oliveira, Marcio de Miranda. “Monitoramento de desreguladores endócrinos no rio Arroio Fundo na bacia de Jacarepaguá, RJ.” 2015. Masters Thesis, Universidade do Estado do Rio de Janeiro. Accessed April 15, 2021. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9024 ;.

MLA Handbook (7^th Edition):

Oliveira, Marcio de Miranda. “Monitoramento de desreguladores endócrinos no rio Arroio Fundo na bacia de Jacarepaguá, RJ.” 2015. Web. 15 Apr 2021.

Vancouver:

Oliveira MdM. Monitoramento de desreguladores endócrinos no rio Arroio Fundo na bacia de Jacarepaguá, RJ. [Internet] [Masters thesis]. Universidade do Estado do Rio de Janeiro; 2015. [cited 2021 Apr 15]. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9024 ;.

Council of Science Editors:

Oliveira MdM. Monitoramento de desreguladores endócrinos no rio Arroio Fundo na bacia de Jacarepaguá, RJ. [Masters Thesis]. Universidade do Estado do Rio de Janeiro; 2015. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=9024 ;

Virginia Tech

24. Khunjar, Wendell O'Neil. Elucidating Factors that Impact the Removal of Organic Microconstituents by Ammonia Oxidizing and Heterotrophic Bacteria.

Degree: PhD, Civil Engineering, 2009, Virginia Tech

URL: http://hdl.handle.net/10919/77303

► Although wastewater treatment plants are a line of defense in minimizing indiscriminate output of microconstituents to natural waters, we do not possess a fundamental understanding… (more)

▼ Although wastewater treatment plants are a line of defense in minimizing indiscriminate output of microconstituents to natural waters, we do not possess a fundamental understanding of the mechanisms involved in microconstituent removal during wastewater treatment. With this in mind, experiments were designed to investigate the factors that can influence the fate of four microconstituents, carbamazepine (CBZ), 17alpha-ethinylestradiol (EE2), iopromide (IOP), and trimethoprim (TMP), during biological suspended culture treatment. Specifically, the role that various ecological members of biological treatment systems play in biotransforming these compounds was evaluated. Sorption assays were performed with inactivated biomass samples (ammonia oxidizing bacteria (AOB), laboratory enriched heterotrophic cultures free of active nitrifiers with low (Ox⁻) or high (Ox⁺) oxygenase activity, and a nitrifying activated sludge (NAS) from a full-scale wastewater treatment plant) to determine whether partitioning dictates removal of individual microconstituents. No microconstituents sorbed to the AOB culture. Neither CBZ nor IOP sorbed to Ox⁻, Ox⁺ and NAS cultures; however, EE2 and TMP sorbed to the Ox⁻, Ox⁺ and NAS biomass. Sorption was positively influenced by the presence of exopolymeric substances (EPS) associated with the cultures. The protein content of EPS affected EE2 and TMP sorption more appreciably than the polysaccharide content of EPS. Further experiments were performed to investigate microconstituent biodegradation by AOBs, Ox⁻ and Ox⁺ cultures. The influence of growth state and oxygenase activity on biotransformation by each culture was also evaluated. Results indicate that EE2 was the only microconstituent that was amenable to biotransformation by batch cultured AOB and heterotrophic cultures. EE2 was biotransformed but not mineralized by AOB chemostat and batch cultures. TMP was not transformed by AOB batch or chemostat cultures; however both EE2 and TMP were transformed by Ox⁻ and Ox⁺ chemostat cultures. Radiolabeled studies showed that EE2 was mineralized by this culture. Kinetically, AOBs dominated EE2 transformation to monohydroxylated metabolites; however, both Ox⁻ and Ox⁺ cultures further degraded and mineralized EE2 and metabolites generated by AOBs. These results indicate that biotransformation of EE2 by NAS may be limited by heterotrophic activity whereas TMP fate may be a function of heterotrophic activity only. Oxygenase activity did not limit EE2 or TMP biotransformation in chemostat cultures. Subsequent experiments that were performed to identify the factors that influence heterotrophic degradation of EE2 and TMP indicated that the presence of readily biodegradable substrates slows EE2 and TMP biotransformation. The impact of slowly biodegradable substrates like EPS on EE2 and TMP degradation was unclear. These results suggest that EE2 and TMP are most amenable to biodegradation in bioreactors where endogenous conditions dominate. Advisors/Committee Members: Love, Nancy G. (committeechair), Aga, Diana (committee member), Harper, Willie F. Jr. (committee member), Little, John C. (committee member), Stevens, Ann M. (committee member), Vikesland, Peter J. (committee member).

Subjects/Keywords: Carbamazepine; Iopromide; 17alpha-ethinylestradiol; Trimethoprim; Sorption; Exopolymeric Substances; Nitrosomonas europaea; Trace organic contaminants.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Khunjar, W. O. (2009). Elucidating Factors that Impact the Removal of Organic Microconstituents by Ammonia Oxidizing and Heterotrophic Bacteria. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77303

Chicago Manual of Style (16^th Edition):

Khunjar, Wendell O'Neil. “Elucidating Factors that Impact the Removal of Organic Microconstituents by Ammonia Oxidizing and Heterotrophic Bacteria.” 2009. Doctoral Dissertation, Virginia Tech. Accessed April 15, 2021. http://hdl.handle.net/10919/77303.

MLA Handbook (7^th Edition):

Khunjar, Wendell O'Neil. “Elucidating Factors that Impact the Removal of Organic Microconstituents by Ammonia Oxidizing and Heterotrophic Bacteria.” 2009. Web. 15 Apr 2021.

Vancouver:

Khunjar WO. Elucidating Factors that Impact the Removal of Organic Microconstituents by Ammonia Oxidizing and Heterotrophic Bacteria. [Internet] [Doctoral dissertation]. Virginia Tech; 2009. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10919/77303.

Council of Science Editors:

Khunjar WO. Elucidating Factors that Impact the Removal of Organic Microconstituents by Ammonia Oxidizing and Heterotrophic Bacteria. [Doctoral Dissertation]. Virginia Tech; 2009. Available from: http://hdl.handle.net/10919/77303

University of Maryland

25. Pollack, Sara. Physiological Responses of the Fathead Minnow (Pimephales promelas) to Anthropogenic Sources of Endocrine Disruptors.

Degree: Marine-Estuarine-Environmental Sciences, 2008, University of Maryland

URL: http://hdl.handle.net/1903/8811

► Anthropogenic sources of endocrine disrupting compounds (EDCs) are prevalent in aquatic ecosystems. As a result, these compounds target the most vulnerable physiological mechanisms of reproductive… (more)

▼ Anthropogenic sources of endocrine disrupting compounds (EDCs) are prevalent in aquatic ecosystems. As a result, these compounds target the most vulnerable physiological mechanisms of reproductive development in fish. The main focus of this study was to assess the impact of two sources of EDCs; a single potent EDC, 17α-ethinylestradiol (EE2), as well as an agricultural source of an EDC mixture, poultry litter leachate, on the reproductive processes of the fathead minnow, Pimephales promelas. The experimental paradigms included a 21-day laboratory reproductive assay, a larval exposure including a depuration step until 8 months of age to determine the response in the adult animal, and a whole-organism, partial life-cycle assessment of reproductively active adult fish and development of their offspring. In the first experiment, breeding groups of fathead minnow were exposed to 0, 10, and 40 ng/L of EE2 for 21 days. A significant decrease in testosterone (T), the 17β-estradiol (E2)/T ratio and 11-ketotestosterone in males was observed in the 10 ng/L and 40 ng/L EE2 treatments compared to the control. Male secondary sex characteristics declined with increasing concentrations of EE2. Moreover, 43% of the males in the highest EE2 group (40 ng/L EE2) developed ovipositors. In experiment two, E2 was detected at approximately 200-400 pg/mL and T at approximately 100-400 pg/mL in the poultry litter leachate. Gender ratio was skewed toward female in the two highest concentrations of the poultry litter leachate treatment groups. In experiment three, with a transgenerational design, adult fish had reduced fecundity and males had a significant reduction in male traits when exposed to poultry litter leachate. Vitellogenin production was observed in male fish. In the offspring, both the Low and E2 fish from the same treated adults had significantly lower GSI values and aromatase activity levels. Exploration of different developmental stages and exposures across generations improves our understanding of the impact anthropogenic EDCs can have on wild fish populations. Advisors/Committee Members: Lamp, William O (advisor).

Subjects/Keywords: Biology, Ecology; Endocrine disruptors; Fathead minnow; Poultry litter; Ethinylestradiol; Transgenerational

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pollack, S. (2008). Physiological Responses of the Fathead Minnow (Pimephales promelas) to Anthropogenic Sources of Endocrine Disruptors. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/8811

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pollack, Sara. “Physiological Responses of the Fathead Minnow (Pimephales promelas) to Anthropogenic Sources of Endocrine Disruptors.” 2008. Thesis, University of Maryland. Accessed April 15, 2021. http://hdl.handle.net/1903/8811.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pollack, Sara. “Physiological Responses of the Fathead Minnow (Pimephales promelas) to Anthropogenic Sources of Endocrine Disruptors.” 2008. Web. 15 Apr 2021.

Vancouver:

Pollack S. Physiological Responses of the Fathead Minnow (Pimephales promelas) to Anthropogenic Sources of Endocrine Disruptors. [Internet] [Thesis]. University of Maryland; 2008. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1903/8811.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pollack S. Physiological Responses of the Fathead Minnow (Pimephales promelas) to Anthropogenic Sources of Endocrine Disruptors. [Thesis]. University of Maryland; 2008. Available from: http://hdl.handle.net/1903/8811

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Cunha, Danieli Lima da. Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ.

Degree: 2014, Brazil

URL: https://www.arca.fiocruz.br/handle/icict/23395

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Approved for… (more)

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Made available in DSpace on 2017-11-27T18:22:44Z (GMT). No. of bitstreams: 2 324.pdf: 1769147 bytes, checksum: 2f54249e4b0c729f79240eba4aa1856a (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2014

Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.

A presença no meio hídrico de contaminantes orgânicos com atividade estrogênica é um tema que tem gerado crescente preocupação na comunidade científica, uma vez que tais contaminantes são capazes de desencadear efeitos adversos no sistema endócrino de várias espécies. O estrogênio sintético 17α-etinilestradiol (principal componente utilizado em formulações de contraceptivos orais) tem sido apontado como um dos principais compostos responsáveis por provocar tais alterações. O principal objetivo deste estudo foi investigar, através de um questionário, o padrão de consumo do 17α-etinilestradiol presente em contraceptivos orais e medicamentos utilizados na TRH feminina, e estimar o aporte deste estrogênio nos corpos hídricos da área urbana do 1° distrito do município de Santa Maria Madalena. Para o desenvolvimento deste trabalho utilizou-se como metodologia um estudo do tipo inquérito realizado com 325 mulheres de 15 a 59 anos de idade, residentes na área de estudo, no período de setembro a dezembro do ano de 2013. Das 325 mulheres entrevistadas, constatou-se que 95 fazem o uso de contraceptivo oral, sendo que destas, 91 fazem uso de formulações que contêm o 17α-etinilestradiol. Tomando a amostra (...) como estatisticamente representativa da área de estudo, pôde-se extrapolar o valor de consumo do 17 α-etinilestradiol para a população total de mulheres (...) na faixa etária estabelecida. Com base nas informações obtidas a partir da elaboração do presente estudo foi possível estimar que há um considerável aporte desta substância nos corpos hídricos da área urbana do 1° distrito do município de Santa Maria Madalena (16 mg/dia), o que sugere a possibilidade de efeitos adversos à biota aquática local. Uma vez que o presente estudo não encerra a discussão sobre o assunto, ao fim desta dissertação há uma proposição para um trabalho futuro no sentido de se avançar neste tema.

The presence of organic contaminants with estrogenic activity in aquatic environment is a topic with growing concern in scientific community, since those contaminants are capable or triggering adverse effects to the endocrine system of many …

Advisors/Committee Members: Larentis, Ariane Leites, Sarcinelli, Paula de Novaes.

Subjects/Keywords: Contraceptivos Orais; Poluição da Água; Ecotoxicologia; Etinilestradiol; Ethinylestradiol; Oral Contraceptives; Water Pollution; Ecotoxicology; Etinilestradiol/efeitos adversos; Anticoncepcionais Orais; Ecotoxicologia; Poluição da Água

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cunha, D. L. d. (2014). Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ. (Masters Thesis). Brazil. Retrieved from https://www.arca.fiocruz.br/handle/icict/23395

Chicago Manual of Style (16^th Edition):

Cunha, Danieli Lima da. “Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ.” 2014. Masters Thesis, Brazil. Accessed April 15, 2021. https://www.arca.fiocruz.br/handle/icict/23395.

MLA Handbook (7^th Edition):

Cunha, Danieli Lima da. “Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ.” 2014. Web. 15 Apr 2021.

Vancouver:

Cunha DLd. Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ. [Internet] [Masters thesis]. Brazil; 2014. [cited 2021 Apr 15]. Available from: https://www.arca.fiocruz.br/handle/icict/23395.

Council of Science Editors:

Cunha DLd. Avaliação do padrão de consumo do 17α etinilestradiol no município de Santa Maria Madalena, RJ. [Masters Thesis]. Brazil; 2014. Available from: https://www.arca.fiocruz.br/handle/icict/23395

27. Santos, Monalisa dos. ELETRODOS MODIFICADOS PELA TÉCNICA LbL PARA DETECÇÃO DE ESTROGÊNIOS.

Degree: 2014, UNIVERSIDADE ESTADUAL DE PONTA GROSSA; Programa de Pós-Graduação em Química Aplicada; UEPG; BR; Química

URL: http://tede2.uepg.br/jspui/handle/prefix/2131

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Coordenação de Aperfeiçoamento… (more)

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Made available in DSpace on 2017-07-24T19:38:14Z (GMT). No. of bitstreams: 1 Monalisa Santos.pdf: 2681672 bytes, checksum: c32e0b48f967016b011a1aa3693a3b59 (MD5) Previous issue date: 2014-04-24

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

This work presents a study for preparation of thin films obtained with a natural and synthetic polyelectrolyte, such as humic acid (HA) and by the hybrid prepared by encapsulation of platinum nanoparticles in the matrix of chloride 3-n- propylpyridinium silsesquioxane (Pt-SiPy+Cl-). Even when dealing with molecules of complex nature, the film deposition occurred regardless of the type of substrate. It was found that there was growth of films by alternate deposition of polyelectrolytes HA and Pt-SiPy+Cl-, governed largely by electrostatic interactions between functional groups COOH, OH-phenolic of HA with pyridinium ring of SiPy+Cl-. The presence of polyelectrolytes in LbL films built on molecular architectures (HA/Pt-SiPy+Cl-)n and (Pt-SiPy+Cl-/HA)n, was obtained by spectroscopic measurements. From the shifts of the bands in the absorption spectra in the UV-Vis region of LbL films in relation to the precursor solutions, it was inferred on the interactions between these molecules. Measurements of absorption spectroscopy FTIR and Raman scattering of the LbL film were observed by displacement or disappearance of absorption bands due to the presence of precursors of Pt-NPs cavities of SiPy+Cl-. It was found that bands were more intense and defined in the spectra of the film (HA/Pt-SiPy+Cl-)30 in relation to the (Pt-SiPy+Cl-/HA)30 film. This observation corroborates the results of UV-Vis showing that from 12 bilayers no linear growth of absorbance as a function of number of bilayers (Pt-SiPy+Cl-/HA)12. The AFM images showed a linear increase when the film (HA/Pt-SiPy+Cl-)30 was obtained with a thickness of 2.6 nm per bilayer, confirming the nanostructured nature provided by the molecular organization of polyelectrolytes. Morphological characterization showed that the homogeneity of the surface in function of the amount of deposited materials influence of surface phenomena, such as the number of active sites, as evidenced by electrochemical action of the hormone 17α - ethinylestradiol (EE2). From the diferential pulse voltammetric response of the investigated in the presence of EE2 6.25 x 10-5 mol L-1, it was found that the film (HA/Pt-SiPy+Cl-)3 showed high peak current (Ipa = 17.26 μA) and minor oxidation potential (Epa = 0,74 V vs Ag/AgCl) in relation to no modified electrode (FTO) (Ipa = 8,97 μA e Epa = 1,1 V). Under these conditions , the electrode (HA/Pt-SiPy+Cl-)3 obtained a linear response in the concentration range of 1.37 x 10-6 to 2.14 x 10-5 mol L- 1, yielding a sensitivity 0.68 mmol L-1 and limits of detection ( LOD) and quantification (LOQ ) equal to 1.06 x 10-6 and 3.52 x 10-6 mol L-1 . These values are close to those reported in the literature for electrodes modified with metals nanoparticles. Finally, the technique of electrochemical impedance…

Advisors/Committee Members: Wohnrath, Karen, Sheffer, Elizabeth Weinhardt de Oliveira, Fujiwara, Sérgio Toshio, Quinaia, Sueli Pércio.

Subjects/Keywords: ácido húmico; nanopartículas de platina; silsesquioxano; 17α; -etinilestradiol; poluentes emergentes; humic acid; platinum nanoparticles; silsesquioxane; 17α; -ethinylestradiol; emerging pollutants; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos, M. d. (2014). ELETRODOS MODIFICADOS PELA TÉCNICA LbL PARA DETECÇÃO DE ESTROGÊNIOS. (Masters Thesis). UNIVERSIDADE ESTADUAL DE PONTA GROSSA; Programa de Pós-Graduação em Química Aplicada; UEPG; BR; Química. Retrieved from http://tede2.uepg.br/jspui/handle/prefix/2131

Chicago Manual of Style (16^th Edition):

Santos, Monalisa dos. “ELETRODOS MODIFICADOS PELA TÉCNICA LbL PARA DETECÇÃO DE ESTROGÊNIOS.” 2014. Masters Thesis, UNIVERSIDADE ESTADUAL DE PONTA GROSSA; Programa de Pós-Graduação em Química Aplicada; UEPG; BR; Química. Accessed April 15, 2021. http://tede2.uepg.br/jspui/handle/prefix/2131.

MLA Handbook (7^th Edition):

Santos, Monalisa dos. “ELETRODOS MODIFICADOS PELA TÉCNICA LbL PARA DETECÇÃO DE ESTROGÊNIOS.” 2014. Web. 15 Apr 2021.

Vancouver:

Santos Md. ELETRODOS MODIFICADOS PELA TÉCNICA LbL PARA DETECÇÃO DE ESTROGÊNIOS. [Internet] [Masters thesis]. UNIVERSIDADE ESTADUAL DE PONTA GROSSA; Programa de Pós-Graduação em Química Aplicada; UEPG; BR; Química; 2014. [cited 2021 Apr 15]. Available from: http://tede2.uepg.br/jspui/handle/prefix/2131.

Council of Science Editors:

Santos Md. ELETRODOS MODIFICADOS PELA TÉCNICA LbL PARA DETECÇÃO DE ESTROGÊNIOS. [Masters Thesis]. UNIVERSIDADE ESTADUAL DE PONTA GROSSA; Programa de Pós-Graduação em Química Aplicada; UEPG; BR; Química; 2014. Available from: http://tede2.uepg.br/jspui/handle/prefix/2131

28. Stegeman, Berendina Hendrika (Bernardine). Hormonal contraceptives and venous thrombosis.

Degree: 2013, Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Library (LUMC), Leiden University

URL: http://hdl.handle.net/1887/20865

► Oral contraceptive use is associated with venous thrombosis. However, the mechanism behind this remains unclear. The aim of this thesis was to evaluate genetic variation… (more)

Subjects/Keywords: Oral contraceptive; Ethinylestradiol; Progestagen; Sex hormone binding globulin (SHBG); Venous thrombosis; Recurrence; Oral contraceptive; Ethinylestradiol; Progestagen; Sex hormone binding globulin (SHBG); Venous thrombosis; Recurrence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stegeman, B. H. (. (2013). Hormonal contraceptives and venous thrombosis. (Doctoral Dissertation). Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Library (LUMC), Leiden University. Retrieved from http://hdl.handle.net/1887/20865

Chicago Manual of Style (16^th Edition):

Stegeman, Berendina Hendrika (Bernardine). “Hormonal contraceptives and venous thrombosis.” 2013. Doctoral Dissertation, Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Library (LUMC), Leiden University. Accessed April 15, 2021. http://hdl.handle.net/1887/20865.

MLA Handbook (7^th Edition):

Stegeman, Berendina Hendrika (Bernardine). “Hormonal contraceptives and venous thrombosis.” 2013. Web. 15 Apr 2021.

Vancouver:

Stegeman BH(. Hormonal contraceptives and venous thrombosis. [Internet] [Doctoral dissertation]. Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Library (LUMC), Leiden University; 2013. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1887/20865.

Council of Science Editors:

Stegeman BH(. Hormonal contraceptives and venous thrombosis. [Doctoral Dissertation]. Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Library (LUMC), Leiden University; 2013. Available from: http://hdl.handle.net/1887/20865

University of Bradford

29. Mezughi, Khaled M. Heterogeneous photocatalytic degradation of organic pollutants in water over nanoscale powdered titanium dioxide : the photocatalytic degradation of organic compounds in water (Reactive Orange 16, Triclocarbon, Clopyralid and Estrogens (estrone, 17ß-estradiol, and 17α-ethinylestradiol)) was studied : the reaction kinetics and the effect of the operating parameters on the performance of the system were determined; a comparison with other advanced oxidation processes (O₃, H₂O₂, UV) was also made.

Degree: PhD, 2010, University of Bradford

URL: http://hdl.handle.net/10454/4865

► Organic contaminants from industrial and/or domestic effluents may be harmful to humans directly or indirectly by degrading the quality of the aquatic environment. Consequently these… (more)

▼ Organic contaminants from industrial and/or domestic effluents may be harmful to humans directly or indirectly by degrading the quality of the aquatic environment. Consequently these contaminants must be reduced to levels that are not harmful to humans and the environment before disposal. Chemical, physical and biological methods exist for the removal of these pollutants from effluents. Among the available chemical methods, heterogeneous photocatalytic oxidation has been found particularly effective in removing a large number of persistent organics in water. In this study, photocatalytic degradation was explored for the removal of reactive azo-dye (textile dye), triclocarban (disinfectant), clopyralid (herbicide) and three endocrine disrupting compounds (EDCs) (estrone, 17ß-estradiol and 17α-ethinylestradiol) from synthetic effluents. The major factors affecting the photocatalytic processes including the initial concentration of the target compounds, the amount of catalyst, the light intensity, the type of catalyst, the electron acceptor, the irradiation time and the pH were studied. Other oxidation techniques including (O3, H2O2, UV) were also studied. Generally UV light is used in combination with titanium dioxide, as photocatalyst, to generate photoinduced charge separation leading to the creation of electron-hole pairs. The holes act as electron acceptors hence the oxidation of organics occur at these sites. These holes can also lead to the formation of hydroxyl radicals which are also effective oxidants capable of degrading the organics. The results obtained in this study indicated that photolysis (i.e. UV only) was found to have no effect on the degradation of reactive azo-dye (RO16). However, complete photocatalytic degradation of 20 mg/L (3.24×10-2 mM) RO16 was achieved in 20 minutes in the presence of 1g/L TiO2 Degussa P25 at pH 5.5. Comparison between various types of catalysts (i.e. Degussa P25, VP Aeroperl, Hombifine N) gave varied results but Degussa P25 was the most effective photocatalyst hence it was selected for this study. For RO16 the optimum catalyst concentration was 0.5 g/L TiO2 with initial concentration of 20 mg/L RO16. It was found that the disappearance of RO16 satisfactorily followed the pseudo first-order kinetics according to Langmuir-Hinshelwood (L-H) model. The rate constant was k= 0.0928 mol/min. Photodegradation of TCC was studied in 70%v acetonitrile: 30%v water solutions. UV light degraded TCC effectively and the reaction rates increased with decreasing initial concentration of TCC. UV/TiO2 gave unsatisfactory degradation of triclocarban (TCC) since only 36% were removed in 60 minutes with initial concentration of TCC 20 mg/L. The degradation of clopyralid and the EDCs was studied using three oxidation systems UV/TiO2, UV/H2O2 and O3. Complete degradation of clopyralid (3,6-DCP) was achieved with UV/TiO2 in about 90 minutes at an optimum catalyst concentration of 1g/L. Zero-order kinetics was found to describe the first stage of the photocatalytic reaction in the concentration range…

Subjects/Keywords: 577.27; Organic contaminants; Pollutants; Titanium dioxide; Photocatalytic degradation; Human health; Triclocarban; Clopyralid; Estrone; 17?-estradiol; 17?-ethinylestradiol; Pollutant removal from effluents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mezughi, K. M. (2010). Heterogeneous photocatalytic degradation of organic pollutants in water over nanoscale powdered titanium dioxide : the photocatalytic degradation of organic compounds in water (Reactive Orange 16, Triclocarbon, Clopyralid and Estrogens (estrone, 17ß-estradiol, and 17α-ethinylestradiol)) was studied : the reaction kinetics and the effect of the operating parameters on the performance of the system were determined; a comparison with other advanced oxidation processes (O₃, H₂O₂, UV) was also made. (Doctoral Dissertation). University of Bradford. Retrieved from http://hdl.handle.net/10454/4865

Chicago Manual of Style (16^th Edition):

Mezughi, Khaled M. “Heterogeneous photocatalytic degradation of organic pollutants in water over nanoscale powdered titanium dioxide : the photocatalytic degradation of organic compounds in water (Reactive Orange 16, Triclocarbon, Clopyralid and Estrogens (estrone, 17ß-estradiol, and 17α-ethinylestradiol)) was studied : the reaction kinetics and the effect of the operating parameters on the performance of the system were determined; a comparison with other advanced oxidation processes (O₃, H₂O₂, UV) was also made.” 2010. Doctoral Dissertation, University of Bradford. Accessed April 15, 2021. http://hdl.handle.net/10454/4865.

MLA Handbook (7^th Edition):

Mezughi, Khaled M. “Heterogeneous photocatalytic degradation of organic pollutants in water over nanoscale powdered titanium dioxide : the photocatalytic degradation of organic compounds in water (Reactive Orange 16, Triclocarbon, Clopyralid and Estrogens (estrone, 17ß-estradiol, and 17α-ethinylestradiol)) was studied : the reaction kinetics and the effect of the operating parameters on the performance of the system were determined; a comparison with other advanced oxidation processes (O₃, H₂O₂, UV) was also made.” 2010. Web. 15 Apr 2021.

Vancouver:

Mezughi KM. Heterogeneous photocatalytic degradation of organic pollutants in water over nanoscale powdered titanium dioxide : the photocatalytic degradation of organic compounds in water (Reactive Orange 16, Triclocarbon, Clopyralid and Estrogens (estrone, 17ß-estradiol, and 17α-ethinylestradiol)) was studied : the reaction kinetics and the effect of the operating parameters on the performance of the system were determined; a comparison with other advanced oxidation processes (O₃, H₂O₂, UV) was also made. [Internet] [Doctoral dissertation]. University of Bradford; 2010. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10454/4865.

Council of Science Editors:

Mezughi KM. Heterogeneous photocatalytic degradation of organic pollutants in water over nanoscale powdered titanium dioxide : the photocatalytic degradation of organic compounds in water (Reactive Orange 16, Triclocarbon, Clopyralid and Estrogens (estrone, 17ß-estradiol, and 17α-ethinylestradiol)) was studied : the reaction kinetics and the effect of the operating parameters on the performance of the system were determined; a comparison with other advanced oxidation processes (O₃, H₂O₂, UV) was also made. [Doctoral Dissertation]. University of Bradford; 2010. Available from: http://hdl.handle.net/10454/4865

30. Gomes, Juliana Pinheiro. Análise da ocorrência do hormônio estrogênico, 17 alfa-etinilestradiol, no lago Paranoá.

Degree: 2018, Brazil

URL: https://www.arca.fiocruz.br/handle/icict/34185

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Made available in DSpace on 2019-07-17T13:42:09Z (GMT). No. of bitstreams: 2 juliana_pinheiro.pdf: 2466930 bytes, checksum: 52869dfa0430f75030ac5f0914809084 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2018

Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.

Diversos estudos vêm apontando sobre a ocorrência de contaminantes emergentes nas matrizes aquáticas. Esses poluentes ainda não foram regulamentados, mas têm potencial de afetar a saúde humana e ambiental. Neste grupo de contaminantes, destaca-se o 17αetinilestradiol (EE2), hormônio sintético presente em pílulas anticoncepcionais, com alto potencial estrogênico e de bioacumulação. Dentre seus efeitos como desregulador endócrino, o mais notório é a feminização de peixes. A ocorrência de poluentes emergentes no Lago Paranoá (Distrito Federal – Brasil) é presumida devido ao lançamento de efluentes provenientes de estações de tratamento nesse corpo hídrico e pelo fato dessas estações não terem sido projetadas para a remoção desses tipos de contaminantes. Nesse contexto, considerando que o Lago Paranoá é um manancial, os objetivos desse trabalho foram: quantificar as concentrações de EE2 nesse reservatório, avaliar o desempenho das estações de tratamento de esgoto e de água quanto à remoção de EE2, e caracterizar o risco de exposição involuntária ambiental. Utilizou-se o método ELISA (ensaio de imunoabsorção enzimática) para a realização das análises. Concentrações de EE2 foram quantificadas em todas as amostras de esgoto bruto (1,31 – 2,08 ng. L -1 ) e de efluente tratado (0,23 – 1,50 ng. L -1 ), e em uma das amostras de água superficial do Lago Paranoá (0,07 ng. L -1 ). Nas amostras de água tratada a concentração ficou abaixo do limite mínimo de quantificação do método. O desempenho máximo de remoção de EE2 pelas ETEs foi de 88%, alcançado pela ETE Riacho Fundo, que opera em sistema RBS que remove fósforo. Por outro lado, as demais ETEs que operam com sistema Bardenpho, seguido de coagulação/floculação/ flotação, a remoção foi em torno de 30%. A concentração de 0,07 ng. L -1 quantificada no Lago Paranoá, ficou abaixo das concentrações médias de efeito observado descritas na literatura para animais aquáticos representantes do segundo e do terceiro nível trófico, mas superior às concentrações previstas sem efeito propostas pela Comissão Europeia (0,035 ng. L -1 ).…

Advisors/Committee Members: Oliveira, Jaime Lopes da Mota, Mello, Mauricio Homem de.

Subjects/Keywords: Poluente emergente; 17α-etinilestradiol; ELISA; Esgoto sanitário; Lago Paranoá; Emerging pollutant; 17α - ethinylestradiol; ELISA; Sanitary sewage; Paranoá Lake; Poluentes Ambientais; Etinilestradiol; Ensaio de Imunoadsorção Enzimática; Esgotos; Poluição de Lagos e Barragens

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gomes, J. P. (2018). Análise da ocorrência do hormônio estrogênico, 17 alfa-etinilestradiol, no lago Paranoá. (Masters Thesis). Brazil. Retrieved from https://www.arca.fiocruz.br/handle/icict/34185

Chicago Manual of Style (16^th Edition):

Gomes, Juliana Pinheiro. “Análise da ocorrência do hormônio estrogênico, 17 alfa-etinilestradiol, no lago Paranoá.” 2018. Masters Thesis, Brazil. Accessed April 15, 2021. https://www.arca.fiocruz.br/handle/icict/34185.

MLA Handbook (7^th Edition):

Gomes, Juliana Pinheiro. “Análise da ocorrência do hormônio estrogênico, 17 alfa-etinilestradiol, no lago Paranoá.” 2018. Web. 15 Apr 2021.

Vancouver:

Gomes JP. Análise da ocorrência do hormônio estrogênico, 17 alfa-etinilestradiol, no lago Paranoá. [Internet] [Masters thesis]. Brazil; 2018. [cited 2021 Apr 15]. Available from: https://www.arca.fiocruz.br/handle/icict/34185.

Council of Science Editors:

Gomes JP. Análise da ocorrência do hormônio estrogênico, 17 alfa-etinilestradiol, no lago Paranoá. [Masters Thesis]. Brazil; 2018. Available from: https://www.arca.fiocruz.br/handle/icict/34185

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