subject:( Energy metabolism)

University of Utah

1. Hao, Huaixiang. Cellular Energy Homeostasis: A Nutrient sensing Kinase and a Mitochondrial Tumor.

Degree: PhD, Biochemistry;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2089/rec/189

► Obesity, type 2 diabetes and cancer are serious threats to human health and are increasing at an alarming rate. Dysregulation of energy homeostasis, both at… (more)

▼ Obesity, type 2 diabetes and cancer are serious threats to human health and are increasing at an alarming rate. Dysregulation of energy homeostasis, both at the whole body and cellular level, has been implicated in the pathogenesis of those disorders. Cellular energy homeostasis is a delicate balance between ATP production and consumption. ATP production, mainly from oxidative phosphorylation in mitochondria, is responsive to nutrient availability and cellular energy demand. Therefore, nutrient sensing is critical to maintain cellular energy homeostasis. There are two wellcharacterized nutrient sensing kinases, AMPK and mTOR. We studied another nutrientresponsive kinase named PASK. Using PASKA mice, the role of PASK in cellular energy homeostasis was revealed. PASK deletion caused nearly complete protection from the deleterious effects of a high-fat diet, including obesity, insulin resistance and hepatic steatosis. This protection is likely due to the increased metabolic rate of PASKA mice, which can be recapitulated in cultured cells upon PASK knockdown. Therefore, we conclude that PASK acts as a cell-autonomous metabolic sensor to maintain cellular energy homeostasis. In addition to PASK, we studied a previously uncharacterized but highly conserved mitochondrial protein that we later named Sdh5. Using yeast as primary model system, we showed that Sdh5 is necessary and probably sufficient for insertion of the requisite FAD cofactor into the catalytic subunit of the succinate dehydrogenase (SDH) complex. SDH deficiency has been associated with several types of cancer, predominantly paraganglioma (PGL). Indeed, three out of four familial PGL genes have been mapped to SDH subunits. We discovered a point mutation in the human SDH5 gene that perfectly cosegregates with disease in a Dutch PGL2 lineage. This mutation completely abolishes hSDH5 function and, as expected, PGL2 tumors exhibit a loss of FAD insertion in succinate dehydrogenase. Our studies of PASK and SDH5 not only contribute significant conceptual advances in cellular nutrient sensing and mitochondrial metabolism, but also provides new screening biomarkers and therapeutic targets for diagnosing and treating the metabolic syndrome and cancer.

Subjects/Keywords: Homeostasis; Energy Metabolism

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APA (6^th Edition):

Hao, H. (2010). Cellular Energy Homeostasis: A Nutrient sensing Kinase and a Mitochondrial Tumor. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2089/rec/189

Chicago Manual of Style (16^th Edition):

Hao, Huaixiang. “Cellular Energy Homeostasis: A Nutrient sensing Kinase and a Mitochondrial Tumor.” 2010. Doctoral Dissertation, University of Utah. Accessed March 06, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2089/rec/189.

MLA Handbook (7^th Edition):

Hao, Huaixiang. “Cellular Energy Homeostasis: A Nutrient sensing Kinase and a Mitochondrial Tumor.” 2010. Web. 06 Mar 2021.

Vancouver:

Hao H. Cellular Energy Homeostasis: A Nutrient sensing Kinase and a Mitochondrial Tumor. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Mar 06]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2089/rec/189.

Council of Science Editors:

Hao H. Cellular Energy Homeostasis: A Nutrient sensing Kinase and a Mitochondrial Tumor. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2089/rec/189

2. Latha, R. Bio-chemical and molecular characterization of DDT degrading dehalogenase from pseudomonas spp.; -.

Degree: Biotechnology, 2006, University of Mysore

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13612

►

1, 1, 1- trichloro- 2,2- bis (p- chlorophenyl) ethane (DDT) is one of the most widely used organochlorine pesticides around the globe. It is one… (more)

▼

1, 1, 1- trichloro- 2,2- bis (p- chlorophenyl) ethane (DDT) is one of the most widely used organochlorine pesticides around the globe. It is one of the most toxic and environmentally persistent organic pollutant. Ten bacterial cultures belonging to DDT degrading microbial consortium were screened for the DDT- dehydrohalogenase activity. Among these, the cell free extract of Pseudomonas putida T5 showed higher DDT-dehydrohalogenase activity and enzyme was purified to apparent homogeneity with 73% overall recovery. The relative molecular mass of the enzyme estimated by the SDS PAGE method was ~32kDa. Native PAGE revealed the presence of a single band. The purity of the enzyme was confirmed by HPLC and capillary electrophoresis. The enzyme was stable for 4-5 h at pH 7.0 at the temperature optima of 37 °C. The Km and Vmax, values for DDT- dehydrohalogenase were 3.7 µM and 6.8 and#956;M min-1, respectively. The enzyme was a glycoprotein with mannose forming the backbone. AIG- formed the N-terminus chain. Serine and tryptophan appeared to be involved at the active site. The enzyme appeared to be a metalloprotein containing Zn, Mg, and Ca ions. Monovalent and divalent cations (1mM) inhibited the enzyme strongly. The primary sequence of HPLC purified enzyme was deduced by LC-MS-MALDI-ESI. newlineUrea, sodium dodecyl sulfate (SDS) and guanidine hydrochloride (GdmCl) are often used as excellent denaturing or unfolding agents. The effect of these denaturing agents on the structural changes of DDT- enzyme of Psuedomonas putida T5 were studied. There was a progressive loss in catalytic activity of DDT- dehydrochlorinase with increasing concentrations of denaturants, namely urea, SDS and GdmCl. At 10 M urea, 5 % SDS and 1 M GdmCl, the extent of loss in enzyme activity was 98, 78 and 100% respectively. The emission spectrum of urea denatured enzyme did not show shift, but that of SDS and GdmCl treated enzyme showed very marginal shift.

Summary p.313-317

Advisors/Committee Members: Manonmani, H K.

Subjects/Keywords: Biotechnology; microorganisms; Energy Metabolism; dehydrohalogenase

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APA (6^th Edition):

Latha, R. (2006). Bio-chemical and molecular characterization of DDT degrading dehalogenase from pseudomonas spp.; -. (Thesis). University of Mysore. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13612

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Latha, R. “Bio-chemical and molecular characterization of DDT degrading dehalogenase from pseudomonas spp.; -.” 2006. Thesis, University of Mysore. Accessed March 06, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/13612.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Latha, R. “Bio-chemical and molecular characterization of DDT degrading dehalogenase from pseudomonas spp.; -.” 2006. Web. 06 Mar 2021.

Vancouver:

Latha R. Bio-chemical and molecular characterization of DDT degrading dehalogenase from pseudomonas spp.; -. [Internet] [Thesis]. University of Mysore; 2006. [cited 2021 Mar 06]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13612.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Latha R. Bio-chemical and molecular characterization of DDT degrading dehalogenase from pseudomonas spp.; -. [Thesis]. University of Mysore; 2006. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13612

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Wisconsin – La Cross

3. Buermann, Megan E. Turn it on: relative intensity and caloric expenditure of qidance.

Degree: 2012, University of Wisconsin – La Cross

URL: http://digital.library.wisc.edu/1793/62257

► Popular trends in aerobic group classes have emerged over the years. The recent increase in group classes attracts individuals who are exploring other types of… (more)

Subjects/Keywords: Exercise; Physical fitness; Energy metabolism

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APA (6^th Edition):

Buermann, M. E. (2012). Turn it on: relative intensity and caloric expenditure of qidance. (Thesis). University of Wisconsin – La Cross. Retrieved from http://digital.library.wisc.edu/1793/62257

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Buermann, Megan E. “Turn it on: relative intensity and caloric expenditure of qidance.” 2012. Thesis, University of Wisconsin – La Cross. Accessed March 06, 2021. http://digital.library.wisc.edu/1793/62257.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Buermann, Megan E. “Turn it on: relative intensity and caloric expenditure of qidance.” 2012. Web. 06 Mar 2021.

Vancouver:

Buermann ME. Turn it on: relative intensity and caloric expenditure of qidance. [Internet] [Thesis]. University of Wisconsin – La Cross; 2012. [cited 2021 Mar 06]. Available from: http://digital.library.wisc.edu/1793/62257.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Buermann ME. Turn it on: relative intensity and caloric expenditure of qidance. [Thesis]. University of Wisconsin – La Cross; 2012. Available from: http://digital.library.wisc.edu/1793/62257

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

4. Karlsson, Håkan, 1950-. Regional skin temperature and dry heat flow : a study of energy loss in newborn babies.

Degree: 1996, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/12183

Subjects/Keywords: Energy metabolism

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APA (6^th Edition):

Karlsson, Håkan, 1. (1996). Regional skin temperature and dry heat flow : a study of energy loss in newborn babies. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/12183

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Karlsson, Håkan, 1950-. “Regional skin temperature and dry heat flow : a study of energy loss in newborn babies.” 1996. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 06, 2021. http://hdl.handle.net/2077/12183.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Karlsson, Håkan, 1950-. “Regional skin temperature and dry heat flow : a study of energy loss in newborn babies.” 1996. Web. 06 Mar 2021.

Vancouver:

Karlsson, Håkan 1. Regional skin temperature and dry heat flow : a study of energy loss in newborn babies. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1996. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2077/12183.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karlsson, Håkan 1. Regional skin temperature and dry heat flow : a study of energy loss in newborn babies. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1996. Available from: http://hdl.handle.net/2077/12183

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

5. Attwood, William Shofner, 1948-. A comparison of two methods for determining energy cost during sports performance .

Degree: 1973, University of Arizona

URL: http://hdl.handle.net/10150/347824

Subjects/Keywords: Energy metabolism.

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APA (6^th Edition):

Attwood, William Shofner, 1. (1973). A comparison of two methods for determining energy cost during sports performance . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/347824

Chicago Manual of Style (16^th Edition):

Attwood, William Shofner, 1948-. “A comparison of two methods for determining energy cost during sports performance .” 1973. Masters Thesis, University of Arizona. Accessed March 06, 2021. http://hdl.handle.net/10150/347824.

MLA Handbook (7^th Edition):

Attwood, William Shofner, 1948-. “A comparison of two methods for determining energy cost during sports performance .” 1973. Web. 06 Mar 2021.

Vancouver:

Attwood, William Shofner 1. A comparison of two methods for determining energy cost during sports performance . [Internet] [Masters thesis]. University of Arizona; 1973. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10150/347824.

Council of Science Editors:

Attwood, William Shofner 1. A comparison of two methods for determining energy cost during sports performance . [Masters Thesis]. University of Arizona; 1973. Available from: http://hdl.handle.net/10150/347824

University of New South Wales

6. Lau, Ka Yan Jackie. CART in the regulation of appetite and energy homeostasis.

Degree: Garvan Institute of Medical Research, 2016, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/56766 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41393/SOURCE02?view=true

► CART is a key neuropeptide with predominant expression in the hypothalamus central to appetite control and energy homeostasis. However, the underlying mechanisms and sites of… (more)

▼ CART is a key neuropeptide with predominant expression in the hypothalamus central to appetite control and energy homeostasis. However, the underlying mechanisms and sites of action of CART remain unclear, leading to discrepant implications for CART function. This is mainly due to the lack of specific pharmacological tools as the CART receptor(s) are yet to be identified. Utilizing a novel CART-cre knock-in mouse line, this work aims to determine the impact of CART action on energy balance, by means of transgenic mouse models, CART introduction or neuronal activation, and changes in ambient temperature. To study the potential contribution of CART to thermoregulation and diet-induced obesity, CART-deficient CARTcre/cre mice were subjected to thermoneutrality (30 ˚C) and high fat diet (HFD). Whilst CART KO mice displayed higher adiposity and lower lean mass across temperatures, especially under HFD, the elevated weight gain and thermogenesis under standard housing (22 ˚C) was reversed at thermoneutrality. These effects were accompanied by distinctive neurochemical profiles in CART KO mice. In addition to temperature- and diet-dependence, CART function further exhibited brain region-specificity, as evident in the differential effects of chronic CART introduction via the FLEX switch design into the Arc or LHA, two hypothalamic areas critical for energy balance. Intriguingly, while intra-LHA CART induced obesogenic traits in CARTcre/cre mice, the opposite was observed for the CART-positive CARTcre/+ mice. In contrast, intra-Arc CART displayed anorexigenic effects, particularly in CARTcre/+ mice. The distinctions across genotypes also highlighted in the disparate responses upon CART neuron activation in the Arc or LHA enabled by the DREADD technology. Substantially, both energy expenditure and physical activity were decreased and increased upon CART neuron stimulation in the Arc and LHA, respectively, particularly in CARTcre/+ mice. The discrete phenotypes may attribute to the interaction of endogenous CART with other neuromodulators such as NPY. Accordingly, selective deletion of NPY-Y1 receptor on CART neurons achieved in our unique CARTcre/+;Y1lox/lox mouse line suppressed adipose accretion and weight gain, endorsing the direct inhibition of CART action by Y1R signaling. In sum, this study demonstrates that CART activity exhibits pivotal, divergent and site-specific effects on food intake and energy balance. Advisors/Committee Members: Herzog, Herbert, Garvan Institute of Medical Research, Faculty of Medicine, UNSW, Shi, Yanchuan, Garvan Institute of Medical Research, Faculty of Medicine, UNSW.

Subjects/Keywords: Metabolism; CART; Energy homeostasis; Hypothalamus

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APA (6^th Edition):

Lau, K. Y. J. (2016). CART in the regulation of appetite and energy homeostasis. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/56766 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41393/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Lau, Ka Yan Jackie. “CART in the regulation of appetite and energy homeostasis.” 2016. Doctoral Dissertation, University of New South Wales. Accessed March 06, 2021. http://handle.unsw.edu.au/1959.4/56766 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41393/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Lau, Ka Yan Jackie. “CART in the regulation of appetite and energy homeostasis.” 2016. Web. 06 Mar 2021.

Vancouver:

Lau KYJ. CART in the regulation of appetite and energy homeostasis. [Internet] [Doctoral dissertation]. University of New South Wales; 2016. [cited 2021 Mar 06]. Available from: http://handle.unsw.edu.au/1959.4/56766 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41393/SOURCE02?view=true.

Council of Science Editors:

Lau KYJ. CART in the regulation of appetite and energy homeostasis. [Doctoral Dissertation]. University of New South Wales; 2016. Available from: http://handle.unsw.edu.au/1959.4/56766 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:41393/SOURCE02?view=true

University of Utah

7. Chen, Meng. In vivo nuclear magnetic resonance studies on cerebral energy metabolism and age related isoflurane elimination from rat brain;.

Degree: PhD, Biochemistry;, 1994, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1308/rec/669

► In vivo nuclear magnetic resonance (NMR) was employed to study cerebral energy metabolism under hypoxia, cerebral blood flow (CBF), and isoflurane elimination kinetics as a… (more)

▼ In vivo nuclear magnetic resonance (NMR) was employed to study cerebral energy metabolism under hypoxia, cerebral blood flow (CBF), and isoflurane elimination kinetics as a function of age in rat brain. Three nuclei were involved: 31P for energy metabolism, 2H for monitoring D2O clearance to calculate cerebral blood flow and 19F for studying isoflurane kinetics and T1 and T2 relaxation times. Energy metabolites were monitored by 31P NMR in both horizontal and vertical magnets on rat brain experiencing the same level of hypoxia. The changes in PCr, Pi and pHi in the vertical position toward the end of hypoxia were significantly larger and the recovery in the horizontal animals was more complete. These results demonstrated quantitatively that the stress of the vertical alignment on the supine animal is superimposed upon the stress of hypoxia in the vertical experiment. Cerebral blood flow measurement by 2H NMR using the deuterium oxide internal carotid artery injection method was established. Values of global CBF were in the same range as those reported using other methods and were found to be linearly correlated with arterial CO2 tension (PaCO2). Measurements in a single animal can be repeated several times to obtain reproducible values under the same physiological condition or different values under altered physiological conditions. Isoflurane elimination from rat brain as a function of age was studied by 19F NMR. The results showed that the elimination from both young and old rat brain was biphasic whereas the half lives (t1/2) of both the fast and slow components for the old were 15% slower than their counterparts of the young rat group. Similar age attenuation was also found from arterial blood elimination to the same extent with a monophasic process as measured by gas chromatography. Longitudinal relaxation (T1) measurements showed monoexponential recovery and no age difference. T1 recovery in dipalmitoylphosphatidylcholine (DPPC) vesicles was longer indicating less restricted motion compared with that in the intact brain. Transverse relaxation recovery in DPPC vesicles was also monoexponential. This dissertation has demonstrated that in vivo NMR is a useful noninvasive tool in the studying of energy metabolism and pharmacokinetics of fluorinated drugs in rodent brain.

Subjects/Keywords: Dipalmitoylphosphatidylcholine; Energy Metabolism

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APA (6^th Edition):

Chen, M. (1994). In vivo nuclear magnetic resonance studies on cerebral energy metabolism and age related isoflurane elimination from rat brain;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1308/rec/669

Chicago Manual of Style (16^th Edition):

Chen, Meng. “In vivo nuclear magnetic resonance studies on cerebral energy metabolism and age related isoflurane elimination from rat brain;.” 1994. Doctoral Dissertation, University of Utah. Accessed March 06, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1308/rec/669.

MLA Handbook (7^th Edition):

Chen, Meng. “In vivo nuclear magnetic resonance studies on cerebral energy metabolism and age related isoflurane elimination from rat brain;.” 1994. Web. 06 Mar 2021.

Vancouver:

Chen M. In vivo nuclear magnetic resonance studies on cerebral energy metabolism and age related isoflurane elimination from rat brain;. [Internet] [Doctoral dissertation]. University of Utah; 1994. [cited 2021 Mar 06]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1308/rec/669.

Council of Science Editors:

Chen M. In vivo nuclear magnetic resonance studies on cerebral energy metabolism and age related isoflurane elimination from rat brain;. [Doctoral Dissertation]. University of Utah; 1994. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1308/rec/669

Cornell University

8. McCarthy, Maris. Hepatic Energy Metabolism In Early Lactation Dairy Cows.

Degree: PhD, Animal Science, 2015, Cornell University

URL: http://hdl.handle.net/1813/41136

► In the period immediately following calving, feed intake is insufficient to support the high milk production of early lactation, resulting in a state of negative… (more)

▼ In the period immediately following calving, feed intake is insufficient to support the high milk production of early lactation, resulting in a state of negative energy balance. This state of negative energy balance results in many metabolic adaptations such as the increased mobilization of adipose tissue, manifested as the release of non-esterified fatty acids into circulation to be metabolized by the liver and other tissues and incorporated into milk fat in the mammary gland. Propionate that is produced via fermentation of starch in the rumen is the main precursor for hepatic glucose production, and higher feed and energy intake postpartum generally results in lower circulating non-esterified fatty acids and has been associated with improved health, performance, and less severe postpartum negative energy balance. The objectives herein were to: 1) evaluate the effects of different energetic nutritional strategies on postpartum production and metabolism; 2) evaluate the impact of these nutritional strategies on liver metabolism; 3) evaluate temporal changes in liver metabolism through the transition to lactation and the relationships between hepatic energy substrates; and 4) evaluate the association between the degree of early lactation inflammation with production and metabolism. Cows that were fed diets with greater propiogenic capacity during the postpartum period had improvements in production and metabolism, and increased in vitro conversion of propionate to glucose in the liver. Overall, alterations in fatty acid metabolism that lead to increased triglyceride accumulation during the transition period appear to impair postpartum hepatic gluconeogenesis, and cows that had elevated inflammation in the first week postpartum exhibited a diverse range of production responses, indicating that there is a large degree of variation in individual adaptation. Advisors/Committee Members: Overton,Thomas R (chair), Brenna,James Thomas (committee member), Van Amburgh,Michael E (committee member), Nydam,Daryl Van (committee member).

Subjects/Keywords: Transition dairy cow; Hepatic energy metabolism; Nutrition

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APA (6^th Edition):

McCarthy, M. (2015). Hepatic Energy Metabolism In Early Lactation Dairy Cows. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/41136

Chicago Manual of Style (16^th Edition):

McCarthy, Maris. “Hepatic Energy Metabolism In Early Lactation Dairy Cows.” 2015. Doctoral Dissertation, Cornell University. Accessed March 06, 2021. http://hdl.handle.net/1813/41136.

MLA Handbook (7^th Edition):

McCarthy, Maris. “Hepatic Energy Metabolism In Early Lactation Dairy Cows.” 2015. Web. 06 Mar 2021.

Vancouver:

McCarthy M. Hepatic Energy Metabolism In Early Lactation Dairy Cows. [Internet] [Doctoral dissertation]. Cornell University; 2015. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1813/41136.

Council of Science Editors:

McCarthy M. Hepatic Energy Metabolism In Early Lactation Dairy Cows. [Doctoral Dissertation]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/41136

Texas A&M University

9. Jordan, Emily 1985-. Melanocortin-5 Receptor Role in Energy Balance.

Degree: MS, Nutrition, 2011, Texas A&M University

URL: http://hdl.handle.net/1969.1/186980

► Metabolic disorders, including obesity and fatty acid oxidation disorders (FODs), occur in approximately 34% of the American population and in 1 in every 10,000 Americans,… (more)

▼ Metabolic disorders, including obesity and fatty acid oxidation disorders (FODs), occur in approximately 34% of the American population and in 1 in every 10,000 Americans, respectively (19, 55). Melanocortin-5 receptor (MC5R) is one of five G-protein coupled receptors that are known to mediate effects of melanocortins. Emerging evidence has linked MC5R to multiple metabolic disorders. Previous studies have provided evidence that MC5R helps to regulate lipid metabolism in the skeletal muscle, liver, and white adipose tissue, and in the skin and exocrine glands of vertebrates. We, therefore, tested the hypothesis that MC5R promotes FAO in skeletal muscle. In the present study, MC5R knock-out (KO) mice and wild-type (WT) mice were placed on a low-fat or high-fat diet for 9 weeks. Methods including body weight gain and food intake determinations, behavioral testing to be assessed in future studies, insulin tolerance testing (ITT), and reverse transcription PCR (RT-PCR) were used to provide a picture of overall energy balance and metabolic activity in tissues. Results suggest that obesity induced MC5R (KO) mice, relative to WT mice, display a decrease in FAO not only in the skeletal muscle, but in the liver as well. We also show that to compensate for the loss of FAO in skeletal muscle, MC5R KO mice experience an increase in FAO in brown adipose tissue (BAT) and an increase in adipogenesis in the liver. Not only does lipid metabolism activity shift to liver, data suggests that the glycolytic activity in skeletal muscle decreases and is again reallocated to the liver. Furthermore, we demonstrate that insulin sensitivity is maintained in MC5R KO mice on high-fat diet, in contrast to the decrease in sensitivity in WT mice on high-fat diet. These data collectively suggest that MC5R is extensively involved in overall lipid and glucose metabolism and not only shifts lipolysis and lipogenesis in the body, but may be involved in the dissociation of obesity and insulin resistance. Advisors/Committee Members: Morgan, Caurnel (advisor), Wellman, Paul (committee member), Wu, Chaodong (committee member).

Subjects/Keywords: energy balance; metabolism; Melanocortin-5 receptor

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APA (6^th Edition):

Jordan, E. 1. (2011). Melanocortin-5 Receptor Role in Energy Balance. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/186980

Chicago Manual of Style (16^th Edition):

Jordan, Emily 1985-. “Melanocortin-5 Receptor Role in Energy Balance.” 2011. Masters Thesis, Texas A&M University. Accessed March 06, 2021. http://hdl.handle.net/1969.1/186980.

MLA Handbook (7^th Edition):

Jordan, Emily 1985-. “Melanocortin-5 Receptor Role in Energy Balance.” 2011. Web. 06 Mar 2021.

Vancouver:

Jordan E1. Melanocortin-5 Receptor Role in Energy Balance. [Internet] [Masters thesis]. Texas A&M University; 2011. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1969.1/186980.

Council of Science Editors:

Jordan E1. Melanocortin-5 Receptor Role in Energy Balance. [Masters Thesis]. Texas A&M University; 2011. Available from: http://hdl.handle.net/1969.1/186980

Colorado State University

10. Paris, Hunter LouisRoss. What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux.

Degree: MS(M.S.), Health and Exercise Science, 2014, Colorado State University

URL: http://hdl.handle.net/10217/84047

► INTRODUCTION: Weight regain after weight loss is the experience of most obese dieters. Metabolic adjustments characterized by decreased resting metabolic rate (RMR) and increased hunger… (more)

Subjects/Keywords: energy balance; weight loss; obesity; metabolism

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APA (6^th Edition):

Paris, H. L. (2014). What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/84047

Chicago Manual of Style (16^th Edition):

Paris, Hunter LouisRoss. “What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux.” 2014. Masters Thesis, Colorado State University. Accessed March 06, 2021. http://hdl.handle.net/10217/84047.

MLA Handbook (7^th Edition):

Paris, Hunter LouisRoss. “What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux.” 2014. Web. 06 Mar 2021.

Vancouver:

Paris HL. What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux. [Internet] [Masters thesis]. Colorado State University; 2014. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10217/84047.

Council of Science Editors:

Paris HL. What goes down need not go back up: decreasing the biological drive toward weight regain by increasing energy flux. [Masters Thesis]. Colorado State University; 2014. Available from: http://hdl.handle.net/10217/84047

University of Miami

11. Fernando, Hanan Nirosha. Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells.

Degree: MS, Biomedical Engineering (Engineering), 2010, University of Miami

URL: https://scholarlyrepository.miami.edu/oa_theses/286

► Back pain is the second most common neurological ailment in the United States and the leading cause of pain and disability. More than 80%… (more)

▼ Back pain is the second most common neurological ailment in the United States and the leading cause of pain and disability. More than 80% of the total US population experiences back-pain during their life time and the annual back pain related healthcare costs exceed 100 billion dollars. While the exact cause of low back pain (LBP) is still unknown, degeneration of the intervertebral disc (IVD) has been suggested as a primary contributor. IVD is the largest avascular tissue in the human body and it is composed of three integrated tissues (annulus fibrosus - AF, nucleus pulposus - NP and cartilaginous end plate - CEP). IVD functions as a shock-absorber during motion and provides flexibility to motion of the spine. Maintaining IVD tissue integrity is an energy demanding process. Studies have shown that mechanical loading affects cellular biosynthesis of IVD tissue and may also promote IVD degeneration. However the path to this effect is still unknown. We propose a link between mechanical loading and cell energy production which contributes to altered cellular biosynthesis. Thus, we investigated the effects of mechanical loading on IVD cell energy metabolism under various mechanical loading regimes. Porcine AF and NP cells were isolated and seeded in 2% agarose at a 5,000,000 cells/mL cell density. A custom made bioreactor was used to conduct compression experiments. The experiment groups were: 15% static compression; 30% static compression; 0.1, 1 and 2 Hz dynamic compression at 15% strain magnitude. Experiment duration was 4 hr. ATP concentration in cell-agarose construct and culture media were measured using Luciferin-luciferase method to evaluate ATP production and ATP release from cells respectively. Lactate concentration in media was measured using lactate dehydrogenase enzymatic assay. Nitrite (stable metabolite of nitric oxide - NO) concentration in media was measured by Greiss Assay. DNA content per sample was measured using fluorometric assay. DNA content per sample was used as an internal control; all compressed samples were then normalized to unstrained control group. ATP production of AF cells was up regulated by static and dynamic mechanical loading. Data suggests that AF cell response to mechanical loading is primarily loading amplitude dependent. NP cells exhibited an increased ATP production at 1 Hz dynamic loading but remained comparable to control samples at other tested conditions. AF cells produced an increase in NO production at 1-, 2 Hz dynamic loading. NO production of NP cells was up regulated by mechanical loading at all tested conditions. ATP release was up regulated at higher frequencies in AF cells. In addition to higher frequencies (1 Hz and 2 Hz) NP cell ATP release was also up regulated by 30% static compression. Thus, this study clearly illustrates that mechanical loading affects IVD cell energy production. Advisors/Committee Members: Chun-Yuh (Charles) Huang, Salahadin Abdi, Weiyong Gu.

Subjects/Keywords: ATP; Energy Metabolism; Mechanical Loading; Intervetebral Disc

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fernando, H. N. (2010). Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells. (Thesis). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_theses/286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fernando, Hanan Nirosha. “Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells.” 2010. Thesis, University of Miami. Accessed March 06, 2021. https://scholarlyrepository.miami.edu/oa_theses/286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fernando, Hanan Nirosha. “Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells.” 2010. Web. 06 Mar 2021.

Vancouver:

Fernando HN. Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells. [Internet] [Thesis]. University of Miami; 2010. [cited 2021 Mar 06]. Available from: https://scholarlyrepository.miami.edu/oa_theses/286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fernando HN. Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells. [Thesis]. University of Miami; 2010. Available from: https://scholarlyrepository.miami.edu/oa_theses/286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

12. Narayan, Daniel Sanju. Manipulation of photoreceptor energy metabolism for clinical advantage.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/122058

► Photoreceptors are metabolically active cells that account for the majority of the energy consumption in the retina. Photoreceptors also display high rates of aerobic glycolysis… (more)

▼ Photoreceptors are metabolically active cells that account for the majority of the energy consumption in the retina. Photoreceptors also display high rates of aerobic glycolysis which is unusual in non-proliferating cells. Many diseases of the retina involve degeneration of photoreceptors. Retinitis pigmentosa is the most commonly encountered hereditary retinal dystrophy, featuring degeneration of rod photoreceptors followed by cone photoreceptors. The genetic mutations in retinitis pigmentosa are exclusively expressed in rods, and the secondary death of cones likely involves a component of energy failure. The overriding premise of this thesis was to further our understanding of photoreceptor energy metabolism, then manipulate photoreceptor energy metabolism for clinical advantage using an in vivo model of retinitis pigmentosa. The current thesis comprises three main experiments. In the first experiment, we investigated the role of glucose in the mouse retina and sought to provide an explanation for the high rate of aerobic glycolysis. This was performed by observing the distribution of carbon-14 glucose in the mouse retina using autoradiographic methods. In the second experiment, we characterized the temporal and spatial distribution of cone degeneration in a mouse model of retinitis pigmentosa. Cone quantification was performed using immunohistochemistry and reverse transcription polymerase chain reaction. In the third experiment, we tested two novel bio-energetic agents on the previously characterized mouse model of retinitis pigmentosa. Mice received either systemic creatine, delivered orally, or local glucose, delivered via repeated subconjunctival injection, and the effect on cone survival was measured using immunohistochemistry and neuro-behavioral responses. The results revealed that local glucose injections had no protective effect on cone survival. However, oral creatine treatment preserved cones and improved neuro-behavioral responses in retinal degeneration mice. Therefore, we demonstrated that cone degeneration in retinitis pigmentosa likely occurs due to a mechanism that involves, at least in part, energy failure. Bio-energetic treatments, such as creatine, may play a role as future therapies for retinitis pigmentosa. Further studies will be performed to elucidate the precise mechanisms through which creatine exerts its protective effects, prior to developing a pathway to clinical translation in human patients. Advisors/Committee Members: Casson, Robert (advisor), Chidlow, Glyn (advisor), Wood, John (advisor), Adelaide Medical School (school).

Subjects/Keywords: Ophthalmology; retina; photoreceptor; energy metabolism; glucose; creatine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Narayan, D. S. (2018). Manipulation of photoreceptor energy metabolism for clinical advantage. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/122058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Narayan, Daniel Sanju. “Manipulation of photoreceptor energy metabolism for clinical advantage.” 2018. Thesis, University of Adelaide. Accessed March 06, 2021. http://hdl.handle.net/2440/122058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Narayan, Daniel Sanju. “Manipulation of photoreceptor energy metabolism for clinical advantage.” 2018. Web. 06 Mar 2021.

Vancouver:

Narayan DS. Manipulation of photoreceptor energy metabolism for clinical advantage. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2440/122058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Narayan DS. Manipulation of photoreceptor energy metabolism for clinical advantage. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/122058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Florida

13. Casella, Leila G. Investigating the Proteinaceous Regulome of the Acinetobacter baumannii.

Degree: 2019, University of South Florida

URL: https://scholarcommons.usf.edu/etd/8345

► Acinetobacter baumannii is an opportunistic pathogen that overtime has evolved into one of the most problematic pathogens due to its ability to overcome antibiotic pressures… (more)

Subjects/Keywords: Energy; Gene Regulation; Iron; Metabolism; Microbiology

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APA (6^th Edition):

Casella, L. G. (2019). Investigating the Proteinaceous Regulome of the Acinetobacter baumannii. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/8345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Casella, Leila G. “Investigating the Proteinaceous Regulome of the Acinetobacter baumannii.” 2019. Thesis, University of South Florida. Accessed March 06, 2021. https://scholarcommons.usf.edu/etd/8345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Casella, Leila G. “Investigating the Proteinaceous Regulome of the Acinetobacter baumannii.” 2019. Web. 06 Mar 2021.

Vancouver:

Casella LG. Investigating the Proteinaceous Regulome of the Acinetobacter baumannii. [Internet] [Thesis]. University of South Florida; 2019. [cited 2021 Mar 06]. Available from: https://scholarcommons.usf.edu/etd/8345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Casella LG. Investigating the Proteinaceous Regulome of the Acinetobacter baumannii. [Thesis]. University of South Florida; 2019. Available from: https://scholarcommons.usf.edu/etd/8345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Deakin University

14. Williams, Gareth. Dynamic estimation of human energy expenditure with wearable sensors.

Degree: School of Engineering, 2017, Deakin University

URL: http://hdl.handle.net/10536/DRO/DU:30103527

► This study investigated energy expenditure estimation using inertial measurement units, electromyography and O2 Gas Mask sensors whilst undergoing motion. Further investigations included the precision measurement… (more)

Subjects/Keywords: human movement; exercise; energy metabolism; Electromyography

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APA (6^th Edition):

Williams, G. (2017). Dynamic estimation of human energy expenditure with wearable sensors. (Thesis). Deakin University. Retrieved from http://hdl.handle.net/10536/DRO/DU:30103527

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Williams, Gareth. “Dynamic estimation of human energy expenditure with wearable sensors.” 2017. Thesis, Deakin University. Accessed March 06, 2021. http://hdl.handle.net/10536/DRO/DU:30103527.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Williams, Gareth. “Dynamic estimation of human energy expenditure with wearable sensors.” 2017. Web. 06 Mar 2021.

Vancouver:

Williams G. Dynamic estimation of human energy expenditure with wearable sensors. [Internet] [Thesis]. Deakin University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10536/DRO/DU:30103527.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Williams G. Dynamic estimation of human energy expenditure with wearable sensors. [Thesis]. Deakin University; 2017. Available from: http://hdl.handle.net/10536/DRO/DU:30103527

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Bennett, Rachel. Brain energy metabolism: development and application of novel live methodologies.

Degree: 2012, RIAN

URL: http://eprints.maynoothuniversity.ie/6698/

► This thesis investigates methods of studying brain energy metabolism with a specific focus on the substrates oxygen and glucose. It details the in vitro development… (more)

▼ This thesis investigates methods of studying brain energy metabolism with a specific focus on the substrates oxygen and glucose. It details the in vitro development and in vivo characterisation of microelectrochemical sensors for the detection of brain tissue oxygen, and the in vivo characterisation of oxygen and glucose electrodes in the hippocampus utilising the technique of long-term in vivo electrochemistry (LIVE). Chapter 1 introduces the brain, energy metabolism and neurochemical analysis focusing on oxygen and glucose monitoring in the brain. Chapter 2 discusses the theory relevant to the studies performed in this work, whilst Chapter 3 is a detailed description of sensor construction and techniques used for the in vivo and in vitro characterisation of the sensors utilised in this thesis. The results are divided into five sections. The first of these, Chapter 4, details the in vitro characterisation of carbon paste electrodes (CPEs) and a Pt-based electrode modified with a membrane, methyl methacrylate (Pt-MMA) and makes comparisons between these two types of electrodes for use in vivo. Following on from the in vitro characterisation chapter, Pt-MMA electrodes were fully characterised in vivo and comparisons were made with previously published CPE data detailed in Chapter 5. The development and standardisation of a metal-free electrode for use in conjunction with fMRI studies for the detection of brain tissue oxygen is presented in Chapter 6. The complete in vivo characterisation of the fully characterised fMRI compatible O2 electrode developed in the previous chapter is detailed in Chapter 7. Chapter 8 demonstrates and characterises the simultaneous recording of oxygen and glucose using CPEs and a Pt-based glucose biosensor (Pt/PPD/GOx) in the hippocampus of freely-moving animals, and utilises these sensors to monitor brain energy metabolism in conjunction with a behavioural task. Finally, overall conclusions in relation to the work presented in this thesis are discussed in Chapter 9.

Subjects/Keywords: Brain energy metabolism; novel live methodologies

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bennett, R. (2012). Brain energy metabolism: development and application of novel live methodologies. (Thesis). RIAN. Retrieved from http://eprints.maynoothuniversity.ie/6698/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bennett, Rachel. “Brain energy metabolism: development and application of novel live methodologies.” 2012. Thesis, RIAN. Accessed March 06, 2021. http://eprints.maynoothuniversity.ie/6698/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bennett, Rachel. “Brain energy metabolism: development and application of novel live methodologies.” 2012. Web. 06 Mar 2021.

Vancouver:

Bennett R. Brain energy metabolism: development and application of novel live methodologies. [Internet] [Thesis]. RIAN; 2012. [cited 2021 Mar 06]. Available from: http://eprints.maynoothuniversity.ie/6698/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bennett R. Brain energy metabolism: development and application of novel live methodologies. [Thesis]. RIAN; 2012. Available from: http://eprints.maynoothuniversity.ie/6698/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana State University

16. Hunt, Kristopher Allen. The stoichiometry of nutrient and energy transfer: from organelles to organisms.

Degree: PhD, College of Engineering, 2016, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/14626

► All life requires the acquisition and transformation of nutrients and energy, driving processes from cellular nutrient flow to planetary biogeochemical cycling. However, the organisms and… (more)

Subjects/Keywords: Microorganisms.; Biomass energy.; Metabolism.; Stoichiometry.; Systems biology.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hunt, K. A. (2016). The stoichiometry of nutrient and energy transfer: from organelles to organisms. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/14626

Chicago Manual of Style (16^th Edition):

Hunt, Kristopher Allen. “The stoichiometry of nutrient and energy transfer: from organelles to organisms.” 2016. Doctoral Dissertation, Montana State University. Accessed March 06, 2021. https://scholarworks.montana.edu/xmlui/handle/1/14626.

MLA Handbook (7^th Edition):

Hunt, Kristopher Allen. “The stoichiometry of nutrient and energy transfer: from organelles to organisms.” 2016. Web. 06 Mar 2021.

Vancouver:

Hunt KA. The stoichiometry of nutrient and energy transfer: from organelles to organisms. [Internet] [Doctoral dissertation]. Montana State University; 2016. [cited 2021 Mar 06]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/14626.

Council of Science Editors:

Hunt KA. The stoichiometry of nutrient and energy transfer: from organelles to organisms. [Doctoral Dissertation]. Montana State University; 2016. Available from: https://scholarworks.montana.edu/xmlui/handle/1/14626

University of Melbourne

17. Thomas, Natalie Paige. Investigating potential subgroups within the schizophrenias: a study of cholinergic muscarinic receptor density and energy metabolism.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/58776

► Background. A crucial step towards understanding the aetiology of schizophrenia (SCZ), and developing more effective diagnostic methods and treatments is to identify and characterise potential… (more)

▼ Background. A crucial step towards understanding the aetiology of schizophrenia (SCZ), and developing more effective diagnostic methods and treatments is to identify and characterise potential subgroups within the diagnosis. There is growing evidence to support the existence of biologically discrete subgroups; one such demonstration is a subgroup denoted muscarinic receptor deficient schizophrenia (MRDS). Making up 25% of the SCZ population, these subjects are separated due to their marked loss (75%) in [3H] pirenzepine binding (cholinergic muscarinic M1 receptor preferring ligand), measured in the dorsolateral prefrontal cortex (DLPFC) in post-mortem brain tissue. Having established the SCZMRDS subgroup in our laboratory, we have the ability to investigate the pathophysiology that presents within this discrete subgroup. Study 1. Previous reports suggest lower [3H] pirenzepine and [3H] AF-DX 384 (muscarinic M2/ M4 receptor preferring ligand) binding in the caudate putamen (C.Pu) in SCZ subjects. However, it is not known if SCZMRDS subjects drive this decreased binding in the C.Pu, as they do in cortical regions. Therefore, to better understand the changes in muscarinic receptors in the C.Pu from SCZ subjects, and to delineate whether the SCZMRDS subgroup was identifiable in subcortical regions, we measured [3H] pirenzepine and [3H] AF-DX 384, and [3H] 4’DAMP binding in C.Pu from 40 SCZ subjects, 20 of which were SCZMRDS, 20 that were MRDSNON-MRDS, and 20 non-psychiatric controls (CTRL). These measures gave good estimation of muscarinic M1 receptor (CHRM1), CHRM2/4, and CHRM3 receptor levels, respectively. The level of [3H] pirenzepine binding was significantly lower in the C.Pu from subjects with SCZ when compared to CTRL (p < 0.0007). This was driven by the SCZMRDS group (p < 0.0001 relative to CTRL). The levels of [3H] AF-DX 384 binding was significantly lower in the C.Pu from SCZ subjects compared to CTRL (p < 0.0001); this was demonstrated more strongly in SCZMRDS subjects (p < 0.0001) than SCZNON-MRDS subjects (p < 0.001) when compared to CTRL subjects. No significant differences in [3H] 4’DAMP measures were shown. Collectively, the results demonstrated that the SCZMRDS subgroup had significantly different CHRM density profiles within the striatum, when compared to SCZNON-MRDS and CTRLS. These results reinforce the idea that SCZMRDS and SCZNON-MRDS cohorts are biochemically distinct with regards to CHRM biology. Within the cortex, reductions in CHRM density were observed predominately within the SCZMRDS cohort for all binding densities measured. Within the striatum however, reductions of [3H] AF-DX 384 binding were observed in both SCZMRDS and SCZNONMRDS subjects compared to CTRLS. This suggests that in terms of CHRM density, the striatum is more complicated compared to the cortex. As CHRM1/4 agonist therapy represents a promising approach for treatment of both the positive and cognitive symptoms in people with schizophrenia, these results characterising discrete subgroups with regards to CHRM density…

Subjects/Keywords: schizophrenia; molecular psychiatry; cholinergic; energy metabolism; subgroups

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thomas, N. P. (2016). Investigating potential subgroups within the schizophrenias: a study of cholinergic muscarinic receptor density and energy metabolism. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/58776

Chicago Manual of Style (16^th Edition):

Thomas, Natalie Paige. “Investigating potential subgroups within the schizophrenias: a study of cholinergic muscarinic receptor density and energy metabolism.” 2016. Doctoral Dissertation, University of Melbourne. Accessed March 06, 2021. http://hdl.handle.net/11343/58776.

MLA Handbook (7^th Edition):

Thomas, Natalie Paige. “Investigating potential subgroups within the schizophrenias: a study of cholinergic muscarinic receptor density and energy metabolism.” 2016. Web. 06 Mar 2021.

Vancouver:

Thomas NP. Investigating potential subgroups within the schizophrenias: a study of cholinergic muscarinic receptor density and energy metabolism. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/11343/58776.

Council of Science Editors:

Thomas NP. Investigating potential subgroups within the schizophrenias: a study of cholinergic muscarinic receptor density and energy metabolism. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/58776

18. Bennett, Rachel. Brain energy metabolism: development and application of novel live methodologies.

Degree: 2012, RIAN

URL: http://mural.maynoothuniversity.ie/6698/

► This thesis investigates methods of studying brain energy metabolism with a specific focus on the substrates oxygen and glucose. It details the in vitro development… (more)

▼ This thesis investigates methods of studying brain energy metabolism with a specific focus on the substrates oxygen and glucose. It details the in vitro development and in vivo characterisation of microelectrochemical sensors for the detection of brain tissue oxygen, and the in vivo characterisation of oxygen and glucose electrodes in the hippocampus utilising the technique of long-term in vivo electrochemistry (LIVE). Chapter 1 introduces the brain, energy metabolism and neurochemical analysis focusing on oxygen and glucose monitoring in the brain. Chapter 2 discusses the theory relevant to the studies performed in this work, whilst Chapter 3 is a detailed description of sensor construction and techniques used for the in vivo and in vitro characterisation of the sensors utilised in this thesis. The results are divided into five sections. The first of these, Chapter 4, details the in vitro characterisation of carbon paste electrodes (CPEs) and a Pt-based electrode modified with a membrane, methyl methacrylate (Pt-MMA) and makes comparisons between these two types of electrodes for use in vivo. Following on from the in vitro characterisation chapter, Pt-MMA electrodes were fully characterised in vivo and comparisons were made with previously published CPE data detailed in Chapter 5. The development and standardisation of a metal-free electrode for use in conjunction with fMRI studies for the detection of brain tissue oxygen is presented in Chapter 6. The complete in vivo characterisation of the fully characterised fMRI compatible O2 electrode developed in the previous chapter is detailed in Chapter 7. Chapter 8 demonstrates and characterises the simultaneous recording of oxygen and glucose using CPEs and a Pt-based glucose biosensor (Pt/PPD/GOx) in the hippocampus of freely-moving animals, and utilises these sensors to monitor brain energy metabolism in conjunction with a behavioural task. Finally, overall conclusions in relation to the work presented in this thesis are discussed in Chapter 9.

Subjects/Keywords: Brain energy metabolism; novel live methodologies

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bennett, R. (2012). Brain energy metabolism: development and application of novel live methodologies. (Thesis). RIAN. Retrieved from http://mural.maynoothuniversity.ie/6698/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bennett, Rachel. “Brain energy metabolism: development and application of novel live methodologies.” 2012. Thesis, RIAN. Accessed March 06, 2021. http://mural.maynoothuniversity.ie/6698/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bennett, Rachel. “Brain energy metabolism: development and application of novel live methodologies.” 2012. Web. 06 Mar 2021.

Vancouver:

Bennett R. Brain energy metabolism: development and application of novel live methodologies. [Internet] [Thesis]. RIAN; 2012. [cited 2021 Mar 06]. Available from: http://mural.maynoothuniversity.ie/6698/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bennett R. Brain energy metabolism: development and application of novel live methodologies. [Thesis]. RIAN; 2012. Available from: http://mural.maynoothuniversity.ie/6698/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

19. Xu, Cheng. Role of adipose SIRT1 in regulating systemic energy metabolism.

Degree: 2013, University of Hong Kong

URL: http://hdl.handle.net/10722/183054

► SIRT1 (sirtuin 1), a mammalian ortholog of the longevity regulator yeast Sir2p, elicits diversified functions by mediating NAD+ -dependent deacetylation of protein targets. SIRT1 contributes… (more)

▼ SIRT1 (sirtuin 1), a mammalian ortholog of the longevity regulator yeast Sir2p, elicits diversified functions by mediating NAD+ -dependent deacetylation of protein targets. SIRT1 contributes to the beneficial effects of calorie restriction, the non-genetic intervention capable of promoting longevity and reducing the incidence of age-related disorders. In mammals, SIRT1 acts as a metabolic regulator in response to environmental stress signals. Activation of SIRT1 protects mice against diet-induced obesity and insulin resistance. However, the tissue specific metabolic functions of SIRT1 remain to be defined. The present study shows that over-expression of human SIRT1 selectively in adipose tissue decreases circulating lipid levels, reduces whole body fat mass, and elevates systemic insulin sensitivity. By contrast, over-expression of a dominant-negative human SIRT1 mutant H363Y in adipose tissue accelerates the development of aging-associated insulin resistance. Activation or down-regulation of adipose SIRT1 promotes lipid mobilization towards different metabolic organs and alters biotin homeostasis in opposite manners. Adipose SIRT1 positively regulates lipid metabolism, genes expression and adipokines secretion which are negatively influenced by SIRT1 H363Y mutant. Biotin is a water soluble vitamin and plays an important role in energy metabolism. The present study shows that biotin and its metabolites are the endogenous inhibitors of SIRT1 enzymatic activity. Chronic biotin supplementation abolishes adipose SIRT1-mediated beneficial effects on lipid metabolism. These effects are partly explained by the regulation of acetyl-CoA carboxylase (ACC), a key regulator of lipid metabolism and biotin homeostasis. SIRT1 selectively deacetylates and negatively regulate the protein stability of ACC. Over-expression of SIRT1 in fat cells persistently down-regulates ACC expression. The direct interaction between SIRT1 and ACC are subjected to rapid regulation by nutrient status which can explain the beneficial effect of SIRT1 in energy homeostasis. In mice subjected to chronic treatment with biotin, the interactions between SIRT1 and ACC were significantly inhibited. Taken in conjunction, the above findings reveal that SIRT1 in adipose tissue functions to regulate systemic energy metabolism and insulin sensitivity. In particular, it plays a critical role in modulating ACC protein levels and biotin homeostasis in adipose tissue, which in turn facilitate lipid storage and utilization in response to nutrient level changes. Advisors/Committee Members: Wang, Y (advisor), Vanhoutte, PMGR (advisor).

Subjects/Keywords: Sirtuins.; Energy metabolism.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xu, C. (2013). Role of adipose SIRT1 in regulating systemic energy metabolism. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/183054

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xu, Cheng. “Role of adipose SIRT1 in regulating systemic energy metabolism.” 2013. Thesis, University of Hong Kong. Accessed March 06, 2021. http://hdl.handle.net/10722/183054.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xu, Cheng. “Role of adipose SIRT1 in regulating systemic energy metabolism.” 2013. Web. 06 Mar 2021.

Vancouver:

Xu C. Role of adipose SIRT1 in regulating systemic energy metabolism. [Internet] [Thesis]. University of Hong Kong; 2013. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10722/183054.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xu C. Role of adipose SIRT1 in regulating systemic energy metabolism. [Thesis]. University of Hong Kong; 2013. Available from: http://hdl.handle.net/10722/183054

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

20. Reznick, Jane. Circadian regulation of energy metabolism.

Degree: Biotechnology & Biomolecular Sciences, 2011, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/51633 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10300/SOURCE02?view=true

► All cells possess a molecular circadian “clock” thought to coordinate various aspects of the physiology and behaviour of an animal with the light/dark cycle of… (more)

▼ All cells possess a molecular circadian “clock” thought to coordinate various aspects of the physiology and behaviour of an animal with the light/dark cycle of the external world. Light is the principle cue entraining molecular clocks via the suprachiasmatic nucleus of the brain. Recent evidence however, has also implicated food-borne signals as external stimuli capable of resetting clocks in the periphery. The aim of this thesis was to investigate the impact of aberrant feeding on circadian energy metabolism in the rat by feeding a high fat diet and restricting feeding to the daylight hours (rats normally feed only at night). Rats on the daylight feeding schedule displayed various differences in metabolism. In the liver the circadian expression pattern of molecular clock genes was completely reversed in response to the new feeding schedule. In contrast, circadian gene expression in muscle remained similar to an animal feeding ad libitum. This asynchrony in circadian gene expression in two metabolically relevant tissues was accompanied by loss of diurnal variation and a reduction in energy expenditure, and increased muscle glycogen in the day-fed rats. The second aim of this thesis was to determine how the core molecular clock relays temporal regulation to downstream functional genes in tissues. In vivo electroporation and hydrodynamic tail vein injection were employed to overexpress the clock output factor DBP in muscle and liver respectively. Using microarray and gene enrichment analysis the data shows that DBP regulates genes of cholesterol efflux which remove excess lipid in muscle and in the liver DBP upregulates genes of bile acid synthesis for the conversion of cholesterol for its elimination. Somewhat surprisingly, the specific genes upregulated by DBP in the two tissues were different. This suggested that DBP has tissue-specific targets but with an overall conserved role to regulate the removal of excess lipids. The data in this thesis confirms the involvement of the circadian system in the regulation of important metabolic pathways and highlights the potential impact on metabolism if the tissue circadian rhythms become misaligned with the light/dark cycle. Advisors/Committee Members: Cooney, Gregory, Garvan Institute of Medical Research, Turner, Nigel, Garvan Institute of Medical Research.

Subjects/Keywords: PARbZIP transcriptional factors; Circadian rhythms; Energy metabolism

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APA (6^th Edition):

Reznick, J. (2011). Circadian regulation of energy metabolism. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/51633 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10300/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Reznick, Jane. “Circadian regulation of energy metabolism.” 2011. Doctoral Dissertation, University of New South Wales. Accessed March 06, 2021. http://handle.unsw.edu.au/1959.4/51633 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10300/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Reznick, Jane. “Circadian regulation of energy metabolism.” 2011. Web. 06 Mar 2021.

Vancouver:

Reznick J. Circadian regulation of energy metabolism. [Internet] [Doctoral dissertation]. University of New South Wales; 2011. [cited 2021 Mar 06]. Available from: http://handle.unsw.edu.au/1959.4/51633 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10300/SOURCE02?view=true.

Council of Science Editors:

Reznick J. Circadian regulation of energy metabolism. [Doctoral Dissertation]. University of New South Wales; 2011. Available from: http://handle.unsw.edu.au/1959.4/51633 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10300/SOURCE02?view=true

Michigan State University

21. Granett, Sandra Elizabeth Spieker, 1945-. Energy metabolism in phenylketonuric models : relevance as a mechanism for phenylalanine toxicity.

Degree: MS, Dept. of Biochemistry, 1970, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:15031

Subjects/Keywords: Energy metabolism; Phenylketonuria

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APA (6^th Edition):

Granett, Sandra Elizabeth Spieker, 1. (1970). Energy metabolism in phenylketonuric models : relevance as a mechanism for phenylalanine toxicity. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:15031

Chicago Manual of Style (16^th Edition):

Granett, Sandra Elizabeth Spieker, 1945-. “Energy metabolism in phenylketonuric models : relevance as a mechanism for phenylalanine toxicity.” 1970. Masters Thesis, Michigan State University. Accessed March 06, 2021. http://etd.lib.msu.edu/islandora/object/etd:15031.

MLA Handbook (7^th Edition):

Granett, Sandra Elizabeth Spieker, 1945-. “Energy metabolism in phenylketonuric models : relevance as a mechanism for phenylalanine toxicity.” 1970. Web. 06 Mar 2021.

Vancouver:

Granett, Sandra Elizabeth Spieker 1. Energy metabolism in phenylketonuric models : relevance as a mechanism for phenylalanine toxicity. [Internet] [Masters thesis]. Michigan State University; 1970. [cited 2021 Mar 06]. Available from: http://etd.lib.msu.edu/islandora/object/etd:15031.

Council of Science Editors:

Granett, Sandra Elizabeth Spieker 1. Energy metabolism in phenylketonuric models : relevance as a mechanism for phenylalanine toxicity. [Masters Thesis]. Michigan State University; 1970. Available from: http://etd.lib.msu.edu/islandora/object/etd:15031

The Ohio State University

22. Cal, Jimmie L. The effects of interval bench stepping on the metabolic energy mechanisms.

Degree: PhD, Graduate School, 1973, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486744174937634

Subjects/Keywords: Education; Energy metabolism

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APA (6^th Edition):

Cal, J. L. (1973). The effects of interval bench stepping on the metabolic energy mechanisms. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486744174937634

Chicago Manual of Style (16^th Edition):

Cal, Jimmie L. “The effects of interval bench stepping on the metabolic energy mechanisms.” 1973. Doctoral Dissertation, The Ohio State University. Accessed March 06, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486744174937634.

MLA Handbook (7^th Edition):

Cal, Jimmie L. “The effects of interval bench stepping on the metabolic energy mechanisms.” 1973. Web. 06 Mar 2021.

Vancouver:

Cal JL. The effects of interval bench stepping on the metabolic energy mechanisms. [Internet] [Doctoral dissertation]. The Ohio State University; 1973. [cited 2021 Mar 06]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486744174937634.

Council of Science Editors:

Cal JL. The effects of interval bench stepping on the metabolic energy mechanisms. [Doctoral Dissertation]. The Ohio State University; 1973. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486744174937634

Virginia Tech

23. Luo, Jing. Exploring the metabolic role of GPR30 in mice.

Degree: PhD, Human Nutrition, Foods, and Exercise, 2019, Virginia Tech

URL: http://hdl.handle.net/10919/101091

► Recent studies showed that GPR30, a seven-transmembrane G protein-coupled receptor, is a novel estrogen receptor (ER) that mediates some biological events elicited by estrogen in… (more)

▼ Recent studies showed that GPR30, a seven-transmembrane G protein-coupled receptor, is a novel estrogen receptor (ER) that mediates some biological events elicited by estrogen in several types of cancer cells. However, its physiological or pathological role in vivo is unclear. For the first project of my dissertation, I investigated the physiological role(s) of GPR30 in energy metabolism by using transgenic mouse model as well as immortalized cell lines and primary stromal cells. We discovered for the first time that GPR30 knockout (GPRKO) female mice were protected from high-fat diet (HFD)-induced obesity, glucose intolerance, and insulin resistance. The decreased body weight gain in GPRKO female mice is due to the reduction in body fat mass. These effects occurred in the absence of significant changes in food intake, intestinal fat absorption, or triglyceride metabolism. However, GPR30 had no significant metabolic effects in male mice fed the HFD and both sexes of mice fed a chow diet. Further, GPR30 expression levels in fat tissues of WT obese female mice greatly increased, whereas ERα/β expression was not altered. Deletion of GPR30 reduced adipogenic differentiation of adipose tissue-derived stromal cells. Conversely, activation of GPR30 enhanced adipogenic differentiation of 3T3-L1 preadipocytes. For the second project, I explored whether estrogen acts through GPR30 to affect adiposity in female mice. For this study, I generated and examined three independent transgenic mouse models, aromatase (Ar) knockout (ArKO) mice, GPRKO, and GPR30 and Ar double knockout (DKO) mice. We discovered that GPR30 deficiency had limited effects on energy metabolism in mice fed a standard chow diet (STD). However, deletion of GPR30 promoted metabolic flexibility in both genders fed a HFD regardless of the presence of estrogen, suggesting that GPR30 may not solely act as an ER. Consistent with our previous findings, GPRKO mice had higher body temperature, indicating that GPR30 deficiency may promote thermogenesis and energy metabolism, resulting in the reduced fat depots and enhanced metabolic flexibility. For the third project, I further explored whether GPR30 is involved in regulating browning of adipose tissue and thermogenesis in mice. The results show that the expression of UCP-1, the key regulator of thermogenic browning, was higher in the adipose tissue of HFD-fed GPRKO female mice as compared with that of WT mice. Consistently, deletion of GPR30 enhanced mitochondrial respiration in brown adipose tissue (BAT), suggesting that GPR30 deficiency at least partially suppressed the fat accumulation by promoting thermogenesis and dissipating energy. Ex vivo, the expression of thermogenic genes and UCP-1 protein level were upregulated in beige adipocytes differentiated from GPR30-deficient stromal vascular fraction (SVF) cells. These findings provide evidence for the first time that deletion of GPR30 reduces adiposity, promotes white adipose beigeing and thermogenesis, therefore preventing the development of obesity in female… Advisors/Committee Members: Liu, Dongmin (committeechair), Ju, Young Hwa (committee member), Gilbert, Elizabeth Ruth (committee member), Hulver, Matthew Wade (committee member), Cheng, Zhiyong (committee member).

Subjects/Keywords: GPR30; estrogen; obesity; energy metabolism; browning

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APA (6^th Edition):

Luo, J. (2019). Exploring the metabolic role of GPR30 in mice. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/101091

Chicago Manual of Style (16^th Edition):

Luo, Jing. “Exploring the metabolic role of GPR30 in mice.” 2019. Doctoral Dissertation, Virginia Tech. Accessed March 06, 2021. http://hdl.handle.net/10919/101091.

MLA Handbook (7^th Edition):

Luo, Jing. “Exploring the metabolic role of GPR30 in mice.” 2019. Web. 06 Mar 2021.

Vancouver:

Luo J. Exploring the metabolic role of GPR30 in mice. [Internet] [Doctoral dissertation]. Virginia Tech; 2019. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10919/101091.

Council of Science Editors:

Luo J. Exploring the metabolic role of GPR30 in mice. [Doctoral Dissertation]. Virginia Tech; 2019. Available from: http://hdl.handle.net/10919/101091

Massey University

24. Hayman, Ann. The effect of synthetic and bovine conjugated linoleic acid on energy balance.

Degree: MS, Nutritional Science, 1999, Massey University

URL: http://hdl.handle.net/10179/12392

► Conjugated linoleic acid (CLA) is biologically active and has altered body composition in experimental animals. Dietary supplementation with synthetic CLA reduced body fat in mice… (more)

Subjects/Keywords: Linoleic acid – Metabolism; Energy metabolism

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APA (6^th Edition):

Hayman, A. (1999). The effect of synthetic and bovine conjugated linoleic acid on energy balance. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/12392

Chicago Manual of Style (16^th Edition):

Hayman, Ann. “The effect of synthetic and bovine conjugated linoleic acid on energy balance.” 1999. Masters Thesis, Massey University. Accessed March 06, 2021. http://hdl.handle.net/10179/12392.

MLA Handbook (7^th Edition):

Hayman, Ann. “The effect of synthetic and bovine conjugated linoleic acid on energy balance.” 1999. Web. 06 Mar 2021.

Vancouver:

Hayman A. The effect of synthetic and bovine conjugated linoleic acid on energy balance. [Internet] [Masters thesis]. Massey University; 1999. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10179/12392.

Council of Science Editors:

Hayman A. The effect of synthetic and bovine conjugated linoleic acid on energy balance. [Masters Thesis]. Massey University; 1999. Available from: http://hdl.handle.net/10179/12392

Stellenbosch University

25. Strydom, Adel. Understanding household energy metabolism in the city of Cape Town.

Degree: MPhil, 2019, Stellenbosch University

URL: http://hdl.handle.net/10019.1/105607

ENGLISH SUMMARY :

AFRIKAANSE OPSOMMING : Geen opsomming beskikbaar.

Masters

Advisors/Committee Members: Musango, Josephine Kaviti, Currie, Paul Klugman, Stellenbosch University. Faculty of Economic and Management Sciences. School of Public Leadership..

Subjects/Keywords: Urban metabolism, energy metabolism, household metabolism, household energy consumption, energy access; energy metabolism; household metabolism; household energy consumption; energy access; UCTD

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APA (6^th Edition):

Strydom, A. (2019). Understanding household energy metabolism in the city of Cape Town. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/105607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Strydom, Adel. “Understanding household energy metabolism in the city of Cape Town.” 2019. Thesis, Stellenbosch University. Accessed March 06, 2021. http://hdl.handle.net/10019.1/105607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Strydom, Adel. “Understanding household energy metabolism in the city of Cape Town.” 2019. Web. 06 Mar 2021.

Vancouver:

Strydom A. Understanding household energy metabolism in the city of Cape Town. [Internet] [Thesis]. Stellenbosch University; 2019. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10019.1/105607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Strydom A. Understanding household energy metabolism in the city of Cape Town. [Thesis]. Stellenbosch University; 2019. Available from: http://hdl.handle.net/10019.1/105607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

26. Soares, Gabriela Moreira, 1991-. Participação da ARHGAP21 na regulação da homeostase glicêmica e energética de camundongos C57BL/6 : Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice: Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice.

Degree: 2019, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334037

► Abstract: Obesity and type 2 diabetes mellitus have been growing considerably worldwide, mainly due to changes in lifestyle and increased consumption of hypercaloric diets. These… (more)

▼ Abstract: Obesity and type 2 diabetes mellitus have been growing considerably worldwide, mainly due to changes in lifestyle and increased consumption of hypercaloric diets. These diseases are associated with impairment in glucose and energy metabolism, both in humans and animal experimental models. Therefore, several proteins that can modulate glycemic and energetic metabolism have been investigated in order to elucidate possible targets to therapeutic treatment of these diseases, among which there are the GTPase activating proteins (GAPs). GAPs regulate the activity of small G proteins, usually, accelerating their inactivation process through the induction of GTP hydrolysis. Recently the Rho-GAPs have been explored in the metabolic context, and the knockdown of the Rho-GAP ARHGAP21 in neonate¿s pancreatic islets induces increased insulin secretion in low glucose concentration. However, the role of ARHGAP21 in glycemic and energetic homeostasis remains unclear. Thus, we aimed to evaluate the role of ARHGAP21 on metabolism regulation. To achieve this, wild C57BL/6 mice or knockdown for ARHGAP21 were fed with chow or high-fat diet for 10 weeks. As expected, wild-type mice that received high-fat diet presented glucose intolerance, insulin resistance, insulin hypersecretion, and increased body weight and fat depots. ARHGAP21 knockdown mice fed with high-fat diet were protected from the deleterious effects of the diet and did not present any of the above-mentioned alterations. In addition, we observed that ARHGAP21 knockdown mice presented increased POMC and CART gene expression, both anorexigenic hypothalamic genes. This data corroborates with decreased food consumption and increased energy expenditure of these mice. These findings highlight the Rho-GAP ARHGAP21 protein as an important modulator of energy and glucose metabolism, and a possible candidate for the treatment of alterations in glycemic and energetic homeostasis Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Barbosa-Sampaio, Helena Cristina, 1978- (advisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Funcional e Molecular (nameofprogram), Oliveira, Camila Aparecida Machado de (committee member), Bonfleur, Maria Lúcia (committee member), Balbo, Sandra Lucinei (committee member), Werneck, Claudio Chrysostomo (committee member).

Subjects/Keywords: Obesidade; Glicose - Metabolismo; Metabolismo energético; Gene ARHGAP21; Obesity; Glucose - Metabolism; Energy metabolism; ARHGAP21 gene

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APA (6^th Edition):

Soares, Gabriela Moreira, 1. (2019). Participação da ARHGAP21 na regulação da homeostase glicêmica e energética de camundongos C57BL/6 : Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice: Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/334037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Soares, Gabriela Moreira, 1991-. “Participação da ARHGAP21 na regulação da homeostase glicêmica e energética de camundongos C57BL/6 : Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice: Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice.” 2019. Thesis, Universidade Estadual de Campinas. Accessed March 06, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/334037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Soares, Gabriela Moreira, 1991-. “Participação da ARHGAP21 na regulação da homeostase glicêmica e energética de camundongos C57BL/6 : Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice: Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice.” 2019. Web. 06 Mar 2021.

Vancouver:

Soares, Gabriela Moreira 1. Participação da ARHGAP21 na regulação da homeostase glicêmica e energética de camundongos C57BL/6 : Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice: Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice. [Internet] [Thesis]. Universidade Estadual de Campinas; 2019. [cited 2021 Mar 06]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Soares, Gabriela Moreira 1. Participação da ARHGAP21 na regulação da homeostase glicêmica e energética de camundongos C57BL/6 : Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice: Role of ARHGAP21 in regulation of glucose and energy homeostasis in C57BL/6 mice. [Thesis]. Universidade Estadual de Campinas; 2019. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

27. Lindmark, Lars, 1950-. Energy metabolism : methodological, experimental and clinical investigations.

Degree: 1985, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/12681

Subjects/Keywords: Medicin Allmänt Energy metabolism; Neoplasms: metabolism

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APA (6^th Edition):

Lindmark, Lars, 1. (1985). Energy metabolism : methodological, experimental and clinical investigations. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/12681

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lindmark, Lars, 1950-. “Energy metabolism : methodological, experimental and clinical investigations.” 1985. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 06, 2021. http://hdl.handle.net/2077/12681.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lindmark, Lars, 1950-. “Energy metabolism : methodological, experimental and clinical investigations.” 1985. Web. 06 Mar 2021.

Vancouver:

Lindmark, Lars 1. Energy metabolism : methodological, experimental and clinical investigations. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1985. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2077/12681.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lindmark, Lars 1. Energy metabolism : methodological, experimental and clinical investigations. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1985. Available from: http://hdl.handle.net/2077/12681

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wilfrid Laurier University

28. Grisebach, Daniel; Bornath, Derek PD; Broad, Abigail A.; McCarthy, Seth F. Effects of an acute session of high- vs low-load resistance training exercise on energy balance.

Degree: 2020, Wilfrid Laurier University

URL: https://scholars.wlu.ca/etd/2321

► This study examined the effect of an acute session of low-load high-volume resistance training versus a more traditional high-load low-volume session on energy balance (EB).… (more)

Subjects/Keywords: Energy Balance; Metabolism; Post-Exercise Metabolism; Appetite; Appetite Suppression; Resistance Training; Exercise Science

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APA (6^th Edition):

Grisebach, Daniel; Bornath, Derek PD; Broad, Abigail A.; McCarthy, S. F. (2020). Effects of an acute session of high- vs low-load resistance training exercise on energy balance. (Thesis). Wilfrid Laurier University. Retrieved from https://scholars.wlu.ca/etd/2321

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grisebach, Daniel; Bornath, Derek PD; Broad, Abigail A.; McCarthy, Seth F. “Effects of an acute session of high- vs low-load resistance training exercise on energy balance.” 2020. Thesis, Wilfrid Laurier University. Accessed March 06, 2021. https://scholars.wlu.ca/etd/2321.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grisebach, Daniel; Bornath, Derek PD; Broad, Abigail A.; McCarthy, Seth F. “Effects of an acute session of high- vs low-load resistance training exercise on energy balance.” 2020. Web. 06 Mar 2021.

Vancouver:

Grisebach, Daniel; Bornath, Derek PD; Broad, Abigail A.; McCarthy SF. Effects of an acute session of high- vs low-load resistance training exercise on energy balance. [Internet] [Thesis]. Wilfrid Laurier University; 2020. [cited 2021 Mar 06]. Available from: https://scholars.wlu.ca/etd/2321.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grisebach, Daniel; Bornath, Derek PD; Broad, Abigail A.; McCarthy SF. Effects of an acute session of high- vs low-load resistance training exercise on energy balance. [Thesis]. Wilfrid Laurier University; 2020. Available from: https://scholars.wlu.ca/etd/2321

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

29. Husband, Thomas Paul, 1950-. Energy metabolism, nitrogen balance, and body composition of the fox squirrel (Sciurus niger).

Degree: MS, Dept. of Fisheries and Wildlife, 1974, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:15047

Subjects/Keywords: Fox squirrel; Energy metabolism; Nitrogen – Metabolism

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APA (6^th Edition):

Husband, Thomas Paul, 1. (1974). Energy metabolism, nitrogen balance, and body composition of the fox squirrel (Sciurus niger). (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:15047

Chicago Manual of Style (16^th Edition):

Husband, Thomas Paul, 1950-. “Energy metabolism, nitrogen balance, and body composition of the fox squirrel (Sciurus niger).” 1974. Masters Thesis, Michigan State University. Accessed March 06, 2021. http://etd.lib.msu.edu/islandora/object/etd:15047.

MLA Handbook (7^th Edition):

Husband, Thomas Paul, 1950-. “Energy metabolism, nitrogen balance, and body composition of the fox squirrel (Sciurus niger).” 1974. Web. 06 Mar 2021.

Vancouver:

Husband, Thomas Paul 1. Energy metabolism, nitrogen balance, and body composition of the fox squirrel (Sciurus niger). [Internet] [Masters thesis]. Michigan State University; 1974. [cited 2021 Mar 06]. Available from: http://etd.lib.msu.edu/islandora/object/etd:15047.

Council of Science Editors:

Husband, Thomas Paul 1. Energy metabolism, nitrogen balance, and body composition of the fox squirrel (Sciurus niger). [Masters Thesis]. Michigan State University; 1974. Available from: http://etd.lib.msu.edu/islandora/object/etd:15047

Michigan State University

30. Vismeh, Ramin. Multifaceted metabolomics approaches for characterization of lignocellulosic biomass degradation products formed during ammonia fiber expansion pretreatment.

Degree: 2012, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:596

►

Thesis Ph. D. Michigan State University. Chemistry 2012.

Lignocellulosic biomass represents a rather unused resource for production of biofuels, and it offers an alternative to… (more)

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Thesis Ph. D. Michigan State University. Chemistry 2012.

Lignocellulosic biomass represents a rather unused resource for production of biofuels, and it offers an alternative to food sources including corn starch. However, structural and compositional impediments limit the digestibility of sugar polymers in biomass cell walls. Thermochemical pretreatments improve accessibility of cellulose and hemicellulose to hydrolytic enzymes. However, most pretreatment methods generate compounds that either inhibit enzymatic hydrolysis or exhibit toxicity to fermentive microorganisms. Characterization and quantification of these products are essential for understanding chemistry of the pretreatment and optimizing the process efficiency to achieve higher ethanol yields. Identification of oligosaccharides released during pretreatment is also critical for choosing hydrolases necessary for cost-effective hydrolysis of cellulose and hemicellulose to fermentable monomeric sugars. Two chapters in this dissertation describe new mass spectrometry-based strategies for characterization and quantification of products that are formed during ammonia fiber expansion (AFEX) pretreatment of corn stover. Comparison of Liquid Chromatography Mass Spectrometry (LC/MS) profiles of AFEX-treated corn stover (AFEXTCS) and untreated corn stover (UTCS) extract shows that ammonolysis of lignin carbohydrate ester linkages generates a suite of nitrogenous compounds that are present only in the AFEXTCS extract and represent a loss of ammonia during processing. Several of these products including acetamide, feruloyl, coumaroyl and diferuloyl amides were characterized and quantified in the AFEXTCS extracts. The total amount of characterized and uncharacterized phenolic amides measured 17.4 mg/g AFEXTCS. Maillard reaction products including pyrazines and imidazoles were also identified and measured in the AFEXTCS extract totaling almost 1 mg/g AFEXTCS. The total of quantified nitrogenous products that are formed during AFEX was 43.4 mg/g AFEXTCS which was equivalent to 45-50 % of ammonia that is lost during the pretreatment. Methodology for identification, detection and quantification of various diferulate cross-linkers in forms of Di-Acids (Di-Ac), Acid-Amide (Ac-Am), and Di-Amides (Di-Am) in AFEX and NaOH treated corn stover using ultrahigh performance liquid chromatography/tandem mass spectrometry (LC/MS/MS) is presented. Characterization of isomeric diferulates was based on the distinguishing fragments formed upon collision induced dissociation (CID) of [M+H]+ ions of each diferulate isomer. LC separations combined with quasi-simultaneous acquisition of mass spectra at multiple collision energies provide fast spectrum acquisition using a time-of-flight (TOF) mass analyzer. This approach, called mux-CID, generates molecular and fragment ion mass information at different collision energies for molecular and adduct ions of oligosaccharides in a single analysis. Non-selective CID facilitated characterization of glucans and arabinoxylans in the AFEXTCS extracts.…

Advisors/Committee Members: Jones, Arthur Daniel, Bruening, Merlin, McGuffin, Victoria, Borhan, Babak.

Subjects/Keywords: Metabolism – Research; Lignocellulose – Biotechnology; Electrospray ionization mass spectrometry; Biomass energy; Analytical chemistry; Plant sciences; Energy

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APA (6^th Edition):

Vismeh, R. (2012). Multifaceted metabolomics approaches for characterization of lignocellulosic biomass degradation products formed during ammonia fiber expansion pretreatment. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:596

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vismeh, Ramin. “Multifaceted metabolomics approaches for characterization of lignocellulosic biomass degradation products formed during ammonia fiber expansion pretreatment.” 2012. Thesis, Michigan State University. Accessed March 06, 2021. http://etd.lib.msu.edu/islandora/object/etd:596.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vismeh, Ramin. “Multifaceted metabolomics approaches for characterization of lignocellulosic biomass degradation products formed during ammonia fiber expansion pretreatment.” 2012. Web. 06 Mar 2021.

Vancouver:

Vismeh R. Multifaceted metabolomics approaches for characterization of lignocellulosic biomass degradation products formed during ammonia fiber expansion pretreatment. [Internet] [Thesis]. Michigan State University; 2012. [cited 2021 Mar 06]. Available from: http://etd.lib.msu.edu/islandora/object/etd:596.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vismeh R. Multifaceted metabolomics approaches for characterization of lignocellulosic biomass degradation products formed during ammonia fiber expansion pretreatment. [Thesis]. Michigan State University; 2012. Available from: http://etd.lib.msu.edu/islandora/object/etd:596

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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