subject:( Deep vein trombosis)

Universidad de Salamanca

1. Persson Martín, Carlos Iván. Aplicación de protocolos de profilaxis tromboembólica en un servicio de cirugía ortopédica y traumatología. Importancia de su cumplimiento en la gestión de los recursos sanitarios .

Degree: 2008, Universidad de Salamanca

URL: http://hdl.handle.net/10366/18112

Subjects/Keywords: Trombosis venosa; Embolia pulmonar; Profilaxis; Heparina; Deep vein trombosis; Pulmonary embolism; Prophilaxis; Heparin

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APA (6^th Edition):

Persson Martín, C. I. (2008). Aplicación de protocolos de profilaxis tromboembólica en un servicio de cirugía ortopédica y traumatología. Importancia de su cumplimiento en la gestión de los recursos sanitarios . (Thesis). Universidad de Salamanca. Retrieved from http://hdl.handle.net/10366/18112

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Persson Martín, Carlos Iván. “Aplicación de protocolos de profilaxis tromboembólica en un servicio de cirugía ortopédica y traumatología. Importancia de su cumplimiento en la gestión de los recursos sanitarios .” 2008. Thesis, Universidad de Salamanca. Accessed December 14, 2019. http://hdl.handle.net/10366/18112.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Persson Martín, Carlos Iván. “Aplicación de protocolos de profilaxis tromboembólica en un servicio de cirugía ortopédica y traumatología. Importancia de su cumplimiento en la gestión de los recursos sanitarios .” 2008. Web. 14 Dec 2019.

Vancouver:

Persson Martín CI. Aplicación de protocolos de profilaxis tromboembólica en un servicio de cirugía ortopédica y traumatología. Importancia de su cumplimiento en la gestión de los recursos sanitarios . [Internet] [Thesis]. Universidad de Salamanca; 2008. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10366/18112.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Persson Martín CI. Aplicación de protocolos de profilaxis tromboembólica en un servicio de cirugía ortopédica y traumatología. Importancia de su cumplimiento en la gestión de los recursos sanitarios . [Thesis]. Universidad de Salamanca; 2008. Available from: http://hdl.handle.net/10366/18112

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

2. Boonyawat, Kochawan. A SURVEY OF THROMBOSIS SPECIALISTS ON THE PRACTICAL MANAGEMENT OF EXTENSIVE DEEP VEIN THROMBOSIS AND A PROTOCOL FOR A RANDOMIZED TRIAL.

Degree: MSc, 2017, McMaster University

URL: http://hdl.handle.net/11375/22219

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BACKGROUND: Though direct oral anticoagulants (DOACs) have become a standard of care in the treatment of acute deep vein thrombosis (DVT), it is our observation… (more)

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BACKGROUND: Though direct oral anticoagulants (DOACs) have become a standard of care in the treatment of acute deep vein thrombosis (DVT), it is our observation that physicians tend to initiate heparin or low-molecular-weight heparin, hereafter called “heparin”, for the treatment of extensive DVT or phlegmasia cerulea dolens (PCD). This might be due to a perception that heparin might relieve DVT-related symptoms more quickly than DOACs. Whether these assumptions are true has not been evaluated. METHODS: We conducted a survey of thrombosis specialists in North America to explore the practical management of anticoagulant therapy in patients with extensive DVT, and the underlying reasons for the selection of heparin over DOACs. A cross-sectional, web-based survey was distributed to thrombosis specialists who are members of four thrombosis societies. RESULTS: Eighty-nine respondents provided consent. Most respondents selected DOACs over heparin in a case scenario representing mild DVT-related symptoms and limited thrombus involvement (81% vs. 19%). Most respondents selected heparin over DOACs in a case scenario representing early stage PCD (84% vs.16.3%) or a patient with high bodyweight (72% vs. 28%). In a case scenario representing extensive DVT, 57.4% of the respondents selected heparin, whereas, 42.6% selected DOACs. In the respondents who selected heparin over DOACs, the major reason was that heparin might relieve DVT-related symptoms more quickly because of its anti-inflammatory effects. DISCUSSION: Severity of DVT-related symptoms, thrombus extent, and bodyweight play a role in the selection of anticoagulant therapy. Despite a lack of evidence to support the hypothesis with respect to which anticoagulant is superior, most thrombosis specialists selected heparin over DOACs in patients with severe DVT-related symptoms and extensive thrombus involvement. Observation of variations in the selection of anticoagulant therapy for the treatment of extensive DVT also indicates that clinical trials in this patient population are needed.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Crowther, Mark, Health Research Methodology.

Subjects/Keywords: Survey; Extensive deep vein thrombosis

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APA (6^th Edition):

Boonyawat, K. (2017). A SURVEY OF THROMBOSIS SPECIALISTS ON THE PRACTICAL MANAGEMENT OF EXTENSIVE DEEP VEIN THROMBOSIS AND A PROTOCOL FOR A RANDOMIZED TRIAL. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/22219

Chicago Manual of Style (16^th Edition):

Boonyawat, Kochawan. “A SURVEY OF THROMBOSIS SPECIALISTS ON THE PRACTICAL MANAGEMENT OF EXTENSIVE DEEP VEIN THROMBOSIS AND A PROTOCOL FOR A RANDOMIZED TRIAL.” 2017. Masters Thesis, McMaster University. Accessed December 14, 2019. http://hdl.handle.net/11375/22219.

MLA Handbook (7^th Edition):

Boonyawat, Kochawan. “A SURVEY OF THROMBOSIS SPECIALISTS ON THE PRACTICAL MANAGEMENT OF EXTENSIVE DEEP VEIN THROMBOSIS AND A PROTOCOL FOR A RANDOMIZED TRIAL.” 2017. Web. 14 Dec 2019.

Vancouver:

Boonyawat K. A SURVEY OF THROMBOSIS SPECIALISTS ON THE PRACTICAL MANAGEMENT OF EXTENSIVE DEEP VEIN THROMBOSIS AND A PROTOCOL FOR A RANDOMIZED TRIAL. [Internet] [Masters thesis]. McMaster University; 2017. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/11375/22219.

Council of Science Editors:

Boonyawat K. A SURVEY OF THROMBOSIS SPECIALISTS ON THE PRACTICAL MANAGEMENT OF EXTENSIVE DEEP VEIN THROMBOSIS AND A PROTOCOL FOR A RANDOMIZED TRIAL. [Masters Thesis]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/22219

3. Jara Palomares, Luís José. Estudio de seguimiento de pacientes consecutivos diagnosticados de embolismo pulmonar (EP).

Degree: 2009, Universidad de Sevilla

URL: http://hdl.handle.net/11441/55049

► La enfermedad tromboembólica venosa (ETEV) es una entidad constituida por la trombosis venosa profunda (TVP) y por el embolismo pulmonar (EP) (producido como consecuencia de… (more)

Subjects/Keywords: Trombosis

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APA (6^th Edition):

Jara Palomares, L. J. (2009). Estudio de seguimiento de pacientes consecutivos diagnosticados de embolismo pulmonar (EP). (Thesis). Universidad de Sevilla. Retrieved from http://hdl.handle.net/11441/55049

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jara Palomares, Luís José. “Estudio de seguimiento de pacientes consecutivos diagnosticados de embolismo pulmonar (EP).” 2009. Thesis, Universidad de Sevilla. Accessed December 14, 2019. http://hdl.handle.net/11441/55049.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jara Palomares, Luís José. “Estudio de seguimiento de pacientes consecutivos diagnosticados de embolismo pulmonar (EP).” 2009. Web. 14 Dec 2019.

Vancouver:

Jara Palomares LJ. Estudio de seguimiento de pacientes consecutivos diagnosticados de embolismo pulmonar (EP). [Internet] [Thesis]. Universidad de Sevilla; 2009. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/11441/55049.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jara Palomares LJ. Estudio de seguimiento de pacientes consecutivos diagnosticados de embolismo pulmonar (EP). [Thesis]. Universidad de Sevilla; 2009. Available from: http://hdl.handle.net/11441/55049

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

4. Midha, Prem Anand. Long-term patency of a polymer vein valve.

Degree: MS, Bioengineering, 2009, Georgia Tech

URL: http://hdl.handle.net/1853/29721

► Chronic Venous Insufficiency (CVI) is a condition in present in almost 27% of adults in which an insufficient amount of blood is pumped back to… (more)

Subjects/Keywords: Vein valve; Deep vein thrombosis; Venous valve; Prosthetic vein valve; Chronic venous insufficiency; Venous valves; Hemodynamics; Implants, Artificial; Veins

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APA (6^th Edition):

Midha, P. A. (2009). Long-term patency of a polymer vein valve. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/29721

Chicago Manual of Style (16^th Edition):

Midha, Prem Anand. “Long-term patency of a polymer vein valve.” 2009. Masters Thesis, Georgia Tech. Accessed December 14, 2019. http://hdl.handle.net/1853/29721.

MLA Handbook (7^th Edition):

Midha, Prem Anand. “Long-term patency of a polymer vein valve.” 2009. Web. 14 Dec 2019.

Vancouver:

Midha PA. Long-term patency of a polymer vein valve. [Internet] [Masters thesis]. Georgia Tech; 2009. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/1853/29721.

Council of Science Editors:

Midha PA. Long-term patency of a polymer vein valve. [Masters Thesis]. Georgia Tech; 2009. Available from: http://hdl.handle.net/1853/29721

5. Anjali Basnyat Bista. Aspiration Thrombectomy as the Sole Treatment for Acute and Sub-acute Deep Venous Thrombosis (DVT) of the Lower Extremity: mid and long-term clinical results.

Degree: 2012, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/7579 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012199

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Purpose: To determine the feasibility of aspiration thrombectomy as the sole treatment for acute and sub-acute deep vein thrombosis of the lower extremity by evaluating… (more)

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Purpose: To determine the feasibility of aspiration thrombectomy as the sole treatment for acute and sub-acute deep vein thrombosis of the lower extremity by evaluating the mid and long-term clinical results of aspiration thrombectomy treatment. Patients and methods: During a five year period (2005-2010), 108 patients with acute and sub-acute DVT of the lower-extremity underwent aspiration thrombectomy with 9-10 guiding catheters, after insertion of a temporary inferior vena cava (IVC) filter. The inclusion criteria were patients with acute or sub-acute iliofemoral or femoropopliteal DVT of less than 4 weeks duration, with or without IVC extension. If post procedure venography demonstrated persistent stenosis or residual thrombosis, adjunctive therapy was performed by balloon angioplasty, or stent placement. The aspirate was filtered and the amount of aspirated blood separated from the clot was measured. Adjuvant thrombolysis with urokinase was performed when the aspirated blood was over 400 ml or when the aspiration thrombectomy was incomplete. Results: Anatomical success was achieved in 92/108 (85%) patients after aspiration thrombectomy treatment of the thrombosed veins. In 16 patients with residual thrombosis after thrombectomy (grade I to grade II lysis), additional thrombolysis was performed using urokinase. Seventy nine of 108 (73%) patients had residual venous stenoses post aspiration thrombectomy that were treated with stent placement and balloon angioplasty. There was no mortality associated with the procedure. On mid-term follow up, 61/75 patients (81.3%) had no recurrence of DVT and 14 patients (18.7%) demonstrated DVT recurrence. Fifty five patients (73.3%) were asymptomatic on mid-term follow-up and 20/75 (26.6%) had symptoms related to DVT. In the 52 patients who remained during long-term follow up, 41/52 (78.8%) had no recurrence of DVT and DVT recurrence was seen in 11/52 (21.1%). Thirty seven patients (71.1%) were asymptomatic on long-term follow-up and 15/52 (28.8%) were symptomatic. Conclusion: Aspiration thrombectomy is a safe, effective and economic treatment for acute proximal DVT. It showed similar clinical results with other treatment methods in mid and long term follow-up without any major complications.

ABSTRACT i TABLE OF CONTENTS iii LIST OF FIGURES iv LIST OF TABLES v ABBREVIATIONS vi Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 7 A. MATERIALS 7 1. Study population 7 B. METHODS 10 1. Procedure notes 11 2. Definitions and statistical analysis 16 3. Follow up 16 Ⅲ. RESULTS 17 Ⅳ. DISCUSSION 23 Ⅴ. CONCLUSION 30 REFERENCES 31 국문요약 36

Master

Advisors/Committee Members: 200924718, Anjali Basnyat Bista.

Subjects/Keywords: deep vein thrombosis; thrombectomy; thrombolysis; May Thurner syndrome; catheter

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APA (6^th Edition):

Bista, A. B. (2012). Aspiration Thrombectomy as the Sole Treatment for Acute and Sub-acute Deep Venous Thrombosis (DVT) of the Lower Extremity: mid and long-term clinical results. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/7579 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bista, Anjali Basnyat. “Aspiration Thrombectomy as the Sole Treatment for Acute and Sub-acute Deep Venous Thrombosis (DVT) of the Lower Extremity: mid and long-term clinical results.” 2012. Thesis, Ajou University. Accessed December 14, 2019. http://repository.ajou.ac.kr/handle/201003/7579 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bista, Anjali Basnyat. “Aspiration Thrombectomy as the Sole Treatment for Acute and Sub-acute Deep Venous Thrombosis (DVT) of the Lower Extremity: mid and long-term clinical results.” 2012. Web. 14 Dec 2019.

Vancouver:

Bista AB. Aspiration Thrombectomy as the Sole Treatment for Acute and Sub-acute Deep Venous Thrombosis (DVT) of the Lower Extremity: mid and long-term clinical results. [Internet] [Thesis]. Ajou University; 2012. [cited 2019 Dec 14]. Available from: http://repository.ajou.ac.kr/handle/201003/7579 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bista AB. Aspiration Thrombectomy as the Sole Treatment for Acute and Sub-acute Deep Venous Thrombosis (DVT) of the Lower Extremity: mid and long-term clinical results. [Thesis]. Ajou University; 2012. Available from: http://repository.ajou.ac.kr/handle/201003/7579 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000012199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Haut, Elliott R. Preventable Harm from Venous Thromboembolism (VTE) - A New Metric for Quality of Care.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/36954

► Venous thromboembolism (VTE), comprised of deep venous thrombosis (DVT) and pulmonary embolism (PE), is an underappreciated public health concern. According to the United States’ Surgeon’s… (more)

▼ Venous thromboembolism (VTE), comprised of deep venous thrombosis (DVT) and pulmonary embolism (PE), is an underappreciated public health concern. According to the United States’ Surgeon’s General “Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism,” VTE affects between 350,000-600,000 Americans each year, causing over 100,000 deaths annually. Even with overwhelming evidence of benefit, many hospitalized patients do not receive adequate VTE prophylaxis. The Agency for Healthcare Research and Quality (AHRQ) has called VTE prevention the number one strategy to improve patient safety in hospitals. As a consequence, many governmental agencies, accrediting bodies, and patient safety organizations have made improving VTE prophylaxis a priority and VTE is suggested as an ideal target for public reporting. However, VTE rates alone are not reliable as quality indicators. We suggest a more palatable and reliable measure of preventable harm from VTE. Chapter 1 shows how publicly reported VTE process and outcome measures fail to correlate and are not valid to benchmark hospitals. Chapter 2 explains how surveillance bias limits the role of VTE outcome reporting and offers a better solution- linking VTE process and outcome data into a single measure to define preventable harm. Chapter 3 summarizes published approaches to improve VTE prophylaxis for hospitalized patients. Chapter 4 offers perspectives on lessons learned while implementing a mandatory computerized clinical decision support tool to improve VTE prevention at our academic medical center. Chapters 5 and report data showing how our tool decreased preventable harm from VTE (using our definition) in adult trauma and medicine patients. Chapter 7 presents a real-world example of the feasibility of linking VTE prevention process and outcome measures. The work of this dissertation has already influenced national policy. By inclusion in The Centers for Medicare and Medicaid Services financial incentives programs for the “meaningful use” of certified electronic health record (EHR) technology to improve patient care. VTE-6 is defined as patients diagnosed with confirmed VTE who did not receive VTE prophylaxis" This definition followed our suggestion that “performance measures could link a process of care with adverse outcomes when defining incidences of preventable harm.” We posed the question; CMS now requires that all participating hospitals answer our query. Advisors/Committee Members: MacKenzie, Ellen J (advisor).

Subjects/Keywords: Quality; Venous Thromboembolism; Deep Vein Thrombosis; Pulmonary Embolism; Surveillance Bias

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APA (6^th Edition):

Haut, E. R. (2014). Preventable Harm from Venous Thromboembolism (VTE) - A New Metric for Quality of Care. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/36954

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haut, Elliott R. “Preventable Harm from Venous Thromboembolism (VTE) - A New Metric for Quality of Care.” 2014. Thesis, Johns Hopkins University. Accessed December 14, 2019. http://jhir.library.jhu.edu/handle/1774.2/36954.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haut, Elliott R. “Preventable Harm from Venous Thromboembolism (VTE) - A New Metric for Quality of Care.” 2014. Web. 14 Dec 2019.

Vancouver:

Haut ER. Preventable Harm from Venous Thromboembolism (VTE) - A New Metric for Quality of Care. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2019 Dec 14]. Available from: http://jhir.library.jhu.edu/handle/1774.2/36954.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haut ER. Preventable Harm from Venous Thromboembolism (VTE) - A New Metric for Quality of Care. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/36954

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

7. Palmer, Olivia. Non-Invasive Venous Thrombus Composition and Therapeutic Response by Multiparametric MRI.

Degree: PhD, Biomedical Engineering, 2019, University of Michigan

URL: http://hdl.handle.net/2027.42/149918

► Deep vein thrombosis (DVT), or a blood clot in a deep vein (commonly the legs), is known as the silent killer—there may be few or… (more)

▼ Deep vein thrombosis (DVT), or a blood clot in a deep vein (commonly the legs), is known as the silent killer—there may be few or no symptoms, yet a section of the thrombus could break free and travel to the lungs causing a potentially fatal pulmonary embolism. DVT and its complications affect 900,000 people in the U.S. each year, with one third of cases resulting in fatality. Anticoagulants (the standard treatment) pose serious bleeding risks and rely on the patient’s fibrinolytic system to break up the thrombus, which is often incapable of doing so thus leading to post thrombotic syndrome (PTS) in almost 50% of patients. Removing the DVT completely via thrombolytic treatments may improve quality of life by reducing PTS. However, thrombolysis is only effective on acute thrombi. Impaired success with thrombolytic treatment is due to heterogeneity in the thrombus (old clot, which is unable to be broken up, intermixed with fresh clot, which can easily be broken up). This problem is largely overlooked based on an inability to determine thrombus composition. Currently, the only method for determining disease stage is the patient’s recollection of when their symptoms began, which is inherently unreliable and could put the patient at risk. Further, thrombi of the same chronological age may organize at different rates in different people. Magnetic resonance imaging (MRI) has the potential to provide information about thrombus composition (clot age), and thus inform patient-specific treatment planning. Since there are several limitations to studying DVT in humans, animal models are key tools for understanding the disease. Mouse models are the most commonly used, providing a unique biological environment to study disease progression and treatment. Any model requires rigorous characterization and standardization to ensure reproducibility between studies. Our first objective was to quantify structural and functional changes in the healthy venous system of young and aged mice of both sexes, at rest and under conditions which simulate exercise. Second, we assessed the endogenous response to two models of DVT mimicking the two possible clinical scenarios: total or partial occlusion. Following the necessary model characterization, we developed a multiparametric MRI approach to probe thrombus composition without the need for contrast agents. Our results show imaging correlation with known composition by histology. This method provides a novel approach to study thrombus composition, and could eventually be used clinically to provide patient-specific treatment planning for DVT. Additionally, we investigated the impact of exercise, an emerging therapeutic option, on thrombus composition. Using an in-cage running wheel, our results show that spontaneous exercise – both alone and in combination with standard treatment – reduces initial thrombus size and contributes to thrombus resolution. We found that exercise increases acute fibrin content, attenuates local inflammation, and decreases sub-chronic collagen content in… Advisors/Committee Members: Diaz, Jose Antonio (committee member), Greve, Joan M (committee member), Chenevert, Thomas L (committee member), Fowlkes, Jeffrey Brian (committee member).

Subjects/Keywords: Deep Vein Thrombosis; MRI; Mouse Models; Biomedical Engineering; Engineering

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APA (6^th Edition):

Palmer, O. (2019). Non-Invasive Venous Thrombus Composition and Therapeutic Response by Multiparametric MRI. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/149918

Chicago Manual of Style (16^th Edition):

Palmer, Olivia. “Non-Invasive Venous Thrombus Composition and Therapeutic Response by Multiparametric MRI.” 2019. Doctoral Dissertation, University of Michigan. Accessed December 14, 2019. http://hdl.handle.net/2027.42/149918.

MLA Handbook (7^th Edition):

Palmer, Olivia. “Non-Invasive Venous Thrombus Composition and Therapeutic Response by Multiparametric MRI.” 2019. Web. 14 Dec 2019.

Vancouver:

Palmer O. Non-Invasive Venous Thrombus Composition and Therapeutic Response by Multiparametric MRI. [Internet] [Doctoral dissertation]. University of Michigan; 2019. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/2027.42/149918.

Council of Science Editors:

Palmer O. Non-Invasive Venous Thrombus Composition and Therapeutic Response by Multiparametric MRI. [Doctoral Dissertation]. University of Michigan; 2019. Available from: http://hdl.handle.net/2027.42/149918

8. Galanaud, Jean-Philippe. Les thromboses veineuses méconnues des membres inferieurs : thromboses veineuses profondes distales et thromboses veineuses superficielles : Epidemiology and early outcomes of superficial and distal deep veins thromboses of lower limbs.

Degree: Docteur es, Biologie Santé, 2011, Université Montpellier I

URL: http://www.theses.fr/2011MON1T027

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Rationnel: Bien qu'elles constituent la majorité des thromboses veineuses des membres inférieurs, les thromboses veineuses profondes (TVP) distale et les thromboses veineuses superficielles (TVS) ont… (more)

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Rationnel: Bien qu'elles constituent la majorité des thromboses veineuses des membres inférieurs, les thromboses veineuses profondes (TVP) distale et les thromboses veineuses superficielles (TVS) ont été peu étudiées et leur significativité clinique et leur prise en charge sont débattues.Méthodes: Cette thèse collige les résultats des travaux effectués par J.P. Galanaud sur les TVP distales et les TVS à partir des études épidémiologiques OPTIMEV, POST et RIETE.Résultats commentés: TVP distale: La TVP distale n'a pas le même profil de facteur de risque que la TVP proximale. Sa mortalité associée à court terme est plus faible que celle des TVP proximales mais supérieure à celle de témoins confirmant qu'il s'agit d'une entité cliniquement significative. Les différences de profil de population et de complications entre ces deux types de TVP suggèrent que le rapport bénéfice/risque du traitement anticoagulant est différent. Il n'est donc pas légitime d'extrapoler les résultats des essais des TVP proximales aux TVP distales. Des essais spécifiques sont donc nécessaires.TVS: En cas de TVS le risque de TVP concomitante est élevé. Un examen écho-doppler doit être réalisé et devra au moins explorer l'ensemble du réseau profond du membre inférieur affecté. Sexe masculin et antécédents de TVP/Embolie pulmonaire constituent des facteurs prédictifs indépendants de récidive. Si certaines TVS peuvent être traitées avec succès sans traitement anticoagulant, celles associées à un cancer ou à une atteinte saphéno-fémorale sont à haut risque de récidive y compris après un traitement anticoagulant curatif.

Background: Though they represent the majority of all lower limbs thromboses, isolated distal deep-vein thrombosis (DVT) (without symptomatic pulmonary embolism (PE)) and isolated superficial vein thrombosis (SVT) (without DVT or PE) have been poorly studied. Their clinical significance and management are under debate.Methods: Data from epidemiological multicenter prospective studies OPTIMEV, POST, RIETEResults and comments: Isolated distal DVT: Distal and proximal DVTs exhibit a different risk factor profile, the latter being more associated with chronic risk factors. Three-month mortality of distal DVT patient is lower than that of proximal DVT ones but is higher than that of controls. This evidences that distal DVT is a clinically significant finding. Differences in population profile and outcomes suggests that the benefit/risk ratio of anticoagulant treatment is not similar. Data from proximal DVT clinical trials should no longer be extrapolated to distal DVT.Isolated SVT: In case of SVT the risk of concomitant DVT is high. A compression ultrasonographic exam should be performed and at least explore the whole deep venous system of the affected limb. Male gender and history of DVT/Pulmonary embolism are independent predicators of recurrence. Some SVT can be safely treated without anticoagulants. On contrary, in patients with cancer or a sapheno-femoral junction involvement, the risk of deep venous recurrence is high even upon…

Advisors/Committee Members: Dauzat, Michel (thesis director), Leizorovicz, Alain (thesis director).

Subjects/Keywords: Thrombose veineuse profonde distale; Thrombose veineuse superficielle; Epidemiologie; Facteur de risque; Pronostic; Maladie veineuse thromboembolique; Distal deep vein thrombosis; Calf vein thrombosis; Risk factors; Superficial vein thrombosis; Prognosis; Epidemiology

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APA (6^th Edition):

Galanaud, J. (2011). Les thromboses veineuses méconnues des membres inferieurs : thromboses veineuses profondes distales et thromboses veineuses superficielles : Epidemiology and early outcomes of superficial and distal deep veins thromboses of lower limbs. (Doctoral Dissertation). Université Montpellier I. Retrieved from http://www.theses.fr/2011MON1T027

Chicago Manual of Style (16^th Edition):

Galanaud, Jean-Philippe. “Les thromboses veineuses méconnues des membres inferieurs : thromboses veineuses profondes distales et thromboses veineuses superficielles : Epidemiology and early outcomes of superficial and distal deep veins thromboses of lower limbs.” 2011. Doctoral Dissertation, Université Montpellier I. Accessed December 14, 2019. http://www.theses.fr/2011MON1T027.

MLA Handbook (7^th Edition):

Galanaud, Jean-Philippe. “Les thromboses veineuses méconnues des membres inferieurs : thromboses veineuses profondes distales et thromboses veineuses superficielles : Epidemiology and early outcomes of superficial and distal deep veins thromboses of lower limbs.” 2011. Web. 14 Dec 2019.

Vancouver:

Galanaud J. Les thromboses veineuses méconnues des membres inferieurs : thromboses veineuses profondes distales et thromboses veineuses superficielles : Epidemiology and early outcomes of superficial and distal deep veins thromboses of lower limbs. [Internet] [Doctoral dissertation]. Université Montpellier I; 2011. [cited 2019 Dec 14]. Available from: http://www.theses.fr/2011MON1T027.

Council of Science Editors:

Galanaud J. Les thromboses veineuses méconnues des membres inferieurs : thromboses veineuses profondes distales et thromboses veineuses superficielles : Epidemiology and early outcomes of superficial and distal deep veins thromboses of lower limbs. [Doctoral Dissertation]. Université Montpellier I; 2011. Available from: http://www.theses.fr/2011MON1T027

KTH

9. Daniel, Öberg. Clinical Assessment for Deep Vein Thrombosis using Support Vector Machines : A description of a clinical assessment and compression ultrasonography journaling system for deep vein thrombosis using support vector machines.

Degree: Computer Science and Communication (CSC), 2015, KTH

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-178419

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This master thesis describes a journaling system for compression ultrasonography and a clinical assessment system for deep vein thrombosis (DVT). We evaluate Support Vector… (more)

Subjects/Keywords: clinical assessment; compression ultrasonography; deep vein thrombosis; support vector machines; Computer Sciences; Datavetenskap (datalogi)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Daniel, �. (2015). Clinical Assessment for Deep Vein Thrombosis using Support Vector Machines : A description of a clinical assessment and compression ultrasonography journaling system for deep vein thrombosis using support vector machines. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-178419

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Daniel, Öberg. “Clinical Assessment for Deep Vein Thrombosis using Support Vector Machines : A description of a clinical assessment and compression ultrasonography journaling system for deep vein thrombosis using support vector machines.” 2015. Thesis, KTH. Accessed December 14, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-178419.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Daniel, Öberg. “Clinical Assessment for Deep Vein Thrombosis using Support Vector Machines : A description of a clinical assessment and compression ultrasonography journaling system for deep vein thrombosis using support vector machines.” 2015. Web. 14 Dec 2019.

Vancouver:

Daniel �. Clinical Assessment for Deep Vein Thrombosis using Support Vector Machines : A description of a clinical assessment and compression ultrasonography journaling system for deep vein thrombosis using support vector machines. [Internet] [Thesis]. KTH; 2015. [cited 2019 Dec 14]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-178419.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Daniel �. Clinical Assessment for Deep Vein Thrombosis using Support Vector Machines : A description of a clinical assessment and compression ultrasonography journaling system for deep vein thrombosis using support vector machines. [Thesis]. KTH; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-178419

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

10. Fox, Evan M. Fluid Dynamic Study of a Compliant Model for an Inferior Vena Cava Filter.

Degree: MS, Bioengineering, 2013, Penn State University

URL: https://etda.libraries.psu.edu/catalog/18070

► Deep vein thrombosis afflicts a reported 1 in 1000 persons, resulting in severe medical consequences for many as the thrombus may dislodge to form a… (more)

▼ Deep vein thrombosis afflicts a reported 1 in 1000 persons, resulting in severe medical consequences for many as the thrombus may dislodge to form a pulmonary embolism. If undiagnosed, this can cause impaired oxygenation, heart strain, or sudden death due to occlusion of blood flow in all cases. Multiple iterations of inferior vena cava (IVC) filters were developed to prevent such emboli from reaching the lungs. Yet, complications remain due to induced thrombus formation, intimal hyperplasia, perforation through the IVC, and filter fracture. The goal of this study was to examine flow phenomena around a Bard G2 Express IVC filter in an effort to identify areas likely to cause complications. A mock venous circulatory flow loop was constructed which features a compliant model for the vena cava. Clinically observed flow rates were matched for both resting (2.7 lpm) and exercise (5.5 lpm) conditions. The outlet pressure of the IVC was maintained at 11 mmHg. Particle image velocimetry (PIV) was used to measure the flow with high spatial resolution for the unoccluded, filtered, and occluded IVC. Multiple planes were taken to assess the three-dimensionality in the flow. Data concerning the flow impact following implantation of the filter and clot was recorded. Standard deviations were high for this study (median 28.8% of the velocity magnitude in the exercising midline right iliac). For the first time, three-dimensional characteristics were characterized in a PIV study concerning an IVC filter; both sets of conditions demonstrated asymmetric flow and jets altered direction between planes (especially in the resting, unoccluded case). Regions of recirculation were characteristic of all flows, especially under resting conditions. Wakes were present in both the filtered and occluded experiments, which could promote thrombus growth downstream of the filter or clot. Yet, the asymmetries may aid in the development of larger shear forces on the thrombus, facilitating thrombolysis.

Subjects/Keywords: deep vein thrombosis; pulmonary embolism; inferior vena cava filter; particle image velocimetry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fox, E. M. (2013). Fluid Dynamic Study of a Compliant Model for an Inferior Vena Cava Filter. (Masters Thesis). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/18070

Chicago Manual of Style (16^th Edition):

Fox, Evan M. “Fluid Dynamic Study of a Compliant Model for an Inferior Vena Cava Filter.” 2013. Masters Thesis, Penn State University. Accessed December 14, 2019. https://etda.libraries.psu.edu/catalog/18070.

MLA Handbook (7^th Edition):

Fox, Evan M. “Fluid Dynamic Study of a Compliant Model for an Inferior Vena Cava Filter.” 2013. Web. 14 Dec 2019.

Vancouver:

Fox EM. Fluid Dynamic Study of a Compliant Model for an Inferior Vena Cava Filter. [Internet] [Masters thesis]. Penn State University; 2013. [cited 2019 Dec 14]. Available from: https://etda.libraries.psu.edu/catalog/18070.

Council of Science Editors:

Fox EM. Fluid Dynamic Study of a Compliant Model for an Inferior Vena Cava Filter. [Masters Thesis]. Penn State University; 2013. Available from: https://etda.libraries.psu.edu/catalog/18070

11. Haruta, Shoji; Kawaguchi, Ryuji; Hirai, Toshiko. Sequential screening to predict symptomatic pulmonary thromboembolism after gynecologic surgery in Nara, Japan. : 婦人科手術術後の症候性肺血栓塞栓症予防スクリーニングの有用性についての検討.

Degree: 博士（医学）, 2016, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/3199

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OBJECTIVE: To evaluate a sequential screening method's efficacy in predicting symptomatic pulmonary thromboembolism (PTE) after gynecologic surgery. METHODS: A prospective study employing a two-stage screening… (more)

Subjects/Keywords: D-dimer; Deep vein thrombosis; Gynecologic surgery; Pulmonary thromboembolism; Sequential screening; Ultrasonography

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haruta, Shoji; Kawaguchi, Ryuji; Hirai, T. (2016). Sequential screening to predict symptomatic pulmonary thromboembolism after gynecologic surgery in Nara, Japan. : 婦人科手術術後の症候性肺血栓塞栓症予防スクリーニングの有用性についての検討. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/3199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haruta, Shoji; Kawaguchi, Ryuji; Hirai, Toshiko. “Sequential screening to predict symptomatic pulmonary thromboembolism after gynecologic surgery in Nara, Japan. : 婦人科手術術後の症候性肺血栓塞栓症予防スクリーニングの有用性についての検討.” 2016. Thesis, Nara Medical University / 奈良県立医科大学. Accessed December 14, 2019. http://hdl.handle.net/10564/3199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haruta, Shoji; Kawaguchi, Ryuji; Hirai, Toshiko. “Sequential screening to predict symptomatic pulmonary thromboembolism after gynecologic surgery in Nara, Japan. : 婦人科手術術後の症候性肺血栓塞栓症予防スクリーニングの有用性についての検討.” 2016. Web. 14 Dec 2019.

Vancouver:

Haruta, Shoji; Kawaguchi, Ryuji; Hirai T. Sequential screening to predict symptomatic pulmonary thromboembolism after gynecologic surgery in Nara, Japan. : 婦人科手術術後の症候性肺血栓塞栓症予防スクリーニングの有用性についての検討. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2016. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10564/3199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haruta, Shoji; Kawaguchi, Ryuji; Hirai T. Sequential screening to predict symptomatic pulmonary thromboembolism after gynecologic surgery in Nara, Japan. : 婦人科手術術後の症候性肺血栓塞栓症予防スクリーニングの有用性についての検討. [Thesis]. Nara Medical University / 奈良県立医科大学; 2016. Available from: http://hdl.handle.net/10564/3199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

12. Asplund, Jenny Domberg. Prevention mot djup ventrombos : vad säger evidensen och hur arbetar sjuksköterskan kliniskt?.

Degree: Public Health and Caring Sciences, 2016, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294573

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Bakgrund: Djup ventrombos (DVT) är en allvarlig komplikation efter kirurgiska och ortopediska ingrepp. Detta leder till ökat lidande för patienten, längre vårdtider och därav… (more)

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Bakgrund: Djup ventrombos (DVT) är en allvarlig komplikation efter kirurgiska och ortopediska ingrepp. Detta leder till ökat lidande för patienten, längre vårdtider och därav ökade kostnader för samhället. För att förebygga DVT krävs kunskap om vilka preventiva omvårdnadsåtgärder som har effekt och hur de ska användas. Syfte: Syftet med studien var att genom en systematisk litteraturstudie se vad kunskapsläget säger om preventiva omvårdnadsåtgärder mot DVT samt vad som ser mest effektivt ut. Syftet var också att genom en enkät ta reda på hur sjuksköterskor arbetar kliniskt för att förebygga DVT. Metod: Litteraturstudie som baserades på tio orginalartiklar. Som komplement till litteraturstudien gjordes även en enkätstudie som inkluderade tio sjuksköterskor. Resultat: Tidig mobilisering tillsammans med mekanisk profylax ses som effektivt för att förebygga DVT. I många av studierna som granskats gavs patienterna lågmolekylärt heparin (LMH). Det var dock ingen lägre frekvens av DVT hos dessa patienter jämfört med de som ej fick LMH. Det var vid införandet av profylaktiska omvårdnadsåtgärder som tidig mobilisering, kompressionsstrumpor och kompressionspumpar som frekvensen av DVT sjönk. Sjuksköterskorna arbetar aktivt med förebyggande omvårdnadsåtgärder men det finns dock inga specifika riktlinjer för dessa omvårdnadsåtgärder i den kliniska verksamheten. Slutsats: Studien visar att ett behov finns för utvecklandet av att arbeta med individanpassad profylax då patienterna utifrån olika riskgrupper har olika behov av profylaxtyper. Stor vikt bör läggas på att utveckla och implementera riktlinjer för tidig mobilisering då detta utifrån denna studies resultat har god effekt för att förebygga uppkomsten av DVT.

Background: Deep vein thrombosis is a serious complication during surgical and orthopaedic procedures. This leads to increased patient suffering, longer hospital stays and thereby also higher cost for society. To prevent DVT requires knowledge about preventive care measures that are effective, and how they will be used. Aim: The aim of this study was to examine the current state of knowledge about preventive care measures against DVT and how effective they are. The aim was also, by conducting a survey, to find out how nurses work clinically for the prevention of DVT. Study design: A literature study was conducted. The study was based on ten original articles. As a complement to the literature study a questionnaire was created and handed out to ten surgical and orthopaedic nurses. Results: Early mobilization in combination with mechanical prophylactics is seen as effective for preventing DVT. In many of the included studies patients were given low molecular weight heparin (LMH). However the frequency of DVT in these patients was not lower compared to those who did not get LMH. Instead it was at the introduction of prophylactic care measures such as early…

Subjects/Keywords: Deep vein thrombosis; komplikation; prophylaxis; surgery; orthopaedics; Djup ventrombos; komplikation; profylax; kirurgi; ortopedi

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Asplund, J. D. (2016). Prevention mot djup ventrombos : vad säger evidensen och hur arbetar sjuksköterskan kliniskt?. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Asplund, Jenny Domberg. “Prevention mot djup ventrombos : vad säger evidensen och hur arbetar sjuksköterskan kliniskt?.” 2016. Thesis, Uppsala University. Accessed December 14, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Asplund, Jenny Domberg. “Prevention mot djup ventrombos : vad säger evidensen och hur arbetar sjuksköterskan kliniskt?.” 2016. Web. 14 Dec 2019.

Vancouver:

Asplund JD. Prevention mot djup ventrombos : vad säger evidensen och hur arbetar sjuksköterskan kliniskt?. [Internet] [Thesis]. Uppsala University; 2016. [cited 2019 Dec 14]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Asplund JD. Prevention mot djup ventrombos : vad säger evidensen och hur arbetar sjuksköterskan kliniskt?. [Thesis]. Uppsala University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-294573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

13. Saldanha, Lisa J. A Mouse Model of Deep Vein Thrombosis Stability: The Effect of Direct Thrombin Inhibition.

Degree: MSc, 2012, McMaster University

URL: http://hdl.handle.net/11375/12582

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The effect of direction thrombin inhibition on acute deep vein thrombosis (DVT) stability has not been defined and could contribute to pulmonary embolism (PE)… (more)

Subjects/Keywords: Deep vein thrombosis; pulmonary embolism; thrombus stability; anticoagulants; intravital microscopy; Hematology; Hematology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saldanha, L. J. (2012). A Mouse Model of Deep Vein Thrombosis Stability: The Effect of Direct Thrombin Inhibition. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/12582

Chicago Manual of Style (16^th Edition):

Saldanha, Lisa J. “A Mouse Model of Deep Vein Thrombosis Stability: The Effect of Direct Thrombin Inhibition.” 2012. Masters Thesis, McMaster University. Accessed December 14, 2019. http://hdl.handle.net/11375/12582.

MLA Handbook (7^th Edition):

Saldanha, Lisa J. “A Mouse Model of Deep Vein Thrombosis Stability: The Effect of Direct Thrombin Inhibition.” 2012. Web. 14 Dec 2019.

Vancouver:

Saldanha LJ. A Mouse Model of Deep Vein Thrombosis Stability: The Effect of Direct Thrombin Inhibition. [Internet] [Masters thesis]. McMaster University; 2012. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/11375/12582.

Council of Science Editors:

Saldanha LJ. A Mouse Model of Deep Vein Thrombosis Stability: The Effect of Direct Thrombin Inhibition. [Masters Thesis]. McMaster University; 2012. Available from: http://hdl.handle.net/11375/12582

14. E. Tarantino. THE ROLE OF CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) IN A VENOUS THROMBOSIS MOUSE MODEL.

Degree: 2016, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/353697

► Background: Deep vein thrombosis (DVT) is a serious national health problem, and pulmonary thromboembolism (PE) represents the life-threatening most common complication. Venous thromboembolism (VTE), including… (more)

▼ Background: Deep vein thrombosis (DVT) is a serious national health problem, and pulmonary thromboembolism (PE) represents the life-threatening most common complication. Venous thromboembolism (VTE), including both these conditions, is traditionally treated with anticoagulant drugs. In particular, vitamin K antagonists and heparins are usually used in the reduction of thrombus development and in secondary prevention. However, the use of these drugs has several limitations: wide variability dose/response relationship between patients and in the same patient, multiple interactions with other drugs/foods, variability of daily doses, need of periodic withdrawals of blood during therapy, problems of overdosing. Then, the discovery of new drugs for VTE needs. The cyclooxygenase isoenzymes, COX-1 and COX-2, catalyse the formation of prostaglandins and, thromboxane from arachidonic acid, and play a critical role in thrombosis. Recent meta-analysis suggests that low-dose aspirin (ASA) reduces the rate of VTE recurrence. In contrast, the clinical use of COX-2 inhibitors seems associated with increased risk of venous thrombosis. However, the role of COX-1 and COX-2 in venous thrombosis remain unclear. Aim: We investigated the impact of COX-1 and COX-2 enzymes in venous thrombosis in order to identify the molecular mechanisms responsible for this effect and develop new therapeutic strategies to prevent venous thrombosis. In particular, we focused on the impact of inhibition of COX-pathway on leukocyte activation, important regulators of formation and propagation of venous thrombus. Methods and Results: Using in vivo and in vitro approaches, we provide evidence that: a) thromboxane, produced by platelets, triggers activation of leukocytes, with consequent development and propagation of venous thrombus induced by inferior vena cava ligation. In particular, we showed that ASA, by inhibiting irreversibly platelet COX-1, prevents platelet thromboxane production resulting in decreased venous thrombosis. b) COX-2 deletion induces platelet hyper-activity and hyper-coagulation state, associated with a reduced fibrinolysis and formation of bigger thrombi. In this scenario, the high levels of tissue factor observed in leukocytes of COX-2KO mouse may explain the positive association observed between administration of COX-2 inhibitors and VTE. Thanking advantage of an accurate, and clinically relevant, technique such as ultrasonography, we are setting a method helpful to monitor thrombus growing and to better understand the pathophysiology of venous thromboembolism. Conclusion: In conclusion, data obtained show that the inhibition of COX-1 and COX-2 in a venous thrombosis mouse model could lead to opposite effect on the thrombus development, stabilization and resolution. In particular, COX-1 inhibition is responsible of an impairment development and growth of venous thrombus, with a mechanism most likely dependent of TXA2/TP pathway. In contrast, COX-2 inhibition caused an increased in thrombus development, growing accompanied with… Advisors/Committee Members: tutor: E. Tremoli, co-tutor: S.S.Barbieri, coordinatore: A. Corsini, TREMOLI, ELENA, CORSINI, ALBERTO.

Subjects/Keywords: Deep Vein Thrmobosis (DVT); cyclooxygenase (COX); Aspirin; ThromboxaneA2 (TXA2); Settore BIO/14 - Farmacologia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tarantino, E. (2016). THE ROLE OF CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) IN A VENOUS THROMBOSIS MOUSE MODEL. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/353697

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tarantino, E.. “THE ROLE OF CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) IN A VENOUS THROMBOSIS MOUSE MODEL.” 2016. Thesis, Università degli Studi di Milano. Accessed December 14, 2019. http://hdl.handle.net/2434/353697.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tarantino, E.. “THE ROLE OF CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) IN A VENOUS THROMBOSIS MOUSE MODEL.” 2016. Web. 14 Dec 2019.

Vancouver:

Tarantino E. THE ROLE OF CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) IN A VENOUS THROMBOSIS MOUSE MODEL. [Internet] [Thesis]. Università degli Studi di Milano; 2016. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/2434/353697.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tarantino E. THE ROLE OF CYCLOOXYGENASE-1 (COX-1) AND CYCLOOXYGENASE-2 (COX-2) IN A VENOUS THROMBOSIS MOUSE MODEL. [Thesis]. Università degli Studi di Milano; 2016. Available from: http://hdl.handle.net/2434/353697

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

15. Bond, Alison Mary. Risk Stratification for Prevention of Venous Thromboembolism in Hospitalized Medical Patients: Can thromboprophylaxis be safely restricted to limit costs?.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/91375

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The objectives of this study were to estimate and compare the economic and clinical outcomes of using risk assessment models (RAMs) to support decision-making on… (more)

Subjects/Keywords: Cost; Deep Vein Thrombosis; Medical Patients; Pulmonary Embolism; Risk Assessment Models; Venous Thromboembolism; 0572

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bond, A. M. (2018). Risk Stratification for Prevention of Venous Thromboembolism in Hospitalized Medical Patients: Can thromboprophylaxis be safely restricted to limit costs?. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91375

Chicago Manual of Style (16^th Edition):

Bond, Alison Mary. “Risk Stratification for Prevention of Venous Thromboembolism in Hospitalized Medical Patients: Can thromboprophylaxis be safely restricted to limit costs?.” 2018. Masters Thesis, University of Toronto. Accessed December 14, 2019. http://hdl.handle.net/1807/91375.

MLA Handbook (7^th Edition):

Bond, Alison Mary. “Risk Stratification for Prevention of Venous Thromboembolism in Hospitalized Medical Patients: Can thromboprophylaxis be safely restricted to limit costs?.” 2018. Web. 14 Dec 2019.

Vancouver:

Bond AM. Risk Stratification for Prevention of Venous Thromboembolism in Hospitalized Medical Patients: Can thromboprophylaxis be safely restricted to limit costs?. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/1807/91375.

Council of Science Editors:

Bond AM. Risk Stratification for Prevention of Venous Thromboembolism in Hospitalized Medical Patients: Can thromboprophylaxis be safely restricted to limit costs?. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91375

16. Antoniou, Vasileios. Συσχετισμός της συμπαθητικής νεύρωσης και της εν τω βάθει θρομβοφλεβίτιδος σε χειρουργικές επεμβάσεις κοιλιάς.

Degree: 2017, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/40593

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In the present study fifteen body donors who died with pulmonary embolism and were used for training of second year medical students at the Athens… (more)

▼

In the present study fifteen body donors who died with pulmonary embolism and were used for training of second year medical students at the Athens Medical School. A total of 12 men and 3 women were studied over 5 years in the Anatomy workshop. In the study of the aforementioned preparations the presence of residual necrosis in the venous network was found. The vein tissue was studied by the immunofluorescence method, which is based on the specific binding of the labeled antibody to a fluorescent chromogen in its own antigen. For the study of the sympathetic system fluorescein was used as a fluorescent molecule, which allows targeting the fluorescent substance to specific proteins and cellular structures. The study is original in Greece and rare in the international field because it has been done in human material of veins, while internationally used for the respective animal experiment.

Μελετήθηκαν στην παρούσα έρευνα δεκαπέντε δωρητές σώματος, που απέθαναν με πνευμονική εμβολή και χρησιμοποιούνται για την εκπαίδευση των Βετών της Ιατρικής Σχολής Αθηνών. Συνολικά μελετήθηκαν 12 άνδρες και 3 γυναίκες σε διάστημα 5 ετών στο εργαστήριο της Ανατομίας. Κατά την μελέτη των προαναφερθέντων παρασκευασμάτων διαπιστώθηκε η παρουσία υπολειμματικής νέκρωσης στο φλεβικό δίκτυο. Ο ιστός των φλεβών μελετήθηκε με την μέθοδο του ανοσοφθορισμού, ο οποίος βασίζεται στην ειδική πρόσδεση του σεσημασμένου αντισώματος με φθορίζον χρωμογόνο στο δικό του αντιγόνο. Για την μελέτη του συμπαθητικού συστήματος χρησιμοποιήθηκε ως φθορίζον μόριο η φλουορεσκεΐνη, η οποία επιτρέπει να στοχεύουμε τη φθορίζουσα ουσία σε συγκεκριμένες πρωτεΐνες και κυτταρικές δομές. Η μελέτη είναι πρωτότυπη στην Ελλάδα και από τις σπάνιες στο διεθνή χώρο, διότι έγινε σε ανθρώπινο υλικό φλεβών, ενώ διεθνώς χρησιμοποιούνται για την αντίστοιχη μελέτη πειραματόζωα.

Subjects/Keywords: Εν τω βαθεί φλεβοθρόμφωση; Συμπαθητική νεύρωση; Deep vein thrombosis; Central sympathetic system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Antoniou, V. (2017). Συσχετισμός της συμπαθητικής νεύρωσης και της εν τω βάθει θρομβοφλεβίτιδος σε χειρουργικές επεμβάσεις κοιλιάς. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/40593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Antoniou, Vasileios. “Συσχετισμός της συμπαθητικής νεύρωσης και της εν τω βάθει θρομβοφλεβίτιδος σε χειρουργικές επεμβάσεις κοιλιάς.” 2017. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed December 14, 2019. http://hdl.handle.net/10442/hedi/40593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Antoniou, Vasileios. “Συσχετισμός της συμπαθητικής νεύρωσης και της εν τω βάθει θρομβοφλεβίτιδος σε χειρουργικές επεμβάσεις κοιλιάς.” 2017. Web. 14 Dec 2019.

Vancouver:

Antoniou V. Συσχετισμός της συμπαθητικής νεύρωσης και της εν τω βάθει θρομβοφλεβίτιδος σε χειρουργικές επεμβάσεις κοιλιάς. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10442/hedi/40593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Antoniou V. Συσχετισμός της συμπαθητικής νεύρωσης και της εν τω βάθει θρομβοφλεβίτιδος σε χειρουργικές επεμβάσεις κοιλιάς. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. Available from: http://hdl.handle.net/10442/hedi/40593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pennsylvania

17. Martinez, Marissa Rose. The Role of Fibrin Clot Properties and Fibrinogen Nitration in the Pathology of Venous Thromboembolism.

Degree: 2012, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/670

► Deep vein thrombosis (DVT) and pulmonary embolism (PE) together comprise the disease state of venous thromboembolism (VTE). Thrombi in the veins of the lower extremities… (more)

▼ Deep vein thrombosis (DVT) and pulmonary embolism (PE) together comprise the disease state of venous thromboembolism (VTE). Thrombi in the veins of the lower extremities (DVT) can embolize, resulting in complete or partial occlusion of circulation through the pulmonary vasculature (PE). Despite a common etiology between DVT and PE, the cause of embolization remains mostly unknown. Research indicates that fibrin clot structure and functional properties are altered in VTE compared to healthy controls. Whether these properties differ between DVT and PE subjects remains to be determined, and may underscore possible mechanisms of embolization. Inflammation and oxidant production are involved in the pathogenesis of VTE. However, biomarkers documenting these pathways in humans are lacking. Elevated levels of nitrated fibrinogen have been documented during inflammatory and oxidative challenges and may serve as a functional biomarker in VTE. Differences in fibrin clot structure and functional properties between DVT and PE, as well as the role of nitrated fibrinogen as a biomarker of VTE were evaluated in the plasma of subjects presenting with symptoms of VTE to the emergency department at the Hospital of the University of Pennsylvania. Plasma fibrin clots derived from PE subjects showed increased establishment of viscoelastic properties and faster lysis time compared with DVT. The rate and extent of factor XIIIa crosslinking of fibrin were similar between DVT and PE. Clots from PE subjects showed decreased fiber density and no differences in fiber bundling. Together these data suggests that fibrin fibers are formed faster in PE subjects, possibly resulting in earlier lysis, which may lead to instability and embolization. Nitrated fibrinogen levels were elevated in VTE positive compared to VTE negative subjects, with no differences in fibrinogen concentration. Subjects in the highest quartile of nitrated fibrinogen had an increased risk of VTE compared with the lowest quartile. This risk persisted after univariate adjustment for advanced age, active cancer, and recent surgery, but not after multivariate adjustment for all variables. Thus, nitrated fibrinogen is an oxidative risk marker in VTE, providing a novel mechanistic link between oxidant production, inflammation, and VTE.

Subjects/Keywords: Deep vein thrombosis; Fibrinogen; Nitration; Pulmonary embolism; Venous thromboembolism; Biochemistry; Molecular Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martinez, M. R. (2012). The Role of Fibrin Clot Properties and Fibrinogen Nitration in the Pathology of Venous Thromboembolism. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/670

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martinez, Marissa Rose. “The Role of Fibrin Clot Properties and Fibrinogen Nitration in the Pathology of Venous Thromboembolism.” 2012. Thesis, University of Pennsylvania. Accessed December 14, 2019. https://repository.upenn.edu/edissertations/670.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martinez, Marissa Rose. “The Role of Fibrin Clot Properties and Fibrinogen Nitration in the Pathology of Venous Thromboembolism.” 2012. Web. 14 Dec 2019.

Vancouver:

Martinez MR. The Role of Fibrin Clot Properties and Fibrinogen Nitration in the Pathology of Venous Thromboembolism. [Internet] [Thesis]. University of Pennsylvania; 2012. [cited 2019 Dec 14]. Available from: https://repository.upenn.edu/edissertations/670.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martinez MR. The Role of Fibrin Clot Properties and Fibrinogen Nitration in the Pathology of Venous Thromboembolism. [Thesis]. University of Pennsylvania; 2012. Available from: https://repository.upenn.edu/edissertations/670

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

18. Zhang, Xi. Noninvasive Thrombolysis using Microtripsy.

Degree: PhD, Biomedical Engineering, 2016, University of Michigan

URL: http://hdl.handle.net/2027.42/135813

► Thrombosis refers to blood clot formation and when pathological, is the cause of many vascular diseases. For example, deep vein thrombosis (DVT), which affects three… (more)

▼ Thrombosis refers to blood clot formation and when pathological, is the cause of many vascular diseases. For example, deep vein thrombosis (DVT), which affects three million Americans per year, is the formation of clots in the deep veins of the legs. Current clinical treatments include thrombolytic drugs and catheter-based surgical procedures. Both methods have significant drawbacks, such as excessive bleeding, invasiveness, and long treatment time. Ultrasound has been combined with thrombolytic drugs and/or microbubbles to enhance drug delivery. However, these methods are still quite slow and share the drawbacks of thrombolytic drugs. Histotripsy is a tissue ablation method that mechanically fractionates soft tissue via well-controlled acoustic cavitation generated by microsecond-long, high-pressure ultrasound pulses. The initial feasibility and safety of using histotripsy as a noninvasive, drug-free, and image-guided thrombolysis technique has been demonstrated both in vitro and in vivo. The overriding goal of this dissertation is clinical translation of histotripsy thrombolysis. First, an integrated image-guided histotripsy thrombolysis system suitable for clinical DVT treatment are designed and constructed. Second, the recently discovered technical innovations, microtripsy and bubble-induced color Doppler (BCD), are investigated for histotripsy thrombolysis application to further improve treatment efficacy. Microtripsy is a new histotripsy approach and uses an intrinsic threshold mechanism to generate more reproducible and predictable cavitation via a single ultrasound pulse, which can minimize vessel damage by confining cavitation within vessel lumen and eliminate cavitation on vessel wall. BCD is developed to monitor tissue motion induced by histotripsy pulses and investigated as a real-time quantitative feedback for histotripsy thrombolysis. Finally, a comprehensive pre-clinical study in a large animal DVT model is conducted to validate the safety and efficacy of this clinically designed system incorporating these technical innovations. It is our hope that this dissertation work will establish a foundation for the translation of this noninvasive thrombolysis technology into relevant clinical applications. Advisors/Committee Members: Xu, Zhen (committee member), Fowlkes, Jeffrey Brian (committee member), Cain, Charles A (committee member), Gurm, Hitinder Singh (committee member), Owens, Gabe E (committee member).

Subjects/Keywords: sonothrombolysis; histotripsy; deep vein thrombosis; microtripsy; bubble-induced color Doppler; noninvasive thrombolysis; Biomedical Engineering; Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, X. (2016). Noninvasive Thrombolysis using Microtripsy. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/135813

Chicago Manual of Style (16^th Edition):

Zhang, Xi. “Noninvasive Thrombolysis using Microtripsy.” 2016. Doctoral Dissertation, University of Michigan. Accessed December 14, 2019. http://hdl.handle.net/2027.42/135813.

MLA Handbook (7^th Edition):

Zhang, Xi. “Noninvasive Thrombolysis using Microtripsy.” 2016. Web. 14 Dec 2019.

Vancouver:

Zhang X. Noninvasive Thrombolysis using Microtripsy. [Internet] [Doctoral dissertation]. University of Michigan; 2016. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/2027.42/135813.

Council of Science Editors:

Zhang X. Noninvasive Thrombolysis using Microtripsy. [Doctoral Dissertation]. University of Michigan; 2016. Available from: http://hdl.handle.net/2027.42/135813

Washington University in St. Louis

19. Lee, Sanghun Alex. The Effect of Mechanical Agitator Geometry on Catheter Directed Thrombectomy.

Degree: MS, Mechanical Engineering & Materials Science, 2019, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/463

► Venous thromboembolism (VTE) is a vascular disease in which a blood clot forms inside of a vein, most often deep in the legs, groin,… (more)

▼ Venous thromboembolism (VTE) is a vascular disease in which a blood clot forms inside of a vein, most often deep in the legs, groin, or arm. Two types of VTE exist, deep vein thrombosis (DVT) and pulmonary embolism (PE). DVT occurs when a clot in a deep vein forms, risking embolism and causing swelling as the clot obstructs blood ﬂow. An embolism occurs when a part or all the thrombus breaks off and travels in the circulation, getting lodged in the lungs. A pulmonary embolism is a very serious medical condition and can be fatal if not treated immediately. Current guidelines for treatment recommend oral administration of blood thinners, but in cases where alternative measures are needed, intervention with catheter directed thrombolysis (CDT) is commonly attempted. Methods for catheter directed thrombolysis vary greatly, but a regular feature is the option for mechanical agitation. The most commonly seen mechanic for mechanical agitation involves an expanding mesh geometry that is expanded either behind or within the thrombus. The issue with mesh geometries lies in the delicate cell lining of the vessel. Any injury to the vessel lining can cause the recurrence of a VTE as a post treatment complication. Mesh geometries risk breakage, and the expanding radial size can risk contact with the vessel lining. To overcome this disadvantage, we present a novel design for mechanical agitation in catheter directed thrombolysis. In this novel method, a rail mounted ﬁn geometry that is constrained to the centerline is advanced and retracted through a sample thrombus to break up the thrombus and restore ﬂow through the vessel. To this end to study this geometry performance, three performance objectives were outlined. The objectives were peak penetration force, average forward movement force, and average mass of sample removed. 3D printed geometries varying in two angles were tested on porcine thrombus samples for the three objectives. Results suggest that the angle of pitch relative to the front face of the geometry, is very impactful on penetration and forward movement. Advisors/Committee Members: Guy Genin, Mohamed Zayed, Guy Genin Mohamed Zayed Jessica Wagenseil.

Subjects/Keywords: Deep Vein Thrombosis; Catheter Directed Thrombolysis; Mechanical Agitator; Engineering; Surgical Procedures, Operative

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, S. A. (2019). The Effect of Mechanical Agitator Geometry on Catheter Directed Thrombectomy. (Thesis). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Sanghun Alex. “The Effect of Mechanical Agitator Geometry on Catheter Directed Thrombectomy.” 2019. Thesis, Washington University in St. Louis. Accessed December 14, 2019. https://openscholarship.wustl.edu/eng_etds/463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Sanghun Alex. “The Effect of Mechanical Agitator Geometry on Catheter Directed Thrombectomy.” 2019. Web. 14 Dec 2019.

Vancouver:

Lee SA. The Effect of Mechanical Agitator Geometry on Catheter Directed Thrombectomy. [Internet] [Thesis]. Washington University in St. Louis; 2019. [cited 2019 Dec 14]. Available from: https://openscholarship.wustl.edu/eng_etds/463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee SA. The Effect of Mechanical Agitator Geometry on Catheter Directed Thrombectomy. [Thesis]. Washington University in St. Louis; 2019. Available from: https://openscholarship.wustl.edu/eng_etds/463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Lucía Cuesta, José Félix. Factores predictivos de retrombosis: clínica y trombofilia.

Degree: 2016, Universidad de Zaragoza, Prensas de la Universidad

URL: http://zaguan.unizar.es/record/47874

► 1) Introducción: la enfermedad tromboembólica venosa (ETEV) es una enfermedad de etiología multifactorial que continúa generando una morbi-mortalidad importante a pesar de los avances en… (more)

▼ 1) Introducción: la enfermedad tromboembólica venosa (ETEV) es una enfermedad de etiología multifactorial que continúa generando una morbi-mortalidad importante a pesar de los avances en su etiopatogenia desarrollados en las últimas décadas. Son numerosos los factores de riesgo descritos en la génesis del tromboembolismo venoso (TEV), tanto genéticos como adquiridos. 2) Hipótesis y objetivos: en un intento de dilucidar la importancia de los distintos factores trombofílicos, decidimos realizar un estudio en una cohorte de pacientes con un episodio de TEV previo para determinar la relación de los distintos factores trombofílicos genéticos y/o adquiridos y el riesgo de retrombosis, otros objetivos principales fueron evaluar la correlación de los niveles elevados de FVIII: C y el riesgo de recurrencia trombótica, así como la presencia de factores de riesgo clínicos y el riesgo de nuevo TEV. 3) Material y métodos: 242 pacientes fueron remitidos a Consulta externa de Hematología del Hospital Santa Bárbara de Soria para estudio de trombofilia. 199 pacientes diagnosticados de TEV de enero de 1998 a diciembre de 2010 fueron evaluables. Se procedió a la realización de estudio de trombofilia con la determinación de: Antitrombina (AT), Proteína C (PC) y Proteína S (PS) coagulantes, PS libre, dímero D (DD), factor VIII coagulante (FVIII:C), resistencia a la PC activada (r-PCA), anticuerpos antifosfolípido (anticoagulante lúpico (AL), anticuerpos anticardiolipina (aCL) Ig G e IG M y anti-b2-glicoproteina IgG (anti-b2-GPI IgG)) y detección de mutaciones del factor V Leiden (FVL), G20210A protrombina (MGP) y C677T de la metilen-tetrahidrofolato-reductasa (MTHFR) y a la revisión de la exposición de distintos factores de riesgo trombótico adquiridos como: la edad, presencia de TEV espontáneo al diagnóstico, cirugía previa, inmovilización o traumatismo, embarazo/puerperio, tratamiento hormonal previo al primer episodio, etc. 4) Resultados: 199 pacientes con una mediana de edad al primer episodio de 42 años. 56,8% hombres y 43,2% mujeres. Los pacientes con déficit de PS libre y anticoagulante lúpico positivos tuvieron mayor incidencia de retrombosis (p= 0,011 y p= 0,012 respetivamente). Los niveles elevados de FVIII:C se asociaron a mayor riesgo de retrombosis de forma estadísticamente significativa (p=0,011). Respecto a las variables clínicas, la edad mayor a 55 años y la presencia de TEV espontáneo al diagnóstico se relacionaron con mayor riesgo de recidiva trombótica (p= 0,001 y p= 0,038 respectivamente). Al realizar el análisis multivariante (regresión de Cox), las siguientes variables mostraron ser factor de riesgo independiente para el desarrollo de retrombosis: el déficit de PS libre ( HR: 2,52; p= 0,019), los niveles elevados de FVIII:C (HR: 2,27; p=0,021) y la edad > a 55 años ( HR: 2,30; p=0,012).

Subjects/Keywords: hematología; trombosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lucía Cuesta, J. F. (2016). Factores predictivos de retrombosis: clínica y trombofilia. (Thesis). Universidad de Zaragoza, Prensas de la Universidad. Retrieved from http://zaguan.unizar.es/record/47874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lucía Cuesta, José Félix. “Factores predictivos de retrombosis: clínica y trombofilia.” 2016. Thesis, Universidad de Zaragoza, Prensas de la Universidad. Accessed December 14, 2019. http://zaguan.unizar.es/record/47874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lucía Cuesta, José Félix. “Factores predictivos de retrombosis: clínica y trombofilia.” 2016. Web. 14 Dec 2019.

Vancouver:

Lucía Cuesta JF. Factores predictivos de retrombosis: clínica y trombofilia. [Internet] [Thesis]. Universidad de Zaragoza, Prensas de la Universidad; 2016. [cited 2019 Dec 14]. Available from: http://zaguan.unizar.es/record/47874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lucía Cuesta JF. Factores predictivos de retrombosis: clínica y trombofilia. [Thesis]. Universidad de Zaragoza, Prensas de la Universidad; 2016. Available from: http://zaguan.unizar.es/record/47874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Frappé, Paul. Epidémiologie en soins primaires de la thrombose veineuse superficielle des membres inférieurs : Epidemiology of superficial-vein thrombosis of the legs in primary care.

Degree: Docteur es, Biologie, Médecine, Santé, 2015, Saint-Etienne

URL: http://www.theses.fr/2015STET004T

►

La sévérité potentielle de la thrombose veineuse superficielle (TVS) des membres inférieurs a récemment été documentée par des études réalisées en soins secondaires et tertiaires.… (more)

▼

La sévérité potentielle de la thrombose veineuse superficielle (TVS) des membres inférieurs a récemment été documentée par des études réalisées en soins secondaires et tertiaires. Son épidémiologie reste cependant inconnue en soins primaires. Le premier objectif de ce travail était de mesurer la prévalence de la TVS en soins primaires, ainsi que le taux d'évènements thromboemboliques concomitants au moment du diagnostic. Pour y répondre, un réseau de recherche collaborative entre médecins généralistes et médecins vasculaires de la région stéphanoise a été mis en place. Une étude transversale descriptive a été réalisée au sein de ce réseau pendant un an. La prévalence annuelle de la TVS a été mesurée à 0,64 pour mille habitants. Au moment du diagnostic, 24,6% des TVS étaient associées à une thrombose veineuse profonde symptomatique et 4,7% à une embolie pulmonaire symptomatique. Une seconde étude a recherché une variation saisonnière de la fréquence de la TVS en analysant les données individuelles de trois études aux designs différents ; l'étude STENOX, l'étude POST et l'étude STEPH. Une variation significative n'a été retrouvée que dans l'étude POST, et les peak-to-low ratios étaient inférieurs à 1,2 dans les trois études. Ainsi, si une variation existe, celle-ci parait être de faible envergure, sans conséquence sur la pratique et la recherche

The potential severity of superficial vein thrombosis (SVT) of the lower limbs has recently been shown by studies perfomed in secondary and tertiary care. The epidemiology of SVT remains unknown in primary care. The first objective of this study was to measure the prevalence of SVT in primary care, and the rate of concomitant thromboembolic events at diagnosis. A collaborative research network between general practitioners and vascular physicians from Saint-Etienne has been set up. A cross-sectional study has been conducted within this network during one year. The annual prevalence of SVT was measured to 0.64 per thousand inhabitants. At diagnosis, 24.6% of SVT were associated with symptomatic deep vein thrombosis and 4.7% with symptomatic pulmonary embolism. A second study was looking for a seasonal variation of SVT frequency by analyzing individual data from three studies with different designs; the STENOX study, the POST study and the STEPH study. A significant variation was found only in the POST study, and peak-to-low ratios were below 1.2 in the three studies. Thus, if other more powerful and exhaustive studies could find a seasonal variation, that variation would probably be of low magnitude and without clinical significance

Advisors/Committee Members: Tardy, Bernard (thesis director).

Subjects/Keywords: Thrombose veineuse superficielle; Membres inférieurs; Traitement anticoagulant; Fondaparinux; Thrombose veineuse profonde; Embolie pulmonaire; Variation saisonnière; Superficial vein thrombosis; Legs; Anticoagulating treatment; Fondaparinux; Deep vein thrombosis; Pulmonary embolism; Seasonal variation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Frappé, P. (2015). Epidémiologie en soins primaires de la thrombose veineuse superficielle des membres inférieurs : Epidemiology of superficial-vein thrombosis of the legs in primary care. (Doctoral Dissertation). Saint-Etienne. Retrieved from http://www.theses.fr/2015STET004T

Chicago Manual of Style (16^th Edition):

Frappé, Paul. “Epidémiologie en soins primaires de la thrombose veineuse superficielle des membres inférieurs : Epidemiology of superficial-vein thrombosis of the legs in primary care.” 2015. Doctoral Dissertation, Saint-Etienne. Accessed December 14, 2019. http://www.theses.fr/2015STET004T.

MLA Handbook (7^th Edition):

Frappé, Paul. “Epidémiologie en soins primaires de la thrombose veineuse superficielle des membres inférieurs : Epidemiology of superficial-vein thrombosis of the legs in primary care.” 2015. Web. 14 Dec 2019.

Vancouver:

Frappé P. Epidémiologie en soins primaires de la thrombose veineuse superficielle des membres inférieurs : Epidemiology of superficial-vein thrombosis of the legs in primary care. [Internet] [Doctoral dissertation]. Saint-Etienne; 2015. [cited 2019 Dec 14]. Available from: http://www.theses.fr/2015STET004T.

Council of Science Editors:

Frappé P. Epidémiologie en soins primaires de la thrombose veineuse superficielle des membres inférieurs : Epidemiology of superficial-vein thrombosis of the legs in primary care. [Doctoral Dissertation]. Saint-Etienne; 2015. Available from: http://www.theses.fr/2015STET004T

22. Fiore, Valerio. Metalli pesanti ed elementi in traccia nel particolato atmosferico inferiore a 10 micron nei capelli di soggetti con diagnosi di tromboembolismo venoso e di soggetti sani e relazione con lo stress ossidativo.

Degree: 2017, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/3867

► Il tromboembolismo venoso (TEV), che comprende la trombosi venosa profonda (DVT) e l embolia polmonare (PE), è la terza patologia più frequente tra le malattie… (more)

▼ Il tromboembolismo venoso (TEV), che comprende la trombosi venosa profonda (DVT) e l embolia polmonare (PE), è la terza patologia più frequente tra le malattie cardiovascolari dopo la cardiopatia ischemica e l ictus. L inquinamento atmosferico aumenta significativamente la morbidità e la mortalità cardiovascolare nella popolazione generale. Obiettivi: valutare le concentrazioni dei metalli pesanti nei capelli, come indice di accumulo corporeo e correlarle con i valori riscontrati nel microparticolato (PM10) in soggetti con trombosi venosa profonda degli arti inferiori (DVT) e in soggetti che non presentano tale patologia per studiare se tali metalli tossici, o una carenza di metalli essenziali possano avere un ruolo nel DVT. Valutare alcuni indicatori surrogati dello stress ossidativo, nei pazienti con DVT e nei soggetti sani di controllo per evidenziare eventuali squilibri nel bilancio ossidoriduttivo. Valutare le concentrazioni dei metalli pesanti presenti nel PM10 nelle aree urbane ed extraurbane della città di Catania e studiarne eventuali differenze, in modo da poter considerare se, e quanto, l inquinamento atmosferico attraverso l accumulo di metalli nell organismo possa avere rilevanza nel fenomeno DVT. Materiali e metodi: lo studio si è basato su 24 casi e 46 controlli, maschi e femmine di età compresa tra i 43 e i 71 anni, provenienti dalla città e dalla provincia di Catania. Tutti i soggetti sono stati sottoposti: al test di compressione ultrasonografica degli arti inferiori per l individuazione della trombosi; valutazione in campione di capelli dei metalli pesanti per ottenere un indice di accumulo corporeo; valutazione nel microparticolato delle aree di residenza e lavoro come indice di esposizione all inquinamento; prelievo ematico per la valutazione di indicatori dello stress ossidativo. Risultati: il confronto dei metalli nei capelli e nel microparticolato tra i gruppi appartenenti alle aree urbane ed extraurbane mostra una uguale esposizione, verosimilmente attribuibile al pendolarismo per motivi di lavoro e istruzione ed alla brezza marina pomeridiana che disperde l inquinamento atmosferico nella zona urbana. Dal confronto dei metalli corporei è emerso come nei soggetti con DVT, sia evidente una carenza di metalli essenziali utili per lo svolgimento delle normali funzioni biologiche, tra cui quelle di difesa antiossidante. Nei soggetti con DVT inoltre si è evidenziato un livello significativamente più elevato di Pb nell organismo (p = 0.04), il quale costituisce un noto agente tossico e gioca un ruolo nella patogenesi del tromboembolismo. Nei soggetti con DVT c è una tendenza (non significativa, p=0.11) ad uno stato di carenza del sistema di difesa ossidoriduttiva evidenziato da valori di Superossidodismutasi (SOD) più bassi rispetto ai controlli. Inoltre gli indicatori di stress ossidativo sono più elevati nei casi rispetto ai controlli, raggiungendo la significatività statistica nel caso di Malonildialdeide (p<0.001) e TBARS (p<0.001). Anche i valori di 4-idrossinonenal risultano più…

Subjects/Keywords: Area 06 - Scienze mediche; pollution,heavy,metals,deep,vein,thrombosis,oxidative,stress,particulate,matter,hair,Catania

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fiore, V. (2017). Metalli pesanti ed elementi in traccia nel particolato atmosferico inferiore a 10 micron nei capelli di soggetti con diagnosi di tromboembolismo venoso e di soggetti sani e relazione con lo stress ossidativo. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/3867

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fiore, Valerio. “Metalli pesanti ed elementi in traccia nel particolato atmosferico inferiore a 10 micron nei capelli di soggetti con diagnosi di tromboembolismo venoso e di soggetti sani e relazione con lo stress ossidativo.” 2017. Thesis, Università degli Studi di Catania. Accessed December 14, 2019. http://hdl.handle.net/10761/3867.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fiore, Valerio. “Metalli pesanti ed elementi in traccia nel particolato atmosferico inferiore a 10 micron nei capelli di soggetti con diagnosi di tromboembolismo venoso e di soggetti sani e relazione con lo stress ossidativo.” 2017. Web. 14 Dec 2019.

Vancouver:

Fiore V. Metalli pesanti ed elementi in traccia nel particolato atmosferico inferiore a 10 micron nei capelli di soggetti con diagnosi di tromboembolismo venoso e di soggetti sani e relazione con lo stress ossidativo. [Internet] [Thesis]. Università degli Studi di Catania; 2017. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10761/3867.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fiore V. Metalli pesanti ed elementi in traccia nel particolato atmosferico inferiore a 10 micron nei capelli di soggetti con diagnosi di tromboembolismo venoso e di soggetti sani e relazione con lo stress ossidativo. [Thesis]. Università degli Studi di Catania; 2017. Available from: http://hdl.handle.net/10761/3867

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Australia

23. Edwards, Janice. Factors influencing the development of severe venous changes following deep vein thrombosis.

Degree: PhD, 2010, University of Western Australia

URL: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=30462&local_base=GEN01-INS01

►

Salinity is an increasing stress with adverse effects on farming systems, and especially those in arid and semi-arid regions of the world, and in Australia.… (more)

▼

Salinity is an increasing stress with adverse effects on farming systems, and especially those in arid and semi-arid regions of the world, and in Australia. Chickpea is a salt sensitive cool-season legume crop that has been grown in semi-arid regions as a major source of protein for humans. Salt tolerance in chickpea has received relatively little attention, as previous studies indicated low levels of salt tolerance in chickpea. A recent large scale screening at ICRISAT, however, revealed 5 fold variation in yield under salinity. Information on the physiological basis of ion regulation in plant tissues was contradictory, and no information was available on the inheritance of key agronomic and physiological traits and identification of genomic regions for salt tolerance in chickpea. Thus, this thesis had the following objectives; 1a) study the sensitivity/tolerance of vegetative and reproductive growth stages with an altered treatment at flower initiation stage, 1b) assess ion toxicity in different tissues like shoot, root and floral structures; 2) study the type of gene action involved in controlling different traits under salinity using ‗Generation mean analysis‘ from six populations (P1,P2, F1, F2, BC1P1 and BC1P2). Parents were selected based on seed yield in two years of screening using 80 mM NaCl in pots of soil; 3) Development of F8 RILs (ICC6263 x ICC1431) and, construct a linkage map to identify the quantitative trait loci (QTL) for various agronomic traits under saline conditions. Results showed that both vegetative and reproductive phases were sensitive to salt and high ion concentrations (Na+ and Cl-) were observed in floral structures along with shoot and root.

Pollen viability was not affected in plants grown in saline treatment, but in vitro germination of pollen was reduced significantly even at 40 mM NaCl in the germination medium. Gene action studies indicated that yield traits were under the control of additive gene effects only and with high influence of the sensitive parent. Moreover, in the segregating population and F8 RILs it was confirmed that formation of empty pods was not the cause of reduction in yield, however decreases in pod and therefore seed numbers were found to be the major trait that contributed to yield reduction under salinity. Heritability parameters were influenced by large environmental factors which led to over estimation of the values. QTL mapping studies identified more than 20 regions (for seed yield, seed size and shoot biomass) on the chickpea linkage map spanning a length of 241 cM with 75 SSR markers. As anticipated, because of the quantitative nature of salt tolerance the magnitudes of phenotypic variance explained by each QTL were about 8-9%, and such occurrence of low phenotypic variation is consistent with results also from other crop species under saline conditions, as salinity tolerance is a complex multi-gene trait. In conclusion, ion toxicity, especially in reproductive structures was found to be critical in understanding the sensitivity of chickpea for…

Subjects/Keywords: Pulmonary embolism; Thrombophlebitis; Veins; Disease susceptibility; Genetic polymorphisms; Thromboembolism; Deep vein thrombosis; Genetic polymorphisms; Post-thrombotic syndrome; Vebous ulceration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Edwards, J. (2010). Factors influencing the development of severe venous changes following deep vein thrombosis. (Doctoral Dissertation). University of Western Australia. Retrieved from http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=30462&local_base=GEN01-INS01

Chicago Manual of Style (16^th Edition):

Edwards, Janice. “Factors influencing the development of severe venous changes following deep vein thrombosis.” 2010. Doctoral Dissertation, University of Western Australia. Accessed December 14, 2019. http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=30462&local_base=GEN01-INS01.

MLA Handbook (7^th Edition):

Edwards, Janice. “Factors influencing the development of severe venous changes following deep vein thrombosis.” 2010. Web. 14 Dec 2019.

Vancouver:

Edwards J. Factors influencing the development of severe venous changes following deep vein thrombosis. [Internet] [Doctoral dissertation]. University of Western Australia; 2010. [cited 2019 Dec 14]. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=30462&local_base=GEN01-INS01.

Council of Science Editors:

Edwards J. Factors influencing the development of severe venous changes following deep vein thrombosis. [Doctoral Dissertation]. University of Western Australia; 2010. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=30462&local_base=GEN01-INS01

Cape Peninsula University of Technology

24. Brock, Sheila Anne. Compression and Doppler ultrasound of deep vein thrombosis in patients on tuberculosis treatment .

Degree: 2013, Cape Peninsula University of Technology

URL: http://etd.cput.ac.za/handle/20.500.11838/1570

► Background. Ultrasound has until recently been regarded as a sophisticated examination reserved for tertiary health care. In reality it is well suited to the district… (more)

▼ Background. Ultrasound has until recently been regarded as a sophisticated examination reserved for tertiary health care. In reality it is well suited to the district or primary health-care situation. A DVT (deep vein thrombosis) is an important complication of the treatment of TB and this can lead to more devastating sequelae such as a pulmonary embolus. Many DVTs are clinically silent, making the diagnosis difficult. Method. This study was a prospective, longitudinal observational study. The study documented the incidence of DVTs and their onset, assessed certain aspects in an attempt to identify some risk factors, and noted the most common position of the DVT in a TB population. The feasibility of a sonographer-led ultrasound clinic for the diagnosis of DVTs was also assessed. This was achieved by screening the in-patient population at a district TB hospital. The participants received up to four routine duplex Doppler compression ultrasound examinations of the venous system of the lower extremities on week 0, week 4, week 8 and week 14. In addition a single abdominal ultrasound was performed at week 0. Results The incidence of DVTs in this TB population was 15.3%. A median of day 10 from commencing TB treatment was identified as the most common day to develop a DVT. The popliteal vein was the most frequent position for a DVT. Several statistically significant factors were identified, including a decreased ambulatory status, TB regimen and the use of anticoagulants. Only 52% of the DVTs were clinically symptomatic. The clinical evaluation for a DVT diagnosis in this study population had a sensitivity of 52.4% and a specificity of 65.3%. The positive predictive value (PPV) was 21.7%. Of the abdominal ultrasound reports there were 75.5% (281) abnormal reports, 22.5% (n = 90) normal reports and 4.5% (n = 18) with no report. Conclusion This body of work has shown how an effective ultrasound service can be provided at a district level TB hospital successfully administered by a trained ultrasonographer. This also facilitated a screening service to diagnose both symptomatic and asymptomatic deep vein thromboses in newly diagnosed tuberculosis patients. This study confirmed a higher rate of DVT in newly diagnosed TB patients than has been previously seen. It also provided detail on additional risk factors. The study illustrates the poor performance of clinical signs and symptoms as a trigger for further investigation for the confirmation of a DVT. Given the frequency and impact of the embolic complications of DVT, this study provides a strong justification for further research into routine serial ultrasonic screening and/or prophylactic antithrombolytics in newly diagnosed TB patients. As well as the DVT ultrasound scans there was the ancillary service offered by the research sonographers. This included an abdominal scan that detected abdominal pathology in 75% of the scans performed. An ultrasound scan is not pathognomonic but it does provide significant insight into the extent of some of the abdominal pathologies seen…

Subjects/Keywords: Doppler ultrasonagraphy – South Africa; Diagnostic ultrasound – South Africa; Venous thromboses; Thombosis; Tuberculosis; Deep vein thrombosis (DVT); Dissertations, Academic; DTech

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brock, S. A. (2013). Compression and Doppler ultrasound of deep vein thrombosis in patients on tuberculosis treatment . (Thesis). Cape Peninsula University of Technology. Retrieved from http://etd.cput.ac.za/handle/20.500.11838/1570

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brock, Sheila Anne. “Compression and Doppler ultrasound of deep vein thrombosis in patients on tuberculosis treatment .” 2013. Thesis, Cape Peninsula University of Technology. Accessed December 14, 2019. http://etd.cput.ac.za/handle/20.500.11838/1570.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brock, Sheila Anne. “Compression and Doppler ultrasound of deep vein thrombosis in patients on tuberculosis treatment .” 2013. Web. 14 Dec 2019.

Vancouver:

Brock SA. Compression and Doppler ultrasound of deep vein thrombosis in patients on tuberculosis treatment . [Internet] [Thesis]. Cape Peninsula University of Technology; 2013. [cited 2019 Dec 14]. Available from: http://etd.cput.ac.za/handle/20.500.11838/1570.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brock SA. Compression and Doppler ultrasound of deep vein thrombosis in patients on tuberculosis treatment . [Thesis]. Cape Peninsula University of Technology; 2013. Available from: http://etd.cput.ac.za/handle/20.500.11838/1570

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. López Chicharro, José. Upper extremity deep vein thrombosis in a triathlete: Again intense endurance exercise as a thrombogenic risk.

Degree: 2018, American Journal of Emergency Medicine

URL: http://hdl.handle.net/10641/1313

Subjects/Keywords: Triathlon; Endurance exercise; Deep vein thrombosis; Tromboembolism; Paget-Schroetter

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

López Chicharro, J. (2018). Upper extremity deep vein thrombosis in a triathlete: Again intense endurance exercise as a thrombogenic risk. (Thesis). American Journal of Emergency Medicine. Retrieved from http://hdl.handle.net/10641/1313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

López Chicharro, José. “Upper extremity deep vein thrombosis in a triathlete: Again intense endurance exercise as a thrombogenic risk.” 2018. Thesis, American Journal of Emergency Medicine. Accessed December 14, 2019. http://hdl.handle.net/10641/1313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

López Chicharro, José. “Upper extremity deep vein thrombosis in a triathlete: Again intense endurance exercise as a thrombogenic risk.” 2018. Web. 14 Dec 2019.

Vancouver:

López Chicharro J. Upper extremity deep vein thrombosis in a triathlete: Again intense endurance exercise as a thrombogenic risk. [Internet] [Thesis]. American Journal of Emergency Medicine; 2018. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10641/1313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

López Chicharro J. Upper extremity deep vein thrombosis in a triathlete: Again intense endurance exercise as a thrombogenic risk. [Thesis]. American Journal of Emergency Medicine; 2018. Available from: http://hdl.handle.net/10641/1313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Kurstjens, Ralph Lambertus Maria. Haemodynamics in deep venous obstruction: Advances towards a tailored treatment.

Degree: 2016, Maastricht University

URL: https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; urn:isbn:978-94-6182-744-9 ; urn:isbn:978-94-6182-744-9 ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html

► Each year, 1–2 out of every 1,000 people develop deep vein thrombosis. Of the people who develop the condition, 25–56% suffer from chronic symptoms that… (more)

Subjects/Keywords: deep vein thrombosis; treatment; stents; quality of life

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kurstjens, R. L. M. (2016). Haemodynamics in deep venous obstruction: Advances towards a tailored treatment. (Doctoral Dissertation). Maastricht University. Retrieved from https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; urn:isbn:978-94-6182-744-9 ; urn:isbn:978-94-6182-744-9 ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html

Chicago Manual of Style (16^th Edition):

Kurstjens, Ralph Lambertus Maria. “Haemodynamics in deep venous obstruction: Advances towards a tailored treatment.” 2016. Doctoral Dissertation, Maastricht University. Accessed December 14, 2019. https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; urn:isbn:978-94-6182-744-9 ; urn:isbn:978-94-6182-744-9 ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html.

MLA Handbook (7^th Edition):

Kurstjens, Ralph Lambertus Maria. “Haemodynamics in deep venous obstruction: Advances towards a tailored treatment.” 2016. Web. 14 Dec 2019.

Vancouver:

Kurstjens RLM. Haemodynamics in deep venous obstruction: Advances towards a tailored treatment. [Internet] [Doctoral dissertation]. Maastricht University; 2016. [cited 2019 Dec 14]. Available from: https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; urn:isbn:978-94-6182-744-9 ; urn:isbn:978-94-6182-744-9 ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html.

Council of Science Editors:

Kurstjens RLM. Haemodynamics in deep venous obstruction: Advances towards a tailored treatment. [Doctoral Dissertation]. Maastricht University; 2016. Available from: https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; urn:isbn:978-94-6182-744-9 ; urn:isbn:978-94-6182-744-9 ; urn:nbn:nl:ui:27-f638a8a6-2f4c-457a-bc5b-bd8da2820d3c ; https://cris.maastrichtuniversity.nl/portal/en/publications/haemodynamics-in-deep-venous-obstruction(f638a8a6-2f4c-457a-bc5b-bd8da2820d3c).html

Georgia Tech

27. Sathe, Rahul D. Design and Development of a Novel Implantable Prosthetic Vein Valve.

Degree: MS, Mechanical Engineering, 2006, Georgia Tech

URL: http://hdl.handle.net/1853/14495

► Over seven million Americans suffer from Chronic Venous Insufficiency (CVI), a painful and debilitating disease that affects the superficial and deep veins of the legs.… (more)

▼ Over seven million Americans suffer from Chronic Venous Insufficiency (CVI), a painful and debilitating disease that affects the superficial and deep veins of the legs. Problems associated with CVI include varicose veins, bleeding, ulcerations, severe swelling, deep vein thrombosis, and pulmonary embolism, which may lead to death. The presence of CVI results from damaged (incompetent) one-way vein valves in leg veins. These valves normally allow forward flow of blood to the heart, and prevent blood from pooling at the feet. However, incompetent valves allow reflux of blood, causing clinical problems. There are few effective clinical therapies for treating CVI. Vein valve transplantation is a surgical option for treatment. However, it is often difficult to find suitable donor valves. Very few prosthetic valves developed in the past have demonstrated sufficient clinical or mechanical functionality. Persistent problems include thrombus formation, leaking valves, and valves that do not open at physiologic pressure gradient. The primary objective of this research was to develop a clinically relevant functional prosthetic vein valve. The novel prosthetic valve is flexible, biocompatible, has low thrombogenecity, and is easy to manufacture. It was designed to address well-defined consumer needs and functional design requirements. The valve was required to 1) withstand 300 mmHg of backpressure with leakage less than 1.0 mL/min, 2) open with a pressure gradient less than 5 mmHg, and 3) meet criteria 1 and 2 after 500,000 cycles of operation. The valve met these design requirements in bench testing. The valve can open with a pressure gradient of 2.6 0.7 mmHg, and can withstand 300 mmHg with leakage less than 0.5 mL/min. The valve remained functional after opening and closing over 500,000 times. The valve presented in this research is operationally functional, and is a potential solution for treating venous incompetence in CVI patients. Advisors/Committee Members: Dr. David N. Ku (Committee Chair), Dr. David Rosen (Committee Member), Dr. Elliot Chaikof (Committee Member).

Subjects/Keywords: Vein valve; Deep vein thrombosis; Venous valve; Prosthetic vein valve; Chronic venous insufficiency; Implants, Artificial Design and construction; Venous valves Transplantation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sathe, R. D. (2006). Design and Development of a Novel Implantable Prosthetic Vein Valve. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/14495

Chicago Manual of Style (16^th Edition):

Sathe, Rahul D. “Design and Development of a Novel Implantable Prosthetic Vein Valve.” 2006. Masters Thesis, Georgia Tech. Accessed December 14, 2019. http://hdl.handle.net/1853/14495.

MLA Handbook (7^th Edition):

Sathe, Rahul D. “Design and Development of a Novel Implantable Prosthetic Vein Valve.” 2006. Web. 14 Dec 2019.

Vancouver:

Sathe RD. Design and Development of a Novel Implantable Prosthetic Vein Valve. [Internet] [Masters thesis]. Georgia Tech; 2006. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/1853/14495.

Council of Science Editors:

Sathe RD. Design and Development of a Novel Implantable Prosthetic Vein Valve. [Masters Thesis]. Georgia Tech; 2006. Available from: http://hdl.handle.net/1853/14495

28. Cornudella Lacasa, Rosa María. Variantes genéticas de trombofilia en pacientes jóvenes con enfermedad tromboembólica venosa.

Degree: 2016, Universidad de Zaragoza, Prensas de la Universidad

URL: http://zaguan.unizar.es/record/56350

► La Enfermedad tromboembólica venosa (ETEV) es una de las principales causas de morbimortalidad en los países desarrollados. Engloba principalmente a la Trombosis Venosa Profunda (TVP)… (more)

▼ La Enfermedad tromboembólica venosa (ETEV) es una de las principales causas de morbimortalidad en los países desarrollados. Engloba principalmente a la Trombosis Venosa Profunda (TVP) y la embolia de pulmón. Enfermedad multifactorial y compleja donde intervienen numerosos factores genéticos y ambientales. Una de sus causas es la Trombofilia, cuyo estudio se centra principalmente en la mutación FVL y en la PT G20210A. En la actualidad se reconocen otras variantes genéticas relacionadas con la hemostasia como posibles factores de riesgo (FR) de ETEV. Objetivo principal: Identificar las variantes genéticas de trombofilia presentes en los pacientes jóvenes de nuestro medio y determinar su prevalencia. Objetivos secundarios: Describir y analizar las características clínicas, analíticas, FR y otros procesos asociados de ETEV. POBLACIÓN, MATERIAL Y MÉTODOS: Estudio observacional, retrospectivo, unicéntrico de casos control en el que se han incluido 198 individuos con edad ≤ 50 años del Hospital Clínico Universitario Lozano Blesa desde 2009 al primer semestre de 2015, distribuidos en grupo de pacientes (53 varones y 68 mujeres con diagnóstico de ETEV con anticoagulación oral) y grupo control (19 varones y 58 mujeres) de los que hemos recogido datos demográficos, analíticos generales y de trombofilia plasmática (Déficit de AT, PC y PS y RPCa), genética [(FVL, PT20210A ,FVL H1299, MTHFR mutación C677T, MTHFR A1298C, Factor XIII V34L, BFG 455G>A, PAI-1 4G/5G, ITGB3 (HPA1 a/b), ECA I/D, APOB R3500Q y APOE (E2,E3,E4)] y adquirida (Anticoagulante lúpico y Anticuerpos antifosfolípidos e hiperhomocisteina). En el grupo de pacientes hemos valorado además, antecedentes familiares (AF), evento, presentación, FR clásicos y otros procesos asociados de ETEV. El tratamiento estadístico descriptivo y comparativo de los datos se realizó con el “PASW Statistic v.18.0.0 (SPSS Inc.)”. RESULTADOS Y DISCUSIÓN La ETEV en nuestros pacientes se presentó a la edad media de 37.79 años y predominio femenino. Todos los individuos presentaron al menos una de las mutaciones estudiadas. En el grupo de pacientes el 84 % portaban más mutación clásica (AT, PC, PS, RPCa, FVL y PT20210A). El evento más frecuente fue la TVP de extremidades inferiores (25.3%) de acuerdo con otros estudios. El 5.8% presentaron AF. El 52.1% fueron provocadas por un FR clásico a diferencia de otros datos publicados en la bibliografía. El 48% de los pacientes portadores de una trombofilia clásica presentaron una ETEV espontánea y el 7.5% no presentaron FR asociados. El FR más frecuente fueron los traumatismos (13.2%) y el proceso asociado, el hábito tabáquico (18.2%), no presentando ninguno más de 3 FR. Se encontraron diferencias estadísticamente significativas entre FVL asociado o no a RPCa y el grupo de pacientes (OR: 11.58) y entre el haplotipo HR2 y el grupo control. No se encontraron diferencias significativas en el resto de parámetros estudiados. CONCLUSIONES: todos los pacientes presentaron al menos una de las variantes genéticas estudiadas. La significación estadística y…

Subjects/Keywords: trombosis; genética; hematología

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cornudella Lacasa, R. M. (2016). Variantes genéticas de trombofilia en pacientes jóvenes con enfermedad tromboembólica venosa. (Thesis). Universidad de Zaragoza, Prensas de la Universidad. Retrieved from http://zaguan.unizar.es/record/56350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cornudella Lacasa, Rosa María. “Variantes genéticas de trombofilia en pacientes jóvenes con enfermedad tromboembólica venosa.” 2016. Thesis, Universidad de Zaragoza, Prensas de la Universidad. Accessed December 14, 2019. http://zaguan.unizar.es/record/56350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cornudella Lacasa, Rosa María. “Variantes genéticas de trombofilia en pacientes jóvenes con enfermedad tromboembólica venosa.” 2016. Web. 14 Dec 2019.

Vancouver:

Cornudella Lacasa RM. Variantes genéticas de trombofilia en pacientes jóvenes con enfermedad tromboembólica venosa. [Internet] [Thesis]. Universidad de Zaragoza, Prensas de la Universidad; 2016. [cited 2019 Dec 14]. Available from: http://zaguan.unizar.es/record/56350.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cornudella Lacasa RM. Variantes genéticas de trombofilia en pacientes jóvenes con enfermedad tromboembólica venosa. [Thesis]. Universidad de Zaragoza, Prensas de la Universidad; 2016. Available from: http://zaguan.unizar.es/record/56350

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Santiago Ramajo, Sandra. Evaluación neuropsicológica y de calidad de vida en pacientes con hemorragia subaracnoidea aneurismática.

Degree: 2018, Granada: Universidad de Granada

URL: http://hdl.handle.net/10481/2592

Tesis Univ. Granada. Departamento de Personalidad, Evaluación y Tratamiento Psicológico. Leída el 1 de octubre de 2009 Advisors/Committee Members: Katati, Majed J., Pérez García, Miguel, Universidad de Granada. Departamento de Personalidad, Evaluación y Tratamiento Psicológico.

Subjects/Keywords: Hemorragia; Neuropsicología; Trombosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santiago Ramajo, S. (2018). Evaluación neuropsicológica y de calidad de vida en pacientes con hemorragia subaracnoidea aneurismática. (Thesis). Granada: Universidad de Granada. Retrieved from http://hdl.handle.net/10481/2592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Santiago Ramajo, Sandra. “Evaluación neuropsicológica y de calidad de vida en pacientes con hemorragia subaracnoidea aneurismática.” 2018. Thesis, Granada: Universidad de Granada. Accessed December 14, 2019. http://hdl.handle.net/10481/2592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Santiago Ramajo, Sandra. “Evaluación neuropsicológica y de calidad de vida en pacientes con hemorragia subaracnoidea aneurismática.” 2018. Web. 14 Dec 2019.

Vancouver:

Santiago Ramajo S. Evaluación neuropsicológica y de calidad de vida en pacientes con hemorragia subaracnoidea aneurismática. [Internet] [Thesis]. Granada: Universidad de Granada; 2018. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/10481/2592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santiago Ramajo S. Evaluación neuropsicológica y de calidad de vida en pacientes con hemorragia subaracnoidea aneurismática. [Thesis]. Granada: Universidad de Granada; 2018. Available from: http://hdl.handle.net/10481/2592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Pasha, Sharif Mohammed. Venous and arterial thromboembolism: prevention and prognosis.

Degree: 2015, Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University

URL: http://hdl.handle.net/1887/35978

► This thesis is a journey in the vascular medicine. Chapter 1 is a general introduction. Chapter 2 is a meta-analysis on the diagnosis of pulmonary… (more)

Subjects/Keywords: Pulmonary-embolism; Deep-vein-thrombosis; Atherothrombotic-events; Contrast-induced-nephropathy; Pulmonary-embolism; Deep-vein-thrombosis; Atherothrombotic-events; Contrast-induced-nephropathy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pasha, S. M. (2015). Venous and arterial thromboembolism: prevention and prognosis. (Doctoral Dissertation). Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University. Retrieved from http://hdl.handle.net/1887/35978

Chicago Manual of Style (16^th Edition):

Pasha, Sharif Mohammed. “Venous and arterial thromboembolism: prevention and prognosis.” 2015. Doctoral Dissertation, Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University. Accessed December 14, 2019. http://hdl.handle.net/1887/35978.

MLA Handbook (7^th Edition):

Pasha, Sharif Mohammed. “Venous and arterial thromboembolism: prevention and prognosis.” 2015. Web. 14 Dec 2019.

Vancouver:

Pasha SM. Venous and arterial thromboembolism: prevention and prognosis. [Internet] [Doctoral dissertation]. Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University; 2015. [cited 2019 Dec 14]. Available from: http://hdl.handle.net/1887/35978.

Council of Science Editors:

Pasha SM. Venous and arterial thromboembolism: prevention and prognosis. [Doctoral Dissertation]. Department of Thrombosis and Hemostasis, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University; 2015. Available from: http://hdl.handle.net/1887/35978

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