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University of Edinburgh
1.
Howarth, Amelia Rose.
The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.
Degree: PhD, 2020, University of Edinburgh
URL: http://hdl.handle.net/1842/36788 
► Chronic kidney disease (CKD) is a global disease affecting 10% of the world population and is largely treated by dialysis and organ transplant at late…
(more)
▼ Chronic kidney disease (CKD) is a global disease affecting 10% of the world population and is largely treated by dialysis and organ transplant at late stages of disease. As rates of CKD rise, it is increasingly evident that novel drug targets are required for intervention before these late stages are reached. The purinergic receptor sub-type 7 (P2X7) may represent such a drug target. P2X7, an ATP-gated ion channel, is part of the purinergic signalling pathway and antagonists are safe and well-tolerated in clinical trials as a treatment for inflammatory disease. These trials did not show therapeutic benefit, but recent findings suggest that vascular, rather than immune, functions of P2X7 may be important for renal disease. This project aimed to investigate the expression and role of P2X7 in the renal vasculature in both normal and hypertensive mice. A mouse model of multi-hit renal vascular injury was established and characterised through the administration of angiotensin II (ANGII), deoxycorticosterone (DOCA) and a high salt diet (ANGII DOCA salt model). ANGII DOCA salt mice exhibited mild hypertension, moderate albuminuria, vascular dysfunction, perivascular fibrosis, and a marked increase in renal injury markers in both whole kidney and urine, compared to sham-operated (Sham) littermates. A systematic immunofluorescence study localised P2X7 to the endothelium of renal vessels and glomerular capillaries in both Sham and ANGII DOCA salt mice, as well as localising to areas of injury in ANGII DOCA salt mouse kidneys. The P2X7 antagonist A438079 was able to inhibit ATP-stimulated release of IL-1B in LPS-primed mouse macrophages and was therefore used to assess vascular function in isolated aorta by wire myography. These studies found that activation of P2X7 via agonist BzATP led to vasoconstriction in both mouse groups, an effect that was amplified upon P2X7 inhibitions. Following these findings, it is possible that this is due to a shift in the expression of different P2X7 isoforms with potentially opposing vasoactivity in ANGII DOCA salt mice, compared to Sham mice. This is supported by the observation of differential expression of P2X7 according to the tissue used, the method of detection used, and the disease model investigated. This thesis highlights the importance of considering splice variation under normo- and pathophysiological conditions, both their expressional and functional differences.
Subjects/Keywords: chronic kidney disease; CKD; P2X7; P2X7 isoforms
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APA (6th Edition):
Howarth, A. R. (2020). The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/36788
Chicago Manual of Style (16th Edition):
Howarth, Amelia Rose. “The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed February 27, 2021.
http://hdl.handle.net/1842/36788.
MLA Handbook (7th Edition):
Howarth, Amelia Rose. “The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.” 2020. Web. 27 Feb 2021.
Vancouver:
Howarth AR. The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1842/36788.
Council of Science Editors:
Howarth AR. The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: http://hdl.handle.net/1842/36788
University of Edinburgh
2.
Howarth, Amelia Rose.
The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.
Degree: PhD, 2020, University of Edinburgh
URL: https://doi.org/10.7488/era/93
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799016
► Chronic kidney disease (CKD) is a global disease affecting 10% of the world population and is largely treated by dialysis and organ transplant at late…
(more)
▼ Chronic kidney disease (CKD) is a global disease affecting 10% of the world population and is largely treated by dialysis and organ transplant at late stages of disease. As rates of CKD rise, it is increasingly evident that novel drug targets are required for intervention before these late stages are reached. The purinergic receptor sub-type 7 (P2X7) may represent such a drug target. P2X7, an ATP-gated ion channel, is part of the purinergic signalling pathway and antagonists are safe and well-tolerated in clinical trials as a treatment for inflammatory disease. These trials did not show therapeutic benefit, but recent findings suggest that vascular, rather than immune, functions of P2X7 may be important for renal disease. This project aimed to investigate the expression and role of P2X7 in the renal vasculature in both normal and hypertensive mice. A mouse model of multi-hit renal vascular injury was established and characterised through the administration of angiotensin II (ANGII), deoxycorticosterone (DOCA) and a high salt diet (ANGII DOCA salt model). ANGII DOCA salt mice exhibited mild hypertension, moderate albuminuria, vascular dysfunction, perivascular fibrosis, and a marked increase in renal injury markers in both whole kidney and urine, compared to sham-operated (Sham) littermates. A systematic immunofluorescence study localised P2X7 to the endothelium of renal vessels and glomerular capillaries in both Sham and ANGII DOCA salt mice, as well as localising to areas of injury in ANGII DOCA salt mouse kidneys. The P2X7 antagonist A438079 was able to inhibit ATP-stimulated release of IL-1B in LPS-primed mouse macrophages and was therefore used to assess vascular function in isolated aorta by wire myography. These studies found that activation of P2X7 via agonist BzATP led to vasoconstriction in both mouse groups, an effect that was amplified upon P2X7 inhibitions. Following these findings, it is possible that this is due to a shift in the expression of different P2X7 isoforms with potentially opposing vasoactivity in ANGII DOCA salt mice, compared to Sham mice. This is supported by the observation of differential expression of P2X7 according to the tissue used, the method of detection used, and the disease model investigated. This thesis highlights the importance of considering splice variation under normo- and pathophysiological conditions, both their expressional and functional differences.
Subjects/Keywords: chronic kidney disease; CKD; P2X7; P2X7 isoforms
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APA ·
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APA (6th Edition):
Howarth, A. R. (2020). The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. (Doctoral Dissertation). University of Edinburgh. Retrieved from https://doi.org/10.7488/era/93 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799016
Chicago Manual of Style (16th Edition):
Howarth, Amelia Rose. “The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed February 27, 2021.
https://doi.org/10.7488/era/93 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799016.
MLA Handbook (7th Edition):
Howarth, Amelia Rose. “The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease.” 2020. Web. 27 Feb 2021.
Vancouver:
Howarth AR. The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Feb 27].
Available from: https://doi.org/10.7488/era/93 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799016.
Council of Science Editors:
Howarth AR. The role of the P2X7 receptor in the renal vasculature in a mouse model of chronic kidney disease. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: https://doi.org/10.7488/era/93 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799016
3.
Alba Huizar, Michael.
Chronic kidney disease prevention in the Hispanic/Latino community: SF Mission District.
Degree: MPH, 2020, University of San Francisco
URL: https://repository.usfca.edu/capstone/1079
► Chronic kidney disease (CKD) is a growing medical condition that affects many Americans; however, the largest minority group living in the US, Hispanic/Latinos, are…
(more)
▼ Chronic kidney disease (CKD) is a growing medical condition that affects many Americans; however, the largest minority group living in the US, Hispanic/Latinos, are suffering the most complications associated with the disease. Multiple research has concluded that due to barriers such as poverty, limited education, and limited English proficiency, it has prevented many Hispanic/Latinos from knowing their disease status. My internship at the Community Health Resource Center was to create a CKD campaign in Spanish that targets the Hispanic/Latino community living in San Francisco's Mission District. As well, the Campaign's goal was to tackle the challenges that prevent Hispanic/Latinos in the Mission District from understanding their kidney health. The Campaign gathered pertinent health information from the National Kidney Foundation, the American Heart Association, the CDC, the American Diabetes Association, and various evidence-based research to create lectures in Spanish. As mentioned by multiple studies, when individuals are presented with educational material that is easy to understand and in a preferred language, they become more receptive to learning, asking questions, and being proactive in managing their health. Although the Campaign had some challenges due to the COVID-19 pandemic, it continued via a virtual route using Zoom. Results concluded that there is still a huge need for free culturally and linguistically appropriate educational workshops and health screenings. When communities are presented with free workshops, such as a CKD campaign, they attend and are willing to learn.
Subjects/Keywords: Chronic Kidney Disease; CKD; Hispanic; Latinos
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APA (6th Edition):
Alba Huizar, M. (2020). Chronic kidney disease prevention in the Hispanic/Latino community: SF Mission District. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/capstone/1079
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alba Huizar, Michael. “Chronic kidney disease prevention in the Hispanic/Latino community: SF Mission District.” 2020. Thesis, University of San Francisco. Accessed February 27, 2021.
https://repository.usfca.edu/capstone/1079.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alba Huizar, Michael. “Chronic kidney disease prevention in the Hispanic/Latino community: SF Mission District.” 2020. Web. 27 Feb 2021.
Vancouver:
Alba Huizar M. Chronic kidney disease prevention in the Hispanic/Latino community: SF Mission District. [Internet] [Thesis]. University of San Francisco; 2020. [cited 2021 Feb 27].
Available from: https://repository.usfca.edu/capstone/1079.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alba Huizar M. Chronic kidney disease prevention in the Hispanic/Latino community: SF Mission District. [Thesis]. University of San Francisco; 2020. Available from: https://repository.usfca.edu/capstone/1079
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Boston University
4.
Belding, Emily.
A review of the implications of chronic kidney disease in pregnancy on maternal and fetal outcomes.
Degree: MS, Medical Sciences, 2020, Boston University
URL: http://hdl.handle.net/2144/41185
► The prevalence of pregnancies complicated by chronic kidney disease (CKD) is increasing. Yet, CKD in pregnancy tends to be under-diagnosed, as women of childbearing age…
(more)
▼ The prevalence of pregnancies complicated by
chronic kidney disease (
CKD) is increasing. Yet,
CKD in pregnancy tends to be under-diagnosed, as women of childbearing age are not regularly screened for renal dysfunction, nor is screening incorporated into routine pregnancy follow up. Further, renal dysfunction has significant implications for maternal and fetal outcomes, with degree of renal dysfunction at conception being the most important prognostic factor. It is established that the risk for poorer renal, maternal and fetal outcomes, increases incrementally with severity of
CKD, with intrauterine death and progression to end-stage renal
disease (ESDR) associated with severe
CKD. However, it is difficult to predict which
CKD pregnancies will lead to poor outcomes as the definition of
CKD in pregnancy is not uniform between studies, nor are measurement parameters. This paucity of data prevents the establishment of a standard of care protocol and leaves clinicians ill-equipped to care for and manage this complex patient cohort. This review discusses renal, maternal and fetal outcomes in
CKD pregnancies as presented by the literature, in order to demonstrate the contradictions in data and gaps in knowledge surrounding this topic, as well as the need for a general management algorithm.
Advisors/Committee Members: Garcia-Diaz, J. Fernando (advisor), Moussavi, Mina (advisor).
Subjects/Keywords: Physiology; Chronic kidney disease (CKD); CKD in Pregnancy; CKD management; Maternal outcomes
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APA ·
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APA (6th Edition):
Belding, E. (2020). A review of the implications of chronic kidney disease in pregnancy on maternal and fetal outcomes. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41185
Chicago Manual of Style (16th Edition):
Belding, Emily. “A review of the implications of chronic kidney disease in pregnancy on maternal and fetal outcomes.” 2020. Masters Thesis, Boston University. Accessed February 27, 2021.
http://hdl.handle.net/2144/41185.
MLA Handbook (7th Edition):
Belding, Emily. “A review of the implications of chronic kidney disease in pregnancy on maternal and fetal outcomes.” 2020. Web. 27 Feb 2021.
Vancouver:
Belding E. A review of the implications of chronic kidney disease in pregnancy on maternal and fetal outcomes. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2144/41185.
Council of Science Editors:
Belding E. A review of the implications of chronic kidney disease in pregnancy on maternal and fetal outcomes. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41185
University of California – San Francisco
5.
Madi, Iman Moha.
Effects of Non-Surgical Periodontal Treatment on Chronic Kidney Disease Parameters: A Randomized clinical Trial.
Degree: Oral and Craniofacial Sciences, 2018, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/6qb8p530
► Chronic Kidney disease (CKD) is a broad spectrum of several conditions affecting 26 million American. Over 67 million adults 30 years or older are suffering…
(more)
▼ Chronic Kidney disease (CKD) is a broad spectrum of several conditions affecting 26 million American. Over 67 million adults 30 years or older are suffering from periodontal disease. Both conditions are influenced by many confounding conditions such as diabetes, smoking, stress and other inflammatory conditions. Current evidence shows a possible associated between CKD and periodontal disease. The purpose of this study was to see if treatment of periodontal disease in low socioeconomic patients with CKD and periodontal disease can have a positive effect on CKD parameters. 46 patients qualified for and completed this study. Patients were divided into an intervention and a control group and were examined at baseline, 4 months, 8 months and 12 months. Various kidney function parameters were also recorded through blood and urine samples at these appointments. The periodontal condition of the intervention group was treated with scaling and root planing, extractions and local delivery of minocycline polymers in probing pocket depths of 5mm or more and oral hygiene instruction. The control group was only given oral hygiene instruction handouts during these visits and extraction of their hopeless teeth. The control group received SRP and minocycline administration at the conclusion of the study. Both groups showed improvements in probing pocket depths, clinical attachment levels, bleeding on probing, plaque index and gingival index. These trends were stronger in the intervention group but not enough to be considered as healthy periodontium. Thus, the improvement in the periodontal state was not adequate enough to be assessed for influencing the kidney parameters. There was no difference between the two groups in kidney parameters.
Subjects/Keywords: Dentistry; Chronic Kidney Disease; CKD; Dentistry; Periodontal disease; Periodontal treatment; Periodontitis
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APA ·
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APA (6th Edition):
Madi, I. M. (2018). Effects of Non-Surgical Periodontal Treatment on Chronic Kidney Disease Parameters: A Randomized clinical Trial. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/6qb8p530
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Madi, Iman Moha. “Effects of Non-Surgical Periodontal Treatment on Chronic Kidney Disease Parameters: A Randomized clinical Trial.” 2018. Thesis, University of California – San Francisco. Accessed February 27, 2021.
http://www.escholarship.org/uc/item/6qb8p530.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Madi, Iman Moha. “Effects of Non-Surgical Periodontal Treatment on Chronic Kidney Disease Parameters: A Randomized clinical Trial.” 2018. Web. 27 Feb 2021.
Vancouver:
Madi IM. Effects of Non-Surgical Periodontal Treatment on Chronic Kidney Disease Parameters: A Randomized clinical Trial. [Internet] [Thesis]. University of California – San Francisco; 2018. [cited 2021 Feb 27].
Available from: http://www.escholarship.org/uc/item/6qb8p530.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Madi IM. Effects of Non-Surgical Periodontal Treatment on Chronic Kidney Disease Parameters: A Randomized clinical Trial. [Thesis]. University of California – San Francisco; 2018. Available from: http://www.escholarship.org/uc/item/6qb8p530
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Staykova, Svetla / Стайкова, Светла.
Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение.
Degree: 2018, Medical University of Varna
URL: http://repository.mu-varna.bg/handle/nls/403
► [EN] Purpose of the dissertation thesis is to analyse the diagnostic, clinical and therapeutic aspects of BMD-CKD in the course of conservative and haemodialysis treatment…
(more)
▼ [EN] Purpose of the dissertation thesis is to analyse the diagnostic, clinical and therapeutic aspects of BMD-CKD in the course of conservative and haemodialysis treatment by examining the diagnostic and prognostic value of contemporary biomarkers for the development of secondary hyperparathyroidism and BMD-CKD; imaging studies of variations of the parathyroid gland and bone-dental changes; comparison of the clinical efficacy of calcimimetics and paricalcitol in the development of sHPT and BMD; analysis of the dynamic influence of phosphor-binding binders on markers of BMD-CKD; traceability and safety; appreciation of combination treatment with vit.K2 and calcitriol; examining individual quality of life and developing an algorithm for BMD-CKD. The study was conducted between 1.1.2015 and 31.12.2017 with 338 patients with CKD and on HD in St.Marina University Hospital - Varna. The work proves the diagnostic and prognostic value of the complex analysis of the indicators BMD-CKD as a result of medication and HD treatment; elevated levels of FGF-23 at an early stage represent a prognostic marker for risk of cardiovascular diseases; increased levels of OC and BAP in HD with high level of PTH testify to HTBD-sHPT. Image studies for evaluation of parathyroid glands in sHPT have a significant role. Calcimimetic and paricalcitol suppress the secretion of PTH and shorten period of hyper Ca. Renagel is shown to control hyper P and a decrease FGF-23. Vit.K2 may be combined with medications used to treat BMD and protect against calcifications. Dental changes change BMD and should be treated. The questionnaire and algorithm we have modified is a reliable basis for a complex and individualized approach. /////////////// /////////////// [BG] Цел на дисертационната разработка е анализ на диагностичните, клинични и терапевтични аспекти на КМН-ХБЗ в хода на консервативното и хемодиализно лечение чрез изследване на диагностичната и прогностична стойност на съвременни биомаркери за развитие на вторичен хиперпаратиреоидизъм и КМН-ХБЗ; образни изследвания на измененията на ПЩЖ и костно-дентални промени; съпоставка на клиничната ефективност на калцимиметици и парикалцитол при развитието на ВтХПТ и КМН-ХБЗ; анализ на динамичното влияние на фосфор-свързващите байндери върху маркери на КМН-ХБЗ; проследена ефективност и безопасност; апробиране комбинираното лечение с вит.К2 и калцитриол; изследване на индивидуално качество на живот и разработване на алгоритъм за КМН-ХБЗ. Изследването е проведено между 1.1.2015 и 31.12.2017 с 338 болни с ХБЗ и на ХД в УМБАЛ „Св. Марина“–Варна. Трудът доказва диагностично-прогностичната стойност на комплексното анализиране на показателите КМН-ХБЗ в резултат на медикаментозно и ХД лечение; Повишените нива на FGF-23 в ранен стадий представляват прогностичен маркер за риска от ССЗ; Повишените нива на ОК и ВАР при ХД с висок ПТХ свидетелстват за HTBD-sHPT. Образните изследвания за оценка на ПТЖ при ВтХПТ имат значима роля. Калцимиметици и парикалцитол потискат секрецията на ПТХ и скъсяват периода на хипер Ca. Ренагел…
Subjects/Keywords: chronic kidney disease (CKD); haemodialysis; hyperparathyroidism; mineral; bone disorder; Нефрология / Nephrology
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APA ·
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Manager
APA (6th Edition):
Staykova, Svetla / Стайкова, . (2018). Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/403
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Staykova, Svetla / Стайкова, Светла. “Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение.” 2018. Thesis, Medical University of Varna. Accessed February 27, 2021.
http://repository.mu-varna.bg/handle/nls/403.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Staykova, Svetla / Стайкова, Светла. “Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение.” 2018. Web. 27 Feb 2021.
Vancouver:
Staykova, Svetla / Стайкова . Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение. [Internet] [Thesis]. Medical University of Varna; 2018. [cited 2021 Feb 27].
Available from: http://repository.mu-varna.bg/handle/nls/403.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Staykova, Svetla / Стайкова . Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение. [Thesis]. Medical University of Varna; 2018. Available from: http://repository.mu-varna.bg/handle/nls/403
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Lund
7.
Schulz, Christina-Alexandra.
The role of circulating biomarkers, genetics, and diet in
kidney function.
Degree: 2017, University of Lund
URL: https://lup.lub.lu.se/record/783aca21-3396-4cd2-a11e-1a57c46db47d
;
https://portal.research.lu.se/ws/files/39904684/Thesis_Christina_AlexandraSchulz.pdf
► Today, between 8% and 16% of all individuals worldwide suffer from chronic kidney disease (CKD), which is becoming a growing public health issue. Creatinine and…
(more)
▼ Today, between 8% and 16% of all individuals
worldwide suffer from chronic kidney disease (CKD), which is
becoming a growing public health issue. Creatinine and cystatin C
are commonly used markers for kidney function, and estimated
glomerular filtration rate (eGFR) and albuminuria are used to stage
CKD. However, creatinine and eGFR are rather insensitive in
identifying individuals at high risk of future CKD. Several
biomarkers have been proposed to play a role, yet the clinical
evidence, particularly from longitudinal studies, is limited.
During the recent years, several genetic markers associated with
kidney function have been identified by genome-wide association
studies. However, the question of whether genetic markers may aid
in improving prediction on the top of the commonly used clinical
risk factors remains open. Environmental factors, such as diet,
have been suggested to be of importance for kidney function, but
current knowledge from individuals free of CKD is
limited.Therefore, this thesis aimed to investigate if 1)
circulating biomarkers (studies I-III) or 2) information on genetic
predisposition (study IV) may show advantages in the prediction of
future kidney function deterioration after a long-term follow-up.
Furthermore, we studied if 3) dietary intake at baseline associates
with future kidney function (study V). The work in this thesis was
conducted within the setting of the Malmö Diet and Cancer Study, a
population-based cohort of middle-aged individuals from Southern
Sweden.In studies I-III we observed that in participants with an
eGFR > 60 mL/min/1.73m2 elevated plasma levels of pro-enkephalin
(study I), soluble urokinase receptor (study II), or kidney injury
molecule-1 (study III), were each associated with an ~20% increased
risk of incident CKD stage 3A per increase in one SD of the
respective biomarker, independently of known risk factors (OR 1.17
95 %CI=1.05-1.30; 1.25 95 %CI=1.10-1.41, and 1.21 95 %CI=1.08-1.34,
respectively).In study IV, we report that adding a genetic risk
score composed of 53 SNPs, previously identified by GWAS to
associate with kidney function, to a risk model including clinical
risk factors, may be helpful in evaluating the risk of incident CKD
(OR per risk allele 1.04, 95%CI 1.01-1.07; NRI 17.7.% P=0.0007).In
study V, we investigated the association between dietary intakes
and occurrence of CKD in participants with a preserved kidney
function at baseline. We investigated reported intakes of 15 food
groups focusing on different sources of protein, and intakes of
macronutrients and three beverages. We observed that lower sucrose
intake as well as higher fiber and coffee intake associated with
favorable long-term kidney function. In conclusion, the studies
included in this PhD-thesis demonstrate that novel circulating and
genetic biomarkers may be clinically useful in estimating future
kidney function, and emphasize genetic susceptibility and diet as
important determinants of longitudinal kidney
function.
Subjects/Keywords: Medical and Health Sciences; biomarker; Chronic kidney disease (CKD); Diet
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APA (6th Edition):
Schulz, C. (2017). The role of circulating biomarkers, genetics, and diet in
kidney function. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/783aca21-3396-4cd2-a11e-1a57c46db47d ; https://portal.research.lu.se/ws/files/39904684/Thesis_Christina_AlexandraSchulz.pdf
Chicago Manual of Style (16th Edition):
Schulz, Christina-Alexandra. “The role of circulating biomarkers, genetics, and diet in
kidney function.” 2017. Doctoral Dissertation, University of Lund. Accessed February 27, 2021.
https://lup.lub.lu.se/record/783aca21-3396-4cd2-a11e-1a57c46db47d ; https://portal.research.lu.se/ws/files/39904684/Thesis_Christina_AlexandraSchulz.pdf.
MLA Handbook (7th Edition):
Schulz, Christina-Alexandra. “The role of circulating biomarkers, genetics, and diet in
kidney function.” 2017. Web. 27 Feb 2021.
Vancouver:
Schulz C. The role of circulating biomarkers, genetics, and diet in
kidney function. [Internet] [Doctoral dissertation]. University of Lund; 2017. [cited 2021 Feb 27].
Available from: https://lup.lub.lu.se/record/783aca21-3396-4cd2-a11e-1a57c46db47d ; https://portal.research.lu.se/ws/files/39904684/Thesis_Christina_AlexandraSchulz.pdf.
Council of Science Editors:
Schulz C. The role of circulating biomarkers, genetics, and diet in
kidney function. [Doctoral Dissertation]. University of Lund; 2017. Available from: https://lup.lub.lu.se/record/783aca21-3396-4cd2-a11e-1a57c46db47d ; https://portal.research.lu.se/ws/files/39904684/Thesis_Christina_AlexandraSchulz.pdf
University of Minnesota
8.
Li, Shuling.
Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.
Degree: PhD, Epidemiology, 2013, University of Minnesota
URL: http://hdl.handle.net/11299/173925
► Background: Chronic kidney disease (CKD) and cancer are major public health problems in the elderly population. In elderly cancer patients, little is known about chemotherapy-related…
(more)
▼ Background: Chronic kidney disease (CKD) and cancer are major public health problems in the elderly population. In elderly cancer patients, little is known about chemotherapy-related nephrotoxicity or patterns of CKD screening. The purpose of this dissertation was to evaluate the association between adjuvant chemotherapy (CHEMO) and risks of acute kidney injury (AKI) and CKD and rate of CKD screening in elderly women diagnosed with stages I-III breast cancer. Methods: The study was a 1:1 individually matched, retrospective cohort design using Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data. Matching was performed at the day of CHEMO initiation based on propensity score. The assembled matched cohorts were used in the analyses for all three objectives with different follow-up periods and statistical methods for each objective. HASH(0x307f974) Results: A total of 28,048 patients were included. CHEMO was associated with a 2.7-fold increased risk of AKI within 6 months after initiation (HR 2.7, 95% CI 1.8-4.1). To find a possible explanation to this association, the distribution of other diseases coded on hospital claims for AKI was examined and showed that septicemia occurred in 40% of CHEMO treated patients with AKI and in only 17% of untreated patients with AKI. No significant association was found between CHEMO and risk of CKD in the maximum 18 years follow-up (HR 1.00, 95% CI 0.93-1.07). The rate of CKD screening after treatment completion was low regardless of CHEMO status. HASH(0x2faf9d4) Conclusion: CHEMO is associated with increased risk of AKI. This association may be partially explained by septicemia caused by infection/neutropenia due to use of myelosuppressive chemotherapeutic agents, which highlights the importance of preventing serious complications of CHEMO in preventing AKI. The finding of no association between CHEMO and risk of CKD may not suggest a late nephrotoxic effect of chemotherapeutic agents commonly used to treat breast cancer in the adjuvant setting, or provide evidence to recommend a clinical practice guideline for CKD screening specifically in elderly breast cancer patients treated with CHEMO. Future studies of CKD as a late effect of cancer treatment for other solid tumors commonly treated with known or potential nephrotoxic agents are warranted.
Subjects/Keywords: Acute kidney injury; Breast cancer; Chemotherapy; Chronic kidney disease; CKD screening; Nephrotoxicity
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Manager
APA (6th Edition):
Li, S. (2013). Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/173925
Chicago Manual of Style (16th Edition):
Li, Shuling. “Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.” 2013. Doctoral Dissertation, University of Minnesota. Accessed February 27, 2021.
http://hdl.handle.net/11299/173925.
MLA Handbook (7th Edition):
Li, Shuling. “Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.” 2013. Web. 27 Feb 2021.
Vancouver:
Li S. Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. [Internet] [Doctoral dissertation]. University of Minnesota; 2013. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11299/173925.
Council of Science Editors:
Li S. Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. [Doctoral Dissertation]. University of Minnesota; 2013. Available from: http://hdl.handle.net/11299/173925
University of Ghana
9.
Kisseih-Kwao, V.P.
Psychological Health, Coping and Cultural Values among Haemodialysis Patients in a National Hospital in Ghana
.
Degree: 2020, University of Ghana
URL: http://ugspace.ug.edu.gh/handle/123456789/35881
► Coping with chronic health conditions has been attributed to numerous factors including spiritual/religious, collective and ritual behaviours of people with varied cultural backgrounds. The study…
(more)
▼ Coping with chronic health conditions has been attributed to numerous factors including spiritual/religious, collective and ritual behaviours of people with varied cultural backgrounds. The study examined psychological health, coping and cultural values among Ghanaians living with chronic kidney disease (CKD) and undergoing haemodialysis therapy. 125 respondents were recruited from the Dialysis Unit of the Korle-Bu Teaching Hospital in Accra, Ghana. The study adopted the sequential mixed method design which comprised a cross-sectional survey and a semi-structured interview. Tests administered assessed coping, religiosity/spirituality and psychological health. The results indicated a significant positive correlation between psychological symptoms (depression, anxiety and somatization) and religiosity/spirituality among haemodialysis patients. Cognitive/emotional debriefing of the Africultural Coping Systems Inventory is the most useful coping method for CKD patients. Furthermore, the results revealed that CKD patients who have spent four years or more on dialysis showed significantly fewer psychological symptoms than those who have been on the treatment for less than one year. Moreover, findings from the interviews showed that initial experiences of haemodialysis patients at the time of diagnosis included sadness/depression, uncertainty about the future, worries about how to deal with high cost of treatment, discomfort with restrictions and stigmatization.
Subjects/Keywords: Haemodialysis;
Ghana;
Chronic Kidney Disease (CKD);
Korle-Bu Teaching Hospital;
Chronic Health
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APA (6th Edition):
Kisseih-Kwao, V. P. (2020). Psychological Health, Coping and Cultural Values among Haemodialysis Patients in a National Hospital in Ghana
. (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/35881
Chicago Manual of Style (16th Edition):
Kisseih-Kwao, V P. “Psychological Health, Coping and Cultural Values among Haemodialysis Patients in a National Hospital in Ghana
.” 2020. Masters Thesis, University of Ghana. Accessed February 27, 2021.
http://ugspace.ug.edu.gh/handle/123456789/35881.
MLA Handbook (7th Edition):
Kisseih-Kwao, V P. “Psychological Health, Coping and Cultural Values among Haemodialysis Patients in a National Hospital in Ghana
.” 2020. Web. 27 Feb 2021.
Vancouver:
Kisseih-Kwao VP. Psychological Health, Coping and Cultural Values among Haemodialysis Patients in a National Hospital in Ghana
. [Internet] [Masters thesis]. University of Ghana; 2020. [cited 2021 Feb 27].
Available from: http://ugspace.ug.edu.gh/handle/123456789/35881.
Council of Science Editors:
Kisseih-Kwao VP. Psychological Health, Coping and Cultural Values among Haemodialysis Patients in a National Hospital in Ghana
. [Masters Thesis]. University of Ghana; 2020. Available from: http://ugspace.ug.edu.gh/handle/123456789/35881
University of Bradford
10.
Hadeiba, Tareg Hadi Ahmed.
The role of iron in oxidative stress accelerated endothelial dysfunction in chronic kidney disease.
Degree: PhD, 2015, University of Bradford
URL: http://hdl.handle.net/10454/14325
► Chronic kidney disease (CKD) is growing global public health problem affecting 1 in 10 adults in developed countries and recognised as an important risk factor…
(more)
▼ Chronic kidney disease (CKD) is growing global public health problem affecting 1 in 10 adults in developed countries and recognised as an important risk factor for cardiovascular disease (CVD) development. CVD is the main cause of death among CKD patients. Endothelial injury and dysfunction are critical steps in atherosclerosis, a major CVD. Oxidative stress (increased level of reactive oxygen species, ROS) has been associated with CVD development. Intravenous (IV) iron preparations are widely used in the management of CKD mediated anaemia, and have been associated with increased oxidative stress and cellular dysfunction. This study examined the effect of pharmacologically-relevant concentrations of IV Venofer (iron sucrose) or IV Ferinject (Ferric carboxymaltose, FCM) on primary human umbilical vein endothelial cell (HUVEC) activation/damage and on intracellular ROS generation as well as studying the potential mechanisms responsible. Data from TUNEL assay and Annexin V-FITC/PI staining showed that, IV FCM had no effect, but IV iron sucrose increased HUVEC apoptosis at 24hr. IV iron sucrose inhibited cell proliferation and reduced cell viability. Both compounds induced EC activation through sustained activation of p38 MAPK and up-regulation of ICAM-1 and VCAM-1. Additionally, the compounds induced significant increase in total ROS and superoxide anion production, which was attenuated by the anti-oxidant N-acetylcysteine (NAC). P38 MAPK showed up-regulation of pro-apoptotic protein Bax and down-regulation of antiapoptotic Bcl-2 protein in HUVEC treated with IV iron sucrose and p38 inhibition reversed these effects. In summary, these results suggest that IV iron sucrose causes more severe EC injury than IV FCM. However, both IV iron preparations induced intracellular ROS and superoxide anion generation in HUVEC leading to EC activation/dysfunction, providing a potential explanation for vascular damage in CKD patients.
Subjects/Keywords: 570; Endothelial cell; Intravenous iron preparations; Oxidative stress; Chronic kidney disease (CKD); Cardiovascular disease
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Export
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Manager
APA (6th Edition):
Hadeiba, T. H. A. (2015). The role of iron in oxidative stress accelerated endothelial dysfunction in chronic kidney disease. (Doctoral Dissertation). University of Bradford. Retrieved from http://hdl.handle.net/10454/14325
Chicago Manual of Style (16th Edition):
Hadeiba, Tareg Hadi Ahmed. “The role of iron in oxidative stress accelerated endothelial dysfunction in chronic kidney disease.” 2015. Doctoral Dissertation, University of Bradford. Accessed February 27, 2021.
http://hdl.handle.net/10454/14325.
MLA Handbook (7th Edition):
Hadeiba, Tareg Hadi Ahmed. “The role of iron in oxidative stress accelerated endothelial dysfunction in chronic kidney disease.” 2015. Web. 27 Feb 2021.
Vancouver:
Hadeiba THA. The role of iron in oxidative stress accelerated endothelial dysfunction in chronic kidney disease. [Internet] [Doctoral dissertation]. University of Bradford; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10454/14325.
Council of Science Editors:
Hadeiba THA. The role of iron in oxidative stress accelerated endothelial dysfunction in chronic kidney disease. [Doctoral Dissertation]. University of Bradford; 2015. Available from: http://hdl.handle.net/10454/14325
University of Illinois – Urbana-Champaign
11.
West, Mason James.
Assessing cognitive dysfunction in the hemodialysis population.
Degree: MS, Kinesiology, 2015, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/78372
► Patients with end stage renal diseases (ESRD) requiring hemodialysis treatment experience cognitive impairment due to a variety of risk factors; most of which stem from…
(more)
▼ Patients with end stage renal diseases (ESRD) requiring hemodialysis treatment experience cognitive impairment due to a variety of risk factors; most of which stem from chronic kidney disease (CKD) and the dialysis process itself. The purpose of this study was to assess changes in cognitive functioning in maintenance hemodialysis (MHD) patients during a standard hemodialysis (HD) session. MHD patients (n=12) were recruited from local dialysis clinics. Cognitive function was measured using a battery of tests from the CogState and Count Battle programs at 0, 1, and 3hrs into a standard HD treatment. In addition, quality of life and depression questionnaires, heart rate, blood pressure, relative blood volume (BV), hematocrit (HCT), and O2 saturation data was collected for comparison. Significant declines were seen in cognitive domains; specifically long term memory measures over the course of a dialysis session (p<0.05). A trend toward significance was seen in the cognitive measure of working memory and the cardiovascular measure of mean arterial blood pressure. The change in several hemodynamic variables (mean arterial blood pressure, hematocrit, and relative blood volume) were correlated with the change in several measures of cognitive function. In addition, questionnaires evaluating quality of life and depression were correlated with measures of cognitive function. These findings suggest that cognitive impairment in hemodialysis patients is most likely due to a variety of cerebrovascular problems caused by CKD and the hemodialysis process itself. Further studies are needed to determine if other domains are also affected and to pinpoint the primary mechanisms behind these cognitive issues.
Subjects/Keywords: cognition; cognitive impairment; hemodialysis (HD); chronic kidney disease; cognitive dysfunction; CogState; chronic kidney disease (CKD); maintenance hemodialysis (MHD)
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APA ·
Chicago ·
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Export
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APA (6th Edition):
West, M. J. (2015). Assessing cognitive dysfunction in the hemodialysis population. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/78372
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
West, Mason James. “Assessing cognitive dysfunction in the hemodialysis population.” 2015. Thesis, University of Illinois – Urbana-Champaign. Accessed February 27, 2021.
http://hdl.handle.net/2142/78372.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
West, Mason James. “Assessing cognitive dysfunction in the hemodialysis population.” 2015. Web. 27 Feb 2021.
Vancouver:
West MJ. Assessing cognitive dysfunction in the hemodialysis population. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2142/78372.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
West MJ. Assessing cognitive dysfunction in the hemodialysis population. [Thesis]. University of Illinois – Urbana-Champaign; 2015. Available from: http://hdl.handle.net/2142/78372
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
12.
Nenova-Nogalcheva, Anna / Ненова-Ногалчева, Анна.
Components of Oral Health in End-stage Chronic Kidney Disease Patients Undergoing Chronic Dialysis Treatment /// Компоненти на орално здраве при пациенти в терминален стадий на хронично бъбречно заболяване на хрониодиализно лечение.
Degree: 2018, Medical University of Varna
URL: http://repository.mu-varna.bg/handle/nls/415
► [EN] Chronic kidney disease (CKD) represents a global health issue with a rising prevalence - a clinical-laboratory syndrome, occurring as a result of progressive loss…
(more)
▼ [EN] Chronic kidney disease (CKD) represents a global health issue with a rising prevalence - a clinical-laboratory syndrome, occurring as a result of progressive loss of renal function and failure for months or years. Due to the underlying disease and long dialysis treatment, end-stage CKD patients are at a higher risk of developing typical oral manifestations. The aim of the dissertation was to research the manifestation, prevalence and type of oral health components in end-stage CKD patients, undergoing renal replacement therapy. Drawing upon latest clinical and laboratory methods, the study also aimed at developing a protocol for diagnosis and evaluation of the clinical condition of CKD patients that could be applied in clinical practices. The study targeted 70 patients diagnosed with end-stage CKD patients on haemodialysis treatment of different duration. A Diagnostic Card was designed to record patients’ medical history taken, oral status, gingival condition (PBI index), oral hygiene (Greene and Vermillion index), tongue coating and halitosis condition. Laboratory methods were applied to determine urea, creatinine, calcium and inorganic phosphorus levels in blood serum and in whole unstimulated saliva. Quantification of sIgA levels from salivary medium was performed using radial immunodiffusion (Mancini method). The protocol for diagnosis and evaluation of oral health was based on statistical analysis and the reliable test results obtained. ///////////// ///////////// [BG] Хроничното бъбречно заболяване (ХБЗ) е сред водещите по честота хронични заболявания, представлява клинико-лабораторен синдром, настъпващ вследствие на прогресивна загуба на бъбречната функция и увреждане в продължение на месеци или години. При пациентите в терминален стадий на ХБЗ вследствие на основното заболяване и продължителното хрониодиализно лечение се повишава риска от развитие на типични орални усложнения при болните. Целта на дисертационния труд е на основата на съвременни клинични и лабораторни методи да се проучи наличието, честотата и вида на някои от компонентите на оралното здраве при пациенти в терминален стадий на хронично бъбречно заболяване на заместително лечение и да се изведе приложим в амбулаторната практика алгоритъм за диагноза и оценка клиничното състояние при тези болни. В проучването са включени 70 пациенти с диагностициран терминален стадий на хронично бъбречно заболяване (ХБЗ) на хрониодиализно лечение с различна давност. За целите на изследването в специално създадена диагностична карта се отразяваха данните от анамнезата, орален статус, индекс за оценка на гингивалното възпаление (PBI), орално-хигиенен индекс по Green и Vermillion, степен на обложеност на език и измерване на лош дъх (халитоза). Използвахме лабораторни методи за определяне на показателите урея, креатинин, калций и неорганичен фосфор в кръвен серум и нестимулирана обща слюнка. Определянето на секреторен имуноглобулин А (sIgA) в нестимулирана обща слюнка беше извършено чрез радиална имунодифузия (метод на Mancini).
Subjects/Keywords: oral health; chronic kidney disease (CKD); end-stage CKD; hemodialysis; Орална и лицево-челюстна хирургия / Oral and Maxillofacial Surgery
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APA ·
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APA (6th Edition):
Nenova-Nogalcheva, Anna / Ненова-Ногалчева, . (2018). Components of Oral Health in End-stage Chronic Kidney Disease Patients Undergoing Chronic Dialysis Treatment /// Компоненти на орално здраве при пациенти в терминален стадий на хронично бъбречно заболяване на хрониодиализно лечение. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/415
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nenova-Nogalcheva, Anna / Ненова-Ногалчева, Анна. “Components of Oral Health in End-stage Chronic Kidney Disease Patients Undergoing Chronic Dialysis Treatment /// Компоненти на орално здраве при пациенти в терминален стадий на хронично бъбречно заболяване на хрониодиализно лечение.” 2018. Thesis, Medical University of Varna. Accessed February 27, 2021.
http://repository.mu-varna.bg/handle/nls/415.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nenova-Nogalcheva, Anna / Ненова-Ногалчева, Анна. “Components of Oral Health in End-stage Chronic Kidney Disease Patients Undergoing Chronic Dialysis Treatment /// Компоненти на орално здраве при пациенти в терминален стадий на хронично бъбречно заболяване на хрониодиализно лечение.” 2018. Web. 27 Feb 2021.
Vancouver:
Nenova-Nogalcheva, Anna / Ненова-Ногалчева . Components of Oral Health in End-stage Chronic Kidney Disease Patients Undergoing Chronic Dialysis Treatment /// Компоненти на орално здраве при пациенти в терминален стадий на хронично бъбречно заболяване на хрониодиализно лечение. [Internet] [Thesis]. Medical University of Varna; 2018. [cited 2021 Feb 27].
Available from: http://repository.mu-varna.bg/handle/nls/415.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nenova-Nogalcheva, Anna / Ненова-Ногалчева . Components of Oral Health in End-stage Chronic Kidney Disease Patients Undergoing Chronic Dialysis Treatment /// Компоненти на орално здраве при пациенти в терминален стадий на хронично бъбречно заболяване на хрониодиализно лечение. [Thesis]. Medical University of Varna; 2018. Available from: http://repository.mu-varna.bg/handle/nls/415
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
13.
Krige, Tammy.
Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study).
Degree: MMedSc, Pathology, 2017, Stellenbosch University
URL: http://hdl.handle.net/10019.1/102748
► ENGLISH ABSTRACT : Chronic kidney disease (CKD) is described as abnormal kidney function in which one third is lost over a period of 3 months…
(more)
▼ ENGLISH ABSTRACT :
Chronic kidney disease (
CKD) is described as abnormal
kidney function in which one third is
lost over a period of 3 months and is a global epidemic with a particularly concentrated
incidence within developing countries, such as Sub-Sahara Africa (SSA). Health facilities in
SSA are limited due to lack of funding and a dearth in
disease and medical knowledge. This
coupled with the high incidence of both communicable and non-communicable diseases
makes for an ideal environment for the implementation of Point-of-Care Testing (POCT),
defined as an analytical test that is performed near the patient, delivering results in real time
without the need for a conventional laboratory.
CKD POCT involves the measurement of
creatinine in capillary whole blood samples in order to determine the estimated glomerular
filtration rate (eGFR) of patients in order to stage their
CKD status from stage 1-6.
This study aimed to bridge the gap in knowledge with regard to cut-offs of creatinine levels
and eGFR values when screening a mixed ancestry populations. Currently there is only
documented and standardized cut-offs for Caucasian and African American populations. This
study looked at the African mixed ancestry population and acts as a starting point for
standardizing POCT cut-offs for other international mixed ancestry populations.
103 participants were recruited from the Bellville South community, Cape Town, South Africa. The
study was a comparative study that was designed to evaluate the Nova Statsensor® point of care
instrument for the measurement of creatinine for the detection of
CKD in adult mixed ancestry
subjects from the Bellville South Community in South Africa. Secondary objectives included (1)
the prevalence of
CKD based on the results of the instrument, and (2) the correlation between the
Nova Statsensor®, and the central laboratory creatinine values (IDMS traceable). Ancillary
objectives of the study were to evaluate the technical quality of POC testing for creatinine in a
community setting, as well as the evaluation of the cost implications when introducing this form of
POCT into a primary care setting.
The study found that the Nova Statsensor® in this study had a sensitivity of 66.7% and a
specificity of 100%, displaying excellent diagnostic accuracy. It was found that the device
displayed negative proportional bias which may lead to future
CKD patients being
misdiagnosed as healthy within screening programmes. The prevalence was found to be 2.9%
within this mixed ancestry population.
The device was user friendly and requires a small sample volume, however it is costly to
implement.
The laboratory evaluation study found that the Nova Statsensor® creatinine meter produced a
direct creatinine concentration comparison that was less than expected, possibly due to creatinine
levels depending on several factors which include muscle mass, obesity, gender, and age and
having a wide reference interval. Thus highlighting the importance of the use of the equations to
calculate eGFR…
Advisors/Committee Members: Erasmus, Rajiv, Rensburg, Megan, Stellenbosch University. Faculty of Medicine and Health Science. Dept. of Pathology. Division Chemical Pathology..
Subjects/Keywords: Blood – Diseases – Diagnosis; UCTD; Chronic kidney disease (CKD); Point-of-care testing (POCT); Creatine levels
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APA ·
Chicago ·
MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Krige, T. (2017). Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study). (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/102748
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Krige, Tammy. “Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study).” 2017. Thesis, Stellenbosch University. Accessed February 27, 2021.
http://hdl.handle.net/10019.1/102748.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Krige, Tammy. “Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study).” 2017. Web. 27 Feb 2021.
Vancouver:
Krige T. Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study). [Internet] [Thesis]. Stellenbosch University; 2017. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10019.1/102748.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Krige T. Screening for Chronic Kidney Disease (CKD) in a high risk population using a Point of Care Instrument for creatinine measurement: A community based study (The Bellville South Africa Study). [Thesis]. Stellenbosch University; 2017. Available from: http://hdl.handle.net/10019.1/102748
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
14.
Todorova, Teodora / Тодорова, Теодора.
Patient-Supporting Role in Nursing Care of Haemodialysis Patients. Medical and Social Aspects /// Подкрепящата роля на медицинската сестра за пациенти на хемодиализа (медико-социални аспекти).
Degree: 2018, Medical University of Varna
URL: http://repository.mu-varna.bg/handle/nls/493
► In recent decades the proportion of people with chronic illnesses has increased significantly worldwide. The increasing number of patients with end-stage renal disease requires qualified,…
(more)
▼ In recent decades the proportion of people with chronic illnesses has increased significantly worldwide. The increasing number of patients with end-stage renal disease requires qualified, long-term and complex nursing care. This thesis explores nursing care for patients on haemodialysis. Aim of the thesis is to investigate how the supporting role of the nurse in haemodialysis patients can reduce the complications during the dialysis procedure, increase the quality of life and the social activity of dialysis patients. /// [BG] Непрекъснатото увеличаване на новите болни с хронично бъбречно заболяване и на общо лекуваните с диализни методи е тенденция, наблюдавана в целия свят, като се повишава възрастовата граница. Това изисква квалифицирана, дългосрочна и комплексна сестринска грижа. Настоящата работа изследва сестринските грижи за пациенти на хемодиализа. Цел на дисертационния труд е да се проучи по какъв начин подкрепящата роля на медицинската сестра при пациенти на хемодиализно лечение може да осигури намаляване на усложненията по време на диализната процедура, повишаване качеството на живот и социалната активност на диализно болните.
Subjects/Keywords: chronic kidney disease (CKD) patients; haemodialysis patients; nursing care; Здравни грижи / Auxiliary health care, Nursing
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APA (6th Edition):
Todorova, Teodora / Тодорова, . (2018). Patient-Supporting Role in Nursing Care of Haemodialysis Patients. Medical and Social Aspects /// Подкрепящата роля на медицинската сестра за пациенти на хемодиализа (медико-социални аспекти). (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/493
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Todorova, Teodora / Тодорова, Теодора. “Patient-Supporting Role in Nursing Care of Haemodialysis Patients. Medical and Social Aspects /// Подкрепящата роля на медицинската сестра за пациенти на хемодиализа (медико-социални аспекти).” 2018. Thesis, Medical University of Varna. Accessed February 27, 2021.
http://repository.mu-varna.bg/handle/nls/493.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Todorova, Teodora / Тодорова, Теодора. “Patient-Supporting Role in Nursing Care of Haemodialysis Patients. Medical and Social Aspects /// Подкрепящата роля на медицинската сестра за пациенти на хемодиализа (медико-социални аспекти).” 2018. Web. 27 Feb 2021.
Vancouver:
Todorova, Teodora / Тодорова . Patient-Supporting Role in Nursing Care of Haemodialysis Patients. Medical and Social Aspects /// Подкрепящата роля на медицинската сестра за пациенти на хемодиализа (медико-социални аспекти). [Internet] [Thesis]. Medical University of Varna; 2018. [cited 2021 Feb 27].
Available from: http://repository.mu-varna.bg/handle/nls/493.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Todorova, Teodora / Тодорова . Patient-Supporting Role in Nursing Care of Haemodialysis Patients. Medical and Social Aspects /// Подкрепящата роля на медицинската сестра за пациенти на хемодиализа (медико-социални аспекти). [Thesis]. Medical University of Varna; 2018. Available from: http://repository.mu-varna.bg/handle/nls/493
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Ghana
15.
Acquaye, K.S.
Common Mental Disorders among Chronic Kidney Disease Out-Patients at Korle Bu Teaching Hospital
.
Degree: 2019, University of Ghana
URL: http://ugspace.ug.edu.gh/handle/123456789/33362
► Background: The association between chronic conditions such as Chronic Kidney Disease (CKD), and common mental disorders (CMD) or psychological distress has been well established in…
(more)
▼ Background: The association between chronic conditions such as Chronic Kidney Disease (CKD), and common mental disorders (CMD) or psychological distress has been well established in studies all over the world. This is however expected to be moderated given the presence of social support both from literature and practice.
General Objective: The study aimed at determining the prevalence of CMD, identifying factors associated with increased levels of psychological distress, and determining the role of perceived social support in CKD outpatients at the Korle Bu Teaching Hospital.
Methods: The design of the study was cross-sectional and employed quantitative data and statistical methods. The study site was the Korle-Bu Teaching Hospital, specifically the out-patient department and the renal unit of the medical block. A sample of 349 CKD outpatients, upon giving consent, was consecutively recruited into the study in June, 2019. The Kessler psychological distress scale (K10) and the Multidimensional Scale for Perceived Social Support scale were used to assess participants, including socio-demographic information and clinical data.
Results: Using the Kessler (K10) scale, the prevalence of CMD is 67.91%. Again, it is expected that 25% of all patients seen within primary care will score above 20 on the K10, signifying presence of CMD. The proportion of respondents scoring 20 and over from the current study is far greater than this proposed proportion (z= 19.28, p<0.0001). The main predictors of CMD among CKD were Estimated Glomerular Filtrate Rate (eGFR) categories and whether or not an individual was on dialysis, with increased odds of CMD with respect to eGFR decline [Adjusted Odds Ratio = 0.998 (95% CI: 0.980 , 1.016), p< 0.01)] and CMD being more prevalent among patients on dialysis [Adjusted OR = 3.82 (95% CI: 1.29 , 11.32), p= 0.016)].
Discussion: There was a high prevalence of CMD among CKD outpatients. CMD or psychological distress, also declined with decrease in renal function. For outpatients on dialysis, dialysis was a major source of psychological distress. Perceived social support did not significantly affect the relationship between either renal function or dialysis status and psychological distress.
Conclusion: CKD outpatients continue to be at an increased risk of major psychological ill-health as their kidney function further deteriorates. Further studies need to be done to explore issues concerning adjustment and resilience, in addition to the external social support that has been discussed as important in chronic disease management.
Subjects/Keywords: Mental Disorders;
Mental Health;
Chronic Kidney Disease (CKD);
Korle Bu Teaching Hospital
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APA (6th Edition):
Acquaye, K. S. (2019). Common Mental Disorders among Chronic Kidney Disease Out-Patients at Korle Bu Teaching Hospital
. (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/33362
Chicago Manual of Style (16th Edition):
Acquaye, K S. “Common Mental Disorders among Chronic Kidney Disease Out-Patients at Korle Bu Teaching Hospital
.” 2019. Masters Thesis, University of Ghana. Accessed February 27, 2021.
http://ugspace.ug.edu.gh/handle/123456789/33362.
MLA Handbook (7th Edition):
Acquaye, K S. “Common Mental Disorders among Chronic Kidney Disease Out-Patients at Korle Bu Teaching Hospital
.” 2019. Web. 27 Feb 2021.
Vancouver:
Acquaye KS. Common Mental Disorders among Chronic Kidney Disease Out-Patients at Korle Bu Teaching Hospital
. [Internet] [Masters thesis]. University of Ghana; 2019. [cited 2021 Feb 27].
Available from: http://ugspace.ug.edu.gh/handle/123456789/33362.
Council of Science Editors:
Acquaye KS. Common Mental Disorders among Chronic Kidney Disease Out-Patients at Korle Bu Teaching Hospital
. [Masters Thesis]. University of Ghana; 2019. Available from: http://ugspace.ug.edu.gh/handle/123456789/33362
University of Colorado
16.
Cureton, Andrew C.
Bone Morphology and Mechanical Properties in Murine Models of Chronic Kidney Disease.
Degree: MS, Mechanical Engineering, 2013, University of Colorado
URL: https://scholar.colorado.edu/mcen_gradetds/70
► The aim of this thesis is to investigate the changes in the bone tissue of mice that occur as a result of Chronic Kidney…
(more)
▼ The aim of this thesis is to investigate the changes in the bone tissue of mice that occur as a result of
Chronic Kidney Disease (
CKD). Due to the disruptions in mineral homeostasis and metabolism that result from loss of renal function, individuals with
CKD are at a higher risk of bone fracture. In order to study the relationship between
CKD and bone responses two surgical models of
CKD are used herein: uninephrectomy (UNx) and 5/6 nephrectomy (5/6Nx). In general, surgically induced
CKD was accompanied with a decrease in bone quality as measured by &muCT morphological analysis, mechanical testing, and quantitative histomorphometry. In male C57BL/6 mice aged 4 months, trabecular number (Tb.N) decreased and trabecular spacing (Tb.Sp) increased 8 weeks after UNx (p > 0.10), however no statistically significant changes in bone strength or microarchitecture were observed after UNx. Eight weeks after 5/6Nx, a model of moderate to severe
CKD, male C57BL/6 and FVB mice showed significant decrease in bone mineral density and cortical thickness, although no changes in mechanical properties were observed. Overall, these changes were shown to be compartment and site-specific and reveal that the effects of
CKD on bone tissue are complex and variable. Further investigation of the time course of the diseased state as well as dietary phosphate loads must be considered when researching bone effects of
CKD in murine models.
Advisors/Committee Members: Virginia L. Ferguson, Wei Tan, Karen King.
Subjects/Keywords: Bone; Chronic Kidney Disease; CKD; Mice; Biomedical Engineering and Bioengineering; Mechanical Engineering
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APA (6th Edition):
Cureton, A. C. (2013). Bone Morphology and Mechanical Properties in Murine Models of Chronic Kidney Disease. (Masters Thesis). University of Colorado. Retrieved from https://scholar.colorado.edu/mcen_gradetds/70
Chicago Manual of Style (16th Edition):
Cureton, Andrew C. “Bone Morphology and Mechanical Properties in Murine Models of Chronic Kidney Disease.” 2013. Masters Thesis, University of Colorado. Accessed February 27, 2021.
https://scholar.colorado.edu/mcen_gradetds/70.
MLA Handbook (7th Edition):
Cureton, Andrew C. “Bone Morphology and Mechanical Properties in Murine Models of Chronic Kidney Disease.” 2013. Web. 27 Feb 2021.
Vancouver:
Cureton AC. Bone Morphology and Mechanical Properties in Murine Models of Chronic Kidney Disease. [Internet] [Masters thesis]. University of Colorado; 2013. [cited 2021 Feb 27].
Available from: https://scholar.colorado.edu/mcen_gradetds/70.
Council of Science Editors:
Cureton AC. Bone Morphology and Mechanical Properties in Murine Models of Chronic Kidney Disease. [Masters Thesis]. University of Colorado; 2013. Available from: https://scholar.colorado.edu/mcen_gradetds/70
University of Edinburgh
17.
Finnie, Sarah Louise.
Investigating Ass1 and its role in renal fibrosis.
Degree: PhD, 2020, University of Edinburgh
URL: http://hdl.handle.net/1842/36957
► Background: The incidence of chronic kidney disease (CKD) is rising and is the 12th most common cause of death worldwide. Currently, the only available treatments…
(more)
▼ Background: The incidence of chronic kidney disease (CKD) is rising and is the 12th most common cause of death worldwide. Currently, the only available treatments are renal replacement therapy and transplantation, both of which are significantly costly for the NHS. Therefore there is an unmet clinical need for new therapies which can tackle the manifestation of renal disease processes and progression to CKD. The pathophysiological process common to all CKDs, regardless of the initiating aetiology, is tubulointerstitial fibrosis (TIF). TIF leads to scarring of the kidney and results in loss of renal function and eventual end-stage renal disease. TIF is driven by a number of pathophysiological processes taking place in several cell types including the proximal tubule. The proximal tubule (PT) is sensitive to injury and in a damaged state has attracted attention as a driver of fibrotic disease due to de-differentiation and pro-inflammatory/ pro-fibrotic signalling. Argininosuccinate synthetase (ASS1), a ratelimiting urea cycle enzyme, is highly expressed in the PT and has been reported to be downregulated in human CKD. Furthermore, urea cycle metabolites such as citrulline have been reported to be dysregulated in renal disease. Hypothesis: Loss of tubular ASS1 expression is critical in the induction of renal fibrosis. Results: Renal Ass1 expression was assessed and compared to sham operated animals in ischaemia-reperfusion injury (IRI), subtotal nephrectomy (STNx), obstructive (UUO) and reversible obstructive (rUUO) murine models. Ass1 expression was significantly downregulated in all models of injury. Ass1 loss occurred at early time points and preceded the manifestation of fibrosis. Single cell RNA-seq of the reversible UUO model was adopted to assess Ass1 expression during the progression and reversal of fibrosis. After obstruction, Ass1 was significantly depleted in fibrotic tubular epithelial cells. Upon reversal of fibrosis, Ass1 expression levels almost returned to normal. ASS1 is highly expressed in human proximal tubular epithelial cells (RPTEC/TERT1). To determine the consequences of ASS1 depletion, ASS1 was knocked-down in RPTECs. This induced upregulation of pro-fibrotic genes and downregulation of cell-cell contact genes. In RPTECs, ASS1 transcription was unaffected by pro-fibrotic, TGFβ. However, ASS1 transcription was significantly reduced in a dose-dependent manner following TNFα treatment and hypoxia. In order to further interrogate the function of Ass1 in tubular epithelial cells in vivo, Ass1 was conditionally knocked out in renal tubular cells specifically using the Pax8 CreERT2 floxed Ass1 transgenic mouse. The effect of Pax8 Cre x Ass1 flox/wt heterozygous knock-out was assessed to explore if partial loss of Ass1 exerted a haploinsufficiency effect. Heterozygous mice did not demonstrate any renal phenotype distinct from controls. A small cohort of Pax8 Cre x Ass1 flox/flox mice homozygous were assessed to interrogate the effects of full knock out of Ass1 in the kidney. Pax8Cre x Ass1 flox/flox…
Subjects/Keywords: chronic kidney disease; CKD; tubulointerstitial fibrosis; TIF; Argininosuccinate synthetase; ASS1; renal fibrosis; RPTEC/TERT1
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APA ·
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APA (6th Edition):
Finnie, S. L. (2020). Investigating Ass1 and its role in renal fibrosis. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/36957
Chicago Manual of Style (16th Edition):
Finnie, Sarah Louise. “Investigating Ass1 and its role in renal fibrosis.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed February 27, 2021.
http://hdl.handle.net/1842/36957.
MLA Handbook (7th Edition):
Finnie, Sarah Louise. “Investigating Ass1 and its role in renal fibrosis.” 2020. Web. 27 Feb 2021.
Vancouver:
Finnie SL. Investigating Ass1 and its role in renal fibrosis. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1842/36957.
Council of Science Editors:
Finnie SL. Investigating Ass1 and its role in renal fibrosis. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: http://hdl.handle.net/1842/36957
University of Edinburgh
18.
Finnie, Sarah Louise.
Investigating Ass1 and its role in renal fibrosis.
Degree: PhD, 2020, University of Edinburgh
URL: https://doi.org/10.7488/era/258
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.802357
► Background: The incidence of chronic kidney disease (CKD) is rising and is the 12th most common cause of death worldwide. Currently, the only available treatments…
(more)
▼ Background: The incidence of chronic kidney disease (CKD) is rising and is the 12th most common cause of death worldwide. Currently, the only available treatments are renal replacement therapy and transplantation, both of which are significantly costly for the NHS. Therefore there is an unmet clinical need for new therapies which can tackle the manifestation of renal disease processes and progression to CKD. The pathophysiological process common to all CKDs, regardless of the initiating aetiology, is tubulointerstitial fibrosis (TIF). TIF leads to scarring of the kidney and results in loss of renal function and eventual end-stage renal disease. TIF is driven by a number of pathophysiological processes taking place in several cell types including the proximal tubule. The proximal tubule (PT) is sensitive to injury and in a damaged state has attracted attention as a driver of fibrotic disease due to de-differentiation and pro-inflammatory/ pro-fibrotic signalling. Argininosuccinate synthetase (ASS1), a ratelimiting urea cycle enzyme, is highly expressed in the PT and has been reported to be downregulated in human CKD. Furthermore, urea cycle metabolites such as citrulline have been reported to be dysregulated in renal disease. Hypothesis: Loss of tubular ASS1 expression is critical in the induction of renal fibrosis. Results: Renal Ass1 expression was assessed and compared to sham operated animals in ischaemia-reperfusion injury (IRI), subtotal nephrectomy (STNx), obstructive (UUO) and reversible obstructive (rUUO) murine models. Ass1 expression was significantly downregulated in all models of injury. Ass1 loss occurred at early time points and preceded the manifestation of fibrosis. Single cell RNA-seq of the reversible UUO model was adopted to assess Ass1 expression during the progression and reversal of fibrosis. After obstruction, Ass1 was significantly depleted in fibrotic tubular epithelial cells. Upon reversal of fibrosis, Ass1 expression levels almost returned to normal. ASS1 is highly expressed in human proximal tubular epithelial cells (RPTEC/TERT1). To determine the consequences of ASS1 depletion, ASS1 was knocked-down in RPTECs. This induced upregulation of pro-fibrotic genes and downregulation of cell-cell contact genes. In RPTECs, ASS1 transcription was unaffected by pro-fibrotic, TGFβ. However, ASS1 transcription was significantly reduced in a dose-dependent manner following TNFα treatment and hypoxia. In order to further interrogate the function of Ass1 in tubular epithelial cells in vivo, Ass1 was conditionally knocked out in renal tubular cells specifically using the Pax8 CreERT2 floxed Ass1 transgenic mouse. The effect of Pax8 Cre x Ass1 flox/wt heterozygous knock-out was assessed to explore if partial loss of Ass1 exerted a haploinsufficiency effect. Heterozygous mice did not demonstrate any renal phenotype distinct from controls. A small cohort of Pax8 Cre x Ass1 flox/flox mice homozygous were assessed to interrogate the effects of full knock out of Ass1 in the kidney. Pax8Cre x Ass1 flox/flox…
Subjects/Keywords: chronic kidney disease; CKD; tubulointerstitial fibrosis; TIF; Argininosuccinate synthetase; ASS1; renal fibrosis; RPTEC/TERT1
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APA ·
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Export
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Manager
APA (6th Edition):
Finnie, S. L. (2020). Investigating Ass1 and its role in renal fibrosis. (Doctoral Dissertation). University of Edinburgh. Retrieved from https://doi.org/10.7488/era/258 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.802357
Chicago Manual of Style (16th Edition):
Finnie, Sarah Louise. “Investigating Ass1 and its role in renal fibrosis.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed February 27, 2021.
https://doi.org/10.7488/era/258 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.802357.
MLA Handbook (7th Edition):
Finnie, Sarah Louise. “Investigating Ass1 and its role in renal fibrosis.” 2020. Web. 27 Feb 2021.
Vancouver:
Finnie SL. Investigating Ass1 and its role in renal fibrosis. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Feb 27].
Available from: https://doi.org/10.7488/era/258 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.802357.
Council of Science Editors:
Finnie SL. Investigating Ass1 and its role in renal fibrosis. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: https://doi.org/10.7488/era/258 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.802357
University of Sydney
19.
Lopez-Vargas, Pamela.
Improving outcomes for people with chronic kidney disease through education
.
Degree: 2015, University of Sydney
URL: http://hdl.handle.net/2123/14769
► Chronic kidney disease (CKD) continues to increase worldwide. Professional organisations are committed to developing clinical practice guidelines to manage and prevent disease progression. People with…
(more)
▼ Chronic kidney disease (CKD) continues to increase worldwide. Professional organisations are committed to developing clinical practice guidelines to manage and prevent disease progression. People with diabetes and hypertension are at greatest risk of developing CKD, but other risk factors include smoking, obesity, family history of CKD and being Aboriginal/ Torres Strait Islander or other ethnic minority. In order to prevent disease progression and other complications such as heart attack or stroke, people with early stage CKD patients must actively participate in their health care treatment. This however, may be limited by lack of understanding and awareness of the disease. Educational interventions may facilitate learning and provide patients with the knowledge and skills to better manage their condition. This is a thesis by publication containing published and submitted work related to providing health education for patients with CKD to assist in self-management of their condition. The first chapter is a general introduction. Chapter two provides an overall summary of current clinical management, patient education and information needs and education strategies. Chapter three is a systematic review of international clinical practice guidelines that are used for the management, detection and prevention of CKD. Chapters four and five are based on an original qualitative study that identifies patients’ educational needs and their awareness about CKD, associated risk factors and comorbidities. Chapter six includes a systematic review of educational interventions for patients with CKD which were assessed using risk of bias tools. The final chapter provides an overall discussion of this work. The primary objective of this thesis was to expand on the current evidence base for the management of patients with early stage CKD, and provide guidance on the development and implementation of educational interventions to help delay CKD progression.
Subjects/Keywords: patient education;
chronic kidney disease;
education strategies;
clinical practice guidelines;
CKD risk factors and comorbidities
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APA (6th Edition):
Lopez-Vargas, P. (2015). Improving outcomes for people with chronic kidney disease through education
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/14769
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lopez-Vargas, Pamela. “Improving outcomes for people with chronic kidney disease through education
.” 2015. Thesis, University of Sydney. Accessed February 27, 2021.
http://hdl.handle.net/2123/14769.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lopez-Vargas, Pamela. “Improving outcomes for people with chronic kidney disease through education
.” 2015. Web. 27 Feb 2021.
Vancouver:
Lopez-Vargas P. Improving outcomes for people with chronic kidney disease through education
. [Internet] [Thesis]. University of Sydney; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2123/14769.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lopez-Vargas P. Improving outcomes for people with chronic kidney disease through education
. [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/14769
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
Teodorova, Iliana / Теодорова, Илиана.
Markers for Evaluation of the Activity and Progression of the Kidney Disease in Adult Patients with Chronic Glomerular Disorders /// Показатели за оценка на активността и прогресията на бъбречното заболяване при възрастни пациенти с хронични гломерулопатии.
Degree: 2017, Medical University of Varna
URL: http://repository.mu-varna.bg/handle/nls/328
► [EN] Proteinuria is an important marker for the diagnosis and monitoring of the activity of chronic glomerulopathies. It is associated with increased cardiovascular risk and…
(more)
▼ [EN] Proteinuria is an important marker for the diagnosis and monitoring of the activity of chronic glomerulopathies. It is associated with increased cardiovascular risk and the risk of progressive deterioration of the renal function. Modern science has a number of serum and urinary biomarkers that have not yet been widely used in nephrology. The subject of this thesis is an analysis of one of the leading reasons for chronic kidney disease (CKD) – the chronic glomerulopathy. The significance of the problem is determined by the fact that glomerulonephritis (GN) is the third leading cause for end-stage renal disease (ESRD) in the European population as well. In this study we set the objective to examine the predicting value of Upr/Uosm, Ualb/Uosm ratios for 24h proteinuria in patients with chronic glomerular disorders. We used a correlation analysis. The results are showing significant connections between the examined parameters - Upr/Uosm, Ualb/Uosm ratios in spot urine and 24h proteinuria, and the strongest link is between 24h proteinuria and Upr/Uosm ratio (r=0,517, p <0,001). Through the use of regression analysis we examined which and how precise the Upr/Uosm and Ualb/Uosm ratios could determine the amount of 24h proteinuria. This is the first of its kind clinical study in Bulgaria which uses Uosm as a reachable, trustworthy and valuable laboratory marker for evaluating the activity of the renal disease. For the first time it is established that Upr/Uosm and Ualb/Uosm ratios in spot urine could be an adequate and sufficient laboratory marker for the activity of primary and secondary glomerular disorders. ///////////////// ///////////////// [BG] Протеинурията е основен маркер за диагностика и проследяване активността на хроничните гломерулопатии. Тя се асоциира с повишен сърдечно-съдов риск и риск от прогресивно влошаване на бъбречната функция. Днес науката разполага с редица съвременни серумни и уринни биомаркери, които все още не са намерили широка употреба в нефрологичната практика. Направеният задълбочен анализ на уринните показатели показа, че отношенията Upr/Ucr и Ualb/Ucr в случайна порция урина могат да се използват като скринингови тестове при пациенти с ХГП. Сравнителното проучване на отношенията Upr/Uosm и Ualb/Uosm с утвърдените в практиката отношения Upr/Ucr и Ualb/Ucr показаха много добра съпоставимост, което предлага разширяване на спектъра от неинвазивни методи за проследяване активността и прогресията на ХГП. Резултатите показаха, че отношението Upr/Uosm е достоверен показател за продължително проследяване активността на бъбречното заболяване. Установено беше, че отношението Ualb/Uosm в случайна порция урина може да служи като чувствителен показател за регистриране тенденция към ремисия или настъпила ремисия на заболяването. Възможността отношението Upr/Uosm да бъде надежден предиктор за 24ч протеинурия, позволява да бъде преоценена необходимостта от количествено изследване на 24 часова белтъчна загуба. Използването на случайна порция урина е практически приложима проба с висока достоверност на…
Subjects/Keywords: chronic kidney disease (CKD); end-stage renal disease (ESRD); proteinuria; glomerulonephritis (GN); chronic glomerulopathy; urinary biomarkers; Неврохирургия / Neurosurgery
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APA (6th Edition):
Teodorova, Iliana / Теодорова, . (2017). Markers for Evaluation of the Activity and Progression of the Kidney Disease in Adult Patients with Chronic Glomerular Disorders /// Показатели за оценка на активността и прогресията на бъбречното заболяване при възрастни пациенти с хронични гломерулопатии. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/328
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Teodorova, Iliana / Теодорова, Илиана. “Markers for Evaluation of the Activity and Progression of the Kidney Disease in Adult Patients with Chronic Glomerular Disorders /// Показатели за оценка на активността и прогресията на бъбречното заболяване при възрастни пациенти с хронични гломерулопатии.” 2017. Thesis, Medical University of Varna. Accessed February 27, 2021.
http://repository.mu-varna.bg/handle/nls/328.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Teodorova, Iliana / Теодорова, Илиана. “Markers for Evaluation of the Activity and Progression of the Kidney Disease in Adult Patients with Chronic Glomerular Disorders /// Показатели за оценка на активността и прогресията на бъбречното заболяване при възрастни пациенти с хронични гломерулопатии.” 2017. Web. 27 Feb 2021.
Vancouver:
Teodorova, Iliana / Теодорова . Markers for Evaluation of the Activity and Progression of the Kidney Disease in Adult Patients with Chronic Glomerular Disorders /// Показатели за оценка на активността и прогресията на бъбречното заболяване при възрастни пациенти с хронични гломерулопатии. [Internet] [Thesis]. Medical University of Varna; 2017. [cited 2021 Feb 27].
Available from: http://repository.mu-varna.bg/handle/nls/328.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Teodorova, Iliana / Теодорова . Markers for Evaluation of the Activity and Progression of the Kidney Disease in Adult Patients with Chronic Glomerular Disorders /// Показатели за оценка на активността и прогресията на бъбречното заболяване при възрастни пациенти с хронични гломерулопатии. [Thesis]. Medical University of Varna; 2017. Available from: http://repository.mu-varna.bg/handle/nls/328
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Anna University
21.
Prasanna Devi S.
A study on improving certain pre transplantation decision
issues related to kidney and corneal transplantation
programs;.
Degree: 2013, Anna University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/13434
► Organ transplantation is the most preferred treatment modality for patients with end-stage organ disease. At present the supply of cadaver organs is so inadequate as…
(more)
▼ Organ transplantation is the most preferred
treatment modality for patients with end-stage organ disease. At
present the supply of cadaver organs is so inadequate as not to be
commensurate with need. In India, there are very few Organ
Procurement Organizations (OPO s) to supervise the activities of
organ donation and transplantation at a national level. Our country
seems to lack an active organ sharing network both at the state and
national level. The present study focuses on integrating
applications of systems and industrial engineering techniques to
increase the number of organ transplants in India, particularly at
the state level. i.e. in Tamil Nadu (Case study region). The
different issues considered for the study include: A retrospective
study of the renal failure patients was done to understand the
association of the lifestyle factors and the Chronic Kidney Disease
(CKD); A system dynamics simulation study was carried out to study
the various dynamics involved in organ transplants, in particular
corneal transplants.; A website has been designed, developed and
launched to promote organ donation awareness among the community,
which is most critical to increase the number of transplants in our
country; Networking of approved Transplant Centres (TC s) and
optimal location for setting up of OPO s were proposed using
facility location P-median model. This will facilitate optimal
distribution and allocation of deceased organs to recipients in the
waiting list without organ wastage due to lapse of the Cold
Ischemic Time (CIT); A simulation study was carried out on the
world renowned different transplantation programmes and compared
with the Cadaver Transplant Program (CTP) which is the only
legalized transplantation program in India. The evaluation has been
done to find out the waiting time of different blood group patients
and the best serving programme for a particular blood type patient
is thus recommended to minimize the waiting time of the patient.
newline
Appendices 1 to 7; pp.154-187
Advisors/Committee Members: Suryaprakasa Rao, K..
Subjects/Keywords: Pre-transplantation; kidney; corneal transplantation;
Chronic Kidney Disease (CKD); Tamil Nadu; Transplant Centres; Cold
Ischemic Time; Cold Ischemic Time; India
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APA ·
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APA (6th Edition):
S, P. D. (2013). A study on improving certain pre transplantation decision
issues related to kidney and corneal transplantation
programs;. (Thesis). Anna University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13434
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
S, Prasanna Devi. “A study on improving certain pre transplantation decision
issues related to kidney and corneal transplantation
programs;.” 2013. Thesis, Anna University. Accessed February 27, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/13434.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
S, Prasanna Devi. “A study on improving certain pre transplantation decision
issues related to kidney and corneal transplantation
programs;.” 2013. Web. 27 Feb 2021.
Vancouver:
S PD. A study on improving certain pre transplantation decision
issues related to kidney and corneal transplantation
programs;. [Internet] [Thesis]. Anna University; 2013. [cited 2021 Feb 27].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13434.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
S PD. A study on improving certain pre transplantation decision
issues related to kidney and corneal transplantation
programs;. [Thesis]. Anna University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13434
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
NSYSU
22.
Wu, Chien-yi.
Relationship of Urinary Neutrophil Gelatinase-associated Lipocalin and Uromodulin with Chronic Kidney Disease.
Degree: Master, Biological Sciences, 2013, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825113-002013
► The link between neutrophil gelatinase-associated lipocalin ( NGAL) and uromodulin (UMOD) with chronic kidney disease (CKD) has attracted much interest in the medical literature. Several…
(more)
▼ The link between neutrophil gelatinase-associated lipocalin ( NGAL) and uromodulin (UMOD) with
chronic kidney disease (
CKD) has attracted much interest in the medical literature. Several investigations showed UMOD had active role in
CKD progression. A total of 77 Taiwanese patients with stable
disease activity selected from the cohort that attended our renal and rheumatology outpatient department were enrolled. Their demographic data, laboratory tests including urinary microalbumiuria excretion, serum creatinine, serum uric acid, eGFR, and urinary creatinine, NGAL and UMOD level were measured. The results showed that urinary NGAL excretion correlated negatively with eGFR, and urinary UMOD excretion correlated positively with eGFR. Gender and urinary NGAL excretion did not differ between the
CKD and non-
CKD groups. However, age (
CKD group: 64.5± 12.13 years, Non-
CKD group: 47.03±11.87 years, p< 0.0001) and serum uric acid (
CKD group: 8.12 ± 2.32 mg/dl, Non-
CKD group: 6.39 ± 1.72 mg/dl, p<0.001) were significantly different between groups. Using multivariate analysis, patients with
CKD had lower urinary UMOD excretion (Odds Ratio 0.82, 95% confidence interval: 0.69-0.98, p=0.029), and were more likely to be older (p< 0.01). Urinary NGAL excretion, urinary albumin excretion, status of diabetic mellitus, hypertension, gout were not associated with status of
CKD. Our study indicated that UMOD might play a role in the development of
CKD. Urinary NGAL excretion was not associated with gout or
CKD. Further studies with animal model of gout and
CKD are mandatory to establish fundamental pathological mechanism and explore the clinical implications
Advisors/Committee Members: Chung-Lung Cho (chair), Feng-Rong Chuang (chair), Hsueh-Wen Chang (committee member).
Subjects/Keywords: Chronic Kidney Disease (CKD); Gout; Estimated glomerulus filtration rate (eGFR); Neutrophil Gelatinase-associated Lipocalin (NGAL); Uromodulin (UMOD)
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APA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wu, C. (2013). Relationship of Urinary Neutrophil Gelatinase-associated Lipocalin and Uromodulin with Chronic Kidney Disease. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825113-002013
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wu, Chien-yi. “Relationship of Urinary Neutrophil Gelatinase-associated Lipocalin and Uromodulin with Chronic Kidney Disease.” 2013. Thesis, NSYSU. Accessed February 27, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825113-002013.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wu, Chien-yi. “Relationship of Urinary Neutrophil Gelatinase-associated Lipocalin and Uromodulin with Chronic Kidney Disease.” 2013. Web. 27 Feb 2021.
Vancouver:
Wu C. Relationship of Urinary Neutrophil Gelatinase-associated Lipocalin and Uromodulin with Chronic Kidney Disease. [Internet] [Thesis]. NSYSU; 2013. [cited 2021 Feb 27].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825113-002013.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wu C. Relationship of Urinary Neutrophil Gelatinase-associated Lipocalin and Uromodulin with Chronic Kidney Disease. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0825113-002013
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
23.
Hamano, Hirofumi.
The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease : 尿毒素物質インドキシル硫酸はヘプシジン制御を介して慢性腎臓病における鉄代謝を障害する.
Degree: 博士（医学）, 2017, Tokushima University / 徳島大学
URL: http://repo.lib.tokushima-u.ac.jp/110922
Subjects/Keywords: Indoxyl sulfate; chronic kidney disease; CKD; hepcidin; iron
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APA ·
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APA (6th Edition):
Hamano, H. (2017). The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease : 尿毒素物質インドキシル硫酸はヘプシジン制御を介して慢性腎臓病における鉄代謝を障害する. (Thesis). Tokushima University / 徳島大学. Retrieved from http://repo.lib.tokushima-u.ac.jp/110922
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hamano, Hirofumi. “The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease : 尿毒素物質インドキシル硫酸はヘプシジン制御を介して慢性腎臓病における鉄代謝を障害する.” 2017. Thesis, Tokushima University / 徳島大学. Accessed February 27, 2021.
http://repo.lib.tokushima-u.ac.jp/110922.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hamano, Hirofumi. “The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease : 尿毒素物質インドキシル硫酸はヘプシジン制御を介して慢性腎臓病における鉄代謝を障害する.” 2017. Web. 27 Feb 2021.
Vancouver:
Hamano H. The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease : 尿毒素物質インドキシル硫酸はヘプシジン制御を介して慢性腎臓病における鉄代謝を障害する. [Internet] [Thesis]. Tokushima University / 徳島大学; 2017. [cited 2021 Feb 27].
Available from: http://repo.lib.tokushima-u.ac.jp/110922.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hamano H. The uremic toxin indoxyl sulfate interferes with iron metabolism by regulating hepcidin in chronic kidney disease : 尿毒素物質インドキシル硫酸はヘプシジン制御を介して慢性腎臓病における鉄代謝を障害する. [Thesis]. Tokushima University / 徳島大学; 2017. Available from: http://repo.lib.tokushima-u.ac.jp/110922
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Freie Universität Berlin
24.
Filip, Szymon.
Identifizierung von Protein-Biomarkern für die Entwicklung einer chronischen
Nierenerkrankung mit modernsten Proteomik-Ansätzen.
Degree: 2016, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-14451
► Proteine sind verantwortlich für die wichtigsten Funktionen im Organismus, der Homöostase und des Krankheitszustandes. Großangelegte Proteomstudien sind unter anderem mit dem Ziel durchgeführt worden, neue…
(more)
▼ Proteine sind verantwortlich für die wichtigsten Funktionen im Organismus, der
Homöostase und des Krankheitszustandes. Großangelegte Proteomstudien sind
unter anderem mit dem Ziel durchgeführt worden, neue Protein-Biomarkern
komplexer Erkrankungen wie beispielsweise der chronischen Nierenerkrankungen
(
CKD) zu identifizieren. Gegenwärtige werden Biomarker zur Frühdiagnostik und
Progression der
CKD intensiv gesucht Das Ziel der vorliegenden Dissertation
ist es daher einen Beitrag zur Identifizierung von proteomischen Änderungen im
Rahmen der
CKD zu leisten und dadurch neue Biomarker zu beschreiben zu könen.
Der erste Teil der Dissertation konzentriert sich auf die Identifizierung von
proteomischen Veränderungen im Plasma von
CKD-Patienten. Es wurde das Plasma-
Proteom von
CKD-Patienten in
CKD Stadium 2-4 und 5 mit oder ohne Hämodialyse
mittels Flüssigkeitschromatographie mit Tandem-Massenspektrometrie (LC-MS/MS)
und enzymgekoppelter Immunadsorptionstest (ELISA) untersucht. Pathway-Analysen
bestätigten Modifikation der bekannten Stoffwechselprozesse, die in der
CKD-
Pathophysiologie beteiligt sind. Dazu gehört die Deregulierung der Fibrin-
Gerinnselbildung und die Aktivierung des Komplements. Außerdem konnte
festgestellt werden, dass das Niveau von Komplementfaktor D, Lysozym C und
leucin-reichen alpha-2-Glykoprotein mit der
CKD-Progression erhöht wird. Der
zweite Teil der Dissertation konzentriert sich auf die Optimierung des
Protokolls zur Identifizierung von
CKD-Progressionsbiomarkern im Urin. In
dieser Studie verglichen wir die Reproduzierbarkeit und Effizienz der
Abreicherung von hochkonzentierten Proteine mit verschiedenen Methoden unter
Verwendung der Urinproben von
CKD-Patienten und Kontrollen. Abnahme der Menge
von Albumin und anderen Analyten nachfolgend der Probenbehandlung wurde
beobachtet. Allerdings bliebt die Anzahl der Protein-Identifikationen
konstant. Der dritte Teil der vorliegenden Arbeit fokussiert sich auf die
Identifizierung von
CKD-Biomarkern in Gewebeproben unter Verwendung der
Technik des „Matrix-unterstützter Laser-Desorption/Ionisation-Bildgebung“
(MALDI-MSI). Frisches gefrorenes Nierengewebe von Patienten und Kontrollen
wurden analysiert um molekulare Signaturen von primären Glomerulonephritis zu
erkennen. Mittels MALDI-MSI konnten molekulare Signaturen generiert werden,
die zwischen der normalen Niere und idiopathische Glomerulonephritis
unterschieden, mit Massensignalen, die potenzielle Indikatoren für die
CKD-
Entwicklung darstellen. Ein Massensignal bei 4048 (m/z) wurde als ein
α-1-Antitrypsin (A1AT) Peptid identifiziert und es wurde durch
Immunhistochemie gezeigt, dass das Protein in den Podozyten innerhalb
sklerotischer Glomerulie lokalisiert ist. Zusätzlich führte die Korrelation
von MALDI-MSI Ergebnissen mit Urin- Proteomik zur Identifizierung eines A1AT-
Peptids, das bei
CKD-Patienten hochreguliert war. Jede dieser Studien bringt
neue Erkenntnisse in Bezug auf die
CKD-Progression. Diese Ergebnisse werden
die Aufklärung der Progressionsmechanismus der Krankheit erlauben und einen…
Advisors/Committee Members: [email protected] (contact), m (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: chronic kidney disease; CKD; proteomics; mass spectrometry; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Filip, S. (2016). Identifizierung von Protein-Biomarkern für die Entwicklung einer chronischen
Nierenerkrankung mit modernsten Proteomik-Ansätzen. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14451
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Filip, Szymon. “Identifizierung von Protein-Biomarkern für die Entwicklung einer chronischen
Nierenerkrankung mit modernsten Proteomik-Ansätzen.” 2016. Thesis, Freie Universität Berlin. Accessed February 27, 2021.
http://dx.doi.org/10.17169/refubium-14451.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Filip, Szymon. “Identifizierung von Protein-Biomarkern für die Entwicklung einer chronischen
Nierenerkrankung mit modernsten Proteomik-Ansätzen.” 2016. Web. 27 Feb 2021.
Vancouver:
Filip S. Identifizierung von Protein-Biomarkern für die Entwicklung einer chronischen
Nierenerkrankung mit modernsten Proteomik-Ansätzen. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2021 Feb 27].
Available from: http://dx.doi.org/10.17169/refubium-14451.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Filip S. Identifizierung von Protein-Biomarkern für die Entwicklung einer chronischen
Nierenerkrankung mit modernsten Proteomik-Ansätzen. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-14451
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
25.
Eddington, Helen.
Improving the outcomes of patients with chronic kidney disease-mineral bone disorder.
Degree: PhD, 2013, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/improving-the-outcomes-of-patients-with-chronic-kidney-disease –
mineral-bone-disorder(0c72d2af-4523-43c4-a1f9-95ecb304e5ac).html
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566606
► Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a systemic disorder which includes abnormal bone chemistry, vascular or soft tissue calcification, and abnormal bone formation. Many…
(more)
▼ Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a systemic disorder which includes abnormal bone chemistry, vascular or soft tissue calcification, and abnormal bone formation. Many of the parameters of CKD-MBD have been associated with an increased mortality risk in renal patients. There were three main facets to this research project. The first aim of this research was to perform two different studies using the Chronic Renal Insufficiency Standards Implementation Study (CRISIS) data. This prospective epidemiological study is designed to identify factors associated with renal progression and survival in the pre-dialysis CKD population. We have shown that for each 0.323mmol/L (1mg/dL) increase in serum phosphate there was a significant stepwise increased risk of death. (HR1.3 (1.1, 1.5) P=0.01). The association of baseline phenotypic data against vascular stiffness measurements was also investigated. Augmentation index measured at the radial artery was associated with a raised systolic blood pressure but no association with biochemical abnormalities was found.We hypothesised that the phosphate effect on survival was related to the effects within the CKD-MBD spectrum and therefore control of secondary hyperparathyroidism would improve bone and cardiovascular parameters. Therefore for the second part of this research we performed a randomised controlled trial to examine the effects of cinacalcet with standard therapy compared to standard therapy alone on bone and cardiovascular parameters in haemodialysis patients with uncontrolled hyperparathyroidism. The change of biochemical parameters and cardiovascular markers were also further explored in secondary analyses alongside survival data. The primary end point of change in vascular calcification at 52 weeks showed no significant difference between arms. As equivalent control of phosphate and iPTH was achieved in both arms secondary analyses were performed. This showed a significant regression of left ventricular hypertrophy and carotid intima-media thickness associated with phosphate but not iPTH reduction. Patients whose phosphate reduced during the study had a survival advantage when followed for 5 years (HR=10.2 (1.1, 104.5) P=0.049). The third part of this research was to investigate iPTH assay variability. We explored the variation in iPTH assays across the North West and paired this with regional audit data. This study showed that despite there being significant variation among iPTH assays across the region the variation in clinical management was still accounting for some variation in achieving PTH targets.In conclusion, serum phosphate, within the normal laboratory range, is associated with an increased mortality in CKD patients. Haemodialysis patients may have improvement of cardiovascular outcomes with tight control of secondary hyperparathyroidism, by whichever therapeutic means. Intact PTH assays variation may alter our clinical management but variation in practice still affects guideline achievement.
Subjects/Keywords: 616.6; Chronic Kidney Disease; CKD-MBD; Phosphate; PTH; Cinacalcet; vascular stiffness; vascular calcification; left ventricular hypertrophy; bone mineral density
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APA (6th Edition):
Eddington, H. (2013). Improving the outcomes of patients with chronic kidney disease-mineral bone disorder. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/improving-the-outcomes-of-patients-with-chronic-kidney-disease – mineral-bone-disorder(0c72d2af-4523-43c4-a1f9-95ecb304e5ac).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566606
Chicago Manual of Style (16th Edition):
Eddington, Helen. “Improving the outcomes of patients with chronic kidney disease-mineral bone disorder.” 2013. Doctoral Dissertation, University of Manchester. Accessed February 27, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/improving-the-outcomes-of-patients-with-chronic-kidney-disease – mineral-bone-disorder(0c72d2af-4523-43c4-a1f9-95ecb304e5ac).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566606.
MLA Handbook (7th Edition):
Eddington, Helen. “Improving the outcomes of patients with chronic kidney disease-mineral bone disorder.” 2013. Web. 27 Feb 2021.
Vancouver:
Eddington H. Improving the outcomes of patients with chronic kidney disease-mineral bone disorder. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Feb 27].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/improving-the-outcomes-of-patients-with-chronic-kidney-disease – mineral-bone-disorder(0c72d2af-4523-43c4-a1f9-95ecb304e5ac).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566606.
Council of Science Editors:
Eddington H. Improving the outcomes of patients with chronic kidney disease-mineral bone disorder. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/improving-the-outcomes-of-patients-with-chronic-kidney-disease – mineral-bone-disorder(0c72d2af-4523-43c4-a1f9-95ecb304e5ac).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566606
26.
Takaori, Koji.
Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis
.
Degree: 2018, Kyoto University
URL: http://hdl.handle.net/2433/232126
Subjects/Keywords: acute kidney injury (AKI);
chronic kidney disease (CKD);
proximal tubule injury;
renal fibrosis
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APA (6th Edition):
Takaori, K. (2018). Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis
. (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/232126
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Takaori, Koji. “Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis
.” 2018. Thesis, Kyoto University. Accessed February 27, 2021.
http://hdl.handle.net/2433/232126.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Takaori, Koji. “Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis
.” 2018. Web. 27 Feb 2021.
Vancouver:
Takaori K. Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis
. [Internet] [Thesis]. Kyoto University; 2018. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2433/232126.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Takaori K. Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis
. [Thesis]. Kyoto University; 2018. Available from: http://hdl.handle.net/2433/232126
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
The Ohio State University
27.
Jackson, Ashley R.
Significance of Renal Urothelium During Development and
Disease.
Degree: PhD, Integrated Biomedical Science Graduate
Program, 2016, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1459778047
► Congenital obstructive nephropathy is the most common cause of chronic kidney disease in children and represents a tremendous societal burden in terms of morbidity and…
(more)
▼ Congenital obstructive nephropathy is the most common
cause of
chronic kidney disease in children and represents a
tremendous societal burden in terms of morbidity and mortality.
Despite surgical intervention, more than half of the children with
congenital obstructive nephropathy progress to end stage renal
disease mandating a great need to develop an appropriate mouse
model to directly assess the molecular pathways involved with
disease pathogenesis. Our lab has identified a unique transgenic
mouse line, designated mgb for megabladder that develops overt
urinary tract obstruction in utero. Affected mice exhibit
hydroureteronephrosis and progressive renal failure after birth
providing an ideal model for the identification of molecular
pathways involved in
disease pathogenesis and the interrogation of
diagnostic markers and therapeutic targets for children with
congenital obstructive nephropathy.After developing a non-invasive
technique to stratify
disease progression by measuring
hydronephrosis, we evaluated global renal transcriptomes in mgb
mice. Most studies focus on the nephron, while our transcriptome
analysis revealed an urothelial gene signature associated with
worsening hydronephrosis. Although little is known about renal
urothelium, its alterations during congenital obstructive
nephropathy represent some of the earliest identified. Among the
alterations, we identified an increase in urothelial proliferation,
which correlated with an increase in expression of the progenitor
cell marker Krt14. We found that the single cell layered renal
urothelium adapted to obstruction by developing multilayered
bladder-like characteristics. Schematically reconstructed
proliferative regions revealed that some of the most dynamic were
those juxtaposed to large neurovascular bundles. We found expanded
and de novo expression of hallmark urothelial specialization
markers, including a family of proteins with a largely unknown
function in the
kidney, uroplakins. From this, we hypothesized that
modifications in the renal urothelium may transiently alter
membrane permeability and cellular function. This relatively
unknown tissue, and its unique cellular and molecular components
may shed light on novel mechanisms for the activation of submucosal
myofibroblasts during the initiation of fibrosis during
chronic
kidney disease. Finding collagen deposition just immediately
underlying the renal urothelium basement membrane supports a role
for this tissue in adaptation to congenital obstructive
nephropathy. Very little is known about the renal urothelium.
Expression of uroplakins in the renal urothelium is controversial,
let alone the fact that we have little understanding of their
function. Since pathogenesis during
chronic kidney disease involves
this tissue and these genes, we proposed to identify their roles
within the normal urinary tract before targeting them in the
context of obstruction. Insomuch, we identified the impact of Upk1b
genetic ablation on urothelium using the Upk1bRFP/RFP mouse. After
validating that the homozygous…
Advisors/Committee Members: McHugh, Kirk (Advisor).
Subjects/Keywords: Biomedical Research; urothelium; renal urothelium; bladder; kidney; megabladder; congenital obstructive nephropathy; CON; chronic kidney disease; CKD; hydronephrosis; uroplakin; uroplakin 1b; upk1b; duplicated collecting system
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APA ·
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MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jackson, A. R. (2016). Significance of Renal Urothelium During Development and
Disease. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1459778047
Chicago Manual of Style (16th Edition):
Jackson, Ashley R. “Significance of Renal Urothelium During Development and
Disease.” 2016. Doctoral Dissertation, The Ohio State University. Accessed February 27, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1459778047.
MLA Handbook (7th Edition):
Jackson, Ashley R. “Significance of Renal Urothelium During Development and
Disease.” 2016. Web. 27 Feb 2021.
Vancouver:
Jackson AR. Significance of Renal Urothelium During Development and
Disease. [Internet] [Doctoral dissertation]. The Ohio State University; 2016. [cited 2021 Feb 27].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1459778047.
Council of Science Editors:
Jackson AR. Significance of Renal Urothelium During Development and
Disease. [Doctoral Dissertation]. The Ohio State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1459778047
Vrije Universiteit Amsterdam
28.
Vervloet, M.G.
Managing disorders of bone and mineral metabolism in chronic kidney disease
.
Degree: 2012, Vrije Universiteit Amsterdam
URL: http://hdl.handle.net/1871/33437
Subjects/Keywords: Chronic kidney disease; mineral metabolism; Bone disease; CKD-MBD; FGF23; klotho; phosphate
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APA ·
Chicago ·
MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vervloet, M. G. (2012). Managing disorders of bone and mineral metabolism in chronic kidney disease
. (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/33437
Chicago Manual of Style (16th Edition):
Vervloet, M G. “Managing disorders of bone and mineral metabolism in chronic kidney disease
.” 2012. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed February 27, 2021.
http://hdl.handle.net/1871/33437.
MLA Handbook (7th Edition):
Vervloet, M G. “Managing disorders of bone and mineral metabolism in chronic kidney disease
.” 2012. Web. 27 Feb 2021.
Vancouver:
Vervloet MG. Managing disorders of bone and mineral metabolism in chronic kidney disease
. [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2012. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/1871/33437.
Council of Science Editors:
Vervloet MG. Managing disorders of bone and mineral metabolism in chronic kidney disease
. [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2012. Available from: http://hdl.handle.net/1871/33437
University of Lund
29.
Önnerhag, Kristina.
Liver-related complications and metabolic comorbidities
during long-term follow-up of patients with Non-Alcoholic Fatty
Liver Disease.
Degree: 2019, University of Lund
URL: https://lup.lub.lu.se/record/65633610-45c3-4220-b4be-33ee09489c4c
;
https://portal.research.lu.se/ws/files/62375015/Avhandling_Kristina_nnerhag.pdf
► Background: Non-alcoholic fatty liver disease (NAFLD) is highly associated with the metabolic syndrome, and due to increasing prevalence of for example obesity it is now…
(more)
▼ Background: Non-alcoholic fatty liver disease
(NAFLD) is highly associated with the metabolic syndrome, and due
to increasing prevalence of for example obesity it is now the most
common liver disease in the world. A minority progress to advanced
fibrosis/cirrhosis, which is associated with increased mortality,
but it is not entirely clear which patients who have an increased
risk of fibrosis. General aim:To describe the long-term clinical
development and prognosis of biopsy-proven NAFLD, focusing on
liver-related morbidity, metabolic comorbidities and mortality.
Methods: In Paper 1, patients with long-term insulin resistance, a
risk factor for developing NAFLD, were invited to assessment of
liver function tests and if elevated patients were further examined
for a diagnosis of NAFLD. In Paper 2-4, all patients with
biopsy-proven NAFLD in Malmö, Sweden 1978-2006 were identified, and
further assessed with an extensive review of patients’ medical
files regarding long-term risk of cirrhosis development,
liver-related events, metabolic comorbidities, chronic kidney
disease and mortality, and the use of non-invasive fibrosis scoring
system in early indentification of these risk patients. Follow-up
time in all four papers were between 17-27 years. Results: Only 15%
(n=25) of patients with long-term insulin resistance in Paper 1 had
elevated liver function tests at long-term follow-up, and of these
only 23.8% had NAFLD diagnosed with imaging. Patients with NAFLD
had significantly higher prevalence of the metabolic syndrome and
progressive insulin resistance (type 2 diabetes mellitus (T2DM) or
impaired fasting glucose). Of all patients with biopsy-proven NAFLD
included in Paper 2-4 survival was significantly lower than a
reference population. The prevalence of cirrhosis at follow-up was
17%, and 13.8% developed liver-related events. Hepatocellular
cancer (HCC) was diagnosed in nearly 6% of patients. The most
common metabolic comorbidity at follow-up was hypertension in 66%
af patients, and T2DM in 53%. NAFLD patients with advanced fibrosis
(stage 3-4) had significantly higher prevalence of T2DM. Chronic
kidney disease (CKD) was prevalent in 12.5% at inclusion, but only
significantly higher in the highest age group (> 55 years). At
follow-up 37.5% had developed CKD, however not significantly
different to the reference group. NAFLD patients with long-term CKD
had significantly higher mortality, which was explained by an
increased prevalence of metabolic comorbidities including T2DM, not
CKD per se. When calculating simple non-invasive fibrosis scoring
systems (inclucing NAFLD fibrosis score and FIB-4 index) from the
time of biopsy, these could with acceptable accuracy identify NAFLD
patients with an increased risk of overall mortality, future
liver-related events, T2DM, cardiovascular disease and CKD.
Conclusions: NAFLD development in patients with long-term insulin
resistance is associated with a progress of metabolic
comorbidities. Of all patients with biopsy-proven NAFLD 17%
developed cirrhosis and 6 % HCC at long-term…
Subjects/Keywords: Medical and Health Sciences; Chronic kidney disease (CKD); Epidemiology; Fibrosis; Hepatocellular cancer; Insulin resistance; Liver cirrhosis; Metabolic syndrome; NAFLD; NASH; Non-alcoholic fatty liver disease; non-alcoholic steatohepatitis
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Önnerhag, K. (2019). Liver-related complications and metabolic comorbidities
during long-term follow-up of patients with Non-Alcoholic Fatty
Liver Disease. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/65633610-45c3-4220-b4be-33ee09489c4c ; https://portal.research.lu.se/ws/files/62375015/Avhandling_Kristina_nnerhag.pdf
Chicago Manual of Style (16th Edition):
Önnerhag, Kristina. “Liver-related complications and metabolic comorbidities
during long-term follow-up of patients with Non-Alcoholic Fatty
Liver Disease.” 2019. Doctoral Dissertation, University of Lund. Accessed February 27, 2021.
https://lup.lub.lu.se/record/65633610-45c3-4220-b4be-33ee09489c4c ; https://portal.research.lu.se/ws/files/62375015/Avhandling_Kristina_nnerhag.pdf.
MLA Handbook (7th Edition):
Önnerhag, Kristina. “Liver-related complications and metabolic comorbidities
during long-term follow-up of patients with Non-Alcoholic Fatty
Liver Disease.” 2019. Web. 27 Feb 2021.
Vancouver:
Önnerhag K. Liver-related complications and metabolic comorbidities
during long-term follow-up of patients with Non-Alcoholic Fatty
Liver Disease. [Internet] [Doctoral dissertation]. University of Lund; 2019. [cited 2021 Feb 27].
Available from: https://lup.lub.lu.se/record/65633610-45c3-4220-b4be-33ee09489c4c ; https://portal.research.lu.se/ws/files/62375015/Avhandling_Kristina_nnerhag.pdf.
Council of Science Editors:
Önnerhag K. Liver-related complications and metabolic comorbidities
during long-term follow-up of patients with Non-Alcoholic Fatty
Liver Disease. [Doctoral Dissertation]. University of Lund; 2019. Available from: https://lup.lub.lu.se/record/65633610-45c3-4220-b4be-33ee09489c4c ; https://portal.research.lu.se/ws/files/62375015/Avhandling_Kristina_nnerhag.pdf
RMIT University
30.
Paranagama, D.
Chronic kidney disease of unknown origin in Sri Lanka and its relation to drinking water supplies.
Degree: 2014, RMIT University
URL: http://researchbank.rmit.edu.au/view/rmit:161330
► Chronic Kidney Disease (CKD) is a major health concern in North Central Province (NCP) of Sri Lanka. Anuradhapura and Polonnaruwa are the two most affected…
(more)
▼ Chronic Kidney Disease (CKD) is a major health concern in North Central Province (NCP) of Sri Lanka. Anuradhapura and Polonnaruwa are the two most affected districts in NCP. Excess fluoride in groundwater used for drinking is suspected to cause CKD. This research was designed to identify possible CKD causative agents in drinking water of NCP. An analytical framework was developed to analyze drinking water sample data collected from shallow wells of CKD patients and non-patients in Anuradhapura and Polonnaruwa districts. Statistical analytical methods included Univariate Analysis of Variance (ANOVA) followed by Dunnett’s T3 post hoc test, Kruskal Wallis (KW) test followed by Mann-Whitney’s post hoc test, Factorial analysis followed by reliability tests and Discriminant analysis. A secondary data set obtained from CKD endemic and non-endemic areas were also analyzed independently using the same analytical techniques to validate results. Total results indicated that sodium and fluoride combination was the probable factor in drinking water of CKD patients. Sodium and fluoride as a combined factor was non-existent or less significant than magnesium and fluoride combination in non-patients. Even though Cd2+ and As3- were suspected to be causing CKD, As3- was not detected in Anuradhapura and Polonnaruwa samples and Cd2+ was insignificant in Polonnaruwa samples. Rainwater harvesting (RWH) was proposed as a mitigation measure to the CKD endemic areas as an alternative to groundwater supplies. RWH tanks were estimated for eight rainfall stations in Anuradhapura and Polonnaruwa districts, using Mass Curve Method. For a four member household with average drinking water demand of 6 L/capita/day the rainwater tank sizes estimated varied between 3000 and 5100 L. Minimum runoff surface area estimations required to fill those tanks were between 6 to 18 m2. As such estimated tank sizes were of manageable size and can be applied in Anuradhapura and Polonnaruwa districts at household levels to supply drinking water as an alternative to groundwater sources. Removal of fluoride from drinking water obtained from ground water sources was the other CKD mitigation technique proposed in this research. Lab experiments showed that turmeric powder has fluoride removal capacity of 20% at concentrations between 2- 20mg/L. Langmuir Isotherm better fitted experimental results indicating monolayer adsorption. Intra-particle mass transfer diffusion equation indicated adsorption is governed by diffusion within the pores of the adsorbent. Column experiments showed that Fluoride adsorption by turmeric could be attributed to the processes of ion-binding and ion-exchange between turmeric and fluoride. After column experiments turmeric was regenerated with 1.0M NaOH. With the test results it was concluded that turmeric powder is a potential material for effective removal of fluoride.
Subjects/Keywords: Fields of Research; Chronic Kidney Disease (CKD); North Central province of Sri Lanka; ANOVA; Kruskal Wallis; Discriminant analysis; Factorial analysis.; Rainwater harvesting; Absorption
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APA ·
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Paranagama, D. (2014). Chronic kidney disease of unknown origin in Sri Lanka and its relation to drinking water supplies. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:161330
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Paranagama, D. “Chronic kidney disease of unknown origin in Sri Lanka and its relation to drinking water supplies.” 2014. Thesis, RMIT University. Accessed February 27, 2021.
http://researchbank.rmit.edu.au/view/rmit:161330.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Paranagama, D. “Chronic kidney disease of unknown origin in Sri Lanka and its relation to drinking water supplies.” 2014. Web. 27 Feb 2021.
Vancouver:
Paranagama D. Chronic kidney disease of unknown origin in Sri Lanka and its relation to drinking water supplies. [Internet] [Thesis]. RMIT University; 2014. [cited 2021 Feb 27].
Available from: http://researchbank.rmit.edu.au/view/rmit:161330.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Paranagama D. Chronic kidney disease of unknown origin in Sri Lanka and its relation to drinking water supplies. [Thesis]. RMIT University; 2014. Available from: http://researchbank.rmit.edu.au/view/rmit:161330
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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. 
Open Access Theses and Dissertations
