subject:( Cardiovascular disease)

Anna University

1. Jamuna devi A. Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;.

Degree: Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach, 2015, Anna University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/35496

►

Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach newline newlineCardiovascular disease is the leading cause of death… (more)

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

A, J. d. (2015). Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;. (Thesis). Anna University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/35496

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

A, Jamuna devi. “Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;.” 2015. Thesis, Anna University. Accessed March 07, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/35496.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

A, Jamuna devi. “Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;.” 2015. Web. 07 Mar 2021.

Vancouver:

A Jd. Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;. [Internet] [Thesis]. Anna University; 2015. [cited 2021 Mar 07]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35496.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

A Jd. Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;. [Thesis]. Anna University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35496

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Aslibekyan, Stella. Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study.

Degree: PhD, Epidemiology, 2011, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:11241/

► Abstract of Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study, by Stella Aslibekyan, Ph.D., Brown University, May 2011Cardiovascular disease is… (more)

▼ Abstract of Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study, by Stella Aslibekyan, Ph.D., Brown University, May 2011Cardiovascular disease is the leading cause of death, disability, and healthcare expenses throughout the world, including low- and middle-income countries. However, the gap in cardiovascular epidemiology research between the developed and the developing worlds remains substantial. This dissertation aims to elucidate the role that genetic and environmental predictors play in the etiology of nonfatal myocardial infarction in a population of Costa Rican adults undergoing nutritional transition. In the first chapter, we developed and validated the first cardiovascular risk score to be exclusively based on lifestyle predictors and derived in a non-Western population. Our score presents a simple, low-cost alternative to the existing measures of cardiovascular risk stratification in resource-limited settings. In the second and third chapters, we investigated potential associations between genetic variation in desaturases and elongases, polyunsaturated fatty acid metabolism, and the risk of heart disease among Costa Rican adults. Our findings showed robust associations between six common single nucleotide polymorphisms in the desaturase genes and adipose tissue polyunsaturated fatty acids, as well as serum triglycerides and C-reactive protein, but not myocardial infarction. We also found evidence that variation in desaturase genes modified the association between dietary intake of alpha-linolenic acid and serum low-density lipoprotein cholesterol. Futhermore, we established a novel association between variation in the gene coding for fatty acid elongase-5 and serum low density lipoprotein- and total cholesterol. Finally, we demonstrated null associations of elongase polymorphisms with adipose tissue fatty acids, markers of systemic inflammation, serum high-density lipoprotein cholesterol and triglycerides, and nonfatal myocardial infarction. Future studies are warranted to replicate the observed associations as well as to elucidate the biological mechanisms underlying the effect of genetic variation in elongases and desaturases on cardiovascular health, especially in populations undergoing nutritional and epidemiologic transitions. Advisors/Committee Members: Baylin, Ana (Director), Linkletter, Crystal (Reader), Loucks, Eric (Reader), Ordovas, Jose (Reader).

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

Aslibekyan, S. (2011). Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11241/

Chicago Manual of Style (16^th Edition):

Aslibekyan, Stella. “Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study.” 2011. Doctoral Dissertation, Brown University. Accessed March 07, 2021. https://repository.library.brown.edu/studio/item/bdr:11241/.

MLA Handbook (7^th Edition):

Aslibekyan, Stella. “Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study.” 2011. Web. 07 Mar 2021.

Vancouver:

Aslibekyan S. Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study. [Internet] [Doctoral dissertation]. Brown University; 2011. [cited 2021 Mar 07]. Available from: https://repository.library.brown.edu/studio/item/bdr:11241/.

Council of Science Editors:

Aslibekyan S. Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study. [Doctoral Dissertation]. Brown University; 2011. Available from: https://repository.library.brown.edu/studio/item/bdr:11241/

3. DiBello, Julia R. Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans.

Degree: PhD, Division of Biology and Medicine. Epidemiology, 2009, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:82/

► Traditional analyses in nutritional epidemiology relate single nutrients or foods to disease risk. Dietary pattern analysis is increasingly preferred to analysis of single nutrients as… (more)

▼ Traditional analyses in nutritional epidemiology relate single nutrients or foods to disease risk. Dietary pattern analysis is increasingly preferred to analysis of single nutrients as patterns account for combinations of nutrients that may be interactive or synergistic and create uncorrelated patterns from many highly correlated nutrients that may have small or undetectable effects on disease risk when considered alone. Principal component analysis (PCA), one of the major methods for deriving dietary patterns, combines correlated variables into weighted summations that "account for" much of the information contained in the original variables. One limitation of this approach when attempting to relate dietary patterns to the occurrence of disease is that patterns explaining large percentages of variation in food intake do not necessarily explain an equivalent amount of variation in nutrient intake. The effects of diet on the risk of disease are likely mediated through specific macro and micronutrients and thus patterns derived using PCA may not be associated with disease risk. Reduced rank regression (RRR) and partial least squares regression (PLS) are proposed alternatives to PCA and include knowledge about intermediary variables (response variables) on the pathway to disease in the derivation of dietary patterns. These three methods (PCA, PLS, RRR) were first applied in a Costa Rican population. All three methods identified a similar dietary pattern associated with significant decreased risk of first incident myocardial infarction (MI). However, PLS and PCA identified additional patterns significantly associated with MI risk and characterized by nutrients not previously considered to play a major role in the pathogenesis of MI in this population. PLS was subsequently applied among Samoan Islanders resulting in neo-traditional and more modern dietary patterns that were related to metabolic syndrome occurrence. Finally, PCA was applied using National Health and Nutritional Examination Data (NHANES) among US adolescents 12-19 years of age and patterns related to decreased fasting plasma glucose and increased body mass index were derived. The flexibility allowed by PLS and PCA, to derive patterns partially (PLS) or completely (PCA) unconstrained by the choice of response variables is important to consider when deciding which method to use. Advisors/Committee Members: Baylin, Ana (director), McGarvey, Stephen (reader), Goldberg, Robert (reader), Kraft, Peter (reader).

Subjects/Keywords: cardiovascular disease

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APA (6^th Edition):

DiBello, J. R. (2009). Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:82/

Chicago Manual of Style (16^th Edition):

DiBello, Julia R. “Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans.” 2009. Doctoral Dissertation, Brown University. Accessed March 07, 2021. https://repository.library.brown.edu/studio/item/bdr:82/.

MLA Handbook (7^th Edition):

DiBello, Julia R. “Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans.” 2009. Web. 07 Mar 2021.

Vancouver:

DiBello JR. Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans. [Internet] [Doctoral dissertation]. Brown University; 2009. [cited 2021 Mar 07]. Available from: https://repository.library.brown.edu/studio/item/bdr:82/.

Council of Science Editors:

DiBello JR. Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans. [Doctoral Dissertation]. Brown University; 2009. Available from: https://repository.library.brown.edu/studio/item/bdr:82/

4. Sands, Megan Rae. Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease.

Degree: PhD, Epidemiology, 2012, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:297542/

► A large body of evidence from both observation studies and clinical trials suggests that sleep quality and quantity is implicated in the pathogenesis of cardiovascular… (more)

▼ A large body of evidence from both observation studies and clinical trials suggests that sleep quality and quantity is implicated in the pathogenesis of cardiovascular disease (CVD). Over the past century, westernized societies have seen a marked shift in sleep patterns, including a substantial decrease in sleep duration and increased reporting of poor sleep quality. CVD accounts for 1 in 2.9 deaths in the United States. Given the significant burden of this disease, it is important to identify novel opportunities for prevention. This dissertation addresses the association between sleep and CVD risk by examining underlying subclinical mechanisms, as well as incident coronary outcomes. The association between objectively assessed sleep duration and carotid intima-media thickness (IMT), a subclinical biomarker of CVD, is examined among middle-aged adults in the Coronary Artery Risk Development in Young Adults study. Findings suggest that shorter sleep duration was associated with greater IMT among men but not women after controlling for demographics and CVD risk markers. The association between sleep duration and sleep quality with coronary outcomes is then assessed in postmenopausal women participating in the Women’s Health Initiative cohort study. Hazard ratios were computed using Cox proportional hazards models, and findings suggested that among postmenopausal women, those individuals with prolonged sleep and with a high level of insomnia had over double the risk of coronary heart disease (CHD). Habitual snoring, a correlate and early symptom of sleep apnea, was also associated with a modest increased risk of incident CHD and CVD, independent of demographics and risk markers. This work has demonstrated that one must take gender and age into account when assessing the impact of sleep on coronary disease. Furthermore, despite the large number of epidemiologic studies supporting a U-shaped association between sleep duration and CVD, it is increasingly important to consider characteristics of sleep quality, such as sleep disturbance, insomnia and apnea risk, when assessing the sleep duration and CVD association. Additional studies are needed to elucidate why findings differ by age group and gender, and to identify additional biological mechanisms underlying the observed associations. Advisors/Committee Members: Loucks, Eric (Director), Eaton, Charles (Reader), Lu, Bing (Reader), , (Director).

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

Sands, M. R. (2012). Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:297542/

Chicago Manual of Style (16^th Edition):

Sands, Megan Rae. “Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease.” 2012. Doctoral Dissertation, Brown University. Accessed March 07, 2021. https://repository.library.brown.edu/studio/item/bdr:297542/.

MLA Handbook (7^th Edition):

Sands, Megan Rae. “Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease.” 2012. Web. 07 Mar 2021.

Vancouver:

Sands MR. Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease. [Internet] [Doctoral dissertation]. Brown University; 2012. [cited 2021 Mar 07]. Available from: https://repository.library.brown.edu/studio/item/bdr:297542/.

Council of Science Editors:

Sands MR. Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease. [Doctoral Dissertation]. Brown University; 2012. Available from: https://repository.library.brown.edu/studio/item/bdr:297542/

5. joyce, nina. Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20.

Degree: PhD, Epidemiology, 2016, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:674094/

► In 2008 the American Academy of Pediatrics (AAP) updated a previous set of guidelines on treatment of hypercholesterolemia in children from 1998. Despite evidence linking… (more)

▼ In 2008 the American Academy of Pediatrics (AAP) updated a previous set of guidelines on treatment of hypercholesterolemia in children from 1998. Despite evidence linking early treatment to reduced risk of CVD later in life, the 2008 AAP guidelines proved controversial when they suggested more aggressive screening and treatment of LDL-C in children and lowering the minimum age of pharmacological treatment in form of lipid lowering therapy (LLT) from 10 to 8 years old, for cases in which lifestyle modifications fail to reduce serum cholesterol to acceptable levels. Critics feared that the guidelines would lead to excessive use of pharmacological treatment, and more specifically, potentially inappropriate pharmacological treatment for children with life-style related dyslipidemias, such as those related to obesity. Included in the controversy was the fact that there were no long-term studies of the safety of LLT in children. While statins are considered to have a beneficial safety profile in adults, it was not clear that this extended to children. And in fact, there were reasons to believe that the risks in children may differ from that in adults, given both their level of development and the longer duration of expected use. However, lost in the controversy is the absence of a comprehensive evaluation of the use and safety of LLT treatment in children. The objective of this proposal is to evaluate safety of statin treatment and patterns of LLT initiation and adherence in children ages 8 to 20. In specific we studied patterns of LLT use, as both a function of initiation of LLT and adherence post-initiation. Addition, we studied the risk of diabetes associated with statin use in children- a risk which has recently been identified in adults and which could have a significant effect on the risk-benefit assessment of statin treatment in childhood. This will represent the first assessment of pediatric LLT during a period when the earliest children subjected to the obesity epidemic are coming into young adulthood. Advisors/Committee Members: Wellenius, Gregory (Director), Zachariah, Justin (Reader), Trivedi, Amal (Reader), Eaton, Charles (Reader).

Subjects/Keywords: cardiovascular disease

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APA (6^th Edition):

joyce, n. (2016). Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:674094/

Chicago Manual of Style (16^th Edition):

joyce, nina. “Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20.” 2016. Doctoral Dissertation, Brown University. Accessed March 07, 2021. https://repository.library.brown.edu/studio/item/bdr:674094/.

MLA Handbook (7^th Edition):

joyce, nina. “Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20.” 2016. Web. 07 Mar 2021.

Vancouver:

joyce n. Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20. [Internet] [Doctoral dissertation]. Brown University; 2016. [cited 2021 Mar 07]. Available from: https://repository.library.brown.edu/studio/item/bdr:674094/.

Council of Science Editors:

joyce n. Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20. [Doctoral Dissertation]. Brown University; 2016. Available from: https://repository.library.brown.edu/studio/item/bdr:674094/

6. Agha, golareh. Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease.

Degree: PhD, Epidemiology, 2014, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:386164/

► Cardiovascular disease (CVD) is complex and chronic in nature, resulting over time from multiple factors. First, CVD rarely develops due to the presence of a… (more)

▼ Cardiovascular disease (CVD) is complex and chronic in nature, resulting over time from multiple factors. First, CVD rarely develops due to the presence of a single risk factor in isolation; rather, multiple risk factors contribute to disease independently, cumulatively, and interactively. Furthermore, risk for CVD begins early in life, with growing evidence that exposures acting as early as the fetal period may have an impact on CVD that manifests in adulthood. Understanding the etiology of CVD thus requires careful consideration of such complex processes and trajectories; this dissertation used data from two prospective studies in order to better address such complexities. In the Women’s Health Initiative Observational study, the effect of a combination of four lifestyle factors on risk of heart failure (HF) was examined. Meeting the ‘healthy’ criteria for a higher number of lifestyle factors was associated with progressively lower risk of HF among post-menopausal women. Risk of HF was substantially lower among those who met all four healthy lifestyle criteria as compared with those who met the healthy criterion for any one factor. In the Longitudinal Effect on Aging Perinatal (LEAP) study, the biological mechanisms by which exposures in the fetal period may impact adiposity, an important and prevalent CVD risk factor, were explored. A particular biological mechanism of interest is the programming and regulation of gene expression through the epigenetic mechanism of DNA methylation. Accordingly, the impact of prenatally-assessed socioeconomic position on adulthood DNA methylation patterns was investigated among men and women from the LEAP study. Prenatal socioeconomic position was associated with adulthood adipose tissue DNA methylation patterns in women and not men, while no associations was seen with blood tissue DNA Methylation. The association between DNA methylation and adiposity was also investigated; adipose tissue DNA methylation patterns were associated with adiposity, whereas no association was observed in blood. In conclusion, results from this dissertation research suggest that multiple risk factors contribute collectively to CVD development. In addition, exposures early in life may contribute to adulthood CVD risk, and epigenetic mechanisms may be involved. Advisors/Committee Members: Loucks, Eric (Director), Houseman, E. Andres (Reader), Kelsey, Karl (Reader), Eaton, Charles (Reader).

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

Agha, g. (2014). Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:386164/

Chicago Manual of Style (16^th Edition):

Agha, golareh. “Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease.” 2014. Doctoral Dissertation, Brown University. Accessed March 07, 2021. https://repository.library.brown.edu/studio/item/bdr:386164/.

MLA Handbook (7^th Edition):

Agha, golareh. “Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease.” 2014. Web. 07 Mar 2021.

Vancouver:

Agha g. Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease. [Internet] [Doctoral dissertation]. Brown University; 2014. [cited 2021 Mar 07]. Available from: https://repository.library.brown.edu/studio/item/bdr:386164/.

Council of Science Editors:

Agha g. Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease. [Doctoral Dissertation]. Brown University; 2014. Available from: https://repository.library.brown.edu/studio/item/bdr:386164/

7. Gong, Jian. Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica.

Degree: PhD, Epidemiology, 2011, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:11170/

► Abstract of "Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica" by Jian Gong, Ph.D., Brown University, May 2011Cardiovascular disease, obesity, and… (more)

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

Gong, J. (2011). Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11170/

Chicago Manual of Style (16^th Edition):

Gong, Jian. “Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica.” 2011. Doctoral Dissertation, Brown University. Accessed March 07, 2021. https://repository.library.brown.edu/studio/item/bdr:11170/.

MLA Handbook (7^th Edition):

Gong, Jian. “Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica.” 2011. Web. 07 Mar 2021.

Vancouver:

Gong J. Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica. [Internet] [Doctoral dissertation]. Brown University; 2011. [cited 2021 Mar 07]. Available from: https://repository.library.brown.edu/studio/item/bdr:11170/.

Council of Science Editors:

Gong J. Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica. [Doctoral Dissertation]. Brown University; 2011. Available from: https://repository.library.brown.edu/studio/item/bdr:11170/

Wake Forest University

8. Azeem, Amir. Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/39023

► In this thesis, we will seek to evaluate the role of a biomarker, hemoglobin A1c, as a predictor of incident cardiovascular disease and all-cause mortality… (more)

Subjects/Keywords: Cardiovascular Disease

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APA (6^th Edition):

Azeem, A. (2013). Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/39023

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Azeem, Amir. “Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality.” 2013. Thesis, Wake Forest University. Accessed March 07, 2021. http://hdl.handle.net/10339/39023.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Azeem, Amir. “Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality.” 2013. Web. 07 Mar 2021.

Vancouver:

Azeem A. Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10339/39023.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Azeem A. Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/39023

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

9. Goldman, Matthew Patrick. Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis.

Degree: 2018, Wake Forest University

URL: http://hdl.handle.net/10339/93046

► Peripheral arterial disease (PAD) is a progressive disease that affects up to 10% of the population worldwide. The burden of this disease on individuals, health… (more)

Subjects/Keywords: Cardiovascular Disease

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APA (6^th Edition):

Goldman, M. P. (2018). Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/93046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Goldman, Matthew Patrick. “Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis.” 2018. Thesis, Wake Forest University. Accessed March 07, 2021. http://hdl.handle.net/10339/93046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Goldman, Matthew Patrick. “Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis.” 2018. Web. 07 Mar 2021.

Vancouver:

Goldman MP. Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis. [Internet] [Thesis]. Wake Forest University; 2018. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10339/93046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Goldman MP. Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis. [Thesis]. Wake Forest University; 2018. Available from: http://hdl.handle.net/10339/93046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State Polytechnic University – Pomona

10. Chen, Yee-Chi (Christina). The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk.

Degree: MS, Agriculture, 2014, California State Polytechnic University – Pomona

URL: http://hdl.handle.net/10211.3/123899

► Many functional foods have been studied for their ability to lower cardiovascular disease (CVD) risk. Avocados contain significant amounts of cardioprotective components such as monounsaturated… (more)

Subjects/Keywords: cardiovascular disease (CVD)

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APA (6^th Edition):

Chen, Y. (. (2014). The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk. (Masters Thesis). California State Polytechnic University – Pomona. Retrieved from http://hdl.handle.net/10211.3/123899

Chicago Manual of Style (16^th Edition):

Chen, Yee-Chi (Christina). “The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk.” 2014. Masters Thesis, California State Polytechnic University – Pomona. Accessed March 07, 2021. http://hdl.handle.net/10211.3/123899.

MLA Handbook (7^th Edition):

Chen, Yee-Chi (Christina). “The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk.” 2014. Web. 07 Mar 2021.

Vancouver:

Chen Y(. The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk. [Internet] [Masters thesis]. California State Polytechnic University – Pomona; 2014. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10211.3/123899.

Council of Science Editors:

Chen Y(. The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk. [Masters Thesis]. California State Polytechnic University – Pomona; 2014. Available from: http://hdl.handle.net/10211.3/123899

University of Oxford

11. Rinze, Ruth E. Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability.

Degree: PhD, 2011, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298

► The vascular endothelium plays a critical role in the regulation of vascular homeostasis. Endothelial cell injury, loss, survival and regeneration are important aspects in the… (more)

▼ The vascular endothelium plays a critical role in the regulation of vascular homeostasis. Endothelial cell injury, loss, survival and regeneration are important aspects in the response to vascular injury and pathogenesis of vascular disease. Re-endothelialization has been shown to be a key event in vascular repair after injury. Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key regulator of endothelial cell biology. Loss of NO bioavailability in endothelial dysfunction states is an early step in the development of atherosclerosis. The cofactor tetrahydrobiopterin (BH4) is essential for eNOS catalytic activity; when BH4 is limiting eNOS becomes enzymatically uncoupled, leading to the generation of superoxide instead of NO. eNOS function has been shown to be an important regulator of endothelial cell proliferation and survival as well as endothelial progenitor cell function. There is increasing evidence that the essential eNOS cofactor BH4 may enhance endothelial cell proliferation and endothelial progenitor function, both of which have the potential of enhancing vascular repair. The aim of this thesis is to evaluate the effect of BH4 bioavailability on endothelial cell growth in the absence and presence of vascular disease using primary endothelial cells from mice with genetic modifications in BH4 availability. Endothelial progenitor cell availability in lungs and bone marrow was investigated to address a second source for endothelial repair and potential therapeutic target. The duration of culture proved to be a major determinant of the biological phenotype of primary endothelial cells. Transgenic BH4 augmentation improved in vitro growth of primary endothelial cells in the presence but not in the absence of vascular disease. Endothelial progenitor cell content in lung tissue and bone marrow did not appear to be affected by transgenic BH4 augmentation. This thesis provides important new knowledge about the use of primary mouse endothelial cells in vascular research and insight into the role of BH4 availability on endothelial growth in a vascular disease setting.

Subjects/Keywords: 616.1; Cardiovascular disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rinze, R. E. (2011). Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298

Chicago Manual of Style (16^th Edition):

Rinze, Ruth E. “Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability.” 2011. Doctoral Dissertation, University of Oxford. Accessed March 07, 2021. http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298.

MLA Handbook (7^th Edition):

Rinze, Ruth E. “Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability.” 2011. Web. 07 Mar 2021.

Vancouver:

Rinze RE. Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability. [Internet] [Doctoral dissertation]. University of Oxford; 2011. [cited 2021 Mar 07]. Available from: http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298.

Council of Science Editors:

Rinze RE. Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability. [Doctoral Dissertation]. University of Oxford; 2011. Available from: http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298

University of Oxford

12. Sebag-Montefiore, Liam M. Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function.

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851

► Heart failure (HF) is a common, disabling and deadly condition that causes high rates of morbidity and mortality worldwide. It is widely recognised that the… (more)

▼ Heart failure (HF) is a common, disabling and deadly condition that causes high rates of morbidity and mortality worldwide. It is widely recognised that the failing heart is energy-starved, and that restoring energy homeostasis is a promising approach towards improving cardiac output. This thesis aims to address the role of energetics in the failing heart, by focussing on modulation of the creatine transporter (CrT). Creatine (Cr), together with the phosphocreatine shuttle, plays a vital role in maintaining energy supplies via ATP in times of high energy demand. Key to the regulation of intracellular [Cr] is the CrT, a Na+ and Cl- - dependent membrane transporter. Previous CrT genetic mouse models include a knockout model, found to still express cardiac CrT, and a cardiac-specific CrT overexpressing (OE) model with large variations in myocardial [Cr] between animals and Cr levels high enough to cause spontaneous hypertrophy. To overcome the shortfalls of this CrT-OE model, a novel in vivo model of temporal inducible expression of CrT is described, using a cardiac-specific tetracycline inducible (Tet-On) system. Ten transgenic lines (RCT) were created with a construct containing the CrT-HA (CrT cDNA with an haemagglutinin epitope tag), following successful doxycyline-inducibility in vitro. Eight lines showed germline transmission, with LV CrT OE achieved in an individual mouse that displayed double LV [Cr] compared to WT. Issues with the inducer line (rtTA) were ruled out by its use in the creation of a luciferase overexpressing mouse line; all mice tested demonstrated LV luciferase expression in response to doxycycline feeding. The failure to overexpress CrT could be attributed to position or copy number dependent suppression, or to position effect variegation in the case of the single OE mouse obtained. Subsequent work focussed on regulatory pathways in vitro in a cell line of mouse fibroblasts stably overexpressing CrT-HA. Post-translational modifications (PTMs) had been previously suggested to regulate CrT activity. Two N-linked glycosylation sites exist, in addition to the putative phosphorylation sites. Inhibition of glycosylation by tunicamycin led to decreased CrT activity, reflected by decreased Cr uptake capacity. Strategies to confirm the presence of phosphorylation were employed, including isolation of CrT-HA by immunoprecipitation and subsequent LC-MS / MS analysis to identify PTMs. Although the presence of CrT was confirmed in 5 different sized species- one previously unreported- inadequate sequence coverage prevented identification of any PTM sites. Tyrosine phosphorylation was not detected using a phosphospecific antibody on immunopurified CrT-HA. Candidate signalling pathways in vitro were then investigated to elucidate CrT regulation, namely the IGF 1R signalling pathway. This study included a cardiomyocyte-like mouse cell line (HL-1) in addition to 3T3-CrT-HA. Exposure of cells to extracellular insulin, growth hormone and IGF-1 led to increased Cr uptake of 125% - 300% of normal.…

Subjects/Keywords: 616.129; Cardiovascular disease

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APA (6^th Edition):

Sebag-Montefiore, L. M. (2012). Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851

Chicago Manual of Style (16^th Edition):

Sebag-Montefiore, Liam M. “Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function.” 2012. Doctoral Dissertation, University of Oxford. Accessed March 07, 2021. http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851.

MLA Handbook (7^th Edition):

Sebag-Montefiore, Liam M. “Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function.” 2012. Web. 07 Mar 2021.

Vancouver:

Sebag-Montefiore LM. Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function. [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2021 Mar 07]. Available from: http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851.

Council of Science Editors:

Sebag-Montefiore LM. Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function. [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851

Loyola University Chicago

13. Larimer, Karen Ann. Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois.

Degree: PhD, Nursing, 2011, Loyola University Chicago

URL: https://ecommons.luc.edu/luc_diss/199

► Background: Cardiovascular disease (CVD) is the number one cause of death in the United States and affects persons of all races and ethnicities. The… (more)

▼ Background: Cardiovascular disease (CVD) is the number one cause of death in the United States and affects persons of all races and ethnicities. The number of persons of Mexican ethnicity has increased significantly in the United States, notably in the community of Berwyn, a suburb of Chicago, IL where according to the U.S. 2010 census 60% of the community is now of Mexican descent. The factors that contribute to CVD risk in persons of Mexican decent within this community must be understood before culturally appropriate risk reduction strategies are designed and implemented. Purpose: The purpose of this community-based study is to gain a better understanding of selected social and physical health determinants and risk factors which may contribute to cardiovascular disease in people of Mexican descent in the community of Berwyn. Methods: The Healthy People 2010 model for assessing a community's health status guided this study. Multiple methods were used to characterize the prevalence of CVD risk factors among a community sample of Berwyn residents of Mexican descent. The impact of the selected social health determinants include language barriers, access to care, cultural behaviors, awareness of CVD and socioeconomic status and physical health determinants such as availability of parks and play lots, grocery stores and environmental pollution. Sources of data included: (1) community health screenings of 106 participants of Mexican descent who were assessed for blood pressure, total cholesterol, glucose, height, weight, body mass index, and age, (2) fifteen guided interviews of community key informants, (3) survey of participants in community/church-based CVD risk screenings, and (4) searches of publicly accessible internet databases related to the social and physical health determinants for this community. Data Analysis: Guided interviews were analyzed using standard qualitative procedures. STATA/MP version 1.1 was used for descriptive statistical analyses of the survey data and to determine proportions of individuals with abnormal risk values using accepted guidelines for cut-offs. The ARC geographic information system was used to plot locations of parks and stores within the community. Results: Risk prevalence data gleaned from interviews, in combination with quantitative results, revealed a triad of risk factors in this population. The most common risk factors among the 106 who participated in screenings were high body mass index (45% of the sample as overweight and additional 38% as obese), 52% with low HDL, 44% with elevated glucose, 35% with pre-hypertension; 33% with elevated total cholesterol. Reports from informants suggested that atherogenic diets and lack of physical activity among community members are common. However, key informant and individual community member interviews suggested that CVD does not rank as one of the top overall concerns for this Mexican population. Key informants also believed that lack of access to preventive health care is a common concern, with…

Subjects/Keywords: Cardiovascular Disease; Cardiovascular Risk; Hispanics; Mexicans; Nursing

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APA (6^th Edition):

Larimer, K. A. (2011). Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois. (Doctoral Dissertation). Loyola University Chicago. Retrieved from https://ecommons.luc.edu/luc_diss/199

Chicago Manual of Style (16^th Edition):

Larimer, Karen Ann. “Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois.” 2011. Doctoral Dissertation, Loyola University Chicago. Accessed March 07, 2021. https://ecommons.luc.edu/luc_diss/199.

MLA Handbook (7^th Edition):

Larimer, Karen Ann. “Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois.” 2011. Web. 07 Mar 2021.

Vancouver:

Larimer KA. Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois. [Internet] [Doctoral dissertation]. Loyola University Chicago; 2011. [cited 2021 Mar 07]. Available from: https://ecommons.luc.edu/luc_diss/199.

Council of Science Editors:

Larimer KA. Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois. [Doctoral Dissertation]. Loyola University Chicago; 2011. Available from: https://ecommons.luc.edu/luc_diss/199

University of Alberta

14. Hess, Scott L. Depression, Cardiovascular Disease and Amino Acids.

Degree: PhD, Department of Psychiatry, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/4b29b664s

► Major depression (MD) is one of the most prominent medical conditions worldwide in terms of societal cost and morbidity. MD has been associated with increased… (more)

▼ Major depression (MD) is one of the most prominent medical conditions worldwide in terms of societal cost and morbidity. MD has been associated with increased risk for cardiovascular disease (CVD) and conversely CVD has been associated with increased MD symptoms. Previous studies have shown that serum levels of nitric oxide (NO) were reduced in MD patients and in patients with CVD. We measured serum levels of arginine, the precursor amino acid of NO and found that they were reduced in MD subjects compared to healthy controls (HCs). Similarly, levels of citrulline, an amino acid formed during the formation of NO from arginine, were reduced. These results suggest that reduced levels of arginine may be contributing to the reduced NO observed in MD subjects. Dysfunction of the arteries has been identified as a precursor of CVD risk and has been proposed to be related to decreased NO. We hypothesized that endothelium function would be impaired in MD patients compared to HCs. Endothelial function was examined but no differences were observed between the two groups. It may be the case that despite risk of CVD being increased in MD patients, impaired endothelial dysfunction may not be observable. A variety of other amino acids proposed to be important in neurotransmission and the etiology of MD were measured in a population of unmedicated MD subjects and HCs matched for age, sex, dietary intake and lipid profiles; smokers and obese subjects were not included (similar conditions applied in the two studies mentioned above). Cysteine and histidine levels were elevated in the MD group. When male MD subjects were compared to their corresponding controls, the decreases in levels of arginine and citrulline were present, as was the increase in levels of cysteine, but levels of taurine, aspartate, glutamine and tryptophan were also significantly lower in MD subjects. In contrast, when female MD subjects were compared with their corresponding HCs, the differences were not significant. These results emphasize the importance of studying both male and female subjects and their corresponding controls when conducting such biomarker studies.

Subjects/Keywords: Cardiovascular Disease; Major Depression

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APA (6^th Edition):

Hess, S. L. (2014). Depression, Cardiovascular Disease and Amino Acids. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/4b29b664s

Chicago Manual of Style (16^th Edition):

Hess, Scott L. “Depression, Cardiovascular Disease and Amino Acids.” 2014. Doctoral Dissertation, University of Alberta. Accessed March 07, 2021. https://era.library.ualberta.ca/files/4b29b664s.

MLA Handbook (7^th Edition):

Hess, Scott L. “Depression, Cardiovascular Disease and Amino Acids.” 2014. Web. 07 Mar 2021.

Vancouver:

Hess SL. Depression, Cardiovascular Disease and Amino Acids. [Internet] [Doctoral dissertation]. University of Alberta; 2014. [cited 2021 Mar 07]. Available from: https://era.library.ualberta.ca/files/4b29b664s.

Council of Science Editors:

Hess SL. Depression, Cardiovascular Disease and Amino Acids. [Doctoral Dissertation]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/4b29b664s

15. Bournele, Despina. Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο.

Degree: 2016, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/38345

► Cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels and one of the leading causes of death worldwide. The most… (more)

▼ Cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels and one of the leading causes of death worldwide. The most significant risk factors associated with the development of heart diseases include genetic and environmental factors such as hypertension, high blood cholesterol levels, diabetes, smoking, and obesity. Coronary artery disease and stroke account for the highest percentage of CVD deaths and stroke, cardiomyopathies, congenital heart diseases, heart valve defects and arrhythmias follow. The causes, prevention, and treatment of all forms of cardiovascular disease remain active fields of biomedical research, with hundreds of scientific studies published on a weekly basis.Cardiac valves develop as the heart contracts, and they function throughout the lifetime of the organism to prevent retrograde blood flow. Their precise morphogenesis is crucial for cardiac function and depends on the interaction between cardiac contractility and intracardiac flow dynamics. Multiple signaling pathways are implicated in the morphogenesis of cardiac valves but little is known about the molecular mechanisms that orchestrate their formation.Several unique characteristics make zebrafish an attractive model for elucidating the mechanisms underlying cardiac valve morphogeneis. Non-invasive imaging allows in vivo analyses of cardiovascular phenotypes. In addition, zebrafish hearts maintain their ability to regenerate throughout their lifetime, providing novel insights to understand human cardiac regeneration. Zebrafish has also emerged as a high-throughput but low-cost model organism that combines the advantages of forward and reverse genetics with phenotype-driven drug screenings. Functional verification of candidate genes from Genome Wide Association Studies (GWAS) has verified the role of several genes in the pathophysiology of CVDs. Zebrafish is a valuable tool for the identification of candidate genes for congenital heart defects, either through mutant characterization from genetic screens or functional annotation through morphant analysis.Here we describe the identification and the characterization of genes involved in cardiac valve formation. The mutant lines that were used have derived from a forward mutagenesis genetic screen that was carried out in order to identify mutant phenotypes relevant to various aspects of cardiac development. Bua mutant embryos show an outflow tract stenosis phenotype, which results to abnormal atrioventricular valve formation and retrograde blood flow. BH mutants have smaller heart, body axis and head compared to wild-type embryos and have also curved tail.In parallel, we carried out the characterization of a new transgenic line for the wnt/b-catenin signaling pathway. Apc mutant embryos which show constitutive active wnt/b-catenin signaling have also been used for the elaborate characterization of the Tg(7xTCF-Xla.Siam:nlsmCherry) transgenic line.The goal of this research project was the study of gene function, the identification of new signaling pathways and the…

Subjects/Keywords: Συγγενείς καρδιοπάθειες; Cardiovascular disease; Zebrafish

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APA (6^th Edition):

Bournele, D. (2016). Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/38345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bournele, Despina. “Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο.” 2016. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 07, 2021. http://hdl.handle.net/10442/hedi/38345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bournele, Despina. “Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο.” 2016. Web. 07 Mar 2021.

Vancouver:

Bournele D. Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10442/hedi/38345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bournele D. Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. Available from: http://hdl.handle.net/10442/hedi/38345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

16. Ghahramany, Ghazal. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women.

Degree: PhD, Nutrition, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733

► About half of all deaths in developed countries are caused by cardiovascular disease. It is well known that cardiovascular disease (CVD) risk can be influenced… (more)

▼ About half of all deaths in developed countries are caused by cardiovascular disease. It is well known that cardiovascular disease (CVD) risk can be influenced by diet, but optimal dietary content of fatty acids continues to be debated. The effect of fatty acid composition of ground beef on selected cardiovascular disease risk indicators was evaluated with two primary goals. The first goal was to document effects of ground beef fatty acid composition on plasma lipoprotein concentrations, whereas the second goal was to determine the effects of ground beef fatty acid composition on gene expression in peripheral blood mononuclear cells (PBMC). In both studies the results were compared between men and women. Twelve men and women over age of 45 out of initially 15 completed a two-way crossover design. Subjects consumed five, 114-g ground beef patties per week for 5-wk periods separated by a 3-wk washout period. Patties contained on average 20% fat and monounsaturated fatty acid (MUFA): saturated fatty acid (SFA) of 0.8 and 1.1 for low- MUFA (conventional) ground beef high-MUFA (premium) ground beef patties, respectively. Blood was collected from each subject before and at the end of each diet period. Overall, the ground beef interventions decreased total plasma cholesterol, triacylglycerol, and very low density lipoprotein (VLDL) cholesterol. Plasma concentrations of high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol decreased and increased, respectively with premium ground beef consumption. The change in HDL cholesterol was significant in women but not in men suggesting that premium ground beef consumption had a greater impact on women than in men. For the second goal PBMC were isolated and the expression of selected genes was quantified by real-time PCR. ATP-binding cassette A1, ATP-binding cassette G1, and low-density lipoprotein receptor relative expression was increased with premium ground beef consumption. A significant increase was seen in stearoyl-Coenzyme-A desaturase 1 expression after premium ground beef treatment. With the exception of stearoyl-Coenzyme-A desaturase 1, all these genes were down-regulated with conventional ground beef consumption. Both sterol regulatory element binding transcription factor 1 and mediator complex subunit 1 were down-regulated after each beef patty treatment, but the effect was significant after consuming conventional ground beef. This suggests that genes involved in cholesterol metabolism were down-regulated with conventional ground beef consumption; whereas genes related to lipogenesis were up-regulated with premium ground beef consumption. From these data we concluded that different ground beef dietary interventions have different impacts on the PBMC gene expression that is related to cholesterol metabolism, inflammation and liver X receptor pathways. Advisors/Committee Members: Smith, Stephen B. (advisor), Riechman, Steven E. (committee member), Villalobos, Alice (committee member), Wu, Chaodong (committee member).

Subjects/Keywords: cardiovascular disease; Oleic acid; MUFA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ghahramany, G. (2012). High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733

Chicago Manual of Style (16^th Edition):

Ghahramany, Ghazal. “High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women.” 2012. Doctoral Dissertation, Texas A&M University. Accessed March 07, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733.

MLA Handbook (7^th Edition):

Ghahramany, Ghazal. “High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women.” 2012. Web. 07 Mar 2021.

Vancouver:

Ghahramany G. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women. [Internet] [Doctoral dissertation]. Texas A&M University; 2012. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733.

Council of Science Editors:

Ghahramany G. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women. [Doctoral Dissertation]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733

Penn State University

17. Colaco, Brendon. Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample .

Degree: 2011, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/12312

► Cardiovascular diseases are a complex set of diseases that affect the cardiovascular system and have fatal consequences if not identified and treated. There have been… (more)

Subjects/Keywords: MESA; Subclinical Cardiovascular Disease; Predictors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Colaco, B. (2011). Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample . (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/12312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Colaco, Brendon. “Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample .” 2011. Thesis, Penn State University. Accessed March 07, 2021. https://submit-etda.libraries.psu.edu/catalog/12312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Colaco, Brendon. “Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample .” 2011. Web. 07 Mar 2021.

Vancouver:

Colaco B. Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample . [Internet] [Thesis]. Penn State University; 2011. [cited 2021 Mar 07]. Available from: https://submit-etda.libraries.psu.edu/catalog/12312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Colaco B. Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample . [Thesis]. Penn State University; 2011. Available from: https://submit-etda.libraries.psu.edu/catalog/12312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

18. Koschel, Alison. Secondary prevention of cardiovascular disease in an Australian population.

Degree: PhD, 2011, University of Newcastle

URL: http://hdl.handle.net/1959.13/928185

►

Research Doctorate - Doctor of Philosophy (PhD)

Chapter one presents an overview of Coronary Heart Disease, Ischaemic Stroke and Secondary Prevention. A definition of disease… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Chapter one presents an overview of Coronary Heart Disease, Ischaemic Stroke and Secondary Prevention. A definition of disease and recurrent events addressed in this thesis is supplied along with the burden of disease in a local context which is compared to National and International burden of disease figures. Given the focus of this thesis is secondary prevention, modifiable risk factors for CHD and Stroke are identified and discussed in terms of their ability to modify CHD and Stroke if prevented. Proportions of risk factors nationally and internationally are presented to give a picture of the magnitude of the risk associated with CHD and Stroke. Management of risk factors in terms of primary and secondary prevention are presented with an emphasis on available guidelines. Proportions of secondary prevention management at national and international level are presented which highlight a gap in care which gives rise to the aim of this thesis. Chapter two explores in the Hunter region the prevalence of risk factors and secondary prevention care in a sample of patients following discharge from hospital for either a CHD or Stroke event. The chapter concludes that there is room for improvement in this population for risk factor management in patients who have had a prior CVD event. Chapter three describes in detail a randomised controlled trial designed to intervene with patients with existing CVD, the Prevent Another Vascular Event (PAVE) study. The chapter provides evidence of the suitability of using General Practitioners as deliverers of care and outlines the methods used in the factorial design which hypothesized an increase in risk factor management in a patient only group, a GP only group, a GP and patient intervention group compared to a usual care control group. The chapter presents recruitment and baseline risk factor prevalence results which are then compared to National and International study data. Chapter four presents results in relation to the pharmaceutical interventions for risk factors such as high blood pressure, high cholesterol and Atrial Fibrillation. Additionally this chapter discusses the use of Aspirin and advice to take Aspirin as an outcome. Chapter five focuses on the results relevant to behavioural risk factor modification such as advice to increase physical activity, increase smoking cessation and advice to follow a modified fat diet. Finally chapter six presents a summary of the findings and the future directions for research and practice.

Advisors/Committee Members: University of Newcastle. Faculty of Health, School of Medical Practice and Population Health.

Subjects/Keywords: secondary prevention; cardiovascular disease; Australia

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APA (6^th Edition):

Koschel, A. (2011). Secondary prevention of cardiovascular disease in an Australian population. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/928185

Chicago Manual of Style (16^th Edition):

Koschel, Alison. “Secondary prevention of cardiovascular disease in an Australian population.” 2011. Doctoral Dissertation, University of Newcastle. Accessed March 07, 2021. http://hdl.handle.net/1959.13/928185.

MLA Handbook (7^th Edition):

Koschel, Alison. “Secondary prevention of cardiovascular disease in an Australian population.” 2011. Web. 07 Mar 2021.

Vancouver:

Koschel A. Secondary prevention of cardiovascular disease in an Australian population. [Internet] [Doctoral dissertation]. University of Newcastle; 2011. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1959.13/928185.

Council of Science Editors:

Koschel A. Secondary prevention of cardiovascular disease in an Australian population. [Doctoral Dissertation]. University of Newcastle; 2011. Available from: http://hdl.handle.net/1959.13/928185

19. Maan, Abhishek. Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the.

Degree: School of Public Health, 2018, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:792665/

► The United States Preventive Services Task Force (USPSTF) recommends aspirin for primary prevention of coronary artery disease (CAD) in adults aged 50-69 years. The objective… (more)

Subjects/Keywords: Aspirin; cardiovascular disease; atrial fibrillation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maan, A. (2018). Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792665/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maan, Abhishek. “Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the.” 2018. Thesis, Brown University. Accessed March 07, 2021. https://repository.library.brown.edu/studio/item/bdr:792665/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maan, Abhishek. “Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the.” 2018. Web. 07 Mar 2021.

Vancouver:

Maan A. Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Mar 07]. Available from: https://repository.library.brown.edu/studio/item/bdr:792665/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maan A. Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792665/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

20. Glendenning, Cate. CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME.

Degree: 2016, Wake Forest University

URL: http://hdl.handle.net/10339/64188

ABSTRACT

Subjects/Keywords: Cardiovascular disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Glendenning, C. (2016). CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/64188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Glendenning, Cate. “CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME.” 2016. Thesis, Wake Forest University. Accessed March 07, 2021. http://hdl.handle.net/10339/64188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Glendenning, Cate. “CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME.” 2016. Web. 07 Mar 2021.

Vancouver:

Glendenning C. CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME. [Internet] [Thesis]. Wake Forest University; 2016. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/10339/64188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Glendenning C. CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME. [Thesis]. Wake Forest University; 2016. Available from: http://hdl.handle.net/10339/64188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

21. Govender, Preesha. Cardiovascular disease profile in patients with established rheumatoid arthritis at King Edward VIII Hospital.

Degree: 2018, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/18003

► Rheumatoid arthritis (RA) is one of the most common chronic systemic autoimmune inflammatory diseases, which is associated with an increased mortality rate, attributed to premature… (more)

▼ Rheumatoid arthritis (RA) is one of the most common chronic systemic autoimmune inflammatory diseases, which is associated with an increased mortality rate, attributed to premature cardiovascular disease (CVD). Key drivers of mortality from CVD in RA are fuelled by multiple factors. Rheumatoid arthritis disease profiling, particularly seropositivity, presence of extra-articular disease and high disease activity, confer an increased mortality risk. Traditional CVD risk factors (hypertension, diabetes mellitus, dyslipidaemia, obesity) are influenced by both inflammation inherent to RA, and pharmacodynamics of anti-rheumatic drugs. Notwithstanding the above, the current paradigm shift recognises RA as an independent risk factor for CVD. Similar to the rest of Africa, local data on the prevalence of CVD in RA are limited. With an increase in non-communicable diseases and longevity, the RA burden in South Africa (SA) is expected to increase. Local studies are needed to stratify practice in cardio-protective strategies and improved long term outcomes in RA. This study aims to determine the prevalence of CVD in RA, describe the prevalence of CVD risk factors in RA and describe the relationship between RA disease activity and CVD. A retrospective, chart review of all patients with RA according to the American College of Rheumatology 1987/2010 Classification criteria, attending the arthritis clinic in King Edward VIII hospital, a tertiary public healthcare academic teaching hospital in KwaZulu-Natal, SA, during the period August 2017 to March 2018, was undertaken. Patients younger than 18 years of age, or with RA and any other concomitant connective tissue disease or overlap syndrome were excluded. The study group included 150 patients with RA. The demographic details, duration of the RA disease, traditional CVD risk factors, simplified disease activity index (SDAI) and health assessment questionnaire (HAQ) were documented. In addition, results of electrocardiogram, echocardiogram, haemoglobin, glycated haemoglobin, lipid studies and estimated glomerular filtration rate were recorded. Cardiovascular disease was found in 16% of the total study cohort, with an age, gender and ethnic differential. Coronary artery disease was the most common CVD finding in RA patients. The burden of traditional CVD risk factors in RA is high, with hypertension, diabetes mellitus, dyslipidaemia, physical inactivity and chronic kidney disease of particular concern. No significant correlation was observed between RA disease activity, seropositivity and CVD in RA however, extra-articular disease was more common among patients with CVD. Echocardiographic evidence of subclinical cardiac disease in RA is common. Significant disparity was observed between various CVD risk assessment models at different levels of risk, which cautions a comprehensive CVD risk assessment model that stratifies discriminately is needed in patients with RA. The study provides knowledge of CVD burden and risk in RA patients locally, and serves as a foundation for further… Advisors/Committee Members: Paruk, Farhanah. (advisor).

Subjects/Keywords: Rheumatoid arthritis.; Cardiovascular disease.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Govender, P. (2018). Cardiovascular disease profile in patients with established rheumatoid arthritis at King Edward VIII Hospital. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/18003

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Govender, Preesha. “Cardiovascular disease profile in patients with established rheumatoid arthritis at King Edward VIII Hospital.” 2018. Thesis, University of KwaZulu-Natal. Accessed March 07, 2021. https://researchspace.ukzn.ac.za/handle/10413/18003.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Govender, Preesha. “Cardiovascular disease profile in patients with established rheumatoid arthritis at King Edward VIII Hospital.” 2018. Web. 07 Mar 2021.

Vancouver:

Govender P. Cardiovascular disease profile in patients with established rheumatoid arthritis at King Edward VIII Hospital. [Internet] [Thesis]. University of KwaZulu-Natal; 2018. [cited 2021 Mar 07]. Available from: https://researchspace.ukzn.ac.za/handle/10413/18003.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Govender P. Cardiovascular disease profile in patients with established rheumatoid arthritis at King Edward VIII Hospital. [Thesis]. University of KwaZulu-Natal; 2018. Available from: https://researchspace.ukzn.ac.za/handle/10413/18003

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

22. Moore, Patricia Sinclair. Depressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparison.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1356

► While rates of depression are similar across ethnic groups, severity of symptoms and disability related to depression are greater in African Americans when compared with… (more)

Subjects/Keywords: Cardiovascular Disease; Depression; African Americans

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APA (6^th Edition):

Moore, P. S. (2013). Depressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparison. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moore, Patricia Sinclair. “Depressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparison.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed March 07, 2021. http://hdl.handle.net/2152.5/1356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moore, Patricia Sinclair. “Depressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparison.” 2013. Web. 07 Mar 2021.

Vancouver:

Moore PS. Depressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparison. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/2152.5/1356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moore PS. Depressive Symptoms and Subclinical Vascular Disease: A Cross-Cultural Comparison. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

23. Alibhai, Faisal. The Critical Role of Circadian Rhythms in the Pathophysiology of Cardiovascular Disease.

Degree: PhD, Department of Biomedical Sciences, 2016, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10054

► Cardiovascular physiology exhibits circadian rhythms in number of parameters including heart rate, blood pressure, and myocardial contractility. Disruption of circadian rhythms alters cardiovascular rhythms and… (more)

▼ Cardiovascular physiology exhibits circadian rhythms in number of parameters including heart rate, blood pressure, and myocardial contractility. Disruption of circadian rhythms alters cardiovascular rhythms and increases the risk of cardiovascular disease. However, the pathophysiological mechanisms responsible are poorly understood. This thesis investigates the role of circadian rhythms in the pathophysiology of cardiovascular disease. Study 1 demonstrates that short term circadian rhythm disruption following myocardial infarction alters the inflammatory response post-myocardial infarction. Although rhythms were only disturbed for 5 days, disruption impaired scar formation and worsened long-term outcome. Maintenance of rhythms facilitated proper infarct healing and better outcome. The circadian mechanism factor CLOCK plays a key role in regulating inflammatory responses as ClockΔ19/Δ19 mice (which lack a functional circadian mechanism) exhibit increased macrophage infiltration post-myocardial infarction. This has important implications for patients recovering in intensive care units where circadian rhythm disturbances are common. Study 2 shows that male ClockΔ19/Δ19 mice develop age-dependent cardiovascular disease characterized by cardiac hypertrophy, fibrosis, impaired vascular responses, and reduced cardiac function. Development of disease in ClockΔ19/Δ19 mice is associated with increased activation of AKT and mTOR signalling. Pharmacological modulation of the circadian mechanism reduced AKT activation and heart weight in a Clock-dependent manner. These results support CLOCK as a regulator of cardiac growth and suggest that pharmacological modulation of the circadian mechanism is a novel approach for treating cardiovascular disease. Study 3 shows that female ClockΔ19/Δ19 mice are protected from the development of age-dependent heart disease. In contrast to the males, female ClockΔ19/Δ19 mice maintain normal heart size with age. Although CLOCK disruption altered diurnal activity and food intake, female ClockΔ19/Δ19 mice maintain normal glucose tolerance as well as normal cardiac and liver substrate uptake. Further examination of cardiac metabolism shows that female ClockΔ19/Δ19 hearts have altered lipid profiles compared to male mice, which may limit myocyte loss and preserve mitochondrial function with age. Lastly, a protective role for ovarian hormones is shown as ovariectomized ClockΔ19/Δ19 mice develop increased LV dilation compared to ovariectomized WT mice by 8 months. Collectively these studies demonstrate novel and important roles of circadian rhythms in the pathophysiology of cardiovascular disease. Advisors/Committee Members: Martino, Tami (advisor).

Subjects/Keywords: Cardiovascular Disease; Circadian Rhythms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alibhai, F. (2016). The Critical Role of Circadian Rhythms in the Pathophysiology of Cardiovascular Disease. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10054

Chicago Manual of Style (16^th Edition):

Alibhai, Faisal. “The Critical Role of Circadian Rhythms in the Pathophysiology of Cardiovascular Disease.” 2016. Doctoral Dissertation, University of Guelph. Accessed March 07, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10054.

MLA Handbook (7^th Edition):

Alibhai, Faisal. “The Critical Role of Circadian Rhythms in the Pathophysiology of Cardiovascular Disease.” 2016. Web. 07 Mar 2021.

Vancouver:

Alibhai F. The Critical Role of Circadian Rhythms in the Pathophysiology of Cardiovascular Disease. [Internet] [Doctoral dissertation]. University of Guelph; 2016. [cited 2021 Mar 07]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10054.

Council of Science Editors:

Alibhai F. The Critical Role of Circadian Rhythms in the Pathophysiology of Cardiovascular Disease. [Doctoral Dissertation]. University of Guelph; 2016. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/10054

University of Cambridge

24. Shahzad, Sara. Diet and risk of acute myocardial infarction in Bangladesh: The Bangladesh Risk of Acute Vascular Events (BRAVE) study.

Degree: PhD, 2020, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/298859

► SUMMARY Name: Sara Shahzad Title: Diet and risk of acute myocardial infarction in Bangladesh: the Bangladesh Risk of Acute Vascular Events (BRAVE) study Background Coronary… (more)

▼ SUMMARY Name: Sara Shahzad Title: Diet and risk of acute myocardial infarction in Bangladesh: the Bangladesh Risk of Acute Vascular Events (BRAVE) study Background Coronary Heart Disease (CHD), with myocardial infarction (MI) as its main manifestation, is increasing at an alarming rate in South Asian countries, however evidence on its determinants is sparse. Dietary risk explains about one-third of global mortality and is a most important modifiable risk factor for CHD. Although there is extensive evidence on diet and risk of CHD from western populations, this cannot be generalised to South Asian populations where the dietary habits are very diverse. Objectives: The main aims of this thesis are to (1) summarise existing epidemiological evidence on diet and risk of CHD in South Asians; (2) characterise in detail the lifestyle socio-demographic and other correlates of dietary factors in a South Asian population; (3) investigate the association of dietary food groups, patterns and nutrients with the risk of MI and (4) discuss public health implications of the findings. Methods: BRAVE is a hospital-based case-control study from Dhaka, Bangladesh which has about 8000 cases and 8000 controls frequency matched by age and sex. This study has overlapping data looking at lifestyle (including dietary determinants), biochemical, genetic and environmental risk factors for acute MI (AMI). Using data from this study dietary determinants of AMI were investigated through (1) cross-sectional analyses of the association of diet with various correlates and (2) case-control analyses with risk of MI. Results: The systematic review demonstrated that there was scarce evidence on diet and risk of CHD from South Asia. Cross-sectional analyses from BRAVE study demonstrated that dietary food groups, patterns and nutrients had different associations with the various characteristics showing the role of modest confounding. There were few strong correlations between food groups, nutrients and dietary patterns. Findings from food group analyses showed an inverse association between fruits, vegetables, yoghurt, certain spices and risk of AMI. In contrast, higher consumption of biryani and fish was associated with higher risk of AMI. Three distinct dietary patterns were identified using principal component analysis; the “energy dense pattern”, the “vegetable pattern” and the “fruits and dairy pattern”. The vegetable pattern and fruit and dairy pattern had an inverse association with the risk of AMI. In contrast, “energy dense pattern” had no significant association with the risk of AMI. As for the analyses on dietary nutrients, higher intake of refined carbohydrates was not associated with the risk of AMI, while non-refined carbohydrates were associated with lower risk of AMI. Animal protein showed a higher risk of AMI, whereas plant protein showed a weak inverse association. As for specific fatty acids, modest intakes of saturated fatty acid from dairy sources and polyunsaturated fatty acids were associated with a slightly lower risk of AMI.…

Subjects/Keywords: Diet; Cardiovascular disease; South Asians

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shahzad, S. (2020). Diet and risk of acute myocardial infarction in Bangladesh: The Bangladesh Risk of Acute Vascular Events (BRAVE) study. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/298859

Chicago Manual of Style (16^th Edition):

Shahzad, Sara. “Diet and risk of acute myocardial infarction in Bangladesh: The Bangladesh Risk of Acute Vascular Events (BRAVE) study.” 2020. Doctoral Dissertation, University of Cambridge. Accessed March 07, 2021. https://www.repository.cam.ac.uk/handle/1810/298859.

MLA Handbook (7^th Edition):

Shahzad, Sara. “Diet and risk of acute myocardial infarction in Bangladesh: The Bangladesh Risk of Acute Vascular Events (BRAVE) study.” 2020. Web. 07 Mar 2021.

Vancouver:

Shahzad S. Diet and risk of acute myocardial infarction in Bangladesh: The Bangladesh Risk of Acute Vascular Events (BRAVE) study. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Mar 07]. Available from: https://www.repository.cam.ac.uk/handle/1810/298859.

Council of Science Editors:

Shahzad S. Diet and risk of acute myocardial infarction in Bangladesh: The Bangladesh Risk of Acute Vascular Events (BRAVE) study. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://www.repository.cam.ac.uk/handle/1810/298859

University of Manitoba

25. Boreskie, Kevin. Examining frailty and cardiovascular disease risk profile in middle-aged and older women.

Degree: Kinesiology and Recreation Management, 2018, University of Manitoba

URL: http://hdl.handle.net/1993/33416

► Frailty assessment has been suggested to improve cardiovascular disease (CVD) risk management. Frailty is characterized as having a lack of reserve for tolerating health stressors.… (more)

Subjects/Keywords: Cardiovascular disease; Frailty; Screening; Women

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APA (6^th Edition):

Boreskie, K. (2018). Examining frailty and cardiovascular disease risk profile in middle-aged and older women. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/33416

Chicago Manual of Style (16^th Edition):

Boreskie, Kevin. “Examining frailty and cardiovascular disease risk profile in middle-aged and older women.” 2018. Masters Thesis, University of Manitoba. Accessed March 07, 2021. http://hdl.handle.net/1993/33416.

MLA Handbook (7^th Edition):

Boreskie, Kevin. “Examining frailty and cardiovascular disease risk profile in middle-aged and older women.” 2018. Web. 07 Mar 2021.

Vancouver:

Boreskie K. Examining frailty and cardiovascular disease risk profile in middle-aged and older women. [Internet] [Masters thesis]. University of Manitoba; 2018. [cited 2021 Mar 07]. Available from: http://hdl.handle.net/1993/33416.

Council of Science Editors:

Boreskie K. Examining frailty and cardiovascular disease risk profile in middle-aged and older women. [Masters Thesis]. University of Manitoba; 2018. Available from: http://hdl.handle.net/1993/33416

University of Oxford

26. Patel, Jyoti. The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis.

Degree: PhD, 2011, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814

► Chemokine-induced macrophage recruitment into the vascular wall is an early pathological event in the progression of atherosclerosis. Macrophage activation and chemotaxis during cell recruitment are… (more)

▼ Chemokine-induced macrophage recruitment into the vascular wall is an early pathological event in the progression of atherosclerosis. Macrophage activation and chemotaxis during cell recruitment are mediated by chemokine ligation of multiple G-protein coupled receptors. The Regulator of G-Protein Signalling-1 (RGS-1) acts to down-regulate the response to sustained chemokine stimulation. Studies in this laboratory have shown Rgs1 is up-regulated in atherosclerotic ApoE^-/- mice in association with atherosclerotic plaque progression and published findings have reported that RGS1 is highly expressed in leukocytes. However an in vivo role for RGS-1 in macrophage function or in atherosclerosis has not been investigated. This thesis aimed to address the hypothesis that RGS1 has an important role in atherosclerosis and modulates the inflammatory response by controlling chemokine signalling and macrophage chemotaxis to atherosclerotic plaques. To investigate the role of RGS1 in macrophage function and the development of atherosclerosis, Rgs1^-/- mice were characterised on the ApoE^-/- background. Flow cytometric analysis of leukocytes in blood, spleen and bone marrow indicated Rgs1^-/-ApoE^-/- mice had no significant differences in the numbers of monocytes or lymphocytes compared to ApoE^-/- mice. Rgs1 was found to be highly expressed in macrophages from ApoE^-/- mice compared to B-lymphocytes, where it has a non-redundant role, and other cells involved in plaque formation. Furthermore, Rgs1 is up-regulated with monocyte-macrophage activation by innate stimuli. For the first time, RGS1 was shown to affect chemokine receptor signalling in macrophages in vitro. Rgs1^-/-ApoE^-/- macrophages showed significantly enhanced chemotaxis to CCL2, CCL3 and CCL5 and impaired homologous desensitisation to the chemokine CCL5 in comparison to ApoE^-/- cells. To determine the role of RGS-1 in leukocyte trafficking and atherosclerosis, a detailed atherosclerosis study was carried out. Rgs1^-/-ApoE^-/- mice had significantly less lesion formation in the aortic roots at 9-weeks and in the aorta at 16-weeks on a chow diet in comparison to ApoE^-/- mice. This was accompanied with decreased macrophage content in the aortic root at 9-weeks. To further investigate aortic leukocyte recruitment, an Angiotensin II-induced model of acute vascular inflammation was used. At 9 weeks of age, Rgs1^-/-ApoE^-/- mice had significantly less aortic CD45⁺ leukocytes and CD11b⁺ myeloid cells recruited to the aorta in comparison to ApoE^-/- mice. Collectively, these findings identify a new role for RGS-1 in macrophage function and support a role for RGS-1 in leukocyte recruitment and retention in the initial stages of atherosclerotic plaque formation. These results identify RGS1 as a novel target for the treatment of acute vascular inflammation and early atherosclerosis.

Subjects/Keywords: 616.136; Immunology; Cardiovascular disease

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APA (6^th Edition):

Patel, J. (2011). The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814

Chicago Manual of Style (16^th Edition):

Patel, Jyoti. “The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis.” 2011. Doctoral Dissertation, University of Oxford. Accessed March 07, 2021. http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814.

MLA Handbook (7^th Edition):

Patel, Jyoti. “The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis.” 2011. Web. 07 Mar 2021.

Vancouver:

Patel J. The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis. [Internet] [Doctoral dissertation]. University of Oxford; 2011. [cited 2021 Mar 07]. Available from: http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814.

Council of Science Editors:

Patel J. The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis. [Doctoral Dissertation]. University of Oxford; 2011. Available from: http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814

University of Oxford

27. Ferreira, Vanessa Melanie. T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application.

Degree: PhD, 2013, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810

► Cardiovascular magnetic resonance (CMR) is superior to other cardiac imaging modalities in its ability to perform multiparametric myocardial tissue characterisation. Commonly applied techniques include T2-weighted… (more)

▼ Cardiovascular magnetic resonance (CMR) is superior to other cardiac imaging modalities in its ability to perform multiparametric myocardial tissue characterisation. Commonly applied techniques include T2-weighted (T2W) imaging for detecting oedema and late gadolinium contrast enhancement imaging for detecting fibrosis, allowing characterisation of most cardiac conditions encountered in the clinical setting. While these techniques have proven useful, conventional MR images acquired by these techniques are displayed on an arbitrary scale and only semi-quantitative with some inherent deficiencies. Quantitative techniques, such as T1-mapping, allow direct quantification of tissue properties and may circumvent many of the issues of conventional MR imaging, with potential to offer more insight into diseased myocardium. Although T1-mapping has been well-established for brain T1-mapping, cardiac T1-mapping has been slow to mature due to technical and practical challenges. The aim of this thesis was to develop a novel method for cardiac T1-mapping that is robust and clinically applicable so that cardiac T1-mapping can transition from a research tool into clinical practice. Further, cardiac T1-mapping using this new technique was validated in normal and disease states, including its ability to detect regional and global myocardial oedema and acute myocarditis. This work developed a novel MR sequence for cardiac T1-mapping, named Shortened Modified Look-Locker Inversion Recovery (ShMOLLI). The conventional method (MOLLI) required 17 heart-beats (a 17 second breath-hold for a patient with a heart rate of 60 bpm) for the acquisition of one slice of T1-map. This is difficult to achieve for patients, especially those who are acutely ill and if whole heart coverage (~8 slices) were desired. One of the goals in the design of ShMOLLI was to bring the breath-hold time down to below 10 seconds so that patients may tolerate the protocol. The design of ShMOLLI was successful in breaching the 10-second breath-hold time without compromising the accuracy of T1 measurements compared to the conventional method; further, unlike MOLLI, ShMOLLI did not exhibit increasing error with increasing T1 or heart rates, making it advantageous in measuring long T1 values and at fast heart rates. These features of ShMOLLI make it a very attractive method ready for clinical application. The ShMOLLI method was then further applied to disease states, starting with models of acute myocardial oedema. ShMOLLI T1-mapping was performed in patients with acute stress-induced cardiomyopathy (model of global oedema) and in patients with regional oedema without infarction, and compared to T2W imaging. T1-mapping demonstrated an excellent diagnostic performance compared to the T2W methods in detecting acute myocardial oedema, whether it was global or regional. ShMOLLI T1-mapping was well-tolerated by acute cardiac patients and showed promise in its application to other conditions in which oedema would be a major component in the pathophysiology. ShMOLLI T1-mapping was…

Subjects/Keywords: 616.1237075; Cardiovascular disease; Medical Sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferreira, V. M. (2013). T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810

Chicago Manual of Style (16^th Edition):

Ferreira, Vanessa Melanie. “T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application.” 2013. Doctoral Dissertation, University of Oxford. Accessed March 07, 2021. http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810.

MLA Handbook (7^th Edition):

Ferreira, Vanessa Melanie. “T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application.” 2013. Web. 07 Mar 2021.

Vancouver:

Ferreira VM. T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application. [Internet] [Doctoral dissertation]. University of Oxford; 2013. [cited 2021 Mar 07]. Available from: http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810.

Council of Science Editors:

Ferreira VM. T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application. [Doctoral Dissertation]. University of Oxford; 2013. Available from: http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810

University of Oxford

28. Turtle, Cameron William. Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis.

Degree: PhD, 2015, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022

► Mutations in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopathies. However, cardiac disease caused by mutations in non-sarcomeric proteins exhibit remarkably… (more)

▼ Mutations in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopathies. However, cardiac disease caused by mutations in non-sarcomeric proteins exhibit remarkably similar phenotypes, suggesting that common modes of pathogenesis might exist. It is of particular interest whether non-sarcomeric mutations result in impaired contractile function akin to sarcomeric diseases. Accordingly, this thesis describes the effect of cardiomyopathy-causing mutations to an energy sensing protein (AMPK γ2) and a small heat shock protein (αB-crystallin) on cardiac myofilament biomechanics and Ca²⁺ handling. Mutations in the regulatory γ2 subunit of AMP-activated kinase (AMPK), encoded by the PRKAG2 gene, cause a cardiomyopathy characterized by ventricular hypertrophy, electrophysiological abnormalities, and glycogen accumulation. Data from animal models in which the mutant transgene is overexpressed suggest that the electrophysiological aspects might be caused by excess glycogen, but that this is insufficient to account for all facets of the phenotype. A novel knock-in mouse expressing R299Q AMPK γ2 (homologous to the human R302Q mutation) was generated to model PRKAG2 cardiomyopathy more accurately. Assessment of the cardiac phenotype at two months to determine the early events in disease pathogenesis revealed systolic and diastolic dysfunction in mutant animals, with no excess glycogen detected. Analysis of acetyl-CoA carboxylase phosphorylation at S79 suggested increased basal AMPK activity in mutant animals. Increased sarcomeric Ca2+ sensitivity of contractile activation was observed in demembranated cardiac trabeculae from mutant animals, associated with decreased phosphorylation of cardiac troponin I at S23/S24 and increased phosphorylation at S150. Treatment with protein kinase A normalized this difference in Ca2+ sensitivity, suggesting that reduced PKA phosphorylation is the primary abnormality in mutant tissue. Cardiomyocytes from mutant animals exhibited slowed contractile and Ca2+ reuptake rates, associated with reduced phosphorylation of phospholamban and myosin binding protein C, as well as an increased response to isoproterenol. The lack of glycogen accumulation in these animals, combined with abnormal contractile and Ca²⁺ handling properties, reveals a more nuanced interpretation of the mechanism of PRKAG2 cardiomyopathy development. Further, the newly identified interaction between energy- (AMPK) and stress- (PKA) signalling networks may be of importance in numerous additional disease pathways. This thesis clarifies the role of αB-crystallin, and its cardiomyopathy-causing mutant (R157H), in regulating cardiac muscle stiffness. Specifically, mass spectrometry data revealed that αB-crystallin forms large oligomers and binds to titin Ig domains. Nuclear magnetic resonance confirmed this binding and suggested that αB-crystallin's C-terminal is responsible for titin binding. A…

Subjects/Keywords: 616.1; Cardiovascular disease; Cardiomyopathy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Turtle, C. W. (2015). Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022

Chicago Manual of Style (16^th Edition):

Turtle, Cameron William. “Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis.” 2015. Doctoral Dissertation, University of Oxford. Accessed March 07, 2021. http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022.

MLA Handbook (7^th Edition):

Turtle, Cameron William. “Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis.” 2015. Web. 07 Mar 2021.

Vancouver:

Turtle CW. Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis. [Internet] [Doctoral dissertation]. University of Oxford; 2015. [cited 2021 Mar 07]. Available from: http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022.

Council of Science Editors:

Turtle CW. Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis. [Doctoral Dissertation]. University of Oxford; 2015. Available from: http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022

University of Manchester

29. Mirjafari, Hoda. The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort.

Degree: PhD, 2011, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022

► Introduction: Patients with inflammatory polyarthritis (IP) have an excess risk of cardiovascular (CVD) mortality due to accelerated atherosclerosis. Markers identifying individuals with subclinical atherosclerosis as… (more)

▼ Introduction: Patients with inflammatory polyarthritis (IP) have an excess risk of cardiovascular (CVD) mortality due to accelerated atherosclerosis. Markers identifying individuals with subclinical atherosclerosis as measured by carotid intima-medial thickness (cIMT) and plaque may allow for attenuation of CVD risk. The objective of this study was to identify associated risk markers for atheromatous plaque and cIMT in an incident cohort of patients with early IP and to assess the risk markers associated with progression of cIMT and plaque after 2 years of follow-up.Methods: From 2004 to 2008 consecutive patients with early IP (≥2 joints swollen for ≥4 weeks) aged 18-65 years, who were within 24 months of symptom onset (±6 months) were recruited as part of a primary-care-based inception cohort. Apparently healthy controls were recruited on a frequency matched 'buddy' pair system. Patients underwent joint and blood pressure examination. Patients and controls underwent BMI measurement and their medication was recorded. Patients' blood was taken for measurement of rheumatoid factor, anti-citrullinated protein antibody, C reactive protein, glucose, lipids (LDL, HDL, triglycerides, paroxonase 1, apolipoprotein A1 and B) and markers of vascular damage (E-selectin, VCAM) and adipocytokines (leptin and adiponectin). Patients and controls underwent B mode Doppler ultrasound examination of the carotid arteries to assess for cIMT and the presence of plaque. In univariate analyses we identified factors that were associated with cIMT and plaque presence after age and gender adjustment. An additive stepwise multivariable logistic regression model was created to investigate the independence of any associations.Results: The 329 IP subjects had a median (IQR) age of 51 (42-58) years and 96 (29%) were male. IP subjects were more likely to be smokers, have a family history of CVD, have diabetes, higher BP and be overweight than their apparently healthy counterparts. IP subjects with plaque at baseline often did not have prior CVD. Subjects with IP had a 2.87 fold higher plaque frequency at the baseline but a similar median cIMT relative to the controls. Traditional CVD risk markers such as age, systolic BP and LDL were associated with cIMT and plaque at baseline. Adiponectin levels were negatively associated with cIMT and positively associated with plaque. IP subjects had a significant increase in their cIMT in the first 2 years of follow-up. The rate of progression of cIMT was 1.5-2.2 fold greater in IP than reported in the general population. Novel risk factors added to the model above and beyond traditional risk factors in predicting atherosclerosis. Steroid exposure at 2 years was associated with atherosclerosis progression.Conclusion: Markers known to be associated with atherosclerosis in the general population are associated with cIMT and plaque presence in early IP prior to established inflammatory disease and therapy. While cIMT in subjects and controls was the same at baseline there was an accelerated rate of progression of…

Subjects/Keywords: 616.1; Cardiovascular disease; Rheumatoid arthritis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mirjafari, H. (2011). The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022

Chicago Manual of Style (16^th Edition):

Mirjafari, Hoda. “The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort.” 2011. Doctoral Dissertation, University of Manchester. Accessed March 07, 2021. https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022.

MLA Handbook (7^th Edition):

Mirjafari, Hoda. “The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort.” 2011. Web. 07 Mar 2021.

Vancouver:

Mirjafari H. The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2021 Mar 07]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022.

Council of Science Editors:

Mirjafari H. The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort. [Doctoral Dissertation]. University of Manchester; 2011. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022

University of Oxford

30. Dall'Armellina, Erica. Applications of 3 Tesla CMR in acute coronary syndromes (ACS).

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619

► Introduction: There is a pressing clinical need to treat patients with acute coronary syndrome (ACS) timely and efficiently in order to improve their prognosis. Standard… (more)

▼ Introduction: There is a pressing clinical need to treat patients with acute coronary syndrome (ACS) timely and efficiently in order to improve their prognosis. Standard tools available in ED, while useful, do not comprehensively characterize ACS for either diagnosis or risk stratification. The role of CMR in ACS is emerging because it allows assessment of both myocardial composition and function. Newer CMR techniques such as: a) T2 W imaging for assessing myocardial oedema and area at risk B) pre contrast T1 mapping techniques for quantitative characterization of the tissue composition, are adding further utility for CMR in ACS. At present the clinical use of these techniques is still limited and further investigations are needed to assess their clinical applicability in ACS patients. Aims: The aims of this thesis were several. Firstly we sought to establish a CMR protocol for imaging ACS patients on a 3T CMR scanner. In order to do so, we validated a novel T2 W technique for oedema imaging (T2 prep SSFP) at 3T. Second, we aimed to perform a detailed study of the time course of oedema in ACS patients in order to establish the appropriate imaging time for the assessment of area at risk. Third, by applying T2W acute oedema imaging, we sought to investigate the functional and pathological meaning of complicated remote plaques in patients with multivessel disease. Finally, we aimed to establish whether, in comparison to standard CMR techniques, novel precontrast T1 mapping allows better characterization of the acutely injured myocardium and whether it can predict long-term functional recovery. Methods: The research studies were all performed on a 3T Trio Siemens scanner. In the initial stage of the research, we validated the T2 W technique performing phantom work and scanning both volunteers and patients to assess the uniformity of signal intensity in the myocardium and to establish a threshold based method to post process the images. We then established a CMR protocol for ACS including oedema imaging, T1 mapping imaging, perfusion, functional and late gadolinium enhancement imaging. Patients with acute myocardial infarction (both ST elevation myocardial infarction (STEMI) and non STEMI) were scanned at 4 different time points after the acute event (3 scans within 2 weeks and one at 6 months). All STEMI patients underwent primary percutaneous coronary intervention (PCI) while the non-STEMI patients underwent coronary angiography and /or PCI. Results: We validated the T2prep SSFP technique at 3T, highlighting its limitations and establishing a threshold of mean ± 2SD to assess myocardial oedema. We found that the optimal imaging window to assess the maximal expression of myocardial oedema was within 1 week from the acute event in patients with ST elevation MI. Also, our results showed a reduction of LGE over time (from acute to chronic) in segments which also showed improvement in contractile function indicating that even segments with transmural LGE assessed in the early hours post event could be viable. By applying…

Subjects/Keywords: 616.123; Cardiovascular disease; Medical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dall'Armellina, E. (2012). Applications of 3 Tesla CMR in acute coronary syndromes (ACS). (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619

Chicago Manual of Style (16^th Edition):

Dall'Armellina, Erica. “Applications of 3 Tesla CMR in acute coronary syndromes (ACS).” 2012. Doctoral Dissertation, University of Oxford. Accessed March 07, 2021. http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619.

MLA Handbook (7^th Edition):

Dall'Armellina, Erica. “Applications of 3 Tesla CMR in acute coronary syndromes (ACS).” 2012. Web. 07 Mar 2021.

Vancouver:

Dall'Armellina E. Applications of 3 Tesla CMR in acute coronary syndromes (ACS). [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2021 Mar 07]. Available from: http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619.

Council of Science Editors:

Dall'Armellina E. Applications of 3 Tesla CMR in acute coronary syndromes (ACS). [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619

Open Access Theses and Dissertations