subject:( Cardiovascular disease)

Anna University

1. Jamuna devi A. Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;.

Degree: Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach, 2015, Anna University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/35496

►

Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach newline newlineCardiovascular disease is the leading cause of death… (more)

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

A, J. d. (2015). Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;. (Thesis). Anna University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/35496

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

A, Jamuna devi. “Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;.” 2015. Thesis, Anna University. Accessed November 12, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/35496.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

A, Jamuna devi. “Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;.” 2015. Web. 12 Nov 2019.

Vancouver:

A Jd. Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;. [Internet] [Thesis]. Anna University; 2015. [cited 2019 Nov 12]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35496.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

A Jd. Hypolipidemic action of ambrex an amber based herbal formulation an in vivo and in vitro approach;. [Thesis]. Anna University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35496

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

2. Goldman, Matthew Patrick. Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis.

Degree: 2018, Wake Forest University

URL: http://hdl.handle.net/10339/93046

► Peripheral arterial disease (PAD) is a progressive disease that affects up to 10% of the population worldwide. The burden of this disease on individuals, health… (more)

Subjects/Keywords: Cardiovascular Disease

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APA (6^th Edition):

Goldman, M. P. (2018). Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/93046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Goldman, Matthew Patrick. “Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis.” 2018. Thesis, Wake Forest University. Accessed November 12, 2019. http://hdl.handle.net/10339/93046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Goldman, Matthew Patrick. “Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis.” 2018. Web. 12 Nov 2019.

Vancouver:

Goldman MP. Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis. [Internet] [Thesis]. Wake Forest University; 2018. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10339/93046.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Goldman MP. Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis. [Thesis]. Wake Forest University; 2018. Available from: http://hdl.handle.net/10339/93046

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

3. Azeem, Amir. Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/39023

► In this thesis, we will seek to evaluate the role of a biomarker, hemoglobin A1c, as a predictor of incident cardiovascular disease and all-cause mortality… (more)

Subjects/Keywords: Cardiovascular Disease

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APA (6^th Edition):

Azeem, A. (2013). Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/39023

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Azeem, Amir. “Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality.” 2013. Thesis, Wake Forest University. Accessed November 12, 2019. http://hdl.handle.net/10339/39023.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Azeem, Amir. “Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality.” 2013. Web. 12 Nov 2019.

Vancouver:

Azeem A. Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10339/39023.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Azeem A. Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/39023

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Aslibekyan, Stella. Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study.

Degree: PhD, Epidemiology, 2011, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:11241/

► Abstract of Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study, by Stella Aslibekyan, Ph.D., Brown University, May 2011Cardiovascular disease is… (more)

▼ Abstract of Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study, by Stella Aslibekyan, Ph.D., Brown University, May 2011Cardiovascular disease is the leading cause of death, disability, and healthcare expenses throughout the world, including low- and middle-income countries. However, the gap in cardiovascular epidemiology research between the developed and the developing worlds remains substantial. This dissertation aims to elucidate the role that genetic and environmental predictors play in the etiology of nonfatal myocardial infarction in a population of Costa Rican adults undergoing nutritional transition. In the first chapter, we developed and validated the first cardiovascular risk score to be exclusively based on lifestyle predictors and derived in a non-Western population. Our score presents a simple, low-cost alternative to the existing measures of cardiovascular risk stratification in resource-limited settings. In the second and third chapters, we investigated potential associations between genetic variation in desaturases and elongases, polyunsaturated fatty acid metabolism, and the risk of heart disease among Costa Rican adults. Our findings showed robust associations between six common single nucleotide polymorphisms in the desaturase genes and adipose tissue polyunsaturated fatty acids, as well as serum triglycerides and C-reactive protein, but not myocardial infarction. We also found evidence that variation in desaturase genes modified the association between dietary intake of alpha-linolenic acid and serum low-density lipoprotein cholesterol. Futhermore, we established a novel association between variation in the gene coding for fatty acid elongase-5 and serum low density lipoprotein- and total cholesterol. Finally, we demonstrated null associations of elongase polymorphisms with adipose tissue fatty acids, markers of systemic inflammation, serum high-density lipoprotein cholesterol and triglycerides, and nonfatal myocardial infarction. Future studies are warranted to replicate the observed associations as well as to elucidate the biological mechanisms underlying the effect of genetic variation in elongases and desaturases on cardiovascular health, especially in populations undergoing nutritional and epidemiologic transitions. Advisors/Committee Members: Baylin, Ana (Director), Linkletter, Crystal (Reader), Loucks, Eric (Reader), Ordovas, Jose (Reader).

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

Aslibekyan, S. (2011). Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11241/

Chicago Manual of Style (16^th Edition):

Aslibekyan, Stella. “Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study.” 2011. Doctoral Dissertation, Brown University. Accessed November 12, 2019. https://repository.library.brown.edu/studio/item/bdr:11241/.

MLA Handbook (7^th Edition):

Aslibekyan, Stella. “Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study.” 2011. Web. 12 Nov 2019.

Vancouver:

Aslibekyan S. Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study. [Internet] [Doctoral dissertation]. Brown University; 2011. [cited 2019 Nov 12]. Available from: https://repository.library.brown.edu/studio/item/bdr:11241/.

Council of Science Editors:

Aslibekyan S. Genetic and Lifestyle Predictors of Nonfatal Myocardial Infarction in the Costa Rica Study. [Doctoral Dissertation]. Brown University; 2011. Available from: https://repository.library.brown.edu/studio/item/bdr:11241/

5. DiBello, Julia R. Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans.

Degree: PhD, Division of Biology and Medicine. Epidemiology, 2009, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:82/

► Traditional analyses in nutritional epidemiology relate single nutrients or foods to disease risk. Dietary pattern analysis is increasingly preferred to analysis of single nutrients as… (more)

▼ Traditional analyses in nutritional epidemiology relate single nutrients or foods to disease risk. Dietary pattern analysis is increasingly preferred to analysis of single nutrients as patterns account for combinations of nutrients that may be interactive or synergistic and create uncorrelated patterns from many highly correlated nutrients that may have small or undetectable effects on disease risk when considered alone. Principal component analysis (PCA), one of the major methods for deriving dietary patterns, combines correlated variables into weighted summations that "account for" much of the information contained in the original variables. One limitation of this approach when attempting to relate dietary patterns to the occurrence of disease is that patterns explaining large percentages of variation in food intake do not necessarily explain an equivalent amount of variation in nutrient intake. The effects of diet on the risk of disease are likely mediated through specific macro and micronutrients and thus patterns derived using PCA may not be associated with disease risk. Reduced rank regression (RRR) and partial least squares regression (PLS) are proposed alternatives to PCA and include knowledge about intermediary variables (response variables) on the pathway to disease in the derivation of dietary patterns. These three methods (PCA, PLS, RRR) were first applied in a Costa Rican population. All three methods identified a similar dietary pattern associated with significant decreased risk of first incident myocardial infarction (MI). However, PLS and PCA identified additional patterns significantly associated with MI risk and characterized by nutrients not previously considered to play a major role in the pathogenesis of MI in this population. PLS was subsequently applied among Samoan Islanders resulting in neo-traditional and more modern dietary patterns that were related to metabolic syndrome occurrence. Finally, PCA was applied using National Health and Nutritional Examination Data (NHANES) among US adolescents 12-19 years of age and patterns related to decreased fasting plasma glucose and increased body mass index were derived. The flexibility allowed by PLS and PCA, to derive patterns partially (PLS) or completely (PCA) unconstrained by the choice of response variables is important to consider when deciding which method to use. Advisors/Committee Members: Baylin, Ana (director), McGarvey, Stephen (reader), Goldberg, Robert (reader), Kraft, Peter (reader).

Subjects/Keywords: cardiovascular disease

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APA (6^th Edition):

DiBello, J. R. (2009). Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:82/

Chicago Manual of Style (16^th Edition):

DiBello, Julia R. “Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans.” 2009. Doctoral Dissertation, Brown University. Accessed November 12, 2019. https://repository.library.brown.edu/studio/item/bdr:82/.

MLA Handbook (7^th Edition):

DiBello, Julia R. “Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans.” 2009. Web. 12 Nov 2019.

Vancouver:

DiBello JR. Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans. [Internet] [Doctoral dissertation]. Brown University; 2009. [cited 2019 Nov 12]. Available from: https://repository.library.brown.edu/studio/item/bdr:82/.

Council of Science Editors:

DiBello JR. Dietary Patterns and Cardiovascular Disease in Three Populations: US Adolescents, Samoan Islanders and Costa Ricans. [Doctoral Dissertation]. Brown University; 2009. Available from: https://repository.library.brown.edu/studio/item/bdr:82/

6. Sands, Megan Rae. Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease.

Degree: PhD, Epidemiology, 2012, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:297542/

► A large body of evidence from both observation studies and clinical trials suggests that sleep quality and quantity is implicated in the pathogenesis of cardiovascular… (more)

▼ A large body of evidence from both observation studies and clinical trials suggests that sleep quality and quantity is implicated in the pathogenesis of cardiovascular disease (CVD). Over the past century, westernized societies have seen a marked shift in sleep patterns, including a substantial decrease in sleep duration and increased reporting of poor sleep quality. CVD accounts for 1 in 2.9 deaths in the United States. Given the significant burden of this disease, it is important to identify novel opportunities for prevention. This dissertation addresses the association between sleep and CVD risk by examining underlying subclinical mechanisms, as well as incident coronary outcomes. The association between objectively assessed sleep duration and carotid intima-media thickness (IMT), a subclinical biomarker of CVD, is examined among middle-aged adults in the Coronary Artery Risk Development in Young Adults study. Findings suggest that shorter sleep duration was associated with greater IMT among men but not women after controlling for demographics and CVD risk markers. The association between sleep duration and sleep quality with coronary outcomes is then assessed in postmenopausal women participating in the Women’s Health Initiative cohort study. Hazard ratios were computed using Cox proportional hazards models, and findings suggested that among postmenopausal women, those individuals with prolonged sleep and with a high level of insomnia had over double the risk of coronary heart disease (CHD). Habitual snoring, a correlate and early symptom of sleep apnea, was also associated with a modest increased risk of incident CHD and CVD, independent of demographics and risk markers. This work has demonstrated that one must take gender and age into account when assessing the impact of sleep on coronary disease. Furthermore, despite the large number of epidemiologic studies supporting a U-shaped association between sleep duration and CVD, it is increasingly important to consider characteristics of sleep quality, such as sleep disturbance, insomnia and apnea risk, when assessing the sleep duration and CVD association. Additional studies are needed to elucidate why findings differ by age group and gender, and to identify additional biological mechanisms underlying the observed associations. Advisors/Committee Members: Loucks, Eric (Director), Eaton, Charles (Reader), Lu, Bing (Reader), , (Director).

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

Sands, M. R. (2012). Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:297542/

Chicago Manual of Style (16^th Edition):

Sands, Megan Rae. “Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease.” 2012. Doctoral Dissertation, Brown University. Accessed November 12, 2019. https://repository.library.brown.edu/studio/item/bdr:297542/.

MLA Handbook (7^th Edition):

Sands, Megan Rae. “Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease.” 2012. Web. 12 Nov 2019.

Vancouver:

Sands MR. Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease. [Internet] [Doctoral dissertation]. Brown University; 2012. [cited 2019 Nov 12]. Available from: https://repository.library.brown.edu/studio/item/bdr:297542/.

Council of Science Editors:

Sands MR. Sleep Quality and Quantity as Risk Factors for Cardiovascular Disease. [Doctoral Dissertation]. Brown University; 2012. Available from: https://repository.library.brown.edu/studio/item/bdr:297542/

7. joyce, nina. Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20.

Degree: PhD, Epidemiology, 2016, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:674094/

► In 2008 the American Academy of Pediatrics (AAP) updated a previous set of guidelines on treatment of hypercholesterolemia in children from 1998. Despite evidence linking… (more)

▼ In 2008 the American Academy of Pediatrics (AAP) updated a previous set of guidelines on treatment of hypercholesterolemia in children from 1998. Despite evidence linking early treatment to reduced risk of CVD later in life, the 2008 AAP guidelines proved controversial when they suggested more aggressive screening and treatment of LDL-C in children and lowering the minimum age of pharmacological treatment in form of lipid lowering therapy (LLT) from 10 to 8 years old, for cases in which lifestyle modifications fail to reduce serum cholesterol to acceptable levels. Critics feared that the guidelines would lead to excessive use of pharmacological treatment, and more specifically, potentially inappropriate pharmacological treatment for children with life-style related dyslipidemias, such as those related to obesity. Included in the controversy was the fact that there were no long-term studies of the safety of LLT in children. While statins are considered to have a beneficial safety profile in adults, it was not clear that this extended to children. And in fact, there were reasons to believe that the risks in children may differ from that in adults, given both their level of development and the longer duration of expected use. However, lost in the controversy is the absence of a comprehensive evaluation of the use and safety of LLT treatment in children. The objective of this proposal is to evaluate safety of statin treatment and patterns of LLT initiation and adherence in children ages 8 to 20. In specific we studied patterns of LLT use, as both a function of initiation of LLT and adherence post-initiation. Addition, we studied the risk of diabetes associated with statin use in children- a risk which has recently been identified in adults and which could have a significant effect on the risk-benefit assessment of statin treatment in childhood. This will represent the first assessment of pediatric LLT during a period when the earliest children subjected to the obesity epidemic are coming into young adulthood. Advisors/Committee Members: Wellenius, Gregory (Director), Zachariah, Justin (Reader), Trivedi, Amal (Reader), Eaton, Charles (Reader).

Subjects/Keywords: cardiovascular disease

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APA (6^th Edition):

joyce, n. (2016). Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:674094/

Chicago Manual of Style (16^th Edition):

joyce, nina. “Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20.” 2016. Doctoral Dissertation, Brown University. Accessed November 12, 2019. https://repository.library.brown.edu/studio/item/bdr:674094/.

MLA Handbook (7^th Edition):

joyce, nina. “Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20.” 2016. Web. 12 Nov 2019.

Vancouver:

joyce n. Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20. [Internet] [Doctoral dissertation]. Brown University; 2016. [cited 2019 Nov 12]. Available from: https://repository.library.brown.edu/studio/item/bdr:674094/.

Council of Science Editors:

joyce n. Patterns and Side Effects of Lipid Lowering Therapy in Children Ages 8 to 20. [Doctoral Dissertation]. Brown University; 2016. Available from: https://repository.library.brown.edu/studio/item/bdr:674094/

8. Agha, golareh. Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease.

Degree: PhD, Epidemiology, 2014, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:386164/

► Cardiovascular disease (CVD) is complex and chronic in nature, resulting over time from multiple factors. First, CVD rarely develops due to the presence of a… (more)

▼ Cardiovascular disease (CVD) is complex and chronic in nature, resulting over time from multiple factors. First, CVD rarely develops due to the presence of a single risk factor in isolation; rather, multiple risk factors contribute to disease independently, cumulatively, and interactively. Furthermore, risk for CVD begins early in life, with growing evidence that exposures acting as early as the fetal period may have an impact on CVD that manifests in adulthood. Understanding the etiology of CVD thus requires careful consideration of such complex processes and trajectories; this dissertation used data from two prospective studies in order to better address such complexities. In the Women’s Health Initiative Observational study, the effect of a combination of four lifestyle factors on risk of heart failure (HF) was examined. Meeting the ‘healthy’ criteria for a higher number of lifestyle factors was associated with progressively lower risk of HF among post-menopausal women. Risk of HF was substantially lower among those who met all four healthy lifestyle criteria as compared with those who met the healthy criterion for any one factor. In the Longitudinal Effect on Aging Perinatal (LEAP) study, the biological mechanisms by which exposures in the fetal period may impact adiposity, an important and prevalent CVD risk factor, were explored. A particular biological mechanism of interest is the programming and regulation of gene expression through the epigenetic mechanism of DNA methylation. Accordingly, the impact of prenatally-assessed socioeconomic position on adulthood DNA methylation patterns was investigated among men and women from the LEAP study. Prenatal socioeconomic position was associated with adulthood adipose tissue DNA methylation patterns in women and not men, while no associations was seen with blood tissue DNA Methylation. The association between DNA methylation and adiposity was also investigated; adipose tissue DNA methylation patterns were associated with adiposity, whereas no association was observed in blood. In conclusion, results from this dissertation research suggest that multiple risk factors contribute collectively to CVD development. In addition, exposures early in life may contribute to adulthood CVD risk, and epigenetic mechanisms may be involved. Advisors/Committee Members: Loucks, Eric (Director), Houseman, E. Andres (Reader), Kelsey, Karl (Reader), Eaton, Charles (Reader).

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

Agha, g. (2014). Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:386164/

Chicago Manual of Style (16^th Edition):

Agha, golareh. “Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease.” 2014. Doctoral Dissertation, Brown University. Accessed November 12, 2019. https://repository.library.brown.edu/studio/item/bdr:386164/.

MLA Handbook (7^th Edition):

Agha, golareh. “Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease.” 2014. Web. 12 Nov 2019.

Vancouver:

Agha g. Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease. [Internet] [Doctoral dissertation]. Brown University; 2014. [cited 2019 Nov 12]. Available from: https://repository.library.brown.edu/studio/item/bdr:386164/.

Council of Science Editors:

Agha g. Socioeconomic, Behavioral, and Epigenetic Underpinnings of Cardiovascular Disease. [Doctoral Dissertation]. Brown University; 2014. Available from: https://repository.library.brown.edu/studio/item/bdr:386164/

9. Gong, Jian. Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica.

Degree: PhD, Epidemiology, 2011, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:11170/

► Abstract of "Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica" by Jian Gong, Ph.D., Brown University, May 2011Cardiovascular disease, obesity, and… (more)

Subjects/Keywords: Cardiovascular disease

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APA (6^th Edition):

Gong, J. (2011). Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11170/

Chicago Manual of Style (16^th Edition):

Gong, Jian. “Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica.” 2011. Doctoral Dissertation, Brown University. Accessed November 12, 2019. https://repository.library.brown.edu/studio/item/bdr:11170/.

MLA Handbook (7^th Edition):

Gong, Jian. “Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica.” 2011. Web. 12 Nov 2019.

Vancouver:

Gong J. Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica. [Internet] [Doctoral dissertation]. Brown University; 2011. [cited 2019 Nov 12]. Available from: https://repository.library.brown.edu/studio/item/bdr:11170/.

Council of Science Editors:

Gong J. Epidemiologic Studies of Coronary Heart Disease and Metabolic Risk in Costa Rica. [Doctoral Dissertation]. Brown University; 2011. Available from: https://repository.library.brown.edu/studio/item/bdr:11170/

Queen Mary, University of London

10. Khanji, Mohmed Yunus. Clinical effectiveness of tailored E2 coaching in reducing cardiovascular risk assessed using cardiovascular imaging and functional assessment : a primary prevention trial in moderate to high risk individuals.

Degree: PhD, 2017, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/24707 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765891

► Cardiovascular disease remains one of the leading causes of mortality globally. Innovative techniques are required to tackle its anticipated rise due to rising obesity, diabetes… (more)

▼ Cardiovascular disease remains one of the leading causes of mortality globally. Innovative techniques are required to tackle its anticipated rise due to rising obesity, diabetes and an ageing population. Personalised electronic coaching (eb coaching) using the Internet and emails may help motivate healthier living and be of clinical benefit in complementing current programmes for cardiovascular risk reduction. I investigated whether personalised ebcoaching on top of SOC was more clinically effective than SOC alone, in reducing cardiovascular risk in asymptomatic individuals with high cardiovascular risk. I lead a randomised controlled trial of 402 participants using robust surrogate markers to identify change over 6 months. I assessed the feasibility of using cardiovascular magnetic resonance surrogate markers to guide their use in future studies of lifestyle interventions. I performed systematic reviews to identify 1) similarities and differences among leading primary prevention guidelines that address cardiovascular screening and risk assessment and 2) guideline recommendations on lifestyle advice and interventions to identify how ebcoaching could be used and what advice to incorporate in ebcoaching platforms. I found modest but statistically significant improvements in both ebcoaching and SOC groups to a similar level. Personalised ebcoaching did not show additional benefit in a highbrisk primary prevention cohort. It is feasible to use cardiovascular surrogate markers derived from cardiovascular magnetic resonance in lifestyle interventions studies. However, further studies correlating change in these markers with longbterm outcomes are required. Considerable discrepancies exist in the guidelines on risk on cardiovascular screening and risk assessment, with no consensus on optimum screening strategies or classification of high risk thus affecting treatment threshold. Guidelines did highlight the importance of lifestyle interventions in primary prevention and generally provided similar advice. Ebcoaching should not be incorporated into current prevention programmes for high risk populations unless the tools are improved and effectiveness is proven.

Subjects/Keywords: Cardiovascular Imaging; Cardiovascular Risk Assessment; Cardiovascular disease

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APA (6^th Edition):

Khanji, M. Y. (2017). Clinical effectiveness of tailored E2 coaching in reducing cardiovascular risk assessed using cardiovascular imaging and functional assessment : a primary prevention trial in moderate to high risk individuals. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/24707 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765891

Chicago Manual of Style (16^th Edition):

Khanji, Mohmed Yunus. “Clinical effectiveness of tailored E2 coaching in reducing cardiovascular risk assessed using cardiovascular imaging and functional assessment : a primary prevention trial in moderate to high risk individuals.” 2017. Doctoral Dissertation, Queen Mary, University of London. Accessed November 12, 2019. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24707 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765891.

MLA Handbook (7^th Edition):

Khanji, Mohmed Yunus. “Clinical effectiveness of tailored E2 coaching in reducing cardiovascular risk assessed using cardiovascular imaging and functional assessment : a primary prevention trial in moderate to high risk individuals.” 2017. Web. 12 Nov 2019.

Vancouver:

Khanji MY. Clinical effectiveness of tailored E2 coaching in reducing cardiovascular risk assessed using cardiovascular imaging and functional assessment : a primary prevention trial in moderate to high risk individuals. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2017. [cited 2019 Nov 12]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/24707 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765891.

Council of Science Editors:

Khanji MY. Clinical effectiveness of tailored E2 coaching in reducing cardiovascular risk assessed using cardiovascular imaging and functional assessment : a primary prevention trial in moderate to high risk individuals. [Doctoral Dissertation]. Queen Mary, University of London; 2017. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/24707 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765891

Texas A&M University

11. Lester, Sandy Marie. Lipoprotein subclass analysis by immunospecific density.

Degree: 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-3123

► Apolipoprotein C-1 (apo C-1) enriched HDL has been described as an atherogenic form of HDL associated with an increased risk for cardiovascular disease (CVD). The… (more)

Subjects/Keywords: Lipoprotein; Cardiovascular Disease

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APA (6^th Edition):

Lester, S. M. (2009). Lipoprotein subclass analysis by immunospecific density. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-3123

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lester, Sandy Marie. “Lipoprotein subclass analysis by immunospecific density.” 2009. Thesis, Texas A&M University. Accessed November 12, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-3123.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lester, Sandy Marie. “Lipoprotein subclass analysis by immunospecific density.” 2009. Web. 12 Nov 2019.

Vancouver:

Lester SM. Lipoprotein subclass analysis by immunospecific density. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-3123.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lester SM. Lipoprotein subclass analysis by immunospecific density. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-3123

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State Polytechnic University – Pomona

12. Chen, Yee-Chi (Christina). The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk.

Degree: MS, Agriculture, 2014, California State Polytechnic University – Pomona

URL: http://hdl.handle.net/10211.3/123899

► Many functional foods have been studied for their ability to lower cardiovascular disease (CVD) risk. Avocados contain significant amounts of cardioprotective components such as monounsaturated… (more)

Subjects/Keywords: cardiovascular disease (CVD)

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APA (6^th Edition):

Chen, Y. (. (2014). The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk. (Masters Thesis). California State Polytechnic University – Pomona. Retrieved from http://hdl.handle.net/10211.3/123899

Chicago Manual of Style (16^th Edition):

Chen, Yee-Chi (Christina). “The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk.” 2014. Masters Thesis, California State Polytechnic University – Pomona. Accessed November 12, 2019. http://hdl.handle.net/10211.3/123899.

MLA Handbook (7^th Edition):

Chen, Yee-Chi (Christina). “The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk.” 2014. Web. 12 Nov 2019.

Vancouver:

Chen Y(. The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk. [Internet] [Masters thesis]. California State Polytechnic University – Pomona; 2014. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10211.3/123899.

Council of Science Editors:

Chen Y(. The Effect of Avocado Consumption on Food Displacement in Terms of Cardiovascular Disease Risk. [Masters Thesis]. California State Polytechnic University – Pomona; 2014. Available from: http://hdl.handle.net/10211.3/123899

13. BHANGU, JASPREET SINGH. Cardiovascular associations of falls and syncope in the elderly.

Degree: School of Medicine. CentreFor Medical Gerontology, 2017, Trinity College Dublin

URL: http://hdl.handle.net/2262/80573

► The principle aims of this doctoral investigation are to provide new insights into the relationship between cardiovascular disease (CVD) and falls in the elderly population… (more)

▼ The principle aims of this doctoral investigation are to provide new insights into the relationship between cardiovascular disease (CVD) and falls in the elderly population in Ireland. The rapidly ageing global demographic has meant that there will be a significant increase in healthcare burden from chronic disease. Falls are currently the most common cause of injury and resulting morbidity in people over the age of 65 years. Risk factors for falls have been established, however there has been very little in the way of measures which have proven preventative. Initially I had performed a literature review aiming to discern cardiovascular disorders which were associated with falls in the elderly. This had allowed me to systematically evaluate what associations have already been reported in the literature and where inconsistency still exists. This demonstrated multiple reported associations of cardiovascular disorders with falls, unexplained falls and syncope in elderly people. I have focused on disorders which result in syncope but can present as a fall in elderly patients. For my second paper I have used the Irish longitudinal Study Ageing (TILDA) to calculate the prevalence of falls, unexplained falls and syncope in the community dwelling Irish population. Also using the TILDA database I have been able to formulate logistic regression models which can be used to calculate odds ratios for self-reported health conditions and the exposures above. This allowed me to explore some of the associations in more depth using an observational study design. My third paper looked a cohort of patients who had presented to the emergency department during the time that we were conducting the observational study. Using electronic data linked to their medical records number I was able to estimate what the prevalence of unexplained falls, explained falls and syncope was in the emergency department. Additionally I used pre-specified resource variables to give some insight into the differences in resource usage between these groups when they present to the emergency department. For my fourth paper I have looked in more depth at the exact causes of the overlap of syncope and falls in the elderly. To do this we designed a study which examined all patients over the age of 50 who had presented to an emergency department in an urban hospital (St. James?s Hospital Dublin) with two or more unexplained falls in the last year. We entered 70 of these patients into a clinical trial to examine in more detail for the presence of cardiac arrhythmia which may be the underlying cause of the fall or syncopal episode. Lastly I have explored one of the risk factors which have been identified in the fifth paper- namely depression and medications which may contribute to syncope. This was again done at a population level using the TILDA database in order to make associations and draw conclusions. Advisors/Committee Members: Kenny, Rose.

Subjects/Keywords: Cardiovascular disease; Ageing

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APA (6^th Edition):

BHANGU, J. S. (2017). Cardiovascular associations of falls and syncope in the elderly. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/80573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BHANGU, JASPREET SINGH. “Cardiovascular associations of falls and syncope in the elderly.” 2017. Thesis, Trinity College Dublin. Accessed November 12, 2019. http://hdl.handle.net/2262/80573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BHANGU, JASPREET SINGH. “Cardiovascular associations of falls and syncope in the elderly.” 2017. Web. 12 Nov 2019.

Vancouver:

BHANGU JS. Cardiovascular associations of falls and syncope in the elderly. [Internet] [Thesis]. Trinity College Dublin; 2017. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/2262/80573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BHANGU JS. Cardiovascular associations of falls and syncope in the elderly. [Thesis]. Trinity College Dublin; 2017. Available from: http://hdl.handle.net/2262/80573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

14. Rinze, Ruth E. Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability.

Degree: PhD, 2011, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298

► The vascular endothelium plays a critical role in the regulation of vascular homeostasis. Endothelial cell injury, loss, survival and regeneration are important aspects in the… (more)

▼ The vascular endothelium plays a critical role in the regulation of vascular homeostasis. Endothelial cell injury, loss, survival and regeneration are important aspects in the response to vascular injury and pathogenesis of vascular disease. Re-endothelialization has been shown to be a key event in vascular repair after injury. Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key regulator of endothelial cell biology. Loss of NO bioavailability in endothelial dysfunction states is an early step in the development of atherosclerosis. The cofactor tetrahydrobiopterin (BH4) is essential for eNOS catalytic activity; when BH4 is limiting eNOS becomes enzymatically uncoupled, leading to the generation of superoxide instead of NO. eNOS function has been shown to be an important regulator of endothelial cell proliferation and survival as well as endothelial progenitor cell function. There is increasing evidence that the essential eNOS cofactor BH4 may enhance endothelial cell proliferation and endothelial progenitor function, both of which have the potential of enhancing vascular repair. The aim of this thesis is to evaluate the effect of BH4 bioavailability on endothelial cell growth in the absence and presence of vascular disease using primary endothelial cells from mice with genetic modifications in BH4 availability. Endothelial progenitor cell availability in lungs and bone marrow was investigated to address a second source for endothelial repair and potential therapeutic target. The duration of culture proved to be a major determinant of the biological phenotype of primary endothelial cells. Transgenic BH4 augmentation improved in vitro growth of primary endothelial cells in the presence but not in the absence of vascular disease. Endothelial progenitor cell content in lung tissue and bone marrow did not appear to be affected by transgenic BH4 augmentation. This thesis provides important new knowledge about the use of primary mouse endothelial cells in vascular research and insight into the role of BH4 availability on endothelial growth in a vascular disease setting.

Subjects/Keywords: 616.1; Cardiovascular disease

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APA (6^th Edition):

Rinze, R. E. (2011). Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298

Chicago Manual of Style (16^th Edition):

Rinze, Ruth E. “Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability.” 2011. Doctoral Dissertation, University of Oxford. Accessed November 12, 2019. http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298.

MLA Handbook (7^th Edition):

Rinze, Ruth E. “Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability.” 2011. Web. 12 Nov 2019.

Vancouver:

Rinze RE. Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability. [Internet] [Doctoral dissertation]. University of Oxford; 2011. [cited 2019 Nov 12]. Available from: http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298.

Council of Science Editors:

Rinze RE. Regulation of endothelial cell growth by tetrahydrobiopterin bioavailability. [Doctoral Dissertation]. University of Oxford; 2011. Available from: http://ora.ox.ac.uk/objects/uuid:511b53f4-b2a2-4f76-ae33-5f77dec69693 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555298

University of Oxford

15. Sebag-Montefiore, Liam M. Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function.

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851

► Heart failure (HF) is a common, disabling and deadly condition that causes high rates of morbidity and mortality worldwide. It is widely recognised that the… (more)

▼ Heart failure (HF) is a common, disabling and deadly condition that causes high rates of morbidity and mortality worldwide. It is widely recognised that the failing heart is energy-starved, and that restoring energy homeostasis is a promising approach towards improving cardiac output. This thesis aims to address the role of energetics in the failing heart, by focussing on modulation of the creatine transporter (CrT). Creatine (Cr), together with the phosphocreatine shuttle, plays a vital role in maintaining energy supplies via ATP in times of high energy demand. Key to the regulation of intracellular [Cr] is the CrT, a Na+ and Cl- - dependent membrane transporter. Previous CrT genetic mouse models include a knockout model, found to still express cardiac CrT, and a cardiac-specific CrT overexpressing (OE) model with large variations in myocardial [Cr] between animals and Cr levels high enough to cause spontaneous hypertrophy. To overcome the shortfalls of this CrT-OE model, a novel in vivo model of temporal inducible expression of CrT is described, using a cardiac-specific tetracycline inducible (Tet-On) system. Ten transgenic lines (RCT) were created with a construct containing the CrT-HA (CrT cDNA with an haemagglutinin epitope tag), following successful doxycyline-inducibility in vitro. Eight lines showed germline transmission, with LV CrT OE achieved in an individual mouse that displayed double LV [Cr] compared to WT. Issues with the inducer line (rtTA) were ruled out by its use in the creation of a luciferase overexpressing mouse line; all mice tested demonstrated LV luciferase expression in response to doxycycline feeding. The failure to overexpress CrT could be attributed to position or copy number dependent suppression, or to position effect variegation in the case of the single OE mouse obtained. Subsequent work focussed on regulatory pathways in vitro in a cell line of mouse fibroblasts stably overexpressing CrT-HA. Post-translational modifications (PTMs) had been previously suggested to regulate CrT activity. Two N-linked glycosylation sites exist, in addition to the putative phosphorylation sites. Inhibition of glycosylation by tunicamycin led to decreased CrT activity, reflected by decreased Cr uptake capacity. Strategies to confirm the presence of phosphorylation were employed, including isolation of CrT-HA by immunoprecipitation and subsequent LC-MS / MS analysis to identify PTMs. Although the presence of CrT was confirmed in 5 different sized species- one previously unreported- inadequate sequence coverage prevented identification of any PTM sites. Tyrosine phosphorylation was not detected using a phosphospecific antibody on immunopurified CrT-HA. Candidate signalling pathways in vitro were then investigated to elucidate CrT regulation, namely the IGF 1R signalling pathway. This study included a cardiomyocyte-like mouse cell line (HL-1) in addition to 3T3-CrT-HA. Exposure of cells to extracellular insulin, growth hormone and IGF-1 led to increased Cr uptake of 125% - 300% of normal.…

Subjects/Keywords: 616.129; Cardiovascular disease

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APA (6^th Edition):

Sebag-Montefiore, L. M. (2012). Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851

Chicago Manual of Style (16^th Edition):

Sebag-Montefiore, Liam M. “Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function.” 2012. Doctoral Dissertation, University of Oxford. Accessed November 12, 2019. http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851.

MLA Handbook (7^th Edition):

Sebag-Montefiore, Liam M. “Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function.” 2012. Web. 12 Nov 2019.

Vancouver:

Sebag-Montefiore LM. Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function. [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2019 Nov 12]. Available from: http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851.

Council of Science Editors:

Sebag-Montefiore LM. Modulation of myocardial creatine transporter levels and the effects of gene regulation and post-translational modification on its function. [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:ca17f5c1-ea79-4933-9d4c-c16f58a16abe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572851

Loyola University Chicago

16. Larimer, Karen Ann. Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois.

Degree: PhD, Nursing, 2011, Loyola University Chicago

URL: https://ecommons.luc.edu/luc_diss/199

► Background: Cardiovascular disease (CVD) is the number one cause of death in the United States and affects persons of all races and ethnicities. The… (more)

▼ Background: Cardiovascular disease (CVD) is the number one cause of death in the United States and affects persons of all races and ethnicities. The number of persons of Mexican ethnicity has increased significantly in the United States, notably in the community of Berwyn, a suburb of Chicago, IL where according to the U.S. 2010 census 60% of the community is now of Mexican descent. The factors that contribute to CVD risk in persons of Mexican decent within this community must be understood before culturally appropriate risk reduction strategies are designed and implemented. Purpose: The purpose of this community-based study is to gain a better understanding of selected social and physical health determinants and risk factors which may contribute to cardiovascular disease in people of Mexican descent in the community of Berwyn. Methods: The Healthy People 2010 model for assessing a community's health status guided this study. Multiple methods were used to characterize the prevalence of CVD risk factors among a community sample of Berwyn residents of Mexican descent. The impact of the selected social health determinants include language barriers, access to care, cultural behaviors, awareness of CVD and socioeconomic status and physical health determinants such as availability of parks and play lots, grocery stores and environmental pollution. Sources of data included: (1) community health screenings of 106 participants of Mexican descent who were assessed for blood pressure, total cholesterol, glucose, height, weight, body mass index, and age, (2) fifteen guided interviews of community key informants, (3) survey of participants in community/church-based CVD risk screenings, and (4) searches of publicly accessible internet databases related to the social and physical health determinants for this community. Data Analysis: Guided interviews were analyzed using standard qualitative procedures. STATA/MP version 1.1 was used for descriptive statistical analyses of the survey data and to determine proportions of individuals with abnormal risk values using accepted guidelines for cut-offs. The ARC geographic information system was used to plot locations of parks and stores within the community. Results: Risk prevalence data gleaned from interviews, in combination with quantitative results, revealed a triad of risk factors in this population. The most common risk factors among the 106 who participated in screenings were high body mass index (45% of the sample as overweight and additional 38% as obese), 52% with low HDL, 44% with elevated glucose, 35% with pre-hypertension; 33% with elevated total cholesterol. Reports from informants suggested that atherogenic diets and lack of physical activity among community members are common. However, key informant and individual community member interviews suggested that CVD does not rank as one of the top overall concerns for this Mexican population. Key informants also believed that lack of access to preventive health care is a common concern, with…

Subjects/Keywords: Cardiovascular Disease; Cardiovascular Risk; Hispanics; Mexicans; Nursing

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APA (6^th Edition):

Larimer, K. A. (2011). Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois. (Doctoral Dissertation). Loyola University Chicago. Retrieved from https://ecommons.luc.edu/luc_diss/199

Chicago Manual of Style (16^th Edition):

Larimer, Karen Ann. “Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois.” 2011. Doctoral Dissertation, Loyola University Chicago. Accessed November 12, 2019. https://ecommons.luc.edu/luc_diss/199.

MLA Handbook (7^th Edition):

Larimer, Karen Ann. “Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois.” 2011. Web. 12 Nov 2019.

Vancouver:

Larimer KA. Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois. [Internet] [Doctoral dissertation]. Loyola University Chicago; 2011. [cited 2019 Nov 12]. Available from: https://ecommons.luc.edu/luc_diss/199.

Council of Science Editors:

Larimer KA. Community Assessment of Cardiovascular Health and Risk Among People of Mexican Descent in Berwyn, Illinois. [Doctoral Dissertation]. Loyola University Chicago; 2011. Available from: https://ecommons.luc.edu/luc_diss/199

Euskal Herriko Unibertsitatea / Universidad del País Vasco

17. Lozano Bahamonde, Ainara. Programa de telemonitorización domiciliaria para el seguimiento de pacientes tras una hospitalización por insuficiencia cardiaca descompensada: análisis de efectividad.

Degree: 2018, Euskal Herriko Unibertsitatea / Universidad del País Vasco

URL: http://hdl.handle.net/10810/33010

► A pesar del creciente número de publicaciones en el ámbito de la telemedicina en pacientes con Insuficiencia Cardiaca su efectividad no está aún bien establecida.… (more)

Subjects/Keywords: cardiovascular pathology; disease; patología cardiovascular; enfermedad

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APA (6^th Edition):

Lozano Bahamonde, A. (2018). Programa de telemonitorización domiciliaria para el seguimiento de pacientes tras una hospitalización por insuficiencia cardiaca descompensada: análisis de efectividad. (Doctoral Dissertation). Euskal Herriko Unibertsitatea / Universidad del País Vasco. Retrieved from http://hdl.handle.net/10810/33010

Chicago Manual of Style (16^th Edition):

Lozano Bahamonde, Ainara. “Programa de telemonitorización domiciliaria para el seguimiento de pacientes tras una hospitalización por insuficiencia cardiaca descompensada: análisis de efectividad. ” 2018. Doctoral Dissertation, Euskal Herriko Unibertsitatea / Universidad del País Vasco. Accessed November 12, 2019. http://hdl.handle.net/10810/33010.

MLA Handbook (7^th Edition):

Lozano Bahamonde, Ainara. “Programa de telemonitorización domiciliaria para el seguimiento de pacientes tras una hospitalización por insuficiencia cardiaca descompensada: análisis de efectividad. ” 2018. Web. 12 Nov 2019.

Vancouver:

Lozano Bahamonde A. Programa de telemonitorización domiciliaria para el seguimiento de pacientes tras una hospitalización por insuficiencia cardiaca descompensada: análisis de efectividad. [Internet] [Doctoral dissertation]. Euskal Herriko Unibertsitatea / Universidad del País Vasco; 2018. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10810/33010.

Council of Science Editors:

Lozano Bahamonde A. Programa de telemonitorización domiciliaria para el seguimiento de pacientes tras una hospitalización por insuficiencia cardiaca descompensada: análisis de efectividad. [Doctoral Dissertation]. Euskal Herriko Unibertsitatea / Universidad del País Vasco; 2018. Available from: http://hdl.handle.net/10810/33010

University of Alberta

18. Hess, Scott L. Depression, Cardiovascular Disease and Amino Acids.

Degree: PhD, Department of Psychiatry, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/4b29b664s

► Major depression (MD) is one of the most prominent medical conditions worldwide in terms of societal cost and morbidity. MD has been associated with increased… (more)

▼ Major depression (MD) is one of the most prominent medical conditions worldwide in terms of societal cost and morbidity. MD has been associated with increased risk for cardiovascular disease (CVD) and conversely CVD has been associated with increased MD symptoms. Previous studies have shown that serum levels of nitric oxide (NO) were reduced in MD patients and in patients with CVD. We measured serum levels of arginine, the precursor amino acid of NO and found that they were reduced in MD subjects compared to healthy controls (HCs). Similarly, levels of citrulline, an amino acid formed during the formation of NO from arginine, were reduced. These results suggest that reduced levels of arginine may be contributing to the reduced NO observed in MD subjects. Dysfunction of the arteries has been identified as a precursor of CVD risk and has been proposed to be related to decreased NO. We hypothesized that endothelium function would be impaired in MD patients compared to HCs. Endothelial function was examined but no differences were observed between the two groups. It may be the case that despite risk of CVD being increased in MD patients, impaired endothelial dysfunction may not be observable. A variety of other amino acids proposed to be important in neurotransmission and the etiology of MD were measured in a population of unmedicated MD subjects and HCs matched for age, sex, dietary intake and lipid profiles; smokers and obese subjects were not included (similar conditions applied in the two studies mentioned above). Cysteine and histidine levels were elevated in the MD group. When male MD subjects were compared to their corresponding controls, the decreases in levels of arginine and citrulline were present, as was the increase in levels of cysteine, but levels of taurine, aspartate, glutamine and tryptophan were also significantly lower in MD subjects. In contrast, when female MD subjects were compared with their corresponding HCs, the differences were not significant. These results emphasize the importance of studying both male and female subjects and their corresponding controls when conducting such biomarker studies.

Subjects/Keywords: Cardiovascular Disease; Major Depression

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APA (6^th Edition):

Hess, S. L. (2014). Depression, Cardiovascular Disease and Amino Acids. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/4b29b664s

Chicago Manual of Style (16^th Edition):

Hess, Scott L. “Depression, Cardiovascular Disease and Amino Acids.” 2014. Doctoral Dissertation, University of Alberta. Accessed November 12, 2019. https://era.library.ualberta.ca/files/4b29b664s.

MLA Handbook (7^th Edition):

Hess, Scott L. “Depression, Cardiovascular Disease and Amino Acids.” 2014. Web. 12 Nov 2019.

Vancouver:

Hess SL. Depression, Cardiovascular Disease and Amino Acids. [Internet] [Doctoral dissertation]. University of Alberta; 2014. [cited 2019 Nov 12]. Available from: https://era.library.ualberta.ca/files/4b29b664s.

Council of Science Editors:

Hess SL. Depression, Cardiovascular Disease and Amino Acids. [Doctoral Dissertation]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/4b29b664s

Texas A&M University

19. Ghahramany, Ghazal. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women.

Degree: 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733

► About half of all deaths in developed countries are caused by cardiovascular disease. It is well known that cardiovascular disease (CVD) risk can be influenced… (more)

▼ About half of all deaths in developed countries are caused by cardiovascular disease. It is well known that cardiovascular disease (CVD) risk can be influenced by diet, but optimal dietary content of fatty acids continues to be debated. The effect of fatty acid composition of ground beef on selected cardiovascular disease risk indicators was evaluated with two primary goals. The first goal was to document effects of ground beef fatty acid composition on plasma lipoprotein concentrations, whereas the second goal was to determine the effects of ground beef fatty acid composition on gene expression in peripheral blood mononuclear cells (PBMC). In both studies the results were compared between men and women. Twelve men and women over age of 45 out of initially 15 completed a two-way crossover design. Subjects consumed five, 114-g ground beef patties per week for 5-wk periods separated by a 3-wk washout period. Patties contained on average 20% fat and monounsaturated fatty acid (MUFA): saturated fatty acid (SFA) of 0.8 and 1.1 for low- MUFA (conventional) ground beef high-MUFA (premium) ground beef patties, respectively. Blood was collected from each subject before and at the end of each diet period. Overall, the ground beef interventions decreased total plasma cholesterol, triacylglycerol, and very low density lipoprotein (VLDL) cholesterol. Plasma concentrations of high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol decreased and increased, respectively with premium ground beef consumption. The change in HDL cholesterol was significant in women but not in men suggesting that premium ground beef consumption had a greater impact on women than in men. For the second goal PBMC were isolated and the expression of selected genes was quantified by real-time PCR. ATP-binding cassette A1, ATP-binding cassette G1, and low-density lipoprotein receptor relative expression was increased with premium ground beef consumption. A significant increase was seen in stearoyl-Coenzyme-A desaturase 1 expression after premium ground beef treatment. With the exception of stearoyl-Coenzyme-A desaturase 1, all these genes were down-regulated with conventional ground beef consumption. Both sterol regulatory element binding transcription factor 1 and mediator complex subunit 1 were down-regulated after each beef patty treatment, but the effect was significant after consuming conventional ground beef. This suggests that genes involved in cholesterol metabolism were down-regulated with conventional ground beef consumption; whereas genes related to lipogenesis were up-regulated with premium ground beef consumption. From these data we concluded that different ground beef dietary interventions have different impacts on the PBMC gene expression that is related to cholesterol metabolism, inflammation and liver X receptor pathways. Advisors/Committee Members: Smith, Stephen B. (advisor), Riechman, Steven E. (committee member), Villalobos, Alice (committee member), Wu, Chaodong (committee member).

Subjects/Keywords: cardiovascular disease; Oleic acid; MUFA

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APA (6^th Edition):

Ghahramany, G. (2012). High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ghahramany, Ghazal. “High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women.” 2012. Thesis, Texas A&M University. Accessed November 12, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ghahramany, Ghazal. “High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women.” 2012. Web. 12 Nov 2019.

Vancouver:

Ghahramany G. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women. [Internet] [Thesis]. Texas A&M University; 2012. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ghahramany G. High-Oleic Ground Beef and Risk Factors for Cardiovascular Disease in Men and Postmenopausal Women. [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Bournele, Despina. Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο.

Degree: 2016, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/38345

► Cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels and one of the leading causes of death worldwide. The most… (more)

▼ Cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels and one of the leading causes of death worldwide. The most significant risk factors associated with the development of heart diseases include genetic and environmental factors such as hypertension, high blood cholesterol levels, diabetes, smoking, and obesity. Coronary artery disease and stroke account for the highest percentage of CVD deaths and stroke, cardiomyopathies, congenital heart diseases, heart valve defects and arrhythmias follow. The causes, prevention, and treatment of all forms of cardiovascular disease remain active fields of biomedical research, with hundreds of scientific studies published on a weekly basis.Cardiac valves develop as the heart contracts, and they function throughout the lifetime of the organism to prevent retrograde blood flow. Their precise morphogenesis is crucial for cardiac function and depends on the interaction between cardiac contractility and intracardiac flow dynamics. Multiple signaling pathways are implicated in the morphogenesis of cardiac valves but little is known about the molecular mechanisms that orchestrate their formation.Several unique characteristics make zebrafish an attractive model for elucidating the mechanisms underlying cardiac valve morphogeneis. Non-invasive imaging allows in vivo analyses of cardiovascular phenotypes. In addition, zebrafish hearts maintain their ability to regenerate throughout their lifetime, providing novel insights to understand human cardiac regeneration. Zebrafish has also emerged as a high-throughput but low-cost model organism that combines the advantages of forward and reverse genetics with phenotype-driven drug screenings. Functional verification of candidate genes from Genome Wide Association Studies (GWAS) has verified the role of several genes in the pathophysiology of CVDs. Zebrafish is a valuable tool for the identification of candidate genes for congenital heart defects, either through mutant characterization from genetic screens or functional annotation through morphant analysis.Here we describe the identification and the characterization of genes involved in cardiac valve formation. The mutant lines that were used have derived from a forward mutagenesis genetic screen that was carried out in order to identify mutant phenotypes relevant to various aspects of cardiac development. Bua mutant embryos show an outflow tract stenosis phenotype, which results to abnormal atrioventricular valve formation and retrograde blood flow. BH mutants have smaller heart, body axis and head compared to wild-type embryos and have also curved tail.In parallel, we carried out the characterization of a new transgenic line for the wnt/b-catenin signaling pathway. Apc mutant embryos which show constitutive active wnt/b-catenin signaling have also been used for the elaborate characterization of the Tg(7xTCF-Xla.Siam:nlsmCherry) transgenic line.The goal of this research project was the study of gene function, the identification of new signaling pathways and the…

Subjects/Keywords: Συγγενείς καρδιοπάθειες; Cardiovascular disease; Zebrafish

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APA (6^th Edition):

Bournele, D. (2016). Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/38345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bournele, Despina. “Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο.” 2016. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed November 12, 2019. http://hdl.handle.net/10442/hedi/38345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bournele, Despina. “Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο.” 2016. Web. 12 Nov 2019.

Vancouver:

Bournele D. Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10442/hedi/38345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bournele D. Μελέτη των μηχανισμών εκδήλωσης συγγενών καρδιοπαθειών με την χρήση του zebrafish ως πειραματικό μοντέλο. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. Available from: http://hdl.handle.net/10442/hedi/38345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dublin City University

21. Hughes, Sarah. Physiological and vascular responses to acute and chronic exercise in men and women with cardiovascular disease.

Degree: School of Health and Human Performance, 2013, Dublin City University

URL: http://doras.dcu.ie/17691/

► Study 1: Brachial artery flow-mediated dilation (FMD) using ultrasonography is used as a surrogate measure of coronary artery function. The purpose of this study was… (more)

Subjects/Keywords: Physiology; exercise; cardiovascular disease

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APA (6^th Edition):

Hughes, S. (2013). Physiological and vascular responses to acute and chronic exercise in men and women with cardiovascular disease. (Thesis). Dublin City University. Retrieved from http://doras.dcu.ie/17691/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hughes, Sarah. “Physiological and vascular responses to acute and chronic exercise in men and women with cardiovascular disease.” 2013. Thesis, Dublin City University. Accessed November 12, 2019. http://doras.dcu.ie/17691/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hughes, Sarah. “Physiological and vascular responses to acute and chronic exercise in men and women with cardiovascular disease.” 2013. Web. 12 Nov 2019.

Vancouver:

Hughes S. Physiological and vascular responses to acute and chronic exercise in men and women with cardiovascular disease. [Internet] [Thesis]. Dublin City University; 2013. [cited 2019 Nov 12]. Available from: http://doras.dcu.ie/17691/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hughes S. Physiological and vascular responses to acute and chronic exercise in men and women with cardiovascular disease. [Thesis]. Dublin City University; 2013. Available from: http://doras.dcu.ie/17691/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

22. Colaco, Brendon. Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample.

Degree: MS, Health Policy and Administration, 2011, Penn State University

URL: https://etda.libraries.psu.edu/catalog/12312

► Cardiovascular diseases are a complex set of diseases that affect the cardiovascular system and have fatal consequences if not identified and treated. There have been… (more)

Subjects/Keywords: MESA; Subclinical Cardiovascular Disease; Predictors

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APA (6^th Edition):

Colaco, B. (2011). Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample. (Masters Thesis). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/12312

Chicago Manual of Style (16^th Edition):

Colaco, Brendon. “Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample.” 2011. Masters Thesis, Penn State University. Accessed November 12, 2019. https://etda.libraries.psu.edu/catalog/12312.

MLA Handbook (7^th Edition):

Colaco, Brendon. “Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample.” 2011. Web. 12 Nov 2019.

Vancouver:

Colaco B. Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample. [Internet] [Masters thesis]. Penn State University; 2011. [cited 2019 Nov 12]. Available from: https://etda.libraries.psu.edu/catalog/12312.

Council of Science Editors:

Colaco B. Examination of the Predictors of Subclinical Cardiovascular Disease in a Diverse Sample. [Masters Thesis]. Penn State University; 2011. Available from: https://etda.libraries.psu.edu/catalog/12312

University of Manchester

23. Haque, Sahena. Premature senescence, endothelial turnover and accelerated atherosclerosis in SLE : the relationship between circulating endothelial cells, telomere length and lupus factors.

Degree: PhD, 2011, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/premature-senescence-endothelial-turnover-and-accelerated-atherosclerosis-in-sle-the-relationship-between-circulating-endothelial-cells-telomere-length-and-lupus-factors(cfac2b52-a73c-4672-90c3-946a47445946).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538513

► Systemic lupus erythematosus (SLE) is associated with premature onset of coronary heart disease and endothelial dysfunction. To date the mechanisms underlying this remain unclear. We… (more)

▼ Systemic lupus erythematosus (SLE) is associated with premature onset of coronary heart disease and endothelial dysfunction. To date the mechanisms underlying this remain unclear. We hypothesise there is premature biological ageing in patients with SLE as evidenced by a reduction in the mean telomere length of PBMC. Premature biological ageing is also evident in the vasculature of patients with SLE and reflected by relatively shortened telomeres of cells involved in vascular repair and regeneration i.e. endothelial progenitor cells (EPC). Furthermore, senescent EPC result in cellular imbalance with a relatively reduced number and/or function of circulating healthy EPC. We studied 200 SLE patients longitudinally over an average of 5.8 (5.2, 6.3) years and demonstrated progression of carotid plaque burden in 17.5%. Baseline traditional CHD risk factors did not influence plaque progression. We measured CD34/CD133+ EPC using flow cytometry in 54 SLE patients and 49 controls in cross-sectional study and demonstrated no significant difference between the groups. We further investigated number and function of EPC by enumerating colony-forming unit (CFU) in culture in 39 SLE patients and 27 controls and demonstrated a significant reduction in CFU number in SLE [median (IQR) CFU 5.7 (2.3, 8.0) in SLE vs. 10.0 (5.7, 15.0) in controls; p= 0.0016] and this difference was particularly marked in those under the age of 40 years [4 (2, 8) vs. 10.5 (7, 19), p= 0.03]. We measured relative telomere length of PBMC in SLE compared to age-matched controls using real-time qPCR in a cross-sectional study and demonstrated a significant reduction in SLE patients [0.97 (0.47, 1.57) and 1.53 (0.82, 2.29), p = P = 0.0008]. Further, telomere length of DNA extracted from CFU after 7 days in culture was quantified in a preliminary study of 5 SLE patients and 5 controls and demonstrated a trend to telomere length reduction in SLE patients. In conclusion there was evidence of significant progression of carotid plaque is in this cohort of female SLE patients. Further there is evidence of abnormal endothelial repair and premature senescence in SLE. Results support the hypothesis that there is a premature senescent phenotype in SLE and as such may present a novel therapeutic target to attenuate the risk of CHD in SLE.

Subjects/Keywords: 616.1; SLE; Cardiovascular disease

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APA (6^th Edition):

Haque, S. (2011). Premature senescence, endothelial turnover and accelerated atherosclerosis in SLE : the relationship between circulating endothelial cells, telomere length and lupus factors. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/premature-senescence-endothelial-turnover-and-accelerated-atherosclerosis-in-sle-the-relationship-between-circulating-endothelial-cells-telomere-length-and-lupus-factors(cfac2b52-a73c-4672-90c3-946a47445946).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538513

Chicago Manual of Style (16^th Edition):

Haque, Sahena. “Premature senescence, endothelial turnover and accelerated atherosclerosis in SLE : the relationship between circulating endothelial cells, telomere length and lupus factors.” 2011. Doctoral Dissertation, University of Manchester. Accessed November 12, 2019. https://www.research.manchester.ac.uk/portal/en/theses/premature-senescence-endothelial-turnover-and-accelerated-atherosclerosis-in-sle-the-relationship-between-circulating-endothelial-cells-telomere-length-and-lupus-factors(cfac2b52-a73c-4672-90c3-946a47445946).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538513.

MLA Handbook (7^th Edition):

Haque, Sahena. “Premature senescence, endothelial turnover and accelerated atherosclerosis in SLE : the relationship between circulating endothelial cells, telomere length and lupus factors.” 2011. Web. 12 Nov 2019.

Vancouver:

Haque S. Premature senescence, endothelial turnover and accelerated atherosclerosis in SLE : the relationship between circulating endothelial cells, telomere length and lupus factors. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2019 Nov 12]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/premature-senescence-endothelial-turnover-and-accelerated-atherosclerosis-in-sle-the-relationship-between-circulating-endothelial-cells-telomere-length-and-lupus-factors(cfac2b52-a73c-4672-90c3-946a47445946).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538513.

Council of Science Editors:

Haque S. Premature senescence, endothelial turnover and accelerated atherosclerosis in SLE : the relationship between circulating endothelial cells, telomere length and lupus factors. [Doctoral Dissertation]. University of Manchester; 2011. Available from: https://www.research.manchester.ac.uk/portal/en/theses/premature-senescence-endothelial-turnover-and-accelerated-atherosclerosis-in-sle-the-relationship-between-circulating-endothelial-cells-telomere-length-and-lupus-factors(cfac2b52-a73c-4672-90c3-946a47445946).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538513

University of Manchester

24. Mirjafari, Hoda. The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort.

Degree: PhD, 2011, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022

► Introduction: Patients with inflammatory polyarthritis (IP) have an excess risk of cardiovascular (CVD) mortality due to accelerated atherosclerosis. Markers identifying individuals with subclinical atherosclerosis as… (more)

▼ Introduction: Patients with inflammatory polyarthritis (IP) have an excess risk of cardiovascular (CVD) mortality due to accelerated atherosclerosis. Markers identifying individuals with subclinical atherosclerosis as measured by carotid intima-medial thickness (cIMT) and plaque may allow for attenuation of CVD risk. The objective of this study was to identify associated risk markers for atheromatous plaque and cIMT in an incident cohort of patients with early IP and to assess the risk markers associated with progression of cIMT and plaque after 2 years of follow-up.Methods: From 2004 to 2008 consecutive patients with early IP (≥2 joints swollen for ≥4 weeks) aged 18-65 years, who were within 24 months of symptom onset (±6 months) were recruited as part of a primary-care-based inception cohort. Apparently healthy controls were recruited on a frequency matched 'buddy' pair system. Patients underwent joint and blood pressure examination. Patients and controls underwent BMI measurement and their medication was recorded. Patients' blood was taken for measurement of rheumatoid factor, anti-citrullinated protein antibody, C reactive protein, glucose, lipids (LDL, HDL, triglycerides, paroxonase 1, apolipoprotein A1 and B) and markers of vascular damage (E-selectin, VCAM) and adipocytokines (leptin and adiponectin). Patients and controls underwent B mode Doppler ultrasound examination of the carotid arteries to assess for cIMT and the presence of plaque. In univariate analyses we identified factors that were associated with cIMT and plaque presence after age and gender adjustment. An additive stepwise multivariable logistic regression model was created to investigate the independence of any associations.Results: The 329 IP subjects had a median (IQR) age of 51 (42-58) years and 96 (29%) were male. IP subjects were more likely to be smokers, have a family history of CVD, have diabetes, higher BP and be overweight than their apparently healthy counterparts. IP subjects with plaque at baseline often did not have prior CVD. Subjects with IP had a 2.87 fold higher plaque frequency at the baseline but a similar median cIMT relative to the controls. Traditional CVD risk markers such as age, systolic BP and LDL were associated with cIMT and plaque at baseline. Adiponectin levels were negatively associated with cIMT and positively associated with plaque. IP subjects had a significant increase in their cIMT in the first 2 years of follow-up. The rate of progression of cIMT was 1.5-2.2 fold greater in IP than reported in the general population. Novel risk factors added to the model above and beyond traditional risk factors in predicting atherosclerosis. Steroid exposure at 2 years was associated with atherosclerosis progression.Conclusion: Markers known to be associated with atherosclerosis in the general population are associated with cIMT and plaque presence in early IP prior to established inflammatory disease and therapy. While cIMT in subjects and controls was the same at baseline there was an accelerated rate of progression of…

Subjects/Keywords: 616.1; Cardiovascular disease; Rheumatoid arthritis

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APA (6^th Edition):

Mirjafari, H. (2011). The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022

Chicago Manual of Style (16^th Edition):

Mirjafari, Hoda. “The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort.” 2011. Doctoral Dissertation, University of Manchester. Accessed November 12, 2019. https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022.

MLA Handbook (7^th Edition):

Mirjafari, Hoda. “The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort.” 2011. Web. 12 Nov 2019.

Vancouver:

Mirjafari H. The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2019 Nov 12]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022.

Council of Science Editors:

Mirjafari H. The prevalence and determinants of subclinical atherosclerosis in an early inflammatory polyarthritis inception cohort. [Doctoral Dissertation]. University of Manchester; 2011. Available from: https://www.research.manchester.ac.uk/portal/en/theses/the-prevalence-and-determinants-of-subclinical-atherosclerosis-in-an-early-inflammatory-polyarthritis-inception-cohort(071e4a81-5c0e-459a-8210-0c84b53f06a5).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549022

University of Oxford

25. Ferreira, Vanessa Melanie. T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application.

Degree: PhD, 2013, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810

► Cardiovascular magnetic resonance (CMR) is superior to other cardiac imaging modalities in its ability to perform multiparametric myocardial tissue characterisation. Commonly applied techniques include T2-weighted… (more)

▼ Cardiovascular magnetic resonance (CMR) is superior to other cardiac imaging modalities in its ability to perform multiparametric myocardial tissue characterisation. Commonly applied techniques include T2-weighted (T2W) imaging for detecting oedema and late gadolinium contrast enhancement imaging for detecting fibrosis, allowing characterisation of most cardiac conditions encountered in the clinical setting. While these techniques have proven useful, conventional MR images acquired by these techniques are displayed on an arbitrary scale and only semi-quantitative with some inherent deficiencies. Quantitative techniques, such as T1-mapping, allow direct quantification of tissue properties and may circumvent many of the issues of conventional MR imaging, with potential to offer more insight into diseased myocardium. Although T1-mapping has been well-established for brain T1-mapping, cardiac T1-mapping has been slow to mature due to technical and practical challenges. The aim of this thesis was to develop a novel method for cardiac T1-mapping that is robust and clinically applicable so that cardiac T1-mapping can transition from a research tool into clinical practice. Further, cardiac T1-mapping using this new technique was validated in normal and disease states, including its ability to detect regional and global myocardial oedema and acute myocarditis. This work developed a novel MR sequence for cardiac T1-mapping, named Shortened Modified Look-Locker Inversion Recovery (ShMOLLI). The conventional method (MOLLI) required 17 heart-beats (a 17 second breath-hold for a patient with a heart rate of 60 bpm) for the acquisition of one slice of T1-map. This is difficult to achieve for patients, especially those who are acutely ill and if whole heart coverage (~8 slices) were desired. One of the goals in the design of ShMOLLI was to bring the breath-hold time down to below 10 seconds so that patients may tolerate the protocol. The design of ShMOLLI was successful in breaching the 10-second breath-hold time without compromising the accuracy of T1 measurements compared to the conventional method; further, unlike MOLLI, ShMOLLI did not exhibit increasing error with increasing T1 or heart rates, making it advantageous in measuring long T1 values and at fast heart rates. These features of ShMOLLI make it a very attractive method ready for clinical application. The ShMOLLI method was then further applied to disease states, starting with models of acute myocardial oedema. ShMOLLI T1-mapping was performed in patients with acute stress-induced cardiomyopathy (model of global oedema) and in patients with regional oedema without infarction, and compared to T2W imaging. T1-mapping demonstrated an excellent diagnostic performance compared to the T2W methods in detecting acute myocardial oedema, whether it was global or regional. ShMOLLI T1-mapping was well-tolerated by acute cardiac patients and showed promise in its application to other conditions in which oedema would be a major component in the pathophysiology. ShMOLLI T1-mapping was…

Subjects/Keywords: 616.1237075; Cardiovascular disease; Medical Sciences

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APA (6^th Edition):

Ferreira, V. M. (2013). T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810

Chicago Manual of Style (16^th Edition):

Ferreira, Vanessa Melanie. “T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application.” 2013. Doctoral Dissertation, University of Oxford. Accessed November 12, 2019. http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810.

MLA Handbook (7^th Edition):

Ferreira, Vanessa Melanie. “T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application.” 2013. Web. 12 Nov 2019.

Vancouver:

Ferreira VM. T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application. [Internet] [Doctoral dissertation]. University of Oxford; 2013. [cited 2019 Nov 12]. Available from: http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810.

Council of Science Editors:

Ferreira VM. T1-mapping as a novel technique for myocardial tissue characterisation using cardiovascular magnetic resonance : from method development to clinical validation and application. [Doctoral Dissertation]. University of Oxford; 2013. Available from: http://ora.ox.ac.uk/objects/uuid:11b438a2-daa6-4143-bc45-4a1a540756cb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595810

University of Oxford

26. Turtle, Cameron William. Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis.

Degree: PhD, 2015, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022

► Mutations in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopathies. However, cardiac disease caused by mutations in non-sarcomeric proteins exhibit remarkably… (more)

▼ Mutations in genes encoding sarcomeric proteins are the most common cause of inherited cardiomyopathies. However, cardiac disease caused by mutations in non-sarcomeric proteins exhibit remarkably similar phenotypes, suggesting that common modes of pathogenesis might exist. It is of particular interest whether non-sarcomeric mutations result in impaired contractile function akin to sarcomeric diseases. Accordingly, this thesis describes the effect of cardiomyopathy-causing mutations to an energy sensing protein (AMPK γ2) and a small heat shock protein (αB-crystallin) on cardiac myofilament biomechanics and Ca²⁺ handling. Mutations in the regulatory γ2 subunit of AMP-activated kinase (AMPK), encoded by the PRKAG2 gene, cause a cardiomyopathy characterized by ventricular hypertrophy, electrophysiological abnormalities, and glycogen accumulation. Data from animal models in which the mutant transgene is overexpressed suggest that the electrophysiological aspects might be caused by excess glycogen, but that this is insufficient to account for all facets of the phenotype. A novel knock-in mouse expressing R299Q AMPK γ2 (homologous to the human R302Q mutation) was generated to model PRKAG2 cardiomyopathy more accurately. Assessment of the cardiac phenotype at two months to determine the early events in disease pathogenesis revealed systolic and diastolic dysfunction in mutant animals, with no excess glycogen detected. Analysis of acetyl-CoA carboxylase phosphorylation at S79 suggested increased basal AMPK activity in mutant animals. Increased sarcomeric Ca2+ sensitivity of contractile activation was observed in demembranated cardiac trabeculae from mutant animals, associated with decreased phosphorylation of cardiac troponin I at S23/S24 and increased phosphorylation at S150. Treatment with protein kinase A normalized this difference in Ca2+ sensitivity, suggesting that reduced PKA phosphorylation is the primary abnormality in mutant tissue. Cardiomyocytes from mutant animals exhibited slowed contractile and Ca2+ reuptake rates, associated with reduced phosphorylation of phospholamban and myosin binding protein C, as well as an increased response to isoproterenol. The lack of glycogen accumulation in these animals, combined with abnormal contractile and Ca²⁺ handling properties, reveals a more nuanced interpretation of the mechanism of PRKAG2 cardiomyopathy development. Further, the newly identified interaction between energy- (AMPK) and stress- (PKA) signalling networks may be of importance in numerous additional disease pathways. This thesis clarifies the role of αB-crystallin, and its cardiomyopathy-causing mutant (R157H), in regulating cardiac muscle stiffness. Specifically, mass spectrometry data revealed that αB-crystallin forms large oligomers and binds to titin Ig domains. Nuclear magnetic resonance confirmed this binding and suggested that αB-crystallin's C-terminal is responsible for titin binding. A…

Subjects/Keywords: 616.1; Cardiovascular disease; Cardiomyopathy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Turtle, C. W. (2015). Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022

Chicago Manual of Style (16^th Edition):

Turtle, Cameron William. “Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis.” 2015. Doctoral Dissertation, University of Oxford. Accessed November 12, 2019. http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022.

MLA Handbook (7^th Edition):

Turtle, Cameron William. “Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis.” 2015. Web. 12 Nov 2019.

Vancouver:

Turtle CW. Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis. [Internet] [Doctoral dissertation]. University of Oxford; 2015. [cited 2019 Nov 12]. Available from: http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022.

Council of Science Editors:

Turtle CW. Altered contractile mechanics and Ca²⁺ handling contribute to cardiomyopathy pathogenesis. [Doctoral Dissertation]. University of Oxford; 2015. Available from: http://ora.ox.ac.uk/objects/uuid:26d4cbaa-bb2f-4108-9659-123dc0cd96cd ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667022

University of Oxford

27. Dall'Armellina, Erica. Applications of 3 Tesla CMR in acute coronary syndromes (ACS).

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619

► Introduction: There is a pressing clinical need to treat patients with acute coronary syndrome (ACS) timely and efficiently in order to improve their prognosis. Standard… (more)

▼ Introduction: There is a pressing clinical need to treat patients with acute coronary syndrome (ACS) timely and efficiently in order to improve their prognosis. Standard tools available in ED, while useful, do not comprehensively characterize ACS for either diagnosis or risk stratification. The role of CMR in ACS is emerging because it allows assessment of both myocardial composition and function. Newer CMR techniques such as: a) T2 W imaging for assessing myocardial oedema and area at risk B) pre contrast T1 mapping techniques for quantitative characterization of the tissue composition, are adding further utility for CMR in ACS. At present the clinical use of these techniques is still limited and further investigations are needed to assess their clinical applicability in ACS patients. Aims: The aims of this thesis were several. Firstly we sought to establish a CMR protocol for imaging ACS patients on a 3T CMR scanner. In order to do so, we validated a novel T2 W technique for oedema imaging (T2 prep SSFP) at 3T. Second, we aimed to perform a detailed study of the time course of oedema in ACS patients in order to establish the appropriate imaging time for the assessment of area at risk. Third, by applying T2W acute oedema imaging, we sought to investigate the functional and pathological meaning of complicated remote plaques in patients with multivessel disease. Finally, we aimed to establish whether, in comparison to standard CMR techniques, novel precontrast T1 mapping allows better characterization of the acutely injured myocardium and whether it can predict long-term functional recovery. Methods: The research studies were all performed on a 3T Trio Siemens scanner. In the initial stage of the research, we validated the T2 W technique performing phantom work and scanning both volunteers and patients to assess the uniformity of signal intensity in the myocardium and to establish a threshold based method to post process the images. We then established a CMR protocol for ACS including oedema imaging, T1 mapping imaging, perfusion, functional and late gadolinium enhancement imaging. Patients with acute myocardial infarction (both ST elevation myocardial infarction (STEMI) and non STEMI) were scanned at 4 different time points after the acute event (3 scans within 2 weeks and one at 6 months). All STEMI patients underwent primary percutaneous coronary intervention (PCI) while the non-STEMI patients underwent coronary angiography and /or PCI. Results: We validated the T2prep SSFP technique at 3T, highlighting its limitations and establishing a threshold of mean ± 2SD to assess myocardial oedema. We found that the optimal imaging window to assess the maximal expression of myocardial oedema was within 1 week from the acute event in patients with ST elevation MI. Also, our results showed a reduction of LGE over time (from acute to chronic) in segments which also showed improvement in contractile function indicating that even segments with transmural LGE assessed in the early hours post event could be viable. By applying…

Subjects/Keywords: 616.123; Cardiovascular disease; Medical sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dall'Armellina, E. (2012). Applications of 3 Tesla CMR in acute coronary syndromes (ACS). (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619

Chicago Manual of Style (16^th Edition):

Dall'Armellina, Erica. “Applications of 3 Tesla CMR in acute coronary syndromes (ACS).” 2012. Doctoral Dissertation, University of Oxford. Accessed November 12, 2019. http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619.

MLA Handbook (7^th Edition):

Dall'Armellina, Erica. “Applications of 3 Tesla CMR in acute coronary syndromes (ACS).” 2012. Web. 12 Nov 2019.

Vancouver:

Dall'Armellina E. Applications of 3 Tesla CMR in acute coronary syndromes (ACS). [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2019 Nov 12]. Available from: http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619.

Council of Science Editors:

Dall'Armellina E. Applications of 3 Tesla CMR in acute coronary syndromes (ACS). [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:8b0d2e66-d6f5-4eaa-bfda-5887cefdeb19 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589619

University of Oxford

28. Patel, Jyoti. The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis.

Degree: PhD, 2011, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814

► Chemokine-induced macrophage recruitment into the vascular wall is an early pathological event in the progression of atherosclerosis. Macrophage activation and chemotaxis during cell recruitment are… (more)

▼ Chemokine-induced macrophage recruitment into the vascular wall is an early pathological event in the progression of atherosclerosis. Macrophage activation and chemotaxis during cell recruitment are mediated by chemokine ligation of multiple G-protein coupled receptors. The Regulator of G-Protein Signalling-1 (RGS-1) acts to down-regulate the response to sustained chemokine stimulation. Studies in this laboratory have shown Rgs1 is up-regulated in atherosclerotic ApoE^-/- mice in association with atherosclerotic plaque progression and published findings have reported that RGS1 is highly expressed in leukocytes. However an in vivo role for RGS-1 in macrophage function or in atherosclerosis has not been investigated. This thesis aimed to address the hypothesis that RGS1 has an important role in atherosclerosis and modulates the inflammatory response by controlling chemokine signalling and macrophage chemotaxis to atherosclerotic plaques. To investigate the role of RGS1 in macrophage function and the development of atherosclerosis, Rgs1^-/- mice were characterised on the ApoE^-/- background. Flow cytometric analysis of leukocytes in blood, spleen and bone marrow indicated Rgs1^-/-ApoE^-/- mice had no significant differences in the numbers of monocytes or lymphocytes compared to ApoE^-/- mice. Rgs1 was found to be highly expressed in macrophages from ApoE^-/- mice compared to B-lymphocytes, where it has a non-redundant role, and other cells involved in plaque formation. Furthermore, Rgs1 is up-regulated with monocyte-macrophage activation by innate stimuli. For the first time, RGS1 was shown to affect chemokine receptor signalling in macrophages in vitro. Rgs1^-/-ApoE^-/- macrophages showed significantly enhanced chemotaxis to CCL2, CCL3 and CCL5 and impaired homologous desensitisation to the chemokine CCL5 in comparison to ApoE^-/- cells. To determine the role of RGS-1 in leukocyte trafficking and atherosclerosis, a detailed atherosclerosis study was carried out. Rgs1^-/-ApoE^-/- mice had significantly less lesion formation in the aortic roots at 9-weeks and in the aorta at 16-weeks on a chow diet in comparison to ApoE^-/- mice. This was accompanied with decreased macrophage content in the aortic root at 9-weeks. To further investigate aortic leukocyte recruitment, an Angiotensin II-induced model of acute vascular inflammation was used. At 9 weeks of age, Rgs1^-/-ApoE^-/- mice had significantly less aortic CD45⁺ leukocytes and CD11b⁺ myeloid cells recruited to the aorta in comparison to ApoE^-/- mice. Collectively, these findings identify a new role for RGS-1 in macrophage function and support a role for RGS-1 in leukocyte recruitment and retention in the initial stages of atherosclerotic plaque formation. These results identify RGS1 as a novel target for the treatment of acute vascular inflammation and early atherosclerosis.

Subjects/Keywords: 616.136; Immunology; Cardiovascular disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patel, J. (2011). The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814

Chicago Manual of Style (16^th Edition):

Patel, Jyoti. “The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis.” 2011. Doctoral Dissertation, University of Oxford. Accessed November 12, 2019. http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814.

MLA Handbook (7^th Edition):

Patel, Jyoti. “The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis.” 2011. Web. 12 Nov 2019.

Vancouver:

Patel J. The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis. [Internet] [Doctoral dissertation]. University of Oxford; 2011. [cited 2019 Nov 12]. Available from: http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814.

Council of Science Editors:

Patel J. The role of regulator of G-Protein Signalling-1 in macrophage function and the development of atherosclerosis. [Doctoral Dissertation]. University of Oxford; 2011. Available from: http://ora.ox.ac.uk/objects/uuid:08df7a17-41f4-4ae4-a92f-bf5818a09d1d ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559814

Queen Mary, University of London

29. Grange, Robert Matthew Henry. Targeting multidrug resistance proteins and C-type natriuretic peptide to optimise cyclic GMP signalling in cardiovascular disease.

Degree: PhD, 2016, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/23786 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765816

► Cyclic-3',5'-guanosine monophosphate (cGMP) is a fundamental intracellular signalling molecule that regulates vascular homeostasis through the tight control of vascular smooth muscle cell (VSMC) reactivity (i.e.… (more)

▼ Cyclic-3',5'-guanosine monophosphate (cGMP) is a fundamental intracellular signalling molecule that regulates vascular homeostasis through the tight control of vascular smooth muscle cell (VSMC) reactivity (i.e. vasoconstriction/relaxation) and proliferation. Aberrant VSMC growth and sustained vasoconstriction are hallmarks of cardiovascular disease, exemplified by pulmonary hypertension (PH). Multidrug resistance proteins (MRPs) are membrane bound transporters that facilitate cGMP cellular export thereby representing a potential mechanism that regulates intracellular cGMP-driven signalling. C-type natriuretic peptide (CNP) is an important vasoactive peptide released from the endothelium that maintains vascular homeostasis. CNP binds to natriuretic peptide receptor-B (NPR-B), generating cGMP, and NPR-C, which acts as a clearance receptor removing CNP from the circulation and a signalling pathway regulating vascular function via a cGMP-independent mechanism. Herein, I investigated two separate hypotheses: that MRPs play an important role in maintaining vascular homeostasis, and that endothelium-derived CNP and its cognate receptor, NPR-C, protects against the development of PH. The role of MRPs in regulating vascular homeostasis was investigated using organ bath pharmacology, human VSMC (hVSMC) proliferation and measuring mean arterial blood pressure (MABP) in conscious and anaesthetised mice. To investigate the role of endothelium-derived CNP and NPR-C in PH, male and female CNP and NPR-C knockout (KO) mice were used in two experimental models of PH: hypoxia plus Sugen5416 (SU5416) and bleomycin-induced. The severity of PH was measured using right ventricular systolic pressure (RVSP), MABP, right ventricular hypertrophy (RVH) and pulmonary vascular remodelling. MRP inhibition resulted in concentration-dependent vasorelaxation of mouse aorta per se and increased the potency of cGMP-dependent vessel relaxation in response to activation of both particulate and soluble guanylate cyclases (pGC and sGC). MRP inhibition alone also caused concentration-dependent attenuation of hVSMC proliferation, and enhanced cGMP-mediated attenuation of hVSMC growth via pGC and sGC activation. MRP inhibition per se did not decrease MABP in either anaesthetised or telemeterised mice. However, MRP inhibition did dose-dependently enhance reductions in MABP due to pGC activation in anaesthetised mice. Deletion of endothelial cell-derived CNP (ecCNP KO) in male and female mice did not result in any significant differences in RVSP, RVH or pulmonary vascular remodelling between WT and KO in the hypoxia plus SU5416 model of PH. However, global deletion of NPR-C in both male and female mice caused a significant increase in RVH but not RVSP or vascular remodelling when compared to WT. Both male and female NPR-C KO mice developed significantly increased RVSP compared to WT in the bleomycin-induced model of PH. However, only females exhibited a significant increase in RVH and lung weight in addition to RVSP. In conclusion, MRP inhibition demonstrates…

Subjects/Keywords: Medicine & Dentistry; Cardiovascular disease

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APA (6^th Edition):

Grange, R. M. H. (2016). Targeting multidrug resistance proteins and C-type natriuretic peptide to optimise cyclic GMP signalling in cardiovascular disease. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/23786 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765816

Chicago Manual of Style (16^th Edition):

Grange, Robert Matthew Henry. “Targeting multidrug resistance proteins and C-type natriuretic peptide to optimise cyclic GMP signalling in cardiovascular disease.” 2016. Doctoral Dissertation, Queen Mary, University of London. Accessed November 12, 2019. http://qmro.qmul.ac.uk/xmlui/handle/123456789/23786 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765816.

MLA Handbook (7^th Edition):

Grange, Robert Matthew Henry. “Targeting multidrug resistance proteins and C-type natriuretic peptide to optimise cyclic GMP signalling in cardiovascular disease.” 2016. Web. 12 Nov 2019.

Vancouver:

Grange RMH. Targeting multidrug resistance proteins and C-type natriuretic peptide to optimise cyclic GMP signalling in cardiovascular disease. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2016. [cited 2019 Nov 12]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/23786 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765816.

Council of Science Editors:

Grange RMH. Targeting multidrug resistance proteins and C-type natriuretic peptide to optimise cyclic GMP signalling in cardiovascular disease. [Doctoral Dissertation]. Queen Mary, University of London; 2016. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/23786 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765816

Wake Forest University

30. Glendenning, Cate. CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME.

Degree: 2016, Wake Forest University

URL: http://hdl.handle.net/10339/64188

ABSTRACT

Subjects/Keywords: Cardiovascular disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Glendenning, C. (2016). CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/64188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Glendenning, Cate. “CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME.” 2016. Thesis, Wake Forest University. Accessed November 12, 2019. http://hdl.handle.net/10339/64188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Glendenning, Cate. “CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME.” 2016. Web. 12 Nov 2019.

Vancouver:

Glendenning C. CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME. [Internet] [Thesis]. Wake Forest University; 2016. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10339/64188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Glendenning C. CHANGES IN GAIT DURING COMMUNITY-BASED WEIGHT LOSS AND EXERCISE IN OBESE OLDER ADULTS WITH CARDIOVASCULAR DISEASE OR METABOLIC SYNDROME. [Thesis]. Wake Forest University; 2016. Available from: http://hdl.handle.net/10339/64188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations