subject:( Cancer Imaging)

1. Hartung, Niklas. Modelling of metastatic growth and in vivo imaging : Modélisation du processus métastatique et imagerie in vivo.

Degree: Docteur es, Mathématiques, 2014, Aix Marseille Université

URL: http://www.theses.fr/2014AIXM4763

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Un problème majeur du cancer est l'apparition de métastases, difficiles à détecter par l'imagerie médicale et qui peuvent progresser rapidement. Par le biais de la… (more)

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Un problème majeur du cancer est l'apparition de métastases, difficiles à détecter par l'imagerie médicale et qui peuvent progresser rapidement. Par le biais de la modélisation mathématique, nous espérons développer de nouveaux outils capables d'anticiper l'état métastatique d'un patient.Les deux premières parties de cette thèse sont dédiées au développement d'un tel outil, l'objectif étant sonutilisation chez l'animal voire en clinique. Dû aux variabilités intra- et inter-individuelles, nous sommes amenés à utiliser des modèles statistiques coûteux en temps de calcul.Dans la partie 1, nous étendons une approche introduite par Iwata et al. et développée dans l'équipe. Nousproposons une résolution numérique plus efficace basée sur la reformulation du modèle sous formed'équation intégrale de Volterra de type convolution, qui s'avère également utile pour montrer despropriétés théoriques du modèle. En outre, nous étudions une extension stochastique de ce modèle déterministe.Dans la partie 2, nous montrons que notre approche est adaptée à la description de données souris. Utilisant le cadre statistique des modèles nonlinéaires à effets mixtes, nous construisons un modèle métastatique identifiable à partir des données et nous interprétons les résultats biologiquement.La partie 3 regroupe des résultats issus de collaborations avec des biologistes. Nous avons commencé àmodéliser la croissance tumorale à partir d'observations par imagerie SPECT en utilisant un modèle deGyllenberg et Webb. D'autre part, afin d'améliorer la précision des observations SPECT, nous testons des techniques dedétection de contours via des méthodes volumes finis basées sur des schémas DDFV.

Metastasis is one of the major problems of cancer because metastases areoften difficult to detect by clinical imaging and may develop rapidly. With the help of mathematical modelling, we hope to developnew tools capable of anticipating the metastatic state of a patient.The first two parts of this thesis are dedicated to developing such a tool, destined for a preclinical oreven clinical use. As tumour growth dynamics vary strongly between individuals and since observations are often sparse andnoisy, we need to consider computationally expensive statistical tools.In the first part, we extend an approach introduced by Iwata et al. and developed by Barbolosi et al. In particular, wepropose a more efficient numerical resolution based on a model reformulation into a Volterra integral equation of convolutiontype. This reformulation also permits to prove theoretical model properties (regularity and identifiability). Moreover, we study a stochastic generalisation of this deterministic model.In the second part, we will show that our approach is suitable for the description of experimental data on tumour-bearing mice.Using the statistical framework of nonlinear mixed-effects modelling, we build a metastatic model that is identifiable fromour data. We then interpret the results biologically.The last part of this thesis contains several results obtained in collaboration with…

Advisors/Committee Members: Hubert, Florence (thesis director), Chapuisat, Guillemette (thesis director).

Subjects/Keywords: Modélisation; Oncologie; Métastases; Équations de renouvellement; Modèles à effets mixtes; Imagerie SPECT; Cancer modelling; Metastasis; Renewal equations; Mixed-Effects modelling; SPECT imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hartung, N. (2014). Modelling of metastatic growth and in vivo imaging : Modélisation du processus métastatique et imagerie in vivo. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2014AIXM4763

Chicago Manual of Style (16^th Edition):

Hartung, Niklas. “Modelling of metastatic growth and in vivo imaging : Modélisation du processus métastatique et imagerie in vivo.” 2014. Doctoral Dissertation, Aix Marseille Université. Accessed December 10, 2019. http://www.theses.fr/2014AIXM4763.

MLA Handbook (7^th Edition):

Hartung, Niklas. “Modelling of metastatic growth and in vivo imaging : Modélisation du processus métastatique et imagerie in vivo.” 2014. Web. 10 Dec 2019.

Vancouver:

Hartung N. Modelling of metastatic growth and in vivo imaging : Modélisation du processus métastatique et imagerie in vivo. [Internet] [Doctoral dissertation]. Aix Marseille Université 2014. [cited 2019 Dec 10]. Available from: http://www.theses.fr/2014AIXM4763.

Council of Science Editors:

Hartung N. Modelling of metastatic growth and in vivo imaging : Modélisation du processus métastatique et imagerie in vivo. [Doctoral Dissertation]. Aix Marseille Université 2014. Available from: http://www.theses.fr/2014AIXM4763

2. Tang, Jingjie. Innovative imaging systems and novel drug candidates for cancer therapy : The re-appropriation of former industrial spaces through contemporary creation : la Friche la Belle de Mai.

Degree: Docteur es, Chimie organique, 2016, Aix Marseille Université

URL: http://www.theses.fr/2016AIXM4021

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Le cancer est l'une des principales causes de décès dans le monde et reste une maladie difficile à traiter du fait des difficultés de pronostic,… (more)

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Le cancer est l'une des principales causes de décès dans le monde et reste une maladie difficile à traiter du fait des difficultés de pronostic, du développement rapide de métastases et de la résistance aux médicaments. Il en résulte une forte demande en méthodologies d'imagerie innovantes pour le diagnostic précoce et précis ainsi qu’en nouveaux agents anticancéreux possédant de nouveaux mécanismes pour surmonter la résistance aux médicaments. Le but de mon projet de recherche de doctorat était donc de contribuer à cet objectif.La première partie de ma thèse de doctorat a porté sur la création de systèmes sensibles et précis d'imagerie pour la détection de tumeurs cancéreuses en utilisant une nanotechnologie novatrice permettant la délivrance des agents d'imagerie spécifiquement dans les lésions tumorales. Nous avons conçu de nouveaux dendrimères amphiphiles pour assurer le transport de différents agents d'imagerie pour les imageries PET/SPECT, par résonance magnétique et par fluorescence optique. Ces systèmes d'imagerie ont été préparés soit par encapsulation de petites sondes d'imagerie à l'intérieur de nanomicelles dendritiques ou par fonctionnalisation de la surface hydrophile ou de la queue hydrophobe du dendrimère. La deuxième partie a eu pour objectif de développer de nouveaux agents anticancéreux possédant nouveaux mécanismes d’action et une meilleure activité antitumorale. A cet effet, nous avons conçu une série de nucléosides arylvinyltriazoles par réaction oxydante de Heck, ce qui nous a permis d'obtenir les composés désirés pourtant difficiles à synthétiser avec un très large éventail de substrats et une stéréosélectivité unique.

Cancer is one of the leading causes of death in the world, and remains a difficult disease to treat because of poor prognosis, rapid tumor metastasis and drug resistance. Therefore, innovative imaging modalities for early and precise diagnosis as well as new anticancer drug candidates with novel mechanisms to overcome drug resistance are in high demand. The aim of my PhD research project was to contribute to this goal.The first part of my PhD thesis was focused on establishing sensitive and precise imaging systems for cancer detection using innovative nanotechnology to deliver imaging agents specifically into tumor lesions. We designed and constructed novel amphiphilic dendrimers to carry different imaging agents for PET/SPECT imaging, magnetic resonance imaging and optical fluorescence imaging. These innovative imaging systems were prepared by either encapsulation of small imaging probes within the dendrimer nanomicelles, or functionalization of the dendrimer hydrophilic surface or hydrophobic tail. The second part of my PhD program aimed to develop new anticancer drug candidates with novel mechanisms for better anticancer activity. Therefore, we designed and synthesized a series of challenging arylvinyltriazole nucleosides via the oxidative Heck reaction, which allowed us to obtain the desired compounds with excellent substrate scope and unique stereoselectivity.

Advisors/Committee Members: Peng, Ling (thesis director), Quelever, Gilles (thesis director).

Subjects/Keywords: Dendrimères amphiphiles; Nanotransporteurs; Imagerie moléculaire; Diagnostic du cancer; Nucléosides aryles vinyles triazoles; Réaction oxydante de Heck; Amphiphilic dendrimers; Nanocarrier; Molecular imaging; Cancer diagnosis; Arylvinyltriazole nucleosides; Oxidative Heck reaction; 547

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APA (6^th Edition):

Tang, J. (2016). Innovative imaging systems and novel drug candidates for cancer therapy : The re-appropriation of former industrial spaces through contemporary creation : la Friche la Belle de Mai. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2016AIXM4021

Chicago Manual of Style (16^th Edition):

Tang, Jingjie. “Innovative imaging systems and novel drug candidates for cancer therapy : The re-appropriation of former industrial spaces through contemporary creation : la Friche la Belle de Mai.” 2016. Doctoral Dissertation, Aix Marseille Université. Accessed December 10, 2019. http://www.theses.fr/2016AIXM4021.

MLA Handbook (7^th Edition):

Tang, Jingjie. “Innovative imaging systems and novel drug candidates for cancer therapy : The re-appropriation of former industrial spaces through contemporary creation : la Friche la Belle de Mai.” 2016. Web. 10 Dec 2019.

Vancouver:

Tang J. Innovative imaging systems and novel drug candidates for cancer therapy : The re-appropriation of former industrial spaces through contemporary creation : la Friche la Belle de Mai. [Internet] [Doctoral dissertation]. Aix Marseille Université 2016. [cited 2019 Dec 10]. Available from: http://www.theses.fr/2016AIXM4021.

Council of Science Editors:

Tang J. Innovative imaging systems and novel drug candidates for cancer therapy : The re-appropriation of former industrial spaces through contemporary creation : la Friche la Belle de Mai. [Doctoral Dissertation]. Aix Marseille Université 2016. Available from: http://www.theses.fr/2016AIXM4021

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

3. Παπαδοπούλου, Παναγιώτα. Η απεικόνιση των κακοήθων όγκων των ωοθηκών με μαγνητική τομογραφία με ιστοπαθολογική συσχέτιση.

Degree: 2010, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/28303

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Ovarian cancer represents the leading cause of death among gynaecologic malignancies. Early signs and symptoms are usually absent and the disease evolves rapidly. As a… (more)

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Ovarian cancer represents the leading cause of death among gynaecologic malignancies. Early signs and symptoms are usually absent and the disease evolves rapidly. As a consequence, most patients present with advanced stage disease. The aim of this study was to evaluate the accuracy of Magnetic Resonance Imaging (MRI) in detection and characterization of adnexal masses and to identify the imaging features that can predict malignancy. We evaluated 174 patients with 213 tumours and tumour like lesions of the adnexa that consequently underwent surgical exploration. Various morphologic features were examined. The shape of the lesion, size, content, wall thickness, number of septa, septal thickness and presence or absence of blood and fat were recorded. Secondary features as ascites; lymphadenopathy and peritoneal implants were also noted. The findings were compared to surgical and pathologic findings and statistical analysis was performed. MRI had a sensitivity of 97%, specificity 89%, positive predictive value of 82%, negative predictive value of 98,4% and overall accuracy of 91,8%. Findings suggestive of malignancy were older patient age, a large diameter, a mixed cystic and solid lesion, thick wall, thick septa, presence of multiple septa, necrosis, ascites, lymphadenopathy and peritoneal implants. We conclude that MRI is an excellent technique, very sensitive and accurate for the detection and characterization of malignant adnexal masses. Its contribution to surgical planning and patient management is invaluable.

Ο καρκίνος των ωοθηκών αποτελεί την πιο θανατηφόρο γυναικολογική κακοήθεια. Σκοπός της μελέτης αυτής ήταν η αξιολόγηση της ακρίβειας της Μαγνητικής Τομογραφίας (ΜΤ) στην ανίχνευση των όγκων των ωοθηκών, το χαρακτηρισμό τους και την εκτίμηση της πιθανότητας κακοήθειας με βάση τα επιμέρους απεικονιστικά ευρήματα. Μελετήσαμε με ΜΤ 174 ασθενείς με 213 ογκόμορφες βλάβες των ωοθηκών που υποβλήθηκαν σε χειρουργική επέμβαση. Οι βλάβες εξετάστηκαν με βάση τα επιμέρους μορφολογικά χαρακτηριστικά. Καταγράφηκε το σχήμα της βλάβης, το μέγεθος, η σύσταση, το πάχος του τοιχώματος, ο αριθμός και η υφή των διαφραγμάτων, η παρουσία νέκρωσης, αίματος ή λίπους. Δευτερεύοντα ευρήματα όπως ο ασκίτης, η λεμφαδενοπάθεια και οι εμφυτεύσεις αναζητήθηκαν επίσης. Συγκρίναμε τα απεικονιστικά ευρήματα με τα ευρήματα του χειρουργείου και της παθολογοανατομικής μελέτης και ακολούθησε στατιστική επεξεργασία των αποτελεσμάτων. Η ΜΤ είχε ευαισθησία 97%, ειδικότητα 89%, θετική προγνωστική αξία 82%, αρνητική προγνωστική αξία 98,4% και ακρίβεια 91,8%. Ευρήματα ενδεικτικά κακοήθειας ήταν η μεγάλη ηλικία της εξεταζόμενης, μεγάλη διάμετρος της βλάβης, η παρουσία βλάβης μεικτής συμπαγούς και κυστικής υφής, η παρουσία παχέων τοιχωμάτων, πολλαπλών και παχέων διαφραγμάτων, η παρουσία νέκρωσης, η παρουσία ασκίτη, η παρουσία εμφυτεύσεων και η παρουσία λεμφαδενοπάθειας. Συμπερασματικά καταλήξαμε ότι η ΜΤ είναι μια εξαιρετική μέθοδος, ευαίσθητη και ακριβής, για την ανίχνευση και τον σωστό χαρακτηρισμό των κακοήθων βλαβών των ωοθηκών. Η συμβολή της στον…

Subjects/Keywords: Ωοθήκες; Καρκίνος ωοθηκών; Μαγνητική τομογραφία; Παθολογοανατομία; Κυσταδένωμα; Επιθηλιακοί όγκοι; Όγκοι στρώματος γεννητικής ταινίας; Όγκοι από αρχέγονα κύτταρα; Ovaries; Ovarian cancer; Magnetic resonance imaging; Pathology; Cystadenoma; Epithelial tumors; Sex cord stromal tumors; Germ cell tumors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Παπαδοπούλου, . �. (2010). Η απεικόνιση των κακοήθων όγκων των ωοθηκών με μαγνητική τομογραφία με ιστοπαθολογική συσχέτιση. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/28303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Παπαδοπούλου, Παναγιώτα. “Η απεικόνιση των κακοήθων όγκων των ωοθηκών με μαγνητική τομογραφία με ιστοπαθολογική συσχέτιση.” 2010. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed December 10, 2019. http://hdl.handle.net/10442/hedi/28303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Παπαδοπούλου, Παναγιώτα. “Η απεικόνιση των κακοήθων όγκων των ωοθηκών με μαγνητική τομογραφία με ιστοπαθολογική συσχέτιση.” 2010. Web. 10 Dec 2019.

Vancouver:

Παπαδοπούλου �. Η απεικόνιση των κακοήθων όγκων των ωοθηκών με μαγνητική τομογραφία με ιστοπαθολογική συσχέτιση. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2010. [cited 2019 Dec 10]. Available from: http://hdl.handle.net/10442/hedi/28303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Παπαδοπούλου �. Η απεικόνιση των κακοήθων όγκων των ωοθηκών με μαγνητική τομογραφία με ιστοπαθολογική συσχέτιση. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2010. Available from: http://hdl.handle.net/10442/hedi/28303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Arizona State University

4. Izady Yazdanabadi, Mohammadhassan. Confocal Laser Endomicroscopy Image Analysis with Deep Convolutional Neural Networks.

Degree: Neuroscience, 2019, Arizona State University

URL: http://repository.asu.edu/items/53650

Subjects/Keywords: Medical imaging; Computer science; Surgery; cancer detection; confocal laser endomicroscopy; convolutional neural networks; deep learning; digital pathology; glioma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Izady Yazdanabadi, M. (2019). Confocal Laser Endomicroscopy Image Analysis with Deep Convolutional Neural Networks. (Doctoral Dissertation). Arizona State University. Retrieved from http://repository.asu.edu/items/53650

Chicago Manual of Style (16^th Edition):

Izady Yazdanabadi, Mohammadhassan. “Confocal Laser Endomicroscopy Image Analysis with Deep Convolutional Neural Networks.” 2019. Doctoral Dissertation, Arizona State University. Accessed December 10, 2019. http://repository.asu.edu/items/53650.

MLA Handbook (7^th Edition):

Izady Yazdanabadi, Mohammadhassan. “Confocal Laser Endomicroscopy Image Analysis with Deep Convolutional Neural Networks.” 2019. Web. 10 Dec 2019.

Vancouver:

Izady Yazdanabadi M. Confocal Laser Endomicroscopy Image Analysis with Deep Convolutional Neural Networks. [Internet] [Doctoral dissertation]. Arizona State University; 2019. [cited 2019 Dec 10]. Available from: http://repository.asu.edu/items/53650.

Council of Science Editors:

Izady Yazdanabadi M. Confocal Laser Endomicroscopy Image Analysis with Deep Convolutional Neural Networks. [Doctoral Dissertation]. Arizona State University; 2019. Available from: http://repository.asu.edu/items/53650

Arizona State University

5. Fuentes, Alberto. Applications of Magnetic Resonance Cytography: Assessing Underlying Cytoarchitecture.

Degree: Biomedical Engineering, 2018, Arizona State University

URL: http://repository.asu.edu/items/51712

► In medical imaging, a wide variety of methods are used to interrogate structural and physiological differences between soft tissues. One of the most ubiquitous methods… (more)

▼ In medical imaging, a wide variety of methods are used to interrogate structural and physiological differences between soft tissues. One of the most ubiquitous methods in clinical practice is Magnetic Resonance Imaging (MRI), which has the advantage of limited invasiveness, soft tissue discrimination, and adequate volumetric resolution. A myriad of advanced MRI methods exists to investigate the microstructural, physiologic and metabolic characteristics of tissue. For example, Dynamic Contrast Enhanced (DCE) and Dynamic Susceptibility Contrast (DSC) MRI non-invasively interrogates the dynamic passage of an exogenously administered MRI contrast agent through tissue to quantify local tracer kinetic properties like blood flow, vascular permeability and tissue compartmental volume fractions. Recently, an improved understanding of the biophysical basis of DSC-MRI signals in brain tumors revealed a new approach to derive multiple quantitative biomarkers that identify intrinsic sub-voxel cellular and vascular microstructure that can be used differentiate tumor sub-types. One of these characteristic biomarkers called Transverse Relaxivity at Tracer Equilibrium (TRATE), utilizes a combination of DCE and DSC techniques to compute a steady-state metric which is particularly sensitive to cell size, density, and packing properties. This work seeks to investigate the sensitivity and potential utility of TRATE in a range of disease states including Glioblastomas, Amyotrophic Lateral Sclerosis (ALS), and Duchenne’s Muscular Dystrophy (DMD). The MRC measures of TRATE showed the most promise in mouse models of ALS where TRATE values decreased with disease progression, a finding that correlated with reductions in myofiber size and area, as quantified by immunohistochemistry. In the animal models of cancer and DMD, TRATE results were more inconclusive, due to marked heterogeneity across animals and treatment state. Overall, TRATE seems to be a promising new biomarker but still needs further methodological refinement due to its sensitivity to contrast to noise and further characterization owing to its non-specificity with respect to multiple cellular features (e.g. size, density, heterogeneity) that complicate interpretation.

Subjects/Keywords: Medical imaging; Biomedical engineering; Amyotrophic Lateral Sclerosis; Cancer Imaging; Cytography; DSC; Perfusion Imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fuentes, A. (2018). Applications of Magnetic Resonance Cytography: Assessing Underlying Cytoarchitecture. (Masters Thesis). Arizona State University. Retrieved from http://repository.asu.edu/items/51712

Chicago Manual of Style (16^th Edition):

Fuentes, Alberto. “Applications of Magnetic Resonance Cytography: Assessing Underlying Cytoarchitecture.” 2018. Masters Thesis, Arizona State University. Accessed December 10, 2019. http://repository.asu.edu/items/51712.

MLA Handbook (7^th Edition):

Fuentes, Alberto. “Applications of Magnetic Resonance Cytography: Assessing Underlying Cytoarchitecture.” 2018. Web. 10 Dec 2019.

Vancouver:

Fuentes A. Applications of Magnetic Resonance Cytography: Assessing Underlying Cytoarchitecture. [Internet] [Masters thesis]. Arizona State University; 2018. [cited 2019 Dec 10]. Available from: http://repository.asu.edu/items/51712.

Council of Science Editors:

Fuentes A. Applications of Magnetic Resonance Cytography: Assessing Underlying Cytoarchitecture. [Masters Thesis]. Arizona State University; 2018. Available from: http://repository.asu.edu/items/51712

Baylor University

6. [No author]. Quantitative cellular and molecular imaging of the intact tumor microenvironment.

Degree: 2018, Baylor University

URL: http://hdl.handle.net/2104/10436

► The causes underlying the extent and character of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity,… (more)

▼ The causes underlying the extent and character of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of individual patients. Tumors are complex and organized tissues that include multiple cell types, which together compose the tumor microenvironment (TME). The myeloid cells play a major role in TME and can be composed of heterogeneous cells with functions that can be grossly summarized as: (1) Antigen capture for presentation (dendritic cells, DCs) or for degradation (macrophages); (2) Tissue repair (macrophages) and (3) effector function (mast cells, monocytes, granulocytes). However, the functional status of myeloid cells in human tumors and variation between tumors and patients is not completely understood. This is an important gap in knowledge that needs to be addressed because myeloid antigen presenting cells (mAPCs) control cancer antigen presentation to T cells thereby launching and regulating anti-cancer immunity. Our studies focused therefore on two key approaches necessary to improve our understanding of myeloid cells in TME: 1. Analysis of myeloid cells in situ in tumors. To this end, we developed and applied a microscopy-based approach for quantitative and qualitative mapping of non-dissociated tumors. Indeed, current methods are based on tissue dissociation into single cell suspension, which is associated with cell loss and activation, possibly impacting observed phenotypes. This was combined with laser capture microdissection to lift the cells and transcriptional profiling of APCs based on their tissue location and antigen content; and 2. Humanized mouse models recapitulating human TME. Indeed, while syngeneic and genetically modified mouse models enable in vivo studies of the TME, substantial differences exist between human and mouse immune systems, possibly impacting translation of pre-clinical studies to the clinic. Therefore, we studied human myeloid cells in novel humanized mouse models that support the tumor progression and metastatic spread of human melanoma. Our results show that location of myeloid cells within the tissue, as well as antigen cargo, have a significant impact on cell’s transcriptomic profile and potentially function. Thus, our approach developed in the course of studies discussed herein might bring a new resolution to unraveling the biology of APCs within the TME. This in turn could have an impact beyond melanoma. Furthermore, the new humanized mouse models that we have studied bring the in vivo proof that human myeloid cells and macrophages contribute to tumor development and metastatic colonization. Advisors/Committee Members: Palucka, Karolina, 1959- (advisor).

Subjects/Keywords: Immunology. Cancer immunology. Melanoma. Tumor microenvironment. Quantitative imaging. Confocal microscopy. Laser capture micro dissection.

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APA (6^th Edition):

author], [. (2018). Quantitative cellular and molecular imaging of the intact tumor microenvironment. (Thesis). Baylor University. Retrieved from http://hdl.handle.net/2104/10436

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Quantitative cellular and molecular imaging of the intact tumor microenvironment. ” 2018. Thesis, Baylor University. Accessed December 10, 2019. http://hdl.handle.net/2104/10436.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Quantitative cellular and molecular imaging of the intact tumor microenvironment. ” 2018. Web. 10 Dec 2019.

Vancouver:

author] [. Quantitative cellular and molecular imaging of the intact tumor microenvironment. [Internet] [Thesis]. Baylor University; 2018. [cited 2019 Dec 10]. Available from: http://hdl.handle.net/2104/10436.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Quantitative cellular and molecular imaging of the intact tumor microenvironment. [Thesis]. Baylor University; 2018. Available from: http://hdl.handle.net/2104/10436

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Morgat, Clément. Imagerie des récepteurs de neuropeptides pour le ciblage tumoral : Neuropeptide receptors imaging for tumor targetin.

Degree: Docteur es, Bioimagerie, 2015, Bordeaux

URL: http://www.theses.fr/2015BORD0308

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Des récepteurs de neuropeptides peuvent être fortement exprimés à la surface descellules tumorales offrant ainsi l’opportunité de les visualiser en imagerie par Tomographie d'Emissionde Positons… (more)

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Des récepteurs de neuropeptides peuvent être fortement exprimés à la surface descellules tumorales offrant ainsi l’opportunité de les visualiser en imagerie par Tomographie d'Emissionde Positons (TEP) grâce à des analogues radiomarqués au 68Ga, 64Cu ou au 18F, mais également desélectionner des patients répondeurs à une radiothérapie métabolique à l'aide de ces mêmes analogues,radiomarqués au 177Lu ou 90Y. Un exemple phare a été le développement d’analogues radiomarqués dela somatostatine pour l'imagerie (68Ga-DOTATOC) et le traitement (177Lu-DOTATATE) des tumeursneuro-endocrines (TNE). Cette voie diagnostique et thérapeutique s’est récemment amplifiée avecl’identification d'autres neuropeptides et leurs récepteurs (sur)exprimés par les cellules tumorales. Cetravail de Thèse s'est donc déroulé selon plusieurs thématiques dont la première a été la mise en placed'une plate-forme de radiomarquage au 68Ga (une des premières en France) pour introduire l'imageriedes récepteurs somatostatine dans les TNE à Bordeaux (essai clinique GALTEP utilisant le 68Ga-DOTATOC) ou d'autres molécules innovantes (68Ga-PSMA dans le cancer de la prostate). Afind’envisager d'autres applications des récepteurs de la somatostatine nous avons recherché leurexpression dans des lymphomes de Hodgkin. Enfin, nous nous sommes concentrés sur ledéveloppement de deux autres familles de neuropeptides; les récepteurs de la bombésine (GRP-R etNMB-R) et de la neurotensine (NTR1). Nous avons finement caractérisé l'expression du GRP-R dansle cancer du sein et développé une nouvelle classe de radiopeptides pour le ciblage des récepteurs de labombésine. Enfin, nous avons étudié NTR1 dans diverses tumeurs pour fournir le rationnel nécessaireau développement d'analogues de la neurotensine.

Neuropeptide receptors can be highly expressed on the cell surface of tumor cells,paving the way to their visualization with Positron Emission Tomography (PET) using analoguesradiolabeled with 68Ga, 64Cu or 18F, but also to select patients who can benefit fromradiopharmaceutical therapy using similar analogues radiolabeled with 177Lu or 90Y. An example hasbeen the development of somatostatin radio-analogues for imaging (68Ga-DOTATOC) and therapy(177Lu-DOTATATE) of neuroendocrine tumors (NET). This concept has gained insight since thediscovery of other neuropeptides and their receptors (over)expressed on diverse tumors. This PhD hasbeen conducted according to several axis, the first being the establishment of a 68Ga-radiolabelingplatform (among the first in France) to introduce somatostatin receptor PET imaging of NET inBordeaux (clinical trial GALTEP using 68Ga-DOTATOC) but also other innovative molecules (68Ga-PSMA for prostate cancer imaging). Furthermore, to consider other applications of somatostatinreceptors we investigated their expression in Hodgkin's lymphomas. We then mainly aimed atinvestigating possibilities offered by two other families of neuropeptide receptors: bombesin receptors(GRP-R and NMB-R) and neurotensin receptors (NTR1). For the bombesin family, we have…

Advisors/Committee Members: Hindie, Elif (thesis director).

Subjects/Keywords: 68Ga; Neuropeptide; Cancer; Imagerie moléculaire; 68Ga; Neuropeptide; Cancer; Molecular imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Morgat, C. (2015). Imagerie des récepteurs de neuropeptides pour le ciblage tumoral : Neuropeptide receptors imaging for tumor targetin. (Doctoral Dissertation). Bordeaux. Retrieved from http://www.theses.fr/2015BORD0308

Chicago Manual of Style (16^th Edition):

Morgat, Clément. “Imagerie des récepteurs de neuropeptides pour le ciblage tumoral : Neuropeptide receptors imaging for tumor targetin.” 2015. Doctoral Dissertation, Bordeaux. Accessed December 10, 2019. http://www.theses.fr/2015BORD0308.

MLA Handbook (7^th Edition):

Morgat, Clément. “Imagerie des récepteurs de neuropeptides pour le ciblage tumoral : Neuropeptide receptors imaging for tumor targetin.” 2015. Web. 10 Dec 2019.

Vancouver:

Morgat C. Imagerie des récepteurs de neuropeptides pour le ciblage tumoral : Neuropeptide receptors imaging for tumor targetin. [Internet] [Doctoral dissertation]. Bordeaux; 2015. [cited 2019 Dec 10]. Available from: http://www.theses.fr/2015BORD0308.

Council of Science Editors:

Morgat C. Imagerie des récepteurs de neuropeptides pour le ciblage tumoral : Neuropeptide receptors imaging for tumor targetin. [Doctoral Dissertation]. Bordeaux; 2015. Available from: http://www.theses.fr/2015BORD0308

8. Bianchi, Andrea. Magnetic resonance imaging techniques for pre-clinical lung imaging : Techniques d’IRM pour l’imagerie préclinique du poumon.

Degree: Docteur es, Bioimagerie, 2014, Bordeaux

URL: http://www.theses.fr/2014BORD0060

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Dans ce travail, les s´séquences Imagerie par Résonance Magnétique (IRM) radiales à temps d’écho ultra-court (UTE) sont analysées pour évaluer leur potentiel dans l’étude non-invasive… (more)

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Dans ce travail, les s´séquences Imagerie par Résonance Magnétique (IRM) radiales à temps d’écho ultra-court (UTE) sont analysées pour évaluer leur potentiel dans l’étude non-invasive de différents modèles expérimentaux de maladies pulmonaires chez la souris. Chez le petit animal, les séquences radiales UTE peuvent efficacement limiter l’impact négatif sur la qualité de l’image dû au déphasage rapide des spins causé par les nombreuses interfaces air/tissu. En plus, les séquences radiales UTE sont moins sensibles aux artefacts de mouvement par rapport aux séquences Cartésiennes classiques. En conséquence, chez le petit animal, les séquences radiales UTE peuvent permettre d’obtenir des images du poumon avec une résolution bien inférieure au millimètre avec des rapports signal/bruit importants dans le parenchyme pulmonaire, tout en travaillant en conditions physiologiques (animaux en respiration spontanée). Dans cette thèse, il sera démontré que les séquences d’IRM protonique UTE sont outils efficaces dans l’étude quantitative et non-invasive de différents marqueurs distinctifs de certaines pathologies pulmonaires d’intérêt général. Les protocoles développés serontsimples, rapides et non-invasifs, faciles à implémenter, avec une interférence minimale sur la pathologie pulmonaire étudiée et, en définitive, potentiellement applicables chez l’homme. Il sera ainsi démontré que l’emploi des agents de contraste, administrés via les voies aériennes, permet d’augmenter la sensibilité des protocoles développés. Parallèlement, dans cette thèse des protocoles suffisamment flexibles seront implémentés afin de permettre l’étude d’un agent de contraste paramagnétique générique pour des applications aux poumons.

In this work, ultra-short echo time (UTE) Magnetic Resonance Imaging (MRI) sequences are investigated as flexible tools for the noninvasive study of experimental models of lung diseases in mice. In small animals radial UTE sequences can indeed efficiently limit the negative impact on lung image quality due to the fast spin dephasing caused by the multiple air/tissue interfaces. In addition, radial UTE sequences are less sensitive to motion artifacts compared to standard Cartesian acquisitions. As a result, radial UTE acquisitions can provide lung images in small animals at sub-millimetric resolution with significant signal to noise ratio in the lung parenchyma, while working with physiological conditions (freely-breathing animals). In this thesis, UTE proton MRI sequences were shown to be efficient instruments to quantitatively investigate a number of hallmarks in longitudinal models of relevant lung diseases with minimal interference with the lung pathophysiology, employing easilyimplementable fast protocols. The synergic use of positive contrast agents, along with anadvantageous administration modality, was shown to be a valuable help in the increase of sensitivity of UTE MRI. At the same time, UTE MRI was shown to be an extremely useful and efficacious sequence for studying positive contrast agents in lungs

Advisors/Committee Members: Crémillieux, Yannick (thesis director).

Subjects/Keywords: Poumon; Imagerie par Résonance Magnétique; Temps d’écho ultra-court; IRM UTE; Asthme; Cancer du poumon; Agents de contraste; Nanoparticules à base de gadolinium; Imagerie optique; Modèles animaux; Lung; Magnetic Resonance Imaging; Ultra-short echo time; UTE MRI; Asthma; Lung cancer; Contrast agents; Gadolinium nanoparticles; Optical imaging; Mice models

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bianchi, A. (2014). Magnetic resonance imaging techniques for pre-clinical lung imaging : Techniques d’IRM pour l’imagerie préclinique du poumon. (Doctoral Dissertation). Bordeaux. Retrieved from http://www.theses.fr/2014BORD0060

Chicago Manual of Style (16^th Edition):

Bianchi, Andrea. “Magnetic resonance imaging techniques for pre-clinical lung imaging : Techniques d’IRM pour l’imagerie préclinique du poumon.” 2014. Doctoral Dissertation, Bordeaux. Accessed December 10, 2019. http://www.theses.fr/2014BORD0060.

MLA Handbook (7^th Edition):

Bianchi, Andrea. “Magnetic resonance imaging techniques for pre-clinical lung imaging : Techniques d’IRM pour l’imagerie préclinique du poumon.” 2014. Web. 10 Dec 2019.

Vancouver:

Bianchi A. Magnetic resonance imaging techniques for pre-clinical lung imaging : Techniques d’IRM pour l’imagerie préclinique du poumon. [Internet] [Doctoral dissertation]. Bordeaux; 2014. [cited 2019 Dec 10]. Available from: http://www.theses.fr/2014BORD0060.

Council of Science Editors:

Bianchi A. Magnetic resonance imaging techniques for pre-clinical lung imaging : Techniques d’IRM pour l’imagerie préclinique du poumon. [Doctoral Dissertation]. Bordeaux; 2014. Available from: http://www.theses.fr/2014BORD0060

Boston University

9. Baker, Adam Timothy. Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer.

Degree: MS, Bioimaging, 2018, Boston University

URL: http://hdl.handle.net/2144/33003

► The extension from Quantitative Magnetic Resonance Imaging to synthetic imaging has the clear advantage of being able to continually image the patient after the exam.… (more)

Subjects/Keywords: Medical imaging; Diffusion weighted imaging; Contrast-to-noise; Prostate cancer; Quantitative magnetic resonance imaging; Signal-to-noise; Synthetic magnetic resonance imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Baker, A. T. (2018). Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/33003

Chicago Manual of Style (16^th Edition):

Baker, Adam Timothy. “Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer.” 2018. Masters Thesis, Boston University. Accessed December 10, 2019. http://hdl.handle.net/2144/33003.

MLA Handbook (7^th Edition):

Baker, Adam Timothy. “Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer.” 2018. Web. 10 Dec 2019.

Vancouver:

Baker AT. Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer. [Internet] [Masters thesis]. Boston University; 2018. [cited 2019 Dec 10]. Available from: http://hdl.handle.net/2144/33003.

Council of Science Editors:

Baker AT. Image quality of standard and synthetic diffusion weighted magnetic resonance imaging in prostate cancer. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/33003

Boston University

10. Patel, Kunal. Quantitative analysis of breast lumpectomies using histology and micro-CT data.

Degree: MS, Medical Sciences, 2014, Boston University

URL: http://hdl.handle.net/2144/14394

► OBJECTIVE: Breast cancer represents a significant risk in women's health, affecting many women worldwide. Current treatment options in the U.S involve a multidisciplinary approach, most… (more)

Subjects/Keywords: Medical imaging; Lumpectomy; Micro-CT; Breast cancer; Breast radiodensity; Margin assessment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patel, K. (2014). Quantitative analysis of breast lumpectomies using histology and micro-CT data. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14394

Chicago Manual of Style (16^th Edition):

Patel, Kunal. “Quantitative analysis of breast lumpectomies using histology and micro-CT data.” 2014. Masters Thesis, Boston University. Accessed December 10, 2019. http://hdl.handle.net/2144/14394.

MLA Handbook (7^th Edition):

Patel, Kunal. “Quantitative analysis of breast lumpectomies using histology and micro-CT data.” 2014. Web. 10 Dec 2019.

Vancouver:

Patel K. Quantitative analysis of breast lumpectomies using histology and micro-CT data. [Internet] [Masters thesis]. Boston University; 2014. [cited 2019 Dec 10]. Available from: http://hdl.handle.net/2144/14394.

Council of Science Editors:

Patel K. Quantitative analysis of breast lumpectomies using histology and micro-CT data. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14394

Boston University

11. Sarraj, Wafa Mowafak. Micro computed tomography assessment of tumor size in breast cancer compared to histopathological examination.

Degree: MS, Clinical Investigation, 2014, Boston University

URL: http://hdl.handle.net/2144/15353

► PURPOSE: The purpose of this study was to assess the ability of Micro Computed Tomography (Micro CT) to measure primary tumor size in breast lumpectomy… (more)

Subjects/Keywords: Oncology; Breast cancer; Breast cancer staging; Breast imaging; Gross pathology; Micro CT; Tumor size

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sarraj, W. M. (2014). Micro computed tomography assessment of tumor size in breast cancer compared to histopathological examination. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/15353

Chicago Manual of Style (16^th Edition):

Sarraj, Wafa Mowafak. “Micro computed tomography assessment of tumor size in breast cancer compared to histopathological examination.” 2014. Masters Thesis, Boston University. Accessed December 10, 2019. http://hdl.handle.net/2144/15353.

MLA Handbook (7^th Edition):

Sarraj, Wafa Mowafak. “Micro computed tomography assessment of tumor size in breast cancer compared to histopathological examination.” 2014. Web. 10 Dec 2019.

Vancouver:

Sarraj WM. Micro computed tomography assessment of tumor size in breast cancer compared to histopathological examination. [Internet] [Masters thesis]. Boston University; 2014. [cited 2019 Dec 10]. Available from: http://hdl.handle.net/2144/15353.

Council of Science Editors:

Sarraj WM. Micro computed tomography assessment of tumor size in breast cancer compared to histopathological examination. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/15353

Brno University of Technology

12. Valášek, Jiří. Biomechanická studie obličejového skeletu .

Degree: Brno University of Technology

URL: http://hdl.handle.net/11012/63128

► Předložená práce je biomechanickou studií obličejového skeletu se zaměřením na fixaci dolní čelisti po odstranění nádorového onemocnění dolní čelisti. Cílem práce je provedení biomechanické studie… (more)

▼ Předložená práce je biomechanickou studií obličejového skeletu se zaměřením na fixaci dolní čelisti po odstranění nádorového onemocnění dolní čelisti. Cílem práce je provedení biomechanické studie obličejového skeletu s následnou detailní deformačně napěťovou analýzou dvou čelistních dlah navržených a vyrobených pro konkrétní pacienty. Geometrie dolní čelisti pro konstrukční návrh dlah a pro vytvoření modelu geometrie výpočtového modelu byla získaná na základě dat získaných z CT vyšetření dvou pacientů. Součástí dizertační práce je dílčí klinicko-teoretická studie, která se zabývá srovnáním zpracování informací z CT na data potřebná k tvorbě modelu geometrie. V rámci této práce byly vytvořeny výpočtové modely a provedena řešení deformace a napjatosti dolní čelisti s deficitem kostní tkáně fixované dlahou. Modely dolní čelisti včetně dlah byly vytvořeny pro konkrétní pacienty s nádorovým onemocněním dolní čelisti. V závěrečných kapitolách dizertační práce jsou prezentována řešení deformace a napjatosti řešených čelistí s dlahou a analýza výsledků. Poznatky získané na základě provedené studie byly publikovány a aplikovány v klinické praxi.; Presented work deals with Biomechanical study of the facial skeleton. This work is focused on the fixation of the mandible after removal of a tumor from affected bone tissue. The aim of the work is to perform biomechanical study of the facial skeleton with subsequent detailed stress strain analysis of two mandible implants designed and manufactured for specific patients. The geometry model of mandible used for design of mandible implants and used for computational modelling has been obtained on the basis of CT data of two patients. A Theoretical-Clinical sub-study that deals with the comparison the CT data processing which is necessary for creating the model of geometry is a part of the thesis. Two models of mandible with applied mandible implant have been created for two specific patients with tumorous mandible bone tissue. Stress strain analysis has been performed for these two models. Results of the stress strain analysis of two models of mandibles with mandible implants are presented in the final chapters of the thesis. Findings of the biomechanical study have been published and applied in clinical practice. Advisors/Committee Members: Florian, Zdeněk (advisor).

Subjects/Keywords: Patient Specific modelování; výpočtové modelování; deformačně napěťová analýza; dolní čelist; nádorové onemocnění; kortikální kostní tkáň; spongiózní kostní tkáň; fixační dlaha pro konkrétního pacienta; zobrazovací metody; CT snímek; zpracování obrazu; nepřesnosti při tvorbě patient specific modelů; Patient Specific modeling; computational modeling; stress strain analysis; lower jaw; mandible; cancer; cortical bone tissue; cancellous bone tissue; patient specific implant; imaging methods; CT image; image processing; inaccuracies in the patient specific modeling

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Valášek, J. (n.d.). Biomechanická studie obličejového skeletu . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/63128

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Valášek, Jiří. “Biomechanická studie obličejového skeletu .” Thesis, Brno University of Technology. Accessed December 10, 2019. http://hdl.handle.net/11012/63128.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Valášek, Jiří. “Biomechanická studie obličejového skeletu .” Web. 10 Dec 2019.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Valášek J. Biomechanická studie obličejového skeletu . [Internet] [Thesis]. Brno University of Technology; [cited 2019 Dec 10]. Available from: http://hdl.handle.net/11012/63128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Valášek J. Biomechanická studie obličejového skeletu . [Thesis]. Brno University of Technology; Available from: http://hdl.handle.net/11012/63128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Brno University of Technology

13. Valášek, Jiří. Biomechanická studie obličejového skeletu .

Degree: 2016, Brno University of Technology

URL: http://hdl.handle.net/11012/63143

► Předložená práce je biomechanickou studií obličejového skeletu se zaměřením na fixaci dolní čelisti po odstranění nádorového onemocnění dolní čelisti. Cílem práce je provedení biomechanické studie… (more)

▼ Předložená práce je biomechanickou studií obličejového skeletu se zaměřením na fixaci dolní čelisti po odstranění nádorového onemocnění dolní čelisti. Cílem práce je provedení biomechanické studie obličejového skeletu s následnou detailní deformačně napěťovou analýzou dvou čelistních dlah navržených a vyrobených pro konkrétní pacienty. Geometrie dolní čelisti pro konstrukční návrh dlah a pro vytvoření modelu geometrie výpočtového modelu byla získaná na základě dat získaných z CT vyšetření dvou pacientů. Součástí dizertační práce je dílčí klinicko-teoretická studie, která se zabývá srovnáním zpracování informací z CT na data potřebná k tvorbě modelu geometrie. V rámci této práce byly vytvořeny výpočtové modely a provedena řešení deformace a napjatosti dolní čelisti s deficitem kostní tkáně fixované dlahou. Modely dolní čelisti včetně dlah byly vytvořeny pro konkrétní pacienty s nádorovým onemocněním dolní čelisti. V závěrečných kapitolách dizertační práce jsou prezentována řešení deformace a napjatosti řešených čelistí s dlahou a analýza výsledků. Poznatky získané na základě provedené studie byly publikovány a aplikovány v klinické praxi.; Presented work deals with Biomechanical study of the facial skeleton. This work is focused on the fixation of the mandible after removal of a tumor from affected bone tissue. The aim of the work is to perform biomechanical study of the facial skeleton with subsequent detailed stress strain analysis of two mandible implants designed and manufactured for specific patients. The geometry model of mandible used for design of mandible implants and used for computational modelling has been obtained on the basis of CT data of two patients. A Theoretical-Clinical sub-study that deals with the comparison the CT data processing which is necessary for creating the model of geometry is a part of the thesis. Two models of mandible with applied mandible implant have been created for two specific patients with tumorous mandible bone tissue. Stress strain analysis has been performed for these two models. Results of the stress strain analysis of two models of mandibles with mandible implants are presented in the final chapters of the thesis. Findings of the biomechanical study have been published and applied in clinical practice. Advisors/Committee Members: Florian, Zdeněk (advisor).

Subjects/Keywords: Patient Specific modelování; výpočtové modelování; deformačně napěťová analýza; dolní čelist; nádorové onemocnění; kortikální kostní tkáň; spongiózní kostní tkáň; fixační dlaha pro konkrétního pacienta; zobrazovací metody; CT snímek; zpracování obrazu; nepřesnosti při tvorbě patient specific modelů; Patient Specific modeling; computational modeling; stress strain analysis; lower jaw; mandible; cancer; cortical bone tissue; cancellous bone tissue; patient specific implant; imaging methods; CT image; image processing; inaccuracies in the patient specific modeling

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Valášek, J. (2016). Biomechanická studie obličejového skeletu . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/63143

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Valášek, Jiří. “Biomechanická studie obličejového skeletu .” 2016. Thesis, Brno University of Technology. Accessed December 10, 2019. http://hdl.handle.net/11012/63143.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Valášek, Jiří. “Biomechanická studie obličejového skeletu .” 2016. Web. 10 Dec 2019.

Vancouver:

Valášek J. Biomechanická studie obličejového skeletu . [Internet] [Thesis]. Brno University of Technology; 2016. [cited 2019 Dec 10]. Available from: http://hdl.handle.net/11012/63143.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Valášek J. Biomechanická studie obličejového skeletu . [Thesis]. Brno University of Technology; 2016. Available from: http://hdl.handle.net/11012/63143

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

14. Plišková, Diana. Nové nádorové biomarkery odvozené z kvantitativního fázového zobrazování buněk .

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/173646

► Hlavným cieľom tejto práce je vývoj nových nádorových biomarkerov využiteľných v perzonalizovaných liečbach. Pre pochopenie, prečo je táto problematika dôležitá, slúži stručný popis rakoviny obsahujúcej… (more)

Subjects/Keywords: rakovina; kvantitatívne fázové zobrazovanie; svetelná mikroskopia; analýza variancie; spracovanie obrazov; analýza hlavných komponent; biomarker; cancer; quantitative phase imaging; light microscopy; analysis of variance; image processing; principal component analysis; biomarker

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Plišková, D. (2019). Nové nádorové biomarkery odvozené z kvantitativního fázového zobrazování buněk . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/173646

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Plišková, Diana. “Nové nádorové biomarkery odvozené z kvantitativního fázového zobrazování buněk .” 2019. Thesis, Brno University of Technology. Accessed December 10, 2019. http://hdl.handle.net/11012/173646.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Plišková, Diana. “Nové nádorové biomarkery odvozené z kvantitativního fázového zobrazování buněk .” 2019. Web. 10 Dec 2019.

Vancouver:

Plišková D. Nové nádorové biomarkery odvozené z kvantitativního fázového zobrazování buněk . [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2019 Dec 10]. Available from: http://hdl.handle.net/11012/173646.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Plišková D. Nové nádorové biomarkery odvozené z kvantitativního fázového zobrazování buněk . [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/173646

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brunel University

15. Al Zu'bi, Shadi Mahmoud. 3D multiresolution statistical approaches for accelerated medical image and volume segmentation.

Degree: PhD, 2011, Brunel University

URL: http://bura.brunel.ac.uk/handle/2438/5300 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535950

► Medical volume segmentation got the attraction of many researchers; therefore, many techniques have been implemented in terms of medical imaging including segmentations and other imaging… (more)

▼ Medical volume segmentation got the attraction of many researchers; therefore, many techniques have been implemented in terms of medical imaging including segmentations and other imaging processes. This research focuses on an implementation of segmentation system which uses several techniques together or on their own to segment medical volumes, the system takes a stack of 2D slices or a full 3D volumes acquired from medical scanners as a data input. Two main approaches have been implemented in this research for segmenting medical volume which are multi-resolution analysis and statistical modeling. Multi-resolution analysis has been mainly employed in this research for extracting the features. Higher dimensions of discontinuity (line or curve singularity) have been extracted in medical images using a modified multi-resolution analysis transforms such as ridgelet and curvelet transforms. The second implemented approach in this thesis is the use of statistical modeling in medical image segmentation; Hidden Markov models have been enhanced here to segment medical slices automatically, accurately, reliably and with lossless results. But the problem with using Markov models here is the computational time which is too long. This has been addressed by using feature reduction techniques which has also been implemented in this thesis. Some feature reduction and dimensionality reduction techniques have been used to accelerate the slowest block in the proposed system. This includes Principle Components Analysis, Gaussian Pyramids and other methods. The feature reduction techniques have been employed efficiently with the 3D volume segmentation techniques such as 3D wavelet and 3D Hidden Markov models. The system has been tested and validated using several procedures starting at a comparison with the predefined results, crossing the specialists’ validations, and ending by validating the system using a survey filled by the end users explaining the techniques and the results. This concludes that Markovian models segmentation results has overcome all other techniques in most patients’ cases. Curvelet transform has been also proved promising segmentation results; the end users rate it better than Markovian models due to the long time required with Hidden Markov models.

Subjects/Keywords: 615.84; Medical imaging; Segmentation; Image processing; Multiresolution analysis; Cancer detection

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APA (6^th Edition):

Al Zu'bi, S. M. (2011). 3D multiresolution statistical approaches for accelerated medical image and volume segmentation. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/5300 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535950

Chicago Manual of Style (16^th Edition):

Al Zu'bi, Shadi Mahmoud. “3D multiresolution statistical approaches for accelerated medical image and volume segmentation.” 2011. Doctoral Dissertation, Brunel University. Accessed December 10, 2019. http://bura.brunel.ac.uk/handle/2438/5300 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535950.

MLA Handbook (7^th Edition):

Al Zu'bi, Shadi Mahmoud. “3D multiresolution statistical approaches for accelerated medical image and volume segmentation.” 2011. Web. 10 Dec 2019.

Vancouver:

Al Zu'bi SM. 3D multiresolution statistical approaches for accelerated medical image and volume segmentation. [Internet] [Doctoral dissertation]. Brunel University; 2011. [cited 2019 Dec 10]. Available from: http://bura.brunel.ac.uk/handle/2438/5300 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535950.

Council of Science Editors:

Al Zu'bi SM. 3D multiresolution statistical approaches for accelerated medical image and volume segmentation. [Doctoral Dissertation]. Brunel University; 2011. Available from: http://bura.brunel.ac.uk/handle/2438/5300 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535950

Case Western Reserve University

16. Foy, Susan Patricia. Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy.

Degree: PhD, Molecular Medicine, 2012, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1319836040

► Tumor heterogeneity can significantly influence the efficacy of cancer chemotherapy and nanoparticle-mediated drug delivery. Therefore, there is a need of multifunctional nanoparticles that can… (more)

▼ Tumor heterogeneity can significantly influence the efficacy of cancer chemotherapy and nanoparticle-mediated drug delivery. Therefore, there is a need of multifunctional nanoparticles that can deliver therapeutics and be tracked longitudinally. The research described in this thesis explores magnetic nanoparticles for applications in tumor identification, monitoring nanoparticle biodistribution, and cancer therapy. The multifunctional formulation can potentially be used in image-guided drug therapy to enhance diagnostic procedures and therapeutic outcomes. The magnetic nanoparticle formulation consists of an iron-oxide magnetic core coated with oleic acid then stabilized with an amphiphilic block copolymer. Magnetic nanoparticles coated with the copolymer Pluronic F127 demonstrate sustained and enhanced magnetic resonance contrast in the whole tumor of a mouse breast xenograft tumor model. Hydrophobic near infrared dyes were loaded into the oleic acid coating of the magnetic nanoparticles to quantitatively determine their long-term biodistribution in vivo. The magnetic nanoparticles are visible in orthotopic breast tumors up to 12 days post-injection through in vivo fluorescence imaging. One-hour exposure to a magnetic field further enhances magnetic nanoparticle localization to the tumors. The anticancer drugs doxorubicin and paclitaxel were loaded into the oleic acid layer of the magnetic nanoparticles for therapeutic treatment of breast cancer. Drug loaded magnetic nanoparticles effectively treat breast cancer cells in vitro, while plain magnetic nanoparticles are non-toxic. Both plain and drug loaded magnetic nanoparticles significantly decrease tumor size and increase survival in tumor bearing mice compared to saline controls. Plain magnetic nanoparticles localized in the tumor as they breakdown may generate reactive oxygen species due to the Fenton reaction, causing apoptosis of cancer cells and leading to therapeutic effect without drug. The magnetic nanoparticleshave the potential to be developed as an effective cancer theranostic agent, i.e., an agent with combined imaging and therapeutic applications. Advisors/Committee Members: Flask, Christopher (Committee Chair), Budd, G. Thomas (Advisor), Labhasetwar, Vinod (Advisor).

Subjects/Keywords: Biomedical Engineering; Biomedical Research; Nanoscience; Nanotechnology; Oncology; magnetic nanoparticles; magnetic resonance imaging; optical imaging; NIR dyes; drug delivery; Doxorubicin; Paclitaxel; iron-oxide; Fenton reaction; cancer

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APA (6^th Edition):

Foy, S. P. (2012). Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1319836040

Chicago Manual of Style (16^th Edition):

Foy, Susan Patricia. “Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy.” 2012. Doctoral Dissertation, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1319836040.

MLA Handbook (7^th Edition):

Foy, Susan Patricia. “Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy.” 2012. Web. 10 Dec 2019.

Vancouver:

Foy SP. Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2012. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1319836040.

Council of Science Editors:

Foy SP. Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy. [Doctoral Dissertation]. Case Western Reserve University; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1319836040

17. Ginsburg, Shoshana. Machine-Based Interpretation and Classification of Image-Derived Features: Applications in Digital Pathology and Multi-Parametric MRI of Prostate Cancer.

Degree: PhD, Biomedical Engineering, 2016, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1459116552

► The analysis of medical images – from magnetic resonance imaging (MRI) to digital pathology – for disease characterization typically involves extraction of hundreds of features, which may… (more)

Subjects/Keywords: Biomedical Engineering; Medical Imaging; Radiology; Prostate cancer; MRI; computer-aided diagnosis; dimensionality reduction

11 more images…

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APA (6^th Edition):

Ginsburg, S. (2016). Machine-Based Interpretation and Classification of Image-Derived Features: Applications in Digital Pathology and Multi-Parametric MRI of Prostate Cancer. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1459116552

Chicago Manual of Style (16^th Edition):

Ginsburg, Shoshana. “Machine-Based Interpretation and Classification of Image-Derived Features: Applications in Digital Pathology and Multi-Parametric MRI of Prostate Cancer.” 2016. Doctoral Dissertation, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1459116552.

MLA Handbook (7^th Edition):

Ginsburg, Shoshana. “Machine-Based Interpretation and Classification of Image-Derived Features: Applications in Digital Pathology and Multi-Parametric MRI of Prostate Cancer.” 2016. Web. 10 Dec 2019.

Vancouver:

Ginsburg S. Machine-Based Interpretation and Classification of Image-Derived Features: Applications in Digital Pathology and Multi-Parametric MRI of Prostate Cancer. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2016. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1459116552.

Council of Science Editors:

Ginsburg S. Machine-Based Interpretation and Classification of Image-Derived Features: Applications in Digital Pathology and Multi-Parametric MRI of Prostate Cancer. [Doctoral Dissertation]. Case Western Reserve University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1459116552

Case Western Reserve University

18. Liu, Guanshu. DEVELOPMENT OF PARACEST MRI TO DETECT CANCER BIOMARKERS.

Degree: PhD, Biomedical Engineering, 2008, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1199932704

► Molecular imaging has become one of the most significant developments in MRI in the last decade with dramatic impacts for disease diagnosis and therapy. A… (more)

▼ Molecular imaging has become one of the most significant developments in MRI in the last decade with dramatic impacts for disease diagnosis and therapy. A novel MRI contrast strategy named PARAmagnetic Chemical Exchange Saturation Transfer(PARACEST) can exploit the NMR chemical shift to selectively detect molecular biomarkers, while retaining the sensitivity and spatial resolution of MRI. The development of this novel approach for cancer biomarker detection is described in the following chapters. Chapter 1: Background information is presented about the relevance of biomarker detection by molecular imaging and MRI molecular imaging. The mechanisms of MRI contrast agent including T ₁contrast agents, T ₂/T ₂* contrast agents and CEST/PARACEST contrast agents are introduced. The PARACEST contrast mechanism is then emphasized for the potential biomedical applications. Chapter 2: A new irreversible nitric oxide (NO) responsive PARACEST MRI contrast agent, Yb-DO3oAA, has been designed, synthesized and characterized. The PARACEST effects have been investigated with respect to pH, temperature, and concentration for the in vivoapplicability. The ability to detect NO has been demonstrated in vitro. Chapter 3: A new MRI method has been developed for assessing in vivo pH by using a PARACEST MRI contrast agent Yb-DO3AoAA. A ratiometric approach has been employed based on the two intra-molecular PARACEST signals. Our study has demonstrated that this method can be used for measuring extracellular pH within in vivo animal models without the need for a second “control” agent. Chapter 4: New MRI pulse sequences have been developed to address the poor temporal resolution challenges for the in vivoapplications of PARACEST agents. Different strategies have been developed for the applications in different in vivo environments. These new MRI methods have been developed for high field small animal studies and tested both within in vitroand in vivomodels. Chapter 5: The major drawbacks and technical hurdles in PARACEST studies are presented and followed by the discussion of future developments. A number of potential projects thereby are proposed as future studies. Advisors/Committee Members: Pagel, Mark (Advisor).

Subjects/Keywords: Engineering, Biomedical; MRI; molecular imaging; contrast agent; PARACEST; cancer biomarker

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APA (6^th Edition):

Liu, G. (2008). DEVELOPMENT OF PARACEST MRI TO DETECT CANCER BIOMARKERS. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1199932704

Chicago Manual of Style (16^th Edition):

Liu, Guanshu. “DEVELOPMENT OF PARACEST MRI TO DETECT CANCER BIOMARKERS.” 2008. Doctoral Dissertation, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1199932704.

MLA Handbook (7^th Edition):

Liu, Guanshu. “DEVELOPMENT OF PARACEST MRI TO DETECT CANCER BIOMARKERS.” 2008. Web. 10 Dec 2019.

Vancouver:

Liu G. DEVELOPMENT OF PARACEST MRI TO DETECT CANCER BIOMARKERS. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2008. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1199932704.

Council of Science Editors:

Liu G. DEVELOPMENT OF PARACEST MRI TO DETECT CANCER BIOMARKERS. [Doctoral Dissertation]. Case Western Reserve University; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1199932704

Case Western Reserve University

19. FEI, Baowei. Image Registration for the Prostate.

Degree: PhD, EECS - System and Control Engineering, 2008, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1224274091

► The long-term goal of this research is to develop medical image registration techniques that can improve cancer detection, diagnosis, and therapy. Both rigid-body and deformable… (more)

▼ The long-term goal of this research is to develop medical image registration techniques that can improve cancer detection, diagnosis, and therapy. Both rigid-body and deformable image registration methods were developed for human magnetic resonance (MR) images. As reported in Chapter 2, our automatic, three-dimensional (3D), rigid-body registration method has special features that include multi-resolution, multi-similarity, and restarting mechanisms. These features improved the robustness of MR image registration. The automatic registration method has been evaluated for potential applications in prostate MR imaging. However, tissue deformation and patient positions often raise problems for rigid-body registration. In order to improve registration accuracy, 3D thin-plate spline (TPS)-based deformable registration methods were developed and evaluated for pelvic MR images that were acquired at different patient positions/conditions. As described in Chapter 3, our TPS registration methods have several potential applications for image-guided therapy of the prostate. With the recent advancement of small animal imaging technology, MR imaging can provide high-resolution images of a tumor with subtle anatomic details, molecular imaging such as positron emission tomography (PET) can provide functional and metabolic information regarding the tumor. Registration of PET and MR images can combine the strength from the two imaging modalities and thus provides complementary information at the cellular and molecular levels. Chapter 4 proposes and evaluates a finite-element model (FEM)-based registration method for tumor PET and MR images, which can have unique applications in cancer early detection and therapy assessment. Chapter 5 further demonstrates clinical applications of multimodality image registration for prostate cancer patients. Methods were developed for MRI/SPECT registration and CT/SPECT fusion. Finally, Chapter 6 describes the future work of image registration techniques and the conclusion of the research work. Advisors/Committee Members: Loparo, Kenneth (Committee Chair).

Subjects/Keywords: Computer Science; Engineering; Radiology; Scientific Imaging; image registration; deformable registration; non-rigid registration; thin plate spline; finite element model; prostate cancer; image-guided therapy; magnetic resonance imaging (MRI); positron emission tomography (PET); molecular imaging

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APA (6^th Edition):

FEI, B. (2008). Image Registration for the Prostate. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1224274091

Chicago Manual of Style (16^th Edition):

FEI, Baowei. “Image Registration for the Prostate.” 2008. Doctoral Dissertation, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1224274091.

MLA Handbook (7^th Edition):

FEI, Baowei. “Image Registration for the Prostate.” 2008. Web. 10 Dec 2019.

Vancouver:

FEI B. Image Registration for the Prostate. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2008. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1224274091.

Council of Science Editors:

FEI B. Image Registration for the Prostate. [Doctoral Dissertation]. Case Western Reserve University; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1224274091

Case Western Reserve University

20. Kuang, Yu. Positron Emission Tomography Imaging of Hepatocellular Carcinoma with Radiolabeled Choline.

Degree: PhD, Biomedical Engineering, 2009, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1238781224

► Hepatocellular Carcinoma (HCC) is one of the most common malignancies throughout the world and its five-year survival rate has been dismal (5%). The carcinogenesis is… (more)

▼ Hepatocellular Carcinoma (HCC) is one of the most common malignancies throughout the world and its five-year survival rate has been dismal (5%). The carcinogenesis is frequently associated with the metabolic changes that precede the morphological changes. Therefore, a non-invasive, fast, quantitative technique for detection of HCC is much needed. Positron emission tomography (PET), a molecular imaging technique, holds particular promise for diagnostic imaging of neoplasms. The focus of this thesis is on the diagnostic utility of PET metabolic imaging on HCC and the mechanisms underlying the imaging using radiolabeled choline (CHOL) as the tracer. (1) Many cancers display a high rate of aerobic glycolysis, a phenomenon that is exploited by 2-Deoxy-2-[¹⁸F]-fluoro-D-glucose (FDG) PET imaging for the detection of tumors. Up-regulation of glycolytic metabolism plays a role in tumor progression by contributing to tumor growth or survival. In this study, the usefulness of FDG-PET for HCC was investigated. The study addressed the correlation between FDG-PET images with pathologic types of HCC. The overall sensitivity of FDG-PET in the detection of HCC is low (50-55%). This can be explained by the wide variability in enzyme activity in the individual HCC. In well-differentiated HCC, FDG metabolism may be similar to that of the surrounding liver, leading to a false negative result, while higher sensitivity was reported in poorly differentiated HCC. (2) Increased lipid synthesis is required by a growing tumor cell to synthesize membranes and lipid-modified signaling molecules. The radiolabeled choline (CHOL) was used to probe lipid synthesis in HCC. In this study, PET/CT imaging was correlated with metabolites analysis in vivo and in vitro, which helps to explain the heterogenous uptake of radiolabeled CHOL in HCC. Transport and phosphorylation of CHOL are responsible for the tracer accumulation during [¹¹C]-CHOL PET imaging in well-differentiated HCC. Moreover, basal oxidation and phosphorylation activities in surrounding hepatic tissue contribute to the background signal seen in [¹¹C]-CHOL PET images. Furthermore, PET imaging of lipid synthesis with radiolabeled CHOL is useful in well-differentiated HCC that is not FDG avid. PET/CT imaging with radiolabeled CHOL could thus be a very promising diagnostic tool in patients with suspicious liver masses. Advisors/Committee Members: Wilson, David (Committee Chair), Lee, Zhenghong (Advisor).

Subjects/Keywords: Biochemistry; Engineering; Health; Radiology; Scientific Imaging; Hepatocellular Carcinoma; Positron Emission Tomography (PET); [<; sup>; 11<; /sup>; C]-choline; Molecular imaging; FDG; Cancer Metabolism; Transport mechanism; Phosphatidylcholine synthesis; Lipids; High performance liquid chromatography

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APA (6^th Edition):

Kuang, Y. (2009). Positron Emission Tomography Imaging of Hepatocellular Carcinoma with Radiolabeled Choline. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1238781224

Chicago Manual of Style (16^th Edition):

Kuang, Yu. “Positron Emission Tomography Imaging of Hepatocellular Carcinoma with Radiolabeled Choline.” 2009. Doctoral Dissertation, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1238781224.

MLA Handbook (7^th Edition):

Kuang, Yu. “Positron Emission Tomography Imaging of Hepatocellular Carcinoma with Radiolabeled Choline.” 2009. Web. 10 Dec 2019.

Vancouver:

Kuang Y. Positron Emission Tomography Imaging of Hepatocellular Carcinoma with Radiolabeled Choline. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2009. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1238781224.

Council of Science Editors:

Kuang Y. Positron Emission Tomography Imaging of Hepatocellular Carcinoma with Radiolabeled Choline. [Doctoral Dissertation]. Case Western Reserve University; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1238781224

21. Toy, Randall. The Effect of Particle Size and Shape on the In Vivo Journey of Nanoparticles.

Degree: PhD, Biomedical Engineering, 2014, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1396887959

► Although several formulations of nanomedicines are approved to treat cancer, their therapeutic efficacy has been limited in the clinic. The delivery of nanoparticles, which is… (more)

▼ Although several formulations of nanomedicines are approved to treat cancer, their therapeutic efficacy has been limited in the clinic. The delivery of nanoparticles, which is driven by blood flow, is hindered by high interstitial pressures in primary tumors. Moreover, clinically approved nanoparticles are not well designed to target metastasis, which is the leading cause of death from cancer. To effectively treat tumors, it is essential to improve a nanoparticle's ability to marginate (drift) to the blood vessel wall, overcome interstitial pressures, and bind to overexpressed receptors at a tumor. We assert that nanoparticle size and shape are both design parameters which must be optimized to target and treat tumors effectively. Shape, in particular, heavily influences a nanoparticle's pharmacokinetics, margination, and binding avidity to receptors. To evaluate the effect of size and shape on nanoparticle margination, the wall deposition of different classes of nanoparticles was compared under flow in a microfluidic chamber. With the knowledge that flow influences nanoparticle intravascular transport, we then employed an in vivo multimodal imaging protocol to evaluate the effect of blood flow on the intratumoral deposition of untargeted and targeted nanoparticles of unique sizes. These studies established that convection heavily influences the deposition of large nanoparticles, while active targeting to cell receptors improves the retention of smaller nanoparticles. Furthermore, these studies allowed us to derive design rules to improve the site-specific performance of nanoparticles for hard-to-treat cancers. For example, in contrast to primary tumors, micrometastatic lesions lack the hyperpermeable vasculature that allows nanoparticles to passively accumulate in the tumor interstitium. Thus, we developed a chain of iron oxide nanoparticles targeted to the alpha-v-beta-3 integrin, which is overexpressed on the vascular wall in metastatic lesions. The chain-shaped nanoparticle was identified to have high margination behavior and binding avidity, which enabled it to detect liver and lung micrometastases in a metastatic breast tumor model. Attachment of a doxorubicin liposome to the nanochain and use of a radiofrequency triggered drug release mechanism created an approach to treat metastatic breast cancer. This work demonstrates that rational selection of a nanoparticle's size and shape can positively impact the efficacy of nanoparticle chemotherapies against the aggressive forms of cancer. Advisors/Committee Members: Basilion, James (Committee Chair), Karathanasis, Efstathios (Advisor).

Subjects/Keywords: Biomedical Engineering; Nanotechnology; nanoparticle, size, shape, triple-negative breast cancer, metastasis, margination, nanochain, liposomes, blood flow, multi-modal imaging, tumor deposition, integrin, triggered drug release, chemotherapy

…angiogram using nCE-µCT �� ….67 viii Figure 4.3. Example of longitudinal imaging of the… …72 Figure 4.5. Multimodal in vivo imaging of vasculature, vascular permeability, integrin… …Figure 6.4. Multimodal whole body in vivo imaging and organ ex vivo imaging ��..116 Figure 6.5… …Treatment of breast cancer metastasis using the 4T1 mammary model in mice… …Case Center for Imaging Research, including Dr. Chris Flask, Joseph Molter, and Bernadette…

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APA (6^th Edition):

Toy, R. (2014). The Effect of Particle Size and Shape on the In Vivo Journey of Nanoparticles. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1396887959

Chicago Manual of Style (16^th Edition):

Toy, Randall. “The Effect of Particle Size and Shape on the In Vivo Journey of Nanoparticles.” 2014. Doctoral Dissertation, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1396887959.

MLA Handbook (7^th Edition):

Toy, Randall. “The Effect of Particle Size and Shape on the In Vivo Journey of Nanoparticles.” 2014. Web. 10 Dec 2019.

Vancouver:

Toy R. The Effect of Particle Size and Shape on the In Vivo Journey of Nanoparticles. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2014. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1396887959.

Council of Science Editors:

Toy R. The Effect of Particle Size and Shape on the In Vivo Journey of Nanoparticles. [Doctoral Dissertation]. Case Western Reserve University; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1396887959

22. Zhang, Yu. SYNTHESIS OF FLUORINATED AND IODINATED CARBOXYETHYLPYRROLE RECEPTOR LIGANDS.

Degree: PhD, Chemistry, 2014, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1380551750

► Cancer, a major health issue in the United States, is the second leading cause of death after disease of heart. The formation of new blood… (more)

▼ Cancer, a major health issue in the United States, is the second leading cause of death after disease of heart. The formation of new blood vessels, known as angiogenesis, which new capillaries sprout from the existing vessels, is believed to promote the tumor growth. Due to the dependence of tumor progression on angiogenesis, it has been an interesting field in the search of antiangiogenesis agents which stop the progression of tumor formation and also different types of receptors accounting for angiogenesis by the ever-evolving positron emission tomography (PET) technology. Phospholipids oxidation in biological systems contributes to diverse pathological processes and is also believed to introduce age-related diseases. Oxidative cleavage of phospholipids containing docosahexaenoic acid (DHA) yields the reactive electrophilic species such as 4-hydroxy-7-oxohept-enoates (HOHA) which would later on covalently bond to e-amino group of protein lysine residue and turn into the 2-(¿-carboxyethyl)pyrrole (CEP) protein adducts. The CEP adducts is found to be associated with age-related macular degeneration (AMD) by triggering the angiogenesis in the retina. Recent study also revealed the novel molecular pattern between CEP adducts and Toll-like receptor 2 (TLR2) which leads to the angiogenesis response. And it provides an alternative therapeutic target especially in cases cancers resistant to the conventional anti-VEGF therapy. Therefore it is necessary to synthesize the gamma radioactive isotope labeled CEP adducts and apply them for the targeting of TLR2 with PET imaging technique. A convenient synthesis of putative fluorine-18-labeled-CEP was achieved with satisfied yields and the fluorination condition was optimized as well because limited half-life of fluorine-18 (109.7min) required the reaction to be accomplished in a short time-frame. Meanwhile in order to overcome the limited stability of CEP adducts which prevents its long-term usage as standards in immunosorbent assays, their electron-deficient isostere, carboxyethylpyrazoles were synthesized. These synthesized pyrazole compounds showed their similar biological affinity with anti-CEP antibody and were also found to be able to introduce angiogenesis of endothelial cells. Therefore, it provides another approach to the PET imaging of TLR2 expression by incorporating radioactive iodine species. Advisors/Committee Members: Lee, Irene (Committee Chair), Salomon, Robert (Advisor).

Subjects/Keywords: Biochemistry; Analytical Chemistry; Organic Chemistry; Cancer Angiogenesis Phospholipids DHA CEP TLR2 PET VEGF AMD fluorine iodine imaging pyrrole pyrazole

…method for separation of 3.5 88 x LIST OF FIGURES Chapter 1 Figure 1.1 Top ten cancer… …Iodinated Carboxyethylpyrrole Receptor Ligands Abstract By YU ZHANG Cancer, a major health issue… …adducts and apply them for the targeting of TLR2 with PET imaging technique. A convenient… …it provides another approach to the PET imaging of TLR2 expression by incorporating… …radioactive iodine species. xxii Chapter 1 Introduction 1 1.1 Cancer and its dependency on…

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APA (6^th Edition):

Zhang, Y. (2014). SYNTHESIS OF FLUORINATED AND IODINATED CARBOXYETHYLPYRROLE RECEPTOR LIGANDS. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1380551750

Chicago Manual of Style (16^th Edition):

Zhang, Yu. “SYNTHESIS OF FLUORINATED AND IODINATED CARBOXYETHYLPYRROLE RECEPTOR LIGANDS.” 2014. Doctoral Dissertation, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1380551750.

MLA Handbook (7^th Edition):

Zhang, Yu. “SYNTHESIS OF FLUORINATED AND IODINATED CARBOXYETHYLPYRROLE RECEPTOR LIGANDS.” 2014. Web. 10 Dec 2019.

Vancouver:

Zhang Y. SYNTHESIS OF FLUORINATED AND IODINATED CARBOXYETHYLPYRROLE RECEPTOR LIGANDS. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2014. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1380551750.

Council of Science Editors:

Zhang Y. SYNTHESIS OF FLUORINATED AND IODINATED CARBOXYETHYLPYRROLE RECEPTOR LIGANDS. [Doctoral Dissertation]. Case Western Reserve University; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1380551750

23. Antunes, Jacob T, Antunes. Quantitative Treatment Response Characterization In Vivo: UseCases in Renal and Rectal Cancers.

Degree: MSs (Engineering), Biomedical Engineering, 2016, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922

► Medical imaging has become widespread for evaluating treatment response invivo by measuring changes in tumor size or contrast uptake. However, the imagingdata alone is limited… (more)

Subjects/Keywords: Biomedical Engineering; Biomedical Research; Medical Imaging; Radiomics; treatment response; computerized analysis; PET-MRI; radiology; pathology; co-registration; rectal cancer

…treatment effects in rectal cancer onto the imaging. 1.3 Thesis Overview This thesis presents… …response on in vivo imaging in the context of renal cell carcinoma and rectal cancer. The… …vision and enthusiasm about developing state-of-the-art medical imaging analysis technology for… …of Computational Imaging and Personalized Diagnostics (CCIPD), thank you for the… …worked alongside some of the brightest–and youngest–minds in the medical imaging analysis field…

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APA (6^th Edition):

Antunes, Jacob T, A. (2016). Quantitative Treatment Response Characterization In Vivo: UseCases in Renal and Rectal Cancers. (Masters Thesis). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922

Chicago Manual of Style (16^th Edition):

Antunes, Jacob T, Antunes. “Quantitative Treatment Response Characterization In Vivo: UseCases in Renal and Rectal Cancers.” 2016. Masters Thesis, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922.

MLA Handbook (7^th Edition):

Antunes, Jacob T, Antunes. “Quantitative Treatment Response Characterization In Vivo: UseCases in Renal and Rectal Cancers.” 2016. Web. 10 Dec 2019.

Vancouver:

Antunes, Jacob T A. Quantitative Treatment Response Characterization In Vivo: UseCases in Renal and Rectal Cancers. [Internet] [Masters thesis]. Case Western Reserve University; 2016. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922.

Council of Science Editors:

Antunes, Jacob T A. Quantitative Treatment Response Characterization In Vivo: UseCases in Renal and Rectal Cancers. [Masters Thesis]. Case Western Reserve University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922

24. Singanamalli, Asha. Annotation, Enrichment and Fusion of Multiscale Data: Identifying High Risk Prostate Cancer.

Degree: MSs (Engineering), Biomedical Engineering, 2014, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1386084613

► Increasingly, advanced diagnostic techniques have begun to generate large volumes of multiscale, multimodal data spanning radiologic, histologic and molecular length scales. Although these data streams… (more)

Subjects/Keywords: Biomedical Engineering; imaging biomarkers; data fusion; data enrichment; prostate cancer

…cancer imaging. MRI techniques have significantly evolved both in terms of image resolution… …invasive, molecular imaging Ability to localize and indicate prostate cancer aggressiveness High… …Summary of imaging methods for prostate cancer cells. Apparent diffusion coefficient (ADC… …imaging biomarkers for high-risk prostate cancer. 4.1.3 Challenges in radiohistomorphometry… …angiogenic capacity [48]. 4.2.2 Role of radiological imaging in prostate cancer…

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APA (6^th Edition):

Singanamalli, A. (2014). Annotation, Enrichment and Fusion of Multiscale Data: Identifying High Risk Prostate Cancer. (Masters Thesis). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1386084613

Chicago Manual of Style (16^th Edition):

Singanamalli, Asha. “Annotation, Enrichment and Fusion of Multiscale Data: Identifying High Risk Prostate Cancer.” 2014. Masters Thesis, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1386084613.

MLA Handbook (7^th Edition):

Singanamalli, Asha. “Annotation, Enrichment and Fusion of Multiscale Data: Identifying High Risk Prostate Cancer.” 2014. Web. 10 Dec 2019.

Vancouver:

Singanamalli A. Annotation, Enrichment and Fusion of Multiscale Data: Identifying High Risk Prostate Cancer. [Internet] [Masters thesis]. Case Western Reserve University; 2014. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1386084613.

Council of Science Editors:

Singanamalli A. Annotation, Enrichment and Fusion of Multiscale Data: Identifying High Risk Prostate Cancer. [Masters Thesis]. Case Western Reserve University; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1386084613

Case Western Reserve University

25. Penzias, Gregory. Identifying the Histomorphometric Basis of Predictive Radiomic Markers for Characterization of Prostate Cancer.

Degree: MSs (Engineering), Biomedical Engineering, 2017, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1473415195867117

► Radiomics has shown promise for in vivo prediction of cancer risk, thus providing a potential avenue for reducing over-treatment and unnecessarily invasive biopsy-based diagnosis. Radiomics… (more)

▼ Radiomics has shown promise for in vivo prediction of cancer risk, thus providing a potential avenue for reducing over-treatment and unnecessarily invasive biopsy-based diagnosis. Radiomics could be particularly beneficial for stratifying patients into different risk groups in the context of prostate cancer (PCa), for which limitations of current in vivo risk assessment result in over-diagnosis and over-treatment. Despite its promise, successful translation of radiomics into the clinic may require a more comprehensive understanding of the underlying morphologic tissue characteristics they reflect. Few studies, however, have attempted to establish the biological or histomorphometric basis for the performance of radiomics. Accomplishing this requires fusing the information obtained from the imaging modalities of radiology and histopathology, since the gold standard definition of PCa comes from histopathologic analysis of whole-mount specimens. The first step in performing this radiology-pathology fusion in PCa entails achieving spatial correspondence between preoperative in vivo magnetic resonance imaging (MRI) and ex vivo hematoxylin & eosin (H&E)-stained whole-mount radical prostatectomy specimens via deformable co-registration. Co-registration, however, requires whole-mount histology sections (WMHSs), which are not always feasible to obtain. In such cases, large specimens are cut into multiple smaller tissue fragments. This thesis presents work on two related modules of radiology-pathology fusion in PCa: First, a novel automated program called AutoStitcher, which reconstructs pseudo whole-mount histology sections (PWMHSs) by digitally stitching together multiple smaller tissue fragments, thus enabling co-registration with in vivo radiographic imagery. AutoStitcher reconstructed PWMHSs with less than 3% error relative to manually stitched PWMHSs. Second, comprehensive sets of radiomic features extracted from MRI and quantitative histomorphometric features from H&E were extracted and then spatially co-localized to characterize each tumor region. Correlative analysis revealed a set of promising predictive radiomic markers that could accurately distinguish low- from intermediate-/high-risk PCa and a set of QH features that may form their histomorphometric basis. Results were validated on an independent dataset from a different institution. Advisors/Committee Members: Madabhushi, Anant (Advisor).

Subjects/Keywords: Biomedical Engineering; Computer Science; Medical Imaging; Radiology; Oncology; Engineering; radiomics; quantitative histomorphometry; prostate cancer; imaging biomarkers; digital pathology; data fusion; computer vision; image reconstruction; image stitching

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APA (6^th Edition):

Penzias, G. (2017). Identifying the Histomorphometric Basis of Predictive Radiomic Markers for Characterization of Prostate Cancer. (Masters Thesis). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1473415195867117

Chicago Manual of Style (16^th Edition):

Penzias, Gregory. “Identifying the Histomorphometric Basis of Predictive Radiomic Markers for Characterization of Prostate Cancer.” 2017. Masters Thesis, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1473415195867117.

MLA Handbook (7^th Edition):

Penzias, Gregory. “Identifying the Histomorphometric Basis of Predictive Radiomic Markers for Characterization of Prostate Cancer.” 2017. Web. 10 Dec 2019.

Vancouver:

Penzias G. Identifying the Histomorphometric Basis of Predictive Radiomic Markers for Characterization of Prostate Cancer. [Internet] [Masters thesis]. Case Western Reserve University; 2017. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1473415195867117.

Council of Science Editors:

Penzias G. Identifying the Histomorphometric Basis of Predictive Radiomic Markers for Characterization of Prostate Cancer. [Masters Thesis]. Case Western Reserve University; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1473415195867117

26. Hernandez, Christopher. Stabilized Nanobubbles for Diagnostic Applications.

Degree: PhD, Biomedical Engineering, 2018, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1521123706295258

► Bulk nanobubbles, also known as ultrafine bubbles (ISO/ TC281), have recently gained the interest of the research community for their potential application as ultrasound contrast… (more)

▼ Bulk nanobubbles, also known as ultrafine bubbles (ISO/ TC281), have recently gained the interest of the research community for their potential application as ultrasound contrast agents for molecular imaging and cancer therapy. However, even with this growing interest, the very existence of nanobubbles and their use as contrast agents have been a subject of controversy for over a decade. This is due to the theoretical effect of reducing the bubble diameter to the nanoscale on both its Laplace pressure and resonance frequency leading to instability and reduced imaging quality, respectively. Despite these theoretical limitations, we have developed a stable and echogenic nanobubble formulation through incorporation of Pluronic, a nonionic triblock co-polymer surfactant, into the lipid shell of perfluorocarbon gas bubbles. To further understand the biophysical properties of these novel nanobubbles, we explored factors contributing to their echogenicity, stability, and fate after gas dissipation. Bubbles were confirmed to be in the sub-micron range and produced strong contrast at clinical ultrasound frequencies. Additionally, it was demonstrated that the incorporation of Pluronic into the lipid membrane increases the stability of nanobubbles under ultrasound by decreasing its monolayer surface tension. Due to the strong interest in the use of nanobubbles as drug delivery agents, their ultimate fate when destroyed by high-power ultrasound was investigated using cryo-EM. Lastly, as a proof of study, CA-125 and PSMA-targeted nanobubbles were developed for the detection of ovarian and prostate cancer, respectively. Results demonstrated that nanobubbles can be used to target and reach antigens expressed on cancer cells beyond the tumor vasculature. Characterization and optimization of nanobubble properties achieved the creation of novel, stabilized nanobubbles for numerous potential clinical applications. Advisors/Committee Members: Exner, Agata (Advisor), von Recum, Horst (Committee Chair).

Subjects/Keywords: Biomedical Engineering; nanobubbles; microbubbles; ultrasound contrast agents; molecular imaging; cancer; diagnostic ultrasound; nanoparticles; surface tension; Langmuir-Blodgett; pendant drop; cryo-EM; Pluronic

…contrast agents for molecular imaging and cancer therapy. However, even with this growing… …Lipid-Coated Nanobubbles Sub-micron bubbles have recently gained interest in cancer imaging… …intensity ultrasound. Chapter 5: Ultrasound Molecular Imaging of Ovarian Cancer with CA-125… …the cancer is present. Modern medical imaging has been instrumental in aiding oncologists to… …characteristics of aggressive cancer? Even after cancer has been identified, imaging is not only used to…

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APA (6^th Edition):

Hernandez, C. (2018). Stabilized Nanobubbles for Diagnostic Applications. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1521123706295258

Chicago Manual of Style (16^th Edition):

Hernandez, Christopher. “Stabilized Nanobubbles for Diagnostic Applications.” 2018. Doctoral Dissertation, Case Western Reserve University. Accessed December 10, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1521123706295258.

MLA Handbook (7^th Edition):

Hernandez, Christopher. “Stabilized Nanobubbles for Diagnostic Applications.” 2018. Web. 10 Dec 2019.

Vancouver:

Hernandez C. Stabilized Nanobubbles for Diagnostic Applications. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2018. [cited 2019 Dec 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1521123706295258.

Council of Science Editors:

Hernandez C. Stabilized Nanobubbles for Diagnostic Applications. [Doctoral Dissertation]. Case Western Reserve University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1521123706295258

Central Queensland University

27. Pape, Ruth. Mammographic parenchymal patterns of New South Wales North Coast Aboriginal and Torres Strait Islander women.

Degree: 2014, Central Queensland University

URL: http://hdl.cqu.edu.au/10018/1031395

► The aim of this thesis was to document the distribution of mammographic parenchymal patterns (MPPs) for Australian Aboriginal and Torres Strait Islander women attending BreastScreen… (more)

Subjects/Keywords: Breast Imaging; Breast Radiography.; Mammography – Breast imaging – Breast parenchymal patterns – ATSI breast cancer risk – Breast density; Thesis; Book. e-thesis

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APA (6^th Edition):

Pape, R. (2014). Mammographic parenchymal patterns of New South Wales North Coast Aboriginal and Torres Strait Islander women. (Thesis). Central Queensland University. Retrieved from http://hdl.cqu.edu.au/10018/1031395

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pape, Ruth. “Mammographic parenchymal patterns of New South Wales North Coast Aboriginal and Torres Strait Islander women.” 2014. Thesis, Central Queensland University. Accessed December 10, 2019. http://hdl.cqu.edu.au/10018/1031395.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pape, Ruth. “Mammographic parenchymal patterns of New South Wales North Coast Aboriginal and Torres Strait Islander women.” 2014. Web. 10 Dec 2019.

Vancouver:

Pape R. Mammographic parenchymal patterns of New South Wales North Coast Aboriginal and Torres Strait Islander women. [Internet] [Thesis]. Central Queensland University; 2014. [cited 2019 Dec 10]. Available from: http://hdl.cqu.edu.au/10018/1031395.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pape R. Mammographic parenchymal patterns of New South Wales North Coast Aboriginal and Torres Strait Islander women. [Thesis]. Central Queensland University; 2014. Available from: http://hdl.cqu.edu.au/10018/1031395

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Central Queensland University

28. McLeod, Peter. Clustering based classifier for the classification of benign and malignant patterns in digital mammograms.

Degree: 2011, Central Queensland University

URL: http://hdl.cqu.edu.au/10018/916038

► "Breast cancer is a leading cause of cancerous deaths and the most frequently diagnosed form of cancer in women ... The process of interpreting mammograms… (more)

Subjects/Keywords: Breast; Mammography; Diagnostic imaging; Pure basic research.; 080108 Neural, Evolutionary and Fuzzy Computation.; 080106 Image Processing.; 080199 Artificial Intelligence and Image Processing not elsewhere classified.; 920102 Cancer and Related Disorders.; 920203 Diagnostic Methods.; Neural classifier – Diital mammography – Clustering – Breast cancer

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APA (6^th Edition):

McLeod, P. (2011). Clustering based classifier for the classification of benign and malignant patterns in digital mammograms. (Thesis). Central Queensland University. Retrieved from http://hdl.cqu.edu.au/10018/916038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McLeod, Peter. “Clustering based classifier for the classification of benign and malignant patterns in digital mammograms.” 2011. Thesis, Central Queensland University. Accessed December 10, 2019. http://hdl.cqu.edu.au/10018/916038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McLeod, Peter. “Clustering based classifier for the classification of benign and malignant patterns in digital mammograms.” 2011. Web. 10 Dec 2019.

Vancouver:

McLeod P. Clustering based classifier for the classification of benign and malignant patterns in digital mammograms. [Internet] [Thesis]. Central Queensland University; 2011. [cited 2019 Dec 10]. Available from: http://hdl.cqu.edu.au/10018/916038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McLeod P. Clustering based classifier for the classification of benign and malignant patterns in digital mammograms. [Thesis]. Central Queensland University; 2011. Available from: http://hdl.cqu.edu.au/10018/916038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Pescia, Daniel. Segmentation of liver tumors on CT images : Segmentation des tumeurs du foie sur des images de scanner CT.

Degree: Docteur es, Mathématiques appliquées aux systèmes, 2011, Châtenay-Malabry, Ecole centrale de Paris

URL: http://www.theses.fr/2011ECAP0002

►

Cette thèse porte sur la segmentation des tumeurs du foie sur des images tomodensitométriques. Ce sujet présente un intérêt certain pour le domaine médical puisque… (more)

▼

Cette thèse porte sur la segmentation des tumeurs du foie sur des images tomodensitométriques. Ce sujet présente un intérêt certain pour le domaine médical puisque les médecins pourraient ainsi bénéficier d’une méthode reproductible et fiable pour segmenter de telles lésions. Une segmentation précise des tumeurs du foie permettrait en effet d’aider les médecins lors de l’évaluation des lésions (détection, localisation, quantification), du choix d’un traitement, et de sa planification. Les méthodes développées dans ce cadre doivent faire face à trois principales difficultés scientifiques: (i) la grande variabilité de l’apparence et de la forme des structures recherchées, (ii) leur ressemblance avec les régions environnantes et finalement (iii) la faiblesse du rapport signal sur bruit observé dans les images dans lesquelles on travaille. Ce problème est abordé dans une optique d’application clinique et est résolu en suivant une approche en deux temps commençant par le calcul d’une enveloppe du foie, avant de segmenter les tumeurs présentes à l’intérieur de cette enveloppe. Nous commençons par proposer une approche basée sur des atlas pour le calcul d’une enveloppe des foies pathologiques. Tout d’abord, un outil de traitement d’image a été développé pour calculer une enveloppe autour d’un masque binaire, afin d’essayer d’obtenir une enveloppe du foie à partir d’une estimation du parenchyme sain. Un nouvel atlas statistique a ensuite été introduit, puis utilisé pour la segmentation à travers son recalage difféomorphique avec une image. La segmentation est finalement réalisée en combinant les coûts d’appariement des images avec des a priori spatiaux et d’apparence, le tout en suivant une approche multi échelle basée sur des MRFs. La deuxième étape de notre approche porte sur la segmentation des lésions contenues dans ces enveloppes en combinant des techniques d’apprentissage par ordinateur avec de méthodes basées sur des graphes. Un espace d’attributs approprié est tout d’abord défini en considérant des descripteurs de textures déterminés à travers des filtres de diverses tailles et orientations. Des méthodes avancées d’apprentissage automatique sont ensuite utilisées pour déterminer les attributs pertinents, ainsi que l’hyperplan qui sépare les voxels tumoraux des voxels correspondant à des tissus sains dans cet espace d’attributs. Pour finir, la segmentation est réalisée en minimisant une énergie sous forme de MRF, laquelle combine les probabilités d’appartenance de chaque voxel à une classe, avec celles de ses voisins. Des résultats prometteurs montrent les potentiels de notre méthode

This thesis is dedicated to 3D segmentation of liver tumors in CT images. This is a task of great clinical interest since it allows physicians benefiting from reproducible and reliable methods for segmenting such lesions. Accurate segmentation would indeed help them during the evaluation of the lesions, the choice of treatment and treatment planning. Such a complex segmentation task should cope with three main scientific challenges:…

Advisors/Committee Members: Paragios, Nikos (thesis director).

Subjects/Keywords: Foie; Cancer; Imagerie médicale; Liver; Cancer; Medical imaging

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APA (6^th Edition):

Pescia, D. (2011). Segmentation of liver tumors on CT images : Segmentation des tumeurs du foie sur des images de scanner CT. (Doctoral Dissertation). Châtenay-Malabry, Ecole centrale de Paris. Retrieved from http://www.theses.fr/2011ECAP0002

Chicago Manual of Style (16^th Edition):

Pescia, Daniel. “Segmentation of liver tumors on CT images : Segmentation des tumeurs du foie sur des images de scanner CT.” 2011. Doctoral Dissertation, Châtenay-Malabry, Ecole centrale de Paris. Accessed December 10, 2019. http://www.theses.fr/2011ECAP0002.

MLA Handbook (7^th Edition):

Pescia, Daniel. “Segmentation of liver tumors on CT images : Segmentation des tumeurs du foie sur des images de scanner CT.” 2011. Web. 10 Dec 2019.

Vancouver:

Pescia D. Segmentation of liver tumors on CT images : Segmentation des tumeurs du foie sur des images de scanner CT. [Internet] [Doctoral dissertation]. Châtenay-Malabry, Ecole centrale de Paris; 2011. [cited 2019 Dec 10]. Available from: http://www.theses.fr/2011ECAP0002.

Council of Science Editors:

Pescia D. Segmentation of liver tumors on CT images : Segmentation des tumeurs du foie sur des images de scanner CT. [Doctoral Dissertation]. Châtenay-Malabry, Ecole centrale de Paris; 2011. Available from: http://www.theses.fr/2011ECAP0002

Clemson University

30. Bland, Erik. QUANTITATIVE, SPATIAL IMAGING BASED MEASUREMENTS TO ASSESS CELLULAR HEALTH AND OXYGENATION IN A TISSUE ENGINEERED TEST SYSTEM.

Degree: PhD, Bioengineering, 2012, Clemson University

URL: https://tigerprints.clemson.edu/all_dissertations/929

► Three-dimensional in vitro tissue test systems are employed to examine cell behavior, test responses to drugs and vaccines, and answer basic biological questions. These systems… (more)

▼ Three-dimensional in vitro tissue test systems are employed to examine cell behavior, test responses to drugs and vaccines, and answer basic biological questions. These systems are more physiologically relevant than two-dimensional cell cultures, and are more relevant, easier and less expensive to maintain than animal models. However, methods used to measure cell behavior and viability have been developed specifically for two-dimensional cell cultures or animal models, and are often not optimally translated to three-dimensional in vitro test systems. The purpose of this work was to aid in the development of three-dimensional, spatially controlled in vitro test systems, and to develop the corresponding quantitative, spatial measurement methods of cell behavior and viability. Optical widefield microscopy was selected as a measurement tool because of its ease of use, wide availability, and inherent large-scale spatial measurement capacity. Digital image analysis and processing were used to collect quantitative data. Fluorescent cellular labels were examined for use in spatial, quantitative imaging, and methods were developed to quantify cell location, morphology, and viability from either fluorescent or phase contrast images. Maintenance of oxygen supply to cells is integral in a tissue engineered construct and in 3D in vitro test systems. Cells in the body are supplied oxygen by the vasculature, but in tissue engineered constructs, cells must be supported by oxygen diffusion alone. In addition to tracking cellular behavior, microscope digital image processing was used in conjunction with fluorescent oxygen-sensitive nanoparticles for the quantitative, spatial measurement of oxygen in a 3D in vitro test system. These methods were used to confirm the presence of oxygen gradients that occur in 3D cell cultures due to cellular oxygen consumption. Artifacts that impede quantitative fluorescence imaging were identified, and fluorescence ratio imaging was used to minimize artifacts and facilitate quantitative oxygen measurement. In follow-up work, methods were developed to allow sterile microscope imaging and culture of cells in a 3D tissue engineered construct; the setup allowed spatial control of oxygen delivery to approximate oxygenation via vasculature in the body. An oxygen-gradient bioreactor was developed and imaging techniques were used to show that culture medium perfusion rates can be used to control the rate of distribution of a factor or gas, such as oxygen, throughout a tissue engineered construct. Lastly, a 3D in vitro hydrogel test system with modular substrate stiffness was created and assessed using quantitative cellular imaging methods to examine cancer development. Cancer cell behavior has been shown to be strongly correlated to local stiffness variations in the extracellular matrix; however, this relationship is not well understood. Human breast cancer cells were cultured on hydrogel substrates of varying mechanical properties, and quantitative… Advisors/Committee Members: Burg, Karen J.L., Webb , Ken, Laberge , Martine, Bridges , Billy.

Subjects/Keywords: cancer; hypoxia; imaging; tissue engineering; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Bland, E. (2012). QUANTITATIVE, SPATIAL IMAGING BASED MEASUREMENTS TO ASSESS CELLULAR HEALTH AND OXYGENATION IN A TISSUE ENGINEERED TEST SYSTEM. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/929

Chicago Manual of Style (16^th Edition):

Bland, Erik. “QUANTITATIVE, SPATIAL IMAGING BASED MEASUREMENTS TO ASSESS CELLULAR HEALTH AND OXYGENATION IN A TISSUE ENGINEERED TEST SYSTEM.” 2012. Doctoral Dissertation, Clemson University. Accessed December 10, 2019. https://tigerprints.clemson.edu/all_dissertations/929.

MLA Handbook (7^th Edition):

Bland, Erik. “QUANTITATIVE, SPATIAL IMAGING BASED MEASUREMENTS TO ASSESS CELLULAR HEALTH AND OXYGENATION IN A TISSUE ENGINEERED TEST SYSTEM.” 2012. Web. 10 Dec 2019.

Vancouver:

Bland E. QUANTITATIVE, SPATIAL IMAGING BASED MEASUREMENTS TO ASSESS CELLULAR HEALTH AND OXYGENATION IN A TISSUE ENGINEERED TEST SYSTEM. [Internet] [Doctoral dissertation]. Clemson University; 2012. [cited 2019 Dec 10]. Available from: https://tigerprints.clemson.edu/all_dissertations/929.

Council of Science Editors:

Bland E. QUANTITATIVE, SPATIAL IMAGING BASED MEASUREMENTS TO ASSESS CELLULAR HEALTH AND OXYGENATION IN A TISSUE ENGINEERED TEST SYSTEM. [Doctoral Dissertation]. Clemson University; 2012. Available from: https://tigerprints.clemson.edu/all_dissertations/929

Open Access Theses and Dissertations