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University of Zambia
1.
Siamuyoba, Lawrence S.
Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital
.
Degree: 2012, University of Zambia
URL: http://hdl.handle.net/123456789/1391 
► To determine the incidence, common indications,appropriateness and outcome of blood transfusions and blood products among adult in-patients admitted to the University teaching Hospital, Lusaka, Zambia.…
(more)
▼ To determine the incidence, common indications,appropriateness and outcome of blood transfusions and blood products among adult in-patients admitted to the University
teaching Hospital, Lusaka, Zambia.
Prospective observational study over a period of 90 days.The university Teaching Hospital and the Zambia National Blood Transfusion Services.Indications for blood transfusion, number of units prescribed and given, the age and sex of the transfusion
recipients.All adult patients who received blood transfusion during the period of the study. Data collected by research
assistant.Of the 378 requests for blood transfusion we followed up 149 such patients. These received at total of 271 units of blood. 75[27.6%] of the units were given to medical patients, 87[32.17o] to surgical patients and 113[41.3%] to patients from the department of obstetrics and Gynaecology. Females got twice as much blood as males, 67.3% compared to the male with only 32.7%. Most of the blood transfusions were given to patients between the ages of 23 and 42, receiving a total of 74%
of the units of blood. 63% of these are less than 30 years of age. The most common indication for blood transfusion was
indicated only as anemia. Up to 98% of patient receiving blood transfusion did not have hemoglobin done prior to transfusion.
In the university teaching hospital of Lusaka,Zambia, more blood is used mainly in the department of obstetric and gynecology. It can also be concluded that demand for blood products is higher younger patients. It was observed that the use of blood and blood products is inappropriate in most
cases as blood was given based on the clinical presence of pallor as a measure of anaemia.it is recommended that blood prescribers acquaint themselves with existing guidelines to avoid
indiscriminate use of blood products. Careful evaluation of the risks and potential benefits of transfusion is required. All anemia, except in cases where it is life threatening, should be
investigated adequately. Blood transfusion is no substitute for finding the cause of anaemia.
Subjects/Keywords: Blood – Transfusion;
Blood – Products
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APA (6th Edition):
Siamuyoba, L. S. (2012). Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1391
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Siamuyoba, Lawrence S. “Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital
.” 2012. Thesis, University of Zambia. Accessed March 07, 2021.
http://hdl.handle.net/123456789/1391.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Siamuyoba, Lawrence S. “Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital
.” 2012. Web. 07 Mar 2021.
Vancouver:
Siamuyoba LS. Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital
. [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/123456789/1391.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Siamuyoba LS. Prospective observational study of blood transfusion practices and outcome at the University Teaching Hospital
. [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1391
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
2.
James, Vasanthie.
The perceptions of health-care professionals regarding blood conservation in the private health sector.
Degree: 2011, University of Johannesburg
URL: http://hdl.handle.net/10210/4194
► M.Cur.
Awareness of the growing list of potential and inherent risks and hazards associated with receiving donor blood has created a mushrooming interest in alternatives…
(more)
▼ M.Cur.
Awareness of the growing list of potential and inherent risks and hazards associated with receiving donor blood has created a mushrooming interest in alternatives to blood transfusion. Despite the fact that there are programmes, protocols and guidelines in place in the private health sector, blood conservation has not got off the ground. Therefore the aim of this study was to explore and describe the perceptions of health-care professionals regarding blood conservation in the private health sector. An exploratory descriptive contextual design was employed. Data was collected through the use of semi-structured focus group and individual interviews. Conceptualisation as well as data from the interviews served as the basis for the formulation of guidelines for health-care professionals to improve blood conservation. The results of this research show that the interaction among health-care professionals are negatively influenced by the lack of communication, feedback, support and uncertainty, a lack of trust, education, planning, implementation, involvement, commitment and co-ordination. Therefore the outcome of blood conservation cannot be achieved. Effective communication, education and participatory management have to improve in order for these negative factors to be overcome. It is recommended that these guidelines be implemented to improve blood conservation in the private health sector. Conclusions, limitations and further recommendations were made based on the results of this study.
Subjects/Keywords: Blood transfusion; Blood banks
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APA (6th Edition):
James, V. (2011). The perceptions of health-care professionals regarding blood conservation in the private health sector. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/4194
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
James, Vasanthie. “The perceptions of health-care professionals regarding blood conservation in the private health sector.” 2011. Thesis, University of Johannesburg. Accessed March 07, 2021.
http://hdl.handle.net/10210/4194.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
James, Vasanthie. “The perceptions of health-care professionals regarding blood conservation in the private health sector.” 2011. Web. 07 Mar 2021.
Vancouver:
James V. The perceptions of health-care professionals regarding blood conservation in the private health sector. [Internet] [Thesis]. University of Johannesburg; 2011. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10210/4194.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
James V. The perceptions of health-care professionals regarding blood conservation in the private health sector. [Thesis]. University of Johannesburg; 2011. Available from: http://hdl.handle.net/10210/4194
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Chicago
3.
Hsu, Chih-Yang.
Medical Imaging Techniques for Characterizing Cerebral Angioarchitecture.
Degree: 2017, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/21822
► There is a fundamental gap in how blood flow quantification can be accomplished in interventional digital subtraction angiography (DSA) to provide physicians with measurements to…
(more)
▼ There is a fundamental gap in how
blood flow quantification can be accomplished in interventional digital subtraction angiography (DSA) to provide physicians with measurements to interpret the patient’s vascular health. Continued existence of this gap represents an important problem because, until it is filled, physicians can only rely on qualitative information of intensity changes to understand
blood flow variations caused by the intervention treatment.
The long-term goal is to transform DSA, the gold standard for qualitative
blood flow assessment, into a fully automated quantitative measurement tool that can potentially aid clinical decision making in endovascular interventions. Current approaches focus on using signals from a single vessel to determine
blood flow and have not been successful due to the slow frame rate.
It is our central hypothesis that a radically different flow quantification approach, using all the information from the entire image set concurrently to overcome the slow DSA frame rate, will provide reliable
blood flow measurement in all vessels. The immediate objective is to create the proposed whole-tree DSA
blood flow measurement method and to test its feasibility and accuracy. Success here would justify a future clinical trial of DSA-based flow measurement.
The results of our study will be used to determine whether our global approach can provide reliable flow quantification in a clinical situation. The approach is innovative, because it uses global information to reliably measurement the
blood flow rate in DSA. The proposed research is significant, because it is expected to rapidly produce reliable flow measurements in all visible vessels to facilitate physician’s understanding of patient’s vascular status. The novel technique will gap the bridge between the large arteries and micro vessels, providing flow measurements in all visible vessels that can be used to study cerebral hemodynamics. Ultimately, such technique has the potential to alternate clinical decision making for better treatment prognosis to reduce healthcare cost in treating cerebral vascular diseases.
Advisors/Committee Members: Linninger, Andreas (advisor), Diwekar, Urmila (committee member), Zhou, Xiaohong (committee member), Magin, Richard (committee member), Alaraj, Ali (committee member), Linninger, Andreas (chair).
Subjects/Keywords: Blood vessels; blood flow
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Manager
APA (6th Edition):
Hsu, C. (2017). Medical Imaging Techniques for Characterizing Cerebral Angioarchitecture. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21822
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hsu, Chih-Yang. “Medical Imaging Techniques for Characterizing Cerebral Angioarchitecture.” 2017. Thesis, University of Illinois – Chicago. Accessed March 07, 2021.
http://hdl.handle.net/10027/21822.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hsu, Chih-Yang. “Medical Imaging Techniques for Characterizing Cerebral Angioarchitecture.” 2017. Web. 07 Mar 2021.
Vancouver:
Hsu C. Medical Imaging Techniques for Characterizing Cerebral Angioarchitecture. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10027/21822.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hsu C. Medical Imaging Techniques for Characterizing Cerebral Angioarchitecture. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/21822
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
4.
Mwale, Abel.
The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia
.
Degree: 2016, University of Zambia
URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4722
► In low-and middle-income countries (LMICs) the maintenance of standards relating to the transport and storage of blood may be more difficult to achieve. Bacteria contamination…
(more)
▼ In low-and middle-income countries (LMICs) the maintenance of standards relating
to the transport and storage of blood may be more difficult to achieve. Bacteria contamination and
hyperkalemia represent two significant risks. The objectives of this study were to assess the viability
of transfused blood defined by negative blood culture and potassium concentration of less than
42mmol/l.
Samples from 84 units of whole blood and packed cells were collected aseptically and
analyzed to determine the presence of bacteria by culturing and the level of potassium. Method of
storage/transport once the units left the blood bank (cool box or room temperature) was also recorded.
Results. 8 samples (10.5%) showed a positive culture and the organisms isolated included
Pseudomonas fluorescens, Corynabacterium, Acinetobacter baumannii and Staphylococcus capitis.
Only 12.5% of the culture positive units were stored in cooler boxes compared to 35.5% of the culture
negative units. The mean potassium content was 12.25mmol/l (±7.4SD). None of these were outside
the expected range for stored blood. However, blood stored at room temperature was found to have a
higher potassium concentration than blood stored in a cool box. The median time between blood
leaving the blood bank to the time the transfusion was actually commenced was 6(IQR±6) hours and
a range of 1-14hours.
Under the prevailing circumstances at the University Teaching Hospital, bacterial
contamination remains a significant risk in recipients of whole blood and packed cells. The current
practice, therefore, needs improvement. This study recommends continued medical education in the
transport and storage of blood and blood products.
Subjects/Keywords: Blood – Transfusion
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APA ·
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CSE |
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Manager
APA (6th Edition):
Mwale, A. (2016). The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia
. (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4722
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mwale, Abel. “The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia
.” 2016. Thesis, University of Zambia. Accessed March 07, 2021.
http://dspace.unza.zm:8080/xmlui/handle/123456789/4722.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mwale, Abel. “The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia
.” 2016. Web. 07 Mar 2021.
Vancouver:
Mwale A. The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia
. [Internet] [Thesis]. University of Zambia; 2016. [cited 2021 Mar 07].
Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4722.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mwale A. The Viability of Whole Blood and Packed Cells at the Time of Transfusion at the University Teaching Hospital in Lusaka Zambia
. [Thesis]. University of Zambia; 2016. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4722
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Appiah, Bernard.
Promoting Blood Donation in Sub-Saharan Africa: Role of Culture and Interventions.
Degree: 2013, Texas Digital Library
URL: http://hdl.handle.net/1969;
http://hdl.handle.net/2249.1/66866
► Inadequate blood donation is a major public health problem in Sub-Saharan Africa. This study examines the influence of culture and communication on blood donation in…
(more)
▼ Inadequate
blood donation is a major public health problem in Sub-Saharan Africa. This study examines the influence of culture and communication on
blood donation in Sub-Saharan Africa, with particular focus on Ghana.
The literature was systematically reviewed for aspects of culture and communication that influence
blood donation in Sub-Saharan Africa. Also, key informant interviews and focus group discussions with physicians, media professionals, and voluntary
blood donors in Ghana were used, both to identify barriers to
blood donation and to obtain some recommendations for designing interventions to boost
blood donation.
Literature searching yielded 3020 publications, including conference abstracts. Of them, 41 publications???representing 36 studies???met inclusion criteria and were critically appraised. Aspects of culture that were identified as influencing
blood donation in Sub-Saharan Africa included
blood donation-related misconceptions, religious beliefs, and influence of relatives. Communication channels that were identified for increasing
blood donation included mass media, mobile phones, and face-to-face contacts.
In Ghana, beliefs and attitudes of the public that were identified as barriers to
blood donations included misconceptions about
blood donation, such as the erroneous belief that hospital authorities were using donated
blood for rituals. Some respondents perceived that health professionals have not educated the public and journalists enough about
blood donation. Another perceived barrier to
blood donation was negative media reporting, such as indicating the percentage of
blood donors found to be HIV-positive. The lack of mutual trust between health professionals and journalists also served as a barrier to using the mass media to promote
blood donation.
To promote
blood donation, respondents in Ghana suggested several strategies, including broadcasting radio or television dramas about
blood donation in English and local languages to engage both literate and illiterate populations; providing media recognition of donors who achieve
blood donation-related milestones; having
blood donors serve as ambassadors of
blood donor drives; using social media to engage prospective younger
blood donors; and using mobile telephone caller tunes or ringback tones to publicize
blood donation.
Thus, many culture- and communication-related factors influence
blood donation in Sub-Saharan Africa. Those designing interventions to increase
blood donation in this region should consider these factors, including misconceptions, religious beliefs, family influences, and language.
Advisors/Committee Members: Burdine, James N (advisor).
Subjects/Keywords: blood donation
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APA ·
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Manager
APA (6th Edition):
Appiah, B. (2013). Promoting Blood Donation in Sub-Saharan Africa: Role of Culture and Interventions. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66866
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Appiah, Bernard. “Promoting Blood Donation in Sub-Saharan Africa: Role of Culture and Interventions.” 2013. Thesis, Texas Digital Library. Accessed March 07, 2021.
http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66866.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Appiah, Bernard. “Promoting Blood Donation in Sub-Saharan Africa: Role of Culture and Interventions.” 2013. Web. 07 Mar 2021.
Vancouver:
Appiah B. Promoting Blood Donation in Sub-Saharan Africa: Role of Culture and Interventions. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66866.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Appiah B. Promoting Blood Donation in Sub-Saharan Africa: Role of Culture and Interventions. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66866
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Wake Forest University
6.
Daniel, George.
VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND COGNITIVE FUNCTIONING IN LATE LIFE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS.
Degree: 2020, Wake Forest University
URL: http://hdl.handle.net/10339/96813
► Introduction: Alzheimer’s Disease and Related Dementias (ADRD) are a growing concern among the world’s increasingly large geriatric population. While no treatment exists to cure these…
(more)
▼ Introduction: Alzheimer’s Disease and Related Dementias (ADRD) are a growing concern among the world’s increasingly large geriatric population. While no treatment exists to cure these diseases, substantial evidence has pointed to the potential for cardio-metabolic risk factors, like Blood Pressure Variability (BPV) to reduce the prevalence and slow the progression of ADRDs. It has been shown that high BPV may be associated with poor neurobiological and cognitive outcomes, but less is known about this relationship in a healthy, multi-ethnic populations and the specific cognitive domains which are most impacted.
Subjects/Keywords: Blood Pressure
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APA ·
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APA (6th Edition):
Daniel, G. (2020). VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND COGNITIVE FUNCTIONING IN LATE LIFE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/96813
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Daniel, George. “VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND COGNITIVE FUNCTIONING IN LATE LIFE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS.” 2020. Thesis, Wake Forest University. Accessed March 07, 2021.
http://hdl.handle.net/10339/96813.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Daniel, George. “VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND COGNITIVE FUNCTIONING IN LATE LIFE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS.” 2020. Web. 07 Mar 2021.
Vancouver:
Daniel G. VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND COGNITIVE FUNCTIONING IN LATE LIFE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS. [Internet] [Thesis]. Wake Forest University; 2020. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10339/96813.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Daniel G. VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY AND COGNITIVE FUNCTIONING IN LATE LIFE: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS. [Thesis]. Wake Forest University; 2020. Available from: http://hdl.handle.net/10339/96813
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Central Connecticut State University
7.
Russ, Aaron E. (Aaron Earl), 1988-.
Effects of Calcium Lactate and Magnesium Lactate Supplementation on VO2peak and the Onset of Blood Lactate Accumulation.
Degree: Department of Physical Education and Human Performance, 2016, Central Connecticut State University
URL: http://content.library.ccsu.edu/u?/ccsutheses,2333
► Ergogenic aids are any substance that can improve performance. The use of nutritional ergogenic aids is widespread. Lactate supplementation is a form of potential ergogenic…
(more)
▼ Ergogenic aids are any substance that can improve performance. The use of nutritional ergogenic aids is widespread. Lactate supplementation is a form of potential ergogenic aid that might improve acid based balance during exercise to improve physical performance. This study was designed to determine the effects that calcium, magnesium lactate supplementation has on aerobic performance quantified in VO2peak, and acid based regulation quantified using onset blood lactate accumulation (OBLA). Participants in this study were male and females (n=18) aged 18-37 recruited from a universities campus. Participants were randomly assigned to either a supplement group or a placebo group. The participants acted as their own control. Two days of testing were conducted: a pretest and a treatment test. A modified Bruce protocol graded exercise test was conducted on a cycle ergometer. The supplement containing calcium and magnesium lactate was compared to a placebo, pre to post changes to evaluate performance changes. During exercise blood lactate values, oxygen consumption, rating of perceived exertion and heart rate were measured during the last thirty seconds of each stage. Oxygen consumption was measured using a standard VO2peak test using a metabolic cart. OBLA was determined from blood lactate samples analyzed using a blood lactate analyzer during exercise testing. VO2peak, OBlA power, time to exhaustion, heart rate at OBLA, percent heart rate max at OBLA, OBLA at VO2, percent VO2 at OBLA and RPE at OBLA where all compared pre to post to determine changes. Data analysis was conducted using a mixed repeated measures analysis of variance (ANOVA) in SPSS software. No statistical significant differences were observed pre to post lactate supplementation. The placebo did improve VO2peak post treatment (p=0.013), all other comparisons were non-significant. The findings of the current study show that lactate supplementation does not improve direct performance indicators quantified in VO2peak and OBLA. This study’s findings are consistent with previous research conducted. In conclusion, athletes should explore the use of other proven methods/ergogenic aids to extend the limits of sports performance.
"Submitted in Partial Fulfillment of the Requirements of the Degree of Masters of Science in Exercise Science."; Thesis advisor: Chee Hoi Leong.; M.S.,Central Connecticut State University,,2016.;
Advisors/Committee Members: Leong, Chee Hoi.
Subjects/Keywords: Blood lactate.
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APA (6th Edition):
Russ, Aaron E. (Aaron Earl), 1. (2016). Effects of Calcium Lactate and Magnesium Lactate Supplementation on VO2peak and the Onset of Blood Lactate Accumulation. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,2333
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Russ, Aaron E. (Aaron Earl), 1988-. “Effects of Calcium Lactate and Magnesium Lactate Supplementation on VO2peak and the Onset of Blood Lactate Accumulation.” 2016. Thesis, Central Connecticut State University. Accessed March 07, 2021.
http://content.library.ccsu.edu/u?/ccsutheses,2333.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Russ, Aaron E. (Aaron Earl), 1988-. “Effects of Calcium Lactate and Magnesium Lactate Supplementation on VO2peak and the Onset of Blood Lactate Accumulation.” 2016. Web. 07 Mar 2021.
Vancouver:
Russ, Aaron E. (Aaron Earl) 1. Effects of Calcium Lactate and Magnesium Lactate Supplementation on VO2peak and the Onset of Blood Lactate Accumulation. [Internet] [Thesis]. Central Connecticut State University; 2016. [cited 2021 Mar 07].
Available from: http://content.library.ccsu.edu/u?/ccsutheses,2333.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Russ, Aaron E. (Aaron Earl) 1. Effects of Calcium Lactate and Magnesium Lactate Supplementation on VO2peak and the Onset of Blood Lactate Accumulation. [Thesis]. Central Connecticut State University; 2016. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2333
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Rochester
8.
Bell, Robert D.
Cerebral Vascular Dysfunction in Alzheimer’s
Disease.
Degree: PhD, 2011, University of Rochester
URL: http://hdl.handle.net/1802/14591
► The neurovascular unit is comprised of brain endothelium, pericytes, vascular smooth muscle cells (VSMC), astrocytes, microglia and neurons. Complex and dynamic communication between the cells…
(more)
▼ The neurovascular unit is comprised of brain
endothelium, pericytes, vascular smooth muscle cells (VSMC),
astrocytes, microglia and neurons. Complex and dynamic
communication between the cells of the neurovascular unit is
essential for maintaining normal brain function. Recently, the role
of cerebral vascular dysfunction has been highlighted in several
neurodegenerative disease processes, such as Alzheimer’s disease
(AD). Here, I utilized multiple experimental models to test the
central hypothesis that cerebral vascular dysfunction can
contribute to AD pathogenesis. We found that (1) cerebral vascular
dysfunction, mediated by pericyte deficiency in adult mice, can
lead to neurodegeneration, (2) molecular changes specifically
within brain VSMC can contribute to the development of AD-like
pathologies in the cerebral cortex and (3) a known inherited
genetic risk factor for AD may contribute to the cerebral vascular
damage that is present during disease pathogenesis.
First,
pericytes play a key role in the development of the cerebral
microcirculation, although the exact role of pericytes in the adult
brain remains elusive. Using adult viable mice with varying degrees
of pericyte deficiency, we show that pericyte loss leads to
reduction in brain microcirculation causing chronic perfusion
stress and hypoxia, and blood-brain barrier breakdown associated
with brain accumulation of vasculotoxic and/or neurotoxic serum
proteins. Age-dependent vascular damage in pericyte-deficient mice
precedes neuronal degenerative changes, and learning and memory
impairment. Thus, pericytes control key neurovascular functions
that are necessary for proper neuronal structure and function, and
pericyte loss results in progressive age-dependent
vascular-mediated neurodegeneration. This study provides
proof-of-principle evidence supporting the hypothesis that vascular
damage may initiate neurodegenerative disease processes.
Next,
we investigate the molecular basis of a vascular-specific insult
mediated by amyloid -peptide (A) deposition in cerebral vessels,
called cerebral amyloid angiopathy, which contributes to AD
pathogenesis. Here, we report increased levels of two proteins,
serum response factor (SRF) and myocardin (MYOCD), in cerebral VSMC
in AD and in two mouse models of AD generates an A non-clearing
VSMC phenotype via transactivation of sterol regulatory element
binding protein-2, which downregulates low density lipoprotein
receptor-related protein-1, a key A clearance receptor. Hypoxia
stimulated SRF/MYOCD expression in human cerebral VSMC and in an AD
mouse model. We suggest SRF and MYOCD constitute a new
transcriptional switch controlling cerebrovascular clearance and
progression of AD. This study supports the hypothesis that
molecular changes specifically in vascular cells of the
neurovascular unit may contribute to AD pathogenesis.
Finally,
the apolipoprotein E4 (APOE4) allele is an inherited genetic risk
factor for the development of neurological disorders that are
associated with neurovascular dysfunction,…
Subjects/Keywords: Neurovascular; Blood Brain Barrier; Cerebral Blood Flow
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APA (6th Edition):
Bell, R. D. (2011). Cerebral Vascular Dysfunction in Alzheimer’s
Disease. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/14591
Chicago Manual of Style (16th Edition):
Bell, Robert D. “Cerebral Vascular Dysfunction in Alzheimer’s
Disease.” 2011. Doctoral Dissertation, University of Rochester. Accessed March 07, 2021.
http://hdl.handle.net/1802/14591.
MLA Handbook (7th Edition):
Bell, Robert D. “Cerebral Vascular Dysfunction in Alzheimer’s
Disease.” 2011. Web. 07 Mar 2021.
Vancouver:
Bell RD. Cerebral Vascular Dysfunction in Alzheimer’s
Disease. [Internet] [Doctoral dissertation]. University of Rochester; 2011. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1802/14591.
Council of Science Editors:
Bell RD. Cerebral Vascular Dysfunction in Alzheimer’s
Disease. [Doctoral Dissertation]. University of Rochester; 2011. Available from: http://hdl.handle.net/1802/14591
Vanderbilt University
9.
Talati, Pratik.
Imaging Hippocampal Hemodynamics in Schizophrenia.
Degree: PhD, Neuroscience, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/13896
► The hippocampus is a medial temporal lobe structure involved in learning and memory. Several magnetic resonance imaging methods exist to investigate hippocampal structure and function…
(more)
▼ The hippocampus is a medial temporal lobe structure involved in learning and memory. Several magnetic resonance imaging methods exist to investigate hippocampal structure and function in vivo. Some of these methods provide information about the anterior and posterior hippocampus while other methods can examine its subfields. In this study, we applied several imaging techniques to study hippocampal structure,
blood volume (CBV), and
blood flow (CBF) in early psychosis and chronic schizophrenia. We characterized CBV gradients in the hippocampus and its subfields and found increased anterior CA1 CBV in chronic schizophrenia. Hippocampal CBF was normal in the same cohort of chronic, medicated patients. When we studied patients in early psychosis, we found no hippocampal volume and CBF differences. However, we found an inverse relationship between hippocampal volume and CBF and a trend towards increased anterior hippocampal CBV. This study provides comprehensive, multi-modal imaging to characterize hippocampal structural and functional alternations in a clinical population.
Advisors/Committee Members: Stephan H.W. Heckers, MD, MSc (committee member), Manus J Donahue, PhD (committee member), Brandon A. Ally, PhD (committee member), Bruce D. Carter, PhD (Committee Chair).
Subjects/Keywords: Neuroimaging; Hippocampus; Schizophrenia; Blood Volume; Blood Flow
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APA (6th Edition):
Talati, P. (2015). Imaging Hippocampal Hemodynamics in Schizophrenia. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13896
Chicago Manual of Style (16th Edition):
Talati, Pratik. “Imaging Hippocampal Hemodynamics in Schizophrenia.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed March 07, 2021.
http://hdl.handle.net/1803/13896.
MLA Handbook (7th Edition):
Talati, Pratik. “Imaging Hippocampal Hemodynamics in Schizophrenia.” 2015. Web. 07 Mar 2021.
Vancouver:
Talati P. Imaging Hippocampal Hemodynamics in Schizophrenia. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1803/13896.
Council of Science Editors:
Talati P. Imaging Hippocampal Hemodynamics in Schizophrenia. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/13896
University of California – San Diego
10.
Magill, Joyce Manon.
Hemostatic Effects of Novel Blood Replacement Products.
Degree: Bioengineering, 2019, University of California – San Diego
URL: http://www.escholarship.org/uc/item/5pg3z1md
► Blood transfusions are life-saving procedures designed to provide hemorrhaging patients with the ability to transport oxygen throughout their body by administering blood products. However, resources…
(more)
▼ Blood transfusions are life-saving procedures designed to provide hemorrhaging patients with the ability to transport oxygen throughout their body by administering blood products. However, resources for these procedures, namely blood donations, are steadily declining in the United States, raising concerns around blood availability during times of emergency or natural disaster. To prevent potential blood shortages, a variety of blood products, including red cell substitutes and plasma expanders, have been developed. Prior to clinical use of these products, their influence in the function of blood must be studied. One important consideration is their impact on the hemostatic state of a patient including prevalence of clotting and coagulation mechanisms impacted. The purpose of this work is to evaluate coagulation changes of four blood replacement products using existing tests and a newly proposed method. Rats were subjected to exchange-infusion of 20% of their blood volume, and a standard panel of clinical assays was performed to determine the impact of 5% HSA, Hextend®, PolyHSA, and PolyHb on coagulation. Results indicate that polymerized bovine hemoglobin supports hemostasis when exposed to collagen, suggesting promising applications for hemorrhaging trauma patients with extreme quantities of exposed collagen. A secondary study tested a different coagulation measurement technique that mimics blood flow in the microvasculature called a U-Thromboelastometer (UTEM), based on the concept of a U-manometer. Results of this study provide proof of concept of this method as it detected variance between red cell substitutes and plasma expanders in the mechanical properties of clots under physiological shear conditions.
Subjects/Keywords: Bioengineering; blood; blood replacement products; thromboelastogram
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APA (6th Edition):
Magill, J. M. (2019). Hemostatic Effects of Novel Blood Replacement Products. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/5pg3z1md
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Magill, Joyce Manon. “Hemostatic Effects of Novel Blood Replacement Products.” 2019. Thesis, University of California – San Diego. Accessed March 07, 2021.
http://www.escholarship.org/uc/item/5pg3z1md.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Magill, Joyce Manon. “Hemostatic Effects of Novel Blood Replacement Products.” 2019. Web. 07 Mar 2021.
Vancouver:
Magill JM. Hemostatic Effects of Novel Blood Replacement Products. [Internet] [Thesis]. University of California – San Diego; 2019. [cited 2021 Mar 07].
Available from: http://www.escholarship.org/uc/item/5pg3z1md.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Magill JM. Hemostatic Effects of Novel Blood Replacement Products. [Thesis]. University of California – San Diego; 2019. Available from: http://www.escholarship.org/uc/item/5pg3z1md
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Boston University
11.
Spencer, Bryan Ross.
Iron deficiency in blood donors: causes, symptoms, and mitigation strategies.
Degree: PhD, Epidemiology, 2017, Boston University
URL: http://hdl.handle.net/2144/25919
► Transfusion of blood products is a common medical procedure, and maintaining adequate blood supply depends on the unpaid donation of a small share of the…
(more)
▼ Transfusion of blood products is a common medical procedure, and maintaining adequate blood supply depends on the unpaid donation of a small share of the general population. The absence of pre-donation testing for iron status allows many donors with iron deficiency to donate blood. This dissertation seeks to enhance our understanding of the causes of iron deficiency among blood donors, the resultant symptoms, and the likely effectiveness of alternate strategies for reducing the risk of iron deficiency.
In Study 1, we used data from the REDS-II RISE prospective cohort study, over a 2-year follow-up period, to evaluate whether higher levels of dietary iron protect against incident iron deficiency in blood donors. Responses to a brief checklist of consumption of animal proteins were combined into an Iron Composite Score weighted for iron content and reported frequency. We found that donors reporting the lowest levels of iron consumption were more likely to develop advanced iron depletion during follow-up.
In Study 2, we performed an analysis of observational data from the STRIDE study, a randomized trial, to evaluate whether improvements in iron status were associated with improvements in reported fatigue levels. Using linear regression, we found that many donors had sizable changes in both reported levels of fatigue and in measures of iron status, but neither iron status nor changes in iron status was associated with fatigue at the end of 20–24 months follow-up.
In Study 3, we conducted a simulation study to evaluate the range of outcomes of different strategies that might be adopted by blood centers to reduce the prevalence of iron depletion in blood donors. Using inputs primarily from the REDS-II program, we simulated approaches that extended the minimum interval between donations, that promoted use of iron supplementation by blood donors, and that performed ferritin testing to determine donor iron stores and extended the donation interval to those with iron depletion. Only extending the current 8-week interval to 26 weeks approached a reduction by half of the proportion of blood donors who were iron deficient, but the estimated impact on blood supply was a 21% drop in blood availability. Those interventions impacting supply less were also less effective in reducing iron depletion.
Subjects/Keywords: Epidemiology; Blood transfusions; Iron deficiency; Blood donors
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APA ·
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Manager
APA (6th Edition):
Spencer, B. R. (2017). Iron deficiency in blood donors: causes, symptoms, and mitigation strategies. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/25919
Chicago Manual of Style (16th Edition):
Spencer, Bryan Ross. “Iron deficiency in blood donors: causes, symptoms, and mitigation strategies.” 2017. Doctoral Dissertation, Boston University. Accessed March 07, 2021.
http://hdl.handle.net/2144/25919.
MLA Handbook (7th Edition):
Spencer, Bryan Ross. “Iron deficiency in blood donors: causes, symptoms, and mitigation strategies.” 2017. Web. 07 Mar 2021.
Vancouver:
Spencer BR. Iron deficiency in blood donors: causes, symptoms, and mitigation strategies. [Internet] [Doctoral dissertation]. Boston University; 2017. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2144/25919.
Council of Science Editors:
Spencer BR. Iron deficiency in blood donors: causes, symptoms, and mitigation strategies. [Doctoral Dissertation]. Boston University; 2017. Available from: http://hdl.handle.net/2144/25919
Boston University
12.
Bagwe, Ketki Ravindra.
Evaluation of recently developed methods for the forensic detection of menstrual blood.
Degree: MS, Biomedical Forensic Sciences, 2018, Boston University
URL: http://hdl.handle.net/2144/30905
► Body fluid identification is an important aspect of forensic work, as it can help identify a suspect and provide information about the kind of criminal…
(more)
▼ Body fluid identification is an important aspect of forensic work, as it can help identify a suspect and provide information about the kind of criminal activity that took place.
Blood is one of the most commonly found body fluids at a crime scene. While visually it is easily distinguishable from other fluids, an accurate method is needed to differentiate between peripheral
blood and menstrual
blood. This differentiation could provide critical evidence regarding consent in an alleged sexual assault. The presence of peripheral
blood indicates a traumatic cause, whereas menstrual
blood points towards a natural bleeding cause. Accurate detection of menstrual
blood can also help with the reconstruction or corroboration of events.
Menstruation is the shedding of the internal lining of the uterus that occurs on a monthly basis in women of a reproductive age group. Menstrual
blood is different in composition from the peripheral
blood flowing through arteries and veins. It consists of a mixture of vaginal and cervical secretions, epithelial cells, debris from the endometrial lining,
blood and fibrinolytic products. The fibrinolytic products are associated with the prevention of
blood clot formation. Several methods have been researched and used for the detection of menstrual
blood. These include microscopy, identification of the lactate dehydrogenase isoenzyme, detection of fibrinolytic products, and profiling of messenger ribonucleic acid (mRNA) and micro RNA (miRNA). Even though menstrual
blood is encountered at crime scenes, a reliable routine procedure for its identification has not yet been incorporated in forensic laboratories.
In this study, four methods of detection of menstrual
blood were evaluated and compared with each other regarding efficacy. These methods are the LGC ParaDNA® Body Fluid ID Test, SERATEC® PMB Test, DIMERTEST® Latex Assay and Microscopic methods using Lugol’s Iodine and Dane’s staining method. The LGC ParaDNA® Body Fluid ID Test identifies menstrual
blood by detecting the mRNA marker MMP10. The SERATEC® PMB Test and DIMERTEST® Latex Assay both detect D-dimers present in menstrual
blood. In addition, the SERATEC® PMB Test can detect the presence of peripheral
blood. Microscopic identification is performed by identifying vaginal epithelial cells present in the menstrual
blood. Menstrual
blood samples were self-collected from six anonymous donors on three consecutive days of menses on either a cotton swatch or a cotton swab. Samples from the earliest day were tested in triplicate using the first three methods. For the fourth method, Lugol’s Iodine and Dane’s stain were applied to various cell types to test the utility of the stains.
The ParaDNA® Body Fluid ID Test, SERATEC® PMB test and the DIMERTEST® Latex Assay all show promise for the detection of menstrual
blood in forensic samples. None of the tests showed a cross reactivity to the other body fluids tested, but some ParaDNA® and DIMERTEST® samples yielded a false negative result for menstrual
blood or peripheral
blood. The SERATEC® PMB…
Advisors/Committee Members: Brodeur, Amy N. (advisor).
Subjects/Keywords: Biology; Blood; Forensic detection; Menstrual blood
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APA ·
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Export
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Manager
APA (6th Edition):
Bagwe, K. R. (2018). Evaluation of recently developed methods for the forensic detection of menstrual blood. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/30905
Chicago Manual of Style (16th Edition):
Bagwe, Ketki Ravindra. “Evaluation of recently developed methods for the forensic detection of menstrual blood.” 2018. Masters Thesis, Boston University. Accessed March 07, 2021.
http://hdl.handle.net/2144/30905.
MLA Handbook (7th Edition):
Bagwe, Ketki Ravindra. “Evaluation of recently developed methods for the forensic detection of menstrual blood.” 2018. Web. 07 Mar 2021.
Vancouver:
Bagwe KR. Evaluation of recently developed methods for the forensic detection of menstrual blood. [Internet] [Masters thesis]. Boston University; 2018. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2144/30905.
Council of Science Editors:
Bagwe KR. Evaluation of recently developed methods for the forensic detection of menstrual blood. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/30905
Hong Kong University of Science and Technology
13.
Lam, Alexander Ka Ngai.
Characterization of pressure reduction mechanism in treatment of intracranial aneurysm.
Degree: 2014, Hong Kong University of Science and Technology
URL: http://repository.ust.hk/ir/Record/1783.1-62779
;
https://doi.org/10.14711/thesis-b1274352
;
http://repository.ust.hk/ir/bitstream/1783.1-62779/1/th_redirect.html
► Intracranial aneurysm can be treated endoluminally without major surgery by placing embolization coils into the aneurysm or flow diverters across the aneurysm's neck. With these…
(more)
▼ Intracranial aneurysm can be treated endoluminally without major surgery by placing embolization coils into the aneurysm or flow diverters across the aneurysm's neck. With these placements, blood flow into the aneurysm is immediately reduced and the aneurysm is occluded in long term. However, clinical studies showed that recurrence risk of aneurysm treated by coils is high and aneurysm is known to rupture after deployment of flow diverters. The rupture risk due to tensional wall stress can be reduced if aneurysmal pressure is reduced with device deployment. In this study, four kinds of mechanisms were hypothesized to affect pressure: flow diverting effect and coagulation effect by flow diverter, and intra-aneurysmal flow reduction effect and coagulation effect with coils. Pressures inside rubber-model aneurysms were characterized with flowing anti-coagulated blood. The analysis showed that the pressure inside aneurysm was only marginally affected when flow diverters were deployed across the aneurysm necks. When blood coagulation capability was restored in the same setup, >10% pressure reductions were induced in 60 minutes or less. The results showed that coagulation in aneurysm is essential for reduction of aneurysmal pressure and rupture risk. Further experiments with packed coils in model aneurysm confirmed that coagulation in aneurysm is essential for aneurysmal pressure reduction. These characterization studies have led to better understanding on pressure behavior within aneurysm after deployment of different treatment device. In clinical practice and treatments, anti-coagulants such as heparin are routinely administered into patient's bloodstream as a means to prevent arterial stenosis. Aneurysmal pressure reduction cannot be effected unless coagulation can be selectively restored in the aneurysm without significantly affecting the heparin's anti-coagulating action in the parent vessel. To meet this need, novel coils coated with a bio-soluble polymer matrix have been developed. Local coagulation is restored inside aneurysm by loading the coating matrix with reversal drugs for anti-coagulants. The effect of the biosoluble drug-loaded coils on the pressure profile was experimentally studied using the aneurysm model with flowing heparinized human blood. Platinum coils were used as control for comparison. The results showed that aneurysmal pressure was reduced by >10% within an hour while only minor reduction was observed in the platinum coil case. These results confirmed that the coagulation-inducing coils can effectively reduce local aneurysmal pressure better than platinum coils. This suggests that risk of re-rupture can be better managed with the new drug-loaded coils when used in combination with flow diverters and stents in the acute treatment of ruptured intracranial aneurysms. This new coil device should address the anti-platelet medication problem as well and be adapted in-vivo for testing in the future.
Subjects/Keywords: Intracranial aneurysms
; Treatment
; Blood flow
; Blood pressure
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APA (6th Edition):
Lam, A. K. N. (2014). Characterization of pressure reduction mechanism in treatment of intracranial aneurysm. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-62779 ; https://doi.org/10.14711/thesis-b1274352 ; http://repository.ust.hk/ir/bitstream/1783.1-62779/1/th_redirect.html
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lam, Alexander Ka Ngai. “Characterization of pressure reduction mechanism in treatment of intracranial aneurysm.” 2014. Thesis, Hong Kong University of Science and Technology. Accessed March 07, 2021.
http://repository.ust.hk/ir/Record/1783.1-62779 ; https://doi.org/10.14711/thesis-b1274352 ; http://repository.ust.hk/ir/bitstream/1783.1-62779/1/th_redirect.html.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lam, Alexander Ka Ngai. “Characterization of pressure reduction mechanism in treatment of intracranial aneurysm.” 2014. Web. 07 Mar 2021.
Vancouver:
Lam AKN. Characterization of pressure reduction mechanism in treatment of intracranial aneurysm. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2014. [cited 2021 Mar 07].
Available from: http://repository.ust.hk/ir/Record/1783.1-62779 ; https://doi.org/10.14711/thesis-b1274352 ; http://repository.ust.hk/ir/bitstream/1783.1-62779/1/th_redirect.html.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lam AKN. Characterization of pressure reduction mechanism in treatment of intracranial aneurysm. [Thesis]. Hong Kong University of Science and Technology; 2014. Available from: http://repository.ust.hk/ir/Record/1783.1-62779 ; https://doi.org/10.14711/thesis-b1274352 ; http://repository.ust.hk/ir/bitstream/1783.1-62779/1/th_redirect.html
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Tasmania
14.
List, SS.
Methods to detect bacterial contamination of blood products.
Degree: 2005, University of Tasmania
URL: https://eprints.utas.edu.au/20600/1/whole_ListSarah2005_thesis.pdf
► Bacterial contamination of blood products presents an ongoing challenge to transfusion therapy. Contaminating bacteria are typically introduced in low numbers at the time of collection,…
(more)
▼ Bacterial contamination of blood products presents an ongoing challenge to transfusion therapy. Contaminating bacteria are typically introduced in low numbers at the time of collection, but can proliferate during storage to reach >10⁹ colony forming units/mL (CFUhnL). The consequences of contamination include product wastage and transfusion-transmitted sepsis, but in Australia screening is conducted on only 1% of products by a slow and labour-intensive culture method. Accordingly, there is a need for a more practicable and rapid assay. The purposes of this study were to investigate the growth kinetics of bacteria in stored products, and to develop a rapid method to detect them.
Pseudomonas, Staphylococcus and Yersinia species were inoculated into buffy coat platelet concentrates (PCs) and red cell concentrates (RCCs) at 10, 10² or 10³ CFU/mL and then stored at 22 ± 2°C, agitated for PCs, or at 4 ± 2°C, stationary for RCCs. Bacterial growth was monitored by plate count, and product spoilage (clumping or haemolysis) was noted. Even at the lowest inoculum, all bacterial species grew rapidly in PCs, although clumping was not observed until 3 to 5 days (>10⁷CFU/mL). In RCCs, all species were recovered after 36 days, but only P. fluorescens and Y. enterocolitica proliferated, reaching >10⁷ CFU/mL before causing haemolysis.
To detect bacterial contamination, we developed a PCR-based assay. A method using bead-beating and spin column purification extracted bacterial DNA from the densely cellular blood products in under 30 minutes. Using this template and primers targeting conserved regions of the bacterial 16S rRNA gene, a 1361-bp fragment was amplified from >30 bacterial species and strains tested at less than 10³ CFU/mL in all sample types. Examination of the PCR product using Southern blotting with specific oligonucleotide probes revealed that identification of the bacteria was also possible. Evaluation of this methodology using stored specimens from the kinetic study, showed that bacteria which had grown in blood products could be detected in 2 to 3 days for PCs and in 6 to 9 days for RCCs. Whilst these results matched our preferred time-frame, the sensitivity of detection was reduced in comparison to directly spiked samples. This reduced sensitivity may have been a consequence of long-term storage of the test samples.
In conclusion, this study has shown that screening of blood products for bacteria using a universal PCR is feasible and practicable, and can be performed within a time frame required by the transfusion industry.
Subjects/Keywords: Blood products; Blood
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APA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
List, S. (2005). Methods to detect bacterial contamination of blood products. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/20600/1/whole_ListSarah2005_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
List, SS. “Methods to detect bacterial contamination of blood products.” 2005. Thesis, University of Tasmania. Accessed March 07, 2021.
https://eprints.utas.edu.au/20600/1/whole_ListSarah2005_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
List, SS. “Methods to detect bacterial contamination of blood products.” 2005. Web. 07 Mar 2021.
Vancouver:
List S. Methods to detect bacterial contamination of blood products. [Internet] [Thesis]. University of Tasmania; 2005. [cited 2021 Mar 07].
Available from: https://eprints.utas.edu.au/20600/1/whole_ListSarah2005_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
List S. Methods to detect bacterial contamination of blood products. [Thesis]. University of Tasmania; 2005. Available from: https://eprints.utas.edu.au/20600/1/whole_ListSarah2005_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of North Texas
15.
Jonnada, Srikanth.
Cuff-less Blood Pressure Measurement Using a Smart Phone.
Degree: 2012, University of North Texas
URL: https://digital.library.unt.edu/ark:/67531/metadc115102/
► Blood pressure is vital sign information that physicians often need as preliminary data for immediate intervention during emergency situations or for regular monitoring of people…
(more)
▼ Blood pressure is vital sign information that physicians often need as preliminary data for immediate intervention during emergency situations or for regular monitoring of people with cardiovascular diseases. Despite the availability of portable
blood pressure meters in the market, they are not regularly carried by people, creating a need for an ultra-portable measurement platform or device that can be easily carried and used at all times. One such device is the smartphone which, according to comScore survey is used by 26.2% of the US adult population. the mass production of these phones with built-in sensors and high computation power has created numerous possibilities for application development in different domains including biomedical. Motivated by this capability and their extensive usage, this thesis focuses on developing a
blood pressure measurement platform on smartphones. Specifically, I developed a
blood pressure measurement system on a smart phone using the built-in camera and a customized external microphone. the system consists of first obtaining heart beats using the microphone and finger pulse with the camera, and finally calculating the
blood pressure using the recorded data. I developed techniques for finding the best location for obtaining the data, making the system usable by all categories of people. the proposed system resulted in accuracies between 90-100%, when compared to traditional
blood pressure meters. the second part of this thesis presents a new system for remote heart beat monitoring using the smart phone. with the proposed system, heart beats can be transferred live by patients and monitored by physicians remotely for diagnosis. the proposed
blood pressure measurement and remote monitoring systems will be able to facilitate information acquisition and decision making by the 9-1-1 operators.
Advisors/Committee Members: Dantu, Ram, Sweany, Philip H., Mikler, Armin R..
Subjects/Keywords: Blood pressure; blood pressure estimation; smartphones
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Michigan State University
16.
Wang, Yimeng.
Effects of hyperglycemia on red blood cell storage lesion in transfusion medicine.
Degree: 2013, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:2463
► Thesis Ph. D. Michigan State University. Chemistry - Doctor of Philosophy 2013.
Red blood cell (RBC) transfusions are an important component of critical healthcare. RBCs…
(more)
▼ Thesis Ph. D. Michigan State University. Chemistry - Doctor of Philosophy 2013.
Red blood cell (RBC) transfusions are an important component of critical healthcare. RBCs can be donated, processed, and stored in a blood bank for future transfusion. A review of RBC storage development, as well as RBC storage lesion, is presented here. Whole blood is collected into an anticoagulant-nutrient solution such as citrate phosphate dextrose (CPD). The RBCs separated from the plasma and platelets, are then added into an additive solution, such as AS-1, which supports the nutrient needs of the RBCs in storage. The glucose concentrations in CPD and AS-1 are 129 mM and 111 mM, respectively. Thus, the glucose level in this system (estimated > 40 mM) is much higher than the healthy glucose level in vivo (4-6 mM). This dissertation hypothesizes that the hyperglycemic conditions in the current storage system result in some changes in RBCs and thereby have adverse effects on vascular function.In addition to the primary function of oxygen delivery, RBCs can function as a regulator of vascular tone. It is known that adenosine triphosphate (ATP) is released from intact RBCs in response to several stimuli and further stimulates nitric oxide (NO) production in the endothelium lining the blood vessels. This NO functions to relax the smooth muscle cells surrounding circulatory vessels, thereby increasing blood flow and oxygen delivery to the tissues. In order to investigate the effects of hyperglycemia, RBCs were processed and stored in hyperglycemic and normoglycemic conditions. The vascular function and other properties of these cells were then studied.In an in vitro microflow system, the RBCs stored in hyperglycemic conditions resulted in significantly less RBC-derived ATP for 4 weeks than the RBCs in normoglycemic conditions. During the same storage duration, microfluidic technologies enabled measurements of endothelium-derived NO that was stimulated by the ATP release from the stored RBCs. In comparison to normoglycemic solutions, the NO release decreased by more than 25% in the presence of the RBCs stored in the hyperglycemic conditions. Control experiments using inhibitors of ATP release from the RBCs, or ATP binding to the endothelium, strongly suggest that the decreased NO release by the endothelium is directly related to the ability of the stored RBCs to release ATP. Furthermore, the mechanisms behind the effect of hyperglycemia on the ability of RBCs to release ATP were investigated and discussed. It was found that an osmotic imbalance was formed in RBCs in hyperglycemic conditions, which thereby reversibly impaired the ATP release from RBCs. In addition, longer hyperglycemic storage resulted in sorbitol accumulation within RBCs and cell membrane damage in terms of lipid peroxidation, which irreversibly impaired ability of the RBCs to release ATP. Therefore, the transfusion of those stored RBCs would result in inappropriate vasodilation, less blood flow, and insufficient oxygen delivery, which are often associated with…
Advisors/Committee Members: Spence, Dana, Bruening, Merlin, Huang, Xuefei, Hrinczenko, Borys.
Subjects/Keywords: Erythrocytes; Blood – Transfusion; Hyperglycemia; Blood banks; Chemistry
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APA (6th Edition):
Wang, Y. (2013). Effects of hyperglycemia on red blood cell storage lesion in transfusion medicine. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:2463
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Yimeng. “Effects of hyperglycemia on red blood cell storage lesion in transfusion medicine.” 2013. Thesis, Michigan State University. Accessed March 07, 2021.
http://etd.lib.msu.edu/islandora/object/etd:2463.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Yimeng. “Effects of hyperglycemia on red blood cell storage lesion in transfusion medicine.” 2013. Web. 07 Mar 2021.
Vancouver:
Wang Y. Effects of hyperglycemia on red blood cell storage lesion in transfusion medicine. [Internet] [Thesis]. Michigan State University; 2013. [cited 2021 Mar 07].
Available from: http://etd.lib.msu.edu/islandora/object/etd:2463.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang Y. Effects of hyperglycemia on red blood cell storage lesion in transfusion medicine. [Thesis]. Michigan State University; 2013. Available from: http://etd.lib.msu.edu/islandora/object/etd:2463
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
The Ohio State University
17.
Rutkowski, Roman B.
The assay of the human fibrinolytic system.
Degree: PhD, Graduate School, 1964, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486563815674993
Subjects/Keywords: Chemistry; Blood; Blood
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Rutkowski, R. B. (1964). The assay of the human fibrinolytic system. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486563815674993
Chicago Manual of Style (16th Edition):
Rutkowski, Roman B. “The assay of the human fibrinolytic system.” 1964. Doctoral Dissertation, The Ohio State University. Accessed March 07, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1486563815674993.
MLA Handbook (7th Edition):
Rutkowski, Roman B. “The assay of the human fibrinolytic system.” 1964. Web. 07 Mar 2021.
Vancouver:
Rutkowski RB. The assay of the human fibrinolytic system. [Internet] [Doctoral dissertation]. The Ohio State University; 1964. [cited 2021 Mar 07].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486563815674993.
Council of Science Editors:
Rutkowski RB. The assay of the human fibrinolytic system. [Doctoral Dissertation]. The Ohio State University; 1964. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486563815674993
University of Aberdeen
18.
Morrow, Gael Beverley.
Platelets harbour pro- and anti-fibrinolytic proteins on their activated membrane surface that regulate fibrinolysis of thrombi formed under flow.
Degree: PhD, 2018, University of Aberdeen
URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152783650005941
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742397
► Platelets play an essential role in haemostasis by adhering to the damaged vessel wall and forming a platelet plug to arrest bleeding. Although platelets are…
(more)
▼ Platelets play an essential role in haemostasis by adhering to the damaged vessel wall and forming a platelet plug to arrest bleeding. Although platelets are traditionally thought of as pro-coagulant, they possess the ability to harbour functional proteins that are key to fibrinolysis, the breakdown of the blood clot, on their surface. They are therefore substantially well equipped to regulate local fibrinolysis. This thesis aims to further define the role of platelets in fibrinolysis, in particular platelet-derived plasminogen activator inhibitor 1 (PAI-1) and plasminogen. PAI-1 is the principal physiological inhibitor of tissue-type plasminogen activator (tPA), and plasminogen is the zymogen for plasmin. In Chapter 3, we show that platelet-derived PAI-1 is released from platelet α-granules by an αIIbβ3 and fibrin dependent mechanism. We found that a significant portion of α-granular PAI1 is retained on the surface of highly activated PS-positive platelets, and activity analysis revealed the majority of PAI-1 on the platelet surface was in its active form. The functional role of platelet PAI-1 was investigated by analysis of tPA-mediated lysis of Chandler model thrombi. Our data revealed a striking dependence for platelet PAI-1 in stabilising platelet-rich thrombi against degradation. Chapter 4 characterises the expression of a novel transmembrane receptor, Plg-RKT, on the surface of human and mouse platelets. This revealed that plasminogen and Plg-RKT augment one another's binding to the platelet surface. Furthermore, analysis of plasminogen binding to the platelet surface revealed two distinct binding sites: 1) via Plg-RKT and 2) via a fibrin and αIIbβ3 dependent mechanism. Finally, Chapter 5 of this thesis discusses the optimisation of a system that monitors thrombus formation and fibrinolysis under flow. Use of this model will help to further elucidate the complex role that platelets play in controlling the balance between coagulation and fibrinolysis.
Subjects/Keywords: 610; Blood platelets; Blood; Fibrinogen; Hemostasis
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APA ·
Chicago ·
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CSE |
Export
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Manager
APA (6th Edition):
Morrow, G. B. (2018). Platelets harbour pro- and anti-fibrinolytic proteins on their activated membrane surface that regulate fibrinolysis of thrombi formed under flow. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152783650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742397
Chicago Manual of Style (16th Edition):
Morrow, Gael Beverley. “Platelets harbour pro- and anti-fibrinolytic proteins on their activated membrane surface that regulate fibrinolysis of thrombi formed under flow.” 2018. Doctoral Dissertation, University of Aberdeen. Accessed March 07, 2021.
https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152783650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742397.
MLA Handbook (7th Edition):
Morrow, Gael Beverley. “Platelets harbour pro- and anti-fibrinolytic proteins on their activated membrane surface that regulate fibrinolysis of thrombi formed under flow.” 2018. Web. 07 Mar 2021.
Vancouver:
Morrow GB. Platelets harbour pro- and anti-fibrinolytic proteins on their activated membrane surface that regulate fibrinolysis of thrombi formed under flow. [Internet] [Doctoral dissertation]. University of Aberdeen; 2018. [cited 2021 Mar 07].
Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152783650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742397.
Council of Science Editors:
Morrow GB. Platelets harbour pro- and anti-fibrinolytic proteins on their activated membrane surface that regulate fibrinolysis of thrombi formed under flow. [Doctoral Dissertation]. University of Aberdeen; 2018. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152783650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.742397
19.
Laxmidhar Maharana.
Investigation of the hypoglycemic/antidiabetic potential
and toxicity profile of some plants in control of blood glucose
level in experimental animal models; -.
Degree: pharmacy, 2011, Shiksha o Anusandhan University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/8511
► Diabetes mellitus is a major heterogeneous endocrine and metabolic disorder, characterized by altered metabolism of carbohydrate, lipid and protein, which leads to hyperglycaemia and causes…
(more)
▼ Diabetes mellitus is a major heterogeneous
endocrine and metabolic disorder, characterized by altered
metabolism of carbohydrate, lipid and protein, which leads to
hyperglycaemia and causes many physiological complications, such as
hyperlipidemia, hypertension and atherosclerosis. The global
prevalence of diabetes among adults as per WHO, was estimated at
150 million in 1995, and this is projected to increase to 300
million by 2025. The oxidative stress, caused by free radicals
induced by hyperglycemia, contributes to the development and
progression of diabetes along with secondary complications. The
plants containing natural antioxidants (tannins, flavonoids,
vitamin C and E, etc.) that can preserve and#946;-cell function and
prevent diabetes induced ROS formation and many plant species are
known in folk medicine of different cultures to be used for their
hypoglycaemic properties and therefore used for treatment of DM
(Abdel-Barry et al., 1997; Pushparaj et al., 2000). Despite this,
few traditionally used antidiabetic plants have received proper
scientific screening (Bakirel et al, 2008). The World Health
Organization (WHO) has recommended that this area warrants further
evaluation (WHO, 1980). Solanum nigrum Linn. (Solanaceae) commonly
known as Black Berried Nightshade found in disturbed habitats,
distributed throughout India. The leaves are reported to contain
several constituents e.g. flavonols like Quercetin, Hyperoside,
Steroids and alkaloids etc. The Kondh tribes of Orissa, India use
the hot aqueous extract of the fruits and leaves as a folk medicine
for the treatment of diabetes mellitus. newlineMollugo pentaphylla
Linn. commonly known as carpet weed (English), Pitta saga (Oriya)
is a perennial herb found throughout India. The plant is reported
to contain Flavones such as Apigenin and Mollupentin, Mollugogenol
A, an antifungal triterpenoid, Mollugogenol B, Mollugogenol D,
Oleanolic acid and a steroid Beta Sitosterol.
References p.223-263
Advisors/Committee Members: Sudam, Chandra Si, Sahu, Pratap Kumar.
Subjects/Keywords: pharmacy; blood glucose
Record Details
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APA ·
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Export
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Manager
APA (6th Edition):
Maharana, L. (2011). Investigation of the hypoglycemic/antidiabetic potential
and toxicity profile of some plants in control of blood glucose
level in experimental animal models; -. (Thesis). Shiksha o Anusandhan University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/8511
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Maharana, Laxmidhar. “Investigation of the hypoglycemic/antidiabetic potential
and toxicity profile of some plants in control of blood glucose
level in experimental animal models; -.” 2011. Thesis, Shiksha o Anusandhan University. Accessed March 07, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/8511.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Maharana, Laxmidhar. “Investigation of the hypoglycemic/antidiabetic potential
and toxicity profile of some plants in control of blood glucose
level in experimental animal models; -.” 2011. Web. 07 Mar 2021.
Vancouver:
Maharana L. Investigation of the hypoglycemic/antidiabetic potential
and toxicity profile of some plants in control of blood glucose
level in experimental animal models; -. [Internet] [Thesis]. Shiksha o Anusandhan University; 2011. [cited 2021 Mar 07].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/8511.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Maharana L. Investigation of the hypoglycemic/antidiabetic potential
and toxicity profile of some plants in control of blood glucose
level in experimental animal models; -. [Thesis]. Shiksha o Anusandhan University; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/8511
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
Sunday, Joyce Chinonso.
Ontogeny of Matrix Metalloproteinases (MMP-2, 8, 9 and 13)
and Tissue inhibitors of Metalloproteinases (TIMP-1, 2, 3 and 4) in
Cerebral Cortex of Sheep.
Degree: Department of Molecular Pharmacology, Physiology and
Biotechnology, 2018, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:792877/
► Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are essential for ECM remodeling and the development of the blood-brain barrier. Studies suggest that MMPs…
(more)
▼ Matrix metalloproteinases (MMPs) and tissue inhibitors
of metalloproteinases (TIMPs) are essential for ECM remodeling and
the development of the
blood-brain barrier. Studies suggest that
MMPs and TIMPs play a significant role in neurogenesis, brain
maturation and degradation of extracellular matrix proteins. The
goal of this study is to determine the ontogenic pattern of MMP-2,
MMP-8, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3 and TIMP-4 in the
cerebral cortex fetal, newborn and adult sheep. Western immunoblot
was used to measure MMPs and TIMPs in cerebral cortices of fetuses
at 60%, 80%, and 90% of gestation, in newborn and adult sheep.
MMP-2 and MMP-9 activity and expression exhibited ontogenic
increases, whereas MMP-8 did not display the same pattern of
expression. The protein expression of MMP-13 was higher (P<0.05)
in newborn and adult sheep than in fetal sheep at 60% and 70% of
gestation. TIMPs 1 and 3 did not show quantitate changes during
maturation. TIMP-2 expression was lowest in fetuses at 60%
gestation, whereas TIMP-4 was higher during early fetal gestation.
The findings suggest the important role of MMPs and TIMPs in
neuronal differentiation and brain remodeling during development.
This study will provide basis for future exploration into the role
of MMPs and TIMPs in the brain during development and perinatal
brain injury.
Advisors/Committee Members: Zielinski-Habershaw, Beth (Reader), Chen, Xiaodi (Reader), Stonestreet, Barbara (Advisor).
Subjects/Keywords: Blood-brain barrier
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APA ·
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Manager
APA (6th Edition):
Sunday, J. C. (2018). Ontogeny of Matrix Metalloproteinases (MMP-2, 8, 9 and 13)
and Tissue inhibitors of Metalloproteinases (TIMP-1, 2, 3 and 4) in
Cerebral Cortex of Sheep. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792877/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sunday, Joyce Chinonso. “Ontogeny of Matrix Metalloproteinases (MMP-2, 8, 9 and 13)
and Tissue inhibitors of Metalloproteinases (TIMP-1, 2, 3 and 4) in
Cerebral Cortex of Sheep.” 2018. Thesis, Brown University. Accessed March 07, 2021.
https://repository.library.brown.edu/studio/item/bdr:792877/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sunday, Joyce Chinonso. “Ontogeny of Matrix Metalloproteinases (MMP-2, 8, 9 and 13)
and Tissue inhibitors of Metalloproteinases (TIMP-1, 2, 3 and 4) in
Cerebral Cortex of Sheep.” 2018. Web. 07 Mar 2021.
Vancouver:
Sunday JC. Ontogeny of Matrix Metalloproteinases (MMP-2, 8, 9 and 13)
and Tissue inhibitors of Metalloproteinases (TIMP-1, 2, 3 and 4) in
Cerebral Cortex of Sheep. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Mar 07].
Available from: https://repository.library.brown.edu/studio/item/bdr:792877/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sunday JC. Ontogeny of Matrix Metalloproteinases (MMP-2, 8, 9 and 13)
and Tissue inhibitors of Metalloproteinases (TIMP-1, 2, 3 and 4) in
Cerebral Cortex of Sheep. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792877/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
21.
Van Tonder, Jarne Stefan.
The efficacy of Arnica montana 30CH and 200CH to thrombolise a blood clot in an in-vitro sample.
Degree: 2012, University of Johannesburg
URL: http://hdl.handle.net/10210/4604
► M.Tech.
Coagulation or the formation of blood clots is the result of several complex interactions between humoral coagulation factors, platelets, and fibrin. Unnatural or excessive…
(more)
▼ M.Tech.
Coagulation or the formation of blood clots is the result of several complex interactions between humoral coagulation factors, platelets, and fibrin. Unnatural or excessive coagulation is inhibited by the fibrinolytic system. In normal homeostasis, there is a dynamic state in which thrombi are constantly being formed and removed from the circulatory system. Fibrin being the main component of a blood clot is formed by the activation of the clotting cascade. Its production is followed by the fibrinolytic system, resulting in plasmin generation and subsequent fibrin degradation (Soria et al., 1983). Plasmin is the enzyme responsible for fibrin degradation. It is derived from its inactive precursor, plasminogen, by the action of thrombin and plasminogen activators. Homoeopathic Arnica montana is prescribed for pathological conditions that have a sudden onset, are traumatic in nature, and result from the complications of the initial trauma (Vermeulen, 1997). It has been prescribed for various thrombotic disorders and it is known that it speeds up healing and revascularisation of the surrounding tissue (Savage and Roe, 1977). It is a short acting homoeopathic medication, and needs to be repeated often, but it is quick in its actions (Gordon Ross, 1977). This study aimed to establish if Arnica montana 30CH and 200CH potencies caused thrombolysis of a blood clot within an in-vitro sample. It was hypothesised that Arnica montana in 30CH and 200CH potencies would cause thrombolysis in- vitro. The research sample group consisted of fifteen male participants, between eighteen and thirty years of age. Only male participants were selected to prevent any gender variables that may influence the study. Four blood samples each consisting of five milliliters was taken from each participant. Current and efficient phlebotomy techniques were used and the samples were placed in non-treated plastic phlebotomy containers to allow speedy clot formation. One sample was treated with one drop of 30CH Arnica montana and the other with one drop of 200CH Arnica montana. The third sample for each subject was used as a control where one drop of 0.9% sterile saline was added. Thus, consistency concerning diluting effects was maintained. D-dimer levels were measured using the D-DI Test from Diagnostica Stago, which is a rapid latex agglutination slide test. A semi-quantitative testing mode was used to gather the relevant research information. The results of the study showed that in all the samples tested, no agglutination of D-dimers occurred. This indicated that if thrombolysis occurred in the samples, a D-dimer level well below 0.5 micrograms per milliliter of FEU occurred. It has been established that as separate entities homoeopathic Arnica montana 30CH and 200CH have little or no direct effect on a clotted in-vitro sample. This indicates that if the medicine has thrombolytic properties, it has to utilize or activate other endogenous factors in-vivo. As these factors require the presence of vascular endothelium, it makes it potentially…
Subjects/Keywords: Blood coagulation; Homeopathy
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APA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Van Tonder, J. S. (2012). The efficacy of Arnica montana 30CH and 200CH to thrombolise a blood clot in an in-vitro sample. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/4604
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Van Tonder, Jarne Stefan. “The efficacy of Arnica montana 30CH and 200CH to thrombolise a blood clot in an in-vitro sample.” 2012. Thesis, University of Johannesburg. Accessed March 07, 2021.
http://hdl.handle.net/10210/4604.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Van Tonder, Jarne Stefan. “The efficacy of Arnica montana 30CH and 200CH to thrombolise a blood clot in an in-vitro sample.” 2012. Web. 07 Mar 2021.
Vancouver:
Van Tonder JS. The efficacy of Arnica montana 30CH and 200CH to thrombolise a blood clot in an in-vitro sample. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10210/4604.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Van Tonder JS. The efficacy of Arnica montana 30CH and 200CH to thrombolise a blood clot in an in-vitro sample. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/4604
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
22.
Motala, Vicky Ayesha.
A pilot study on the effect of a homoeopathic remedy Arnica montana 12 CH on blood coagulation.
Degree: 2014, University of Johannesburg
URL: http://hdl.handle.net/10210/10658
► M.Tech. (Homoeopathy)
The purpose of this study was to determine the effect of the Homoeopathic remedy Arnica montana 12 CH on blood coagulation. For years…
(more)
▼ M.Tech. (Homoeopathy)
The purpose of this study was to determine the effect of the Homoeopathic remedy Arnica montana 12 CH on blood coagulation. For years Arnica montana has been used to treat injuries where there is bleeding and bruising. The arrest of bleeding is accomplished by a number of mechanisms,one of which is blood coagulation. The study was conducted using 21 volunteers with each person acting as his or her own control Two blood samples were collected from each patient over a three day period. After preparing fresh whole blood samples and platelet-poor plasma, full blood count and coagulation assays were run using the Cell-Dyn 1700 system and the Automated Coagulation Laboratory analyser respectively. The average from the two days were calculated and statistically analysed using the Two way ANDVA method of analysis. Results showed that the differences between the experimental group and the control group were too small to be statistically significant. This showed that Arnica montana 12 CH had no significant effect on blood coagulation. It is interesting to note that the alcohol group had almost the same results as the experimental group.
Subjects/Keywords: Homeopathy; Blood - Coagulation
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Motala, V. A. (2014). A pilot study on the effect of a homoeopathic remedy Arnica montana 12 CH on blood coagulation. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/10658
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Motala, Vicky Ayesha. “A pilot study on the effect of a homoeopathic remedy Arnica montana 12 CH on blood coagulation.” 2014. Thesis, University of Johannesburg. Accessed March 07, 2021.
http://hdl.handle.net/10210/10658.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Motala, Vicky Ayesha. “A pilot study on the effect of a homoeopathic remedy Arnica montana 12 CH on blood coagulation.” 2014. Web. 07 Mar 2021.
Vancouver:
Motala VA. A pilot study on the effect of a homoeopathic remedy Arnica montana 12 CH on blood coagulation. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10210/10658.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Motala VA. A pilot study on the effect of a homoeopathic remedy Arnica montana 12 CH on blood coagulation. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/10658
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Ottawa
23.
Perelman, Iris.
The Epidemiology of Multiple Blood Component Transfusion
.
Degree: 2019, University of Ottawa
URL: http://hdl.handle.net/10393/38867
► Multicomponent transfusion, or the transfusion of two or more different blood products, has been poorly studied to date, as most of the existing literature has…
(more)
▼ Multicomponent transfusion, or the transfusion of two or more different blood products, has been poorly studied to date, as most of the existing literature has focused on the use of individual blood products. This is of concern as multicomponent transfusion recipients likely differ with respect to characteristics and health outcomes from patients transfused with only one type of blood component (e.g. greater illness severity). Consequently, available data on individual blood product use and outcomes may not be applicable to multicomponent transfused patients. This thesis project identified and synthesized existing literature on the epidemiology of multicomponent transfusion in hospital inpatients, as well as the characteristics and outcomes of its recipients. Based on 37 observational studies, we found that the prevalence of multicomponent transfusion varied greatly by patient population, transfusion timeframe, and type of multicomponent transfusion being studied. The most common types of multicomponent transfusion across the 37 studies were co-transfusions of red blood cells (RBCs) and platelets, and co-transfusions of RBCs and plasma. Multicomponent transfusion was found to be associated with several negative health outcomes, however this was based on low quality evidence due to lack of control for confounding by indication. Our systematic review on multicomponent transfusion identified several knowledge gaps, including the need for studies focusing on patients with hematological malignancies, and studies identifying patient characteristics predictive of multicomponent transfusion. To address areas of knowledge deficiency, and to characterize multicomponent transfusion locally at our own center, we designed and conducted a retrospective cohort study of adult, transfused hospital inpatients. Based on 55,719 transfused inpatient admissions at the Ottawa Hospital between 2007 and 2017, we calculated the overall prevalence of multicomponent transfusion to be 25.1% (95% CI: 24.7%, 25.5%). Similar to the findings of our systematic review, the prevalence varied greatly by patient type, transfusion timeframe, and type of multicomponent transfusion. In particular, in hematology patients, the prevalence of multicomponent transfusion was 51%. Other patient groups frequently receiving multicomponent transfusions at our institution were cardiac surgery, critical care, cardiology, vascular surgery, trauma, surgery, and internal medicine patients. Using multivariable regression analysis, we found that patient sex, age, and type were predictive of multicomponent transfusion requirement. Additionally, controlling for illness severity and burden, multicomponent transfusion was associated with increased odds of in-hospital mortality, institutional discharge compared to discharge home, and greater length of hospital stay compared to patients transfused with only RBCs. Given our findings that multicomponent transfusion recipients make up a large proportion of transfused hospital patients, and that they have poorer outcomes, it is of…
Subjects/Keywords: Blood transfusion;
Epidemiology
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APA (6th Edition):
Perelman, I. (2019). The Epidemiology of Multiple Blood Component Transfusion
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/38867
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Perelman, Iris. “The Epidemiology of Multiple Blood Component Transfusion
.” 2019. Thesis, University of Ottawa. Accessed March 07, 2021.
http://hdl.handle.net/10393/38867.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Perelman, Iris. “The Epidemiology of Multiple Blood Component Transfusion
.” 2019. Web. 07 Mar 2021.
Vancouver:
Perelman I. The Epidemiology of Multiple Blood Component Transfusion
. [Internet] [Thesis]. University of Ottawa; 2019. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10393/38867.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Perelman I. The Epidemiology of Multiple Blood Component Transfusion
. [Thesis]. University of Ottawa; 2019. Available from: http://hdl.handle.net/10393/38867
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Wake Forest University
24.
Liu, Chen.
THE ROLE OF NITRIC OXIDE IN THE BLOOD STORAGE LESION.
Degree: 2013, Wake Forest University
URL: http://hdl.handle.net/10339/39112
► The blood storage lesion refers to changes in red blood cells (RBCs) during storage. It includes a number of chemical and morphological changes in RBCs,…
(more)
▼ The blood storage lesion refers to changes in red blood cells (RBCs) during storage. It includes a number of chemical and morphological changes in RBCs, which result in reduced integrity of the erythrocyte membrane with formation of microparticles, and increased cell-free hemoglobin in plasma. The geometry of the red blood cell tends to become more spherical, the mean cell hemoglobin concentration (MCHC) in RBCs decreases, RBC volume varies, and the structure of RBC membrane changes significantly. The adverse effects associated with the blood storage lesion are under investigation. We hypothesize that increased nitric oxide (NO) scavenging due to red cell breakdown contributes to the blood storage lesion. In this study, we examined the rate of cell-free hemoglobin and microparticles reacting with NO and found that microparticles scavenge NO only 3 times slower than cell-free hemoglobin but still about 1000 times faster than RBCs. Thus, release of cell-free hemoglobin and microparticles during storage and post transfusion reduces NO bioavailability. We further explored factors that would determine the extent to which red cell microparticles contribute to NO scavenging, such as the ability of these microparticles to concentrate in the cell free zone. We found that microparticles, like cell-free hemoglobin, enter the cell-free zone and as little as 5 µM hemoglobin encapsulated in microparticles has the potential to reduce NO bioavailability and impair endothelial-dependent vasodilation. Additionally, we examined the rate of NO scavenging by fresh and old stored RBCs and found that old stored RBCs scavenge NO about 2 times faster than fresh stored RBCs. In order to understand the mechanisms of increased NO scavenging by older stored RBCs, we simulated NO scavenging by RBCs using 3D single RBC models. Our work shows that the rate of NO scavenging by RBCs increases as RBC MCHC or volume decreases. RBC membrane permeability needs to increase 5 to 70 fold to compensate the effect of geometry and explain our experimental findings. In summary, we have elucidated the extent and mechanisms of reduced NO bioavailability due to red cell breakdown thereby establishing how it contributes to pathological consequences of the storage lesion.
Subjects/Keywords: Blood storage lesion
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APA (6th Edition):
Liu, C. (2013). THE ROLE OF NITRIC OXIDE IN THE BLOOD STORAGE LESION. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/39112
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Liu, Chen. “THE ROLE OF NITRIC OXIDE IN THE BLOOD STORAGE LESION.” 2013. Thesis, Wake Forest University. Accessed March 07, 2021.
http://hdl.handle.net/10339/39112.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Liu, Chen. “THE ROLE OF NITRIC OXIDE IN THE BLOOD STORAGE LESION.” 2013. Web. 07 Mar 2021.
Vancouver:
Liu C. THE ROLE OF NITRIC OXIDE IN THE BLOOD STORAGE LESION. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10339/39112.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Liu C. THE ROLE OF NITRIC OXIDE IN THE BLOOD STORAGE LESION. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/39112
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Oregon State University
25.
Lusianti, Ratih E.
Improving the post-thaw processing of cryopreserved red blood cells using a combined approach of mathematical modeling and microfluidics.
Degree: PhD, Chemical Engineering, 2014, Oregon State University
URL: http://hdl.handle.net/1957/46826
► This study lays the groundwork on potential techniques that could be employed to improve the post-thaw wash processing of cryopreserved human red blood cells. Transfusion…
(more)
▼ This study lays the groundwork on potential techniques that could be employed to improve the post-thaw wash processing of cryopreserved human red
blood cells. Transfusion of red
blood cells is one of the most commonly practiced procedures in clinical medicine. Millions of red
blood cell units are transfused to patients every year. The current method of preservation of red
blood cells only allows a short refrigerated shelf life of 6 weeks, which causes logistical issues and frequent shortages during the time when donor availability is decreased. Cryopreserving red
blood cells in the presence of 40% w/v glycerol extends the stable shelf life of red
blood cells to 10 years. The long stable shelf life allows stockpiling of transfusable RBC units. Although this preservation method is clinically approved and routinely performed, the use of cryopreservation in
blood banking is limited to only autologous and rare units. One of the main reasons for this limitation is the time consuming post-thaw wash process required to remove the glycerol before the unit can be used for transfusion. The need to plan the amount of
washed units makes the use of cryopreserved red
blood cells for unscheduled transfusion particularly challenging. In this work, we have attempted to improve the efficiency of the post-thaw removal process by using modern scientific approaches. Using the mathematical model for cell membrane transport, we have demonstrated that glycerol can be rapidly extracted from red
blood cells without excessively damaging the cell membrane in a batch process. This rapid glycerol removal approach was then applied into a membrane based microfluidic platform for adaptation into an efficient continuous process. A mathematical model of the membrane based microfluidic device capable of predicting the transport of water and solutes was developed to assist in the design of an efficient deglycerolization process. Glycerol removal experiments using a prototype of the device validated model predictions and demonstrated successful partial continuous deglycerolization of cryopreserved red
blood cells. Simulations generated using the mathematical model shows that it is possible to rapidly deglycerolize cryopreserved red
blood cells in a continuous process to levels acceptable for transfusion. With the potential for efficient continuous post-thaw wash processing, it is hoped that cryopreserved red
blood cells may become a more attractive option for use in clinical therapy
Advisors/Committee Members: Higgins, Adam Z. (advisor), McGuire, Joseph (committee member).
Subjects/Keywords: Blood cells – Cryopreservation
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APA (6th Edition):
Lusianti, R. E. (2014). Improving the post-thaw processing of cryopreserved red blood cells using a combined approach of mathematical modeling and microfluidics. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/46826
Chicago Manual of Style (16th Edition):
Lusianti, Ratih E. “Improving the post-thaw processing of cryopreserved red blood cells using a combined approach of mathematical modeling and microfluidics.” 2014. Doctoral Dissertation, Oregon State University. Accessed March 07, 2021.
http://hdl.handle.net/1957/46826.
MLA Handbook (7th Edition):
Lusianti, Ratih E. “Improving the post-thaw processing of cryopreserved red blood cells using a combined approach of mathematical modeling and microfluidics.” 2014. Web. 07 Mar 2021.
Vancouver:
Lusianti RE. Improving the post-thaw processing of cryopreserved red blood cells using a combined approach of mathematical modeling and microfluidics. [Internet] [Doctoral dissertation]. Oregon State University; 2014. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1957/46826.
Council of Science Editors:
Lusianti RE. Improving the post-thaw processing of cryopreserved red blood cells using a combined approach of mathematical modeling and microfluidics. [Doctoral Dissertation]. Oregon State University; 2014. Available from: http://hdl.handle.net/1957/46826
University of Toronto
26.
Dryden, OmiSoore H.
Unrepresentable Blood: Canadian Blood Donation, “Gay Blood” and the Queerness of Blackness.
Degree: PhD, 2016, University of Toronto
URL: http://hdl.handle.net/1807/89242
► In this dissertation, I explore the Canadian Blood Services blood donation questionnaire and how the blood stories assembled within this document, and in the larger…
(more)
▼ In this dissertation, I explore the Canadian Blood Services blood donation questionnaire and how the blood stories assembled within this document, and in the larger blood system, intersect with and depict blackness, queer (diaspora) sexualities, and Canadian (homo)nation-making. Narratives on blood produce moments of discipline, regulation, and confinement. Canadian Blood Services argues that its donor questionnaire is designed to effectively screen potential blood donors, with a number of questions focused on preventing an HIV/AIDS outbreak in the general population. The information gathered from these diverse questions constructs a figure of the ideal blood donor, thus creating a distinction between people whose blood gives life and people whose blood brings death. These distinctions result in the ban of particular groups of people, including bisexual and gay men and African people.
Through centring a black queer diasporic analytic and reading practice, I am able to interrogate the ontological problem made of blackness. I contend that queerer modalities of thought are necessary to account for the complicated realities of racialized sexuality lived through black queered bodies and by black queer and trans people (and their blood).
I analyze a diverse set of archives, including the donor questionnaire; websites of social and political organizations involved in the gay-blood debates; and legal, news, and government documents pertaining to the Canadian blood system. I seek to break the public silence on how blood continues to be used to justify the denigration of the lives of black people, both inside and outside of gay spaces, to push against the narrow, normative Eurocentric structures of gay blood. Thus, this reading acts as a decolonial, diasporic, transgressive project of writing blackness. My intervention into these anti-normative, anti-colonial discussions of blood, queerness, and blackness engages in a form of â epistemic disobedienceâ necessary to think differently about and disrupt both the homonationalist framing of gay blood and, more importantly, how we envision queer communities in our diasporic home-making. It is this that I seek to provoke in this thesis: to bring together the tangible and incoherent realities of our lives in order to articulate and engage in transformative justice.
2018-07-06 00:00:00
Advisors/Committee Members: Walcott, Rinaldo W, Social Justice Education.
Subjects/Keywords: African/Black blood; Black Queer Diaspora; Blood donation; Blood narratives; Gay Blood; Transnational blackness; 0492
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Manager
APA (6th Edition):
Dryden, O. H. (2016). Unrepresentable Blood: Canadian Blood Donation, “Gay Blood” and the Queerness of Blackness. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89242
Chicago Manual of Style (16th Edition):
Dryden, OmiSoore H. “Unrepresentable Blood: Canadian Blood Donation, “Gay Blood” and the Queerness of Blackness.” 2016. Doctoral Dissertation, University of Toronto. Accessed March 07, 2021.
http://hdl.handle.net/1807/89242.
MLA Handbook (7th Edition):
Dryden, OmiSoore H. “Unrepresentable Blood: Canadian Blood Donation, “Gay Blood” and the Queerness of Blackness.” 2016. Web. 07 Mar 2021.
Vancouver:
Dryden OH. Unrepresentable Blood: Canadian Blood Donation, “Gay Blood” and the Queerness of Blackness. [Internet] [Doctoral dissertation]. University of Toronto; 2016. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1807/89242.
Council of Science Editors:
Dryden OH. Unrepresentable Blood: Canadian Blood Donation, “Gay Blood” and the Queerness of Blackness. [Doctoral Dissertation]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/89242
University of Texas – Austin
27.
Stray-Gundersen, Sten Oliver.
Walking with leg blood flow restriction : wide-rigid cuffs vs. narrow-elastic bands.
Degree: MSin Kinesiology, Kinesiology, 2019, University of Texas – Austin
URL: http://dx.doi.org/10.26153/tsw/5686
► Blood flow restriction (BFR) training is becoming a popular form of exercise. The concept is that light-load exercise performed with BFR elicits similar adaptations achieved…
(more)
▼ Blood flow restriction (BFR) training is becoming a popular form of exercise. The concept is that light-load exercise performed with BFR elicits similar adaptations achieved with traditional heavy-load exercise. Walking exercise in combination with pressurized wide-rigid (WR) cuffs elicits higher cardiac workload and a vascular dysfunction due presumably to reperfusion injury to the endothelium. In contrast, narrow-elastic (NE) BFR bands may elicit different hemodynamic effects, as the limb is able to increase in diameter with increased
blood flow accompanying exercise. Purpose: To compare the acute cardiovascular responses to two distinct forms of BFR training during light-intensity exercise. Methods: 15 young healthy participants (M=9, F=6) performed 5 bouts of 2-minute walking intervals at 0.9 m/s with a 1-minute rest and deflation period between bouts with either WR, NE, or no bands placed on both upper thighs. Cuff pressure was inflated to 160 mmHg in WR cuffs and 300 mmHg in NE bands while no cuffs were used for the control. Beat-by-beat
blood pressure and heart rate were measured continuously using finger plethysmography.
Blood lactate concentration, rating of perceived exertion (RPE), flow-mediated dilation (index of endothelium-dependent vasodilation), and cardio-ankle vascular index (measure of arterial stiffness) were assessed before and after the walking exercise. Results: At baseline, no significant differences existed in any of the variables between the three conditions. Increases in heart rate were greater (p<0.05) in the WR than the NE and control conditions. Increases in systolic and diastolic
blood pressure were greater (p<0.05) in the WR than the NE and control conditions, and increases in systolic
blood pressure were greater (p<0.05) in the control than the NE condition (150±16 / 85±15 mmHg vs. 127±10 / 66±12 mmHg vs. 130±15 / 66±13 mmHg, respectively). Double product, an index of myocardial oxygen demand, increased to a greater extent in the WR than in the NE and control conditions, and to a greater extent in the control than the NE condition. Increases in perceived exertion and
blood lactate concentration were greater (p<0.05) in the WR compared with the NE and control conditions (p<0.05), while no differences were seen between the NE and control conditions. There were no changes (p>0.05) in arterial stiffness or endothelial function in all three trials. Conclusion: Use of wide-rigid BFR cuffs result in a marked increase in
blood pressure and myocardial oxygen demand compared with narrow-elastic BFR bands, suggesting that narrow-elastic bands present a safer alternative for at-risk populations to perform BFR exercise.
Advisors/Committee Members: Tanaka, Hirofumi, Ph. D. (advisor).
Subjects/Keywords: Blood flow restriction
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APA (6th Edition):
Stray-Gundersen, S. O. (2019). Walking with leg blood flow restriction : wide-rigid cuffs vs. narrow-elastic bands. (Masters Thesis). University of Texas – Austin. Retrieved from http://dx.doi.org/10.26153/tsw/5686
Chicago Manual of Style (16th Edition):
Stray-Gundersen, Sten Oliver. “Walking with leg blood flow restriction : wide-rigid cuffs vs. narrow-elastic bands.” 2019. Masters Thesis, University of Texas – Austin. Accessed March 07, 2021.
http://dx.doi.org/10.26153/tsw/5686.
MLA Handbook (7th Edition):
Stray-Gundersen, Sten Oliver. “Walking with leg blood flow restriction : wide-rigid cuffs vs. narrow-elastic bands.” 2019. Web. 07 Mar 2021.
Vancouver:
Stray-Gundersen SO. Walking with leg blood flow restriction : wide-rigid cuffs vs. narrow-elastic bands. [Internet] [Masters thesis]. University of Texas – Austin; 2019. [cited 2021 Mar 07].
Available from: http://dx.doi.org/10.26153/tsw/5686.
Council of Science Editors:
Stray-Gundersen SO. Walking with leg blood flow restriction : wide-rigid cuffs vs. narrow-elastic bands. [Masters Thesis]. University of Texas – Austin; 2019. Available from: http://dx.doi.org/10.26153/tsw/5686
University of Manchester
28.
Brown, Benjamin Scott.
Diagnosis of Hepatitis C Using Dried Blood
Spots.
Degree: 2020, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326122
► Hepatitis C virus (HCV) is a major worldwide health issue, infecting approximately 71.1 million people worldwide, with 143 000 thought to be chronically infected in…
(more)
▼ Hepatitis C virus (HCV) is a major worldwide health
issue, infecting approximately 71.1 million people worldwide, with
143 000 thought to be chronically infected in England. The vast
majority of these (92.1%) infections are found in injecting drug
users. A major breakthrough in screening has been achieved in the
past few years with the introduction of increased screening for
HCV, specifically targeting the injecting drug user population.
Dried
blood spots were shown to be a suitable sample type to use in
these circumstances, overcoming previous issues caused by poor
venous access and limited availability of sufficiently trained
phlebotomists and increasing testing in this population. Despite
the improvements brought about through the use of this sample type
several issues still remain including: - A large population of
injecting drug users are still unaware of their hepatitis C
infection. - Testing from dried
blood spots uses commercial CE
marked HCV serological assays, but these assays are not CE marked
for use with dried
blood spots. - Optimisation of commercial assays
has increased the sensitivity achievable from dried
blood spots to
a high level (97-100%) this does not match that available from
serum samples. Only an assay specifically designed for dried
blood
spot samples will be able to increase the sensitivity past what is
currently achievable. - Reliable identification of acute HCV
infection is not currently possible. The HCV Core, NS3, NS4, NS5a
and NS5b proteins were produced using flashBACâ„¢ ultra baculovirus
expression system. Low protein yield in NS4, NS5a and NS5b protein
production was overcome with the use of a baculovirus transfer
vector incorporating an anti-apoptotic vankyrin expression
cassette. Proteins were purified using immobilized metal affinity
chromatography. Solubility issues in the NS4, NS5a and NS5b
proteins were overcome using urea or guanidine based
solubilisation. Purified proteins were optimised in individual
ELISAs, and their performance assessed for the detection of
anti-HCV in both serum and dried
blood spot samples. Results from
the individual ELISAs were combined to give a multi analyte array
type profile. Performance for detection of anti-HCV in serum
samples was high, with a sensitivity of 91.6% while maintaining a
specificity of 100%. Performance with DBS samples was higher,
giving a sensitivity and specificity of 100%. This matched the
performance of the commercial Roche Elecsys® anti-HCV assay and
improved on the performance of the commercial Ortho anti-HCV assay
for screening of anti-HCV from DBS samples, while removing the need
for anti-HCV confirmation testing in the majority (93.5%) of
samples.
Advisors/Committee Members: VALLELY, PAMELA PJ, BORROW, RAYMOND R, Klapper, Paul, Vallely, Pamela, Borrow, Raymond.
Subjects/Keywords: Dried blood spot
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APA ·
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MLA ·
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APA (6th Edition):
Brown, B. S. (2020). Diagnosis of Hepatitis C Using Dried Blood
Spots. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326122
Chicago Manual of Style (16th Edition):
Brown, Benjamin Scott. “Diagnosis of Hepatitis C Using Dried Blood
Spots.” 2020. Doctoral Dissertation, University of Manchester. Accessed March 07, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326122.
MLA Handbook (7th Edition):
Brown, Benjamin Scott. “Diagnosis of Hepatitis C Using Dried Blood
Spots.” 2020. Web. 07 Mar 2021.
Vancouver:
Brown BS. Diagnosis of Hepatitis C Using Dried Blood
Spots. [Internet] [Doctoral dissertation]. University of Manchester; 2020. [cited 2021 Mar 07].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326122.
Council of Science Editors:
Brown BS. Diagnosis of Hepatitis C Using Dried Blood
Spots. [Doctoral Dissertation]. University of Manchester; 2020. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:326122
Rutgers University
29.
Rajeshirke, Shubham Narendra, 1995-.
A computational study of breath flow in an alcohol detection sensor.
Degree: MS, Mechanical and Aerospace Engineering, 2020, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/64933/
► Every year many accidents and deaths are caused related to drunk driving in the United States alone. Not only lives are lost but also public…
(more)
▼ Every year many accidents and deaths are caused related to drunk driving in the United States alone. Not only lives are lost but also public and private property destruction is caused. To tackle these ever-occurring problems, the (“DADSS”) DRIVER ALCOHOL DETECTION SYSTEM for SAFETY program was established. This program is responsible to tackle the problems faced due to drunk driving.
This program is directed at developing an alcohol detection system that is capable of detecting whether a driver is impaired by alcohol and take appropriate measures accordingly.
The research focuses on the design of the inlet for the sensor used in alcohol detection in a vehicle and the simulation of breath flow through the inlet designed to retrofit an actual car. This study is carried out to show how the sensor inlet design could be improved if needed. We study what is the effect of variation of flow rate, variation of inlet area, variation of inlet shape, and change in inclination of the inlet air on the senor inlet. In every variation considered for the study, all the other factors are kept constant.
Results are displayed with the images of flow over and in the sensor inlet. Velocity profiles and velocity contours are shown for all the simulations to grasp a better understanding of how these effects could be potentially used towards the advancement of the research in the future. We can use the conducted research results to further make necessary changes in the design of the sensors if deemed needed.
Advisors/Committee Members: Jaluria, Yogesh (chair), School of Graduate Studies.
Subjects/Keywords: Blood alcohol – Analysis
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APA (6th Edition):
Rajeshirke, Shubham Narendra, 1. (2020). A computational study of breath flow in an alcohol detection sensor. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/64933/
Chicago Manual of Style (16th Edition):
Rajeshirke, Shubham Narendra, 1995-. “A computational study of breath flow in an alcohol detection sensor.” 2020. Masters Thesis, Rutgers University. Accessed March 07, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/64933/.
MLA Handbook (7th Edition):
Rajeshirke, Shubham Narendra, 1995-. “A computational study of breath flow in an alcohol detection sensor.” 2020. Web. 07 Mar 2021.
Vancouver:
Rajeshirke, Shubham Narendra 1. A computational study of breath flow in an alcohol detection sensor. [Internet] [Masters thesis]. Rutgers University; 2020. [cited 2021 Mar 07].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/64933/.
Council of Science Editors:
Rajeshirke, Shubham Narendra 1. A computational study of breath flow in an alcohol detection sensor. [Masters Thesis]. Rutgers University; 2020. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/64933/
University of Manchester
30.
Brown, Benjamin.
Diagnosis of hepatitis C using dried blood spots.
Degree: PhD, 2020, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/diagnosis-of-hepatitis-c-using-dried-blood-spots(1a0a0e8e-5743-4bf6-98dd-81b84c6cec40).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823283
► Hepatitis C virus (HCV) is a major worldwide health issue, infecting approximately 71.1 million people worldwide, with 143 000 thought to be chronically infected in…
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▼ Hepatitis C virus (HCV) is a major worldwide health issue, infecting approximately 71.1 million people worldwide, with 143 000 thought to be chronically infected in England. The vast majority of these (92.1%) infections are found in injecting drug users. A major breakthrough in screening has been achieved in the past few years with the introduction of increased screening for HCV, specifically targeting the injecting drug user population. Dried blood spots were shown to be a suitable sample type to use in these circumstances, overcoming previous issues caused by poor venous access and limited availability of sufficiently trained phlebotomists and increasing testing in this population. Despite the improvements brought about through the use of this sample type several issues still remain including: - A large population of injecting drug users are still unaware of their hepatitis C infection. - Testing from dried blood spots uses commercial CE marked HCV serological assays, but these assays are not CE marked for use with dried blood spots. - Optimisation of commercial assays has increased the sensitivity achievable from dried blood spots to a high level (97-100%) this does not match that available from serum samples. Only an assay specifically designed for dried blood spot samples will be able to increase the sensitivity past what is currently achievable. - Reliable identification of acute HCV infection is not currently possible. The HCV Core, NS3, NS4, NS5a and NS5b proteins were produced using flashBAC™ ultra baculovirus expression system. Low protein yield in NS4, NS5a and NS5b protein production was overcome with the use of a baculovirus transfer vector incorporating an anti-apoptotic vankyrin expression cassette. Proteins were purified using immobilized metal affinity chromatography. Solubility issues in the NS4, NS5a and NS5b proteins were overcome using urea or guanidine based solubilisation. Purified proteins were optimised in individual ELISAs, and their performance assessed for the detection of anti-HCV in both serum and dried blood spot samples. Results from the individual ELISAs were combined to give a multi analyte array type profile. Performance for detection of anti-HCV in serum samples was high, with a sensitivity of 91.6% while maintaining a specificity of 100%. Performance with DBS samples was higher, giving a sensitivity and specificity of 100%. This matched the performance of the commercial Roche Elecsys® anti-HCV assay and improved on the performance of the commercial Ortho anti-HCV assay for screening of anti-HCV from DBS samples, while removing the need for anti-HCV confirmation testing in the majority (93.5%) of samples.
Subjects/Keywords: Dried blood spot
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APA (6th Edition):
Brown, B. (2020). Diagnosis of hepatitis C using dried blood spots. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/diagnosis-of-hepatitis-c-using-dried-blood-spots(1a0a0e8e-5743-4bf6-98dd-81b84c6cec40).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823283
Chicago Manual of Style (16th Edition):
Brown, Benjamin. “Diagnosis of hepatitis C using dried blood spots.” 2020. Doctoral Dissertation, University of Manchester. Accessed March 07, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/diagnosis-of-hepatitis-c-using-dried-blood-spots(1a0a0e8e-5743-4bf6-98dd-81b84c6cec40).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823283.
MLA Handbook (7th Edition):
Brown, Benjamin. “Diagnosis of hepatitis C using dried blood spots.” 2020. Web. 07 Mar 2021.
Vancouver:
Brown B. Diagnosis of hepatitis C using dried blood spots. [Internet] [Doctoral dissertation]. University of Manchester; 2020. [cited 2021 Mar 07].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/diagnosis-of-hepatitis-c-using-dried-blood-spots(1a0a0e8e-5743-4bf6-98dd-81b84c6cec40).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823283.
Council of Science Editors:
Brown B. Diagnosis of hepatitis C using dried blood spots. [Doctoral Dissertation]. University of Manchester; 2020. Available from: https://www.research.manchester.ac.uk/portal/en/theses/diagnosis-of-hepatitis-c-using-dried-blood-spots(1a0a0e8e-5743-4bf6-98dd-81b84c6cec40).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823283
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