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1. Miname, Márcio Hiroshi. Avaliação da aterosclerose subclínica coronariana e carotídea em portadores de hipercolesterolemia familiar: análise pela angiotomografia coronária, rigidez arterial e espessura íntima-média carotídea.

Degree: PhD, Cardiologia, 2010, University of São Paulo

A hipercolesterolemia familiar (HF) é uma doença autossômica dominante caracterizada por níveis elevados de LDL-c e doença arterial coronária (DAC) precoce. Existem evidências de maior prevalência de aterosclerose subclínica nesta população avaliada pelo escore de cálcio (CAC) e pela espessura íntima-média carotídea (EIMC). O objetivo do nosso estudo foi avaliar aterosclerose subclínica por meio da angiotomografia de coronárias em portadores de HF sem aterosclerose manifesta, correlacionando os achados com parâmetros clínicos, laboratoriais, rigidez aórtica e carotídea e com a EIMC. Incluímos 102 HFs, (45±13 anos, 36% homens, LDL-c 280±54mg/dL) e 35 controles (46±12 anos, 40% homens, LDL-c 103±18mg/dL). O grupo HF apresentava maior carga de placa aterosclerótica representado por: maior número de pacientes com placa (48% versus 14%, p=0,0005), maior número de pacientes com estenose luminal acima de 50% (19% versus 3%, p=0,015), maior número total de segmentos com placas (2,0±2,8 versus 0,4±1,3, p=0,0016), maior número de segmentos com placas calcificadas (0,8±1,54 versus 0,11±0,67, p= 0,0044) e maior escore de cálcio pelo método de Agatston (55±129, mediana:0 versus 38±140, mediana:0; p=0,0028). Houve correlação positiva no grupo HF do número total de segmentos com placa com: idade (r=0,41, p<0,0001), escore de risco de Framingham (r=0,25, p=0,012), colesterol total (r=0,36, p<0,0002), LDL-c (r=0,27, p=0,005), HDL-c (r=0,24, p=0,017), apolipoproteína B (r=0,3, p=0,0032) e escore de cálcio (r=0,93, p<0,0001). Além disso, houve correlação negativa com: variação sísto-diastólica carotídea (r=-0,23, p=0,028) e percentual de distensão carotídeo (r=-0,24, p=0,014). A análise multivariada de determinantes da presença de placa aterosclerótica, revelou que idade (OR=1,105, IC95%: 1,049-1,164, p<0,001) e colesterol total (OR=1,013, IC95%:1,001-1,025) foram as variáveis associadas com a presença da mesma. A única variável associada com presença de obstrução luminal acima de 50% foi o escore de cálcio coronário (OR=1,004; IC95%:1,001-1,008; p=0,014). Em relação a determinantes da composição de placa, na análise multivariada a presença de placa não calcificada esteve associada com o sexo masculino (OR:15,45; IC95%: 1,72-138,23, p=0,014), a placa mista com antecedente familiar de DAC precoce (OR=4,90; IC95%:1,32-18,21, p=0,018) e placa calcificada a menor chance com o sexo masculino (OR=0,21; IC95%: 0,05-0,84, p=0,027). Conclusões: Os pacientes portadores de HF apresentam maior carga de placa avaliada pela angiotomografia em comparação aos controles; idade e colesterol total associaram-se a presença de placas no grupo HF; o escore de cálcio associou-se a presença de estenose luminal acima de 50%.

Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by high LDL-c levels and premature coronary artery disease (CAD) onset. There is evidence of greater prevalence of subclinical atherosclerosis in this population evaluated by coronary calcium score (CCS) and carotid intima-media thickness (IMT). The aim of…

Advisors/Committee Members: Santos Filho, Raul Dias dos.

Subjects/Keywords: Angiotomografia coronária; Artérias/fisiopatologia; Arteries/physiopathology; Aterosclerose; Atherosclerosis; Carotid artery disease; Coronary angiotomography; Coronary artery disease; Doença da artéria coronariana; Doenças das artérias carótidas; Familial hypercholesterolemia; Hipercolesterolemia familiar

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Miname, M. H. (2010). Avaliação da aterosclerose subclínica coronariana e carotídea em portadores de hipercolesterolemia familiar: análise pela angiotomografia coronária, rigidez arterial e espessura íntima-média carotídea. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5131/tde-12012011-161846/ ;

Chicago Manual of Style (16th Edition):

Miname, Márcio Hiroshi. “Avaliação da aterosclerose subclínica coronariana e carotídea em portadores de hipercolesterolemia familiar: análise pela angiotomografia coronária, rigidez arterial e espessura íntima-média carotídea.” 2010. Doctoral Dissertation, University of São Paulo. Accessed September 18, 2020. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-12012011-161846/ ;.

MLA Handbook (7th Edition):

Miname, Márcio Hiroshi. “Avaliação da aterosclerose subclínica coronariana e carotídea em portadores de hipercolesterolemia familiar: análise pela angiotomografia coronária, rigidez arterial e espessura íntima-média carotídea.” 2010. Web. 18 Sep 2020.

Vancouver:

Miname MH. Avaliação da aterosclerose subclínica coronariana e carotídea em portadores de hipercolesterolemia familiar: análise pela angiotomografia coronária, rigidez arterial e espessura íntima-média carotídea. [Internet] [Doctoral dissertation]. University of São Paulo; 2010. [cited 2020 Sep 18]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5131/tde-12012011-161846/ ;.

Council of Science Editors:

Miname MH. Avaliação da aterosclerose subclínica coronariana e carotídea em portadores de hipercolesterolemia familiar: análise pela angiotomografia coronária, rigidez arterial e espessura íntima-média carotídea. [Doctoral Dissertation]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/5/5131/tde-12012011-161846/ ;


Universidade Estadual de Campinas

2. Molinari, Giovani José Dal Poggetto, 1980-. Roteiro de estudo na correção endovascular dos aneurismas de aorta abdominal através do software OsiriX = A uniform study through OsiriX software in preparation for endovascular aneurysm repair: A uniform study through OsiriX software in preparation for endovascular aneurysm repair.

Degree: 2016, Universidade Estadual de Campinas

Abstract: Despite patient and medical staff exposure to radiation in endovascular aneurysm repair, the benefits of this abdominal aortic aneurysm repair are justfied by minor recovery time and hospitalization, as well as an option for patients not elected to conventional open repair. To ensure its results, it requires precise deployment of the graft and in order to achieve accurate positioning, the anatomical and morphological aorta¿s characteristics assessment is mandatory. However, time of procedure and radiation doses can be substantial ¿ and its increase in number and complexity raises subsequent and additional risk to occupational radiation exposure. Meticulous study of the angiotomography during preparation for endovascular repair allows reduction of unnecessary radiation exposure and reduces consecutive image acquisition and contrast use (that may be related to renal overload in susceptible patients). Software that perform three dimensional reformatting of multislice tomographic images, allow's the study of the whole aorto-iliac axis and the perpendicular visualization of the renal arteries¿ origin, the proximal neck¿s correct length and adequate graft fixation and sealing can be foreseen. Aditionally, dose-irradiated distribution data manipulation allows to simulate an intraoperative fluoroscopy to predict catheter and the C-arm positioning. The closer to the tomographic reproduction is the radioscopic correction, the more careful is the visualization of the lowest renal artery¿s ostium and the better is the neck¿s exploitation for proximal fixing and sealing. Still, some studies have proposed strategies to optimize endovascular intervention to reduce contrast use and X-ray exposure. Although they might prove to be effective, they rely on use of additional specific and advanced equipment, available only in major centers. As an alternative to this expensive and restrict technology, it is presented a simpler technique through image manipulation on software OsiriX MD, aiming to reduce both exposures. A longitudinal prospective study, where 30 performed endovascular aneurysm repair were compared to a historic control group. The planning for endovascular aneurysm repair through a script-based guide upon gathering detailed computed tomography angiography images was elaborated by the author and distributed to the performing surgical team for appreciation, instruction and pre operatory judgment. Based upon the script, the C-arm gantry angle was specifically corrected in each case of endovascular aneurysm repair, for image optimization and aneurysm¿s neck visualization. Arteriography was performed under digital subtraction after catheters were positioned according to predicted level description in the referred guide. Statistical analysis were performed with a significance level of 5% (P value?0.05). There was a statistically significant relationship between the two studied periods and the variables: contrast volume (284.5 vs. 31.8 mL), operative time (207.5 vs. 140.4 min.) and blood loss (798.1 vs. 204.4 mL),… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Guillaumon, Ana Terezinha, 1951- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Ciências da Cirurgia (nameofprogram), Joviliano, Edwaldo Edner (committee member), Sobreira, Marcone Lima (committee member), Peres, Marco Antonio de Oliveira (committee member), Ataide, Elaine Cristina de (committee member).

Subjects/Keywords: Procedimentos endovasculares; Aneurisma da aorta abdominal - Cirurgia; Angiotomografia; Interface gráfica com o usuário (Sistemas de computação); Fluoroscopia; Endovascular procedures; Aortic aneurysm, Abdominal, Surgery; Computerized tomography angiography; Graphical user interfaces (Computer systems); Fluoroscopy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Molinari, Giovani José Dal Poggetto, 1. (2016). Roteiro de estudo na correção endovascular dos aneurismas de aorta abdominal através do software OsiriX = A uniform study through OsiriX software in preparation for endovascular aneurysm repair: A uniform study through OsiriX software in preparation for endovascular aneurysm repair. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/321066

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Molinari, Giovani José Dal Poggetto, 1980-. “Roteiro de estudo na correção endovascular dos aneurismas de aorta abdominal através do software OsiriX = A uniform study through OsiriX software in preparation for endovascular aneurysm repair: A uniform study through OsiriX software in preparation for endovascular aneurysm repair.” 2016. Thesis, Universidade Estadual de Campinas. Accessed September 18, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/321066.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Molinari, Giovani José Dal Poggetto, 1980-. “Roteiro de estudo na correção endovascular dos aneurismas de aorta abdominal através do software OsiriX = A uniform study through OsiriX software in preparation for endovascular aneurysm repair: A uniform study through OsiriX software in preparation for endovascular aneurysm repair.” 2016. Web. 18 Sep 2020.

Vancouver:

Molinari, Giovani José Dal Poggetto 1. Roteiro de estudo na correção endovascular dos aneurismas de aorta abdominal através do software OsiriX = A uniform study through OsiriX software in preparation for endovascular aneurysm repair: A uniform study through OsiriX software in preparation for endovascular aneurysm repair. [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2020 Sep 18]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/321066.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Molinari, Giovani José Dal Poggetto 1. Roteiro de estudo na correção endovascular dos aneurismas de aorta abdominal através do software OsiriX = A uniform study through OsiriX software in preparation for endovascular aneurysm repair: A uniform study through OsiriX software in preparation for endovascular aneurysm repair. [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/321066

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.