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University of Georgia
1.
Morgan, Stephen Paul.
Book DNA: validating how successful mystery literature is constructed.
Degree: MA, Journalism and Mass Communication, 2013, University of Georgia
URL: http://purl.galileo.usg.edu/uga_etd/morgan_stephen_p_201305_ma 
► This content analysis validates how writers construct commercially or critically successful literature in the mystery genre. The produced data and analysis seek to ground writers’…
(more)
▼ This content analysis validates how writers construct commercially or critically successful literature in the mystery genre. The produced data and analysis seek to ground writers’ creative intuitions by educating them on what has worked before, as well as helping delineate the upper limits of innovations on and deviations from genre conventions. Due to the high sales figures of the mystery genre, as well as a theoretical domain transfer when applying the methodology to other genres, this research will focus on the mystery genre. Though Uses and Gratifications theory would have provided ample foundation for the study, a more appropriate theoretical base came from the Narrative Paradigm, which condenses audience needs into two core concepts: Narrative Fidelity and Narrative Coherence.
Advisors/Committee Members: Leara Rhodes.
Subjects/Keywords: Thesis
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APA (6th Edition):
Morgan, S. P. (2013). Book DNA: validating how successful mystery literature is constructed. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/morgan_stephen_p_201305_ma
Chicago Manual of Style (16th Edition):
Morgan, Stephen Paul. “Book DNA: validating how successful mystery literature is constructed.” 2013. Masters Thesis, University of Georgia. Accessed February 18, 2020.
http://purl.galileo.usg.edu/uga_etd/morgan_stephen_p_201305_ma.
MLA Handbook (7th Edition):
Morgan, Stephen Paul. “Book DNA: validating how successful mystery literature is constructed.” 2013. Web. 18 Feb 2020.
Vancouver:
Morgan SP. Book DNA: validating how successful mystery literature is constructed. [Internet] [Masters thesis]. University of Georgia; 2013. [cited 2020 Feb 18].
Available from: http://purl.galileo.usg.edu/uga_etd/morgan_stephen_p_201305_ma.
Council of Science Editors:
Morgan SP. Book DNA: validating how successful mystery literature is constructed. [Masters Thesis]. University of Georgia; 2013. Available from: http://purl.galileo.usg.edu/uga_etd/morgan_stephen_p_201305_ma
University of Georgia
2.
Cummins, Shannon Elizabeth.
Diminuation of concentrative nucleoside transporter 1 (CNT1) activity in human ovarian cancer cells: subtype dependent gemcitabine response to exogenously expressed hCNT1.
Degree: BS, Biology, 2009, University of Georgia
URL: http://purl.galileo.usg.edu/uga_etd/cummins_shannon_e_200912_bs
► Human concentrative nucleoside transporter1 (hCNT1), a member of the solute carrier 28 family, is a high-affinity transporter of anti-cancer nucleoside drugs (e.g. gemcitabine). While hCNT1…
(more)
▼ Human concentrative nucleoside transporter1 (hCNT1), a member of the solute carrier 28 family, is a high-affinity transporter of anti-cancer nucleoside drugs (e.g. gemcitabine). While hCNT1 is implicated in sensitizing solid tumors to gemcitabine, its role in determining gemcitabine efficacy in human ovarian cancers remains unknown. Here we examined the functional expression of hCNT1 in normal and cancerous ovarian cells and compared its contributions towards gemcitabine efficacy in histological subtypes of ovarian cancer. RNA and protein analysis identified that unlike normal ovarian surface epithelial cells (IOSE80), which expressed high levels of hCNT1 at the cell surface, hCNT1 expressions were diminished in ovarian cancer cell lines. Consistently, 3H-gemcitabine transports in ovarian cancer cells were reduced by 3-10 fold compared with that of IOSE80 cells. Stable retroviral expression of hCNT1 in various ovarian cancer cell lines displayed variations in hCNT1 localizations, 3H-gemcitabine transports, and drug sensitivities. hCNT1-expressing endometroid cancer cells exhibited the highest sensitivity to gemcitabine treatment (~140 fold IC50 decrease). hCNT1-expressing serous ovarian cancer cells (OV90) displayed a moderate level of sensitivity (~25 fold IC50 decrease) that was ~2000-fold higher than that observed with clear cell carcinoma (CCC; ES-2 and TOV21G) and teratocarcinoma cells (PA-1). hCNT1 was not recruited to the cell surface in teratocarcinoma cells and was mistargeted to golgi in CCC cells. These data show that hCNT1 transportability is highly diminished in human ovarian cancers and the reintroduction of hCNT1 can selectively regain gemcitabine sensitivity in the endometroid and serous subtypes but not in the teratocarcinoma or CCC subtypes.
Advisors/Committee Members: Rajgopal Govindarajan.
Subjects/Keywords: Thesis
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APA (6th Edition):
Cummins, S. E. (2009). Diminuation of concentrative nucleoside transporter 1 (CNT1) activity in human ovarian cancer cells: subtype dependent gemcitabine response to exogenously expressed hCNT1. (Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/cummins_shannon_e_200912_bs
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cummins, Shannon Elizabeth. “Diminuation of concentrative nucleoside transporter 1 (CNT1) activity in human ovarian cancer cells: subtype dependent gemcitabine response to exogenously expressed hCNT1.” 2009. Thesis, University of Georgia. Accessed February 18, 2020.
http://purl.galileo.usg.edu/uga_etd/cummins_shannon_e_200912_bs.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cummins, Shannon Elizabeth. “Diminuation of concentrative nucleoside transporter 1 (CNT1) activity in human ovarian cancer cells: subtype dependent gemcitabine response to exogenously expressed hCNT1.” 2009. Web. 18 Feb 2020.
Vancouver:
Cummins SE. Diminuation of concentrative nucleoside transporter 1 (CNT1) activity in human ovarian cancer cells: subtype dependent gemcitabine response to exogenously expressed hCNT1. [Internet] [Thesis]. University of Georgia; 2009. [cited 2020 Feb 18].
Available from: http://purl.galileo.usg.edu/uga_etd/cummins_shannon_e_200912_bs.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cummins SE. Diminuation of concentrative nucleoside transporter 1 (CNT1) activity in human ovarian cancer cells: subtype dependent gemcitabine response to exogenously expressed hCNT1. [Thesis]. University of Georgia; 2009. Available from: http://purl.galileo.usg.edu/uga_etd/cummins_shannon_e_200912_bs
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Georgia
3.
Feinberg, Amy Marie.
Candidate false statement laws and the First Amendment: an analysis of constitutional principles.
Degree: MA, Mass Communication, 2015, University of Georgia
URL: http://purl.galileo.usg.edu/uga_etd/feinberg_amy_m_201505_ma
► Since the early 1900s, states have enacted laws to prohibit false statements about candidates in elections. These laws have in some states been overturned more…
(more)
▼ Since the early 1900s, states have enacted laws to prohibit false statements about candidates in elections. These laws have in some states been overturned more than once, as state assemblies often choose to pass slightly modified versions of these laws after unfavorable judicial outcomes. In the wake of the 2014 Supreme Court decision in Susan B. Anthony List v. Driehaus, this
thesis examines why states continue to seek to adopt statutes to criminalize false statements about political candidates. This work identifies three reasons prompting the actions of most states: a desire to protect candidates, to protect voters, and to protect the elections process itself, but ultimately concludes that these statutes, while perhaps well-intentioned, are ultimately unlikely to be constitutional.
Advisors/Committee Members: William Lee.
Subjects/Keywords: Thesis
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APA (6th Edition):
Feinberg, A. M. (2015). Candidate false statement laws and the First Amendment: an analysis of constitutional principles. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/feinberg_amy_m_201505_ma
Chicago Manual of Style (16th Edition):
Feinberg, Amy Marie. “Candidate false statement laws and the First Amendment: an analysis of constitutional principles.” 2015. Masters Thesis, University of Georgia. Accessed February 18, 2020.
http://purl.galileo.usg.edu/uga_etd/feinberg_amy_m_201505_ma.
MLA Handbook (7th Edition):
Feinberg, Amy Marie. “Candidate false statement laws and the First Amendment: an analysis of constitutional principles.” 2015. Web. 18 Feb 2020.
Vancouver:
Feinberg AM. Candidate false statement laws and the First Amendment: an analysis of constitutional principles. [Internet] [Masters thesis]. University of Georgia; 2015. [cited 2020 Feb 18].
Available from: http://purl.galileo.usg.edu/uga_etd/feinberg_amy_m_201505_ma.
Council of Science Editors:
Feinberg AM. Candidate false statement laws and the First Amendment: an analysis of constitutional principles. [Masters Thesis]. University of Georgia; 2015. Available from: http://purl.galileo.usg.edu/uga_etd/feinberg_amy_m_201505_ma
University of Southern California
4.
Starr, Jason.
Jason Starr's thesis.
Degree: MFA, Fine Arts, 2009, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/537858/rec/3682
► The relationship between an artwork and the language used to describe its meaning or justify its importance is tenuous at best. Interpretation and translation transcribe…
(more)
▼ The relationship between an artwork and the language
used to describe its meaning or justify its importance is tenuous
at best. Interpretation and translation transcribe information in
an endless mutation. This written work is an impaired attempt to
express oneself in words. As any language will either not suffice
or will provide only an alternative version of what was meant, here
the core concerns of a particular body of artwork have been written
out in a foreign language. – A thought is initiated and it is
translated into language. A thought is initiated and it is
translated into an artwork. A work of art is made and it is
translated into words. The human mind exhibits the capacity to
direct itself at an outside world, to express itself and to
communicate, but the problem of translating what is internal lies
at the core of existence. The resulting text, originally attempted
in Spanish, has been translated into English for your further
interpretation.
Advisors/Committee Members: Stark, Frances (Committee Chair), [illegible] (Committee Member), [illegible] (Committee Member).
Subjects/Keywords: thesis
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APA (6th Edition):
Starr, J. (2009). Jason Starr's thesis. (Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/537858/rec/3682
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Starr, Jason. “Jason Starr's thesis.” 2009. Thesis, University of Southern California. Accessed February 18, 2020.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/537858/rec/3682.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Starr, Jason. “Jason Starr's thesis.” 2009. Web. 18 Feb 2020.
Vancouver:
Starr J. Jason Starr's thesis. [Internet] [Thesis]. University of Southern California; 2009. [cited 2020 Feb 18].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/537858/rec/3682.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Starr J. Jason Starr's thesis. [Thesis]. University of Southern California; 2009. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/537858/rec/3682
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Li, Hongxiu.
Three Essays on the Economics of Innovation as Adaptation to Climate Change.
Degree: 2017, University of Waterloo
URL: http://hdl.handle.net/10012/12696
► This thesis consists of three chapters on technological innovation as adaptation to climate change. The first chapter adopts a non-cooperative game theory model to investigate…
(more)
▼ This thesis consists of three chapters on technological innovation as adaptation to climate change.
The first chapter adopts a non-cooperative game theory model to investigate the relationship between adaptation technology and the formation of emission-reducing International Environmental Agreements (IEAs) on climate change. The main contribution to the literature consists of considering countries that are heterogeneous with respect to the benefits and costs of both mitigation of emissions and adaptation. While differences in climate vulnerability are a deterrent for cooperation, this chapter shows that increasing the effectiveness of adaptation in highly vulnerable countries can foster an IEA. Both free-riding on climate change mitigation efforts, and free-riding on adaptation technology among members of an IEA can be reduced by the transfer of adaptation technology within the IEA. A numerical example with parameters estimated from climate change data is employed to simulate stable coalitions and demonstrate how the transfer of adaptation technology reduces free-riding on an IEA.
The second chapter examines the determinants of adaptive innovation aimed at reducing the impact of natural disasters, which are expected to intensify with climate change. Starting from a conceptual model combining perceived risk theory with innovators' profit motive, this study investigates the salience of innovation induced by natural disasters, using a unique dataset that includes related U.S. patent data, and flood, drought, and earthquake damage data for the years 1977 to 2005. To address the potential endogeneity of disaster damage, the control function approach is employed with instrumental variables constructed from disaster intensity measurements. The results show that impact-reducing innovations at the state level respond to national disaster damages in the U.S. In general, the impact of natural disasters is not localized to a state – that is, disaster damage in a state also stimulates innovations in more-distant states. This is in contrast with comparable existing cross-country evidence. The findings in this paper highlight a policy role for the federal government in more effectively spurring impact-reducing innovations nationwide.
With the pressure of economic growth and the impact of climate change, water issues such as water shortage and pollution have substantial impacts on welfare and sustainability.
Taking a view of innovation as adaptation to intensified water threats, the third chapter explores the impact of federal and state level regulatory changes with respect to drinking water quality, water pollution and water quantity in the U.S. on the level of relevant technological innovation. Based on a detailed review of relevant legislative acts, a unique dataset covering major amendments and additions to regulated contaminants lists is constructed to capture the changes of water governance in the U.S. in the past 30 years. In addition, technological patents pertaining to water quality and quantity are identified…
Subjects/Keywords: Thesis
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APA ·
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APA (6th Edition):
Li, H. (2017). Three Essays on the Economics of Innovation as Adaptation to Climate Change. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/12696
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Li, Hongxiu. “Three Essays on the Economics of Innovation as Adaptation to Climate Change.” 2017. Thesis, University of Waterloo. Accessed February 18, 2020.
http://hdl.handle.net/10012/12696.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Li, Hongxiu. “Three Essays on the Economics of Innovation as Adaptation to Climate Change.” 2017. Web. 18 Feb 2020.
Vancouver:
Li H. Three Essays on the Economics of Innovation as Adaptation to Climate Change. [Internet] [Thesis]. University of Waterloo; 2017. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10012/12696.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Li H. Three Essays on the Economics of Innovation as Adaptation to Climate Change. [Thesis]. University of Waterloo; 2017. Available from: http://hdl.handle.net/10012/12696
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Waterloo
6.
Charlebois, Gemma.
Microcystin and Microcystis Destruction by Ozone in Drinking Water Treatment: Constraints and Effects.
Degree: 2016, University of Waterloo
URL: http://hdl.handle.net/10012/10583
► Appropriate and effective drinking water treatment is critical to the protection of public health. Toxic cyanobacterial blooms are a globally increasing drinking water source quality-associated…
(more)
▼ Appropriate and effective drinking water treatment is critical to the protection of public health. Toxic cyanobacterial blooms are a globally increasing drinking water source quality-associated health risk as even very low (>1.5 parts per billion (ppb) or micrograms per litre (µg/L)) concentrations of the cyanobacteria-produced toxin microcystin can be unsafe to drink. Increased pressures on freshwater supplies as well as climate change associated factors such as alternating periods of drought and intense storms and increasing water temperature cause more nutrient runoff into water supplies and create favourable conditions for the growth of cyanobacteria.
Ozone is generally understood to effectively destroy many toxins during drinking water treatment. Its efficacy, however, can be adversely impacted by the presence of natural organic matter, often measured as dissolved organic carbon (DOC). The conditions that create favourable growth conditions for cyanobacteria, can also increase the concentrations of DOC in the source water of a drinking water treatment facility.
The objectives of this research were to determine whether ozone is an effective cyanobacterial toxin elimination technology at the conditions studied; specifically in the presence of high DOC (~10 mg/L), to determine the efficacy of ozone in the destruction of intercellular (within cells) toxin vs. extracellular (within water matrix) toxin, and to determine the extent of cell destruction by ozone.
Bench-scale experiments were conducted. Both extracted toxin and cyanobacterial cells were added to coagulated/flocculated/clarified water collected from the Mannheim Water Treatment Plant in Kitchener, Ontario. Microcystin concentrations were measured by the ELISA method and by liquid chromatography-mass spectroscopy-mass spectroscopy (LC-MS-MS).
This investigation confirmed that ozone can destroy extracellular microcystin-LR to below 1.5 µg/L (ppb) at ozone residuals above 0.3 mg O3/L when the aqueous DOC concentration was below 5 mg/L. The relationship between required ozone residual to achieve adequate extracellular toxin destruction and DOC concentration in the water matrix was quantitatively described. Notably, when Microcystis aeruginosa cells were present, an amount equivalent to less than 50% of the concentration of extracellular microcystin-LR was destroyed by ozone. This demonstrates that significant oxidative capacity is required to lyse the cells before ozone can destroy intercellular toxin. The novel contribution of this work is that this relationship was 1) demonstrated through using toxin in extracted and cellular forms and 2) maintained when all other critical operational factors (i.e., ozone residual, DOC concentration, water matrix) were the same. These results underscore the need to reassess operational requirements for ozonation for the treatment of cyanobacterial toxins when intact cells are present as opposed to extracellular toxin, which is used in most performance assessments.
Notably, as the aqueous DOC concentration…
Subjects/Keywords: thesis
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APA ·
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APA (6th Edition):
Charlebois, G. (2016). Microcystin and Microcystis Destruction by Ozone in Drinking Water Treatment: Constraints and Effects. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/10583
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Charlebois, Gemma. “Microcystin and Microcystis Destruction by Ozone in Drinking Water Treatment: Constraints and Effects.” 2016. Thesis, University of Waterloo. Accessed February 18, 2020.
http://hdl.handle.net/10012/10583.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Charlebois, Gemma. “Microcystin and Microcystis Destruction by Ozone in Drinking Water Treatment: Constraints and Effects.” 2016. Web. 18 Feb 2020.
Vancouver:
Charlebois G. Microcystin and Microcystis Destruction by Ozone in Drinking Water Treatment: Constraints and Effects. [Internet] [Thesis]. University of Waterloo; 2016. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10012/10583.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Charlebois G. Microcystin and Microcystis Destruction by Ozone in Drinking Water Treatment: Constraints and Effects. [Thesis]. University of Waterloo; 2016. Available from: http://hdl.handle.net/10012/10583
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
7.
Ye, Qiang.
Adaptive Medium Access Control for Internet-of-Things Enabled Mobile Ad Hoc Networks.
Degree: 2016, University of Waterloo
URL: http://hdl.handle.net/10012/10927
► An Internet-of-Things (IoT) enabled mobile ad hoc network (MANET) is a self organized distributed wireless network, in which nodes can randomly move making the network…
(more)
▼ An Internet-of-Things (IoT) enabled mobile ad hoc network (MANET) is a self organized distributed wireless network, in which nodes can randomly move making the network traffic load vary with time. A medium access control (MAC) protocol, as a most important mechanism of radio resource management, is required in MANETs to coordinate nodes’ access to the wireless channel in a distributed way to satisfy their quality of service (QoS) requirements. However, the distinctive characteristics of IoT-enabled MANETs, i.e., distributed network operation, varying network traffic load, heterogeneous QoS demands,
and increased interference level with a large number of nodes and extended communication distances, pose technical challenges on MAC. An efficient MAC solution should achieve consistently maximal QoS performance by adapting to the network traffic load variations, and be scalable to an increasing number of nodes in a multi-hop communication environment.
In this thesis, we develop comprehensive adaptive MAC solutions for an IoT-enabled MANET with the consideration of different network characteristics.
First, an adaptive MAC solution is proposed for a fully-connected network, supporting homogeneous best-effort data traffic. Based on the detection of current network traffic load condition, nodes can make a switching decision between IEEE 802.11 distributed coordination function (DCF) and dynamic time division multiple access (D-TDMA), when the network traffic load reaches a threshold, referred to as MAC switching point. The adaptive MAC solution determines the MAC switching point in an analytically tractable way to achieve consistently high network performance by adapting to the varying network traffic load.
Second, when heterogeneous services are supported in the network, we propose an adaptive hybrid MAC scheme, in which a hybrid superframe structure is designed to accommodate the channel access from delay-sensitive voice traffic using time division multiple access (TDMA) and from best-effort data traffic using truncated carrier sense multiple access with collision avoidance (T-CSMA/CA). According to instantaneous voice and data traffic load conditions, the MAC exploits voice traffic multiplexing to increase the voice capacity by adaptively allocating TDMA time slots to active voice nodes, and maximizes
the aggregate data throughput by adjusting the optimal contention window size for each data node.
Lastly, we develop a scalable token-based adaptive MAC scheme for a two-hop MANET with an increasing number of nodes. In the network, nodes are partitioned into different one-hop node groups, and a TDMA-based superframe structure is proposed to allocate different TDMA time durations to different node groups to overcome the hidden terminal problem. A probabilistic token passing scheme is adopted for packet transmissions within different node groups, forming different token rings. An average end-to-end delay optimization framework is established to derive the set of optimal MAC parameters for
a varying network load…
Subjects/Keywords: Thesis
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APA ·
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Manager
APA (6th Edition):
Ye, Q. (2016). Adaptive Medium Access Control for Internet-of-Things Enabled Mobile Ad Hoc Networks. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/10927
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ye, Qiang. “Adaptive Medium Access Control for Internet-of-Things Enabled Mobile Ad Hoc Networks.” 2016. Thesis, University of Waterloo. Accessed February 18, 2020.
http://hdl.handle.net/10012/10927.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ye, Qiang. “Adaptive Medium Access Control for Internet-of-Things Enabled Mobile Ad Hoc Networks.” 2016. Web. 18 Feb 2020.
Vancouver:
Ye Q. Adaptive Medium Access Control for Internet-of-Things Enabled Mobile Ad Hoc Networks. [Internet] [Thesis]. University of Waterloo; 2016. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10012/10927.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ye Q. Adaptive Medium Access Control for Internet-of-Things Enabled Mobile Ad Hoc Networks. [Thesis]. University of Waterloo; 2016. Available from: http://hdl.handle.net/10012/10927
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Waterloo
8.
Mirahmadi Shalamzari, Akram.
Robust Multi-Class Multi-Period Scheduling of MRI Services with Wait Time Targets.
Degree: 2018, University of Waterloo
URL: http://hdl.handle.net/10012/12943
► In recent years, long wait times for healthcare services have become a challenge in most healthcare delivery systems in Canada. This issue becomes even more…
(more)
▼ In recent years, long wait times for healthcare services have become a challenge in most healthcare delivery systems in Canada. This issue becomes even more important when there are priorities in patients' treatment which means some of the patients need emergency treatment, while others can wait longer. One example of excessively long wait times in Canada is the MRI scans. These wait times are partially due to limited capacity and increased demand, but also due to sub-optimal scheduling policies. Patients are typically prioritized by the referring physician based on their health condition, and there is a wait time target for each priority level. The difficulty of scheduling increases due to uncertainty in patients' arrivals and service times. In this thesis, we develop a multi-priority robust optimization (RO) method to schedule patients for MRI services over a multi-period finite horizon. First, we present a deterministic mixed integer programming model which considers patient priorities, MRI capacity, and wait time targets for each priority level. We then investigate robust counterparts of the model by considering uncertainty in patients' arrivals and employing the notion of the budget of uncertainty. Finally, we apply the proposed robust model to a set of numerical examples and compare the results with those of the non-robust method. Moreover, sensitivity analysis is performed over capacity, penalty cost, service level, and budget of uncertainty. Our results demonstrate that the proposed robust approach provides solutions with higher service levels for each priority, and lower patients' wait time in realistic problem instances. The analysis also provides some insights on expanding capacity and choosing the budget of uncertainty as a trade-off between performance and conservatism.
Subjects/Keywords: Thesis
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APA (6th Edition):
Mirahmadi Shalamzari, A. (2018). Robust Multi-Class Multi-Period Scheduling of MRI Services with Wait Time Targets. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/12943
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mirahmadi Shalamzari, Akram. “Robust Multi-Class Multi-Period Scheduling of MRI Services with Wait Time Targets.” 2018. Thesis, University of Waterloo. Accessed February 18, 2020.
http://hdl.handle.net/10012/12943.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mirahmadi Shalamzari, Akram. “Robust Multi-Class Multi-Period Scheduling of MRI Services with Wait Time Targets.” 2018. Web. 18 Feb 2020.
Vancouver:
Mirahmadi Shalamzari A. Robust Multi-Class Multi-Period Scheduling of MRI Services with Wait Time Targets. [Internet] [Thesis]. University of Waterloo; 2018. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10012/12943.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mirahmadi Shalamzari A. Robust Multi-Class Multi-Period Scheduling of MRI Services with Wait Time Targets. [Thesis]. University of Waterloo; 2018. Available from: http://hdl.handle.net/10012/12943
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Waterloo
9.
Batmaz, Rasim.
Advanced Silicon Anode Architectures for High Energy Density Lithium-ion Batteries.
Degree: 2018, University of Waterloo
URL: http://hdl.handle.net/10012/13759
► The pressing environmental issues and the continuous increase in energy demand have drawn tremendous attention to the development of advanced electrochemical energy storage systems (EESS).…
(more)
▼ The pressing environmental issues and the continuous increase in energy demand have drawn tremendous attention to the development of advanced electrochemical energy storage systems (EESS). Lithium-ion batteries are currently the most developed EESS; however, they are insufficient to meet the requirements of energy intensive applications such as electric vehicles. This stems from the intrinsic limitations of commercial cathode and anode materials. Therefore, their electrochemical properties should be either improved by applying new fabrication techniques or replaced with new generation materials to increase their energy density, power density and stability.
Silicon is a promising candidate as a new generation anode material due to its enormous theoretical lithium storage capacity. However, silicon faces some technological hurdles such as poor cycle stability and rate capability. This stems from its intrinsic low electrical conductivity, severe volume change upon reaction with lithium, leading to loss of electrode integrity and formation of an unstable solid electrolyte interphase. In an attempt to address these problems, the proposed research projects have been embodied in this thesis. The main focus of these projects includes: enhancing electronic conductivity, forming stable electrolyte interphase and preventing electrode structural failure. To achieve these goals, novel silicon-carbon composite materials in which the silicon particles were hosted by nano-architectured carbon scaffolds were prepared to improve the electronic conductivity and help form a stable electrolyte interphase. Furthermore, to prevent electrode structure failure, the electrodes prepared from these silicon-carbon composite materials were subjected to thermal treatment to alter the electrode architecture by tuning the chemical structure of the binder.
In Chapter 4, an advanced silicon electrode was developed by using commercially available silicon nanoparticles (SiNPs) as the anode material and sulfur-doped graphene (SG) as a carbon support. The electrode slurry was prepared by mixing these components with polyacrylonitrile (PAN) binder and then applied to the current collector. After the electrodes were dried, a thermal treatment was applied to reconstruct the architecture of the electrodes. In this new electrode architecture, PAN polymer is turned into an aromatic structure (cPAN) with 6-membered rings hosting the nitrogen atoms in pyridinic position. Thus, after the treatment, SiNPs are surrounded by the 3D conductive hierarchical architecture of SG sheets and the aromatic structure of cPAN. It was found that the silicon atoms on the nanoparticle surfaces anchor to and covalently interact with the sulfur and nitrogen atoms of this carbonaceous nanoarchitecture. This prevents the agglomeration of silicon particles, maintains the electrode integrity and stabilizes the solid electrolyte interphase leading to a superior reversible capacity of over 1000 mAh g-1 for 2275 cycles at 2.0 A g-1. The excellent performance combined with the simple,…
Subjects/Keywords: Thesis
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APA (6th Edition):
Batmaz, R. (2018). Advanced Silicon Anode Architectures for High Energy Density Lithium-ion Batteries. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/13759
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Batmaz, Rasim. “Advanced Silicon Anode Architectures for High Energy Density Lithium-ion Batteries.” 2018. Thesis, University of Waterloo. Accessed February 18, 2020.
http://hdl.handle.net/10012/13759.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Batmaz, Rasim. “Advanced Silicon Anode Architectures for High Energy Density Lithium-ion Batteries.” 2018. Web. 18 Feb 2020.
Vancouver:
Batmaz R. Advanced Silicon Anode Architectures for High Energy Density Lithium-ion Batteries. [Internet] [Thesis]. University of Waterloo; 2018. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10012/13759.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Batmaz R. Advanced Silicon Anode Architectures for High Energy Density Lithium-ion Batteries. [Thesis]. University of Waterloo; 2018. Available from: http://hdl.handle.net/10012/13759
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Guelph
10.
Deyman, Kristen.
Impact of 1-Methylcyclopropene and Elevated CO2 on Polyamine and γ-Aminobutyrate Levels in ‘Empire’ Apple Fruit
.
Degree: 2014, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8467
► The hypothesis tested was that 1-methylcyclopropene, an ethylene antagonist, and elevated CO2 enhance the levels of polyamines and γ-aminobutyrate in ‘Empire’ apple (Malus domestica Borkh.)…
(more)
▼ The hypothesis tested was that 1-methylcyclopropene, an ethylene antagonist, and elevated CO2 enhance the levels of polyamines and γ-aminobutyrate in ‘Empire’ apple (Malus domestica Borkh.) fruit during controlled atmosphere storage. A 46-week experiment was conducted using a split-plot design with four treatment replicates and 3◦C, 2.5 kPa O2, and 0.03 or 2.5 kPa CO2 with or without 1 μL L−1 1-methylcyclopropene. The response of individual polyamines suggested that conversion of putrescine into higher polyamines and interconversion of free and conjugated forms was altered, rather than availability of S-adenosylmethionine. The stimulation of glutamate decarboxylase activity and inhibition of 4–aminobutyrate catabolism, rather than a contribution of polyamines, could account for the linear accumulation of γ-aminobutyrate over time. Results of untreated fruit at 2.5 kPa CO2 might differ from those found with frozen samples from a 2009 study using 5 kPa CO2, and this could be associated with the incidence of physiological injury.
Advisors/Committee Members: Shelp, Barry (advisor), Bozzo, Gale (advisor).
Subjects/Keywords: Thesis
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APA (6th Edition):
Deyman, K. (2014). Impact of 1-Methylcyclopropene and Elevated CO2 on Polyamine and γ-Aminobutyrate Levels in ‘Empire’ Apple Fruit
. (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8467
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Deyman, Kristen. “Impact of 1-Methylcyclopropene and Elevated CO2 on Polyamine and γ-Aminobutyrate Levels in ‘Empire’ Apple Fruit
.” 2014. Thesis, University of Guelph. Accessed February 18, 2020.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8467.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Deyman, Kristen. “Impact of 1-Methylcyclopropene and Elevated CO2 on Polyamine and γ-Aminobutyrate Levels in ‘Empire’ Apple Fruit
.” 2014. Web. 18 Feb 2020.
Vancouver:
Deyman K. Impact of 1-Methylcyclopropene and Elevated CO2 on Polyamine and γ-Aminobutyrate Levels in ‘Empire’ Apple Fruit
. [Internet] [Thesis]. University of Guelph; 2014. [cited 2020 Feb 18].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8467.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Deyman K. Impact of 1-Methylcyclopropene and Elevated CO2 on Polyamine and γ-Aminobutyrate Levels in ‘Empire’ Apple Fruit
. [Thesis]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8467
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
11.
Rafiei, Sepide.
Application of Distributed Generation Sources for Micro-Grid Power Quality Enhancement
.
Degree: Electrical and Computer Engineering, 2014, Queens University
URL: http://hdl.handle.net/1974/8611
► In conventional power generation systems, large centralized plants operating on fossil fuel mainly generate the electric power. The generated electricity has to travel through the…
(more)
▼ In conventional power generation systems, large centralized plants operating on fossil fuel mainly generate the electric power. The generated electricity has to travel through the long transmission and distribution lines to be delivered to the end users. In addition to being costly, this structure yields poor reliability and low efficiency. On the other hand, serious concerns have been raised about the shortage of fossil fuels, global warming, and energy security. As a result, the power systems are moving toward more distributed structures based on renewable energy resources.
During the last decade, the concept of small-scale energy resources distributed over the grid has gained a considerable interest. This concept is often called distributed generation (DG). DG systems are mainly using renewable energy sources as their prime movers. Renewable energy sources (including biomass, wind, solar, hydropower, and geothermal) can provide clean, efficient, reliable and adequate energy supply while making modern energy services accessible and affordable.
However, despite the substantial benefits of distributed generation, the application of an individual DG system can cause as many problems as it may solve. To avoid such problems and to realize the emerging potential of distributed generation, a system approach has been taken, in which generation and loads are considered as a subsystem called “micro-grid”.
One important issue in the existing power network is the capability of renewable energy sources to increase the power quality of the micro-grid. One aspect of this feature is harmonic compensation using distributed resources.
In this thesis an adoptive notch filter (ANF) is employed in the control system of a distributed generation (DG) system for harmonic compensation. It is shown that the performance of the system is highly improved using the adoptive notch filter.
Subjects/Keywords: THESIS
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APA (6th Edition):
Rafiei, S. (2014). Application of Distributed Generation Sources for Micro-Grid Power Quality Enhancement
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8611
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rafiei, Sepide. “Application of Distributed Generation Sources for Micro-Grid Power Quality Enhancement
.” 2014. Thesis, Queens University. Accessed February 18, 2020.
http://hdl.handle.net/1974/8611.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rafiei, Sepide. “Application of Distributed Generation Sources for Micro-Grid Power Quality Enhancement
.” 2014. Web. 18 Feb 2020.
Vancouver:
Rafiei S. Application of Distributed Generation Sources for Micro-Grid Power Quality Enhancement
. [Internet] [Thesis]. Queens University; 2014. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/1974/8611.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rafiei S. Application of Distributed Generation Sources for Micro-Grid Power Quality Enhancement
. [Thesis]. Queens University; 2014. Available from: http://hdl.handle.net/1974/8611
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Leicester
12.
Al Aridhee, Hasanain Y. M.
The role of properdin in the pathogenesis of murine systemic lupus erythematosus.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10330031.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794043
► In systemic lupus erythematosus (SLE), complement-activating immune complexes (ICs) are central to the immunopathogenesis of disease. Their deposition in kidney initiates an inflammatory response resulting…
(more)
▼ In systemic lupus erythematosus (SLE), complement-activating immune complexes (ICs) are central to the immunopathogenesis of disease. Their deposition in kidney initiates an inflammatory response resulting in glomerulonephritis. Properdin is the only known positive regulator of complement activation, but its role in SLE disease severity has not been studied yet. Properdin-deficient mice were crossed with MRL/lpr mice on C57Bl/6 background. MRL/lpr mice develop lupus-like disease spontaneously. We derived properdin wildtype, properdin deficient, and properdin heterozygous MRL/lpr mice. Compared to MRL/lpr properdin wildtype mice, MRL/lpr properdin-deficient mice developed significantly less severe disease, had lower serum anti-DNA antibody titre, reduced complement activation, less serum pro-inflammatory cytokines and showed less splenic surface expression of CR2 on B220 positive cells. Parallel analysis of properdin heterozygous MRL/lpr mice revealed a gene dose effect in some measures. There was less serum creatinine in MRL/lpr properdin-deficient mice and colocalising activated C3 fragments and immunoglobulins (ICs) in the mesangium, and less SMA-α and nephrin expression in MRL/lpr properdin-deficient mice compared to MRL/lpr properdin wildtype mice. These findings demonstrate that properdin plays a significant role in the severity of lupus and involvement of kidney in MRL/lpr mice. Because MRL/lpr properdin deficient mice had lower levels of anti-DNA Abs, inflammatory mediators and marker of renal impairment, the study implies that properdin could constitute a novel therapy target.
Subjects/Keywords: Thesis
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APA (6th Edition):
Al Aridhee, H. Y. M. (2019). The role of properdin in the pathogenesis of murine systemic lupus erythematosus. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10330031.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794043
Chicago Manual of Style (16th Edition):
Al Aridhee, Hasanain Y M. “The role of properdin in the pathogenesis of murine systemic lupus erythematosus.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10330031.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794043.
MLA Handbook (7th Edition):
Al Aridhee, Hasanain Y M. “The role of properdin in the pathogenesis of murine systemic lupus erythematosus.” 2019. Web. 18 Feb 2020.
Vancouver:
Al Aridhee HYM. The role of properdin in the pathogenesis of murine systemic lupus erythematosus. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10330031.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794043.
Council of Science Editors:
Al Aridhee HYM. The role of properdin in the pathogenesis of murine systemic lupus erythematosus. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10330031.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794043
University of Leicester
13.
Siverns, Kate.
'If only I could have said, if only somebody was listening' : mothers' experiences of placing their child into care in the context of trauma.
Degree: Thesis (D.Clin.Psy.), 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10305275.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794065
► Systematic Literature Review: Eleven papers exploring the experiences of parenting in the context of former childhood trauma were subjected to an interpretive meta-synthesis. Three themes…
(more)
▼ Systematic Literature Review: Eleven papers exploring the experiences of parenting in the context of former childhood trauma were subjected to an interpretive meta-synthesis. Three themes were generated. Forming a parental identity through the lens of trauma related to the interpretation of all parenting experiences, especially challenges, in terms of the effects of childhood abuse. Protecting against perceived threat related to many parents fearing they would be unable to protect their children, and themselves, from harm. The need for safe support was concerned with how parents often felt they needed support but experienced this as unsafe. Results highlighted how professionals should recognize ambivalence as understandable in the context of lived experience and should seek to avoid pathologizing parental difficulties by normalising difficult emotional reactions. Research Paper: Interpretative Phenomenological Analysis was used to explore the sense-making of three mothers with trauma histories who had made, or come to agree with, the decision for their child to be placed into care. Three superordinate themes were presented: A fractured sense of motherhood highlighted the struggle with mothering identities in line with feelings of disconnection and separation; 'I wish I could turn back the clocks': Living with feelings of failure and shame illuminated the underlying feelings of guilt and shame associated with perceived failings; 'Less than a person': Becoming nothing and no-one' alluded to the mothers' experiences of isolation and disempowerment, which led to feeling devalued and dehumanised. Themes were discussed in relation to existing theory and literature and highlighted the importance of acknowledging the role of loss and grief as well as the use of therapeutic interventions which are sensitive to the operation of power.
Subjects/Keywords: Thesis
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APA ·
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Export
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Manager
APA (6th Edition):
Siverns, K. (2019). 'If only I could have said, if only somebody was listening' : mothers' experiences of placing their child into care in the context of trauma. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10305275.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794065
Chicago Manual of Style (16th Edition):
Siverns, Kate. “'If only I could have said, if only somebody was listening' : mothers' experiences of placing their child into care in the context of trauma.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10305275.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794065.
MLA Handbook (7th Edition):
Siverns, Kate. “'If only I could have said, if only somebody was listening' : mothers' experiences of placing their child into care in the context of trauma.” 2019. Web. 18 Feb 2020.
Vancouver:
Siverns K. 'If only I could have said, if only somebody was listening' : mothers' experiences of placing their child into care in the context of trauma. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10305275.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794065.
Council of Science Editors:
Siverns K. 'If only I could have said, if only somebody was listening' : mothers' experiences of placing their child into care in the context of trauma. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10305275.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794065
University of Leicester
14.
Cusack, Paul L.
The mad road : a creative exploration of Irish diasporic experience.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.11335904.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793998
► The thesis is in two parts. The first part is a collection of short stories on Irish Diaspora − The Mad Road. There is, I…
(more)
▼ The thesis is in two parts. The first part is a collection of short stories on Irish Diaspora − The Mad Road. There is, I believe, a distinct lack of short fiction about Irish lives lived in England, and I felt this gap needed addressing. These stories engage with the Irish community and the nullifying grind of work. They examine the social pressures of diasporic existence experienced in England and Ireland. The collection is written from a second generational Irish working-class perspective and the stories tackle urban realties in a dark-realist way. The stories deal with issues including emigration, derelict life-style, alcoholism, loneliness and corruption. Because of my lifelong immersion in Irish culture, both in Ireland and Leicester, I feel uniquely placed to capture hidden aspects of Irish expatriate experience. The Mad Road is accompanied by an extended reflective analysis where I argue that critical theory and creative writing can inform each other. My dual perspective as both a writer and volunteer with The Emerald Centre has been of fundamental importance to my creative process. I discuss some of the interactions that I have experienced volunteering at the Centre, and their effects on my writing. I argue that my inside/outside-writer/researcher perspective has furthered understanding and helped shape my stories. Each chapter of the commentary examines one aspect of diasporic experience, and how it has influenced and inspired my creative practice. Writing from inside Leicester's Irish community has offered me a unique insight into diasporic life, which triggered story ideas and offered other useful lines of research. It also became clear, once I started absorbing primary and theoretical texts relating to Irish Diaspora and post-colonial theory, that there were visible and invisible forces at play behind individual experiences. These forces have impacted on the first, second and third generation Irish emigrants. My thesis attempts to come to terms with these cultural, social and economic forces through creative practice.
Subjects/Keywords: Thesis
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APA ·
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Export
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Manager
APA (6th Edition):
Cusack, P. L. (2019). The mad road : a creative exploration of Irish diasporic experience. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.11335904.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793998
Chicago Manual of Style (16th Edition):
Cusack, Paul L. “The mad road : a creative exploration of Irish diasporic experience.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.11335904.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793998.
MLA Handbook (7th Edition):
Cusack, Paul L. “The mad road : a creative exploration of Irish diasporic experience.” 2019. Web. 18 Feb 2020.
Vancouver:
Cusack PL. The mad road : a creative exploration of Irish diasporic experience. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.11335904.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793998.
Council of Science Editors:
Cusack PL. The mad road : a creative exploration of Irish diasporic experience. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.11335904.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793998
University of Leicester
15.
Barmanpek, Ufuk.
Relationship between personality traits and vocational interests : a multi-faceted study.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10319564.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794055
► Personality traits and vocational interests are important constructs of the individual differences that exist in the many sub-fields of psychology. Many studies have examined one…
(more)
▼ Personality traits and vocational interests are important constructs of the individual differences that exist in the many sub-fields of psychology. Many studies have examined one or both, and indeed the associations between these constructs. Most researchers have investigated these associations by conceptualising and measuring a typical model of the 'Big Five' - representing the 'bright' side of personality - and RIASEC vocational interests. However, although few studies have investigated the association between the 'dark' side of personality and vocational interests, no study has examined these associations by considering both the 'bright' and 'dark' sides of personality. This research investigates the relationship between personality traits and vocational interests by examining the 'dark' (i.e., Dark Triad) and 'bright' (i.e., HEXACO) sides of personality traits with vocational interests (i.e., RIASEC). These associations were investigated via four studies: longitudinal, cross-groups, cross-cultural, and the moderation effect of values on these associations within samples from undergraduates from Turkey (N=1,026) and the UK (N=445), and Turkish working adults (N=320). Overall, the conclusions of this thesis are: (i) the relationship between personality traits and vocational interests was generalizable and most likely did not differ across time, groups or cultures; (ii) concerning the relationships between the dimensions of vocational interests and personality, Enterprising was consistently associated with several types of personality: Extraversion and Dark Triad personality types were positively related to Enterprising, while Honesty-humility was negatively related to Enterprising across time, groups, and cultures, suggesting that these variables could be considered together to provide a context when psychological variables were examined within the context of the resultant relationships between personality and Enterprising; (iii) although values, personality, and vocational interests were shown to be interrelated, values were not generally observed to moderate this relationship, though with a few exceptions. Future research and the practical implications of these findings are also discussed.
Subjects/Keywords: Thesis
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APA ·
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Export
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Manager
APA (6th Edition):
Barmanpek, U. (2019). Relationship between personality traits and vocational interests : a multi-faceted study. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10319564.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794055
Chicago Manual of Style (16th Edition):
Barmanpek, Ufuk. “Relationship between personality traits and vocational interests : a multi-faceted study.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10319564.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794055.
MLA Handbook (7th Edition):
Barmanpek, Ufuk. “Relationship between personality traits and vocational interests : a multi-faceted study.” 2019. Web. 18 Feb 2020.
Vancouver:
Barmanpek U. Relationship between personality traits and vocational interests : a multi-faceted study. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10319564.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794055.
Council of Science Editors:
Barmanpek U. Relationship between personality traits and vocational interests : a multi-faceted study. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10319564.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794055
University of Leicester
16.
Kucharska, Joanna M.
Compassion focused approaches to nurse mentoring.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.11108729.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794026
► This thesis explored the delivery of Compassion Focused Approaches (CFA) and Mindfulness Based Interventions (MBIs) to support the training of healthcare professionals. Preliminary information from…
(more)
▼ This thesis explored the delivery of Compassion Focused Approaches (CFA) and Mindfulness Based Interventions (MBIs) to support the training of healthcare professionals. Preliminary information from existing narrative reviews regarding the implementation of MBIs for Trainee Psychological Therapists (TPTs) have demonstrated potential benefits for TPTs. The systematic review aimed to identify specific areas of improvement for TPTs following their participation in MBIs. Nineteen studies of medium to high quality met the inclusion criteria. The review highlighted that MBIs have a positive impact on some areas of TPTs' psychological wellbeing, specifically on anxiety. Further, TPTs' therapeutic skills such as empathy, self-compassion, mindfulness skills and TPTs' perceived 'therapist self-efficacy' improved. Factors influencing fidelity in the delivery of the MBI amongst other issues may have influenced the outcomes. Enhancing the underexplored nurse mentor-mentee relationship may improve the retention of pre-registration nurses. The empirical study investigated the impact of a Compassion Focused Approaches to Nurse Mentoring Programme (CFA-MP) on nurse mentors and their mentoring practice. A repeated measures mixed methods empirical study investigated the application of CFA-MP. Emergent qualitative evidence suggested that CFA-MP is helpful in facilitating the mentoring processes and that its positive impact remained over a period of at least at the 12 months follow-up. The lack of statistical power and significant gaps in participants' responses led to the quantitative analyses being unable to detect, any measureable impact of CFA-MP on nurse mentors. A qualitative service evaluation of a CFA-MP aimed to identify the key concepts in CFA that can be applied to and assist with the nurse mentoring process. Three themes emerged from the thematic analysis: 'Utility of the Model' 'Receptiveness' and 'Learning'. More research is necessary to investigate whether CFA-MP would strengthen the mentor-mentee relationship.
Subjects/Keywords: Thesis
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APA (6th Edition):
Kucharska, J. M. (2019). Compassion focused approaches to nurse mentoring. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.11108729.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794026
Chicago Manual of Style (16th Edition):
Kucharska, Joanna M. “Compassion focused approaches to nurse mentoring.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.11108729.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794026.
MLA Handbook (7th Edition):
Kucharska, Joanna M. “Compassion focused approaches to nurse mentoring.” 2019. Web. 18 Feb 2020.
Vancouver:
Kucharska JM. Compassion focused approaches to nurse mentoring. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.11108729.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794026.
Council of Science Editors:
Kucharska JM. Compassion focused approaches to nurse mentoring. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.11108729.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794026
University of Leicester
17.
Brasseur, Laurence.
Decentring the museum : examining young people's perceptions and experiences from a sociocultural perspective.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.11335829.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794001
► The relationship between young people and museums has been a topic of discussion since the late 1970s. Many developments have been observed in this respect,…
(more)
▼ The relationship between young people and museums has been a topic of discussion since the late 1970s. Many developments have been observed in this respect, yet some museums still find it challenging to engage with young people. Furthermore, the debate surrounding this relationship is often underpinned by unhelpful generalisations about young people that impede thinking and practice; for example, that young people lack interest in museums or find them boring. Previous research has principally investigated the subject through an 'education and learning' lens and from a perspective that takes museums as the starting point. This thesis aims to enrich our understanding by taking a sociocultural perspective and by centring the focus on young people. The thesis, therefore, actively seeks to decentre the museum: theoretically, by using an interdisciplinary framework; and practically, by conducting fieldwork outside museums. Through a qualitative approach, this study places young people's experiences and perceptions of museums in a wider social and cultural context. Focus groups were conducted with young people aged 12-21 in youth clubs in Luxembourg. This thesis reveals the complex and nuanced ways in which the focus-group participants think about museums in relation to their everyday lives. It also highlights the tensions and ambivalence underlying their perceptions and experiences. Furthermore, the study shows that the power inequalities that young people face in social life are likely to be perpetuated in the museum. Indeed, the participants' experiences of museums are shaped, in large part, by lack of individual choice. Visits that are enforced by facilitators, such as the school and the family, can create barriers to engagement. This thesis makes the case that it is important for museums and facilitators to acknowledge the diversity of young people, hear and value their points of view, and respect their autonomy and freedom of choice.
Subjects/Keywords: Thesis
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APA (6th Edition):
Brasseur, L. (2019). Decentring the museum : examining young people's perceptions and experiences from a sociocultural perspective. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.11335829.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794001
Chicago Manual of Style (16th Edition):
Brasseur, Laurence. “Decentring the museum : examining young people's perceptions and experiences from a sociocultural perspective.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.11335829.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794001.
MLA Handbook (7th Edition):
Brasseur, Laurence. “Decentring the museum : examining young people's perceptions and experiences from a sociocultural perspective.” 2019. Web. 18 Feb 2020.
Vancouver:
Brasseur L. Decentring the museum : examining young people's perceptions and experiences from a sociocultural perspective. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.11335829.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794001.
Council of Science Editors:
Brasseur L. Decentring the museum : examining young people's perceptions and experiences from a sociocultural perspective. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.11335829.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794001
University of Leicester
18.
Hawkins, Claudette D.
Repeat victimisation in online fraud : the 'ideal' and 'real' victims of fraud.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10319300.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794057
► Drawing upon qualitative interviews as a primary research method with repeat and single victims of fraud, this study found that the impact of fraud is…
(more)
▼ Drawing upon qualitative interviews as a primary research method with repeat and single victims of fraud, this study found that the impact of fraud is a highly personalised and interactive experience where both macro and micro societal elements play a role in the way victims of fraud experience victimisation. Coping strategies appeared to influence the severity of fraud, therefore there is very little difference between repeat and single victims in terms of the impact, although some repeat victims experienced a greater sense of shame. Moreover, both single and repeat victims used a variety of coping strategies to hide their victim identity, notably from the stigma associated with victimhood in fraud. Avoiding the victim label was a strong theme throughout, particularly for repeat victims who used 'covering' and 'downplaying' in an attempt to minimise or deny a repeat victim status. Rather than victimhood being experienced as a separate event, this study found a continuum emerged where it was discovered that there were a number of different trajectories to a 'journey of acceptance'. This study offers new insights into understanding why some victims appear to reject or accept the victim label, whilst recognising that the different trajectories towards repeat victimisation are not confined to a distinct event but more broadly emanate from the victim's own environment and relationships.
Subjects/Keywords: Thesis
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APA (6th Edition):
Hawkins, C. D. (2019). Repeat victimisation in online fraud : the 'ideal' and 'real' victims of fraud. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10319300.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794057
Chicago Manual of Style (16th Edition):
Hawkins, Claudette D. “Repeat victimisation in online fraud : the 'ideal' and 'real' victims of fraud.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10319300.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794057.
MLA Handbook (7th Edition):
Hawkins, Claudette D. “Repeat victimisation in online fraud : the 'ideal' and 'real' victims of fraud.” 2019. Web. 18 Feb 2020.
Vancouver:
Hawkins CD. Repeat victimisation in online fraud : the 'ideal' and 'real' victims of fraud. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10319300.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794057.
Council of Science Editors:
Hawkins CD. Repeat victimisation in online fraud : the 'ideal' and 'real' victims of fraud. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10319300.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794057
University of Leicester
19.
Lai, Chi Kin.
Celebrity endorsement : a qualitative study of chain tutoring centres in the Hong Kong shadow education sector.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10540571.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794034
► Celebrity endorsement plays a key role in modern marketing, which is widely employed by companies and studied by researchers. Past studies in the literature on…
(more)
▼ Celebrity endorsement plays a key role in modern marketing, which is widely employed by companies and studied by researchers. Past studies in the literature on celebrity endorsement have concentrated on consumer assessment to identify the factors that influence the selection of celebrity endorsers for helping promotion and impacting consumer purchase intention. Studies on celebrity endorsement and the marketisation of education have under-examined the phenomenon of celebrity tutors in the Hong Kong shadow education sector. Through a qualitative approach, this thesis aims to explore how and why the chain tutoring centres in Hong Kong create and maintain celebrity tutors. Semi-structured interviews were conducted with a variety of practitioners from the main chain tutoring centres and then thematic data analysis was undertaken. The celebrity tutors are found to be a human brand established through celebrification. The performance of celebrity tutors was associated with a multiplicity of role-practices such as being entertainers, educators, entrepreneurs and specifically idols (Tutor Kings and Queens), and their relationship with the media to fulfil these. Although a hyperbolic emphasis is placed on the tutors' physical attractiveness and credibility as key features for their success, both established and emerging celebrity tutors have been developing autonomous practices and performances in creating and maintaining their celebrity status and symbolic meanings. The performance of celebrity tutors reflects the celebritisation of shadow education as the industry norm through the idolisation of tutoring and fan culture. The participants themselves drew parallels between celebrity tutors and branded goods, showing that they acknowledge shadow education within a market logic. This explains the swift marketisation of shadow, rather than tertiary, education in an Asian context. There are co-branding and endorsement between celebrity tutors, chain tutoring centres and drinks/toiletries, which are worthy of further study.
Subjects/Keywords: Thesis
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Manager
APA (6th Edition):
Lai, C. K. (2019). Celebrity endorsement : a qualitative study of chain tutoring centres in the Hong Kong shadow education sector. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10540571.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794034
Chicago Manual of Style (16th Edition):
Lai, Chi Kin. “Celebrity endorsement : a qualitative study of chain tutoring centres in the Hong Kong shadow education sector.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10540571.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794034.
MLA Handbook (7th Edition):
Lai, Chi Kin. “Celebrity endorsement : a qualitative study of chain tutoring centres in the Hong Kong shadow education sector.” 2019. Web. 18 Feb 2020.
Vancouver:
Lai CK. Celebrity endorsement : a qualitative study of chain tutoring centres in the Hong Kong shadow education sector. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10540571.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794034.
Council of Science Editors:
Lai CK. Celebrity endorsement : a qualitative study of chain tutoring centres in the Hong Kong shadow education sector. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10540571.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794034
University of Leicester
20.
Almutawa, Fawwaz A. O.
An investigation into the role of school leadership in school improvement, including teachers' and students' development : a case study of two Saudi Arabian high schools.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10303775.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794084
► Since Saudi Arabia began enthusiastically developing its position in the world, excellence in education has come to the fore asa key driver to the country's…
(more)
▼ Since Saudi Arabia began enthusiastically developing its position in the world, excellence in education has come to the fore asa key driver to the country's growth. However, school improvement has received insufficient attention from educators, policy makers, and scholars. This has resulted in Saudi schools suffering from a dearth of empirical studies designed to explore their needs in terms of the professional development of teachers to benefit students. In response, this study was conducted to fill in the current gap arising from the lack of empirical studies in this particular field, through considering the role of school leadership in school improvement and the associated requirements for the professional development of teachers and students in relation to school improvement. The present study design relied on interpretivist qualitative methods, including documentary analysis, face-to-face semi-structured interviews and group interviews. The participants involved in the study were two school leaders, two school deputies, two student advisors and twelve teachers (face-to-face semi-structured interviews), and four groups of nine students (group interviews). The data was analysed using thematic analysis techniquesfollowing an interpretative coding approach. The findings of the study reveal school leadership plays a significant role in school improvement. This is due to the authority of the school leadership team over essential factors related to the quality of teaching and learning, i.e. leadership style, school culture, inclusion,student voice, individual differences, school curriculum, school-parent relationships, PLCs, teaching effectiveness and class size. The findings also confirm that school improvement is also affected by several external factors; i.e. educational policy, the context of the school, the services available in the school district, society, lifestyle, external relationships, and the media. Although the result of this study is non-generalizable, it can be used to inform practitioners, researchers, and policy makers about how best to ensure school improvement in Saudi Arabia.
Subjects/Keywords: Thesis
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APA (6th Edition):
Almutawa, F. A. O. (2019). An investigation into the role of school leadership in school improvement, including teachers' and students' development : a case study of two Saudi Arabian high schools. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10303775.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794084
Chicago Manual of Style (16th Edition):
Almutawa, Fawwaz A O. “An investigation into the role of school leadership in school improvement, including teachers' and students' development : a case study of two Saudi Arabian high schools.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10303775.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794084.
MLA Handbook (7th Edition):
Almutawa, Fawwaz A O. “An investigation into the role of school leadership in school improvement, including teachers' and students' development : a case study of two Saudi Arabian high schools.” 2019. Web. 18 Feb 2020.
Vancouver:
Almutawa FAO. An investigation into the role of school leadership in school improvement, including teachers' and students' development : a case study of two Saudi Arabian high schools. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10303775.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794084.
Council of Science Editors:
Almutawa FAO. An investigation into the role of school leadership in school improvement, including teachers' and students' development : a case study of two Saudi Arabian high schools. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10303775.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794084
University of Leicester
21.
Way, Laura A.
Just typical girls? : an exploration of older women's construction and maintenance of punk identities.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10321445.v2
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794046
► This thesis examines the construction and maintenance of punk identities by ageing, or older, (punk) women. Recent scholarship on post-youth subcultural involvement demonstrates some evidence…
(more)
▼ This thesis examines the construction and maintenance of punk identities by ageing, or older, (punk) women. Recent scholarship on post-youth subcultural involvement demonstrates some evidence of exploring the interplay between age, gender and subculture yet still lacks any research which solely focuses on the experiences of older punk women. Historically, women have been marginalised in subcultural scholarship and this has been more so the case for ageing, or older, women. In line with the feminist research values, this thesis therefore gives voice to a previously marginalised sample. The research utilised a methodology informed by a feminist and inductive approach. Data was analysed from 16 semi-structured interviews (one paired) and 5 e-mail interviews. A set of common punk values were raised by the research participants which in turn informed, not determined, their relationship with dress, music and gigs. These punk values were also important for how the women negotiated punk identities as they aged. A career model is proposed for understanding how ageing women construct and maintain punk identities. This demonstrates the emergence of three main identity categories across the research sample: the 'toner downs', the 'consistent punks' and the 'never massively outrageous'. Reflecting on punk in their lives 'then' and 'now', the women demonstrated tensions between agency/structure with gender and social ageing highlighted as potential constraints on their construction and maintenance of punk identities.
Subjects/Keywords: Thesis
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APA (6th Edition):
Way, L. A. (2019). Just typical girls? : an exploration of older women's construction and maintenance of punk identities. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10321445.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794046
Chicago Manual of Style (16th Edition):
Way, Laura A. “Just typical girls? : an exploration of older women's construction and maintenance of punk identities.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10321445.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794046.
MLA Handbook (7th Edition):
Way, Laura A. “Just typical girls? : an exploration of older women's construction and maintenance of punk identities.” 2019. Web. 18 Feb 2020.
Vancouver:
Way LA. Just typical girls? : an exploration of older women's construction and maintenance of punk identities. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10321445.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794046.
Council of Science Editors:
Way LA. Just typical girls? : an exploration of older women's construction and maintenance of punk identities. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10321445.v2 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794046
University of Leicester
22.
Alharbi, Abdulrahman N.
Modelling of droplet drying mechanisms.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10303769.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794085
► This thesis aims to develop an understanding of the drying mechanisms of a liquid droplet containing solid particles by consideration of the heat and mass…
(more)
▼ This thesis aims to develop an understanding of the drying mechanisms of a liquid droplet containing solid particles by consideration of the heat and mass transfer processes involved and mechanical behaviour of the porous material during drying. The previous studies mostly used methods to solve coupled heat and mass transfer equations using mathematical tools. This study contributes to an understanding of the mechanical behaviour of drying a single droplet containing solids. Modelling of the drying mechanisms involves heat, mass transfer and changing of the droplet size. An inflation model was added to the drying model to describe the particle expansion under internal vapour pressure in the second drying stage when the droplet temperature is higher than the boiling temperature. COMSOL Multiphysics ® finite element software was used to solve the governing equations. The numerical results were validated using analytical solutions, existing experimental data from the literature and published numerical studies. Different model parameters were varied to simulate their effect on droplet temperature, mass profiles and also the effect on the timing of the shell. Higher air velocity results in faster formation of the shell. Increasing the air temperature generates high internal pressure which in turn produces significant inflation of a porous particle. The mechanical expansion is considered using concepts adapted from poroelasticity, whereby the deformation of the porous structure is strongly influenced by the pore pressure arising from heat and mass transfer as well as evaporation of the solvent in the pore space. Qualitative agreement has been obtained with published experimental results, highlighting the need for appropriate characterisation of the mechanical properties of the porous matrix which evolve as functions of porosity and temperature during the drying process.
Subjects/Keywords: Thesis
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APA (6th Edition):
Alharbi, A. N. (2019). Modelling of droplet drying mechanisms. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10303769.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794085
Chicago Manual of Style (16th Edition):
Alharbi, Abdulrahman N. “Modelling of droplet drying mechanisms.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10303769.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794085.
MLA Handbook (7th Edition):
Alharbi, Abdulrahman N. “Modelling of droplet drying mechanisms.” 2019. Web. 18 Feb 2020.
Vancouver:
Alharbi AN. Modelling of droplet drying mechanisms. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10303769.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794085.
Council of Science Editors:
Alharbi AN. Modelling of droplet drying mechanisms. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10303769.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794085
University of Leicester
23.
Mwale, Nicholas K.
Defining the interacting regions of the translational regulators polyadenylate binding protein (PABP) 1 and the programmed cell death protein (Pdcd) 4.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.11335802.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794002
► Programmed Cell Death protein (Pdcd) 4 is a highly conserved nuclear/cytoplasmic shuttling and RNA binding protein that has been shown to suppress tumour progression by…
(more)
▼ Programmed Cell Death protein (Pdcd) 4 is a highly conserved nuclear/cytoplasmic shuttling and RNA binding protein that has been shown to suppress tumour progression by regulating transcription and translation and is therefore considered a promising target for anti-cancer therapies. Until recently regulation of translation inhibition was exclusively thought to be eIF4A mediated, and was shown to involve the interaction of the tandem MA3 domains of Pdcd4 with the RNA helicase, eIF4A. Recent evidence has shown that Pdcd4 can also inhibit translation in an eIF4A independent mechanism, via direct interactions with both the Poly Adenylate Binding Protein (PABP) 1 and specific regions of mRNA. The work in this thesis describes the crystallisation of the RRM 2 construct that confirmed previously described structural features. It also describes how models of RRM 3 and RRM 2-3 constructs were designed due to the constraints of obtaining respective crystals. The latter chapters contain NMR chemical shift perturbation experiments that identified the RNA Recognition Motifs (RRM) 2 and 3 of PABP1 as the main contact interface with the Pdcd4 protein. These chapters also showed successful generation of isotopically labeled individual RRM 2 and RRM 3 and tandem RRM 2-3 constructs that enabled sequence-specific backbone assignments to be obtained using triple resonance NMR experiments. This allowed for structural characterisation of the RRM2-3 region and identification of specific residues (primarily the β strands and linker region between RRM 2 and RRM 3) that are believed to form part of the Pdcd4 binding site. Analogous experiments suggest the RNA Binding Region (RBD) and middle MA3 domains of Pdcd4 contain the main PABP1 binding sites. The stoichiometry of the complex suggests a 1:1 transient interaction in solution with a Kd value in the low micromolar region.
Subjects/Keywords: Thesis
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APA ·
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MLA ·
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Export
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APA (6th Edition):
Mwale, N. K. (2019). Defining the interacting regions of the translational regulators polyadenylate binding protein (PABP) 1 and the programmed cell death protein (Pdcd) 4. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.11335802.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794002
Chicago Manual of Style (16th Edition):
Mwale, Nicholas K. “Defining the interacting regions of the translational regulators polyadenylate binding protein (PABP) 1 and the programmed cell death protein (Pdcd) 4.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.11335802.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794002.
MLA Handbook (7th Edition):
Mwale, Nicholas K. “Defining the interacting regions of the translational regulators polyadenylate binding protein (PABP) 1 and the programmed cell death protein (Pdcd) 4.” 2019. Web. 18 Feb 2020.
Vancouver:
Mwale NK. Defining the interacting regions of the translational regulators polyadenylate binding protein (PABP) 1 and the programmed cell death protein (Pdcd) 4. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.11335802.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794002.
Council of Science Editors:
Mwale NK. Defining the interacting regions of the translational regulators polyadenylate binding protein (PABP) 1 and the programmed cell death protein (Pdcd) 4. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.11335802.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794002
University of Leicester
24.
Brazer, Goura.
Exploring stakeholders' perceptions of family and community involvement in the education of pupils of Black Caribbean origin.
Degree: Thesis (EdD), 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10304702.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794066
► There are many reasons for developing school-family-community partnerships. Partnerships can improve school programs, provide services to families, increase parents' skills, connect families and most importantly,…
(more)
▼ There are many reasons for developing school-family-community partnerships. Partnerships can improve school programs, provide services to families, increase parents' skills, connect families and most importantly, improve and enhance pupils' academic performance and learning experiences. This study explores stakeholders' perceptions of family and community involvement in the education of pupils of Black Caribbean origin. It was conducted at one primary school in inner London and focused exclusively on the perceptions of stakeholders of the Black Caribbean community. The basic tenet underlying the study is that all knowledge is constructed. It therefore adopts a constructivist epistemological perspective and utilises semi-structured interviews and a focus group. This study examines why school-family-community partnerships are necessary and the challenges faced in establishing, developing and sustaining them, specifically with this group of learners, many of whom are underachieving not only in British schools but at schools worldwide. The relative underachievement of this group of pupils has been a cause for concern not only for their parents and families but for educators as well, both at the local and national levels. The research highlights that in order to give these learners the best educational outcomes; families and the community should play a key role in supporting them. The findings reveal that the school has put a number of measures in place but needs to consider how it can harness the available resources from families and from within the community to support not only this group of learners but for all learners at the school.
Subjects/Keywords: Thesis
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APA (6th Edition):
Brazer, G. (2019). Exploring stakeholders' perceptions of family and community involvement in the education of pupils of Black Caribbean origin. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10304702.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794066
Chicago Manual of Style (16th Edition):
Brazer, Goura. “Exploring stakeholders' perceptions of family and community involvement in the education of pupils of Black Caribbean origin.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10304702.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794066.
MLA Handbook (7th Edition):
Brazer, Goura. “Exploring stakeholders' perceptions of family and community involvement in the education of pupils of Black Caribbean origin.” 2019. Web. 18 Feb 2020.
Vancouver:
Brazer G. Exploring stakeholders' perceptions of family and community involvement in the education of pupils of Black Caribbean origin. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10304702.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794066.
Council of Science Editors:
Brazer G. Exploring stakeholders' perceptions of family and community involvement in the education of pupils of Black Caribbean origin. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10304702.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794066
University of Leicester
25.
Adams, Grace E.
Understanding the contribution of inositol phosphate signalling to class-1 HDAC complex function.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10298168.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794090
► Class 1 histone deacetylases (HDACs) regulate chromatin confirmation and gene expression through recruitment to co-repressor complexes. Recently, it was shown that HDAC3/SMRT binds and is…
(more)
▼ Class 1 histone deacetylases (HDACs) regulate chromatin confirmation and gene expression through recruitment to co-repressor complexes. Recently, it was shown that HDAC3/SMRT binds and is regulated by inositol phosphates (IP) in vitro. Additionally, complex activity of HDAC1/MTA1 and HDAC1/MIDEAS is enhanced by the addition of IPs in vitro, indicating conserved regulation. In this work, I aimed to alter the level of IPs present in the cells through overexpression of a kinase, IPMK, and two phosphatases, PTEN and SopB, and determine the effect on HDAC activity in vivo. In addition, I utilised an IPMK knockout embryonic stem (ES) cell line and generated inducible rescues through a PiggyBac TET system to establish if large scale depletions of IP levels alter HDAC activity. We revealed that manipulation of IP through the overexpression of IPMK, PTEN and SopB does not influence global HDAC activity or histone acetylation levels. Isolation of overexpressed HDAC3/SMRT in concert with these enzymes, revealed differences in HDAC3/SMRT complex activity, however, these differences did not correlate with altered IP levels. Analysis of global HDAC activity, isolated complex activity and HDAC3 target genes in IPMK knockout and rescue ES cell lines further revealed minimal changes. In conclusion, we were unable to show that IPs regulated the activity of class I HDAC complexes in vivo. IPMK, HDAC1 and HDAC3 null mice all exhibit early embryonic lethality suggesting they play essential roles in embryogenesis. Upon differentiation of TET-IPMK cells, embryoid bodies revealed loss of IPMK leads to increased cardiomyocyte markers and decreased formation of neuroectoderm progenitors. Therefore, emphasizing IPMKs important role in gene regulation during embryogenesis. Our data suggests, that this is not through direct regulation of HDAC activity, thus highlighting an undiscovered nuclear role for IPMK.
Subjects/Keywords: Thesis
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APA (6th Edition):
Adams, G. E. (2019). Understanding the contribution of inositol phosphate signalling to class-1 HDAC complex function. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10298168.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794090
Chicago Manual of Style (16th Edition):
Adams, Grace E. “Understanding the contribution of inositol phosphate signalling to class-1 HDAC complex function.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10298168.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794090.
MLA Handbook (7th Edition):
Adams, Grace E. “Understanding the contribution of inositol phosphate signalling to class-1 HDAC complex function.” 2019. Web. 18 Feb 2020.
Vancouver:
Adams GE. Understanding the contribution of inositol phosphate signalling to class-1 HDAC complex function. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10298168.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794090.
Council of Science Editors:
Adams GE. Understanding the contribution of inositol phosphate signalling to class-1 HDAC complex function. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10298168.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794090
University of Leicester
26.
Cohen, Joshua.
British antifascism and the Holocaust, 1945-67.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10320350.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794052
► This thesis explores the extent to which the Holocaust shaped British antifascism in the period 1945-1967. It makes an original contribution in setting out the…
(more)
▼ This thesis explores the extent to which the Holocaust shaped British antifascism in the period 1945-1967. It makes an original contribution in setting out the first dedicated analysis of the relationship between consciousness of the Nazi genocide and motivations for confronting fascism in Britain. The study has interrogated institutional archival records to assess the presence of the Holocaust in the private discourses, propaganda and campaign strategies of a wide variety of antifascist organisations. Personal motivations for antifascist activism have been engaged with through analysis of memoirs, autobiographies and oral histories. The thesis will demonstrate that the Holocaust was often absent from antifascist rhetoric, and so should be decentred from understandings that assume constant affinity between Holocaust remembrance and British antifascism. Instead, antifascism in this period was often conceptualised in a patriotic framework, as coda to the Second World War, or viewed through left-wing analyses of class struggle which obscured fascism's 'racial' victims. However, the central importance of this study lies in its revealing that a Holocaust-inspired resistance to fascism was emerging in this period and beginning to co-exist with patriotic and other forms of antifascism. The 'lessons' of the Holocaust for antifascists were the subject of agonised internal disputes and became a point of open conflict between militant and establishment Anglo-Jewish organisations. The genocide was also politicised in a number of antifascist campaigns, including on the Left and in the name of civil liberties. The thesis therefore argues for 1945-67 as a vital transitional period when use of the Holocaust as a weapon against fascism was developing, albeit sometimes on the fringes of antifascist discourse. In this way, the period presaged the more confident later invocations of the genocide, including in activism against the National Front in the 1970s.
Subjects/Keywords: Thesis
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APA (6th Edition):
Cohen, J. (2019). British antifascism and the Holocaust, 1945-67. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10320350.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794052
Chicago Manual of Style (16th Edition):
Cohen, Joshua. “British antifascism and the Holocaust, 1945-67.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10320350.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794052.
MLA Handbook (7th Edition):
Cohen, Joshua. “British antifascism and the Holocaust, 1945-67.” 2019. Web. 18 Feb 2020.
Vancouver:
Cohen J. British antifascism and the Holocaust, 1945-67. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10320350.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794052.
Council of Science Editors:
Cohen J. British antifascism and the Holocaust, 1945-67. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10320350.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794052
University of Leicester
27.
Dye, Bruce G.
"What can I possibly achieve as a necessity-driven entrepreneur?" : the impact of the cultural component of the entrepreneurial ecology on possible future entrepreneur selves.
Degree: Thesis (D.Soc.Sci.), 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10319627.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794054
► This study focuses on necessity-driven entrepreneurs, seated within the entrepreneurial ecology where culture and individuals intersect. It is responding to the poor understanding of necessity-driven…
(more)
▼ This study focuses on necessity-driven entrepreneurs, seated within the entrepreneurial ecology where culture and individuals intersect. It is responding to the poor understanding of necessity-driven entrepreneurs in extant literature. Specifically, there is not a comprehensive, theoretically informed understanding of necessity-driven entrepreneurs and how entering entrepreneurship from a position of social disadvantage impacts aspirations and behaviors. As such, the study is concerned with how culture impacts entrepreneurial aspirations and resulting entrepreneurial behavior, framed by theories of entrepreneurship, culture, possible future selves, and the entrepreneurial ecology. The study was guided by a general research question that probed the impact of culture on the possible future selves of necessity-driven entrepreneurs. It was supported by specific research questions focused on necessity-driven entrepreneurs' needs, dreams, fears, and the impact of culture. A systematic, yet flexible, qualitative research process was used, informed by interpretivism and constructivism. Thematic analysis was used to facilitate discovery of propositions that can apply to other similar, necessity-driven entrepreneurs in similar contexts. It was found that the needs necessity-driven entrepreneurs are trying to meet are likely to be non-financial and their entrepreneurial dreams and fears are distinctly social. Their belief that they can achieve their needs through entrepreneurship and their possible future entrepreneur selves are sensitive to signals from culture. It was also found that necessity driven entrepreneurs are likely to interpret signals from culture that are encouraging, discouraging, mixed, and sometimes insulting and derogatory. Discouraging signals negatively impact possible future entrepreneur selves and result in risk averse behavior. Finally, it was found that necessity-driven entrepreneurs' social disadvantage may prompt them to act on long-standing entrepreneurial aspirations. To better understand necessity-driven entrepreneurship, we need to broaden our lens beyond assumptions that it is necessarily a profit-motivated, individual-centric activity and simultaneously consider the role that culture plays, within the context of the entire entrepreneurial ecology.
Subjects/Keywords: Thesis
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APA (6th Edition):
Dye, B. G. (2019). "What can I possibly achieve as a necessity-driven entrepreneur?" : the impact of the cultural component of the entrepreneurial ecology on possible future entrepreneur selves. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10319627.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794054
Chicago Manual of Style (16th Edition):
Dye, Bruce G. “"What can I possibly achieve as a necessity-driven entrepreneur?" : the impact of the cultural component of the entrepreneurial ecology on possible future entrepreneur selves.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10319627.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794054.
MLA Handbook (7th Edition):
Dye, Bruce G. “"What can I possibly achieve as a necessity-driven entrepreneur?" : the impact of the cultural component of the entrepreneurial ecology on possible future entrepreneur selves.” 2019. Web. 18 Feb 2020.
Vancouver:
Dye BG. "What can I possibly achieve as a necessity-driven entrepreneur?" : the impact of the cultural component of the entrepreneurial ecology on possible future entrepreneur selves. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10319627.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794054.
Council of Science Editors:
Dye BG. "What can I possibly achieve as a necessity-driven entrepreneur?" : the impact of the cultural component of the entrepreneurial ecology on possible future entrepreneur selves. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10319627.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794054
University of Leicester
28.
Kadhim, Fateh O.
The role Of CARD9 in the pathogensis of IgA nephropathy.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.11108711.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794027
► IgA nephropathy (IgAN) is a common cause of primary glomerulonephritis worldwide. It is characterised by the deposition of poorly galactosylated IgA1 immune complexes in the…
(more)
▼ IgA nephropathy (IgAN) is a common cause of primary glomerulonephritis worldwide. It is characterised by the deposition of poorly galactosylated IgA1 immune complexes in the renal mesangium, leading to end stage renal damage in 30% of patients. At present, the pathogenesis of IgAN is not well understood. IgAN GWAS studies revealed an association between IgAN and a SNP within the coding sequence of the CARD9 gene. CARD9 is an essential mediator of the innate immune system, however its place in the pathogenesis of IgAN has yet to be defined. The aim of this study was to investigate the role of CARD9 in IgAN. In this project, the expression of CARD9 mRNA was higher in; peripheral blood mononuclear cells (PBMCs) from IgAN patients compared to healthy controls, and in IgAN renal biopsy tissue compared to other renal diseases. rs4077515-T was associated with increased synthesis of IgA and poorly O-galactosylated IgA1 by activated PMBCs from both IgAN patients and healthy subjects. Immunohistochemistry demonstrated CARD9 protein in both the glomerular and tubulointerstitial compartments in IgAN and western blotting revealed the presence of CARD9 in cell lysates from human renal cells. Human mesangial cells with the rs4077515-T allele synthesised significantly more of the pro-inflammatory cytokine IL-6 following exposure to IgA1. Similar increases were seen in mRNA coding for IL-6, IL-6 signal transducer (IL-6ST) and monocyte chemoattractant protein 1(MCP-1), suggesting that the presence of rs4077515-T could result in a greater inflammatory response to mesangial IgA deposition in IgAN. A significant association between rs4077515-T and the likelihood of renal function decline in Chinese IgAN patients was observed. This study provides an insight into the contribution of CARD9 in; the generation of poorly O-galactosylated IgA1 by human PBMCs, the response of mesangial cells to IgA deposition in IgAN, the likelihood of renal function decline in IgAN.
Subjects/Keywords: Thesis
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MLA ·
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Export
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APA (6th Edition):
Kadhim, F. O. (2019). The role Of CARD9 in the pathogensis of IgA nephropathy. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.11108711.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794027
Chicago Manual of Style (16th Edition):
Kadhim, Fateh O. “The role Of CARD9 in the pathogensis of IgA nephropathy.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.11108711.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794027.
MLA Handbook (7th Edition):
Kadhim, Fateh O. “The role Of CARD9 in the pathogensis of IgA nephropathy.” 2019. Web. 18 Feb 2020.
Vancouver:
Kadhim FO. The role Of CARD9 in the pathogensis of IgA nephropathy. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.11108711.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794027.
Council of Science Editors:
Kadhim FO. The role Of CARD9 in the pathogensis of IgA nephropathy. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.11108711.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794027
University of Leicester
29.
Dayel, Anfal Bin.
Mapping the binding site of P2X7 receptor antagonists.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10303748.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794086
► The P2X7 receptor (P2X7R) is a ligand gated ion channel activated by high concentrations of ATP that are usually found in conditions of stress, cellular…
(more)
▼ The P2X7 receptor (P2X7R) is a ligand gated ion channel activated by high concentrations of ATP that are usually found in conditions of stress, cellular damage and disease. Selective P2X7R antagonists therefore may have therapeutic potential for treatment of several pathological conditions. Understanding how P2X7R antagonists act on the receptor is useful to facilitate drug design. In this thesis the molecular basis for several selective P2X7R antagonists has been investigated. This was done by using a range of chimeras and mutations between antagonist sensitive hP2X7R and antagonist insensitive hP2X1R. This work showed that the selective P2X7R antagonist AZ11645373 binds at the allosteric pocket between two adjacent subunits away from the orthosteric ATP binding pocket. Molecular docking of AZ11645373 is in line with effects of mutations on the sensitivity to the antagonist. The allosteric binding mode of AZ11645373 explains variation in antagonist sensitivity between human and rat P2X7Rs. Comparing the effects of allosteric point mutations of AZ11645373 with other previously characterized allosteric inhibitors demonstrated that there is a similar reduction in sensitivity with the F88A, T90V, D92A, F103A and V312A mutations. These allosteric mutations were used as a signature to identify the site of action for P2X7R antagonists ZINC58368839, KN-62, Brilliant Blue G and Calmidazolium. The combination of signature allosteric point mutations and molecular docking propose that ZINC58368839 has a mode of binding similar to AZ11645373. However, the binding site for the large molecule P2X7R antagonists KN-62, Brilliant Blue G and Calmidazolium appear to be more complex, because they not only bind at the allosteric site but also extend into the central cavity. In conclusion, this thesis has enhanced our knowledge of selective P2X7R antagonists and advanced a template to develop allosteric P2X7R inhibitors.
Subjects/Keywords: Thesis
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APA ·
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Export
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APA (6th Edition):
Dayel, A. B. (2019). Mapping the binding site of P2X7 receptor antagonists. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10303748.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794086
Chicago Manual of Style (16th Edition):
Dayel, Anfal Bin. “Mapping the binding site of P2X7 receptor antagonists.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10303748.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794086.
MLA Handbook (7th Edition):
Dayel, Anfal Bin. “Mapping the binding site of P2X7 receptor antagonists.” 2019. Web. 18 Feb 2020.
Vancouver:
Dayel AB. Mapping the binding site of P2X7 receptor antagonists. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10303748.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794086.
Council of Science Editors:
Dayel AB. Mapping the binding site of P2X7 receptor antagonists. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10303748.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794086
University of Leicester
30.
Alkhayyat, Heyam K. H.
Twisted tensor products of n-groupoids and crossed complexes.
Degree: PhD, 2019, University of Leicester
URL: https://doi.org/10.25392/leicester.data.10303655.v1
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794088
► For any 1-reduced simplicial setX, we define a crossed complex of groups PCrsX, which we define as a twisted tensor product of the crossed cobar…
(more)
▼ For any 1-reduced simplicial setX, we define a crossed complex of groups PCrsX, which we define as a twisted tensor product of the crossed cobar construction ΩCrsX and thef undamental crossed complexπX. In fact, we prove that PCrsXis contractible. Therefore PCrsXis a crossed complex model for the path space ofX. It is also an example of a crossed complex model of the total space of a fibration, ΩX−→PX−→X.This generalises from chain complexes to crossed complexes the theorem proved by J.F. Adams, and P. J. Hilton in their paper [3]. Our definition of twisted tensor products of crossed complexes also defines a twisted tensor product of n-groupoids, for all n. This comes from the fact that there is an equivalence of categories (∞-groupoids←→crossed complexes) which was proved by R. Brown and P. J. Higgins in their paper [12].We recall the classical Eilenberg-Zilber theorem for chain complexes, and its generalisation for crossed complexes, which show that the tensor product provides an algebraic model forthe Cartesian product of the fibration X−→X×Y−→Y.We also extend our theorems to 0-reduced simplicial sets X. In this case we generalise the crossed cobar construction ΩCrsX from 1-reduced simplicial sets to the group-completed crossed cobar constructionˆΩCrsXfor 0-reduced simplicial sets and define a crossed complex of groupoids PCrsX, a twisted tensor product with the twisted boundary maps∂Pn:PCrsnX= (ˆΩCrsX⊗φπX)n−→PCrsn−1= (ˆΩCrsX⊗φπX)n−1, ∂2= 0.We end by defining a contracting homotopy {ηn:PCrsnX→PCrsn+1X}which shows that this crossed complex of groupoids is still a model for the path space onX.
Subjects/Keywords: Thesis
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APA ·
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MLA ·
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Export
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APA (6th Edition):
Alkhayyat, H. K. H. (2019). Twisted tensor products of n-groupoids and crossed complexes. (Doctoral Dissertation). University of Leicester. Retrieved from https://doi.org/10.25392/leicester.data.10303655.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794088
Chicago Manual of Style (16th Edition):
Alkhayyat, Heyam K H. “Twisted tensor products of n-groupoids and crossed complexes.” 2019. Doctoral Dissertation, University of Leicester. Accessed February 18, 2020.
https://doi.org/10.25392/leicester.data.10303655.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794088.
MLA Handbook (7th Edition):
Alkhayyat, Heyam K H. “Twisted tensor products of n-groupoids and crossed complexes.” 2019. Web. 18 Feb 2020.
Vancouver:
Alkhayyat HKH. Twisted tensor products of n-groupoids and crossed complexes. [Internet] [Doctoral dissertation]. University of Leicester; 2019. [cited 2020 Feb 18].
Available from: https://doi.org/10.25392/leicester.data.10303655.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794088.
Council of Science Editors:
Alkhayyat HKH. Twisted tensor products of n-groupoids and crossed complexes. [Doctoral Dissertation]. University of Leicester; 2019. Available from: https://doi.org/10.25392/leicester.data.10303655.v1 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794088
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Open Access Theses and Dissertations
