You searched for subject:( superior temporal gyrus ).
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University of Arizona
1.
Wong, Bryan M.
Planum Temporale: Morphologic Taxonomy of the Superior Temporal Plane
.
Degree: 2019, University of Arizona
URL: http://hdl.handle.net/10150/636683 
► Background: Planum Temporale (PT) is a crucial neuroauditory structure located in the dorsal superior temporal plane (STP) posterior to Heschl’s gyrus (HG). The PT has…
(more)
▼ Background: Planum Temporale (PT) is a crucial neuroauditory structure located in the dorsal
superior temporal plane (STP) posterior to Heschl’s
gyrus (HG). The PT has been implicated in complex auditory function and is well known for its preponderance of leftward asymmetry in normal brains and classic “pie- shaped” morphology. While a majority of cases have easily identifiable PT and HG, there exist some cases in which distinguishability of these two structures is difficult due to morphological variation. The goal of this study is to create a taxonomy of PT morphological features in order to improve the sometimes difficult identification and differentiation of PT from surrounding structures. Methods: A total of 50 (100 hemispheres) healthy intact, high-resolution T1- weighted brain MRIs were obtained from Open Access Series of Imaging Studies (OASIS) and included in this retrospective study. There were 28 women and 22 men, all right-handed. Ages ranged from 18-57 (mean=26.44) years. A 3D cortical surface mesh (grey matter) for each brain was generated using FreeSurfer and manipulated to view the STP using BrainVISA Anatomist neuroimaging software. The PT was isolated from surrounding structures based on pre-defined anatomical criteria and subsequent surface area measurements, linear measurements and qualitative measures were made. Results: A total of four PT configurations were identified: (1) Pie-shaped [45%], (2) Trapezoid-shaped [27%], (3) Rectangular-shaped [19%], and (4) None [9%]. Mean surface areas of measurable PT configurations were: 511.96 mm2 for “Pie-shaped” (n=45), 517.36 mm2 for “Trapezoid-shaped” (n=27) and 472.12mm2 for “Rectangular-shaped” (n=19). The fourth category, “None” (n=9), was not calculable. There were significantly more “Trapezoid-shaped” PTs in females (p<.05). The “None” category occurred significantly more in males (p<.05) and in the right hemisphere (p<.05). Furthermore, the left hemisphere demonstrated significantly greater surface area for “Pie-shaped” PTs (p<.05). Conclusion: We believe that the proposed classifications is the first step in creating a comprehensive taxonomy of the STP. This will aid neuroanatomists, clinicians and students in terms of differentiation of sometimes complex topography of the STP.
Advisors/Committee Members: Musiek, Frank (advisor), Fuglevand, Andrew (committeemember), Cone, Barbara (committeemember), Kielar, Aneta (committeemember).
Subjects/Keywords: auditory cortex;
heschls gyrus;
planum temporale;
superior temporal plane;
taxonomy
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APA (6th Edition):
Wong, B. M. (2019). Planum Temporale: Morphologic Taxonomy of the Superior Temporal Plane
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/636683
Chicago Manual of Style (16th Edition):
Wong, Bryan M. “Planum Temporale: Morphologic Taxonomy of the Superior Temporal Plane
.” 2019. Doctoral Dissertation, University of Arizona. Accessed January 26, 2021.
http://hdl.handle.net/10150/636683.
MLA Handbook (7th Edition):
Wong, Bryan M. “Planum Temporale: Morphologic Taxonomy of the Superior Temporal Plane
.” 2019. Web. 26 Jan 2021.
Vancouver:
Wong BM. Planum Temporale: Morphologic Taxonomy of the Superior Temporal Plane
. [Internet] [Doctoral dissertation]. University of Arizona; 2019. [cited 2021 Jan 26].
Available from: http://hdl.handle.net/10150/636683.
Council of Science Editors:
Wong BM. Planum Temporale: Morphologic Taxonomy of the Superior Temporal Plane
. [Doctoral Dissertation]. University of Arizona; 2019. Available from: http://hdl.handle.net/10150/636683
2.
Roos, Magnus.
Speech Comprehension : Theoretical approaches and neural correlates.
Degree: Bioscience, 2015, University of Skövde
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11240
► This review has examined the spatial and temporal neural activation of speech comprehension. Six theories on speech comprehension were selected and reviewed. The most…
(more)
▼ This review has examined the spatial and temporal neural activation of speech comprehension. Six theories on speech comprehension were selected and reviewed. The most fundamental structures for speech comprehension are the superior temporal gyrus, the fusiform gyrus, the temporal pole, the temporoparietal junction, and the inferior frontal gyrus. Considering temporal aspects of processes, the N400 ERP effect indicates semantic violations, and the P600 indicates re-evaluation of a word due to ambiguity or syntax error. The dual-route processing model provides the most accurate account of neural correlates and streams of activation necessary for speech comprehension, while also being compatible with both the reviewed studies and the reviewed theories. The integrated theory of language production and comprehension provides a contemporary theory of speech production and comprehension with roots in computational neuroscience, which in conjunction with the dual-route processing model could drive the fields of language and neuroscience even further forward.
Subjects/Keywords: Language; speech comprehension; dual-route processing model; trace model; superior temporal gyrus; inferior frontal gyrus; N400; P600; Neurosciences; Neurovetenskaper
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APA (6th Edition):
Roos, M. (2015). Speech Comprehension : Theoretical approaches and neural correlates. (Thesis). University of Skövde. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11240
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Roos, Magnus. “Speech Comprehension : Theoretical approaches and neural correlates.” 2015. Thesis, University of Skövde. Accessed January 26, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11240.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Roos, Magnus. “Speech Comprehension : Theoretical approaches and neural correlates.” 2015. Web. 26 Jan 2021.
Vancouver:
Roos M. Speech Comprehension : Theoretical approaches and neural correlates. [Internet] [Thesis]. University of Skövde; 2015. [cited 2021 Jan 26].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11240.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Roos M. Speech Comprehension : Theoretical approaches and neural correlates. [Thesis]. University of Skövde; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11240
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Western Ontario
3.
Holloway, Ian Douglas.
Symbolizing Number: fMRI investigations of the semantic, auditory, and visual correlates of Hindu-Arabic numerals.
Degree: 2012, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/711
► Humans are born with a sensitivity to numerical magnitude. In literate cultures, these numerical intuitions are associated with a symbolic notation (e.g..Hindu-Arabic numerals). While a…
(more)
▼ Humans are born with a sensitivity to numerical magnitude. In literate cultures, these numerical intuitions are associated with a symbolic notation (e.g..Hindu-Arabic numerals). While a growing body of neuroscientific research has been conducted to elucidate commonalities between symbolic (e.g. Hinud-Arabic numerals) and non-symbolic (e.g. arrays of objects) representations, relatively little is known about the neural correlates specific to the symbolic processing of numerical magnitude. To address this, I conducted the three fMRI experiments contained within this thesis to characterize the neuroanatomical correlates of the auditory, visual, audiovisual, and semantic processing of numerical symbols.
In Experiment 1, the neural correlates of symbolic and non-symbolic number were contrasted to reveal that the left angular and superior temporal gyri responded specifically to numerals, while the right posterior superior parietal lobe only responded to non-symbolic arrays. Moreover, the right intraparietal sulcus (IPS) was activated by both formats. The results reflect divergent encoding pathways that converge upon a common representation across formats.
In Experiment 2, the neural response to Hindu-Arabic numerals and Chinese numerical ideographs was recorded in individuals who could read both notations and a control group who could read only the numerals. A between-groups contrast revealed semantic processing of ideographs in the right IPS, while asemantic visual processing was found in the left fusiform gyrus. In contrast to the ideographs, the semantic processing of numerals was associated with left IPS activity. The role of these brain regions in the semantic and asemantic representation of numerals is discussed.
In Experiment 3, the neural response of the visual, auditory, and audiovisual processing of numerals and letters was measured. The regions associated with visual and auditory responses to letters and numerals were highly similar. In contrast, the audiovisual response to numerals recruited a region of the right supramarginal gyrus, while the audiovisual letters activated left visual regions. In addition, an effect of congruency in the audiovisual pairs was comparable across numeral-number name pairs and letter-letter name pairs, but absent in letter-speech sound pairs.
Taken together, these three experiments provide new insights into how the brain processes numerical symbols at different levels of description.
Subjects/Keywords: Hindu-Arabic numerals; fMRI; numerical magnitude representation; audiovisual integration; intraparietal sulcus; fusiform gyrus; superior temporal gyrus; Cognitive Neuroscience
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APA ·
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Manager
APA (6th Edition):
Holloway, I. D. (2012). Symbolizing Number: fMRI investigations of the semantic, auditory, and visual correlates of Hindu-Arabic numerals. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/711
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Holloway, Ian Douglas. “Symbolizing Number: fMRI investigations of the semantic, auditory, and visual correlates of Hindu-Arabic numerals.” 2012. Thesis, University of Western Ontario. Accessed January 26, 2021.
https://ir.lib.uwo.ca/etd/711.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Holloway, Ian Douglas. “Symbolizing Number: fMRI investigations of the semantic, auditory, and visual correlates of Hindu-Arabic numerals.” 2012. Web. 26 Jan 2021.
Vancouver:
Holloway ID. Symbolizing Number: fMRI investigations of the semantic, auditory, and visual correlates of Hindu-Arabic numerals. [Internet] [Thesis]. University of Western Ontario; 2012. [cited 2021 Jan 26].
Available from: https://ir.lib.uwo.ca/etd/711.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Holloway ID. Symbolizing Number: fMRI investigations of the semantic, auditory, and visual correlates of Hindu-Arabic numerals. [Thesis]. University of Western Ontario; 2012. Available from: https://ir.lib.uwo.ca/etd/711
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – San Francisco
4.
Hullett, Patrick W.
Functional Organization of Speech Processing Areas and A Systematic Approach to the Cocktail Party Problem.
Degree: Bioengineering, 2013, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/77q5w40n
► The brain is a physical system that can perform intelligent computations. We are interested in nature of those computations to understand how the brain does…
(more)
▼ The brain is a physical system that can perform intelligent computations. We are interested in nature of those computations to understand how the brain does intelligent things. To that end we have focused on two particularly fruitful questions that were tractable given the current state of knowledge and resources: What is the organization of processing in human speech centers? And, how does the brain solve the cocktail party problem?To address the first question, we recorded superior temporal gyrus activity in awake human subjects passively listening to speech stimuli using electrocorticography. The high spatial and temporal resolution of this recording technique combined with maximally informative dimension analysis made it possible to compute high density spectrotemporal receptive field maps in a region of the brain specialized for speech perception. Based on these maps, we found that human superior temporal gyrus has a strong modulotopic organization - a higher order analog of tonotopic organization that has not been previously identified in any human or non-human auditory area. To investigate the mechanisms by which neural systems solve the cocktail party problem, we created animals that are specialists at extracting vocalization information in the face of by noise-rearing rats and testing them behaviorally to show specialization. Through single unit recordings from primary auditory cortex, we identified a subpopulation of neurons that can extract vocalization information in the face of noise. Although the prevalence of these neurons is the same in both groups of animals, neurons from specialized animals extract information at significantly higher rates. Further receptive field analysis will give insight to the underlying mechanism of this ability. This work demonstrates the ability to create animals specialized at solving the cocktail party problem and a method to identify neurons that contribute to this specialization. This approach can be applied to different classes of noise to generate and refine models of cocktail party processing.
Subjects/Keywords: Neurosciences; Cocktail Party Problem; Functional Organization; Modulotopic Organization; Noise-rearing; Superior Temporal Gyrus
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APA (6th Edition):
Hullett, P. W. (2013). Functional Organization of Speech Processing Areas and A Systematic Approach to the Cocktail Party Problem. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/77q5w40n
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hullett, Patrick W. “Functional Organization of Speech Processing Areas and A Systematic Approach to the Cocktail Party Problem.” 2013. Thesis, University of California – San Francisco. Accessed January 26, 2021.
http://www.escholarship.org/uc/item/77q5w40n.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hullett, Patrick W. “Functional Organization of Speech Processing Areas and A Systematic Approach to the Cocktail Party Problem.” 2013. Web. 26 Jan 2021.
Vancouver:
Hullett PW. Functional Organization of Speech Processing Areas and A Systematic Approach to the Cocktail Party Problem. [Internet] [Thesis]. University of California – San Francisco; 2013. [cited 2021 Jan 26].
Available from: http://www.escholarship.org/uc/item/77q5w40n.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hullett PW. Functional Organization of Speech Processing Areas and A Systematic Approach to the Cocktail Party Problem. [Thesis]. University of California – San Francisco; 2013. Available from: http://www.escholarship.org/uc/item/77q5w40n
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Freie Universität Berlin
5.
Hohmann, Anja.
Modulation von Tonwahrnehmung und -erzeugung mit transkranieller
Gleichstromstimulation.
Degree: 2014, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-12795
► Während mittels bildgebender Verfahren ein Netzwerk von Hirnregionen identifiziert werden konnte, das der Wahrnehmung und Wiedergabe von Lauten dient, ist die genaue Funktion einzelner Knoten…
(more)
▼ Während mittels bildgebender Verfahren ein Netzwerk von Hirnregionen
identifiziert werden konnte, das der Wahrnehmung und Wiedergabe von Lauten
dient, ist die genaue Funktion einzelner Knoten innerhalb dieses Netzwerkes
unbekannt. Für die willkürliche Kontrolle der menschlichen Stimme postulieren
wir eine kausale Rolle des
Gyrus temporalis
superior posterior (pSTG) und des
Gyrus frontalis inferior posterior (pIFG) der linken und rechten Hemisphäre.
In dieser Arbeit wird die Funktion dieser Areale durch reversible
Läsionsstudien mithilfe der transkraniellen Gleichstromstimulation (tDCS)
untersucht. Methoden: In zwei Experimenten, bestehend aus je fünf separaten
Stimulationen, erhielten die Probanden je eine kathodische Stimulation über
dem pSTG und dem pIFG jeder Hemisphäre sowie eine Placebostimulation. Im
ersten Experiment sollten die Probanden (n = 10) eine Tonfolge wiedergeben,
wobei die Genauigkeit der Tonwiedergabe nach erfolgter tDCS gemessen wurde. Im
zweiten Experiment hörten die Probanden (n = 15) sich selbst summen. Dieses
Feedback wurde unerwartet in der Tonhöhe verändert. Die Kompensation zum
transponierten Feedback nach Hirnstimulation wurde gemessen und mit Daten von
Amusikern (n = 8), die keine Hirnstimulation erhielten, verglichen. Alle Daten
wurden digital aufgenommen, weiterverarbeitet und ausgewertet. Ergebnisse:
Nach Stimulation über dem linken pIFG und dem rechten pSTG wird die Tonhöhe
einer zu imitierenden Tonfolge weniger exakt wiedergegeben als unter
Placebostimulation. Des Weiteren nehmen alle nicht-amusischen Probanden
ungewollte Veränderungen im Feedback ihrer eigenen Stimme wahr und
kompensieren ohne Stimulation hierfür. Amusiker hingegen zeigen keine Reaktion
auf verändertes Feedback. Reduziert man die neuronale Erregbarkeit in dem
linken pIFG und dem rechten pSTG, kompensieren musikalisch geschulte Probanden
in geringerem Maße als ohne Stimulation. Probanden ohne musikalisches Training
zeigen keinen Einfluss der tDCS auf das Ausmaß der Kompensation. Unabhängig
von musikalischem Training reagieren jedoch alle Probanden nach kathodischer
tDCS über dem rechten pSTG langsamer auf das veränderte Feedback ihrer eigenen
Stimme. Fazit: In dieser Arbeit konnte gezeigt werden, dass sowohl der
Gyrus
frontalis inferior posterior als auch der
Gyrus temporalis
superior posterior
wichtige Knotenpunkte in einem bihemisphäriellen Netzwerk der Stimmkontrolle
sind. Die neuronalen Mechanismen einer effizienten Stimmhöhenregulation sind
zu einem gewissen Maße trainingsabhängig. tDCS ist eine geeignete Methode, die
Lautproduktion zu modulieren und sollte vermehrt in der Therapie von
Sprechstörungen zum Einsatz kommen.
Advisors/Committee Members: w (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: tDCS; brain stimulation; perturbed auditory feedback; pitch production; inferior frontal gyrus; superior temporal gyrus; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
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APA ·
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Manager
APA (6th Edition):
Hohmann, A. (2014). Modulation von Tonwahrnehmung und -erzeugung mit transkranieller
Gleichstromstimulation. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12795
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hohmann, Anja. “Modulation von Tonwahrnehmung und -erzeugung mit transkranieller
Gleichstromstimulation.” 2014. Thesis, Freie Universität Berlin. Accessed January 26, 2021.
http://dx.doi.org/10.17169/refubium-12795.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hohmann, Anja. “Modulation von Tonwahrnehmung und -erzeugung mit transkranieller
Gleichstromstimulation.” 2014. Web. 26 Jan 2021.
Vancouver:
Hohmann A. Modulation von Tonwahrnehmung und -erzeugung mit transkranieller
Gleichstromstimulation. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Jan 26].
Available from: http://dx.doi.org/10.17169/refubium-12795.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hohmann A. Modulation von Tonwahrnehmung und -erzeugung mit transkranieller
Gleichstromstimulation. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-12795
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Vienna
6.
Deutsch, Stephanie.
Das Moralische Dilemma und die neuronalen Korrelate der moralischen Urteilsbildung.
Degree: 2010, University of Vienna
URL: http://othes.univie.ac.at/8452/
► Heute werden zur Erforschung der Hintergründe moralischen Urteilens behaviorale Messmethoden mit Neuroimaging Verfahren (z.B.fMRT) kombiniert. Demgegenüber wurde im Rahmen der vorliegenden Arbeit versucht, die neuronalen…
(more)
▼ Heute werden zur Erforschung der Hintergründe moralischen Urteilens behaviorale Messmethoden mit Neuroimaging Verfahren (z.B.fMRT) kombiniert. Demgegenüber wurde im Rahmen der vorliegenden Arbeit versucht, die neuronalen Korrelate moralischen Urteilens mittels EEG auf Ebene der hirnelektrischen Potenzialschwankungen, die mit Prozessen in den entsprechenden Hirnarealen einhergehen, zu durchleuchten. Im Hinblick auf beteiligte Areale im Zuge der Darbietung moralischer Dilemma Szenarien konnten erwartete Aktivierungsmaxima in Bereichen des medialen frontalen Gyrus, des posterioren cingulären Gyrus, und des superioren temporalen Sulcus im Rahmen der statistischen Analyse nicht bestätigt werden.
Subjects/Keywords: 77.50 Psychophysiologie; 30.03 Methoden und Techniken in den Naturwissenschaften; Elektroenzephalogramm / EEG / Moralisches Urteil / Moralisches Dilemma / frontaler Gyrus / superiorer temporaler Sulcus / cingulärer Gyrus; EEG / electroencephalography / moral dilemma / moral judgment / frontal gyrus / superior temporal sulcus / cingulate gyrus
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APA ·
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APA (6th Edition):
Deutsch, S. (2010). Das Moralische Dilemma und die neuronalen Korrelate der moralischen Urteilsbildung. (Thesis). University of Vienna. Retrieved from http://othes.univie.ac.at/8452/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Deutsch, Stephanie. “Das Moralische Dilemma und die neuronalen Korrelate der moralischen Urteilsbildung.” 2010. Thesis, University of Vienna. Accessed January 26, 2021.
http://othes.univie.ac.at/8452/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Deutsch, Stephanie. “Das Moralische Dilemma und die neuronalen Korrelate der moralischen Urteilsbildung.” 2010. Web. 26 Jan 2021.
Vancouver:
Deutsch S. Das Moralische Dilemma und die neuronalen Korrelate der moralischen Urteilsbildung. [Internet] [Thesis]. University of Vienna; 2010. [cited 2021 Jan 26].
Available from: http://othes.univie.ac.at/8452/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Deutsch S. Das Moralische Dilemma und die neuronalen Korrelate der moralischen Urteilsbildung. [Thesis]. University of Vienna; 2010. Available from: http://othes.univie.ac.at/8452/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
7.
CHAN PEI LING KAREN.
ON THE ROLE OF VOCAL EMOTIONS FOR VERBAL MEMORY:
AN INVESTIGATION OF NEURAL AND PSYCHOPHYSIOLOGICAL MECHANISMS.
Degree: 2012, National University of Singapore
URL: http://scholarbank.nus.edu.sg/handle/10635/34350
Subjects/Keywords: vocal; emotion; prosody; verbal; memory; superior temporal gyrus; sadness; heart rate; cardiac.
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APA (6th Edition):
KAREN, C. P. L. (2012). ON THE ROLE OF VOCAL EMOTIONS FOR VERBAL MEMORY:
AN INVESTIGATION OF NEURAL AND PSYCHOPHYSIOLOGICAL MECHANISMS. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/34350
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
KAREN, CHAN PEI LING. “ON THE ROLE OF VOCAL EMOTIONS FOR VERBAL MEMORY:
AN INVESTIGATION OF NEURAL AND PSYCHOPHYSIOLOGICAL MECHANISMS.” 2012. Thesis, National University of Singapore. Accessed January 26, 2021.
http://scholarbank.nus.edu.sg/handle/10635/34350.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
KAREN, CHAN PEI LING. “ON THE ROLE OF VOCAL EMOTIONS FOR VERBAL MEMORY:
AN INVESTIGATION OF NEURAL AND PSYCHOPHYSIOLOGICAL MECHANISMS.” 2012. Web. 26 Jan 2021.
Vancouver:
KAREN CPL. ON THE ROLE OF VOCAL EMOTIONS FOR VERBAL MEMORY:
AN INVESTIGATION OF NEURAL AND PSYCHOPHYSIOLOGICAL MECHANISMS. [Internet] [Thesis]. National University of Singapore; 2012. [cited 2021 Jan 26].
Available from: http://scholarbank.nus.edu.sg/handle/10635/34350.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
KAREN CPL. ON THE ROLE OF VOCAL EMOTIONS FOR VERBAL MEMORY:
AN INVESTIGATION OF NEURAL AND PSYCHOPHYSIOLOGICAL MECHANISMS. [Thesis]. National University of Singapore; 2012. Available from: http://scholarbank.nus.edu.sg/handle/10635/34350
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
8.
Sikka, Ritu.
An fMRI comparison between younger and older adults of neural activity associated with recognition of familiar melodies
.
Degree: Neuroscience Studies, 2013, Queens University
URL: http://hdl.handle.net/1974/8284
► We investigated age-related differences in neural activation associated with recognition of familiar melodies, a process that requires retrieval from musical semantic memory and leads to…
(more)
▼ We investigated age-related differences in neural activation associated with recognition of familiar melodies, a process that requires retrieval from musical semantic memory and leads to a feeling of familiarity. We used sparse sampling fMRI to determine the neural correlates of melody processing and familiarity by comparing activation when listening to melodies versus signal-correlated noise, and to familiar versus unfamiliar melodies, respectively. Overall, activity in the bilateral superior temporal gyrus correlated well with melody processing. Familiarity was associated with several frontal regions (bilateral inferior frontal gyrus, superior frontal gyrus, and precentral gyrus; left insular cortex), right superior temporal gyrus; left supramarginal gyrus and cingulate gyrus; bilateral putamen and thalamus; cerebellum and brainstem. No significant differences were found between younger and older adults for either melody processing or familiarity based activation. Assessment of familiarity-related group differences using less stringent criteria identified plausible areas; greater activation was seen bilaterally in the superior temporal gyrus in younger adults and in some left parietal regions in older adults. This study adds to the knowledge of musical semantic memory with results based on a large sample (N = 40) that includes older adults. Our findings for activation associated with melody processing and familiarity support some, but not all, previous results of related studies. We were unable to find conclusive evidence of age-related differences in neural correlates of musical semantic memory, while also being the first study (to the best of our knowledge) to search for these differences.
Subjects/Keywords: musical semantic memory
;
sparse sampling
;
fMRI
;
musical memory
;
melody processing
;
superior temporal gyrus
;
neural basis of musical memory
;
inferior frontal gyrus
;
effects of aging on musical semantic memory
;
musical lexicon
;
aging
;
familiarity
;
familiar melodies
;
semantic memory
;
recognition
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APA (6th Edition):
Sikka, R. (2013). An fMRI comparison between younger and older adults of neural activity associated with recognition of familiar melodies
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8284
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sikka, Ritu. “An fMRI comparison between younger and older adults of neural activity associated with recognition of familiar melodies
.” 2013. Thesis, Queens University. Accessed January 26, 2021.
http://hdl.handle.net/1974/8284.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sikka, Ritu. “An fMRI comparison between younger and older adults of neural activity associated with recognition of familiar melodies
.” 2013. Web. 26 Jan 2021.
Vancouver:
Sikka R. An fMRI comparison between younger and older adults of neural activity associated with recognition of familiar melodies
. [Internet] [Thesis]. Queens University; 2013. [cited 2021 Jan 26].
Available from: http://hdl.handle.net/1974/8284.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sikka R. An fMRI comparison between younger and older adults of neural activity associated with recognition of familiar melodies
. [Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/8284
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
9.
Peret, Angelique.
Rôle des récepteurs Kaïnate dans la physiopathologie de l'épilepsie du lobe temporal : Role of kainate receptors in the pathophysiology of temporal lobe epilepsy.
Degree: Docteur es, Neurosciences, 2014, Aix Marseille Université
URL: http://www.theses.fr/2014AIXM4068
► Le kaïnate, est une puissante neurotoxine connue pour induire des convulsions qui rappellent celles trouvées chez les patients atteints d'épilepsie du lobe temporal (ELT). Cependant,…
(more)
▼ Le kaïnate, est une puissante neurotoxine connue pour induire des convulsions qui rappellent celles trouvées chez les patients atteints d'épilepsie du lobe temporal (ELT). Cependant, le rôle des récepteurs kaïnate activés par le glutamate endogène dans l'ELT n'est pas encore connu. Chez les patients atteints d'ELT et dans les modèles animaux, le tissu neuronal subit une réorganisation majeure. Ce phénomène est particulièrement bien documenté dans le gyrus denté où les axones des cellules granulaires, bourgeonnent pour former un circuit récurrent excitateur aberrant. L'équipe a montré que ces synapses récurrentes moussues nouvellement formées sont aberrantes dans leurs modes de fonctionnement. En effet, en plus des synapses opérant via des récepteurs glutamatergiques de type AMPA présentes en conditions physiologiques, la moitié des synapses aberrantes fonctionnent via des récepteurs de type kaïnate. Les évènements générés par les récepteurs kaïnate ont une cinétique lente, leur permettant de s'intégrer dans une fenêtre temporelle anormalement étendue engendrant un taux de décharge soutenu et fortement rythmique des cellules du gyrus denté de rats épileptiques. L'objectif de mon travail de thèse a été d'étudier l'implication des récepteurs kaïnate dans les activités épileptiques de l'hippocampe. En utilisant différents modèles d'ELT nous avons pu observer que l'absence de ces récepteurs induit une forte diminution de la fréquence des activités épileptiformes dans le gyrus denté in vitro mais également in vivo. Cette étude démontre que les récepteurs kaïnate contenant la sous-unité GluK2 contribuent à la genèse des crises.
Kainate is a potent neurotoxin known to induce acute seizures. However, whether kainate receptors play any role in the pathophysiology of temporal lobe epilepsy (TLE) is not yet known. In animal models of chronic epilepsy, as in human TLE, the hippocampus displays major network reorganization. In particular, sprouting of hippocampal mossy fibers leads to the formation of powerful recurrent excitatory circuits among dentate granule cells, which partly accounts for the enhanced ability of the hippocampus to generate epileptiform activity in human patients and animal models of TLE. At the aberrant recurrent excitatory synapses, mossy fiber inputs impinging on dentate granule cells operate mostly via ectopic kainate receptors and drive synaptic events with abnormal long lasting kinetics not present in naïve conditions. The goal of this work was to explore the pathophysiological implications of kainate receptors in generation of recurrent seizure in TLE through the use of kainate receptors subunit deficient mice and selected pharmacological agents. In an animal model of TLE, we observed a strong reduction of both interictal and ictal activities in the dentate gyrus in vitro and in vivo, in mice lacking the GluK2 subunit, and through the application of a pharmacological agent inhibiting GluK2/GluK5 receptors. Therefore, we demonstrate that aberrant GluK2-containing kainate receptors contribute to…
Advisors/Committee Members: Crepel, Valérie (thesis director).
Subjects/Keywords: Récepteurs kaïnate; Épilepsie du lobe temporal; Gyrus denté; Kainate receptor; Temporal lobe epilepsy; Dentate gyrus; 612
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APA (6th Edition):
Peret, A. (2014). Rôle des récepteurs Kaïnate dans la physiopathologie de l'épilepsie du lobe temporal : Role of kainate receptors in the pathophysiology of temporal lobe epilepsy. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2014AIXM4068
Chicago Manual of Style (16th Edition):
Peret, Angelique. “Rôle des récepteurs Kaïnate dans la physiopathologie de l'épilepsie du lobe temporal : Role of kainate receptors in the pathophysiology of temporal lobe epilepsy.” 2014. Doctoral Dissertation, Aix Marseille Université. Accessed January 26, 2021.
http://www.theses.fr/2014AIXM4068.
MLA Handbook (7th Edition):
Peret, Angelique. “Rôle des récepteurs Kaïnate dans la physiopathologie de l'épilepsie du lobe temporal : Role of kainate receptors in the pathophysiology of temporal lobe epilepsy.” 2014. Web. 26 Jan 2021.
Vancouver:
Peret A. Rôle des récepteurs Kaïnate dans la physiopathologie de l'épilepsie du lobe temporal : Role of kainate receptors in the pathophysiology of temporal lobe epilepsy. [Internet] [Doctoral dissertation]. Aix Marseille Université 2014. [cited 2021 Jan 26].
Available from: http://www.theses.fr/2014AIXM4068.
Council of Science Editors:
Peret A. Rôle des récepteurs Kaïnate dans la physiopathologie de l'épilepsie du lobe temporal : Role of kainate receptors in the pathophysiology of temporal lobe epilepsy. [Doctoral Dissertation]. Aix Marseille Université 2014. Available from: http://www.theses.fr/2014AIXM4068
Brunel University
10.
Shaw, Lynda Joan.
Emotional processing of natural visual images in brief exposures and compound stimuli : fMRI and behavioural studies.
Degree: PhD, 2009, Brunel University
URL: http://bura.brunel.ac.uk/handle/2438/3203
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557697
► Can the brain register the emotional valence of brief exposures of complex natural stimuli under conditions of forward and backward masking, and under conditions of…
(more)
▼ Can the brain register the emotional valence of brief exposures of complex natural stimuli under conditions of forward and backward masking, and under conditions of attentional competition between foveal and peripheral stimuli? To address this question, three experiments were conducted. The first, a behavioural experiment, measured subjective valence of response (pleasant vs unpleasant) to test the perception of the valence of natural images in brief, masked exposures in a forward and backward masking paradigm. Images were chosen from the International Affective Picture System (IAPS) series. After correction for response bias, responses to the majority of target stimuli were concordant with the IAPS ratings at better than chance, even when the presence of the target was undetected. Using functional magnetic resonance imaging (fMRI), the effects of IAPS valence and stimulus category were objectively measured on nine regions of interest (ROIs) using the same strict temporal restrictions in a similar masking design. Evidence of affective processing close to or below conscious threshold was apparent in some of the ROIs. To further this line of enquiry, a second fMRI experiment mapping the same ROIs and using the same stimuli were presented in a foveal (‘attended’) peripheral (‘to-be-ignored’) paradigm (small image superimposed in the centre of a large image of the same category, but opposite valence) to investigate spatial parameters and limitations of attention. Results are interpreted as showing both valence and category specific effects of ‘to-be-ignored’ images in the periphery. These results are discussed in light of theories of the limitations of attentional capacity and the speed in which we process natural images, providing new evidence of the breadth of variety in the types of affective visual stimuli we are able to process close to the threshold of conscious perception.
Subjects/Keywords: 612.8; Amygdala; Anterior Cingulate Cortex; medial Prefrontal Cortex; Dorsolateral Prefrontal Cortex; Orbitofrontal Cortex; Parahippocampus; Fusiform Gyrus; Insula; Superior Temporal Gyrus; consciousness; attention; masking; fMRI
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APA ·
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APA (6th Edition):
Shaw, L. J. (2009). Emotional processing of natural visual images in brief exposures and compound stimuli : fMRI and behavioural studies. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/3203 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557697
Chicago Manual of Style (16th Edition):
Shaw, Lynda Joan. “Emotional processing of natural visual images in brief exposures and compound stimuli : fMRI and behavioural studies.” 2009. Doctoral Dissertation, Brunel University. Accessed January 26, 2021.
http://bura.brunel.ac.uk/handle/2438/3203 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557697.
MLA Handbook (7th Edition):
Shaw, Lynda Joan. “Emotional processing of natural visual images in brief exposures and compound stimuli : fMRI and behavioural studies.” 2009. Web. 26 Jan 2021.
Vancouver:
Shaw LJ. Emotional processing of natural visual images in brief exposures and compound stimuli : fMRI and behavioural studies. [Internet] [Doctoral dissertation]. Brunel University; 2009. [cited 2021 Jan 26].
Available from: http://bura.brunel.ac.uk/handle/2438/3203 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557697.
Council of Science Editors:
Shaw LJ. Emotional processing of natural visual images in brief exposures and compound stimuli : fMRI and behavioural studies. [Doctoral Dissertation]. Brunel University; 2009. Available from: http://bura.brunel.ac.uk/handle/2438/3203 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557697
University of Vienna
11.
Zapletal, Jutta.
Funktionelle Neuroanatomie des Benennens (Picture Naming) von Tätigkeiten und Objekten.
Degree: 2010, University of Vienna
URL: http://othes.univie.ac.at/11447/
► Einführung In der vorliegenden Studie wurde untersucht, ob beim Benennen von Objektbildern und Handlungsbildern ein funktionell neuroanatomischer Unterschied besteht. Methode Das verwendete Stimulusmaterial bestand insgesamt…
(more)
▼ Einführung
In der vorliegenden Studie wurde untersucht, ob beim Benennen von Objektbildern und Handlungsbildern ein funktionell neuroanatomischer Unterschied besteht.
Methode
Das verwendete Stimulusmaterial bestand insgesamt aus 200 Bildern von Objekten und Tätigkeiten, welche den Versuchspersonen via Computerbildschirm präsentiert wurden. Die Registrierung der neuronalen Aktivität erfolgte mittels ERP. Die Ermittlung der Antwortlatenzen erfolgte durch Mittelwertsvergleiche, sowie durch die Anwendung von Varianzanalysen. Die ERP Daten wurden mit sLORETA und SnPM ausgewertet.
Ergebnisse
Mit der vorliegenden Untersuchung konnte die Theorie zur Bilderverarbeitung erweitert werden. Bilder von Objekten werden schneller benannt als Bilder von Tätigkeiten. Gender-Unterschiede in der Benennlatenzen konnten nicht gefunden werden. Das Resultat der kortikalen Prozesse verdeutlicht, dass es keinen Unterschied in der Aktivitätslokalisation beim Benennen von Bildern mit Tätigkeit und Objekte gibt. Die Produktion von Bildern mit Tätigkeiten und Objekten findet nicht ausschließlich im Temporallappen statt, sondern basiert auf einem gemeinsamen neuronalen Netzwerk, das sich aus den kortikalen Strukturen im Frontal - und Temporallappen zusammensetzt. Die ermittelten Ergebnisse durch SnPM lassen nicht den Schluss zu, dass die beobachteten kortikalen Aktivierungsdifferenzen eindeutig einer Bedingung zugeordnet werden können
Subjects/Keywords: 77.50 Psychophysiologie; 77.40 Wahrnehmungspsychologie; Elektroenzephalogramm / Picture Naming von Objekten und Tätigkeiten / kortikale Aktivierung / Gyrus temporalis inferior / Gyrus temporalis medius / Gyrus temporalis superior
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APA ·
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APA (6th Edition):
Zapletal, J. (2010). Funktionelle Neuroanatomie des Benennens (Picture Naming) von Tätigkeiten und Objekten. (Thesis). University of Vienna. Retrieved from http://othes.univie.ac.at/11447/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zapletal, Jutta. “Funktionelle Neuroanatomie des Benennens (Picture Naming) von Tätigkeiten und Objekten.” 2010. Thesis, University of Vienna. Accessed January 26, 2021.
http://othes.univie.ac.at/11447/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zapletal, Jutta. “Funktionelle Neuroanatomie des Benennens (Picture Naming) von Tätigkeiten und Objekten.” 2010. Web. 26 Jan 2021.
Vancouver:
Zapletal J. Funktionelle Neuroanatomie des Benennens (Picture Naming) von Tätigkeiten und Objekten. [Internet] [Thesis]. University of Vienna; 2010. [cited 2021 Jan 26].
Available from: http://othes.univie.ac.at/11447/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zapletal J. Funktionelle Neuroanatomie des Benennens (Picture Naming) von Tätigkeiten und Objekten. [Thesis]. University of Vienna; 2010. Available from: http://othes.univie.ac.at/11447/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
12.
Artinian, Julien.
Propriétés de codage des cellules granulaires du gyrus denté dans un modèle d' épilepsie du lobe temporal : Coding properties of dentale granule cells in a model of temporal lobe epilepsy.
Degree: Docteur es, Neurosciences, 2012, Aix Marseille Université
URL: http://www.theses.fr/2012AIXM4076
► Le gyrus denté occupe une position clé au sein du lobe temporal des mammifères en constituant le point de contrôle entre le système néocortical et…
(more)
▼ Le gyrus denté occupe une position clé au sein du lobe temporal des mammifères en constituant le point de contrôle entre le système néocortical et le système hippocampique. Considéré comme la porte de l'hippocampe, le gyrus denté filtre les activités excitatrices en provenance du cortex entorhinal grâce à la décharge éparse des cellules granulaires. Ce type de codage neuronal lui confère également un rôle déterminant dans les mécanismes de l'apprentissage et de la mémoire lors de la distinction d'évènements similaires mais différents, en permettant la décorrélation des patrons d'activité corticale. Grâce à un ensemble de propriétés structurales et fonctionnelles, les cellules granulaires du gyrus denté génèrent des évènements synaptiques extrêmement rapides restreignant leur fenêtre temporelle d'intégration et leur permettant de jouer le rôle de détecteurs de coïncidence. Au cours d'une épilepsie du lobe temporal (ELT), l'hippocampe présente d'importantes altérations de codage neuronal qui pourraient participer aux troubles cognitifs décrits chez les patients et les modèles animaux. Dans ces conditions pathologiques, les axones des cellules granulaires du gyrus denté (les fibres moussues) bourgeonnent et établissent des synapses aberrantes au niveau d'autres cellules granulaires, créant ainsi un puissant réseau excitateur récurrent. Ces fibres moussues récurrentes convertissent la nature de la transmission glutamatergique car elles opèrent via des récepteurs kaïnate générant des potentiels post-synaptiques à cinétique lente, absents en condition contrôle.
The dentate gyrus plays a major role at the gate of the hippocampus, filtering incoming information from the entorhinal cortex. A fundamental coding property of dentate granule cells (DGCs) is their sparse firing. Indeed, they behave as a coincidence detector due to the fast kinetics of excitatory synaptic events restricting integration of afferent inputs to a narrow time window. In temporal lobe epilepsy (TLE), the hippocampus displays important coding alterations that may play a role in cognitive impairments described in patients and animal models. However, the cellular mechanisms remain poorly understood. In animal models of TLE and human patients, neuronal tissue undergoes major reorganization; some neurons die whereas others, which are severed in their inputs or outputs, sprout and form novel aberrant connections. This phenomenon, called reactive plasticity, is well documented in the dentate gyrus where DGC axons (the mossy fibres) sprout and create a powerful excitatory network between DGCs. We recently showed that in addition to the axonal rewiring, recurrent mossy fibres convert the nature of glutamatergic transmission in the dentate gyrus because they operate via long-lasting kainate receptor (KAR)-mediated EPSPs (EPSPKA) not present in the naive condition.
Advisors/Committee Members: Crepel, Valérie (thesis director).
Subjects/Keywords: Gyrus denté; Cellules granulaires; Codage neuronal; Récepteurs kaïnate; Courant sodique persistant; Épilepsie du lobe temporal; Dentate gyrus; Dentate granule cells; Neural coding; Kaïnate receptors; Persistent sodium current; Temporal lobe epilepsy
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APA ·
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APA (6th Edition):
Artinian, J. (2012). Propriétés de codage des cellules granulaires du gyrus denté dans un modèle d' épilepsie du lobe temporal : Coding properties of dentale granule cells in a model of temporal lobe epilepsy. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2012AIXM4076
Chicago Manual of Style (16th Edition):
Artinian, Julien. “Propriétés de codage des cellules granulaires du gyrus denté dans un modèle d' épilepsie du lobe temporal : Coding properties of dentale granule cells in a model of temporal lobe epilepsy.” 2012. Doctoral Dissertation, Aix Marseille Université. Accessed January 26, 2021.
http://www.theses.fr/2012AIXM4076.
MLA Handbook (7th Edition):
Artinian, Julien. “Propriétés de codage des cellules granulaires du gyrus denté dans un modèle d' épilepsie du lobe temporal : Coding properties of dentale granule cells in a model of temporal lobe epilepsy.” 2012. Web. 26 Jan 2021.
Vancouver:
Artinian J. Propriétés de codage des cellules granulaires du gyrus denté dans un modèle d' épilepsie du lobe temporal : Coding properties of dentale granule cells in a model of temporal lobe epilepsy. [Internet] [Doctoral dissertation]. Aix Marseille Université 2012. [cited 2021 Jan 26].
Available from: http://www.theses.fr/2012AIXM4076.
Council of Science Editors:
Artinian J. Propriétés de codage des cellules granulaires du gyrus denté dans un modèle d' épilepsie du lobe temporal : Coding properties of dentale granule cells in a model of temporal lobe epilepsy. [Doctoral Dissertation]. Aix Marseille Université 2012. Available from: http://www.theses.fr/2012AIXM4076
13.
Soussi, Rabia.
Système supramammillaro- hippocampique : propriétés anatomiques et neurochimiques; plasticité dans un modèle d'épilepsie du lobe temporal : Mechanical study of stone columns loaded by rigid footings.
Degree: Docteur es, Neurosciences, 2011, Aix-Marseille 2
URL: http://www.theses.fr/2011AIX20699
► Les épilepsies mésiales du lobe temporal (ELTM) sont parmi les formes les plus fréquentes d’épilepsies partielles pharmaco-résistantes de l’adulte et l’enfant. Dans ces épilepsies les…
(more)
▼ Les épilepsies mésiales du lobe temporal (ELTM) sont parmi les formes les plus fréquentes d’épilepsies partielles pharmaco-résistantes de l’adulte et l’enfant. Dans ces épilepsies les études électrocliniques et expérimentales indiquent que la zone épileptogène, qui désigne un ensemble de neurones nécessaire et suffisant à l’organisation d’une décharge anormale, ne peut être réduite à la seule formation hippocampique (FH) et impliquerait une réorganisation mettant en jeu plusieurs structures au sein du système limbique. Dans ce travail de thèse, nous nous sommes intéressés à la connectivité structurale entre le noyau supramammillaire (SuM) et la FH chez le rat dans le but de déterminer l’identité neurochimique de la voie de projection supramammillaro-hippocampique qui n’avait pas été clairement identifiée et, vérifier l’hypothèse d’une éventuelle réorganisation de cette voie de projection dans le modèle d’ELTM induit par l’injection intrapéritonéale de pilocarpine chez le rat. Chez les rats naïfs, nous mettons en évidence deux voies de projection distinctes. La première a pour origine les neurones localisés dans la partie latérale du SUM (SuML) qui innervent le champ CA2-CA3a et principalement la couche supragranulaire du gyrus dentelé dorsal. Cette voie est essentiellement ipsi-latérale et a la caractéristique de présenter un profil neurochimique unique, à la fois GABAergique et glutamatergique. La seconde voie de projection a pour origine les neurones localisés dans la partie plus postérieure et médiane du SuM (SuMM) qui innervent la région CA2-CA3a et la région ventrale du gyrus dentelé exclusivement ; cette voie est purement glutamatergique. Chez les rats traités à la pilocarpine, nos résultats montrent une réorganisation structurale des afférences des noyaux SuML et SuMM qui innervent le gyrus dentelé. Cette réorganisation est caractérisée par une distribution aberrante et une augmentation du nombre de fibres et terminaisons axonales en provenance des noyaux SuML et SuMM dans la couche moléculaire interne du gyrus dentelé. Cette réorganisation commence à la fin de la période de latence, et évolue pendant l’épilepsie induite par la pilocarpine. Avec ce travail, nous montrons pour la première fois : 1) l’hétérogénéité à la fois anatomique et neurochimique des voies de projection supramammillaro-hippocampiques ; 2) dans le gyrus dentelé des animaux traités à la pilocarpine, une réorganisation structurale d’origine extra-hippocampique, en provenance des noyaux SuML et SuMM. Cette connectivité aberrante pourrait contribuer avec la réorganisation des circuits intrinsèques de l’hippocampe à l’émergence des premières crises spontanées et à l’installation de l’épilepsie.
Mesial temporal lobe epilepsies (MTLE) are among the most common forms of pharmacoresistant partial epilepsies in adults and children. In these epilepsies, spontaneous seizures likely originate from a multi-structural epileptogenic zone including several structures of the limbic system connected to the hippocampal formation (HF). In this thesis, we…
Advisors/Committee Members: Esclapez, Monique (thesis director).
Subjects/Keywords: Épilepsie mésiale du lobe temporal; Pilocarpine; Gyrus dentelé; Rat; Noyau supramammillaire; Connectivité; Réorganisation; Mesial temporal lobe epilepsy; Pilocarpine; Dentate gyrus; Rat; Supramammillary nucleus; Connectivity; Axonal reorganization
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APA ·
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CSE |
Export
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APA (6th Edition):
Soussi, R. (2011). Système supramammillaro- hippocampique : propriétés anatomiques et neurochimiques; plasticité dans un modèle d'épilepsie du lobe temporal : Mechanical study of stone columns loaded by rigid footings. (Doctoral Dissertation). Aix-Marseille 2. Retrieved from http://www.theses.fr/2011AIX20699
Chicago Manual of Style (16th Edition):
Soussi, Rabia. “Système supramammillaro- hippocampique : propriétés anatomiques et neurochimiques; plasticité dans un modèle d'épilepsie du lobe temporal : Mechanical study of stone columns loaded by rigid footings.” 2011. Doctoral Dissertation, Aix-Marseille 2. Accessed January 26, 2021.
http://www.theses.fr/2011AIX20699.
MLA Handbook (7th Edition):
Soussi, Rabia. “Système supramammillaro- hippocampique : propriétés anatomiques et neurochimiques; plasticité dans un modèle d'épilepsie du lobe temporal : Mechanical study of stone columns loaded by rigid footings.” 2011. Web. 26 Jan 2021.
Vancouver:
Soussi R. Système supramammillaro- hippocampique : propriétés anatomiques et neurochimiques; plasticité dans un modèle d'épilepsie du lobe temporal : Mechanical study of stone columns loaded by rigid footings. [Internet] [Doctoral dissertation]. Aix-Marseille 2; 2011. [cited 2021 Jan 26].
Available from: http://www.theses.fr/2011AIX20699.
Council of Science Editors:
Soussi R. Système supramammillaro- hippocampique : propriétés anatomiques et neurochimiques; plasticité dans un modèle d'épilepsie du lobe temporal : Mechanical study of stone columns loaded by rigid footings. [Doctoral Dissertation]. Aix-Marseille 2; 2011. Available from: http://www.theses.fr/2011AIX20699
14.
Ouedraogo, Wendpagnagde david.
Impact de l'oscillation lente corticale sur l'activité des cellules granulaires du gyrus denté dans un modèle animal d'épilepsie du lobe temporal : Experimental study and multiscale modeling of tissue growth in a perfusion bioreactor : Application to bone tissue engineering.
Degree: Docteur es, Neurosciences, 2013, Aix Marseille Université
URL: http://www.theses.fr/2013AIXM4047
► En plus des crises, les patients atteints d'épilepsie du lobe temporale (ELT) souffrent de déficits cognitifs tels que des troubles de l'apprentissage et de la…
(more)
▼ En plus des crises, les patients atteints d'épilepsie du lobe temporale (ELT) souffrent de déficits cognitifs tels que des troubles de l'apprentissage et de la mémoire épisodique. La formation de la mémoire épisodique nécessite des interactions entre le cortex et l'hippocampe pendant le sommeil. Ces interactions sont orchestrées par l'oscillation lente qui est générée dans le réseau thalamocortical. L'oscillation lente se propage dans d'autres structures sous corticales mais l'hippocampe semble être moins influencé. Cela pourrait être du à la fonction de filtre du gyrus denté. Dans l'ELT, le gyrus denté subit une réorganisation structurelle et fonctionnelle qui pourrait altérer sa fonction de filtre et aussi modifier la propagation d'activités épileptiformes du cortex vers l'hippocampe. Cependant, la propagation de rythmes physiologiques du cortex vers le réseau hippocampique pendant l'épileptogenèse a été peu étudié. Ce travail de thèse a eu pour but d'étudier l'influence des oscillations lentes corticales sur le potentiel de membrane et la décharge des cellules granulaires du gyrus denté dans un modèle d'ELT sous anesthésie. Nos résultats montrent une augmentation de la modulation du potentiel de membrane et ainsi que de la décharge des cellules granulaires du gyrus par l'oscillation lente corticale pendant l'épileptogenèse. Les changements qui s'opèrent dans le gyrus denté pendant l'épileptogenèse le rendraient plus permissif aux informations en provenance du cortex facilitant ainsi la propagation des oscillations lentes du cortex vers l'hippocampe.
In addition to seizures, patients with temporal Lobe Epilepsy (TLE) suffer from cognitive deficits such as learning and episodic memory impairment. The functional interactions between the cortex and the hippocampus notably during sleep are thought to be important for episodic memory formation. These interactions are orchestrated by the slow oscillation which is generated in thalamo-cortical networks. The slow oscillation is not confined to thalamo-neocortical networks but propagates to other subcortical structures but the hippocampus seems however less strongly influenced by the widespread propagation of the slow oscillation. This could result from the gate function of the dentate gyrus. In TLE, the dentate gyrus is associated with profound structural and functional network alterations which can alter the propagation of pathological activities such as epileptiform discharges from the cortex to the hippocampus. However, whether and how epilepsy modifies the impact of physiological activities on hippocampal networks remains to be investigated. This work was designed to study the influence of slow cortical oscillations on the membrane potential and discharge of granule cells in the dentate gyrus in an animal model of TLE. Our results show an increase in the modulation of membrane potential and as well as the discharge of granule cells in the dentate gyrus by the cortical slow oscillation during epileptogenesis. The changes that occur in the dentate gyrus during…
Advisors/Committee Members: Crepel, Valérie (thesis director), Epsztein, Jérôme (thesis director).
Subjects/Keywords: Sommeil; Oscillations lentes; Gyrus denté; In vivo; Épilepsie du lobe temporal; Sleep; Slow oscillations; Dentate gyrus; In vivo; Temporal lobe epilepsy; 612
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APA (6th Edition):
Ouedraogo, W. d. (2013). Impact de l'oscillation lente corticale sur l'activité des cellules granulaires du gyrus denté dans un modèle animal d'épilepsie du lobe temporal : Experimental study and multiscale modeling of tissue growth in a perfusion bioreactor : Application to bone tissue engineering. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2013AIXM4047
Chicago Manual of Style (16th Edition):
Ouedraogo, Wendpagnagde david. “Impact de l'oscillation lente corticale sur l'activité des cellules granulaires du gyrus denté dans un modèle animal d'épilepsie du lobe temporal : Experimental study and multiscale modeling of tissue growth in a perfusion bioreactor : Application to bone tissue engineering.” 2013. Doctoral Dissertation, Aix Marseille Université. Accessed January 26, 2021.
http://www.theses.fr/2013AIXM4047.
MLA Handbook (7th Edition):
Ouedraogo, Wendpagnagde david. “Impact de l'oscillation lente corticale sur l'activité des cellules granulaires du gyrus denté dans un modèle animal d'épilepsie du lobe temporal : Experimental study and multiscale modeling of tissue growth in a perfusion bioreactor : Application to bone tissue engineering.” 2013. Web. 26 Jan 2021.
Vancouver:
Ouedraogo Wd. Impact de l'oscillation lente corticale sur l'activité des cellules granulaires du gyrus denté dans un modèle animal d'épilepsie du lobe temporal : Experimental study and multiscale modeling of tissue growth in a perfusion bioreactor : Application to bone tissue engineering. [Internet] [Doctoral dissertation]. Aix Marseille Université 2013. [cited 2021 Jan 26].
Available from: http://www.theses.fr/2013AIXM4047.
Council of Science Editors:
Ouedraogo Wd. Impact de l'oscillation lente corticale sur l'activité des cellules granulaires du gyrus denté dans un modèle animal d'épilepsie du lobe temporal : Experimental study and multiscale modeling of tissue growth in a perfusion bioreactor : Application to bone tissue engineering. [Doctoral Dissertation]. Aix Marseille Université 2013. Available from: http://www.theses.fr/2013AIXM4047
University of Cambridge
15.
Kent, Brianne A.
Disambiguating the similar : investigating pattern separation in medial temporal lobe structures using rodent models.
Degree: PhD, 2015, University of Cambridge
URL: https://doi.org/10.17863/CAM.16474
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683712
► This dissertation investigates the mechanisms underlying pattern separation, using rodent models and behavioural tasks that assess the use of representations for similar stimuli. Pattern separation…
(more)
▼ This dissertation investigates the mechanisms underlying pattern separation, using rodent models and behavioural tasks that assess the use of representations for similar stimuli. Pattern separation is a theoretical mechanism involving the transformation of inputs into output representations that are less correlated to each other. Because of this orthogonalizing process, similar experiences are stored as discrete non-overlapping representations. Studying pattern separation emphasizes the important but often overlooked fact that successful memory involves more than just remembering events over a period of time, but also differentiating between similar memories. Through a series of experiments this dissertation adds support to the literature that the dentate gyrus (DG) subregion of the hippocampus is important for pattern separation when encoding spatial and contextual inputs. Using the Spontaneous Location Recognition (SLR) task it is shown the brain-derived neurotrophic factor (BDNF) can improve performance by acting via N-methyl-D-aspartate (NMDA) glutamate receptors in the DG and adult-born hippocampal neurons. Manipulating the level of neurogenesis by inhibiting Wnt signalling or by administering acyl-ghrelin systemically is shown to impair and enhance performance on SLR, respectively. Using a novel exposure paradigm in combination with SLR, it is demonstrated for the first time that the relationship between pattern separation and neurogenesis may be reciprocal, such that inhibiting neurogenesis impairs pattern separation, enhancing neurogenesis improves pattern separation, and performing pattern separation enhances the production or survival of adult-born hippocampal neurons. Finally, it is shown that the TgTauP301L mouse model of dementia exhibits spatial and object recognition memory impairments once aged, recapitulating a dementia-like phenotype. Understanding the mechanisms that contribute to effective pattern separation may help elucidate the processes underlying the memory impairment experienced by AD patients. This dissertation concludes with a critical discussion about whether pattern separation can be studied using behavioural paradigms.
Subjects/Keywords: 616.8; Psychology; pattern separation; temporal lobe; dentate gyrus; hippocampus; spontaneous location recognition
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Kent, B. A. (2015). Disambiguating the similar : investigating pattern separation in medial temporal lobe structures using rodent models. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.16474 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683712
Chicago Manual of Style (16th Edition):
Kent, Brianne A. “Disambiguating the similar : investigating pattern separation in medial temporal lobe structures using rodent models.” 2015. Doctoral Dissertation, University of Cambridge. Accessed January 26, 2021.
https://doi.org/10.17863/CAM.16474 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683712.
MLA Handbook (7th Edition):
Kent, Brianne A. “Disambiguating the similar : investigating pattern separation in medial temporal lobe structures using rodent models.” 2015. Web. 26 Jan 2021.
Vancouver:
Kent BA. Disambiguating the similar : investigating pattern separation in medial temporal lobe structures using rodent models. [Internet] [Doctoral dissertation]. University of Cambridge; 2015. [cited 2021 Jan 26].
Available from: https://doi.org/10.17863/CAM.16474 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683712.
Council of Science Editors:
Kent BA. Disambiguating the similar : investigating pattern separation in medial temporal lobe structures using rodent models. [Doctoral Dissertation]. University of Cambridge; 2015. Available from: https://doi.org/10.17863/CAM.16474 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683712
University of Cincinnati
16.
Rolle, Isaiah J.
Threshold for Hippocampal Dentate Granule Cell Mediated
Epileptogenesis.
Degree: PhD, Medicine: Neuroscience/Medical Science Scholars
Interdisciplinary, 2015, University of Cincinnati
URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448873759
► Patients with temporal lobe epilepsy are treated with anticonvulsant drugs that neither prevent nor cure the disease. The development of true anti-epileptogenic therapies will require…
(more)
▼ Patients with
temporal lobe epilepsy are treated with
anticonvulsant drugs that neither prevent nor cure the disease. The
development of true anti-epileptogenic therapies will require a
better understanding of the molecular mechanisms of
epileptogenesis. Animal and human studies of
temporal lobe epilepsy
have long implicated newly-born dentate granule cells (DGCs) as
mediating many of these epileptogenic changes. Work from our lab
described in this report demonstrates that phosphatase and tensin
homolog (PTEN) deletion need only occur in up to 25% of hippocampal
DGCs to produce a severe epilepsy syndrome in mice. This was the
first direct evidence provided to show that abnormal DGCs can cause
the disease. It is also conceivable that a certain threshold level
of abnormal cells must be reached to provoke epileptogenesis; but
after this threshold is passed, additional abnormal cells have no
further impact. We hypothesize that the severity of epilepsy is
dependent on the number of abnormal DGCs in these animals, and we
predict, therefore, that modifying the model to produce fewer
abnormal cells will mitigate the disease phenotype. The second
chapter, previously published in Neuron, details the selective
deletion of PTEN from hippocampal granule cells. The third chapter
directly tests our guiding hypothesis, whether deletion from a
smaller number of DGCs, roughly 5% or less, is sufficient to cause
epilepsy. In the fourth chapter, we will describe initial
experiments that test whether and when electroencephalogram (EEG)
abnormalities can be reversed by ablating irregular DGCs. These
studies will provide novel insights into 1) the role these neurons
play in chronic epilepsy, and 2) whether we can identify a
therapeutic window to interfere with disease
progression.
Advisors/Committee Members: Eliassen, James (Committee Chair).
Subjects/Keywords: Neurology; TEMPORAL LOBE EPILEPSY; HIPPOCAMPAL GRANULE CELLS; DENTATE GYRUS; PTEN; MTOR; HIPPOCAMPAL SEIZURES
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rolle, I. J. (2015). Threshold for Hippocampal Dentate Granule Cell Mediated
Epileptogenesis. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448873759
Chicago Manual of Style (16th Edition):
Rolle, Isaiah J. “Threshold for Hippocampal Dentate Granule Cell Mediated
Epileptogenesis.” 2015. Doctoral Dissertation, University of Cincinnati. Accessed January 26, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448873759.
MLA Handbook (7th Edition):
Rolle, Isaiah J. “Threshold for Hippocampal Dentate Granule Cell Mediated
Epileptogenesis.” 2015. Web. 26 Jan 2021.
Vancouver:
Rolle IJ. Threshold for Hippocampal Dentate Granule Cell Mediated
Epileptogenesis. [Internet] [Doctoral dissertation]. University of Cincinnati; 2015. [cited 2021 Jan 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448873759.
Council of Science Editors:
Rolle IJ. Threshold for Hippocampal Dentate Granule Cell Mediated
Epileptogenesis. [Doctoral Dissertation]. University of Cincinnati; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448873759
University of Cambridge
17.
Kent, Brianne A.
Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models.
Degree: PhD, 2015, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/254763https://www.repository.cam.ac.uk/bitstream/1810/254763/3/license.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/254763/8/Kent-2015-PhD.pdf.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/254763/10/Kent-2015-Agreement.pdf.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/254763/9/Kent-2015-PhD.pdf.jpg
;
https://www.repository.cam.ac.uk/bitstream/1810/254763/11/Kent-2015-Agreement.pdf.jpg
► This dissertation investigates the mechanisms underlying pattern separation, using rodent models and behavioural tasks that assess the use of representations for similar stimuli. Pattern separation…
(more)
▼ This dissertation investigates the mechanisms underlying pattern separation, using rodent models and behavioural tasks that assess the use of representations for similar stimuli. Pattern separation is a theoretical mechanism involving the transformation of inputs into output representations that are less correlated to each other. Because of this orthogonalizing process, similar experiences are stored as discrete non-overlapping representations. Studying pattern separation emphasizes the important but often overlooked fact that successful memory involves more than just remembering events over a period of time, but also differentiating between similar memories. Through a series of experiments this dissertation adds support to the literature that the dentate gyrus (DG) subregion of the hippocampus is important for pattern separation when encoding spatial and contextual inputs. Using the Spontaneous Location Recognition (SLR) task it is shown the brain-derived neurotrophic factor (BDNF) can improve performance by acting via N-methyl-D-aspartate (NMDA) glutamate receptors in the DG and adult-born hippocampal neurons. Manipulating the level of neurogenesis by inhibiting Wnt signalling or by administering acyl-ghrelin systemically is shown to impair and enhance performance on SLR, respectively. Using a novel exposure paradigm in combination with SLR, it is demonstrated for the first time that the relationship between pattern separation and neurogenesis may be reciprocal, such that inhibiting neurogenesis impairs pattern separation, enhancing neurogenesis improves pattern separation, and performing pattern separation enhances the production or survival of adult-born hippocampal neurons. Finally, it is shown that the TgTauP301L mouse model of dementia exhibits spatial and object recognition memory impairments once aged, recapitulating a dementia-like phenotype. Understanding the mechanisms that contribute to effective pattern separation may help elucidate the processes underlying the memory impairment experienced by AD patients. This dissertation concludes with a critical discussion about whether pattern separation can be studied using behavioural paradigms.
Subjects/Keywords: Research Subject Categories::SOCIAL SCIENCES::Social sciences::Psychology; pattern separation; temporal lobe; dentate gyrus; hippocampus; spontaneous location recognition
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kent, B. A. (2015). Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/254763https://www.repository.cam.ac.uk/bitstream/1810/254763/3/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/8/Kent-2015-PhD.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/10/Kent-2015-Agreement.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/9/Kent-2015-PhD.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/254763/11/Kent-2015-Agreement.pdf.jpg
Chicago Manual of Style (16th Edition):
Kent, Brianne A. “Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models.” 2015. Doctoral Dissertation, University of Cambridge. Accessed January 26, 2021.
https://www.repository.cam.ac.uk/handle/1810/254763https://www.repository.cam.ac.uk/bitstream/1810/254763/3/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/8/Kent-2015-PhD.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/10/Kent-2015-Agreement.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/9/Kent-2015-PhD.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/254763/11/Kent-2015-Agreement.pdf.jpg.
MLA Handbook (7th Edition):
Kent, Brianne A. “Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models.” 2015. Web. 26 Jan 2021.
Vancouver:
Kent BA. Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models. [Internet] [Doctoral dissertation]. University of Cambridge; 2015. [cited 2021 Jan 26].
Available from: https://www.repository.cam.ac.uk/handle/1810/254763https://www.repository.cam.ac.uk/bitstream/1810/254763/3/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/8/Kent-2015-PhD.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/10/Kent-2015-Agreement.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/9/Kent-2015-PhD.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/254763/11/Kent-2015-Agreement.pdf.jpg.
Council of Science Editors:
Kent BA. Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models. [Doctoral Dissertation]. University of Cambridge; 2015. Available from: https://www.repository.cam.ac.uk/handle/1810/254763https://www.repository.cam.ac.uk/bitstream/1810/254763/3/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/8/Kent-2015-PhD.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/10/Kent-2015-Agreement.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/254763/9/Kent-2015-PhD.pdf.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/254763/11/Kent-2015-Agreement.pdf.jpg
University of Edinburgh
18.
Hong, Sujin.
Neural correlates of beat and metre perception : the role of the inferior frontal gyrus.
Degree: PhD, 2015, University of Edinburgh
URL: http://hdl.handle.net/1842/21112
► Temporal regularity and metrical organisation are important factors in beat and metre perception. The current thesis aims to investigate neural correlates of beat and metre…
(more)
▼ Temporal regularity and metrical organisation are important factors in beat and metre perception. The current thesis aims to investigate neural correlates of beat and metre perception in healthy non-musician volunteers, using functional magnetic resonance imaging (fMRI). In particular, the thesis focuses on determining the role of the Inferior Frontal Gyrus (IFG, in particular BA44/45) in beat and metre perception. The IFG has been proposed to be involved in higher order cognitive processes during various temporal sequencing, such as speech, movement, and music. Previous studies have shown that the temporal processing of rhythm activates auditory and sensorimotor areas, but the role of the IFG in rhythm perception has not yet been fully understood. Study 1 investigated beat perception in complex rhythms, in which the addition of volume accents either enhanced or weakened the beat perception, resulting in Unaccented, Beat Accented or Non-Beat Accented rhythms. Participants (N=14; 6 males) listened to rhythm pairs across all three conditions, and judged whether each rhythm pair was the same or different. Results showed that left IFG activation (BA44) was significantly greater during the Non-Beat Accented condition compared to Beat Accented condition, whereas the right IFG activation showed no significant difference between the two conditions. Study 2 investigated metre perception of a series of isochronous sequences, of which metrical organisation was grouped by 2/4 (C2), 3/4 (C3), or 4/4 (C4) using pitch accents, or remained without metrical grouping (or 1/4, C1). The same participants (N=15; 6 males) listened to the stimuli and indicated the perceived metrical grouping level. Results showed that the activation of bilateral IFG parametrically increased from C2 to C3 to C4. Interestingly, the activation was found to be significantly greater in C1 relative to C2, suggesting that involuntary subjective in C1 may increase the brain response. Converging results from both Study 1 and Study 2 demonstrated, firstly, that the bilateral IFG is involved in rhythm perception in addition to the auditory and sensorimotor areas, including primary and secondary auditory areas, supplementary motor areas, premotor areas, insula, and basal ganglia. Secondly, the left IFG (BA44) in particular was significantly modulated by the rhythmic complexity relating to both temporal regularity and metrical organisation, while showing the suppression during the Beat Accented rhythm condition of Study 1 and the binary pattern (C2) of Study 2. This thesis argues that the left IFG (BA44) may have the role the higher order cognitive processing, such as attention and prediction, in the perception of hierarchical structures in metric rhythms.
Subjects/Keywords: 612.8; rhythm perception; temporal regularity; metrical organisation; Functional Magnetic Resonance Imaging; fMRI; Inferior Frontal Gyrus; IFG
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hong, S. (2015). Neural correlates of beat and metre perception : the role of the inferior frontal gyrus. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/21112
Chicago Manual of Style (16th Edition):
Hong, Sujin. “Neural correlates of beat and metre perception : the role of the inferior frontal gyrus.” 2015. Doctoral Dissertation, University of Edinburgh. Accessed January 26, 2021.
http://hdl.handle.net/1842/21112.
MLA Handbook (7th Edition):
Hong, Sujin. “Neural correlates of beat and metre perception : the role of the inferior frontal gyrus.” 2015. Web. 26 Jan 2021.
Vancouver:
Hong S. Neural correlates of beat and metre perception : the role of the inferior frontal gyrus. [Internet] [Doctoral dissertation]. University of Edinburgh; 2015. [cited 2021 Jan 26].
Available from: http://hdl.handle.net/1842/21112.
Council of Science Editors:
Hong S. Neural correlates of beat and metre perception : the role of the inferior frontal gyrus. [Doctoral Dissertation]. University of Edinburgh; 2015. Available from: http://hdl.handle.net/1842/21112
University of Rochester
19.
Lee, Susan Sojung.
Audiovisual Integration During Language Comprehension:The
Neural Basis of Social Communication in Autism and Typical
Development.
Degree: PhD, 2011, University of Rochester
URL: http://hdl.handle.net/1802/15887
► Nonverbal information, such as motion cues from the lips, face, hands, and body, contributes significantly to social communication as it provides helpful information for understanding…
(more)
▼ Nonverbal information, such as motion cues from the
lips, face, hands, and
body, contributes significantly to social
communication as it provides helpful
information for understanding
a speaker’s communicative intent. Consequently,
difficulty
interpreting or using nonverbal cues early in development may
contribute to
later social communication impairments. Abnormal
attention to and use of nonverbal
cues is a commonly reported
trait in individuals with autism spectrum disorders, but
little is
known about the neurobiological underpinnings of this deficit. This
thesis
aimed to examine the neural basis for (1) the
interpretation of biological motion cues,
and (2) the integration
of biological motion with simultaneously occurring speech.
Using
functional magnetic resonance imaging, we measured blood-oxygen
level dependent signal as participants viewed silent videos of
communicatively
meaningful and meaningless gestures. Three groups
of participants were recruited:
typical adults, typically
developing children, and children with high functioning
autism. In
all three groups, direct comparison of the meaningful and
meaningless
conditions showed that meaningful gestures
preferentially recruit a left hemisphere
dominant network,
including inferior frontal gyrus, superior temporal sulcus/gyrus,
and limbic regions. Meaningless gestures, on the other hand,
preferentially recruited a
right lateralized network of
fronto-parietal action processing regions. Comparisons
between
groups showed that the neural circuitry subserving biological
motion
processing is well developed by late childhood. Moreover,
there were no significant
differences between the two groups of
children, suggesting preservation of function in
the neural
network underlying perception and identification of biological
motion in
individuals with high functioning autism.
To
investigate the neural networks underlying audiovisual integration,
we
designed an object identification task that was presented using
unimodal speech
descriptions alone, unimodal gesture descriptions
alone, or bimodal speech-gesture
combinations. Regions
demonstrating increased activity during the bimodal
integration
task were identified using direct comparison of the speech-gesture
condition versus the two combined unimodal conditions. Consistent
with previously
reported findings, typical adults had increased
activity selectively in the superior
temporal region, bilaterally.
For typically developing children, however, activity in
this
region was constrained to the left hemisphere, with additional
clusters in occipital
regions. Of particular interest, children
with high functioning autism showed
increased cortical response
associated with the bimodal condition exclusively in the
occipital
cortex. Moreover, signal change in the superior temporal region
was
negatively correlated with a measure of autism-related social
deficits.
Results demonstrate that the superior temporal region of
the human brain is
involved in multiple roles. It is likely that
activity in this…
Subjects/Keywords: Autism; Audiovisual Integration; Gesture; Multimodal; Superior Temporal Sulcus
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, S. S. (2011). Audiovisual Integration During Language Comprehension:The
Neural Basis of Social Communication in Autism and Typical
Development. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/15887
Chicago Manual of Style (16th Edition):
Lee, Susan Sojung. “Audiovisual Integration During Language Comprehension:The
Neural Basis of Social Communication in Autism and Typical
Development.” 2011. Doctoral Dissertation, University of Rochester. Accessed January 26, 2021.
http://hdl.handle.net/1802/15887.
MLA Handbook (7th Edition):
Lee, Susan Sojung. “Audiovisual Integration During Language Comprehension:The
Neural Basis of Social Communication in Autism and Typical
Development.” 2011. Web. 26 Jan 2021.
Vancouver:
Lee SS. Audiovisual Integration During Language Comprehension:The
Neural Basis of Social Communication in Autism and Typical
Development. [Internet] [Doctoral dissertation]. University of Rochester; 2011. [cited 2021 Jan 26].
Available from: http://hdl.handle.net/1802/15887.
Council of Science Editors:
Lee SS. Audiovisual Integration During Language Comprehension:The
Neural Basis of Social Communication in Autism and Typical
Development. [Doctoral Dissertation]. University of Rochester; 2011. Available from: http://hdl.handle.net/1802/15887
Queens University
20.
Wayne, Rachel.
Cognitive and Visual Speech Contributions to Speech Perception in Challenging Listening Conditions
.
Degree: Psychology, Queens University
URL: http://hdl.handle.net/1974/15239
► Speech perception routinely takes place in noisy or degraded listening environments, leading to ambiguity in the identity of the speech token. Here, I present one…
(more)
▼ Speech perception routinely takes place in noisy or degraded listening environments, leading to ambiguity in the identity of the speech token. Here, I present one review paper and two experimental papers that highlight cognitive and visual speech contributions to the listening process, particularly in challenging listening environments. First, I survey the literature linking audiometric age-related hearing loss and cognitive decline and review the four proposed causal mechanisms underlying this link. I argue that future research in this area requires greater consideration of the functional overlap between hearing and cognition. I also present an alternative framework for understanding causal relationships between age-related declines in hearing and cognition, with emphasis on the interconnected nature of hearing and cognition and likely contributions from multiple causal mechanisms. I also provide a number of testable hypotheses to examine how impairments in one domain may affect the other. In my first experimental study, I examine the direct contribution of working memory (through a cognitive training manipulation) on speech in noise comprehension in older adults. My results challenge the efficacy of cognitive training more generally, and also provide support for the contribution of sentence context in reducing working memory load. My findings also challenge the ubiquitous use of the Reading Span test as a pure test of working memory. In a second experimental (fMRI) study, I examine the role of attention in audiovisual speech integration, particularly when the acoustic signal is degraded. I demonstrate that attentional processes support audiovisual speech integration in the middle and superior temporal gyri, as well as the fusiform gyrus. My results also suggest that the superior temporal sulcus is sensitive to intelligibility enhancement, regardless of how this benefit is obtained (i.e., whether it is obtained through visual speech information or speech clarity). In addition, I also demonstrate that both the cingulo-opercular network and motor speech areas are recruited in difficult listening conditions. Taken together, these findings augment our understanding of cognitive contributions to the listening process and demonstrate that memory, working memory, and executive control networks may flexibly be recruited in order to meet listening demands in challenging environments.
Subjects/Keywords: Hearing
;
Cognition
;
Speech perception
;
Cognitive training
;
Working memory
;
Cognitive aging
;
Hearing impairment
;
Speech communication
;
Speech in noise
;
Attention
;
Audiology
;
Audiometry
;
Cognitive hearing science
;
Reading span test
;
Superior temporal gyrus
;
Fusiform face area
;
Audiovisual speech integration
;
Auditory aging
;
Cingulo-opercular network
;
Noise-vocoded speech
;
Degraded speech
;
Age-related hearing loss
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APA (6th Edition):
Wayne, R. (n.d.). Cognitive and Visual Speech Contributions to Speech Perception in Challenging Listening Conditions
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/15239
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wayne, Rachel. “Cognitive and Visual Speech Contributions to Speech Perception in Challenging Listening Conditions
.” Thesis, Queens University. Accessed January 26, 2021.
http://hdl.handle.net/1974/15239.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wayne, Rachel. “Cognitive and Visual Speech Contributions to Speech Perception in Challenging Listening Conditions
.” Web. 26 Jan 2021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Wayne R. Cognitive and Visual Speech Contributions to Speech Perception in Challenging Listening Conditions
. [Internet] [Thesis]. Queens University; [cited 2021 Jan 26].
Available from: http://hdl.handle.net/1974/15239.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
Wayne R. Cognitive and Visual Speech Contributions to Speech Perception in Challenging Listening Conditions
. [Thesis]. Queens University; Available from: http://hdl.handle.net/1974/15239
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
21.
Elseedy, Heba.
Rôle du réseau supramammillaire-gyrus dentelé en condition physiologique et dans les épilepsies du lobe temporal : une approche génétique : Role of the suprammamillary dentate gyrus network in physiological condition and in mesial temporal lobe epilepsy : an optogenetic approach.
Degree: Docteur es, Neurosciences, 2019, Aix-Marseille; Université d'Alexandrie
URL: http://www.theses.fr/2019AIXM0113
► Les épilepsies du lobe temporal médian sont parmi les formes les plus courantes d'épilepsie partielle pharmaco-résistante de l'adulte.Ces épilepsies sont caractérisées par la survenue de…
(more)
▼ Les épilepsies du lobe temporal médian sont parmi les formes les plus courantes d'épilepsie partielle pharmaco-résistante de l'adulte.Ces épilepsies sont caractérisées par la survenue de crises récurrentes spontanées associées à des décharges synchrones de populations neuronales générées par un réseau multi structural Zone Epileptogène. Le noyau supramammillaire (SuM) innervant tous les cortex limbiques. Chez le rat, il a été démontré qu’il était impliqué dans le contrôle des rythmes thêta de l’hippocampe et des fonctions associées telles que le sommeil paradoxal, ainsi que l’apprentissage et la mémoire émotionnelle. Il a été démontré que les projections des neurones de la région latérale du SuM (SuML) qui innervent le gyrus dentelé dorsal (dDG) présentent un phénotype unique à la foie GABAergique et Glutamatergique. De plus cette voie est réorganisée chez les animaux épileptiques. Dans cette thèse, nous démontrons que:Tous les neurones du SuML innervant le DG co-expriment les marqueurs pour les neurotransmissions GABAergique et glutamatergique. L'activation de cette voie augmente la puissance et la fréquence des oscillations thêta ainsi que la puissance du gamma,pendant le SP et induit la décharge des CGs.La population de neurones GABA / GLU du SuML innervant le dDG est hétérogène. Parmi ces neurones,70% contiennent la calrétinine et 30% n'en contiennent pas.Chez les souris épileptiques, la voie SuML-dDG est réorganisée . Nos résultats préliminaires utilisant les techniques d’optogénétique in vivo montrent que l'activation ou l'inactivation de cette voie ne modifie pas la durée de la crise. Cependant, cette voie module la variabilité de la contenu fréquentiel des crises.
Mesial temporal lobe epilepsies are among the most common clinical forms of drug-resistant partial epilepsies in adults. These epilepsies are characterized by the occurrence of spontaneous recurrent seizures associated with excessive and hypersynchronous discharges of neuronal populations generated by a multi-structural epileptogenic zone involving several regions of the limbic system. The Supramammillary nucleus (SuM) is innervating all limbic cortex. In rat, it has been shown to be involved in the control of hippocampal theta rhythms and associated functions such as REM sleep as well as emotional learning and memory. More recently, it was shown that the projections from neurons of lateral region of the SuM (SuML) that innervate the dorsal dentate gyrus (DG) display a unique GABAergic and Glutamatergic neurotransmitter phenotype and this pathway is reorganized in epileptic animals. In this thesis,we demonstrated that: All the neurons from the SuML innervating the dDG co-express markers for both GABAergic and glutamatergic neurotransmissions. Activation of this pathway increases theta power and frequency as well as gamma power during REM sleep and induced net firing of some GCs. The population of GABA/GLU SuML neurons innervating the dDG is heterogeneous. Among these neurons 70% contain calretinin whereas 30% do not. In epileptic mice the…
Advisors/Committee Members: Esclapez, Monique (thesis director), Abdelmeguid El Sayed, Nabila (thesis director).
Subjects/Keywords: Epilepsies du lobe temporal median; Hippocampe; Gyrus Dentelé; Noyeau supramammillaire; Souris trangenique; Transporteur vésiculaire du glutamate (VGLUT-2); Transporteur vésiculaire du GABA (VGAT); Calretinin; Plasticité; Pilocarpine; Mesial Temporal Lobe Epilepsy; Hippocampus; Dentate Gyrus; Supramammillary nucleus; Transgenic mouse; Vesicular glutamate transporter 2 (VGLUT-2); Vesicular GABA transporter (VGAT); Calretinin; Plasticity; Pilocarpine
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APA ·
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APA (6th Edition):
Elseedy, H. (2019). Rôle du réseau supramammillaire-gyrus dentelé en condition physiologique et dans les épilepsies du lobe temporal : une approche génétique : Role of the suprammamillary dentate gyrus network in physiological condition and in mesial temporal lobe epilepsy : an optogenetic approach. (Doctoral Dissertation). Aix-Marseille; Université d'Alexandrie. Retrieved from http://www.theses.fr/2019AIXM0113
Chicago Manual of Style (16th Edition):
Elseedy, Heba. “Rôle du réseau supramammillaire-gyrus dentelé en condition physiologique et dans les épilepsies du lobe temporal : une approche génétique : Role of the suprammamillary dentate gyrus network in physiological condition and in mesial temporal lobe epilepsy : an optogenetic approach.” 2019. Doctoral Dissertation, Aix-Marseille; Université d'Alexandrie. Accessed January 26, 2021.
http://www.theses.fr/2019AIXM0113.
MLA Handbook (7th Edition):
Elseedy, Heba. “Rôle du réseau supramammillaire-gyrus dentelé en condition physiologique et dans les épilepsies du lobe temporal : une approche génétique : Role of the suprammamillary dentate gyrus network in physiological condition and in mesial temporal lobe epilepsy : an optogenetic approach.” 2019. Web. 26 Jan 2021.
Vancouver:
Elseedy H. Rôle du réseau supramammillaire-gyrus dentelé en condition physiologique et dans les épilepsies du lobe temporal : une approche génétique : Role of the suprammamillary dentate gyrus network in physiological condition and in mesial temporal lobe epilepsy : an optogenetic approach. [Internet] [Doctoral dissertation]. Aix-Marseille; Université d'Alexandrie; 2019. [cited 2021 Jan 26].
Available from: http://www.theses.fr/2019AIXM0113.
Council of Science Editors:
Elseedy H. Rôle du réseau supramammillaire-gyrus dentelé en condition physiologique et dans les épilepsies du lobe temporal : une approche génétique : Role of the suprammamillary dentate gyrus network in physiological condition and in mesial temporal lobe epilepsy : an optogenetic approach. [Doctoral Dissertation]. Aix-Marseille; Université d'Alexandrie; 2019. Available from: http://www.theses.fr/2019AIXM0113
Universiteit Utrecht
22.
Werf, I.A. van der.
Looking at both sides now: An explorative study investigating non-lateralized dysfunctions in hemispatial neglect and in various spatial frames of reference.
Degree: 2015, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/324130
► Hemispatial neglect is an enabling disorder that is most common after right-sided brain lesions and is perceived as a heterogeneous syndrome. For example, patients can…
(more)
▼ Hemispatial neglect is an enabling disorder that is most common after right-sided brain lesions and is perceived as a heterogeneous syndrome. For example, patients can show neglect in different sensory modalities (visual, auditory, e.g.) and at different spatial distances (near and far). According to recent studies, neglect is related to non-lateralized impairments such as deficits in selective attention, sustained attention and spatial working memory. Based on these non-lateralized dysfunctions found in neglect patients, the current study explored whether there would be a difference between neglect patients (n = 59) and stroke patients without neglect (n = 127) on a neuropsychological test battery, containing tests that measured the non-lateralized functions short term memory, working memory, executive functioning (planning, mental flexibility) and (divided) attention. In addition, research shows that the degree of certain non-lateralized impairments correlates with the severity of the hemispatial neglect. In the present study, this was also investigated for the (non-lateralized) domains memory and executive functioning. The final part of the study focused on the association between non-lateralized dysfunctions and hemispatial neglect in different regions of space. Because of the dissociation between neglect in near- and in far space, the present study investigated whether patients with neglect in near space (n= 17) and neglect in far space (n = 14) would perform differently on the test battery. The test results reveal that neglect patients do not perform better or worse on the neuropsychological tests included in the test battery compared to the stroke patients without neglect. Moreover, there was no relation between neglect severity and cognitive performance on the domains memory and executive functioning. Finally, the results show there are no differences in cognitive profile between the patients with neglect in near space and the patients with neglect in far space. It is suggested that the test results of the present study can be accounted for by the anatomical organization of non-lateralized functions, and its association with the brain sites related to the neglect syndrome.
Advisors/Committee Members: Nijboer, T., van den Berg, E..
Subjects/Keywords: Keywords: neglect; spatial cognition; cognitive profile; superior temporal cortex; posterior parietal cortex
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APA (6th Edition):
Werf, I. A. v. d. (2015). Looking at both sides now: An explorative study investigating non-lateralized dysfunctions in hemispatial neglect and in various spatial frames of reference. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/324130
Chicago Manual of Style (16th Edition):
Werf, I A van der. “Looking at both sides now: An explorative study investigating non-lateralized dysfunctions in hemispatial neglect and in various spatial frames of reference.” 2015. Masters Thesis, Universiteit Utrecht. Accessed January 26, 2021.
http://dspace.library.uu.nl:8080/handle/1874/324130.
MLA Handbook (7th Edition):
Werf, I A van der. “Looking at both sides now: An explorative study investigating non-lateralized dysfunctions in hemispatial neglect and in various spatial frames of reference.” 2015. Web. 26 Jan 2021.
Vancouver:
Werf IAvd. Looking at both sides now: An explorative study investigating non-lateralized dysfunctions in hemispatial neglect and in various spatial frames of reference. [Internet] [Masters thesis]. Universiteit Utrecht; 2015. [cited 2021 Jan 26].
Available from: http://dspace.library.uu.nl:8080/handle/1874/324130.
Council of Science Editors:
Werf IAvd. Looking at both sides now: An explorative study investigating non-lateralized dysfunctions in hemispatial neglect and in various spatial frames of reference. [Masters Thesis]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/324130
Texas Medical Center
23.
Nath, Audrey R.
The Neural Substrates of Multisensory Speech Perception.
Degree: PhD, 2011, Texas Medical Center
URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/120
► Comprehending speech is one of the most important human behaviors, but we are only beginning to understand how the brain accomplishes this difficult task.…
(more)
▼ Comprehending speech is one of the most important human behaviors, but we are only beginning to understand how the brain accomplishes this difficult task. One key to speech perception seems to be that the brain integrates the independent sources of information available in the auditory and visual modalities in a process known as multisensory integration. This allows speech perception to be accurate, even in environments in which one modality or the other is ambiguous in the context of noise. Previous electrophysiological and functional magnetic resonance imaging (fMRI) experiments have implicated the posterior
superior temporal sulcus (STS) in auditory-visual integration of both speech and non-speech stimuli. While evidence from prior imaging studies have found increases in STS activity for audiovisual speech compared with unisensory auditory or visual speech, these studies do not provide a clear mechanism as to how the STS communicates with early sensory areas to integrate the two streams of information into a coherent audiovisual percept. Furthermore, it is currently unknown if the activity within the STS is directly correlated with strength of audiovisual perception. In order to better understand the cortical mechanisms that underlie audiovisual speech perception, we first studied the STS activity and connectivity during the perception of speech with auditory and visual components of varying intelligibility. By studying fMRI activity during these noisy audiovisual speech stimuli, we found that STS connectivity with auditory and visual cortical areas mirrored perception; when the information from one modality is unreliable and noisy, the STS interacts less with the cortex processing that modality and more with the cortex processing the reliable information. We next characterized the role of STS activity during a striking audiovisual speech illusion, the McGurk effect, to determine if activity within the STS predicts how strongly a person integrates auditory and visual speech information. Subjects with greater susceptibility to the McGurk effect exhibited stronger fMRI activation of the STS during perception of McGurk syllables, implying a direct correlation between strength of audiovisual integration of speech and activity within an the multisensory STS.
Advisors/Committee Members: Michael Beauchamp, Ph.D., Ruth Heidelberger, M.D., Ph.D., Anne Sereno, Ph.D..
Subjects/Keywords: audiovisual speech; functional connectivity; fMRI; McGurk effect; superior temporal sulcus; Cognitive Neuroscience; Systems Neuroscience
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APA (6th Edition):
Nath, A. R. (2011). The Neural Substrates of Multisensory Speech Perception. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/120
Chicago Manual of Style (16th Edition):
Nath, Audrey R. “The Neural Substrates of Multisensory Speech Perception.” 2011. Doctoral Dissertation, Texas Medical Center. Accessed January 26, 2021.
https://digitalcommons.library.tmc.edu/utgsbs_dissertations/120.
MLA Handbook (7th Edition):
Nath, Audrey R. “The Neural Substrates of Multisensory Speech Perception.” 2011. Web. 26 Jan 2021.
Vancouver:
Nath AR. The Neural Substrates of Multisensory Speech Perception. [Internet] [Doctoral dissertation]. Texas Medical Center; 2011. [cited 2021 Jan 26].
Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/120.
Council of Science Editors:
Nath AR. The Neural Substrates of Multisensory Speech Perception. [Doctoral Dissertation]. Texas Medical Center; 2011. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/120
Michigan Technological University
24.
Lin, Hongyi.
Temporal Trends and Spatial Variabilities of PCB concentrations in Lake Trout from Lake Superior from 1995 to 2013.
Degree: MS, Department of Civil and Environmental Engineering, 2016, Michigan Technological University
URL: https://digitalcommons.mtu.edu/etdr/189
► It has been frequently reported that concentrations of PCBs in the Great Lakes fish have declined dramatically since their ban on production and use…
(more)
▼ It has been frequently reported that concentrations of PCBs in the Great Lakes fish have declined dramatically since their ban on production and use in 1979 in the United States, although some studies suggested that recent rates of decline are leveling off. In order to examine the
temporal trends and spatial variabilities of PCB concentrations in lake trout (
Salvelinus namaycush) from Lake
Superior during the past two decades, statistical analyses were performed on fish sample data collected by two national agencies (U.S. EPA, Environment and Climate Change Canada) and three state agencies (Michigan Department of Environmental Quality, Minnesota Department of Natural Resources, Wisconsin Department of Natural Resources) from both the United States and Canada from 1976 to 2013. Because of a change in PCB analytical methodology in the mid-1990s, intercomparison between data recorded by the previous technique and the improved technique is not feasible.
Because most organochlorine compounds are easily bound to fatty tissues in fish, lipid content has been commonly considered as a predictor of PCB levels. Also, larger fish were assumed to have higher PCBs in their bodies. Multiple linear regression analyses, setting time, lipid content, and fish length as three independent variables, revealed that lipid content had little impact on PCB concentrations at all sites except Whitefish Bay since 1995, which is in contrast to some previous studies. However, a strong positive correlation between PCBs and fish length, in good agreement with previous research, was observed at all sites except Whitefish Bay over the same period.
It has been discovered that PCB concentrations vary among several sampling locations within Lake
Superior. The general pattern was that the western sites had significantly higher concentrations than the eastern sites. When the entire historical record was analyzed,
temporal trends were evident in all datasets. However, only at Keweenaw Point (U.S. EPA) was significant (
p = 0.0005) declining trends in total PCB concentrations observed after 1995. In Wisconsin sites, the declining trend was marginal significant (
p = 0.04) during the same period. In other locations, no
temporal trends were found but large annual fluctuations occurred for unknown reasons. PCB concentrations at most sites have not achieved the reduction target of 100 ng/g ww for wildlife and human health protection established by the U.S. EPA. It is still difficult to predict when fish will be able to be consumed without limitation in this region.
Advisors/Committee Members: Noel R. Urban, Judith A. Perlinger.
Subjects/Keywords: PCBs; lake trout; Lake Superior; temporal trend; spatial variability; contamination assessment; Environmental Engineering
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APA (6th Edition):
Lin, H. (2016). Temporal Trends and Spatial Variabilities of PCB concentrations in Lake Trout from Lake Superior from 1995 to 2013. (Masters Thesis). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/189
Chicago Manual of Style (16th Edition):
Lin, Hongyi. “Temporal Trends and Spatial Variabilities of PCB concentrations in Lake Trout from Lake Superior from 1995 to 2013.” 2016. Masters Thesis, Michigan Technological University. Accessed January 26, 2021.
https://digitalcommons.mtu.edu/etdr/189.
MLA Handbook (7th Edition):
Lin, Hongyi. “Temporal Trends and Spatial Variabilities of PCB concentrations in Lake Trout from Lake Superior from 1995 to 2013.” 2016. Web. 26 Jan 2021.
Vancouver:
Lin H. Temporal Trends and Spatial Variabilities of PCB concentrations in Lake Trout from Lake Superior from 1995 to 2013. [Internet] [Masters thesis]. Michigan Technological University; 2016. [cited 2021 Jan 26].
Available from: https://digitalcommons.mtu.edu/etdr/189.
Council of Science Editors:
Lin H. Temporal Trends and Spatial Variabilities of PCB concentrations in Lake Trout from Lake Superior from 1995 to 2013. [Masters Thesis]. Michigan Technological University; 2016. Available from: https://digitalcommons.mtu.edu/etdr/189
25.
Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira.
Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.
Degree: 博士（医学）, 2014, Nara Medical University / 奈良県立医科大学
URL: http://hdl.handle.net/10564/2716
► 22q11 deletion syndrome (22q11DS) frequently accompanies psychiatric conditions, some of which are classified as schizophrenia and bipolar disorder in the current diagnostic categorization. However, it…
(more)
▼ 22q11 deletion syndrome (22q11DS) frequently accompanies psychiatric conditions, some of which are classified as schizophrenia and bipolar disorder in the current diagnostic categorization. However, it remains elusive how the chromosomal microdeletion leads to the mental manifestation at the mechanistic level. Here we show that a 22q11DS mouse model with a deletion of 18 orthologous genes of human 22q11 (Df1/+ mice) has deficits in migration of cortical interneurons and hippocampal dentate precursor cells. Furthermore, Df1/+ mice show functional defects in Chemokine receptor 4/Chemokine ligand 12 (Cxcr4/Cxcl12; Sdf1) signaling, which reportedly underlie interneuron migration. Notably, the defects in interneuron progenitors are rescued by ectopic expression of Dgcr8, one of the genes in 22q11 microdeletion. Furthermore, heterozygous knockout mice for Dgcr8 show similar neurodevelopmental abnormalities as Df1/+ mice. Thus, Dgcr8-mediated regulation of microRNA is likely to underlie Cxcr4/Cxcl12 signaling and associated neurodevelopmental defects. Finally, we observe that expression of CXCL12 is decreased in olfactory neurons from sporadic cases with schizophrenia compared with normal controls. Given the increased risk of 22q11DS in schizophrenia that frequently shows interneuron abnormalities, the overall study suggests that CXCR4/CXCL12 signaling may represent a common downstream mediator in the pathophysiology of schizophrenia and related mental conditions.
博士（医学）・乙1331号・平成26年3月17日
Subjects/Keywords: hippocampus; dentate gyrus
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APA (6th Edition):
Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, A. (2014). Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/2716
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. “Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.” 2014. Thesis, Nara Medical University / 奈良県立医科大学. Accessed January 26, 2021.
http://hdl.handle.net/10564/2716.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. “Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.” 2014. Web. 26 Jan 2021.
Vancouver:
Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa A. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2014. [cited 2021 Jan 26].
Available from: http://hdl.handle.net/10564/2716.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa A. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. [Thesis]. Nara Medical University / 奈良県立医科大学; 2014. Available from: http://hdl.handle.net/10564/2716
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Rutgers University
26.
Yohn, Christine Noel.
Role of Dentate gyrus in stress and the response to antidepressant treatment.
Degree: PhD, Depression, 2020, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/64367/
► Despite stress-associated disorders having a higher incidence rate in females, historically preclinical research in rodents mainly utilizes males. Rodent chronic stress paradigms, such as chronic…
(more)
▼ Despite stress-associated disorders having a higher incidence rate in females, historically preclinical research in rodents mainly utilizes males. Rodent chronic stress paradigms, such as chronic social defeat and chronic corticosterone administration, were mainly designed and validated in males and subsequent attempts to use these paradigms in females has demonstrated sex differences in the behavioral and HPA axis response to these stressors. We evaluated the behavioral and neuroendocrine response to two novel social stress paradigms, social instability stress (SIS) and chronic non-discriminatory social defeat stress (CNSDS). SIS exposes adult mice to unstable same-sex social hierarchies for 7 weeks. The CNSDS model, a modified social defeat protocol, simultaneously introduces male and female C57BL/6J mice into the home cage of resident CD-1 aggressors for 10 daily 5-minute sessions, with CD-1 aggressors attacking males and females indiscriminately. In the CNSDS paradigm, stress resilient (RES) and susceptible (SUS) subpopulations emerge in both sexes, with SUS mice displaying increased negative valence behaviors relative to RES and control mice in both sexes. SUS male and female mice also displayed hypothalamus-pituitary-adrenal (HPA) axis activation following CNSDS exposure. SIS effectively induces negative valence behaviors and HPA axis activation in both males and females. Additionally, the effects of SIS on negative valence behaviors are reversed by chronic antidepressant treatment with fluoxetine (FLX) in both males and females.
Chronic stress paradigms in rodents also permit the study of antidepressant treatment resistance. Inhibition of mature Dentate Gyrus (DG) granule cells, through both cell autonomous Gi-coupled receptors and the local microcircuitry, may be critical for mounting a behavioral response to antidepressants. The novelty-suppressed feeding (NSF) task allows us to behaviorally assess response status because a bimodal distribution emerges within the stress+FLX groups. Responders to FLX have a shorter latency to eat the pellet within the brightly light center of the NSF arena than non-responders. We observe that non-responders to FLX have more DG activation and less hippocampal neurogenesis. Additionally, DREADD mediated inhibition of the ventral DG results in a decrease in negative valence behaviors. Interestingly, non-responders to FLX are converted into responders following DREADD mediated inhibition of the ventral DG. Results from these projects can further our understanding of the involvement of the DG in response to stress and antidepressant response.
Advisors/Committee Members: Samuels, Benjamin A (chair), Kusnecov, Alexander (internal member), Wagner, George (internal member), Anacker, Christopher (outside member), School of Graduate Studies.
Subjects/Keywords: Dentate gyrus; Psychology
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APA (6th Edition):
Yohn, C. N. (2020). Role of Dentate gyrus in stress and the response to antidepressant treatment. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/64367/
Chicago Manual of Style (16th Edition):
Yohn, Christine Noel. “Role of Dentate gyrus in stress and the response to antidepressant treatment.” 2020. Doctoral Dissertation, Rutgers University. Accessed January 26, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/64367/.
MLA Handbook (7th Edition):
Yohn, Christine Noel. “Role of Dentate gyrus in stress and the response to antidepressant treatment.” 2020. Web. 26 Jan 2021.
Vancouver:
Yohn CN. Role of Dentate gyrus in stress and the response to antidepressant treatment. [Internet] [Doctoral dissertation]. Rutgers University; 2020. [cited 2021 Jan 26].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/64367/.
Council of Science Editors:
Yohn CN. Role of Dentate gyrus in stress and the response to antidepressant treatment. [Doctoral Dissertation]. Rutgers University; 2020. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/64367/
Pontifícia Universidade Católica de São Paulo
27.
Celso Eduardo Lellis de Andrade Carvalho.
A Contribuição Social devida pelo empregado: Incidente sobre créditos resultantes de condenação judicial em face do enunciado 368 do TST.
Degree: 2006, Pontifícia Universidade Católica de São Paulo
URL: http://www.sapientia.pucsp.br//tde_busca/arquivo.php?codArquivo=3829
► Partindo da dimensão sintática da linguagem e apoiado no pensamento jurídico-filosófico dos Professores Lourival Vilanova e Paulo de Barros Carvalho, este trabalho busca analisar a…
(more)
▼ Partindo da dimensão sintática da linguagem e apoiado no pensamento jurídico-filosófico dos Professores Lourival Vilanova e Paulo de Barros Carvalho, este trabalho busca analisar a estrutura da norma jurídica tributária que ampara a cobrança da contribuição social devida pelo empregado incidente sobre os créditos resultantes de condenação judicial, com ênfase ao elemento temporal do respectivo fato jurídico tributário, colocando-a em confronto com o entendimento proferido pelo Tribunal Superior do Trabalho, através do Enunciado 368
Starting out with the syntactic dimension of the language and supported in the juridical-philosophical thought from Professors Lourival Vilanova and Paulo de Barros Carvalho, this work seeks analyze the structure of the juridical tax norm that supports collecting the social contribution due by the employee assessed on the credits resulting from judicial conviction, with emphasis on the temporal element of the respective juridical tax fact, placing it in confrontation with the understanding pronounced by the Superior Labor Court, through Statement 368
Advisors/Committee Members: Paulo de Barros Carvalho.
Subjects/Keywords: Elemento temporal; Enunciado 368 do Tribunal Superior do Trabalho; Temporal element; Social contribution; Statement 368 from the Superior Labor Court; Brasil – Tribunal Superior do Trabalho; DIREITO TRIBUTARIO; Direito tributario – Brasil; Contribuição social; Contribuicoes sociais – Brasil
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APA (6th Edition):
Carvalho, C. E. L. d. A. (2006). A Contribuição Social devida pelo empregado: Incidente sobre créditos resultantes de condenação judicial em face do enunciado 368 do TST. (Thesis). Pontifícia Universidade Católica de São Paulo. Retrieved from http://www.sapientia.pucsp.br//tde_busca/arquivo.php?codArquivo=3829
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Carvalho, Celso Eduardo Lellis de Andrade. “A Contribuição Social devida pelo empregado: Incidente sobre créditos resultantes de condenação judicial em face do enunciado 368 do TST.” 2006. Thesis, Pontifícia Universidade Católica de São Paulo. Accessed January 26, 2021.
http://www.sapientia.pucsp.br//tde_busca/arquivo.php?codArquivo=3829.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Carvalho, Celso Eduardo Lellis de Andrade. “A Contribuição Social devida pelo empregado: Incidente sobre créditos resultantes de condenação judicial em face do enunciado 368 do TST.” 2006. Web. 26 Jan 2021.
Vancouver:
Carvalho CELdA. A Contribuição Social devida pelo empregado: Incidente sobre créditos resultantes de condenação judicial em face do enunciado 368 do TST. [Internet] [Thesis]. Pontifícia Universidade Católica de São Paulo; 2006. [cited 2021 Jan 26].
Available from: http://www.sapientia.pucsp.br//tde_busca/arquivo.php?codArquivo=3829.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Carvalho CELdA. A Contribuição Social devida pelo empregado: Incidente sobre créditos resultantes de condenação judicial em face do enunciado 368 do TST. [Thesis]. Pontifícia Universidade Católica de São Paulo; 2006. Available from: http://www.sapientia.pucsp.br//tde_busca/arquivo.php?codArquivo=3829
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
28.
Singer, Jedediah Miller.
Vision over time: Temporal integration in the temporal
lobe.
Degree: PhD, Neuroscience, 2009, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:11024/
► Visual recognition of faces and objects is often modeled as a process whose input is an instantaneous snapshot. Here we show that this snapshot can…
(more)
▼ Visual recognition of faces and objects is often
modeled as a process whose input is an instantaneous snapshot. Here
we show that this snapshot can integrate information over a
considerable period of time, at both behavioral and neuronal
levels. Human face perception has often been described as a
holistic process; we replicate previous findings about configural
atomicity. We then show that properly-configured face parts can
interact in a holistic fashion even when they are presented
asynchronously, separated by 120 ms of dynamic noise. Integration
at this time scale can also occur at the single-neuron level. When
a monkey views animated characters performing various actions,
neurons in the
superior temporal sulcus and inferior
temporal
cortex show selectivity both for the actor and the action being
performed. Removing form information, using a novel random-dot
rendering technique, alters the representation of action more than
removing motion information (by means of a strobe effect). Finally,
we examine the influence of
temporal context on neural response,
pitting local motion against sequences of general pose information.
Temporal cortex neurons appear to rely heavily on sequences of
poses when representing actions, integrating animation frames into
poses whose
temporal extent is approximately 120 ms. Neurons of the
form-based ventral visual system appear not to be simple
snapshot-processors, but have
temporal receptive fields of
considerable extent and functional utility.
Advisors/Committee Members: Sheinberg, David (Director), Tarr, Michael (Reader), Donoghue, John (Reader), Poggio, Tomaso (Reader).
Subjects/Keywords: temporal
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APA ·
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Manager
APA (6th Edition):
Singer, J. M. (2009). Vision over time: Temporal integration in the temporal
lobe. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:11024/
Chicago Manual of Style (16th Edition):
Singer, Jedediah Miller. “Vision over time: Temporal integration in the temporal
lobe.” 2009. Doctoral Dissertation, Brown University. Accessed January 26, 2021.
https://repository.library.brown.edu/studio/item/bdr:11024/.
MLA Handbook (7th Edition):
Singer, Jedediah Miller. “Vision over time: Temporal integration in the temporal
lobe.” 2009. Web. 26 Jan 2021.
Vancouver:
Singer JM. Vision over time: Temporal integration in the temporal
lobe. [Internet] [Doctoral dissertation]. Brown University; 2009. [cited 2021 Jan 26].
Available from: https://repository.library.brown.edu/studio/item/bdr:11024/.
Council of Science Editors:
Singer JM. Vision over time: Temporal integration in the temporal
lobe. [Doctoral Dissertation]. Brown University; 2009. Available from: https://repository.library.brown.edu/studio/item/bdr:11024/
Universidade do Rio Grande do Sul
29.
Santos, Fábio Pires.
Avaliação por tomografia computadorizada da correspondência entre a eminência arqueada e o canal semicircular superior.
Degree: 2017, Universidade do Rio Grande do Sul
URL: http://hdl.handle.net/10183/164380
► O objetivo deste estudo é avaliar a correspondência anatômica entre a eminência arqueada e o canal semicircular superior na superfície da fossa craniana média. Este…
(more)
▼ O objetivo deste estudo é avaliar a correspondência anatômica entre a eminência arqueada e o canal semicircular superior na superfície da fossa craniana média. Este estudo transversal descritivo foi realizado em um hospital terciário. Setenta e cinco pacientes consecutivos (150 lados), submetidos à tomografia computadorizada de alta resolução dos ossos temporais, foram analisados por dois autores. Para cada exame, a relação anatômica entre a eminência arqueada e o canal semicircular superior foi classificada como coincidente ou não coincidente. Distâncias entre os parâmetros anatômicos de maior utilidade na cirurgia da fossa média e prevalência de deiscência do canal semicircular superior também foram estudadas. A eminência arqueada foi coincidente com o canal semicircular superior em apenas 31.3% dos casos. Não foi possível identificar a eminência arqueada em 33 exames (22.0%). Deiscência do canal semicircular superior foi encontrada em cinco casos (3.3%). Poucos milímetros separaram a cóclea do canal semicircular superior. As medidas secundárias foram caracterizadas por ampla variabilidade. A eminência arqueada não se sobrepõe sistematicamente ao canal semicircular superior e não deve ser usada rotineiramente como uma referência para a localização dessa estrutura.
The objective of this study is to evaluate the anatomical coincidence between the arcuate eminence and the superior semicircular canal at the middle cranial fossa surface. This crosssectional descriptive study was performed at a tertiary hospital. Seventy-five consecutive patients (150 sides) who underwent bilateral high-resolution temporal bone computed tomography scans were analyzed by two authors. In each scan, the anatomical relationship between the arcuate eminence and the superior semicircular canal was classified as coincident or non-coincident. Distances between the most applicable anatomical landmarks for middle cranial fossa surgery and the prevalence of superior semicircular canal dehiscence were also studied. The arcuate eminence matched the semicircular canal in only 31.3% of cases. It was impossible to identify the arcuate eminence in 33 scans (22.0%). Semicircular canal dehiscence was found in 5 cases (3.3%). A few millimeters separated the cochea from SSC; secondary measurements were characterized by broad variability. The arcuate eminence does not systematically overlie the superior semicircular canal and should not be routinely used as a reference for reaching this structure in the context of middle fossa surgery.
Advisors/Committee Members: Isolan, Gustavo Rassier.
Subjects/Keywords: Arcuate eminence; Osso temporal; Tomografia computadorizada por raios X; Superior semicircular canal; Middle fossa anatomy; Anatomia; Middle fossa approach; Temporal bone; Surgery
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APA ·
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APA (6th Edition):
Santos, F. P. (2017). Avaliação por tomografia computadorizada da correspondência entre a eminência arqueada e o canal semicircular superior. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/164380
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Santos, Fábio Pires. “Avaliação por tomografia computadorizada da correspondência entre a eminência arqueada e o canal semicircular superior.” 2017. Thesis, Universidade do Rio Grande do Sul. Accessed January 26, 2021.
http://hdl.handle.net/10183/164380.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Santos, Fábio Pires. “Avaliação por tomografia computadorizada da correspondência entre a eminência arqueada e o canal semicircular superior.” 2017. Web. 26 Jan 2021.
Vancouver:
Santos FP. Avaliação por tomografia computadorizada da correspondência entre a eminência arqueada e o canal semicircular superior. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2017. [cited 2021 Jan 26].
Available from: http://hdl.handle.net/10183/164380.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Santos FP. Avaliação por tomografia computadorizada da correspondência entre a eminência arqueada e o canal semicircular superior. [Thesis]. Universidade do Rio Grande do Sul; 2017. Available from: http://hdl.handle.net/10183/164380
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
30.
Zhao, Chen.
Novel Biomarkers in Infants: Developing Optical Imaging
Solutions for the Measurement of Early Brain Development.
Degree: 2019, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:318097
► Language and social-emotional atypicalities may act as important early markers of potential developmental problems in children. Advances in psychophysiological tools have led to an understanding…
(more)
▼ Language and social-emotional atypicalities may act
as important early markers of potential developmental problems in
children. Advances in psychophysiological tools have led to an
understanding of the neural correlates that underpin infant voice
and vocal emotion processing as the precursors to language and
social-emotional brain development. However, there is little
evidence for the longitudinal developmental trajectory of infant
voice and vocal emotion processing. In addition, the influence of
early experience, especially maternal caregiving behaviour, on the
infant voice and vocal emotion processing is less clear. To address
research gaps relating to the early infant language and
social-emotional neural development, this PhD study involved
developing an acceptable and reliable method to observe changing
voice and vocal emotion processing in the infant brain in the first
year of life. The study aimed (a) to develop and pilot a functional
Near-Infrared Spectroscopy (fNIRS) protocol that could be
acceptably and feasibly applied in a clinical setting in order
potentially to monitor and evaluate the neurological underpinnings
of early language and social-emotional development; (b) to track
longitudinal changes in neural correlates of human voice and
emotional vocalisation processing in typically developing infants
at the age of 6, 9 and 12 months; (c) to explore the role of early
maternal caregiving behaviour as a possible mediator in the healthy
development of voice and vocal emotion processing in infants.
Chapter 2 describes methodological considerations in the
longitudinal assessment of infant voice and vocal emotion neural
processing. Chapter 3 compared fNIRS data analysis methods between
standardised analysis and Independent Component Analysis (ICA)
implanted emotion-sensitive components identification procedures
(paper 1). Chapter 4 (paper 2) reports the acceptability and
feasibility of piloting the fNIRS paradigm in a non-research,
community-based clinical setting in typically developing infants at
their ages of 6, 9 and 12 months. Chapter 5 to 7 (paper 3 to 5)
report the observation of infant neural development in processing
emotional vocalisations, human voice and non-vocal sounds over
time, and the influence of maternal caregiving behaviour on the
infant’s neural response to vocal emotion. Mother-infant pairs
successfully completed the longitudinal study with high retention
and satisfaction rate. We found consistent
temporal cortical
activations to auditory stimuli, particularly to happy
vocalisations and non-vocal sounds, but the activation locations
within
temporal cortices were inconsistent over time. Right
temporal cortical responses to angry vocalisations were
significantly increased with age. Six-month-old infant’s neural
responses to vocal anger were significantly associated with
maternal directiveness. We also report a lack of significantly
enhanced neural responses to voice than to non-vocal stimuli.
Findings suggest that the fNIRS paradigm has a promising outlook
for the clinical use in infants…
Advisors/Committee Members: SCHIESSL, INGO I, WAN, MING MW, Abel, Kathryn, Schiessl, Ingo, Wan, Ming.
Subjects/Keywords: infant; fNIRS; ICA; SNR; feasibility; acceptability; clinic; mother-infant interaction; emotional prosody; voice; non-vocal; temporal cortex; superior temporal cortex; social-emotional
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zhao, C. (2019). Novel Biomarkers in Infants: Developing Optical Imaging
Solutions for the Measurement of Early Brain Development. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:318097
Chicago Manual of Style (16th Edition):
Zhao, Chen. “Novel Biomarkers in Infants: Developing Optical Imaging
Solutions for the Measurement of Early Brain Development.” 2019. Doctoral Dissertation, University of Manchester. Accessed January 26, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:318097.
MLA Handbook (7th Edition):
Zhao, Chen. “Novel Biomarkers in Infants: Developing Optical Imaging
Solutions for the Measurement of Early Brain Development.” 2019. Web. 26 Jan 2021.
Vancouver:
Zhao C. Novel Biomarkers in Infants: Developing Optical Imaging
Solutions for the Measurement of Early Brain Development. [Internet] [Doctoral dissertation]. University of Manchester; 2019. [cited 2021 Jan 26].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:318097.
Council of Science Editors:
Zhao C. Novel Biomarkers in Infants: Developing Optical Imaging
Solutions for the Measurement of Early Brain Development. [Doctoral Dissertation]. University of Manchester; 2019. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:318097
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Open Access Theses and Dissertations
