subject:( male infertility )

1. Vijayalakshmi J. Genetic Studies of Male Infertility.

Degree: Human Genetics, 2005, Sri Ramachandra University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/17907

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Infertility is the inability of a sexually active, non-contraception couple to achieve pregnancy in one year. Generally, infertility is classified as either primary (67-71%) when… (more)

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Infertility is the inability of a sexually active, non-contraception couple to achieve pregnancy in one year. Generally, infertility is classified as either primary (67-71%) when no pregnancy has ever occurred or secondary (29-33%) where there has been a pregnancy, regardless of the outcome. It affects 13-18% of couples of reproductive age worldwide and is treatable in many cases [1]. Although, infertility is not life threatening, it is psychologically a traumatic condition associated with social stigma in certain societies resulting in intense social and parental pressure to attain biological parenthood; hence many infertile couples choose to undergo assisted reproductive technology as a form of treatment. In recent years, it has been demonstrated that up to 50% of infertility cases are associated with male factor because of spermatogenic failure; interestingly in which ~70% of the underlying etiological cause(s) are known but remaining 30% are referred to as idiopathic infertility [2] Thus, the etiology of male infertility is complex and can be reflected in a variety of conditions like defective spermatogenesis, congenital absence of bilateral vas deferens (CABVD), infections, and immunological disorders such as antisperm-antibodies, diabetes, obesity, pituitary disorders, and imbalance in levels of gonadotrophic hormones. Genetic factors are considered to be significant in male infertility [3]. Hence, the aim of the study is to investigate the chromosomal aberrations, azoospermia factor (AZF), cystic fibrosis transmembrane regulator (CFTR) gene mutations in the peripheral blood lymphocytes (PBL) of infertile men with abnormal sperm parameter and compare it with healthy fertile control subjects to delineate the genetic causes of male infertility. This thesis comprises of six chapters. The first chapter summarizes about male factor infertility: incidence, classification, etiology, genetic factors, and treatment options. In around 50% of infertile couples, male-related causes are involved, such as impaired sperma

Reference included

Advisors/Committee Members: Venkatachalam P.

Subjects/Keywords: Genetic Studies; Male Infertility

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APA (6^th Edition):

J, V. (2005). Genetic Studies of Male Infertility. (Thesis). Sri Ramachandra University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/17907

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

J, Vijayalakshmi. “Genetic Studies of Male Infertility.” 2005. Thesis, Sri Ramachandra University. Accessed January 22, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/17907.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

J, Vijayalakshmi. “Genetic Studies of Male Infertility.” 2005. Web. 22 Jan 2021.

Vancouver:

J V. Genetic Studies of Male Infertility. [Internet] [Thesis]. Sri Ramachandra University; 2005. [cited 2021 Jan 22]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17907.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

J V. Genetic Studies of Male Infertility. [Thesis]. Sri Ramachandra University; 2005. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17907

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – San Diego

2. Barnes, Liberty Elizabeth Walther. Preconceived notions : the social construction of male infertility.

Degree: 2011, University of California – San Diego

URL: http://www.escholarship.org/uc/item/6q84m12f

► Gender scholars argue that in Western culture hegemonic gender beliefs are widespread and stable, and individuals' access to resources and power are contingent upon their… (more)

▼ Gender scholars argue that in Western culture hegemonic gender beliefs are widespread and stable, and individuals' access to resources and power are contingent upon their ability to conform to these ideals (Ridgeway and Correll 2004 ; West and Zimmerman 2002). However, they also argue that gender is a fluid and dynamic aspect of identity, as demonstrated by individuals' ability to revise personal notions of gender based on other salient features of identity, including, race, class, age, sexual orientation or physical (dis)abilities (Connell 1995 ; Fenstermaker and West 2002 ; Kimmel 2006 ; Ridgeway and Correll 2004 ; West and Zimmerman 2002). This dissertation uses male infertility as a case study for exploring what happens when the perceived foundations of masculinity are destabilized in the lives of heterosexual married men. Male factor infertility is a clinical condition that affects nearly half of the more than seven million infertile couples in the United States. For this original research study, I employed mixed qualitative research methods, including ethnographic observation in male infertility clinics, in-depth interviews with male infertility specialists, clinic staff, infertile men and their wives, and content analysis of medical texts and conference addresses, in order to examine how medical institutions and individuals socially construct male infertility. I argue that the social processes of constructing gender and negotiating masculinity are tightly intertwined with the process of constructing disease. Early in this dissertation I show that preconceived notions regarding women's responsibility for all aspects of reproduction have historically shaped popular understandings of male infertility and hindered the development and organization of male infertility as a medical specialty. I describe how medical practices are designed around preconceived notions of men as sexually knowledgeable and experienced, yet all the while strive to protect presumably fragile masculine identities. I detail the various ways infertile men work to redefine their condition in terms that downplay infertility's threat to masculinity. Throughout this dissertation I argue that gender-constructing and disease-constructing processes are inextricable, because notions of gender inform understandings of disease. When disease presents a threat to gender identities, individuals create new understandings of disease in order to negotiate and stabilize their personal gender identities

Subjects/Keywords: UCSD Dissertations, Academic Sociology (Discipline); Infertility Social aspects Male; Psychological aspects Infertility Male; Infertility Public opinion Male; Masculinity

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APA (6^th Edition):

Barnes, L. E. W. (2011). Preconceived notions : the social construction of male infertility. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/6q84m12f

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Barnes, Liberty Elizabeth Walther. “Preconceived notions : the social construction of male infertility.” 2011. Thesis, University of California – San Diego. Accessed January 22, 2021. http://www.escholarship.org/uc/item/6q84m12f.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Barnes, Liberty Elizabeth Walther. “Preconceived notions : the social construction of male infertility.” 2011. Web. 22 Jan 2021.

Vancouver:

Barnes LEW. Preconceived notions : the social construction of male infertility. [Internet] [Thesis]. University of California – San Diego; 2011. [cited 2021 Jan 22]. Available from: http://www.escholarship.org/uc/item/6q84m12f.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barnes LEW. Preconceived notions : the social construction of male infertility. [Thesis]. University of California – San Diego; 2011. Available from: http://www.escholarship.org/uc/item/6q84m12f

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ghana

3. Akuffo, G.A. Knowledge and Perceptions about Male Infertility in the Kumasi Metropolis .

Degree: 2017, University of Ghana

URL: http://ugspace.ug.edu.gh/handle/123456789/23826

► Introduction: Infertility is the inability of a couple to conceive after one year of regular unprotected sexual intercourse. In the Ghanaian society women bear the… (more)

Subjects/Keywords: Perceptions; Knowledge; Male Infertility; Kumasi Metropolis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Akuffo, G. A. (2017). Knowledge and Perceptions about Male Infertility in the Kumasi Metropolis . (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/23826

Chicago Manual of Style (16^th Edition):

Akuffo, G A. “Knowledge and Perceptions about Male Infertility in the Kumasi Metropolis .” 2017. Masters Thesis, University of Ghana. Accessed January 22, 2021. http://ugspace.ug.edu.gh/handle/123456789/23826.

MLA Handbook (7^th Edition):

Akuffo, G A. “Knowledge and Perceptions about Male Infertility in the Kumasi Metropolis .” 2017. Web. 22 Jan 2021.

Vancouver:

Akuffo GA. Knowledge and Perceptions about Male Infertility in the Kumasi Metropolis . [Internet] [Masters thesis]. University of Ghana; 2017. [cited 2021 Jan 22]. Available from: http://ugspace.ug.edu.gh/handle/123456789/23826.

Council of Science Editors:

Akuffo GA. Knowledge and Perceptions about Male Infertility in the Kumasi Metropolis . [Masters Thesis]. University of Ghana; 2017. Available from: http://ugspace.ug.edu.gh/handle/123456789/23826

University of Adelaide

4. Tunc, Ozlem. Investigation of the role of oxidative stress in male infertility.

Degree: 2011, University of Adelaide

URL: http://hdl.handle.net/2440/66099

► In recent years, there has been some suggestion of an increase in male factor infertility in the industrialized countries with a decline in sperm counts… (more)

▼ In recent years, there has been some suggestion of an increase in male factor infertility in the industrialized countries with a decline in sperm counts and a rise in sperm pathology. Male factor infertility is a multifactorial phenomenon that is observed in approximately half of infertile couples and affects one man in 20 in the general population. The potential causes of male infertility arise from a number of factors including genetic, lifestyle factors and chronic diseases. However, a high proportion of infertile male patients have now been shown to have defective sperm functions related to oxidative stress. Oxidative stress in semen has been speculated as one of the major factors causing male infertility and has been identified in 30-80% of cases of male infertility. While oxidative stress is accepted as a significant pathology, there is currently an inadequate knowledge of the exact mechanisms by which oxidative stress develops in male infertility, as well as a lack of an easy and reliable method for the measurement of seminal oxidative stress in routine clinical use. The main objective of this doctoral thesis is to investigate the underlying causes for oxidative stress in infertile men and the mechanisms by which oxidative stress develops. Furthermore it will also examine the effectiveness of an oral antioxidant therapy for treatment of seminal oxidative stress. During these doctoral studies experiments were designed with the aims of: • Developing a standardized protocol for the measurement of seminal oxidative stress, that can be conducted in the average clinical laboratory with minimal additional equipment (NBT Assay) • Examining the causes for oxidative stress in semen. Obesity has previously been identified as a cause of systemic oxidative stress. Therefore I examined if obesity causes oxidative stress to sperm. Seminal inflammation and its role in oxidative damage in semen are also investigated. • Determination if antioxidant supplementation is an effective treatment of oxidative sperm damage. • Assessment of the relation between Oxidative stress and sperm DNA methylation. Previous studies have linked male infertility with epigenetic abnormalities of the male genome. Since oxidative stress has been shown to interfere with somatic cell epigenetic programming I investigated the possibility of a similar link in sperm. It is hoped that advances outlined in this thesis will have made a significant contribution to the diagnosis, prevention and treatment of the male infertility. Advisors/Committee Members: Tremellen, Kelton Paul (advisor), Thompson, Jeremy Gilbert E. (advisor), School of Paediatrics and Reproductive Health (school).

Subjects/Keywords: oxidative stress; male infertility; NBT assay; antioxidants

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tunc, O. (2011). Investigation of the role of oxidative stress in male infertility. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/66099

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tunc, Ozlem. “Investigation of the role of oxidative stress in male infertility.” 2011. Thesis, University of Adelaide. Accessed January 22, 2021. http://hdl.handle.net/2440/66099.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tunc, Ozlem. “Investigation of the role of oxidative stress in male infertility.” 2011. Web. 22 Jan 2021.

Vancouver:

Tunc O. Investigation of the role of oxidative stress in male infertility. [Internet] [Thesis]. University of Adelaide; 2011. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2440/66099.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tunc O. Investigation of the role of oxidative stress in male infertility. [Thesis]. University of Adelaide; 2011. Available from: http://hdl.handle.net/2440/66099

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Dohle, Gert. Obstructions of the male reproductive tract: diagnosis and management.

Degree: Department of Internal Medicine, 2001, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/23507

► textabstractIn this thesis several aspects of diagnosis and management of obstructive male infertility are discussed. The introduction gives a general overview of both male infertility… (more)

Subjects/Keywords: male infertility; urology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dohle, G. (2001). Obstructions of the male reproductive tract: diagnosis and management. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/23507

Chicago Manual of Style (16^th Edition):

Dohle, Gert. “Obstructions of the male reproductive tract: diagnosis and management.” 2001. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 22, 2021. http://hdl.handle.net/1765/23507.

MLA Handbook (7^th Edition):

Dohle, Gert. “Obstructions of the male reproductive tract: diagnosis and management.” 2001. Web. 22 Jan 2021.

Vancouver:

Dohle G. Obstructions of the male reproductive tract: diagnosis and management. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2001. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1765/23507.

Council of Science Editors:

Dohle G. Obstructions of the male reproductive tract: diagnosis and management. [Doctoral Dissertation]. Erasmus University Medical Center; 2001. Available from: http://hdl.handle.net/1765/23507

Brandeis University

6. Sikes, Megan. Cystic Fibrosis-related Infertility: Thoughts and Experiences of Men in Romantic Relationships.

Degree: 2016, Brandeis University

URL: http://hdl.handle.net/10192/32315

► Cystic fibrosis (CF) and congenital absence of the vas deferens (CAVD) are conditions caused by mutations in the CFTR gene. Ninety-five percent of men with… (more)

▼ Cystic fibrosis (CF) and congenital absence of the vas deferens (CAVD) are conditions caused by mutations in the CFTR gene. Ninety-five percent of men with CF and/or CAVD have infertility due to azoospermia. Until recently, men with CF were not likely to live into adulthood and because of this, issues surrounding CF-related infertility did not receive much attention. However, as improved care and treatments continue to extend the life expectancy for individuals with CF, the need to understand how affected men are feeling about issues surrounding CF-related infertility is becoming increasingly relevant. The purpose of this study is to explore the experiences of men with CF and/or CAVD in disclosing their infertility to romantic partners, the effects that both disclosure and associated infertility have had on their romantic relationships and their thoughts on reproduction. We used an anonymous online survey and received 37 responses. We found that nearly half of our participants (44.4%) desired more information at the time of learning about CF-related infertility, and that some wished they had learned this information at an earlier age. Almost all participants (97.2%) had disclosed CF-related infertility to their romantic partner and felt supported after doing so. While many men stated they were concerned that their romantic partners would react negatively to learning about CF-related infertility, few (21.4%) felt their partners actually had negative reactions after disclosure. In addition, the majority of men (61.1%) in this study felt like CF-related infertility did not affect their ability to establish romantic relationships. Finally, 75% of men indicated they think about having or already have children, and most men discussed this with their romantic partner. This is one of the first studies to explore the issues men with CF and infertility face and the results provide valuable insight for other men affected by CF and CAVD, as well as the healthcare professionals who provide care for them.

Subjects/Keywords: Cystic Fibrosis; infertility; male infertility; disclosure; romantic partners

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sikes, M. (2016). Cystic Fibrosis-related Infertility: Thoughts and Experiences of Men in Romantic Relationships. (Thesis). Brandeis University. Retrieved from http://hdl.handle.net/10192/32315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sikes, Megan. “Cystic Fibrosis-related Infertility: Thoughts and Experiences of Men in Romantic Relationships.” 2016. Thesis, Brandeis University. Accessed January 22, 2021. http://hdl.handle.net/10192/32315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sikes, Megan. “Cystic Fibrosis-related Infertility: Thoughts and Experiences of Men in Romantic Relationships.” 2016. Web. 22 Jan 2021.

Vancouver:

Sikes M. Cystic Fibrosis-related Infertility: Thoughts and Experiences of Men in Romantic Relationships. [Internet] [Thesis]. Brandeis University; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10192/32315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sikes M. Cystic Fibrosis-related Infertility: Thoughts and Experiences of Men in Romantic Relationships. [Thesis]. Brandeis University; 2016. Available from: http://hdl.handle.net/10192/32315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

7. Prag, Farren Chelsea. Evaluation of standard and development of new sperm function tests in selected primate species .

Degree: 2017, University of the Western Cape

URL: http://hdl.handle.net/11394/5673

► Male infertility in humans has increased in the last few decades and could be as high as 40%, while up to 50% of these men… (more)

▼ Male infertility in humans has increased in the last few decades and could be as high as 40%, while up to 50% of these men have ''unexplained'' (idiopathic) infertility. Although newly developed molecular techniques have great value in detecting subtle causes of male infertility, more detailed sperm functional tests are required to identify compromised fertility, especially in a clinical set-up. Since ethical constraints often preclude the pursuit of many basic research questions in humans, non-human primates (NHPs) have been identified as key models in human-related studies. NHPs are often used in studies on male fertility/infertility, IVF or assisted reproductive technology (ART) procedures, male contraception and reproductive toxicology. However, comparing results of NHP and human studies require that techniques used for assessment must be objective, standardized and sensitive to recognize compromised sperm function. The aim of this study was to evaluate standard sperm functional tests and develop new functional tests using NHP sperm, specifically from vervet monkeys (Chlorocebus aethiops), chacma baboons (Papio ursinus) and rhesus monkeys (Macaca mulatta), for application in human and NHP studies and to ultimately develop a basic primate model. The sperm functions investigated included sperm motility, longevity, vitality, DNA integrity, acrosome reaction, and hyperactivation. The sperm functional tests evaluated were: CASA motility analysis; Sperm Longevity test; Eosin-Nigrosin and Hoechst and Propidium Iodide staining, as well as the use of WST-1 cytotoxicity assay for vitality; the TUNEL assay for DNA integrity; Acrosome Intactness Test; and induction of hyperactivation via stimulants. The validity of each test was investigated by inhibiting sperm function through the use of copper sulphate and cadmium chloride. All functional tests were successfully performed across all three species, except the TUNEL assay for DNA integrity, and was further used for validation testing. Validation testing proved that all sperm functional parameters were significantly affected by the highest concentrations of the chemicals (250 µg/ml CuSO4 and 500 µg/ml CdCl2) and if not significant, trends of reduction were seen. The tests employed were therefore sensitive to the inhibitory effect of the metals. By evaluating these established sperm functional tests we found that primates would serve as good models for research study. Furthermore, we optimized and modified techniques for sperm and functional analysis in these three primate species and this study will standardize protocols for use in future studies on male infertility. Additionally, comparing human and NHP sperm function can possibly reveal or explain the high infertility rates in humans. Advisors/Committee Members: Maree, Liana (advisor).

Subjects/Keywords: Male fertility; Sperm function; Male infertility; Heavy metals; Non-human primates

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Prag, F. C. (2017). Evaluation of standard and development of new sperm function tests in selected primate species . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/5673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Prag, Farren Chelsea. “Evaluation of standard and development of new sperm function tests in selected primate species .” 2017. Thesis, University of the Western Cape. Accessed January 22, 2021. http://hdl.handle.net/11394/5673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Prag, Farren Chelsea. “Evaluation of standard and development of new sperm function tests in selected primate species .” 2017. Web. 22 Jan 2021.

Vancouver:

Prag FC. Evaluation of standard and development of new sperm function tests in selected primate species . [Internet] [Thesis]. University of the Western Cape; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11394/5673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Prag FC. Evaluation of standard and development of new sperm function tests in selected primate species . [Thesis]. University of the Western Cape; 2017. Available from: http://hdl.handle.net/11394/5673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Louisiana State University

8. Glaser, Jeanne Lee. Examining Male Infertility; The Association Between Age, Environment, and Reproductive Success in Male Patients that have Participated in Assisted Reproductive Technology.

Degree: PhD, Human Resources Management, 2015, Louisiana State University

URL: etd-07072015-163646 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2932

► As the number and age of human couples turning to assisted reproductive technology (ART) continues to increase, it is essential for clinicians to understand infertility… (more)

▼ As the number and age of human couples turning to assisted reproductive technology (ART) continues to increase, it is essential for clinicians to understand infertility threats related to both female and male patients. The objective of this study was to evaluate the association between age, environment, and reproductive success in male patients having participated in assisted reproductive technology. In corresponding experiments, male infertility variables such as; age, lifestyle exposures, body mass index (BMI), and infertility length with current partner (ILCP) were investigated. A retrospective collection of clinical male patient data from 2011 to 2014 was evaluated. Thirty-five variables were collected from an original sample of 132 patients and correlated for relationships related to male fertility. A negative relationship was observed between pregnancy and male age, IVF pregnancy and male age, male age and semen volume, and male age and semen progressive motility. A negative correlation was also revealed among alcohol usage and semen volume and alcohol usage and total motile sperm/specimen. Additionally, a positive correlation was observed between ILCP and percent normal semen. The goal of the following study, the clinician survey, was to evaluate and compare differences in opinions. Questions pertained to male infertility factors and fertility clinic practices. Clinicians responded with the following opinion rates; 67.9% felt semen analysis was an effective predictor, 32.7% reported no idea if DNA fragmentation was a predictor, 58.5% were in agreement that male age had somewhat significance, 80.1% responded that genetics and/or epigenetics displayed somewhat or significant influence (41.5% and 39.6%), 58.5% believed male exposure/environmental factors displayed significance, 53.9% felt access to more male information would enable better care. The most commonly seen descriptive variable clinicians reported was ILCP (70.8%), the most important semen characteristic was sperm count (84.6%), the most commonly seen urological variable was vasectomy (77.8%), smoking was the most commonly seen environmental exposure (74.5%), and medication use was the most commonly seen medical variable (84.8%). Clinicians described that 39.1% of patient charts were <25.0% completed and 63.0% of clinicians acknowledged that the industry was not providing adequate male reproductive information to infertility patients.

Subjects/Keywords: environmental threats; human reproduction; retrospective study; infertility professionals; male infertility; clinician survey

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APA (6^th Edition):

Glaser, J. L. (2015). Examining Male Infertility; The Association Between Age, Environment, and Reproductive Success in Male Patients that have Participated in Assisted Reproductive Technology. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-07072015-163646 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2932

Chicago Manual of Style (16^th Edition):

Glaser, Jeanne Lee. “Examining Male Infertility; The Association Between Age, Environment, and Reproductive Success in Male Patients that have Participated in Assisted Reproductive Technology.” 2015. Doctoral Dissertation, Louisiana State University. Accessed January 22, 2021. etd-07072015-163646 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2932.

MLA Handbook (7^th Edition):

Glaser, Jeanne Lee. “Examining Male Infertility; The Association Between Age, Environment, and Reproductive Success in Male Patients that have Participated in Assisted Reproductive Technology.” 2015. Web. 22 Jan 2021.

Vancouver:

Glaser JL. Examining Male Infertility; The Association Between Age, Environment, and Reproductive Success in Male Patients that have Participated in Assisted Reproductive Technology. [Internet] [Doctoral dissertation]. Louisiana State University; 2015. [cited 2021 Jan 22]. Available from: etd-07072015-163646 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2932.

Council of Science Editors:

Glaser JL. Examining Male Infertility; The Association Between Age, Environment, and Reproductive Success in Male Patients that have Participated in Assisted Reproductive Technology. [Doctoral Dissertation]. Louisiana State University; 2015. Available from: etd-07072015-163646 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2932

University of Debrecen

9. Mehra, Ruchi. PATHOPHYSIOLOGY, EVALUATION, AND PHARMACOLOGICAL TREATMENT OF INFERTILITY .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/281122

► Infertility is a disorder of the reproductive system and is defined as the inability to achieve a clinical pregnancy after 12 months of regular, unprotected… (more)

Subjects/Keywords: infertility; female infertility; male infertility; evaluations of infertility; pharmacological treatment of infertility; clomiphene

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APA (6^th Edition):

Mehra, R. (n.d.). PATHOPHYSIOLOGY, EVALUATION, AND PHARMACOLOGICAL TREATMENT OF INFERTILITY . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/281122

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mehra, Ruchi. “PATHOPHYSIOLOGY, EVALUATION, AND PHARMACOLOGICAL TREATMENT OF INFERTILITY .” Thesis, University of Debrecen. Accessed January 22, 2021. http://hdl.handle.net/2437/281122.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mehra, Ruchi. “PATHOPHYSIOLOGY, EVALUATION, AND PHARMACOLOGICAL TREATMENT OF INFERTILITY .” Web. 22 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Mehra R. PATHOPHYSIOLOGY, EVALUATION, AND PHARMACOLOGICAL TREATMENT OF INFERTILITY . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2437/281122.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Mehra R. PATHOPHYSIOLOGY, EVALUATION, AND PHARMACOLOGICAL TREATMENT OF INFERTILITY . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/281122

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of the Western Cape

10. Ilfergane, Abdulkarem. Investigations on the effects of Typha capensis on male reproductive functions .

Degree: 2016, University of the Western Cape

URL: http://hdl.handle.net/11394/5329

► Introduction: Typha capensis, commonly referred to as bulrush also called "love reed'' growing in Southern Africa's wetlands, is one of South Africa indigenous medicinal plants… (more)

▼ Introduction: Typha capensis, commonly referred to as bulrush also called "love reed'' growing in Southern Africa's wetlands, is one of South Africa indigenous medicinal plants that are traditionally used to treat male fertility problems and various other ailments. Previous studies revealed that T. capensis has indeed a beneficial effect on male reproductive functions and aging male symptoms. The T.capensis rhizomes are used in traditional medicine during pregnancy to ensure easy delivery, for venereal diseases, dysmenorrhea, diarrhoea, dysentery, and to enhance the male potency and libido. Typha genuses contain flavones and other phenolic compounds, which exhibit anti-oxidative capacity. Materials and Methods: This study encompasses three parts (part 1: Exposure of different cell lines to crude aqueous extracts of T. capensis rhizomes; part 2: HPLC analysis of Typha capensis crude rhizome extract and exposure of different cell lines to the F1 fraction of the summer season; part 3: Compound identification by means of NMR spectrometric analysis and exposure of different cell lines to bioactive compounds (Quercetin and Naringenin) isolated from T. capensis rhizomes. Part 1: TM3-Leydig cells and LNCaP cells incubated with different concentrations of crude aqueous extract of T. capensis rhizomes (0.01, 0.02, 0.1, 1, 10 and 100 μg/ml) and control (without extract) for 24 and 96 hours, after incubation. The following parameters were evaluated: cell morphology and viability (determined by means of MTT assay). Part 2: The crude extract HPLC profiles were obtained by preparing the extracts for different seasons (Autumn, Winter, Spring, Summer). TM3-Leydig cells, LNCaP cells and PWR-1E cells incubated with different concentrations T. capensis rhizomes extract F1 fraction of the summer season (0.01, 0.02, 0.1, 1, 10 and 100 μg/ml) and control (without extract) for 24 and 96 hours, after incubation. The following parameters were evaluated: cell morphology was observed and recorded, viability (determined by means of MTT assay), testosterone production (testosterone ELISA test), cell early apoptosis (determined by means of Annexin V-Cy3 binding), DNA fragmentation (determined by means of the TUNEL assay). Part 3: NMR spectrometric analysis was performed on a 13C spectra were recorded at 400 MHz. TM3-Leydig cells and LNCaP cells incubated with different concentrations of bioactive compounds (Quercetin and Naringenin) isolated from T. capensis rhizomes, for acute exposure (24, 96 hours) and chronic exposure (96 hours), after incubation, the following parameters were evaluated: cell morphology and viability (determined by means of MTT assay), testosterone production (testosterone ELISA test), cell early apoptosis (determined by means of Annexin V-Cy3 binding) and DNA fragmentation (determined by means of the TUNEL assay). Results: Part 1: for TM3-Leydig cells the results reveal no observable morphological changes and no significant influence on cell viability except at highest concentration indicating cellular stress. However,… Advisors/Committee Members: Henkel, R (advisor), Monsees, T (advisor).

Subjects/Keywords: Typha capensis (bulrush); Male reproductive function; Cytotoxicity; African traditional medicine; Male infertility

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APA (6^th Edition):

Ilfergane, A. (2016). Investigations on the effects of Typha capensis on male reproductive functions . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/5329

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ilfergane, Abdulkarem. “Investigations on the effects of Typha capensis on male reproductive functions .” 2016. Thesis, University of the Western Cape. Accessed January 22, 2021. http://hdl.handle.net/11394/5329.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ilfergane, Abdulkarem. “Investigations on the effects of Typha capensis on male reproductive functions .” 2016. Web. 22 Jan 2021.

Vancouver:

Ilfergane A. Investigations on the effects of Typha capensis on male reproductive functions . [Internet] [Thesis]. University of the Western Cape; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11394/5329.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ilfergane A. Investigations on the effects of Typha capensis on male reproductive functions . [Thesis]. University of the Western Cape; 2016. Available from: http://hdl.handle.net/11394/5329

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

11. Kruger, Alyssa. Evolutionary, Structural and Functional Characterization of X-palindromic Regions and Their Associated Genes.

Degree: PhD, Human Genetics, 2020, University of Michigan

URL: http://hdl.handle.net/2027.42/163084

► The mammalian sex chromosomes are enriched in large (>10kb), nearly identical (>99%) segmental duplications containing testis-expressed gene families. These genomic regions are highly variable in… (more)

▼ The mammalian sex chromosomes are enriched in large (>10kb), nearly identical (>99%) segmental duplications containing testis-expressed gene families. These genomic regions are highly variable in size, ranging from a single duplication present in a palindromic orientation (singleton palindrome) to vast duplications consisting of 10-100s copies present in both palindromic and tandem orientation (palindrome array, or ampliconic array). Both singleton palindromes and palindrome arrays harbor palindrome-associated testis-expressed gene families. In contrast to the majority of single copy sex-linked genes which are post-meiotically silenced, palindrome-associated gene families are expressed post-meiotically. Palindrome-associated gene families independently evolved, with only 30% shared between humans and mice. Furthermore, palindrome-associated gene families are rapidly evolving at the sequence level and can vary substantially in gene copy number, which are hallmarks of genes involved in fertility and speciation. These observations suggest that palindrome-associated genes have evolved mechanisms to evade the post-meiotic gene silencing which single copy X- and Y-linked genes are subject to and that palindrome-associated gene families play important post-meiotic roles in male fertility. In this thesis, I explore the evolutionary history, the importance of palindrome structure, and the functions of genes harbored within palindromes. Using genetically engineered mouse models, I manipulated the structure and copy number of segmental duplications in two singleton palindromes (Mageb5 and 4930567H17Rik) and two palindrome arrays (Slx and Slxl1). My studies demonstrate the post-meiotic expression of palindrome-associated genes correlates with gene copy number and is not dependent on their palindromic orientation. The singleton palindrome gene families, Mageb5 and 4930567H17Rik, are not dosage sensitive as males with a single copy of either gene exhibit no defects in fertility or spermatogenesis as compared to wild-type males. My investigation of Slx and Slxl1 gene families reveal they are Mus-lineage specific, partially redundant, and essential for male fertility. The complete deletion of both Slx and Slxl1, results in post-meiotic spermatogenetic defects and male infertility. Additionally, alterations in Slxl1, but not Slx, gene copy number distorts the ratio of male to female offspring. This unequal transmission of X and Y chromosomes is indicative of meiotic drive, the non-Mendelian transmission of chromosomes. We hypothesize that Slxl1 competes with a related palindromic array associated gene family on the Y-chromosome, Sly, as alterations in the ratio of Slxl1 to Sly copy number impact the offspring sex ratio. We believe meiotic drive contributed to the massive amplification of Slxl1 and Sly on the mouse sex chromosomes. As selfish elements, duplications of Slxl1 and Sly enhanced not only their own transmission but the transmission of the entire X- or Y-chromosome, respectively, resulting in the massive co-amplification… Advisors/Committee Members: Mueller, Jacob L (committee member), Wittkopp, Trisha (committee member), Camper, Sally Ann (committee member), Hammoud, Saher Sue (committee member), Moran, John V (committee member).

Subjects/Keywords: X-palindromes; Male fertility; Male infertility; Meiotic drive; Selfish genetic elements; Genetics; Science

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APA (6^th Edition):

Kruger, A. (2020). Evolutionary, Structural and Functional Characterization of X-palindromic Regions and Their Associated Genes. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/163084

Chicago Manual of Style (16^th Edition):

Kruger, Alyssa. “Evolutionary, Structural and Functional Characterization of X-palindromic Regions and Their Associated Genes.” 2020. Doctoral Dissertation, University of Michigan. Accessed January 22, 2021. http://hdl.handle.net/2027.42/163084.

MLA Handbook (7^th Edition):

Kruger, Alyssa. “Evolutionary, Structural and Functional Characterization of X-palindromic Regions and Their Associated Genes.” 2020. Web. 22 Jan 2021.

Vancouver:

Kruger A. Evolutionary, Structural and Functional Characterization of X-palindromic Regions and Their Associated Genes. [Internet] [Doctoral dissertation]. University of Michigan; 2020. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2027.42/163084.

Council of Science Editors:

Kruger A. Evolutionary, Structural and Functional Characterization of X-palindromic Regions and Their Associated Genes. [Doctoral Dissertation]. University of Michigan; 2020. Available from: http://hdl.handle.net/2027.42/163084

12. Jain, Manish Kumar. The extended clinico-laboratory profile of the male partner in infertility in Bundelkhand Region; -.

Degree: Medicine, 2005, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/11498

None

Bibliography p. 60-64, chart p. 65-66

Advisors/Committee Members: Jain, P K, Sharma, Sanjaya.

Subjects/Keywords: Male Infertility; Clinico-Laboratory

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jain, M. K. (2005). The extended clinico-laboratory profile of the male partner in infertility in Bundelkhand Region; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/11498

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jain, Manish Kumar. “The extended clinico-laboratory profile of the male partner in infertility in Bundelkhand Region; -.” 2005. Thesis, Bundelkhand University. Accessed January 22, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/11498.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jain, Manish Kumar. “The extended clinico-laboratory profile of the male partner in infertility in Bundelkhand Region; -.” 2005. Web. 22 Jan 2021.

Vancouver:

Jain MK. The extended clinico-laboratory profile of the male partner in infertility in Bundelkhand Region; -. [Internet] [Thesis]. Bundelkhand University; 2005. [cited 2021 Jan 22]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11498.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jain MK. The extended clinico-laboratory profile of the male partner in infertility in Bundelkhand Region; -. [Thesis]. Bundelkhand University; 2005. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11498

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Varshney, Manish Kumar. The extended clinico laboratiory profile of the male parter of infertility in Bundelkhand region; -.

Degree: Medicine, 2002, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/12501

None

Reference p. 98-107

Advisors/Committee Members: Arora, R C.

Subjects/Keywords: medicine; male parter; infertility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Varshney, M. K. (2002). The extended clinico laboratiory profile of the male parter of infertility in Bundelkhand region; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/12501

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Varshney, Manish Kumar. “The extended clinico laboratiory profile of the male parter of infertility in Bundelkhand region; -.” 2002. Thesis, Bundelkhand University. Accessed January 22, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/12501.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Varshney, Manish Kumar. “The extended clinico laboratiory profile of the male parter of infertility in Bundelkhand region; -.” 2002. Web. 22 Jan 2021.

Vancouver:

Varshney MK. The extended clinico laboratiory profile of the male parter of infertility in Bundelkhand region; -. [Internet] [Thesis]. Bundelkhand University; 2002. [cited 2021 Jan 22]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/12501.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Varshney MK. The extended clinico laboratiory profile of the male parter of infertility in Bundelkhand region; -. [Thesis]. Bundelkhand University; 2002. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/12501

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Ana Carolina Franco Finotti. ANÁLISE DO POLIMORFISMO DA GLUTATIONA S-TRANSFERASE M1 E T1 EM HOMENS COM INFERTILIDADE IDIOPÁTICA.

Degree: 2009, Universidade Católica de Goiás

URL: http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=793

►

A infertilidade é um problema significante na população mundial, afetando mais de 15% dos casais em idade reprodutiva. Isoladamente o homem contribui com 50% na… (more)

▼

A infertilidade é um problema significante na população mundial, afetando mais de 15% dos casais em idade reprodutiva. Isoladamente o homem contribui com 50% na infertilidade conjugal. As causas genéticas são responsáveis por 60% dos casos de infertilidade idiopática. O polimorfismo em genes que codificam enzimas detoxificantes de fase II pode alterar sua expressão ou função, modificando o biometabolismo de compostos tóxicos ao sistema reprodutor masculino. Os genes GSTM1 e GSTT1 codificam enzimas de mesmo nome, são fundamentais no processo de detoxificação dos xenobióticos endógenos ou exógenos, facilitando sua excreção. O objetivo principal do presente estudo foi detectar o polimorfismo dos genes GSTM1 e GSTT1 em homens com infertilidade idiopática pelo Serviço de Reprodução Humana do Hospital das Clínicas de Goiânia (HC), segundo o laudo dos espermogramas. Ao total foram avaliadas 304 amostras de pacientes com idade entre 15 e 69 anos, diagnosticados com infertilidade idiopática, no período de 2004 a 2006. Os resultados observados em amostras de DNA de sêmen, freqüências genotípicas de 28,6% (30/105) para o genótipo GSTM1/T1(nulo) em indivíduos normais e 50% (6/128) para o GSTM1/T1(nulo) em indivíduos alterados, demonstrando significativa relação estatística entre o polimorfismo do gene GSTM1 e GSTT1 com a infertilidade masculina idiopática. A alteração seminal associada ao genótipo polimórfico de maior freqüência GSTM1/T1 (nulo) é a alteração de número (oligozoospermia) possuindo maior freqüência tanto para GSTM1 (nulo) (78,9%) quanto GSTT1 (nulo) (73,7%), apesar de não ser significante. Analisando as freqüências genotípicas das amostras de sangue não encontramos associações estatísticas com a infertilidade masculina, já que 46,6% (34/76) são GSTM1/T1 (nulo) em indivíduos normais e 58, 4% (73/125) são GSTM1/T1 (nulo) em indivíduos alterados. Não foi encontrada influência significativa do consumo de álcool, cigarro, caxumba e uso de xenobióticos analisados nos parâmetros básicos dos espermogramas analisados. Indivíduos polimórficos para os genes GSTM1 e GSTT1 estão mais susceptíveis a redução na qualidade seminal e possivelmente infertilidade, sendo que indivíduos oligospérmicos são os mais afetados pelo polimorfismo gênico.

The infertility is a significant problem in the world-wide population, more than affecting 15% of the couples in reproductive age. Separately the man contributes with 50% in the conjugal infertility. The genetic causes are responsible for 60% of the cases of idiopathic infertility. The polymorphisms in genes that codify enzymes of phase II detoxificant can modify its expression or function, modifying the biometabolism of toxic composites to the male reproductive system. Genes GSTM1 and GSTT1 they codify enzymes of same name, they are basic in the process of detoxification of the endogenous or exogenous xenobiotics, facilitating its excretion. The aim of the present study was to detect the polymorphism of genes GSTM1 and GSTT1 in men with idiopathic infertility for the Service of…

Advisors/Committee Members: Katia Karina Verolli de Oliveira Moura, Mauri Félix de Sousa, Breno de Faria e Vasconcellos.

Subjects/Keywords: masculina; GSTT1; infertility; GSTM1; xenobiotics; GSTT1; GSTM1; xenobióticos; male; GENETICA; infertilidade

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Finotti, A. C. F. (2009). ANÁLISE DO POLIMORFISMO DA GLUTATIONA S-TRANSFERASE M1 E T1 EM HOMENS COM INFERTILIDADE IDIOPÁTICA. (Thesis). Universidade Católica de Goiás. Retrieved from http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=793

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Finotti, Ana Carolina Franco. “ANÁLISE DO POLIMORFISMO DA GLUTATIONA S-TRANSFERASE M1 E T1 EM HOMENS COM INFERTILIDADE IDIOPÁTICA.” 2009. Thesis, Universidade Católica de Goiás. Accessed January 22, 2021. http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=793.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Finotti, Ana Carolina Franco. “ANÁLISE DO POLIMORFISMO DA GLUTATIONA S-TRANSFERASE M1 E T1 EM HOMENS COM INFERTILIDADE IDIOPÁTICA.” 2009. Web. 22 Jan 2021.

Vancouver:

Finotti ACF. ANÁLISE DO POLIMORFISMO DA GLUTATIONA S-TRANSFERASE M1 E T1 EM HOMENS COM INFERTILIDADE IDIOPÁTICA. [Internet] [Thesis]. Universidade Católica de Goiás; 2009. [cited 2021 Jan 22]. Available from: http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=793.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Finotti ACF. ANÁLISE DO POLIMORFISMO DA GLUTATIONA S-TRANSFERASE M1 E T1 EM HOMENS COM INFERTILIDADE IDIOPÁTICA. [Thesis]. Universidade Católica de Goiás; 2009. Available from: http://tede.biblioteca.ucg.br/tde_busca/arquivo.php?codArquivo=793

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

15. Koppers, Adam John. Significance of mitochondrial reactive oxygen species production in male infertility.

Degree: PhD, 2010, University of Newcastle

URL: http://hdl.handle.net/1959.13/804406

►

Research Doctorate - Doctor of Philosophy (PhD)

Male infertility is a relatively common condition affecting 1 in 20 men of reproductive age. The aetiology of… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Male infertility is a relatively common condition affecting 1 in 20 men of reproductive age. The aetiology of this condition is thought to involve the excessive generation of reactive oxygen species (ROS) by human spermatozoa; however the cause and sub-cellular origins of this aberrant activity is unknown. The objective of this doctoral thesis was to determine the importance of sperm mitochondria in creating oxidative stress associated with defective sperm function and subsequently to investigate causes of increased mitochondrial ROS generation. In the first study, intracellular measurement of mitochondrial ROS generation and lipid peroxidation was performed using the fluorescent probes MitoSOX red and BODIPY C11 in conjunction with flow cytometry. Effects on sperm movement were measured by computer-assisted sperm analysis. Defective human spermatozoa spontaneously generated mitochondrial ROS in a manner that was negatively correlated with motility. The induction of mitochondria ROS resulted in peroxidative damage to the midpiece and a loss of sperm movement that could be prevented by the concomitant presence of α-tocopherol. Concluding that the sperm mitochondria make a significant contribution to the oxidative stress exhibited by defective human spermatozoa. In order to investigate causes of irregular mitochondrial ROS production, we demonstrated that defective human sperm populations are characterized by high cellular contents of both total and free fatty acids using gas chromatography. The free unsaturated fatty acid content of these cells was positively correlated with the induction of mitochondrial superoxide generation. This relationship was causal and mediated by the range of unsaturated fatty acids that are present in human spermatozoa. Direct exposure of these cells to free unsaturated fatty acids stimulated mitochondrial superoxide generation and precipitated a loss of motility and an increase in oxidative DNA damage, two key attributes of male infertility. We followed with examination of the ability of human spermatozoa to undergo apoptosis and generate mitochondrial ROS. We report that these cells are prevented from entering the apoptotic pathway as long as the PI3kinase/AKT complex is phosphorylated. If PI3 kinase phosphorylation is inhibited with wortmannin then these cells default to an intrinsic apoptotic cascade characterized by caspase activation in the cytosol, annexin V binding to the cell surface, mitochondrial ROS generation, cytoplasmic vacuolization, oxidative DNA damage and motility loss. However the physical architecture of the cell subsequently prevents endonucleases released from the mitochondria or activated in the cytosol from penetrating the sperm nucleus and, as a result DNA fragmentation does not occur although oxidative DNA adducts can clearly be detected. These results for the first time highlight the importance of mitochondrial ROS generation in human spermatozoa in the aetiology of male infertility. Subsequent studies revealed…

Advisors/Committee Members: University of Newcastle. Faculty of Science and Information Technology, School of Environmental and Life Sciences.

Subjects/Keywords: male infertility; reactive oxygen species; mitochondrial; sperm function

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koppers, A. J. (2010). Significance of mitochondrial reactive oxygen species production in male infertility. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/804406

Chicago Manual of Style (16^th Edition):

Koppers, Adam John. “Significance of mitochondrial reactive oxygen species production in male infertility.” 2010. Doctoral Dissertation, University of Newcastle. Accessed January 22, 2021. http://hdl.handle.net/1959.13/804406.

MLA Handbook (7^th Edition):

Koppers, Adam John. “Significance of mitochondrial reactive oxygen species production in male infertility.” 2010. Web. 22 Jan 2021.

Vancouver:

Koppers AJ. Significance of mitochondrial reactive oxygen species production in male infertility. [Internet] [Doctoral dissertation]. University of Newcastle; 2010. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1959.13/804406.

Council of Science Editors:

Koppers AJ. Significance of mitochondrial reactive oxygen species production in male infertility. [Doctoral Dissertation]. University of Newcastle; 2010. Available from: http://hdl.handle.net/1959.13/804406

16. Kichine, Elsa. Spermiogenèse et infertilité masculine : étude des transcrits du gène UBA1, codant pour l'enzyme activatrice de l'ubiquitine et évaluation génétique de deux variants dans le gène PRM1 codant pour la protamine1 : Spermiogenesis and male infertility : study of transcripts from UBA1, the gene coding the ubiquitin activating enzyme, and genetic evaluation of two variants in PRM1, the gene coding protamine1.

Degree: Docteur es, Pathologie humaine, 2010, Aix-Marseille 2

URL: http://www.theses.fr/2010AIX20677

►

Les gènes du chromosomeX sont majoritairement inactivés au cours de la méiose mâle. Chez la souris, seulement 6% d’entre eux sont réactivés au cours des… (more)

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Les gènes du chromosomeX sont majoritairement inactivés au cours de la méiose mâle. Chez la souris, seulement 6% d’entre eux sont réactivés au cours des stades post-méiotiques. Parmi eux le gène Uba1X codant pour l’enzyme activatrice de l'ubiquitine, UBA1 qui produit trois transcrits dont deux sont ubiquitaires mais le troisième prédomine dans les cellules post¬-méiotiques : les spermatides. Nos travaux montrent que les 5’UTR, seul différence entre ces trois transcrits, déterminent la localisation et la dose relative des isoformes nucléaire et cytoplasmique de la protéine UBA1. Nous avons mis en évidence chez la souris que le transcrit spermatide-spécifique code pour l'isoforme nucléaire, exprimée fortement dans les spermatides suggérant un rôle de la protéine UBA1 dans la dégradation des histones lors du remodelage chromatinien. Nous avons détecté deux mutations dans la région spermatide-spécifique du gène : une délétion de 13pb et une transition G>A, chacune portée par un patient infertile, et non retrouvée dans notre population témoin. Les analyses ont montré que la délétion de 13pb induit un épissage anormal du transcrit spermatide-spécifique et que la transition G>A pouvait réduire le taux d’expression du transcrit spermatide-spécifique. Ces mutations pourraient induire l'infertilité des deux patients. En parallèle nous avons pu démontrer que les mutations dans le gène codant pour la protamine PRM1 décrites dans la littérature c.102G>T et c.-107G>C ne sont pas liées à l'infertilité masculine et que le variant est un polymorphisme fréquemment retrouvé dans la population congolaise.

The majority of genes on the X chromosome are repressed during meiosis and only 6% of them are expressed in post meiotic germ cells. One of these genes is Ubal, encoding the ubiquitin-activating enzyme UBA1. Ubal produces three different transcripts, two of which are ubiquitously expressed while the third is predominant in the post meiotic germ cells: the spermatids. Our study shows that the 5’UTR, which is the only difference between these transcripts, determines the localization and the relative dose of the nuclear and cytoplasmic isoform of the UBA1 protein. The spermatid-specific transcript encodes for the nuclear isoform in the spermatids in the mouse suggesting that the UBA1 protein is implicated in chromatin remodeling during spermiogenesis. We have detected two mutations in the spermatid-specific region of the UBA1 gene in two infertile men: a deletion of 13bp and a G>A transition, neither of which was found in our cohort of fertile men. The deletion of 13bp diminishes the correct splicing of the spermatid-specific transcript and that the G>A transition may reduce expression of the spermatid-specific transcript. These results show that the UBA1 gene is involved in spermiogenesis, and reactivated in spermatids by its spermatid-specific transcript and that the mutations identified may induce infertility by reducing UBA1 levels in spermatids. We have also demonstrated that two variants described in the protamine codant gene…

Advisors/Committee Members: Mitchell, Michaẽl (thesis director).

Subjects/Keywords: Spermiogenèse; Infertilité masculine; Ubiquitine; Protamine; Spermiogenesis; Male infertility; Ubiquitin; Protamines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kichine, E. (2010). Spermiogenèse et infertilité masculine : étude des transcrits du gène UBA1, codant pour l'enzyme activatrice de l'ubiquitine et évaluation génétique de deux variants dans le gène PRM1 codant pour la protamine1 : Spermiogenesis and male infertility : study of transcripts from UBA1, the gene coding the ubiquitin activating enzyme, and genetic evaluation of two variants in PRM1, the gene coding protamine1. (Doctoral Dissertation). Aix-Marseille 2. Retrieved from http://www.theses.fr/2010AIX20677

Chicago Manual of Style (16^th Edition):

Kichine, Elsa. “Spermiogenèse et infertilité masculine : étude des transcrits du gène UBA1, codant pour l'enzyme activatrice de l'ubiquitine et évaluation génétique de deux variants dans le gène PRM1 codant pour la protamine1 : Spermiogenesis and male infertility : study of transcripts from UBA1, the gene coding the ubiquitin activating enzyme, and genetic evaluation of two variants in PRM1, the gene coding protamine1.” 2010. Doctoral Dissertation, Aix-Marseille 2. Accessed January 22, 2021. http://www.theses.fr/2010AIX20677.

MLA Handbook (7^th Edition):

Kichine, Elsa. “Spermiogenèse et infertilité masculine : étude des transcrits du gène UBA1, codant pour l'enzyme activatrice de l'ubiquitine et évaluation génétique de deux variants dans le gène PRM1 codant pour la protamine1 : Spermiogenesis and male infertility : study of transcripts from UBA1, the gene coding the ubiquitin activating enzyme, and genetic evaluation of two variants in PRM1, the gene coding protamine1.” 2010. Web. 22 Jan 2021.

Vancouver:

Kichine E. Spermiogenèse et infertilité masculine : étude des transcrits du gène UBA1, codant pour l'enzyme activatrice de l'ubiquitine et évaluation génétique de deux variants dans le gène PRM1 codant pour la protamine1 : Spermiogenesis and male infertility : study of transcripts from UBA1, the gene coding the ubiquitin activating enzyme, and genetic evaluation of two variants in PRM1, the gene coding protamine1. [Internet] [Doctoral dissertation]. Aix-Marseille 2; 2010. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2010AIX20677.

Council of Science Editors:

Kichine E. Spermiogenèse et infertilité masculine : étude des transcrits du gène UBA1, codant pour l'enzyme activatrice de l'ubiquitine et évaluation génétique de deux variants dans le gène PRM1 codant pour la protamine1 : Spermiogenesis and male infertility : study of transcripts from UBA1, the gene coding the ubiquitin activating enzyme, and genetic evaluation of two variants in PRM1, the gene coding protamine1. [Doctoral Dissertation]. Aix-Marseille 2; 2010. Available from: http://www.theses.fr/2010AIX20677

University of Wisconsin – Oshkosh

17. Laughlin, Tiffany L. The Experience of infertility from the male perspective.

Degree: MS, Nursing-Family Nurse Practitioner, 2011, University of Wisconsin – Oshkosh

URL: http://digital.library.wisc.edu/1793/54080

►

A Clinical Paper submitted in partial fulfillment of the requirements for the degree of Master of Science in Nursing-Family Nurse Practitioner

Infertility is estimated to… (more)

Subjects/Keywords: Men - Health and hygiene; Human reproduction; Infertility, Male

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APA (6^th Edition):

Laughlin, T. L. (2011). The Experience of infertility from the male perspective. (Masters Thesis). University of Wisconsin – Oshkosh. Retrieved from http://digital.library.wisc.edu/1793/54080

Chicago Manual of Style (16^th Edition):

Laughlin, Tiffany L. “The Experience of infertility from the male perspective.” 2011. Masters Thesis, University of Wisconsin – Oshkosh. Accessed January 22, 2021. http://digital.library.wisc.edu/1793/54080.

MLA Handbook (7^th Edition):

Laughlin, Tiffany L. “The Experience of infertility from the male perspective.” 2011. Web. 22 Jan 2021.

Vancouver:

Laughlin TL. The Experience of infertility from the male perspective. [Internet] [Masters thesis]. University of Wisconsin – Oshkosh; 2011. [cited 2021 Jan 22]. Available from: http://digital.library.wisc.edu/1793/54080.

Council of Science Editors:

Laughlin TL. The Experience of infertility from the male perspective. [Masters Thesis]. University of Wisconsin – Oshkosh; 2011. Available from: http://digital.library.wisc.edu/1793/54080

Tampere University

18. Salama, Milla. Ikuisesti kahdestaan – tahaton lapsettomuus ja sosiaalinen tuki miesten kokemana .

Degree: 2019, Tampere University

URL: https://trepo.tuni.fi/handle/10024/116957

► Miesten kokemuksia tahattomasta lapsettomuudesta on tutkittu vähän. Tutkimusta on tehty enemmän naisten tai pariskuntien kokemuksista, jolloin miesten kuvaamat kokemukset ovat jääneet niukoiksi. Isän ja miehen… (more)

▼ Miesten kokemuksia tahattomasta lapsettomuudesta on tutkittu vähän. Tutkimusta on tehty enemmän naisten tai pariskuntien kokemuksista, jolloin miesten kuvaamat kokemukset ovat jääneet niukoiksi. Isän ja miehen rooli perheessä on muuttunut muiden yhteiskunnallisten muutosten myötä, eikä isäksi tulemista nähdä enää vain perheen jatkamisen välttämättömyytenä, vaan toiveena isäksi tulemisesta. Tämän pro gradu -tutkielman tarkoituksen oli tutkia miesten kokemuksia tahattomasta lapsettomuudesta, sen seurauksista sekä sosiaalisesta tuesta. Tutkimus on osa Tampereen yliopiston lapsettomuushanketta. Empiirisen tutkimuksen aineisto kerättiin syksyllä 2018 sähköisellä e-lomakkeella. Lomake sisälsi taustatietoja kartoittavia strukturoituja sekä avoimia kysymyksiä liittyen lapsettomuuden kokemuksiin ja sosiaaliseen tukeen. Viisi e-lomakkeeseen vastanneesta miehestä antoi yhteystietonsa ja luvan jatkohaastattelua varten. Puhelinhaastattelut tehtiin joulukuussa 2018. Tämän tutkielman aineisto muodostui e-lomakkeen vastauksista (n=12) ja puhelimitse toteutetuista teemahaastatteluista (n=3). Tutkimusaineisto analysointiin aineistolähtöisellä sisällönanalyysillä. Miehet kokivat tahattoman lapsettomuuden raskaana emotionaalisena prosessina, johon liittyi tunteiden käsittelyn haasteita. Miehen rooli lapsettomuudessa nähtiin ristiriitaisena, sillä yhteiskunnallisesti rakennetut stereotyyppiset roolit vaikuttivat miehen omiin, mutta myös muiden odotuksiin miehen toiminnasta puolison rinnalla. Miehet kyseenalaistivat asetetut rooliodotukset ja pyrkivät tasa-arvoistamaan lapsettomuuden kokemusta naisten rinnalla. Lapsettomuushoidot koettiin uuvuttaviksi ja kokemukset hoidon laadusta olivat ristiriitaisia. Osa miehistä koki itsensä täysin ulkopuoliseksi lapsettomuushoidoissa, joissa kaikki huomio kiinnitettiin puolisoon. Muut ihmiset kohtasivat lapsettoman miehen myötätuntoisesti, mutta valitettavan usein kohtaamiseen liittyi ajattelematon ja ymmärtämätön suhtautuminen, joka johti lapsettomuuden salailemiseen. Lapsettomuus aiheutti henkistä kasvua ja elämän tuomiin muutoksiin opettelemista. Miehet saivat monipuolista tukea laajalta tukiverkolta, ja puolison tuki vertaistuen ohella koettiin elintärkeäksi. Miehet jäivät kaipaamaan ystävien rohkeaa kohtaamista sekä kokonaisvaltaisesti pariskunnan huomioivaa hoitohenkilökunnan informatiivista tukea. Hoitohenkilökunnan toivottiin ohjaavan pariskuntia vertaistuen ja muiden tukipalveluiden äärelle. Johtopäätöksenä voidaan todeta, että lapsettomuudesta kärsivät miehet tarvitsevat tasa-arvoista huomiota sekä rooliodotuksia rikkovaa tukea kaikilla yhteiskunnan sosiaalisten suhteiden tasoilla. Hoidossa huomiota tulisi kiinnittää pariskuntien yksilöllisiin tarpeisiin ja miesten tunteiden käsittelyyn. Tämän tutkimuksen tulosten avulla voidaan kehittää tuki-interventiomenetelmää lapsettomuudesta kärsiville miehille ja pariskunnille.

Subjects/Keywords: lapsettomuus; miesnäkökulma; sosiaalinen tuki; Infertility; Childlessness; Male; Social Support

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APA (6^th Edition):

Salama, M. (2019). Ikuisesti kahdestaan – tahaton lapsettomuus ja sosiaalinen tuki miesten kokemana . (Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/116957

Chicago Manual of Style (16^th Edition):

Salama, Milla. “Ikuisesti kahdestaan – tahaton lapsettomuus ja sosiaalinen tuki miesten kokemana .” 2019. Masters Thesis, Tampere University. Accessed January 22, 2021. https://trepo.tuni.fi/handle/10024/116957.

MLA Handbook (7^th Edition):

Salama, Milla. “Ikuisesti kahdestaan – tahaton lapsettomuus ja sosiaalinen tuki miesten kokemana .” 2019. Web. 22 Jan 2021.

Vancouver:

Salama M. Ikuisesti kahdestaan – tahaton lapsettomuus ja sosiaalinen tuki miesten kokemana . [Internet] [Masters thesis]. Tampere University; 2019. [cited 2021 Jan 22]. Available from: https://trepo.tuni.fi/handle/10024/116957.

Council of Science Editors:

Salama M. Ikuisesti kahdestaan – tahaton lapsettomuus ja sosiaalinen tuki miesten kokemana . [Masters Thesis]. Tampere University; 2019. Available from: https://trepo.tuni.fi/handle/10024/116957

Harvard University

19. Schilit, Samantha Linn Price. Uncovering Novel Cytogenetic and Molecular Etiologies for Male Infertility.

Degree: PhD, 2019, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029538

►

Infertility affects 10-15% of couples, making it one of the most frequent health disorders for reproductive aged individuals. Over 20% of cases are idiopathic, and… (more)

▼

Infertility affects 10-15% of couples, making it one of the most frequent health disorders for reproductive aged individuals. Over 20% of cases are idiopathic, and it is commonly thought that many individuals have an underlying genetic etiology. Identifying genes involved in unexplained infertility provides information to support diagnosis, genetic counseling and potential therapeutic intervention. One approach to identifying genes involved in infertility is to examine the phenotype-genotype correlation in subjects with a clinical phenotype accompanied by a balanced chromosomal aberration (BCA), as is the foundation of gene discovery in the Developmental Genome Anatomy Project (DGAP). Participant DGAP230 has severe oligospermia and 46,XY,t(20;22)(q13.3;q11.2). While BCAs may reduce fertility by production of unbalanced gametes, a chromosomal rearrangement may also disrupt or dysregulate genes important in fertility. Using large-insert genome sequencing, chromosomal breakpoints were determined with nucleotide-level precision. Investigation of genes in the topologically associated domains at the sites of the rearrangement and subsequent use of the novel 3C-PCR technique revealed exclusive dysregulation of synaptonemal complex protein 2 (SYCP2) from the derivative chromosome 20 (der(20)) allele, which resides 1.5 Mb centromeric to the der(20) breakpoint. 4C-seq from the SYCP2 promoter revealed interactions eight Mb downstream of the der(20) breakpoint in chromosome 22, supporting a model of enhancer adoption. SYCP2 encodes synaptonemal complex protein 2, a member of the synaptonemal complex involved in male meiosis I homologous chromosome synapsis. To assess its impact on meiosis, we misexpressed RED1, the functional axial element homolog of SYCP2 in Saccharomyces cerevisiae. By performing Red1 immunolocalization on surface-spread meiotic nuclei, we discovered that excess Red1 forms polycomplexes, disrupting the structural integrity of the synaptonemal complex by preventing incorporation of the transverse filament Zip1. This model highlights aberrant meiosis as the defect in spermatogenesis leading to severe oligospermia. Finally, we reveal two novel frameshift mutations in SYCP2 identified in azoospermic men, which further support a mechanism of SYCP2-mediated infertility. This thesis provides the first evidence of SYCP2-mediated infertility in humans and illuminates that rearrangement breakpoints should be considered as an alternative etiology to that of segregation of unbalanced gametes in infertile men harboring BCAs.

Medical Sciences

Advisors/Committee Members: Kucherlapati, Raju (advisor), Kuroda, Mitzi (committee member), Meselson, Matthew (committee member), Siegfried, Kellee (committee member).

Subjects/Keywords: male infertility; balanced chromosomal aberrations; cytogenetics; synaptonemal complex; SYCP2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schilit, S. L. P. (2019). Uncovering Novel Cytogenetic and Molecular Etiologies for Male Infertility. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029538

Chicago Manual of Style (16^th Edition):

Schilit, Samantha Linn Price. “Uncovering Novel Cytogenetic and Molecular Etiologies for Male Infertility.” 2019. Doctoral Dissertation, Harvard University. Accessed January 22, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029538.

MLA Handbook (7^th Edition):

Schilit, Samantha Linn Price. “Uncovering Novel Cytogenetic and Molecular Etiologies for Male Infertility.” 2019. Web. 22 Jan 2021.

Vancouver:

Schilit SLP. Uncovering Novel Cytogenetic and Molecular Etiologies for Male Infertility. [Internet] [Doctoral dissertation]. Harvard University; 2019. [cited 2021 Jan 22]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029538.

Council of Science Editors:

Schilit SLP. Uncovering Novel Cytogenetic and Molecular Etiologies for Male Infertility. [Doctoral Dissertation]. Harvard University; 2019. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029538

Hong Kong University of Science and Technology

20. Xiao, Nan. Role of PICK1 in acrosome formation and male fertility.

Degree: 2009, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-6203 ; https://doi.org/10.14711/thesis-b1070232 ; http://repository.ust.hk/ir/bitstream/1783.1-6203/1/th_redirect.html

► Protein interacting with C kinase 1 (PICK1) is a higly conserved peripheral membrane protein involved in protein trafficking, a function that has been well characterized… (more)

Subjects/Keywords: Spermatogenesis ; Protein kinases ; Infertility, Male

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APA (6^th Edition):

Xiao, N. (2009). Role of PICK1 in acrosome formation and male fertility. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-6203 ; https://doi.org/10.14711/thesis-b1070232 ; http://repository.ust.hk/ir/bitstream/1783.1-6203/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xiao, Nan. “Role of PICK1 in acrosome formation and male fertility.” 2009. Thesis, Hong Kong University of Science and Technology. Accessed January 22, 2021. http://repository.ust.hk/ir/Record/1783.1-6203 ; https://doi.org/10.14711/thesis-b1070232 ; http://repository.ust.hk/ir/bitstream/1783.1-6203/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xiao, Nan. “Role of PICK1 in acrosome formation and male fertility.” 2009. Web. 22 Jan 2021.

Vancouver:

Xiao N. Role of PICK1 in acrosome formation and male fertility. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2009. [cited 2021 Jan 22]. Available from: http://repository.ust.hk/ir/Record/1783.1-6203 ; https://doi.org/10.14711/thesis-b1070232 ; http://repository.ust.hk/ir/bitstream/1783.1-6203/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xiao N. Role of PICK1 in acrosome formation and male fertility. [Thesis]. Hong Kong University of Science and Technology; 2009. Available from: http://repository.ust.hk/ir/Record/1783.1-6203 ; https://doi.org/10.14711/thesis-b1070232 ; http://repository.ust.hk/ir/bitstream/1783.1-6203/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington

21. Amory, John Kenneth. Isotretinoin Administration Improves Sperm Production in Men with Infertility.

Degree: 2017, University of Washington

URL: http://hdl.handle.net/1773/40669

► University of Washington Abstract Isotretinoin Administration Improves Sperm Production in Men with Infertility John K. Amory MD, MPH Chair of the Supervisory Committee: Dr. Nina… (more)

Subjects/Keywords: Male infertility; retinoic acid; spermatogenesis; Pharmaceutical sciences; Pharmaceutics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Amory, J. K. (2017). Isotretinoin Administration Improves Sperm Production in Men with Infertility. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/40669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Amory, John Kenneth. “Isotretinoin Administration Improves Sperm Production in Men with Infertility.” 2017. Thesis, University of Washington. Accessed January 22, 2021. http://hdl.handle.net/1773/40669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Amory, John Kenneth. “Isotretinoin Administration Improves Sperm Production in Men with Infertility.” 2017. Web. 22 Jan 2021.

Vancouver:

Amory JK. Isotretinoin Administration Improves Sperm Production in Men with Infertility. [Internet] [Thesis]. University of Washington; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1773/40669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Amory JK. Isotretinoin Administration Improves Sperm Production in Men with Infertility. [Thesis]. University of Washington; 2017. Available from: http://hdl.handle.net/1773/40669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Leur, Sjef. Mannelijke infertiliteit en in-vitro-fertilisatie.

Degree: 1993, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/39462

► textabstractThis thesis describes the treatment of male infertility by in-vitro-fertilization. IVF was a treatment for infertility caused by tubal blockage. Thereafter IVF was also used… (more)

▼ textabstractThis thesis describes the treatment of male infertility by in-vitro-fertilization. IVF was a treatment for infertility caused by tubal blockage. Thereafter IVF was also used as a treatment for male infertility.IVF is the bringing together of the gametes outside the female body. After fertilization the embryo is cultured in an incubator before it will be transplanted to the uterus. The process of development of the gametes and fertilization is described in chapter 1 of this thesis. A mature sperm and oocyte are formed after mitotic and meiotic divisions. The head of the spermatozoa is covered by the acrosome. During passage of the cumulus and the zona pellucida of the oocyte, the acrosome loses its enzymes, the acrosomal reaction. By means of the enzymatic action of the acrosomal proteins and the mechanical force of the beating sperm tail, the sperm penetrates the zona pellu· cida. After contact of the sperm with the cell membrane of the oocyte, the membranes fuse and the oocyte completes its second meiotic division. After this process the embryo is formed. The history of the discovery of the gametes and fertilization and the first successful attempt to achieve a fertilization in-vitro are described in chapter 2. It was only from the beginning of the seventies that it was possible to culture human embryos in· vitro. Since so many patients today are treated by IVF it is possible to compare the results of different groups of patients. In chapter 3 the results of IVF for male infertility on the IVF-laboratory of the Dijkzigt Hospital are described. Patients were grouped according to the concentration of motile sperm in the ejaculate. Seven groups were formed, on a logarithmic ascending scale. Results were studied per ovum pick-up and per patient. Ovum pick-ups with a low sperm concentration did have a lower fertilization rate (total number of punctures with fertilization/total number of punctures in that group) than punctures with a high sperm concentration. Punctures with a concen· tration of motile sperm oflxl06/ml had a fertilization rate of34%, in the group with 4-8x106/ml the fertilization rate was 69% and in the groups with the highest concentrations the fertilization rate was 90% per ovum pick-up. After fertilization had been achieved the percentage of pregnancy was the same for all groups. Other criteria to determine quality of embryo's, such as the number of morphologically good embry· o's being transplanted or the possibility of cryopreservation showed no difference between the sperm groups

Subjects/Keywords: in-vitro fertilization; infertility; male

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leur, S. (1993). Mannelijke infertiliteit en in-vitro-fertilisatie. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/39462

Chicago Manual of Style (16^th Edition):

Leur, Sjef. “Mannelijke infertiliteit en in-vitro-fertilisatie.” 1993. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 22, 2021. http://hdl.handle.net/1765/39462.

MLA Handbook (7^th Edition):

Leur, Sjef. “Mannelijke infertiliteit en in-vitro-fertilisatie.” 1993. Web. 22 Jan 2021.

Vancouver:

Leur S. Mannelijke infertiliteit en in-vitro-fertilisatie. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1993. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1765/39462.

Council of Science Editors:

Leur S. Mannelijke infertiliteit en in-vitro-fertilisatie. [Doctoral Dissertation]. Erasmus University Medical Center; 1993. Available from: http://hdl.handle.net/1765/39462

University of the Western Cape

23. Fortuin, Kay Arlene. Analyses of spermatozoa surface proteins using different separation techniques .

Degree: 2013, University of the Western Cape

URL: http://hdl.handle.net/11394/4607

► Passage of spermatozoa through the female reproductive tract is essential for the regulation of fertilization, ensuring that healthy sperm reach the oocyte. Previous studies were… (more)

▼ Passage of spermatozoa through the female reproductive tract is essential for the regulation of fertilization, ensuring that healthy sperm reach the oocyte. Previous studies were devoted to morphological selection of sperm cells by the cervical mucus. However, research prove that the loss of integrity of the sperm plasma membrane is associated with infertile men, irrespective of their normal semen parameters. This indicates that the sperm plasma membrane plays an important role in fertilization. Further studies indicated that sperm surface proteins assist penetration through the female reproductive tract and would therefore provide useful insight in understanding other factors associated with male infertility. The aim of this project was to determine if there are any differences between sperm surface proteins of fertile donor samples in relation to infertile patient samples using different separation techniques and different detergents. Three different sperm separation techniques were employed, including wash, swim-up (SU) and Percoll density gradient centrifugation (DGC).Parallel to this, the deoxy-ribose nucleic acid (DNA) fragmentation of these cells were analysed for comparison of the extent of DNA damage induced due to different separation techniques used. This provided evidence that the best separation technique is the DGC as it minimises the amount of DNA fragmentation caused. Four different detergents were used in the process of extracting the membrane proteins from spermatozoa, namely sodium dodecyl sulphate (SDS), saponin,cetyl-trimethyl-ammonium bromide (CTAB), and TWEEN-20. The membrane proteins were then separated on a12% SDS poly-acrylamide gel electrophoresis (PAGE), and analysed by Coomassie blue and silver staining techniques as well as densitometry. Due to the different chemical nature of the detergents that extracted different surface proteins, CTAB (cationic) and SDS (anionic) extracted the most because of its strong solubilising abilities as non-ionic detergents. Common proteins that were extracted in donor samples included; 115, 92.5, 89, 61, 55.5, 51.5, 47, 44.5, 43, 38.5, 34 and 28 kDa proteins. In patients, commonly occurring proteins included; 92.5, 74.5, 70, 60.5, 51.5, 50, 44.5, 43, 36, 29.5, and 25.5 kDa proteins. Marked differences were found between membrane proteins extracted from donor samples in comparison to patient samples. Identification of these proteins was done using the SwissProt database and a literature search. Mostly non-genomic progesterone receptors were identified; others included oestrogen receptor, a phosphotyrosyl protein, P34H, equatorial segment protein, mannose lectin receptor, human guanylylcyclase receptor, epididymal protease inhibitor receptor, PH30 and estradiol binding protein. The function of the membrane surface proteins identified in this study plays a vital role in fertilization. A few of these functions include sperm attachment and binding to the oocyte as well as penetration thereof. Others play a role in signalling events such as capacitation,… Advisors/Committee Members: Henkel, Ralph (advisor), Menkveld, Rudolf (advisor).

Subjects/Keywords: Male infertility; Human sperm membrane proteins; Sperm separation techniques

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fortuin, K. A. (2013). Analyses of spermatozoa surface proteins using different separation techniques . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/4607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fortuin, Kay Arlene. “Analyses of spermatozoa surface proteins using different separation techniques .” 2013. Thesis, University of the Western Cape. Accessed January 22, 2021. http://hdl.handle.net/11394/4607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fortuin, Kay Arlene. “Analyses of spermatozoa surface proteins using different separation techniques .” 2013. Web. 22 Jan 2021.

Vancouver:

Fortuin KA. Analyses of spermatozoa surface proteins using different separation techniques . [Internet] [Thesis]. University of the Western Cape; 2013. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11394/4607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fortuin KA. Analyses of spermatozoa surface proteins using different separation techniques . [Thesis]. University of the Western Cape; 2013. Available from: http://hdl.handle.net/11394/4607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

24. Schiza, Christina. Preclinical Evaluation of TEX101 Protein as a Male Infertility Biomarker and Identification of its Functional Interactome.

Degree: PhD, 2017, University of Toronto

URL: http://hdl.handle.net/1807/80965

► TEX101 is a testis-specific cell surface protein expressed exclusively in the male germ cells, and it was previously suggested as a biomarker for the differential… (more)

Subjects/Keywords: Biomarkers; Human Reproduction; Interactome; Male Infertility; Testis expressed protein 101; 0307

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schiza, C. (2017). Preclinical Evaluation of TEX101 Protein as a Male Infertility Biomarker and Identification of its Functional Interactome. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/80965

Chicago Manual of Style (16^th Edition):

Schiza, Christina. “Preclinical Evaluation of TEX101 Protein as a Male Infertility Biomarker and Identification of its Functional Interactome.” 2017. Doctoral Dissertation, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/80965.

MLA Handbook (7^th Edition):

Schiza, Christina. “Preclinical Evaluation of TEX101 Protein as a Male Infertility Biomarker and Identification of its Functional Interactome.” 2017. Web. 22 Jan 2021.

Vancouver:

Schiza C. Preclinical Evaluation of TEX101 Protein as a Male Infertility Biomarker and Identification of its Functional Interactome. [Internet] [Doctoral dissertation]. University of Toronto; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/80965.

Council of Science Editors:

Schiza C. Preclinical Evaluation of TEX101 Protein as a Male Infertility Biomarker and Identification of its Functional Interactome. [Doctoral Dissertation]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/80965

25. Lawson, Michele. Male Infertility: The Process to Seeking Treatment.

Degree: PhD, Nursing Science, 2016, Texas Woman's University

URL: http://hdl.handle.net/11274/9614

► nfertility has an effect on both males and females. Current literature focuses on women rather than men. The purpose of this study was to gain… (more)

Subjects/Keywords: Health and environmental sciences; Grounded theory; Infertility; Male factor; Seeking treatment

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APA (6^th Edition):

Lawson, M. (2016). Male Infertility: The Process to Seeking Treatment. (Doctoral Dissertation). Texas Woman's University. Retrieved from http://hdl.handle.net/11274/9614

Chicago Manual of Style (16^th Edition):

Lawson, Michele. “Male Infertility: The Process to Seeking Treatment.” 2016. Doctoral Dissertation, Texas Woman's University. Accessed January 22, 2021. http://hdl.handle.net/11274/9614.

MLA Handbook (7^th Edition):

Lawson, Michele. “Male Infertility: The Process to Seeking Treatment.” 2016. Web. 22 Jan 2021.

Vancouver:

Lawson M. Male Infertility: The Process to Seeking Treatment. [Internet] [Doctoral dissertation]. Texas Woman's University; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11274/9614.

Council of Science Editors:

Lawson M. Male Infertility: The Process to Seeking Treatment. [Doctoral Dissertation]. Texas Woman's University; 2016. Available from: http://hdl.handle.net/11274/9614

University of Debrecen

26. Keren, Daria. Endocrinological treatment in male infertility .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/281196

► In this work, I lay down the anatomical and embryological development of the male gonads and genitalia, reviewing the pathomechanisms of the fertility diseases. The… (more)

Subjects/Keywords: Hormonal therpay; Male infertility; Hypogonadism

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APA (6^th Edition):

Keren, D. (n.d.). Endocrinological treatment in male infertility . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/281196

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Keren, Daria. “Endocrinological treatment in male infertility .” Thesis, University of Debrecen. Accessed January 22, 2021. http://hdl.handle.net/2437/281196.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Keren, Daria. “Endocrinological treatment in male infertility .” Web. 22 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Keren D. Endocrinological treatment in male infertility . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2437/281196.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Keren D. Endocrinological treatment in male infertility . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/281196

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Southern California

27. Houshdaran, Sahar. DNA methylation as a biomarker in human reproductive health and disease.

Degree: PhD, Biochemistry & Molecular Biology, 2011, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/254394/rec/2068

► Epigenetics refers to the changes in gene expression that are not accounted for by the changes in DNA sequence. DNA methylation is one of the… (more)

Subjects/Keywords: DNA methylation; epigenetics; ovarian cancer; ovarian carcinoma; male infertility; sperm epigenetics

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APA (6^th Edition):

Houshdaran, S. (2011). DNA methylation as a biomarker in human reproductive health and disease. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/254394/rec/2068

Chicago Manual of Style (16^th Edition):

Houshdaran, Sahar. “DNA methylation as a biomarker in human reproductive health and disease.” 2011. Doctoral Dissertation, University of Southern California. Accessed January 22, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/254394/rec/2068.

MLA Handbook (7^th Edition):

Houshdaran, Sahar. “DNA methylation as a biomarker in human reproductive health and disease.” 2011. Web. 22 Jan 2021.

Vancouver:

Houshdaran S. DNA methylation as a biomarker in human reproductive health and disease. [Internet] [Doctoral dissertation]. University of Southern California; 2011. [cited 2021 Jan 22]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/254394/rec/2068.

Council of Science Editors:

Houshdaran S. DNA methylation as a biomarker in human reproductive health and disease. [Doctoral Dissertation]. University of Southern California; 2011. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/254394/rec/2068

University of Southern California

28. Davis-Dao, Carol Ann. The role of steroid hormones in the etiology of urologic diseases.

Degree: PhD, Epidemiology, 2011, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/427923/rec/7263

► One of the main goals of my doctoral training has been to gain experience working with a variety of types of epidemiologic data. The three… (more)

▼ One of the main goals of my doctoral training has been to gain experience working with a variety of types of epidemiologic data. The three projects that compose this dissertation have provided me with the opportunity to work with several different data structures: (1) published summary data, (2) population-based family data, (3) prospective cohort data, and (4) population-based case-control data.; For my dissertation, I have employed each of these data structures to investigate the role of steroid hormones in the etiology of several urologic diseases. In the last several decades of epidemiologic research, it has become clear that steroid hormones are involved in many disease processes. For my research, I have studied the relationships between steroid hormone exposure and molecules of steroid hormone response and female bladder cancer, as well as two male urologic diseases: infertility and testicular germ cell tumors.; In my first paper, I investigated the association between male infertility and a polymorphic CAG repeat tract in the androgen receptor gene (AR) through the meta-analysis of a large body of existing literature on the topic. I quantitatively summarized 33 studies, and found that infertile male cases had statistically significantly longer mean CAG repeat length than controls (SMD: 0.19, 95% CI: 0.09-0.29). Meta-analysis of a select subset of 13 studies that used more stringent case and control selection criteria revealed a larger difference between cases and controls (SMD: 0.31, 95% CI: 0.14-0.47). This meta-analysis provides support for an association between increased androgen receptor CAG length and idiopathic male infertility, and brings together for the first time results from many published reports on this topic.; In my second paper, I expanded upon the results of the meta-analysis to conduct an original data analysis studying the association between androgen receptor CAG repeat length and risk of testicular germ cell tumors. Increasing rates of testicular germ cells tumors (TGCTs) over the last 40 years suggest environmental factors are involved in disease etiology, but familial risk studies indicate that genetic factors are also important.; I investigated whether variation in CAG trinucleotide repeat length in exon 1 of the androgen receptor gene is associated with TGCTs using data from a population-based family study. Analyses of 273 TGCT case-mother pairs revealed no association between androgen receptor CAG repeat length and overall risk of TGCTs. Risk of seminoma was significantly associated with shorter CAG repeat length, and the trend was highly significant over decreasing CAG repeat length (CAG ≥20 versus CAG ≤19: OR=0.54 (95% CI: 0.31-0.93), p trend=0.003). Case-case analyses comparing seminoma cases to nonseminoma and mixed germ cell tumors confirmed that seminoma cases had shorter CAG repeat length than other histologies (CAG ≥20 versus CAG ≤19: OR=0.54 (95%CI: 0.29-1.01), p trend=0.003).; My findings indicate that the AR may be involved in progression from CIS to seminoma and that… Advisors/Committee Members: Cortessis, Victoria K. (Committee Chair), Azen, Stanley Paul (Committee Member), McKean-Cowdin, Roberta (Committee Member), Siegmund, Kimberly D. (Committee Member), Coetzee, Gerhard A. (Committee Member).

Subjects/Keywords: hormones; male infertility; testicular germ cell tumors; bladder cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Davis-Dao, C. A. (2011). The role of steroid hormones in the etiology of urologic diseases. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/427923/rec/7263

Chicago Manual of Style (16^th Edition):

Davis-Dao, Carol Ann. “The role of steroid hormones in the etiology of urologic diseases.” 2011. Doctoral Dissertation, University of Southern California. Accessed January 22, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/427923/rec/7263.

MLA Handbook (7^th Edition):

Davis-Dao, Carol Ann. “The role of steroid hormones in the etiology of urologic diseases.” 2011. Web. 22 Jan 2021.

Vancouver:

Davis-Dao CA. The role of steroid hormones in the etiology of urologic diseases. [Internet] [Doctoral dissertation]. University of Southern California; 2011. [cited 2021 Jan 22]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/427923/rec/7263.

Council of Science Editors:

Davis-Dao CA. The role of steroid hormones in the etiology of urologic diseases. [Doctoral Dissertation]. University of Southern California; 2011. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/427923/rec/7263

29. La Vignera, Sandro Salvuccio Maria. Caratterizzazione ultrasonografica della regione vescicolare in pazienti infertili con neuropatia diabetica.

Degree: 2012, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/971

► La malattia diabetica influenza la capacità riproduttiva maschile. Esistono pochi dati riguardanti gli aspetti morfo-funzionali delle vescicole seminali dei pazienti infertili con diabete mellito. Lo… (more)

▼ La malattia diabetica influenza la capacità riproduttiva maschile. Esistono pochi dati riguardanti gli aspetti morfo-funzionali delle vescicole seminali dei pazienti infertili con diabete mellito. Lo scopo di questo studio è stato valutare le caratteristiche ecografiche delle vescicole seminali di pazienti infertili con diabete tipo 2 e neuropatia. Sono stati selezionati 30 pazienti infertili con neuropatia diabetica e senza altre comorbità andrologiche. Due gruppi di controllo differenti sono stati valutati : uomini non diabetici con infertilità idiopatica (n=30) e pazienti infertili con infiammazione a carico delle ghiandole sessuali accessorie(MAGI) (n=30), un modello clinico di infiammazione a carico delle vescicole seminali ben caratterizzato sul piano nosografico. I pazienti ed i controlli sono stati sottoposti a valutazione ecografica della regione prostato-vescicolare per via transrettale endocavitaria dopo 1 giorno di astinenza sessuale prima e 1 ora dopo atto eiaculatorio. I seguenti parametri ecografici sono stati analizzati: (1,2) spessore intervescicolare rilevato in corrispondenza del corpo e del fondo ghiandolare, (3) spessore parietale vescicolare, (4) numero di aree policicliche endoluminali; (5) rapporto tra lo spessore interparietale rilevato al fondo ed al corpo ghiandolare; (6) differenza di spessore interparietale intervescicolare, (7) differenza dello spessore interparietale ghiandolare prima e dopo atto eiaculatorio. I pazienti con DM mostrarono valori medi del rapporto tra lo spessore interparietale rilevato al fondo ghiandolare rispetto lo spessore interparietale rilevato al corpo significativamente maggiori (p<0.05) rispetto gli altri gruppi. Solo i pazienti con MAGI mostrarono un significativo (p <0,05) aumento del numero di di aree policicliche endoluminali. I controlli ed i pazienti con MAGI mostrarono valori non differenti sul piano statistico relativamente allo spessore interparietale rilevato prima e dopo atto eiaculatorio mentre tale parametro risulto' significativamente (p <0,05) ridotto nei pazienti con diabete mellito. In conclusione, questo studio ha dimostrato che i pazienti infertili con DM hanno peculiari caratteristiche ecografiche SV suggestivi di atonia funzionale.

Subjects/Keywords: Area 06 - Scienze mediche; diabetes; male infertility; neuropathy

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APA (6^th Edition):

La Vignera, S. S. M. (2012). Caratterizzazione ultrasonografica della regione vescicolare in pazienti infertili con neuropatia diabetica. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/971

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

La Vignera, Sandro Salvuccio Maria. “Caratterizzazione ultrasonografica della regione vescicolare in pazienti infertili con neuropatia diabetica.” 2012. Thesis, Università degli Studi di Catania. Accessed January 22, 2021. http://hdl.handle.net/10761/971.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

La Vignera, Sandro Salvuccio Maria. “Caratterizzazione ultrasonografica della regione vescicolare in pazienti infertili con neuropatia diabetica.” 2012. Web. 22 Jan 2021.

Vancouver:

La Vignera SSM. Caratterizzazione ultrasonografica della regione vescicolare in pazienti infertili con neuropatia diabetica. [Internet] [Thesis]. Università degli Studi di Catania; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10761/971.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

La Vignera SSM. Caratterizzazione ultrasonografica della regione vescicolare in pazienti infertili con neuropatia diabetica. [Thesis]. Università degli Studi di Catania; 2012. Available from: http://hdl.handle.net/10761/971

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Condorelli, Rosita Angela. Diabete mellito: "una nuova causa di infertilità".

Degree: 2017, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/3817

► Introduzione: Il diabete mellito (DM) può determinare infertilità maschile agendo a livello pre-testicolare, testicolare e post-testicolare. Scopo della tesi: valutare la presenza di infertilità maschile… (more)

▼ Introduzione: Il diabete mellito (DM) può determinare infertilità maschile agendo a livello pre-testicolare, testicolare e post-testicolare. Scopo della tesi: valutare la presenza di infertilità maschile e i meccanismi di danno spermatico nei pazienti con DM in età fertile. Materiali e Metodi: Sono stati arruolati 34 pazienti con DM1, 55 pazienti con DM2, e 100 soggetti fertili sani controllo normale . I pazienti diabetici sono stati ulteriormente suddivisi in 3 gruppi sulla base del compenso glicometabolico e della durata di malattia. Sono stati eseguiti: esame standard del liquido seminale e valutazione citofluorimetrica dei parametri spermatici non convenzionali (frammentazione del DNA nemaspermico, valutazione del grado di vitalità, apoptosi precoce e apoptosi tardiva e del grado di condensazione cromatinica; studio del potenziale di membrana mitocondriale, MMP), formula leucocitaria nell eiaculato mediante analisi citofluorimetrica, valutazione del grado di perossidazione lipidica (PL), e dei livelli spermatici di superossido mitocondriale, ecografia didimo-epididimaria e determinazione sierica in chemiluminescenza di testosterone totale, LH. Risultati: i pazienti diabetici presentano concentrazione nemaspermica, motilità progressiva e morfologia ridotte rispetto al gruppo di controllo (p<0.05). Il volume dell eiaculato è significativamente inferiore nei pazienti con DM1 (p<0.05), ma sembra non subire variazioni significative nei pazienti con DM2 rispetto al gruppo di controllo. Le concentrazioni di leucociti risultano più elevate solo nei pazienti con DM2 (p<0.05), registrando una riduzione statisticamente significativa della percentuale di linfociti T helper nel liquido seminale e un aumento di quella dei linfociti T suppressor rispetto ai soggetti di controllo (p<0.05) L analisi dei parametri spermatici non convenzionali ha mostrato un peggioramento dell MMP nei pazienti diabetici (p<0.05). Solo i pazienti con DM2 hanno mostrato una riduzione significativa del grado di vitalità nemaspermica con aumento di apoptosi tardiva rispetto al gruppo di controllo e della frammentazione del DNA rispetto agli altri due gruppi (p<0.05). Quando suddivisi per durata di malattia, i pazienti con DM1 presentano una motilità progressiva minore nei casi di lunga (>10 anni) durata di malattia rispetto agli altri due gruppi, accompagnata da basso MMP dopo 5 anni di malattia (p<0.05). Il grado di PL è maggiore nel gruppo con DM2 rispetto agli altri due gruppi (p<0.05), mentre le concentrazioni di superossido mitocondriale risultano maggiori nei diabetici rispetto al gruppo di controllo, e maggiori nel DM2 maggiori rispetto al DM1 (p<0.05). I dati ecografici mostrano che il diametro del caput e della coda dell epididimo dopo eiaculazione sono maggiori rispetto al controllo nei pazienti con DM1 di lunga durata rispetto a quelli di breve durata (p<0.05). I livelli di TT risultano più bassi nei DM2 rispetto al gruppo di controllo (p<0.05). Conclusione: i pazienti con DM1 presentano bassi volumi dell eiaculato per mancato…

Subjects/Keywords: Area 06 - Scienze mediche; diabetes mellitus; sperm parameters; male infertility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Condorelli, R. A. (2017). Diabete mellito: "una nuova causa di infertilità". (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/3817

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Condorelli, Rosita Angela. “Diabete mellito: "una nuova causa di infertilità".” 2017. Thesis, Università degli Studi di Catania. Accessed January 22, 2021. http://hdl.handle.net/10761/3817.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Condorelli, Rosita Angela. “Diabete mellito: "una nuova causa di infertilità".” 2017. Web. 22 Jan 2021.

Vancouver:

Condorelli RA. Diabete mellito: "una nuova causa di infertilità". [Internet] [Thesis]. Università degli Studi di Catania; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10761/3817.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Condorelli RA. Diabete mellito: "una nuova causa di infertilità". [Thesis]. Università degli Studi di Catania; 2017. Available from: http://hdl.handle.net/10761/3817

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations