publisher:("Washington University in St. Louis")

Washington University in St. Louis

1. Cameron, Jeffrey Carlyle. Redox homeostasis in cyanobacteria.

Degree: 2011, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3450787

► Oxygenic photosynthetic organisms utilize high-energy electron transfer chains comprised of redox active intermediates and light harvesting complexes. While oxygen is a necessary byproduct of… (more)

▼ Oxygenic photosynthetic organisms utilize high-energy electron transfer chains comprised of redox active intermediates and light harvesting complexes. While oxygen is a necessary byproduct of water oxidation and the source of photosynthetic electrons, its presence is also dangerous because leakage of electrons and excitation energy can interact with molecular oxygen to generate reactive oxygen species (ROS). Elaborate antioxidant networks and redox buffering systems have evolved to protect photosynthetic organisms from the threat of ROS. Glutathione (GSH) is a multifunctional molecule that is involved in core metabolism, detoxification of xenobiotics and in maintenance of cellular redox poise. The ubiquitous nature of glutathione and its importance to cellular metabolism has been observed in many organisms, however the specific roles of glutathione in photosynthetic organisms are not fully understood. To address these questions, we have generated several mutants in the glutathione biosynthesis and degradation pathways in the model organism Synechocystis sp. PCC 6803 (Synechocystis 6803), an oxygenic photosynthetic cyanobacterium. We utilized targeted homologous recombination to generate deletion mutants of glutamate-cysteine ligase (GshA) and glutathione synthetase (GshB) in Synechocystis 6803. Our results indicate that GshA activity is essential for growth in cyanobacteria because we were unable to isolate a fully segregated Δ gshA deletion mutant. We did isolate a ΔgshB mutant strain that accumulates the biosynthetic intermediate γ-glutamylcysteine (γ-EC) instead of GSH. In this work, I have characterized the physiology of the ΔgshB mutant following environmental, genetic and redox perturbations. The results presented here also shed light on the dynamic nature of the low-molecular weight thiol pool in cyanobacteria. We quantified the levels of cellular thiols in Synechocystis 6803 during exposure to multiple environmental and redox perturbations and found that conditions promoting increased cellular metabolism and increased ROS production, including during high-light treatment and photomixotrophic growth, lead to higher cellular thiol levels. Furthermore, the intracellular pools of thiols decrease when the cell exhibits reduced metabolic capacity during conditions such as nutrient deprivation and dark incubation. Sulfate limitation results in dramatically decreased cellular thiol contents in a short period of time. We found that the ΔgshB strain is sensitive to sulfate limitation and exhibits delayed recovery upon sulfate repletion, indicating that GSH is important for acclimation to sulfate limiting conditions. To facilitate our understanding of GSH degradation in Synechocystis 6803 during sulfate limitation, we generated a mutant lacking γ-glutamyltranspeptidase (Ggt), an enzyme with GSH degradation activity. However, the Δ ggt mutant still exhibited GSH…

Subjects/Keywords: Biology; Botany

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cameron, J. C. (2011). Redox homeostasis in cyanobacteria. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3450787

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cameron, Jeffrey Carlyle. “Redox homeostasis in cyanobacteria.” 2011. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3450787.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cameron, Jeffrey Carlyle. “Redox homeostasis in cyanobacteria.” 2011. Web. 01 Mar 2021.

Vancouver:

Cameron JC. Redox homeostasis in cyanobacteria. [Internet] [Thesis]. Washington University in St. Louis; 2011. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3450787.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cameron JC. Redox homeostasis in cyanobacteria. [Thesis]. Washington University in St. Louis; 2011. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3450787

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

2. Gau, Brian Craig. The advancement of mass spectrometry-based hydroxyl radical protein footprinting| Application of novel analysis methods to model proteins and apolipoprotein E.

Degree: 2011, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3454303

► Fast photochemical oxidation of proteins (FPOP) has shown great promise in the elucidation of the regions of a protein's structure that are changed upon… (more)

▼ Fast photochemical oxidation of proteins (FPOP) has shown great promise in the elucidation of the regions of a protein's structure that are changed upon interaction with other macromolecules, ligands, or by folding. The advantage of this protein footprinting method is that it utilizes the reactivity of hydroxyl radicals to stably modify solvent accessible residues non-specifically in a microsecond. The extent of ·OH labeling at sites assays their solvent accessibility. We have corroborated the predicted profoundly short timescale of labeling empirically, by FPOP-labeling three oxidation-sensitive proteins and examining their global FPOP product outcomes. The novel test developed to validate conformational invariance during labeling can be applied generally to any footprinting methodology where perturbation to protein structure by the footprint labeling is suspected. The stable modifications can be detected and quantified by the same proteolysis, chromatography, and mass spectrometry techniques employed in proteomics studies; however, proteomics software does not automatically report the residue-resolved full-sequence-coverage footprint information found in proteomics-like FPOP data. Here we report the development of software tools to facilitate a comprehensive and efficient analysis of FPOP data, and demonstrate their use in a study of barstar in its unfolded and native states. We next show that SO₄−· can serve as an alternative non-specific labeling agent that can be generated by the FPOP apparatus on the same fast timescale as ·OH. This demonstrates the tunable nature of FPOP. We have used FPOP to characterize the oligomeric structures of three human apolipoprotein E (ApoE) isoforms and a monomeric mutant in their lipid-free states. Only one isoform of ApoE is strongly associated with Alzheimer's disease; unfortunately, the structural reason for this association is not known, in part because no high resolution structure exists of any isoform. We find that the three common isoforms of ApoE are very similar in their solvent accessible footprint, that their oligomeric interactions involve several regions in the C-terminal domain, and that the N-terminal domain of each resembles the monomeric mutant's N-terminal domain, the truncated form of which has been characterized as a four-helix bundle. Finally, we find by FPOP that ApoE interacts with beta-amyloid peptide 1-42 at a specific site in its N-terminal domain.

Subjects/Keywords: Chemistry, Analytical; Chemistry, Biochemistry; Biology, Bioinformatics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gau, B. C. (2011). The advancement of mass spectrometry-based hydroxyl radical protein footprinting| Application of novel analysis methods to model proteins and apolipoprotein E. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3454303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gau, Brian Craig. “The advancement of mass spectrometry-based hydroxyl radical protein footprinting| Application of novel analysis methods to model proteins and apolipoprotein E.” 2011. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3454303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gau, Brian Craig. “The advancement of mass spectrometry-based hydroxyl radical protein footprinting| Application of novel analysis methods to model proteins and apolipoprotein E.” 2011. Web. 01 Mar 2021.

Vancouver:

Gau BC. The advancement of mass spectrometry-based hydroxyl radical protein footprinting| Application of novel analysis methods to model proteins and apolipoprotein E. [Internet] [Thesis]. Washington University in St. Louis; 2011. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3454303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gau BC. The advancement of mass spectrometry-based hydroxyl radical protein footprinting| Application of novel analysis methods to model proteins and apolipoprotein E. [Thesis]. Washington University in St. Louis; 2011. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3454303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

3. Vitalis, Andreas. Probing the early stages of polyglutamine aggregation with computational methods.

Degree: 2009, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3359878

► Exonic CAG repeat diseases are a class of neurodegenerative age-of-onset diseases caused by an unstable trinucleotide expansion in a coding region of a gene.… (more)

▼ Exonic CAG repeat diseases are a class of neurodegenerative age-of-onset diseases caused by an unstable trinucleotide expansion in a coding region of a gene. The most prominent example is Huntington's disease (HD) whose symptoms are characterized by loss of motor control and cognitive deficits. For all nine of the known CAG repeat diseases, pathology is ascribed to the mutant proteins which carry expanded stretches of glutamine residues (polyglutamine). The length of the polyglutamine segment is inversely correlated with the disease age-of-onset. Protein aggregates are routinely found in postmortem tissue samples of brains of HD patients. These findings suggest a prominent role for polyglutamine-mediated protein aggregation in disease pathogenesis. Subsequent studies characterized the intracellular aggregates as amyloid-like. In amyloids, the polypeptide backbone predominantly adopts conformations in the β-basin of the Ramachandran map, i.e., the aggregates have high net β-content. This has led to the hypothesis that β-rich conformers play a prominent role in mediating the aggregation process; specifically, it has been postulated that a β-rich form of polyglutamine acts as the monomeric nucleus from which fibrillar aggregates grow via a downhill elongation mechanism. This thesis investigates the intrinsic properties of polyglutamine during early stages of aggregation. We employ computer simulations to obtain a qualitative picture of the process at an atomistic level. Our results suggest the following: soluble polyglutamine is intrinsically disordered and forms collapsed globules in aqueous solution. These globules associate readily and randomly to form disordered dimers. We identified no structural requirements for association to occur. The conversion of monomeric polyglutamine to a conformation high in β-content, i.e., to a putative aggregation nucleus, is associated with a high free energy penalty. We detect no coupling between structure and associativity, but find a profound modulation of polyglutamine's intrinsic properties in the presence of wild-type flanking sequences. From our results, we postulate a model where polyglutamine forms large soluble and disordered oligomers which undergo a rate-limiting conformational conversion to a fibrillar precipitate. We conclude that structure-based drug designs may not prove a viable strategy for interfering with the early stages of polyglutamine aggregation and hence with disease pathology.

Subjects/Keywords: Biophysics; Medical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vitalis, A. (2009). Probing the early stages of polyglutamine aggregation with computational methods. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3359878

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vitalis, Andreas. “Probing the early stages of polyglutamine aggregation with computational methods.” 2009. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3359878.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vitalis, Andreas. “Probing the early stages of polyglutamine aggregation with computational methods.” 2009. Web. 01 Mar 2021.

Vancouver:

Vitalis A. Probing the early stages of polyglutamine aggregation with computational methods. [Internet] [Thesis]. Washington University in St. Louis; 2009. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3359878.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vitalis A. Probing the early stages of polyglutamine aggregation with computational methods. [Thesis]. Washington University in St. Louis; 2009. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3359878

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

4. Shockley, Stephany Elaine. Evaluation of the peripheral benzodiazepine receptor as a Positron Emission Tomography imaging target for tumor aggression.

Degree: 2009, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3366047

► The utility of Positron Emission Tomography (PET) in the detection of cancer began with the radiopharmaceutical 2-[¹⁸F]fluoro-2-deoxyglucose (FDG) used for measuring altered cellular metabolism.… (more)

▼ The utility of Positron Emission Tomography (PET) in the detection of cancer began with the radiopharmaceutical 2-[¹⁸F]fluoro-2-deoxyglucose (FDG) used for measuring altered cellular metabolism. Specific radioligands are being developed to allow non-invasive analysis of protein expression to further characterize tumors. One protein that has been identified as a promising target is the Peripheral Benzodiazepine Receptor (PBR). PBR expression is up-regulated in several cancers, and in many there has been a correlation drawn between increased malignancy and protein expression levels. Therefore, developing PET methodologies to apply for PBR imaging could be an important step in understanding individual tumors as we move toward an age of personalized medicine. This dissertation investigates the potential utility of two radioligands specific for PBR, and compares the radioligands to radiopharmaceuticals that map metabolism (FDG) and proliferation (3'-[¹⁸F]fluoro-L-thymidine, FLT). The research has two specific aims: (1) to compare PBR expression with measures of cellular proliferation and aggression; (2) to directly compare radioligand localization in vivo to tumor sites in mouse xenograft model studies. In vitro cell studies indicate a correlation between PBR expression and markers of aggression, but not proliferation. Using PET imaging and biodistribution, breast cancer xenografts with a breadth of PBR expression showed no significant uptake of PBR specific radioligands. However, radiopharmaceuticals targeting proliferation by metabolism and DNA synthesis showed greater differences in uptake between cell lines. The data obtained from these studies demonstrate a limitation to the translation of PBR imaging for personalized medicine, because the ubiquitous expression of the protein throughout the body creates challenges that will be difficult to overcome. Expression of PBR in non-target organs reduces the quantity of radiopharmaceutical that is available for tumor uptake, and the extent of non-tumor uptake of radiopharmaceuticals with affinity for PBR exceeds that of tumors. These results suggest that non-invasive imaging techniques to assay tumor PBR expression in vivo have limited potential for clinical applications.

Subjects/Keywords: Chemistry; Biochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shockley, S. E. (2009). Evaluation of the peripheral benzodiazepine receptor as a Positron Emission Tomography imaging target for tumor aggression. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3366047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shockley, Stephany Elaine. “Evaluation of the peripheral benzodiazepine receptor as a Positron Emission Tomography imaging target for tumor aggression.” 2009. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3366047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shockley, Stephany Elaine. “Evaluation of the peripheral benzodiazepine receptor as a Positron Emission Tomography imaging target for tumor aggression.” 2009. Web. 01 Mar 2021.

Vancouver:

Shockley SE. Evaluation of the peripheral benzodiazepine receptor as a Positron Emission Tomography imaging target for tumor aggression. [Internet] [Thesis]. Washington University in St. Louis; 2009. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3366047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shockley SE. Evaluation of the peripheral benzodiazepine receptor as a Positron Emission Tomography imaging target for tumor aggression. [Thesis]. Washington University in St. Louis; 2009. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3366047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

5. Anderson, Nicholas Robert. Electrocorticographic neural correlates of arm movements and associated goal orientation in humans.

Degree: 2009, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3379094

► This thesis analyzed the cortical representation of arm kinematics, target encoding, and goal encoding using subdural electrocorticographic (ECoG) recordings in humans. Using a joystick-based… (more)

Subjects/Keywords: Biology, Neurobiology; Engineering, Biomedical; Engineering, Electronics and Electrical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Anderson, N. R. (2009). Electrocorticographic neural correlates of arm movements and associated goal orientation in humans. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3379094

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anderson, Nicholas Robert. “Electrocorticographic neural correlates of arm movements and associated goal orientation in humans.” 2009. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3379094.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anderson, Nicholas Robert. “Electrocorticographic neural correlates of arm movements and associated goal orientation in humans.” 2009. Web. 01 Mar 2021.

Vancouver:

Anderson NR. Electrocorticographic neural correlates of arm movements and associated goal orientation in humans. [Internet] [Thesis]. Washington University in St. Louis; 2009. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3379094.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anderson NR. Electrocorticographic neural correlates of arm movements and associated goal orientation in humans. [Thesis]. Washington University in St. Louis; 2009. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3379094

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

6. Glaubius, Robert. Scheduling policy design using stochastic dynamic programming.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3386643

► Scheduling policies for open soft real-time systems must be able to balance the competing concerns of meeting their objectives under exceptional conditions while achieving… (more)

Subjects/Keywords: Computer Science

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Glaubius, R. (2010). Scheduling policy design using stochastic dynamic programming. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3386643

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Glaubius, Robert. “Scheduling policy design using stochastic dynamic programming.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3386643.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Glaubius, Robert. “Scheduling policy design using stochastic dynamic programming.” 2010. Web. 01 Mar 2021.

Vancouver:

Glaubius R. Scheduling policy design using stochastic dynamic programming. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3386643.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Glaubius R. Scheduling policy design using stochastic dynamic programming. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3386643

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

7. Rosen, David Aaron. Conservation of the intracellular bacterial community pathogenic pathway in urinary tract infection.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3397987

► Urinary tract infections (UTIs) affect 13 million women annually in the United States. Uropathogenic Escherichia coli (UPEC) is the predominant etiologic agent of UTI;… (more)

▼ Urinary tract infections (UTIs) affect 13 million women annually in the United States. Uropathogenic Escherichia coli (UPEC) is the predominant etiologic agent of UTI; however, several other uropathogens, including Klebsiella pneumoniae, are also significant causative agents. In a murine cystitis model, UPEC utilize a multistep pathogenic pathway in which they invade and form intracellular bacterial communities (IBCs) within bladder facet cells. Type 1 pili, adhesive fimbriae, are necessary for UPEC binding and invasion of urothelial cells and formation of IBCs. UPEC ultimately disperse from the IBC, many with filamentous morphology, and proceed to infect other host urothelial cells. This work evaluates the conservation of the IBC pathogenic pathway across both host and uropathogen. To determine if the IBC pathway occurs in human UTI, urine samples from women with acute, uncomplicated cystitis and from asymptomatic women were blindly analyzed. We found evidence of IBCs in 18% and filamentous bacteria in 41% of urines from women with UTI. None of the urines from the asymptomatic comparative group or from Gram-positive UTIs showed evidence of IBCs or filaments. These findings suggest that the IBC pathogenic pathway characterized in the mice also occurs in humans. Numerous non-UPEC, Gram-negative uropathogens were found competent for IBC formation in the murine cystitis model. The uropathogenesis of one of these IBC formers, K. pneumoniae, was compared to UPEC. K. pneumoniae was able to colonize the murine bladder and form IBCs, but to a lesser extent than UPEC early in infection. Much of this disparity can be attributed to differences in expression and function of type 1 pili. Specifically, K. pneumoniae encodes an extra fim operon gene, fimK, which inhibits expression of type 1 pili. Additionally, K. pneumoniae has a defect in the mannose-sensitive hemagglutination phenotype of type 1 pili specific to its FimH adhesin domain. These differences in expression and function of K. pneumoniae type 1 pili explain, in part, why K. pneumoniae is a less prevalent etiologic agent of UTI than UPEC. To further analyze host factors involved in UTI pathogenesis of K. pneumoniae and other uropathogens, we developed a streptozocin-induced diabetic model of UTI. Diabetic mice were found to be more susceptible to UTI, especially by non-UPEC uropathogens, compared to healthy mice. This work revealed that the IBC pathogenic pathway occurs in human UTI and is common to several uropathogens, albeit to varying degrees of efficiency. Further insight into this conserved pathway may lead to enhanced UTI treatments and prevention of recurrence.

Subjects/Keywords: Biology, Molecular; Biology, Microbiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rosen, D. A. (2010). Conservation of the intracellular bacterial community pathogenic pathway in urinary tract infection. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3397987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rosen, David Aaron. “Conservation of the intracellular bacterial community pathogenic pathway in urinary tract infection.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3397987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rosen, David Aaron. “Conservation of the intracellular bacterial community pathogenic pathway in urinary tract infection.” 2010. Web. 01 Mar 2021.

Vancouver:

Rosen DA. Conservation of the intracellular bacterial community pathogenic pathway in urinary tract infection. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3397987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rosen DA. Conservation of the intracellular bacterial community pathogenic pathway in urinary tract infection. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3397987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

8. Weissbrod, Lior. The small animals of Maasai settlement| Ethnoarchaeological investigations of the commensalism model.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3398836

► Changes in mobility have long been considered a critical factor affecting social and economic change during transitions from hunting and gathering to food production.… (more)

▼ Changes in mobility have long been considered a critical factor affecting social and economic change during transitions from hunting and gathering to food production. Archaeologists have relied on a wide range of indirect indicators of sedentism and the intensity of site occupation such as site size and structural complexity. One of the key problems has been how to ascertain more precisely how change in mobility combined with other factors of economic and social intensification. More than 40 years ago, Tchernov (Bar-Yosef and Tchernov 1966) first proposed the idea that remains of commensal species that today coexist with humans in settlement environments could be used to detect early sedentism in the archaeological record. Subsequent studies of the earliest occurrence of commensal house mice (Mus musculus domesticus ) in sites of complex Natufian hunter-gatherers of southwest Asia established a link between pronounced levels of commensalism and what is generally believed to have been one of the first sedentary cultures in the world. The commensalism model related increasing populations of commensal species and decreasing biological diversity to changes in the intensity of human site occupation. It was expressly developed to test assumptions about decreasing mobility among Natufian hunter-gatherers and their role in the subsequent domestication of plants and animals and emergence of agricultural villages. The validity of the model was later questioned, however, due to the lack of empirical knowledge on commensalism in a wide range of settlement environments including sedentary and more mobile ones. This research was designed to test Tchernov's commensalism hypothesis through a study of seasonally occupied settlements of Maasai pastoralists in East Africa. Methods from ecology, ethnography, and archaeology were used to document the impact of Maasai settlements on associated communities of small rodents and shrews (micromammals), to measure the intensity of human occupation in settlements, and to relate settlement intensity to micromammalian communities. Taphonomic approaches were also used to evaluate the potential for accumulation and preservation of evidence on commensalism in the substrate of the settlements. The results of the study showed that, in contrast to what we might expect in highly sedentary settings, Maasai settlements increased rather than decreased the biological diversity of local micromammalian communities. Along a gradient of decreasing settlement mobility, but continued seasonal use of settlements, there was no manifest increase in the population of any single species that would amount to pronounced commensalism. This supports the commensalism/sedentism linkage but also suggests more broadly that it should be possible to demarcate distinct contexts of commensalism and related levels of biological diversity in relation to varying intensities of site occupation. These results call for greater investment in systematic fine-recovery and study of variability of…

Subjects/Keywords: African Studies; Anthropology, Archaeology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Weissbrod, L. (2010). The small animals of Maasai settlement| Ethnoarchaeological investigations of the commensalism model. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3398836

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weissbrod, Lior. “The small animals of Maasai settlement| Ethnoarchaeological investigations of the commensalism model.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3398836.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weissbrod, Lior. “The small animals of Maasai settlement| Ethnoarchaeological investigations of the commensalism model.” 2010. Web. 01 Mar 2021.

Vancouver:

Weissbrod L. The small animals of Maasai settlement| Ethnoarchaeological investigations of the commensalism model. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3398836.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weissbrod L. The small animals of Maasai settlement| Ethnoarchaeological investigations of the commensalism model. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3398836

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

9. Kolbe, Diana Lynn. Novel algorithms for structural alignment of non-coding RNAs.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3408095

► Non-coding RNAs are biologically important molecules, with a variety of catalytic and regulatory activities mediated by their secondary and tertiary structures. Base-pairing interactions, particularly… (more)

Subjects/Keywords: Biology; Bioinformatics

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APA (6^th Edition):

Kolbe, D. L. (2010). Novel algorithms for structural alignment of non-coding RNAs. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3408095

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kolbe, Diana Lynn. “Novel algorithms for structural alignment of non-coding RNAs.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3408095.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kolbe, Diana Lynn. “Novel algorithms for structural alignment of non-coding RNAs.” 2010. Web. 01 Mar 2021.

Vancouver:

Kolbe DL. Novel algorithms for structural alignment of non-coding RNAs. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3408095.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kolbe DL. Novel algorithms for structural alignment of non-coding RNAs. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3408095

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

10. McCartney, Stephen Andrew. The role of MDA5 and TLR3 in response to dsRNA and viral infection.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3411811

► The innate immune system consists of a number of genetically encoded receptors that detect the products of viral replication and initiate signaling cascades leading… (more)

▼ The innate immune system consists of a number of genetically encoded receptors that detect the products of viral replication and initiate signaling cascades leading to activation of the antiviral response. During the course of infection, many viruses produce dsRNA that can be recognized by two major arms of the innate immune system: the toll-like receptors (TLR) and the Rig-I-like receptors (RLR). Among the TLRs, TLR3 binds dsRNA within the endosomal compartment and initiates signaling through its downstream adapter TRIF. Melanoma differentiation-induced gene 5 (MDA5) is a member of the RLR family that recognizes dsRNA within the cytosolic compartment and signals through the adaptor IPS-1. Although TLR3 and MDA5 initially employ distinct downstream adaptors, both are known to induce the production of cytokines and cell surface molecules involved in the antiviral response, which raises the question of whether they are redundant or functionally distinct. Using mice that are genetically deficient for MDA5, TLR3, or both MDA5 and TLR3 (double knockout, DKO), we have demonstrated that these receptors have unique functions necessary for controlling viral infection. Using two models of viral infection, murine norovirus (MNV) and encephalomyocarditis virus (EMCV), we demonstrate that both MDA5 and TLR3 limit viral replication. Neither MDA5-/- nor TLR3-/- animals controlled MNV and EMCV infection as well as wild type (WT) controls, but DKO mice were more susceptible to infection than either single knockout. Furthermore, we find that MDA5 and TLR3 play distinct roles in activating the natural killer (NK) cell response to the dsRNA analogue poly I:C (pIC). We demonstrate that the discrete functions of MDA5 and TLR3 are dependent on their expression in different cell types as well as their unique capacities to control production of cytokines. In addition, we show that the individual contribution of each sensor is necessary at distinct phases of the innate immune response, with TLR3 acting initially and MDA5 acting at later time points. These results illustrate how cooperation between the TLR and RLR pathways is necessary for the development of a complete antiviral response.

Subjects/Keywords: Biology, Virology; Health Sciences, Immunology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McCartney, S. A. (2010). The role of MDA5 and TLR3 in response to dsRNA and viral infection. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3411811

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McCartney, Stephen Andrew. “The role of MDA5 and TLR3 in response to dsRNA and viral infection.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3411811.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McCartney, Stephen Andrew. “The role of MDA5 and TLR3 in response to dsRNA and viral infection.” 2010. Web. 01 Mar 2021.

Vancouver:

McCartney SA. The role of MDA5 and TLR3 in response to dsRNA and viral infection. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3411811.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McCartney SA. The role of MDA5 and TLR3 in response to dsRNA and viral infection. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3411811

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

11. Wiseman, Charles Gordon. Abstractions and algorithms for control of extensible and heterogeneous virtualized network infrastructures.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3412319

► Virtualized network infrastructures are currently deployed in both research and commercial contexts. The complexity of the virtualization layer varies greatly in different deployments, ranging… (more)

▼ Virtualized network infrastructures are currently deployed in both research and commercial contexts. The complexity of the virtualization layer varies greatly in different deployments, ranging from cloud computing environments, to carrier Ethernet applications using stacked VLANs, to networking testbeds. In all of these cases, many users are sharing the resources of one provider and each user expects their resources to be isolated from all other users. There are many challenges associated with the control and management of these systems, including resource allocation and sharing, resource isolation, system security, and usability. Among the different types of virtualized infrastructures, network testbeds are of particular interest due to their widespread use in education and in the networking research community. Networking researchers rely extensively on testbeds when evaluating new protocols and ideas. Indeed, a substantial percentage of top research papers include results gathered from testbeds. Network emulation testbeds in particular are often used to conduct innovative research because they allow users to emulate diverse network topologies in a controlled environment. That is, researchers run experiments with a collection of resources that can be reconfigured to represent many different network scenarios. The user typically has control over most of the resources in their experiment which results in a high level of reproducibility. As such, these types of testbeds provide an excellent bridge between simulation and deployment of new ideas. Unfortunately, most testbeds suffer from a general lack of resource extensibility and diversity. This dissertation extends the current state of the art by designing a new, more general testbed infrastructure that expands and enhances the capabilities of modern testbeds. This includes pertinent abstractions, software design, and related algorithms. The design has also been prototyped in the form of the Open Network Laboratory network testbed, which has been successfully used in educational and research pursuits. While the focus is on network testbeds, the results of this research will also be applicable to the broader class of virtualized system infrastructures.

Subjects/Keywords: Computer Science

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APA (6^th Edition):

Wiseman, C. G. (2010). Abstractions and algorithms for control of extensible and heterogeneous virtualized network infrastructures. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3412319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wiseman, Charles Gordon. “Abstractions and algorithms for control of extensible and heterogeneous virtualized network infrastructures.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3412319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wiseman, Charles Gordon. “Abstractions and algorithms for control of extensible and heterogeneous virtualized network infrastructures.” 2010. Web. 01 Mar 2021.

Vancouver:

Wiseman CG. Abstractions and algorithms for control of extensible and heterogeneous virtualized network infrastructures. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3412319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wiseman CG. Abstractions and algorithms for control of extensible and heterogeneous virtualized network infrastructures. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3412319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

12. Scherer, Laura Danielle. Response mapping in evaluative priming.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3422054

► Recently, Scherer and Lambert (2009) proposed a new model of priming, which they called the Response Mapping (RM) Model. That model assumes that under… (more)

Subjects/Keywords: Psychology, Social; Psychology, Cognitive

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APA (6^th Edition):

Scherer, L. D. (2010). Response mapping in evaluative priming. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3422054

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Scherer, Laura Danielle. “Response mapping in evaluative priming.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3422054.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Scherer, Laura Danielle. “Response mapping in evaluative priming.” 2010. Web. 01 Mar 2021.

Vancouver:

Scherer LD. Response mapping in evaluative priming. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3422054.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Scherer LD. Response mapping in evaluative priming. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3422054

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

13. Hicks, Sarah Lynn. Determinants of and variation in large foundations' grantmaking to Native America.

Degree: 2008, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3316627

► As foundation grantmaking has grown over the last decade, scrutiny from potential regulators and the general public has increased. However, little is known about… (more)

▼ As foundation grantmaking has grown over the last decade, scrutiny from potential regulators and the general public has increased. However, little is known about foundations' decision-making processes for grant awards. The unique status of American Indian and Alaska Native tribal governments, their increased capacity over the last 30 years, and the disproportionate socioeconomic disadvantage of Native peoples' position Native communities as potentially significant foundation grantees. Yet research shows that foundation's grantmaking to Native causes generally, and to tribal governments in particular, is disproportionately low (Hicks and Jorgensen, 2004, 2005). This study applies a principal-agent framework to the organizational problem of large foundations' grantmaking to Native causes. Collectively, foundations are challenged to find the best-positioned grantees to fulfill their mission and create significant impact with their investments. They have the choice of agent types, who vary by level of risk, to whom they award grants: intermediary organizations (the safest choice), nonprofit organizations (the referent choice), and tribal governments (the riskiest choice). Foundations use the information that they have available about potential recipients, including information about recipient types, to make grantmaking decisions that minimize the risk that the grantees will act opportunistically or contrary to the foundation's intent. This study applied qualitative and quantitative methods to understand and explain large foundations' grantmaking to Native America. Considerable differences in information sources and grant award decision-making processes were identified. Foundation representatives expressed substantial variation in the factors their foundations considered in Native grant award decisions and the weight they attributed to relative factors. Relationships—the use of colleagues and networks—seemed paramount in assessing potential recipient organization's missions, positioning on an issue, community relationships, and capacity. The multinomial logistic regression model examined tribal governments relative to intermediary organizations (model one) and nonprofit organizations relative to intermediary organizations (model two). While the intercept for model one was significant (p < .05), the intercept for model two was not. Foundation type, total foundation grantmaking, and peer tribal government grantmaking contribute to predicting large foundations' choice of intermediary organizations relative to tribal governments. The geographic scope of foundations' grantmaking is a meaningful constraint on choice of recipient type.

Subjects/Keywords: Social Work; Native American Studies

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hicks, S. L. (2008). Determinants of and variation in large foundations' grantmaking to Native America. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3316627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hicks, Sarah Lynn. “Determinants of and variation in large foundations' grantmaking to Native America.” 2008. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3316627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hicks, Sarah Lynn. “Determinants of and variation in large foundations' grantmaking to Native America.” 2008. Web. 01 Mar 2021.

Vancouver:

Hicks SL. Determinants of and variation in large foundations' grantmaking to Native America. [Internet] [Thesis]. Washington University in St. Louis; 2008. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3316627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hicks SL. Determinants of and variation in large foundations' grantmaking to Native America. [Thesis]. Washington University in St. Louis; 2008. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3316627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

14. Nair, Ciju T. R. Essays on online browsing and purchase.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3427319

► Essay One: Modeling Online Browsing and Purchase of Airline Tickets. Online purchases are increasingly becoming a significant portion of total purchases in most… (more)

▼ Essay One: Modeling Online Browsing and Purchase of Airline Tickets. Online purchases are increasingly becoming a significant portion of total purchases in most product categories. While prior research in marketing has looked at information search and purchase decisions separately, we use a joint framework to study consumers' online browsing and purchase of airline tickets in a unique dataset of household-level dynamic click stream panel data. We use a three-stage model to study (i) the choice of the first website visited, (ii) the duration of browsing on travel websites before making a purchase (iii) the choice of the website where consumers will make the purchase, and how a later stage choice is affected by decisions in previous stages. We simultaneously estimate these three models which constitute a non-linear discrete-continuous equation system using a simulation-based econometric technique. We find significant effects of expected level of expenditure, prior browsing experience, prior purchase experience in determining consumer browsing and purchase behavior. We are able to quantify the differences in attractiveness of a website in getting consumers to first visit them and compare it with the conversion effectiveness of a website in terms of getting consumers who visit to make purchases. A significant impact of choice of the first site visited and browsing duration on choice of the purchase site indicates the importance of modeling these decisions simultaneously. Our results can help managers identify the major determinants of consumer browsing and online purchase behavior, some of which cannot be observed in a brick-and-mortar environment. Essay Two: Modeling Online Multi-category Purchase in Travel. In this paper we investigate online purchase behavior at the basket level and model the multi-category purchases in the travel product category. While prior research in marketing has looked at browsing or individual category purchase decisions, we study consumers' online purchase of airline, car rental and hotel purchases together using a unique dataset of household-level dynamic click stream panel data. We use a two-stage model to study (i) the propensity of consumers to purchase a combination of products as a basket and (ii) the choice of the website where consumers will make those purchases. We then estimate the propensity of consumers to purchase a particular combination of products in their basket from different websites. This behavior constitutes a high dimensional system of multinomial equations which are then solved using a simulation-based econometric technique. We find significant effects of site preference, loyalty, prior browsing and demographic variables in determining consumer multi-category purchase behavior. Our results can help managers identify the major determinants of multi-category purchase as well as provide insights into cross promoting as well as upselling other products to consumers who visit their website. Key Words: airline, car rental, hotel,…

Subjects/Keywords: Business Administration, Marketing; Statistics; Economics, General; Web Studies

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nair, C. T. R. (2010). Essays on online browsing and purchase. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3427319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nair, Ciju T R. “Essays on online browsing and purchase.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3427319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nair, Ciju T R. “Essays on online browsing and purchase.” 2010. Web. 01 Mar 2021.

Vancouver:

Nair CTR. Essays on online browsing and purchase. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3427319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nair CTR. Essays on online browsing and purchase. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3427319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

15. McClendon, Jennifer Rachel. Who uses community-based youth shelters? An inter-group and intra-group analysis.

Degree: 2009, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3369214

► Community-based youth shelters are the primary method of intervention designed to meet the complex needs of at-risk youth who leave home before they have… (more)

▼ Community-based youth shelters are the primary method of intervention designed to meet the complex needs of at-risk youth who leave home before they have developed the skills to live independently. This research examines shelter users' patterns of cross-sector service use to better understand the needs and resources of shelter residents. The aims of this study are (1) to perform an inter-group analysis, comparing sheltered youth with status offense runaways and foster care runaways, and (2) to explore the population of emergency shelter residents using an intra-group analysis, determining whether distinct profiles of sheltered youth exist, based on individual characteristics and service use patterns over time. The study samples were drawn from a larger longitudinal study of services and outcomes. The samples included subjects born between 1981 and 1992 who were reported for child maltreatment and/or lived in families receiving Aid to Families with Dependent Children during childhood. For the first Aim, the sample included subjects identified as runaway by the court system (status offense runaways), foster care runaways, and sheltered youth. The sample for the second aim included only sheltered youth. Bivariate analyses found differences between runaway groups in terms of poverty, maltreatment history, school-identified disability, report of neglect, receipt of family services, delinquent offenses, truancy, ethnicity, and parent mental health or substance abuse treatment. Controlling for covariates in the multinomial logistic regression, only age discriminated between all three groups. Just 20% of the sheltered youth ran away from their previous residence or spent time living on the street. Latent class analysis suggests sheltered youth fall into four clearly distinct categories, clearly defined by connection to school and family. These include: (1) a "parent time-out" group (attending school and living with family), (2) a school/behavior problem group (not attending school and living with family), (3) youth in DFS custody placed at the shelter (disconnected from family but attending school), and (4) multi-problem youth (disconnected from both school and family).

Subjects/Keywords: Social Work; Sociology, Public and Social Welfare

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McClendon, J. R. (2009). Who uses community-based youth shelters? An inter-group and intra-group analysis. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3369214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McClendon, Jennifer Rachel. “Who uses community-based youth shelters? An inter-group and intra-group analysis.” 2009. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3369214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McClendon, Jennifer Rachel. “Who uses community-based youth shelters? An inter-group and intra-group analysis.” 2009. Web. 01 Mar 2021.

Vancouver:

McClendon JR. Who uses community-based youth shelters? An inter-group and intra-group analysis. [Internet] [Thesis]. Washington University in St. Louis; 2009. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3369214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McClendon JR. Who uses community-based youth shelters? An inter-group and intra-group analysis. [Thesis]. Washington University in St. Louis; 2009. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3369214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

16. Holt, Daniel D. Temporal discounting| A comparison of adjusting-amount and adjusting-delay procedures.

Degree: 2009, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3371614

► Several experimental procedures (e.g., adjusting amount, adjusting delay) have been used to study the effect that changes in amount of and delay to a… (more)

Subjects/Keywords: Psychology; Experimental

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APA (6^th Edition):

Holt, D. D. (2009). Temporal discounting| A comparison of adjusting-amount and adjusting-delay procedures. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3371614

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Holt, Daniel D. “Temporal discounting| A comparison of adjusting-amount and adjusting-delay procedures.” 2009. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3371614.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Holt, Daniel D. “Temporal discounting| A comparison of adjusting-amount and adjusting-delay procedures.” 2009. Web. 01 Mar 2021.

Vancouver:

Holt DD. Temporal discounting| A comparison of adjusting-amount and adjusting-delay procedures. [Internet] [Thesis]. Washington University in St. Louis; 2009. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3371614.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Holt DD. Temporal discounting| A comparison of adjusting-amount and adjusting-delay procedures. [Thesis]. Washington University in St. Louis; 2009. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3371614

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

17. Wiseman, Sandra Margot. Spectral and stratigraphic mapping of hydrated sulfate and phyllosilicate-bearing deposits| Implications for the aqueous history of Sinus Meridiani, Mars.

Degree: 2009, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3371615

► Data acquired by the Mars Reconnaissance Orbiter (MRO) are used in conjunction with additional data sets to perform detailed stratigraphic and spectral analyses with… (more)

▼ Data acquired by the Mars Reconnaissance Orbiter (MRO) are used in conjunction with additional data sets to perform detailed stratigraphic and spectral analyses with the goal of identifying and mapping the mineralogy and stratigraphy of sedimentary deposits to infer the aqueous history of the Sinus Meridiani region on Mars. Datasets utilized include MRO Compact Reconnaissance Imaging Spectrometer for Mars (CRISM), MRO Context Imager, MRO High Resolution Imaging Science Experiment, Mars Express (MEX) Observatoire pour la Minéralogie, l'Eau, les Glaces et l'Activite, MEX High Resolution Stereo Camera, Mars Odyssey (ODY) Thermal Emission Imaging System, ODY Mars Orbital Camera, and ODY Mars Orbiter Laser Altimeter data. Spectral analyses focus on detection, identification, and mapping of hydrated and/or hydroxylated alteration minerals in the near infrared region between ∼1.0 and 2.5 μm. An extensive analysis is presented on methods for the retrieval of atmospherically corrected CRISM surface Lambert Albedo spectra using Discrete Ordinate Radiative Transfer modeling. Sedimentary deposits indicative of a complex aqueous history occur in Sinus Meridiani. Fe/Mg phyllosilicate minerals, including Fe/Mg smectites, are detected in ancient Noachian cratered terrains. Fe/Mg smectites also occur in association with layered sedimentary deposits that unconformably overlie the Noachian cratered terrain. Both of these units predate the formation of the sulfate and hematite-bearing unit on which the Mars Exploration Rover Opportunity landed. At least one episode of intense erosion acted on the sedimentary deposits. A thick sequence of layered hydrated sulfate deposits that are texturally and spectrally distinct from the sulfate rich bedrock explored by the Opportunity Rover occurs in northern Sinus Meridiani. Detailed stratigraphic analyses indicate that these deposits are not readily explained by a simple layered stratigraphy and an unconformable facies change is inferred to have occurred. The presence of Fe/Mg smectite-bearing deposits indicates that the low pH conditions experienced by younger hematite-bearing materials are not representative of the aqueous geochemical environment that prevailed during the formation of earlier materials. The deposits in Sinus Meridiani record the transition from an open hydrologic system with near neutral pH conditions to a more arid acid-sulfate dominated ground water system.

Subjects/Keywords: Geology; Physics, Astronomy and Astrophysics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wiseman, S. M. (2009). Spectral and stratigraphic mapping of hydrated sulfate and phyllosilicate-bearing deposits| Implications for the aqueous history of Sinus Meridiani, Mars. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3371615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wiseman, Sandra Margot. “Spectral and stratigraphic mapping of hydrated sulfate and phyllosilicate-bearing deposits| Implications for the aqueous history of Sinus Meridiani, Mars.” 2009. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3371615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wiseman, Sandra Margot. “Spectral and stratigraphic mapping of hydrated sulfate and phyllosilicate-bearing deposits| Implications for the aqueous history of Sinus Meridiani, Mars.” 2009. Web. 01 Mar 2021.

Vancouver:

Wiseman SM. Spectral and stratigraphic mapping of hydrated sulfate and phyllosilicate-bearing deposits| Implications for the aqueous history of Sinus Meridiani, Mars. [Internet] [Thesis]. Washington University in St. Louis; 2009. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3371615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wiseman SM. Spectral and stratigraphic mapping of hydrated sulfate and phyllosilicate-bearing deposits| Implications for the aqueous history of Sinus Meridiani, Mars. [Thesis]. Washington University in St. Louis; 2009. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3371615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

18. Nawrocki, Eric Paul. Structural RNA homology search and alignment using covariance models.

Degree: 2009, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3372748

► Functional RNA elements do not encode proteins, but rather function directly as RNAs. Many different types of RNAs play important roles in a wide… (more)

▼ Functional RNA elements do not encode proteins, but rather function directly as RNAs. Many different types of RNAs play important roles in a wide range of cellular processes, including protein synthesis, gene regulation, protein transport, splicing, and more. Because important sequence and structural features tend to be evolutionarily conserved, one way to learn about functional RNAs is through comparative sequence analysis - by collecting and aligning examples of homologous RNAs and comparing them. Covariance models (CMs) are powerful computational tools for homology search and alignment that score both the conserved sequence and secondary structure of an RNA family. However, due to the high computational complexity of their search and alignment algorithms, searches against large databases and alignment of large RNAs like small subunit ribosomal RNA (SSU rRNA) are prohibitively slow. Large-scale alignment of SSU rRNA is of particular utility for environmental survey studies of microbial diversity which often use the rRNA as a phylogenetic marker of microorganisms. In this work, we improve CM methods by making them faster and more sensitive to remote homology. To accelerate searches, we introduce a query-dependent banding (QDB) technique that makes scoring sequences more efficient by restricting the possible lengths of structural elements based on their probability given the model. We combine QDB with a complementary filtering method that quickly prunes away database subsequences deemed unlikely to receive high CM scores based on sequence conservation alone. To increase search sensitivity, we apply two model parameterization strategies from protein homology search tools to CMs. As judged by our benchmark, these combined approaches yield about a 250-fold speedup and significant increase in search sensitivity compared with previous implementations. To accelerate alignment, we apply a method that uses a fast sequence-based alignment of a target sequence to determine constraints for the more expensive CM sequence- and structure-based alignment. This technique reduces the time required to align one SSU rRNA sequence from about 15 minutes to 1 second with a negligible effect on alignment accuracy. Collectively, these improvements make CMs more powerful and practical tools for RNA homology search and alignment.

Subjects/Keywords: Biology, Molecular; Biology, Bioinformatics; Computer Science

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APA (6^th Edition):

Nawrocki, E. P. (2009). Structural RNA homology search and alignment using covariance models. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3372748

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nawrocki, Eric Paul. “Structural RNA homology search and alignment using covariance models.” 2009. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3372748.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nawrocki, Eric Paul. “Structural RNA homology search and alignment using covariance models.” 2009. Web. 01 Mar 2021.

Vancouver:

Nawrocki EP. Structural RNA homology search and alignment using covariance models. [Internet] [Thesis]. Washington University in St. Louis; 2009. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3372748.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nawrocki EP. Structural RNA homology search and alignment using covariance models. [Thesis]. Washington University in St. Louis; 2009. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3372748

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

19. Arbor, Sage Child. Mimicking reverse turns with cyclic tetrapeptides.

Degree: 2008, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3332059

► Chemical mimics of the reverse turn structures in proteins have proven useful as therapeutics. This thesis describes the investigation of cyclic tetrapeptides (CTPs) which… (more)

Subjects/Keywords: Biology, Molecular; Chemistry, Biochemistry; Chemistry, Pharmaceutical

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APA (6^th Edition):

Arbor, S. C. (2008). Mimicking reverse turns with cyclic tetrapeptides. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3332059

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arbor, Sage Child. “Mimicking reverse turns with cyclic tetrapeptides.” 2008. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3332059.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arbor, Sage Child. “Mimicking reverse turns with cyclic tetrapeptides.” 2008. Web. 01 Mar 2021.

Vancouver:

Arbor SC. Mimicking reverse turns with cyclic tetrapeptides. [Internet] [Thesis]. Washington University in St. Louis; 2008. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3332059.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arbor SC. Mimicking reverse turns with cyclic tetrapeptides. [Thesis]. Washington University in St. Louis; 2008. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3332059

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

20. Buerge, Brandon T. The vortex flap.

Degree: 2008, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3332070

► The Vortex Flap is a new type of mechanically driven high-lift device consisting of a rotating cylinder placed underneath and near the trailing edge… (more)

Subjects/Keywords: Engineering, Aerospace; Engineering, Mechanical

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APA (6^th Edition):

Buerge, B. T. (2008). The vortex flap. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3332070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Buerge, Brandon T. “The vortex flap.” 2008. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3332070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Buerge, Brandon T. “The vortex flap.” 2008. Web. 01 Mar 2021.

Vancouver:

Buerge BT. The vortex flap. [Internet] [Thesis]. Washington University in St. Louis; 2008. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3332070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Buerge BT. The vortex flap. [Thesis]. Washington University in St. Louis; 2008. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3332070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

21. Watkins, Paul V. Feature topography and sound intensity level encoding in primary auditory cortex.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3387456

► The primary auditory cortex (A1) in mammals is one of the first areas in the neocortex that receives auditory related spiking activity from the… (more)

▼ The primary auditory cortex (A1) in mammals is one of the first areas in the neocortex that receives auditory related spiking activity from the thalamus. Because the neocortex is implicated in regulating high-level brain phenomena, such as attention and perception, it is therefore important in regards to these high-level behaviors to understand how sounds are represented and transformed by neuronal circuits in this area. The topographic organization of neuronal responses to auditory features in A1 provides evidence for potential mechanisms and functional roles of this neural circuitry. This dissertation presents results from models of topographic organization supporting the notion that if the topographic organization of frequency responses, termed tonotopy or cochleotopy, is aligned along the longest anatomical line segment in A1, as supported by some physiological studies, then it is unlikely that any other topography is mapped monotonically along the orthogonal axis. Thresholds of neuronal responses to sound intensity level represent a particular feature that may have a local, highly periodic topography and that is vital to the sensitivity of the auditory system. The neuronal representation of sound level in A1, particularly as it relates to encoding accuracy, contains a distribution of neurons with varying amounts of inhibition at high sound levels. Neurons with large amounts of this high-level inhibition are described as nonmonotonic or level-tuned. This dissertation presents evidence from single neuron recordings in A1 that neurons exhibiting greater high-level inhibition also exhibit lower neuronal thresholds and that lower thresholds in these nonmonotonic neurons are preserved even when much of the neuronal population is adapted for accurately encoding more intense sounds. Evidence presented in this dissertation also suggests that nonmonotonic neurons have transient responses to time-varying (dynamic) level stimuli that adapt more quickly in response to low-level sounds than those of monotonic neurons. Together these results imply that under static, steady-state-dynamic and transient-dynamic sound level conditions, nonmonotonic neurons are specialized encoders of less intense sounds that allow the auditory system to maintain sensitivity under a variety of environmental conditions.

Subjects/Keywords: Biology, Neuroscience; Engineering, Biomedical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Watkins, P. V. (2010). Feature topography and sound intensity level encoding in primary auditory cortex. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3387456

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Watkins, Paul V. “Feature topography and sound intensity level encoding in primary auditory cortex.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3387456.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Watkins, Paul V. “Feature topography and sound intensity level encoding in primary auditory cortex.” 2010. Web. 01 Mar 2021.

Vancouver:

Watkins PV. Feature topography and sound intensity level encoding in primary auditory cortex. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3387456.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Watkins PV. Feature topography and sound intensity level encoding in primary auditory cortex. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3387456

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

22. Bradley, Michael John. Computational and experimental investigation of allosteric communication in the transcriptional regulator NikR.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3387550

► The Ni²⁺ and DNA binding protein NikR is involved in nickel regulation in Escherichia coli through transcriptional repression of the NikABCDE nickel permease. NikR… (more)

▼ The Ni²⁺ and DNA binding protein NikR is involved in nickel regulation in Escherichia coli through transcriptional repression of the NikABCDE nickel permease. NikR is a homotetramer and each chain contains both a DNA binding ribbon-helix-helix (RHH) domain and a Ni²⁺ binding regulatory ACT (aspartokinase, chorismate mutase, TyrA) fold. Work herein combines computational modeling of NikR structure with experimental studies aimed at understanding allosteric communication between the ACT and RHH domains. Hydrogen/deuterium exchange mass spectrometry shows a Ni²⁺ specific NikR conformational change relative to bound Cu²⁺, Co²⁺, and Zn²⁺. Concurrent coordination geometry and in vivo repressor function studies show that NikR activation is specific to binding Ni²⁺ in square-planar geometry. These results suggest that regions of the NikR structure distal to the Ni²⁺ binding sites are involved in allosteric communication. To help determine important residue interactions within and between the RHH and ACT domains that are involved in allostery, an equilibrium molecular dynamics (MD) simulation is utilized to explore the conformational dynamics of the NikR tetramer. This study includes advances in methods development focused on identifying signatures of allosteric communication in MD simulations. Using two different correlation measures based on fluctuations in atomic position and non-covalent bonding, we identify a potential allosteric communication pathway between the Ni²⁺ and DNA binding sites. We also apply a graph theoretic approach to map the most probable networks of non-covalent contacts connecting the two functionally important binding sites. Several of the residues identified by our analyses have been shown experimentally to be important for NikR function. An additional subset of the selected residues structurally connects experimentally important residues and may help coordinate allosteric communication between the ACT and RHH domains. Based on these analyses and additional structural interpretations, site-directed mutagenesis of E. coli NikR and subsequent characterization of changes in Ni²⁺ binding and in vivo repressor function of mutants aid our understanding of the role of these residues in allosteric regulation. The combination of computational and experimental methods that are developed or adapted in this study provides a framework for further characterization of NikR, other ACT domain containing proteins, and other allosteric proteins.

Subjects/Keywords: Biology, Molecular; Chemistry, Biochemistry; Biophysics, General

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bradley, M. J. (2010). Computational and experimental investigation of allosteric communication in the transcriptional regulator NikR. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3387550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bradley, Michael John. “Computational and experimental investigation of allosteric communication in the transcriptional regulator NikR.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3387550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bradley, Michael John. “Computational and experimental investigation of allosteric communication in the transcriptional regulator NikR.” 2010. Web. 01 Mar 2021.

Vancouver:

Bradley MJ. Computational and experimental investigation of allosteric communication in the transcriptional regulator NikR. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3387550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bradley MJ. Computational and experimental investigation of allosteric communication in the transcriptional regulator NikR. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3387550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

23. Wyczalkowski, Matthew A. Advances in computational solvation thermodynamics.

Degree: 2010, Washington University in St. Louis

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=3387681

► The aim of this thesis is to develop improved methods for calculating the free energy, entropy and enthalpy of solvation from molecular simulations. Solvation… (more)

Subjects/Keywords: Physics, Condensed Matter; Biophysics, General

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APA (6^th Edition):

Wyczalkowski, M. A. (2010). Advances in computational solvation thermodynamics. (Thesis). Washington University in St. Louis. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=3387681

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wyczalkowski, Matthew A. “Advances in computational solvation thermodynamics.” 2010. Thesis, Washington University in St. Louis. Accessed March 01, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=3387681.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wyczalkowski, Matthew A. “Advances in computational solvation thermodynamics.” 2010. Web. 01 Mar 2021.

Vancouver:

Wyczalkowski MA. Advances in computational solvation thermodynamics. [Internet] [Thesis]. Washington University in St. Louis; 2010. [cited 2021 Mar 01]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3387681.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wyczalkowski MA. Advances in computational solvation thermodynamics. [Thesis]. Washington University in St. Louis; 2010. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=3387681

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

24. Kivitz, Griffin. Design and Validation of a Dynamic Pressure-Based Loading Device and 3D Strain Tracking Protocol for Ventral Hernia Modeling.

Degree: MS, Mechanical Engineering & Materials Science, 2020, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/508

► It is estimated that 350,000-500,000 ventral hernia repair surgeries are performed each year in the United States. While the long-term recurrence rate of ventral hernia… (more)

▼ It is estimated that 350,000-500,000 ventral hernia repair surgeries are performed each year in the United States. While the long-term recurrence rate of ventral hernia repairs is not yet known, when tissues are exposed to the trauma of surgery, there is always the chance of recurrence. Commonly used ex vivo testing methods for determining the mechanical properties of the abdominal wall and biomaterials for hernia repair consist primarily of uniaxial and biaxial testing, which are not physiologically relevant loading environments. The need for a testing device that can exert physiologically relevant loads ex vivo to an abdominal wall is crucial for the development of more effective repair strategies and products. After abdominal hernia repairs, coughing poses a major threat to the structural integrity of the repair site. During a cough, the intra-abdominal pressure (IAP) can rise as high as 2.5 psi, compared to the normal IAP of approximately 0.1-0.2 psi. The goal of this project was to design a testing device that can apply and measure a representative coughing force applied to an ex vivo porcine abdominal wall, and develop a strain tracking protocol to track three-dimensional abdominal deformation throughout the duration of the cough. The constructed device was successful in applying a physiologically relevant force to a porcine abdominal wall, and subsequently decreasing the force back to a normal IAP in less than 2 seconds. The maximum force of the cough can be easily controlled using the Arduino controller, which makes the device robust enough to explore the effects of a range of pressures. By recording a video of the cough using a 3D camera, we were able to successfully track the deformation of the tissue in three-dimensions with an acceptable level of accuracy. The design and validation of this testing method will pave the way for a variety of experiments that will provide greater insight into the mechanical behavior of the abdominal wall and the effectiveness of various repair strategies and products on restoring native tissue function. Advisors/Committee Members: Dr. Spencer Lake Dr. Jeffrey Blatnik, MD Dr. Jessica Wagenseil, Dr. Spencer Lake Dr. Jeffrey Blatnik, MD Dr. Jessica Wagenseil.

Subjects/Keywords: Hernia; Cough; 3D Tracking; Abdomen; Biomedical Engineering and Bioengineering; Engineering; Mechanical Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kivitz, G. (2020). Design and Validation of a Dynamic Pressure-Based Loading Device and 3D Strain Tracking Protocol for Ventral Hernia Modeling. (Thesis). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kivitz, Griffin. “Design and Validation of a Dynamic Pressure-Based Loading Device and 3D Strain Tracking Protocol for Ventral Hernia Modeling.” 2020. Thesis, Washington University in St. Louis. Accessed March 01, 2021. https://openscholarship.wustl.edu/eng_etds/508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kivitz, Griffin. “Design and Validation of a Dynamic Pressure-Based Loading Device and 3D Strain Tracking Protocol for Ventral Hernia Modeling.” 2020. Web. 01 Mar 2021.

Vancouver:

Kivitz G. Design and Validation of a Dynamic Pressure-Based Loading Device and 3D Strain Tracking Protocol for Ventral Hernia Modeling. [Internet] [Thesis]. Washington University in St. Louis; 2020. [cited 2021 Mar 01]. Available from: https://openscholarship.wustl.edu/eng_etds/508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kivitz G. Design and Validation of a Dynamic Pressure-Based Loading Device and 3D Strain Tracking Protocol for Ventral Hernia Modeling. [Thesis]. Washington University in St. Louis; 2020. Available from: https://openscholarship.wustl.edu/eng_etds/508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

25. Wang, Sijia. Predicate Informed Syntax-Guidance for Semantic Role Labeling.

Degree: MS, Computer Science & Engineering, 2020, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/519

► In this thesis, we consider neural network approaches to the semantic role labeling task in seman-tic parsing. Recent state-of-the-art results for semantic role labeling are… (more)

Subjects/Keywords: Engineering

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APA (6^th Edition):

Wang, S. (2020). Predicate Informed Syntax-Guidance for Semantic Role Labeling. (Thesis). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Sijia. “Predicate Informed Syntax-Guidance for Semantic Role Labeling.” 2020. Thesis, Washington University in St. Louis. Accessed March 01, 2021. https://openscholarship.wustl.edu/eng_etds/519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Sijia. “Predicate Informed Syntax-Guidance for Semantic Role Labeling.” 2020. Web. 01 Mar 2021.

Vancouver:

Wang S. Predicate Informed Syntax-Guidance for Semantic Role Labeling. [Internet] [Thesis]. Washington University in St. Louis; 2020. [cited 2021 Mar 01]. Available from: https://openscholarship.wustl.edu/eng_etds/519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang S. Predicate Informed Syntax-Guidance for Semantic Role Labeling. [Thesis]. Washington University in St. Louis; 2020. Available from: https://openscholarship.wustl.edu/eng_etds/519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

26. Schovanec, Cory. CFD modeling of Vertical Axis Wind Turbine Arrays using Actuator Cylinder Theory.

Degree: MS, Mechanical Engineering & Materials Science, 2020, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/532

► The goal of this thesis is to analyze the flow field and power generation from a vertical axis wind turbine (VAWT) by extending the Actuator… (more)

Subjects/Keywords: Aerodynamics and Fluid Mechanics; Engineering

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APA (6^th Edition):

Schovanec, C. (2020). CFD modeling of Vertical Axis Wind Turbine Arrays using Actuator Cylinder Theory. (Thesis). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/532

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schovanec, Cory. “CFD modeling of Vertical Axis Wind Turbine Arrays using Actuator Cylinder Theory.” 2020. Thesis, Washington University in St. Louis. Accessed March 01, 2021. https://openscholarship.wustl.edu/eng_etds/532.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schovanec, Cory. “CFD modeling of Vertical Axis Wind Turbine Arrays using Actuator Cylinder Theory.” 2020. Web. 01 Mar 2021.

Vancouver:

Schovanec C. CFD modeling of Vertical Axis Wind Turbine Arrays using Actuator Cylinder Theory. [Internet] [Thesis]. Washington University in St. Louis; 2020. [cited 2021 Mar 01]. Available from: https://openscholarship.wustl.edu/eng_etds/532.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schovanec C. CFD modeling of Vertical Axis Wind Turbine Arrays using Actuator Cylinder Theory. [Thesis]. Washington University in St. Louis; 2020. Available from: https://openscholarship.wustl.edu/eng_etds/532

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

27. Kim, Seunghwan. Predicting Disease Progression Using Deep Recurrent Neural Networks and Longitudinal Electronic Health Record Data.

Degree: MS, Computer Science & Engineering, 2020, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/521

► Electronic Health Records (EHR) are widely adopted and used throughout healthcare systems and are able to collect and store longitudinal information data that can be… (more)

▼ Electronic Health Records (EHR) are widely adopted and used throughout healthcare systems and are able to collect and store longitudinal information data that can be used to describe patient phenotypes. From the underlying data structures used in the EHR, discrete data can be extracted and analyzed to improve patient care and outcomes via tasks such as risk stratification and prospective disease management. Temporality in EHR is innately present given the nature of these data, however, and traditional classification models are limited in this context by the cross- sectional nature of training and prediction processes. Finding temporal patterns in EHR is especially important as it encodes temporal concepts such as event trends, episodes, cycles, and abnormalities. Previously, there have been attempts to utilize temporal neural network models to predict clinical intervention time and mortality in the intensive care unit (ICU) and recurrent neural network (RNN) models to predict multiple types of medical conditions as well as medication use. However, such work has been limited in scope and generalizability beyond the immediate use cases that have been focused upon. In order to extend the relevant knowledge- base, this study demonstrates a predictive modeling pipeline that can extract and integrate clinical information from the EHR, construct a feature set, and apply a deep recurrent neural network (DRNN) to model complex time stamped longitudinal data for monitoring and managing the progression of a disease condition. It utilizes longitudinal data of pediatric patient cohort diagnosed with Neurofibromatosis Type 1 (NF1), which is one of the most common neurogenetic disorders and occurs in 1 of every 3,000 births, without predilection for race, sex, or ethnicity. The prediction pipeline is differentiable from other efforts to-date that have sought to model NF1 progression in that it involves the analysis of multi-dimensional phenotypes wherein the DRNN is able to model complex non-linear relationships between event points in the longitudinal data both temporally and . Such an approach is critical when seeking to transition from traditional evidence-based care models to precision medicine paradigms. Furthermore, our predictive modeling pipeline can be generalized and applied to manage the progression and stratify the risks in other similar complex diseases, as it can predict multiple set of sub-phenotypical features from training on longitudinal event sequences. Advisors/Committee Members: Philip R.O. Payne, Chenyang Lu Yixin chen.

Subjects/Keywords: electronic health record; neurofibromatosis type 1; recurrent neural network; long short-term memory; gated recurrent unit; Artificial Intelligence and Robotics; Biostatistics; Engineering; Longitudinal Data Analysis and Time Series; Other Medicine and Health Sciences; Statistical Models

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, S. (2020). Predicting Disease Progression Using Deep Recurrent Neural Networks and Longitudinal Electronic Health Record Data. (Thesis). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/521

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, Seunghwan. “Predicting Disease Progression Using Deep Recurrent Neural Networks and Longitudinal Electronic Health Record Data.” 2020. Thesis, Washington University in St. Louis. Accessed March 01, 2021. https://openscholarship.wustl.edu/eng_etds/521.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, Seunghwan. “Predicting Disease Progression Using Deep Recurrent Neural Networks and Longitudinal Electronic Health Record Data.” 2020. Web. 01 Mar 2021.

Vancouver:

Kim S. Predicting Disease Progression Using Deep Recurrent Neural Networks and Longitudinal Electronic Health Record Data. [Internet] [Thesis]. Washington University in St. Louis; 2020. [cited 2021 Mar 01]. Available from: https://openscholarship.wustl.edu/eng_etds/521.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim S. Predicting Disease Progression Using Deep Recurrent Neural Networks and Longitudinal Electronic Health Record Data. [Thesis]. Washington University in St. Louis; 2020. Available from: https://openscholarship.wustl.edu/eng_etds/521

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

28. Walker, Michael Ray. Joint Estimation of Attenuation and Scatter for Tomographic Imaging with the Broken Ray Transform.

Degree: PhD, Electrical & Systems Engineering, 2020, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/554

► The single-scatter approximation is fundamental for many tomographic imaging problems. This class broadly includes x-ray scattering imaging and optical scatter imaging for certain media. In… (more)

▼ The single-scatter approximation is fundamental for many tomographic imaging problems. This class broadly includes x-ray scattering imaging and optical scatter imaging for certain media. In all cases, noisy measurements are affected by both local events and nonlocal attenuation. Related applications typically focus on reconstructing one of two images: scatter density or total attenuation. However, both images are media specific. Both images are useful for object identification. Knowledge of one image aides estimation of the other, especially when estimating images from noisy data.Joint image recovery has been demonstrated analytically in the context of the broken ray transform (BRT) for attenuation and scatter-density images. The BRT summarizes the nonlocal affects of attenuation in single-scatter measurement geometries. We find BRT analysis particularly interesting as joint image recovery has been demonstrated analytically using only two scatter angles. Limiting observations to two scatter angles is significant because it supports joint reconstruction in two dimensions for anisotropic scatter modalities (e.g. Bragg, Compton). However, all analytic inversion strategies share two fundamental assumptions limiting their utility: nonzero scatter everywhere, and a deterministic data model.There are two themes to our work. First, we consider the BRT in a purely deterministic setting. We are the first to recognize the BRT as a linear shift-invariant operator. This linear-systems perspective motivates frequency-domain analysis both of the data and operator. Frequency-domain representations provide new insights on the operator and a common framework for contrasting recent inversion formulas. New algorithms are presented for regularized inversion of the BRT in addition to fast forward and adjoint operators. Second, we incorporate the BRT in a stochastic data model. Approximating the detectors as photon counting processes, we model the data as Poisson distributed. Our iterative algorithm, alternating scatter and attenuation image updates, guarantees monotonic reduction of the regularized log-likelihood function of the data. We are the first to consider joint image estimation from noisy data. Our results demonstrate a significant improvement over analytic methods for data sets with missing data (regions with zero scatter). In addition to joint image estimation, our approach can be specialized for single image estimation. With known attenuation, we can improve the quality of scatter image estimates. Similarly, with known scatter, we can improve the quality of attenuation image estimates.Through analysis and simulations, we highlight challenges for attenuation image estimation from BRT data, and ambiguity in the joint image recovery problem. Performance will vary with scaling of the problem. Total attenuation, detected counts, and scatter angle all affect the quality of image estimates. We are the first to incorporate both scatter density and attenuation in noisy data models. Our results demonstrate the benefits of accounting for… Advisors/Committee Members: Joseph A. O'Sullivan, R. Martin Arthur, Ulugbek S. Kamilov, David G. Politte, Yuan-Chuan Tai.

Subjects/Keywords: Broken ray transform; Computed tomography; Inverse problems; Iterative methods; X-ray scattering; Electrical and Electronics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walker, M. R. (2020). Joint Estimation of Attenuation and Scatter for Tomographic Imaging with the Broken Ray Transform. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/554

Chicago Manual of Style (16^th Edition):

Walker, Michael Ray. “Joint Estimation of Attenuation and Scatter for Tomographic Imaging with the Broken Ray Transform.” 2020. Doctoral Dissertation, Washington University in St. Louis. Accessed March 01, 2021. https://openscholarship.wustl.edu/eng_etds/554.

MLA Handbook (7^th Edition):

Walker, Michael Ray. “Joint Estimation of Attenuation and Scatter for Tomographic Imaging with the Broken Ray Transform.” 2020. Web. 01 Mar 2021.

Vancouver:

Walker MR. Joint Estimation of Attenuation and Scatter for Tomographic Imaging with the Broken Ray Transform. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2020. [cited 2021 Mar 01]. Available from: https://openscholarship.wustl.edu/eng_etds/554.

Council of Science Editors:

Walker MR. Joint Estimation of Attenuation and Scatter for Tomographic Imaging with the Broken Ray Transform. [Doctoral Dissertation]. Washington University in St. Louis; 2020. Available from: https://openscholarship.wustl.edu/eng_etds/554

Washington University in St. Louis

29. Shang, Wenjie. Development and Application of Elliptic Blending Lag k-omega SST Standard and Wall-Distance-Free Turbulence Model.

Degree: MS, Mechanical Engineering & Materials Science, 2020, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/527

► In recent decades, Computational Fluid Dynamics (CFD) has become the most widely used technology to understand the fundamental complex fluid dynamics of turbulent flows as… (more)

Subjects/Keywords: Turbulence Modeling; Elliptic Blending; k-ω SST Model; Lag Equation; Aerodynamics and Fluid Mechanics; Engineering; Heat Transfer, Combustion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shang, W. (2020). Development and Application of Elliptic Blending Lag k-omega SST Standard and Wall-Distance-Free Turbulence Model. (Thesis). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/527

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shang, Wenjie. “Development and Application of Elliptic Blending Lag k-omega SST Standard and Wall-Distance-Free Turbulence Model.” 2020. Thesis, Washington University in St. Louis. Accessed March 01, 2021. https://openscholarship.wustl.edu/eng_etds/527.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shang, Wenjie. “Development and Application of Elliptic Blending Lag k-omega SST Standard and Wall-Distance-Free Turbulence Model.” 2020. Web. 01 Mar 2021.

Vancouver:

Shang W. Development and Application of Elliptic Blending Lag k-omega SST Standard and Wall-Distance-Free Turbulence Model. [Internet] [Thesis]. Washington University in St. Louis; 2020. [cited 2021 Mar 01]. Available from: https://openscholarship.wustl.edu/eng_etds/527.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shang W. Development and Application of Elliptic Blending Lag k-omega SST Standard and Wall-Distance-Free Turbulence Model. [Thesis]. Washington University in St. Louis; 2020. Available from: https://openscholarship.wustl.edu/eng_etds/527

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

30. Dunham, Chelsey. The Mechanobiology of Elbow Contracture: Pathogenesis and Prevention.

Degree: PhD, Biomedical Engineering, 2020, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/541

► Post-traumatic elbow contracture is a multi-tissue pathology which develops in up to 50% of patients following elbow trauma (e.g., fracture, dislocation). It is unclear which… (more)

▼ Post-traumatic elbow contracture is a multi-tissue pathology which develops in up to 50% of patients following elbow trauma (e.g., fracture, dislocation). It is unclear which periarticular soft tissues are driving the functional deficit following injury because it is not possible in clinical settings to isolate each soft tissues’ mechanical and biological contributions to elbow contracture. Therefore, an animal model is needed to identify the primary periarticular soft tissue(s) which contribute to contracture. The first animal models of contracture were developed in the knee; however, these studies are not generalizable to the elbow due to anatomical and functional differences between these two joints. Thus, we developed a model of post-traumatic elbow contracture in the rat and can now investigate each periarticular soft tissues’ contribution to motion loss, which will ultimately inform the development of tissue targeted treatment strategies. Current strategies to manage elbow contracture (e.g., physical therapy, surgery) rarely restore range-of-motion to pre-injury levels. These strategies are often not effective because they physically disrupt the periarticular soft tissues rather than treat the underlying pathology. Previously, stem cells have been used in animal models of soft tissue fibrosis in an effort to prevent tissue hypertrophy and functional loss. However, these treatments exhibited unpredictable results which ranged from transient benefits to amplified pathology. Hence, a mechanism is needed to improve stem cell efficacy following injection. In this work, mechanical memory will be used to direct stem cells toward positively influencing tissue regeneration in vivo. The studies presented in this dissertation aimed (1) to evaluate mechanical and biological changes in the periarticular soft tissues from our rat model of elbow contracture to ultimately identify the primary contributor(s) to motion loss, and (2) to determine in vitro if adipose-derived stem cells (ASCs) exhibit mechanical memory and to examine if treatment with soft primed ASCs will reduce fibrosis and improve elbow function in our rat model after injury. Following injury, flexion-extension and pronation-supination developed motion loss differently throughout immobilization and uniquely responded to joint reloading during subsequent free mobilization in our rat elbow contracture model. However, the motion lost was more severe in flexion-extension than in pronation-supination. The anterior capsule, ligaments, and cartilage were identified as the primary contributors to contracture in flexion-extension. Physiological testing confirmed that muscle was not a permanent contributor to elbow contracture in our rat model. Biological characterization of the anterior capsule and lateral collateral ligament identified that hypertrophy as a result of fibrosis likely caused the deficit in joint mechanics. To prevent fibrosis in these tissues, a biological treatment strategy was developed using mechanically primed ASCs. Soft primed ASCs displayed a… Advisors/Committee Members: Spencer Lake, Gretchen Meyer, Aaron Chamberlain, Amit Pathak, Lori Setton.

Subjects/Keywords: Biomedical Engineering and Bioengineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dunham, C. (2020). The Mechanobiology of Elbow Contracture: Pathogenesis and Prevention. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/541

Chicago Manual of Style (16^th Edition):

Dunham, Chelsey. “The Mechanobiology of Elbow Contracture: Pathogenesis and Prevention.” 2020. Doctoral Dissertation, Washington University in St. Louis. Accessed March 01, 2021. https://openscholarship.wustl.edu/eng_etds/541.

MLA Handbook (7^th Edition):

Dunham, Chelsey. “The Mechanobiology of Elbow Contracture: Pathogenesis and Prevention.” 2020. Web. 01 Mar 2021.

Vancouver:

Dunham C. The Mechanobiology of Elbow Contracture: Pathogenesis and Prevention. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2020. [cited 2021 Mar 01]. Available from: https://openscholarship.wustl.edu/eng_etds/541.

Council of Science Editors:

Dunham C. The Mechanobiology of Elbow Contracture: Pathogenesis and Prevention. [Doctoral Dissertation]. Washington University in St. Louis; 2020. Available from: https://openscholarship.wustl.edu/eng_etds/541

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Open Access Theses and Dissertations