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University of
California – Santa Cruz
1.
Heady, Walter Nicholas.
Relationships among environment,
movement, growth and survival of coastal rainbow trout
(Oncorhynchus mykiss).
Degree: Ecology and Evolutionary Biology, 2012, University of
California – Santa Cruz
URL: http://www.escholarship.org/uc/item/7vx0z1ms 
► Individuals of the same species can vary dramatically in their size, physiology or behavior, thereby influencing their movement, growth and survival. Through influencing demographics individual…
(more)
▼ Individuals of the same species
can vary dramatically in their size, physiology or behavior,
thereby influencing their movement, growth and survival. Through
influencing demographics individual variation is important to
population resilience in the face of environmental change in space
and time. Understanding the ecological consequences of individual
and population variation is timely considering the dramatic rates
of extinction and anthropogenic alterations we are witnessing
including global climate change. Coastal rainbow trout
(Oncorhynchus
mykiss) express a dizzying range of
variability in movement and growth rate. I used acoustic telemetry
to determine the diversity of O.
mykiss movement patterns in an altered
river. Movement distance and frequency ranged widely from no
movement over the 218d study period to traveling 170km to the
Pacific Ocean in 14d. However, most individuals did not move more
than 0.5km. Movement correlated with size, season and location.
Mortality correlated with the number of moves rather than distance
moved suggesting movement regardless of scale influenced survival.
In laboratory experiments I found more northerly
O. mykiss
populations had growth optimals at colder temperatures than more
southerly populations. However, temperature-dependent growth varied
among populations at very local scales. Temperatures previously
experienced did not affect temperature-dependent growth which is
beneficial for a species that may experience dramatic fluctuations
in temperature through space and time. I used a diet-switch
experiment and model fitting to quantify the nitrogen isotope
tissue turnover rate and discrimination factor for seven
O. mykiss tissues.
Among seven tissues, diet-tissue δ15N discrimination
factors ranged from 1.3 to 3.4 /. Model supported tissue turnover
half-lives ranged from 9.0 to 27.7 days. Using parameter estimates
and their uncertainty, I developed stable isotope clocks to
estimate the time since resource-shifts. A greater understanding of
the extent and importance of individual and population-level
variation in fundamental demographic (i.e. growth and survival) and
life history (i.e. anadromy and thermal optima) parameters is key
to the management and conservation of threatened species. This
research revealed that O.
mykiss populations vary in these
fundamental parameters, implying the importance of local-scale
management and conservation practices that ensure the continued
diversity of these parameters within and among populations.
Subjects/Keywords: Ecology; Fisheries and aquatic
sciences; individual; population; stable isotopes; telemetry;
temperature-dependent; variation
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APA (6th Edition):
Heady, W. N. (2012). Relationships among environment,
movement, growth and survival of coastal rainbow trout
(Oncorhynchus mykiss). (Thesis). University of
California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/7vx0z1ms
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Heady, Walter Nicholas. “Relationships among environment,
movement, growth and survival of coastal rainbow trout
(Oncorhynchus mykiss).” 2012. Thesis, University of
California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/7vx0z1ms.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Heady, Walter Nicholas. “Relationships among environment,
movement, growth and survival of coastal rainbow trout
(Oncorhynchus mykiss).” 2012. Web. 01 Mar 2021.
Vancouver:
Heady WN. Relationships among environment,
movement, growth and survival of coastal rainbow trout
(Oncorhynchus mykiss). [Internet] [Thesis]. University of
California – Santa Cruz; 2012. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/7vx0z1ms.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Heady WN. Relationships among environment,
movement, growth and survival of coastal rainbow trout
(Oncorhynchus mykiss). [Thesis]. University of
California – Santa Cruz; 2012. Available from: http://www.escholarship.org/uc/item/7vx0z1ms
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of
California – Santa Cruz
2.
Yeakel, Justin Douglas.
The structure of mammalian
food-webs: interpreting, predicting, and informing estimates of
species interactions in paleontological and modern
communities.
Degree: Ecology and Evolutionary Biology, 2012, University of
California – Santa Cruz
URL: http://www.escholarship.org/uc/item/7z7173b4
► Patterns of species interactions are both the cause and consequence of ecosystem dy- namics. Understanding the origin and function of specific interaction patterns at the…
(more)
▼ Patterns of species
interactions are both the cause and consequence of ecosystem dy-
namics. Understanding the origin and function of specific
interaction patterns at the ecosystem scale has been a long-term
goal in ecology. These efforts are often limited by the enormous
size of biological systems, the temporal transience of ecological
inter- actions, difficulties in obtaining reliable measurements
[3], knowing what is important to measure in the first place, and
the time-scale over which observations are made. In the following
chapters, I first introduce a probabilistic framework to
incorporate field- measured (rather than experimental) strengths of
interactions between species using stable isotope data. This
framework provides a means to examine whether different variance
structures are predictive of specific interaction patterns, such as
nestedness and modularity. Secondly, to assess the impact of global
climatic perturbations on mammalian communities over long time
scales, I use stable isotope ratios of predators and prey to
examine six independent paleontological communities ranging from
Europe to Beringia and spanning the Last Glacial Maximum. Both the
temporal and spatial evolution of species-specific relationships,
as well as community-scale structures, are investigated to
understand how changes in climate and prey abundance [99]
influenced trophic interactions in the late Pleistocene. Although
Chapters 1 and 2 concern large- scale emergent properties of
food-webs, I introduce in Chapter 3 a process-based model designed
to investigate the effects of mechanical constraints on the
foraging strategies of anthropoid primates, and early hominins in
particular. Although this model serves primarily as a predictive
tool, towards the end of Chapter 3 I discuss how it can be used
instead to inform independent estimates of diet, which may be
particularly useful in a paleontological context where data are
limited. Finally, in Chapter 4, I extend upon this reasoning and
introduce a method by which resource availability data and mixing
space geometry can be used to update estimates of trophic
interactions from Bayesian isotope mixing models, and demonstrate
its utility using data from a New Zealand intertidal community. The
four chapters presented here introduce techniques and frameworks by
which stable isotopes, statistical mechanics of networks, and
process-based models can be used to investigate both the formation
and time evolution of the patterns of species interactions in
ecological communities.
Subjects/Keywords: Ecology; Paleoecology;
Biogeochemistry; Food-webs; Foraging behavior; Mammoth Steppe;
Predator-prey networks; Stable isotopes; Stochastic dynamic
programming
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APA ·
Chicago ·
MLA ·
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CSE |
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yeakel, J. D. (2012). The structure of mammalian
food-webs: interpreting, predicting, and informing estimates of
species interactions in paleontological and modern
communities. (Thesis). University of
California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/7z7173b4
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Yeakel, Justin Douglas. “The structure of mammalian
food-webs: interpreting, predicting, and informing estimates of
species interactions in paleontological and modern
communities.” 2012. Thesis, University of
California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/7z7173b4.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Yeakel, Justin Douglas. “The structure of mammalian
food-webs: interpreting, predicting, and informing estimates of
species interactions in paleontological and modern
communities.” 2012. Web. 01 Mar 2021.
Vancouver:
Yeakel JD. The structure of mammalian
food-webs: interpreting, predicting, and informing estimates of
species interactions in paleontological and modern
communities. [Internet] [Thesis]. University of
California – Santa Cruz; 2012. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/7z7173b4.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Yeakel JD. The structure of mammalian
food-webs: interpreting, predicting, and informing estimates of
species interactions in paleontological and modern
communities. [Thesis]. University of
California – Santa Cruz; 2012. Available from: http://www.escholarship.org/uc/item/7z7173b4
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
3.
Alley, Richard Jason.
When You're 64: Publics, Aging and Community in San Francisco.
Degree: Anthropology, 2012, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/9jv507mc
► This dissertation investigates the politics of aging in the contemporary United States vis-à-vis welfare work, public spheres and everyday life. As a quick glance at…
(more)
▼ This dissertation investigates the politics of aging in the contemporary United States vis-à-vis welfare work, public spheres and everyday life. As a quick glance at any recent news headline will reveal, the demographic realities of an aging population has become a pressing concern for policymakers, families and communities throughout the United States. From documentaries about Alzheimer's disease to debates around pension reform, old age has captured the collective imaginary with uncanny zeal. A city often identified with its bohemian youth culture, San Francisco is home to the largest urban older adult population in the state of California, approximately 14% of who are over the age of 65. For many residents, migration to retirement communities is either financially out of reach or socially undesirable, creating a new set of realities whereby seniors opt to "age in place." Based on a year and a half of ethnographic fieldwork from 2009 to 2010 with a coalition of organizations focusing on queer aging, a group of seniors forming a nascent care network amongst one another as well as interviews with older San Franciscans, I examine the aging publics and lifeworlds coming into being in one American city. Throughout, I argue that aging offers a lens through which to analyze competing visions of American modernity – one vision focusing on individuality and independence, another stressing the importance of community and connection.
Subjects/Keywords: Cultural anthropology; Aging; American studies
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APA (6th Edition):
Alley, R. J. (2012). When You're 64: Publics, Aging and Community in San Francisco. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/9jv507mc
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alley, Richard Jason. “When You're 64: Publics, Aging and Community in San Francisco.” 2012. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/9jv507mc.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alley, Richard Jason. “When You're 64: Publics, Aging and Community in San Francisco.” 2012. Web. 01 Mar 2021.
Vancouver:
Alley RJ. When You're 64: Publics, Aging and Community in San Francisco. [Internet] [Thesis]. University of California – Santa Cruz; 2012. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/9jv507mc.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alley RJ. When You're 64: Publics, Aging and Community in San Francisco. [Thesis]. University of California – Santa Cruz; 2012. Available from: http://www.escholarship.org/uc/item/9jv507mc
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
4.
Tucker, Matthew Alan.
Building Verbs in Maltese.
Degree: Linguistics, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/00x5x9wz
► This dissertation examines the morphosyntactic implications of verb-building in the Semitic language Maltese. Theoretically, the dissertation examines the role of functional heads in defining clausal…
(more)
▼ This dissertation examines the morphosyntactic implications of verb-building in the Semitic language Maltese. Theoretically, the dissertation examines the role of functional heads in defining clausal morphosyntactic properties and the interaction of syntax and morphology in the domain of cliticization. The phenomena examined herein are: (i) the major clausal constituency of Maltese and the derivation of subject agreement morphology in periphrastic complex tense constructions, (ii) morphological and periphrastic causative formation and the absence of non-finite verb forms, (iii) the argument structure of ditransitives and the syntax of cliticization, and (iv) the implications of ditransitive argument structure as it pertains to analyses of the Person Case Constraint. The dissertation shows that these phenomena support a view of syntax wherein lexical properties of heads determine agreement morphology and the structure of clausal complements and a view of morphology wherein morphological constraints can influence the output of syntactic computation.I show that a pervasive feature of Maltese is the appearance of phi−features on lexical items which would be devoid of phi−features in other languages. Data from floating quantification and word order in complex tense constructions are used to argue that verbs in periphrastic tense constructions receive agreement features via successive-cyclic movement of the subject through intermediate specifier positions. Data from available morphology and adverbial interpretation are presented which suggests that periphrastic causatives in Maltese em- bed a reduced clause wherein a polarity phrase may host agreement features, accounting for finite verb forms in semantically non-finite causative complements. Moreover, agreement and case are argued to be computed distinctly, given that causative subjects appear with accusative case yet still trigger subject agreement on the complement predicate. I show that while Agree can account for subject agreement in the usual way, the Maltese causative facts necessitate pairing Agree with a theory of case in which morphological case values are assigned disjunctively based on the number of nominals in a clause.I also show that Maltese non-causative ditransitives bifurcate into two distinct classes: (i) a majority class which only allows prepositional dative constructions and (ii) a minority, lexically idiosyncratic class which allows a limited double object construction involving two accusatives. I show that these facts can be accounted for by positing a VP-movement in these ditransitives which interacts with structural Case licensing to derive the appearance of a restricted double accusative case frame.Finally, I show that data from potential intervention contexts require treat- ing cliticization in Maltese as an instance of head movement of a simultaneously minimal and maximal determiner element. This view of cliticization is shown to be more appropriate than phrasal movement for the Maltese facts insofar as it correctly predicts that…
Subjects/Keywords: Linguistics; generative grammar; linguistics; Maltese; theoretical morphology; theoretical syntax
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tucker, M. A. (2013). Building Verbs in Maltese. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/00x5x9wz
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tucker, Matthew Alan. “Building Verbs in Maltese.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/00x5x9wz.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tucker, Matthew Alan. “Building Verbs in Maltese.” 2013. Web. 01 Mar 2021.
Vancouver:
Tucker MA. Building Verbs in Maltese. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/00x5x9wz.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tucker MA. Building Verbs in Maltese. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/00x5x9wz
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
5.
LaRiviere, Jonathan Paul.
The evolution of North Pacific climate since the late Miocene.
Degree: Ocean Sciences, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/0160s19c
► A lack of paleo-proxy data has made it difficult to determine the mechanisms responsible for the warm climates of the late Miocene and early Pliocene.…
(more)
▼ A lack of paleo-proxy data has made it difficult to determine the mechanisms responsible for the warm climates of the late Miocene and early Pliocene. Though modeling work suggests that the global distribution of sea surface temperatures (SSTs) and the depth of the global thermocline may have been important to maintaining past warm climates, paleoceanographic data is needed to test these ideas. This dissertation uses geochemical proxy reconstructions of SST, thermocline depth, and precipitation from North Pacific sediments to test the role that the oceans played in shaping late Miocene and Pliocene climates. Chapter 2 uses alkenone paleothermometry and d18O of planktonic foraminifera to show that the SSTs of the mid-latitude North Pacific ~13-5 Ma were decoupled from atmospheric pCO2, possibly due to a deeper-than-modern global thermocline. The data indicates that thermocline shoaling after ~5 Ma, possibly related to changes in ocean basin shape, led to a stronger coupling between SSTs and atmospheric pCO2 in more recent epochs. Chapter 3 uses new alkenone and Mg/Ca SSTs with published SST estimates to test the importance of SST gradients in the warm late Miocene and early Pliocene. Kriging of SST data was used to construct maps of late Miocene, Pliocene, and Pleistocene time-slices. The results, which show that basin-wide SST gradients were weak (relative to modern) in the early Pliocene but even weaker during the late Miocene, support the hypothesis that weak SST gradients contributed to warm global temperatures. Chapter 4 assesses the utility of the dDn-alkanes in marine sediments as a proxy of precipitation on the continents. Ground-truthing of California Margin core tops indicated that dDn-alkanes from southern California Margin sediments are suitable for down-core reconstructions of past precipitation. Additionally, a low-resolution dDn-alkanes record generated for this study showed that the establishment of the modern mediterranean climate in southern California might have resulted from the SST changes described in Chapters 2 and 3. Overall, this dissertation shows that reconstructions of past oceanographic and climate conditions of the North Pacific support the hypothesis that SST gradients played a major role in shaping the warm climates of the early Pliocene and late Miocene.
Subjects/Keywords: Paleoclimate science; Geochemistry; Geology; alkenone; isotope; Miocene; Pliocene; sea surface temperatures; thermocline
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
LaRiviere, J. P. (2013). The evolution of North Pacific climate since the late Miocene. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/0160s19c
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
LaRiviere, Jonathan Paul. “The evolution of North Pacific climate since the late Miocene.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/0160s19c.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
LaRiviere, Jonathan Paul. “The evolution of North Pacific climate since the late Miocene.” 2013. Web. 01 Mar 2021.
Vancouver:
LaRiviere JP. The evolution of North Pacific climate since the late Miocene. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/0160s19c.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
LaRiviere JP. The evolution of North Pacific climate since the late Miocene. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/0160s19c
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
6.
Peach, Kelly Corbus.
Image-Based Screening in Vibrio Cholerae: Platform Development, Image Analysis, and Small Molecule Biofilm Modulators.
Degree: Chemistry, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/01n3f97j
► This dissertation describes the development and application of a high-throughput, image-based screening platform for the discovery of small molecules with activity against Vibrio cholerae. Like…
(more)
▼ This dissertation describes the development and application of a high-throughput, image-based screening platform for the discovery of small molecules with activity against Vibrio cholerae. Like many bacterial species, V. cholerae is capable of forming three-dimensional biofilms. Biofilm-mediated infections are prevalent in the clinic, and bacteria in the biofilm state are 10-10,000 fold less susceptible to antibiotic treatment than bacteria in the planktonic state. Despite the pervasiveness of these diseases there are no existing therapeutics for combatting these infections, nor is there a complete understanding of the molecular mechanisms that control biofilm formation. In order to address this problem, a wide range of techniques were utilized including high-throughput screening (UCSC Chemical Screening Center), image analysis tools, and structure elucidation methods. Chapter 1 provides a history of bacterial biofilms, the role of biofilms in human disease, and the existing small molecules with reported biofilm inhibitory activity. The second chapter describes the development of an image-based, 384-well format platform for investigating the effects of small molecules upon a biofilm forming strain of V. cholerae. The chapter closes with the validation of this assay through the screening of a 5,080 member commercial library. Chapter 3 reports the results from a large scale screening campaign investigating both commercial and marine natural product (NP) libraries. The final half of the chapter details the development of two secondary screening platforms designed for the evaluation of small scale quantities of compound, allowing for characterization of pure natural products produced in low titer beyond the primary screening stage. Chapter 4 describes the discovery, isolation, structure elucidation, and biological characterization of a novel biofilm inhibitor. This compound, previously reported as the chromophore of auromomycin, displays a unique biofilm inhibitory phenotype indicating that the mechanism through which this molecule disrupts biofilm formation is unique compared to the previous compounds discovered using this screening platform. The final chapter departs from the subject of biofilm inhibition, and concentrates on the effects of a known antibacterial training set and our natural product extract libraries on V. cholerae morphology. The development of a novel image analysis platform allowed for the quantification of cellular morphologies caused by compound treatment. The results from screening a dilution series of a set of known antibiotics indicated that the compounds can be binned based on their broad modes of action. This is the first example of a high-content bacterial screen, and has allowed for the mechanism-based profiling of NP extracts with unknown chemical constitution.
Subjects/Keywords: Chemistry; biofilm inhibitor; drug discovery; image-based screening; natural products; Vibrio cholerae
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Peach, K. C. (2013). Image-Based Screening in Vibrio Cholerae: Platform Development, Image Analysis, and Small Molecule Biofilm Modulators. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/01n3f97j
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Peach, Kelly Corbus. “Image-Based Screening in Vibrio Cholerae: Platform Development, Image Analysis, and Small Molecule Biofilm Modulators.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/01n3f97j.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Peach, Kelly Corbus. “Image-Based Screening in Vibrio Cholerae: Platform Development, Image Analysis, and Small Molecule Biofilm Modulators.” 2013. Web. 01 Mar 2021.
Vancouver:
Peach KC. Image-Based Screening in Vibrio Cholerae: Platform Development, Image Analysis, and Small Molecule Biofilm Modulators. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/01n3f97j.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Peach KC. Image-Based Screening in Vibrio Cholerae: Platform Development, Image Analysis, and Small Molecule Biofilm Modulators. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/01n3f97j
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
7.
Chavez, Xochitl Consuelo.
Migrating Performative Traditions: The Guelaguetza Festival In Oaxacalifornia.
Degree: Anthropology (Latin American and Latino Studies), 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/029764fs
► Migrating Performative Traditions: La Guelaguetza Festival in Oaxacalifornia, offers an comprehensive study of the Guelaguetza festival, an indigenous Oaxacan transborder cultural performance. Recognizing that festivals…
(more)
▼ Migrating Performative Traditions: La Guelaguetza Festival in Oaxacalifornia, offers an comprehensive study of the Guelaguetza festival, an indigenous Oaxacan transborder cultural performance. Recognizing that festivals are important sites through which cultural ideals and values are displayed, transmitted, and reproduced or challenged, I conducted original ethnographic research over an eight-year period to produce the first transnational study of the Guelaguetza festival. My research not only analyzes the production of the festival in Oaxaca City, but also follows the same migratory route of Oaxaqueño migrants across what many scholars have called, Oaxacalifornia in order to document the multiple re-productions of the Guelaguetza festival on different social terrains, specifically Los Angeles and Santa Cruz, California. Producing this elaborate festival requires a tremendous amount of labor, time and resources. Therefore, one of my principal concerns in this dissertation was to explore why and how Oaxacan migrants produce their own Guelaguetzas in California and to understand what the festival means to the people and community. By juxtaposing the Guelaguetza festivals in Los Ángeles and Santa Cruz, I highlight how Oaxacan migrants first devised it as a creative way to claim cultural citizenship in California and Oaxaca, and then came to use it to counteract racism, discrimination and gang violence. Over the course of my research, I have come to appreciate how the migrant-produced Guelaguetza festivals offers insight on the negotiations of indigenous migrants' daily experiences and the process in constructing a sense of community in new geographical locations. The Oaxacan migrant community's ability to sponsor the festival in the United demonstrates that the migrant communities have established themselves within the political and cultural landscapes of California. In sum, this study offers a window into how indigenous working-class migrant communities with limited resources navigate new bureaucratic structures, cultural norms, and public spaces to maintain and assert their cultural identities in a transnational context.
Subjects/Keywords: Cultural anthropology; Latin American studies; Native American studies; cultural performance; Guelaguetza Festival; Indigenous Mexican Migrants; Oaxaca; Transnational migration
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APA ·
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MLA ·
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APA (6th Edition):
Chavez, X. C. (2013). Migrating Performative Traditions: The Guelaguetza Festival In Oaxacalifornia. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/029764fs
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chavez, Xochitl Consuelo. “Migrating Performative Traditions: The Guelaguetza Festival In Oaxacalifornia.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/029764fs.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chavez, Xochitl Consuelo. “Migrating Performative Traditions: The Guelaguetza Festival In Oaxacalifornia.” 2013. Web. 01 Mar 2021.
Vancouver:
Chavez XC. Migrating Performative Traditions: The Guelaguetza Festival In Oaxacalifornia. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/029764fs.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chavez XC. Migrating Performative Traditions: The Guelaguetza Festival In Oaxacalifornia. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/029764fs
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
8.
Crest, Justin Matthew.
REGULATION OF CORTICAL ACTIN DYNAMICS DURING CENTROSOME SEPARATION AND CYTOKINESIS IN THE DROSOPHILA EMBRYO.
Degree: Molecular Cell and Developmental Biology, 2012, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/30w6j1wx
► The cytoskeleton plays a variety of roles during the cell cycle, none more dramatic than the formation of a bipolar mitotic spindle and the subsequent…
(more)
▼ The cytoskeleton plays a variety of roles during the cell cycle, none more dramatic than the formation of a bipolar mitotic spindle and the subsequent cleavage of one cell into two. Proper centrosome separation is a prerequisite for positioning the bipolar spindle. Although studies demonstrate that microtubules and their associated motors drive centrosome separation, the role of actin in centrosome separation remains less clear. Studies in tissue culture cells indicate that actin- and myosin-based cortical flow is primarily responsible for driving late centrosome separation, whereas other studies suggest that actin plays a more passive role by serving as an attachment site for astral microtubules to pull centrosomes apart. Here we demonstrate that prior to nuclear envelope breakdown (NEB) in Drosophila embryos; proper centrosome separation does not require myosin II but requires dynamic actin rearrangements at the growing edge of the interphase cap. Both Arp2/3- and Formin-mediated actin remodeling are required for separating the centrosome pairs before NEB. The Apc2-Armadillo complex appears to link cap expansion to centrosome separation. In contrast, the mechanisms driving centrosome separation after NEB are dependent of the actin cytoskeleton and compensate for earlier separation defects. Our studies show that the dynamics of actin polymerization drive centrosome separation and this has important implications for centrosome positioning during processes such as cell migration, cell polarity maintenance, and asymmetric cell division. Another vital role for spindle formation is in positioning the site of cleavage following anaphase separation of DNA. Rappaport's experiments with sand dollar embryos showed that cleavage furrow positioning is determined by the relationship between the spindle and the actin cortex. In his embryos, astral microtubules, which extend out to the cortex were primarily responsible for initiating a furrow, however, smaller somatic cells seem to position the furrow through the overlapping antiparallel central spindle. This balance between astral and central spindle influences is not well understood however. In the early Drosophila embryo, nuclei divide within a syncytium yet invaginate cortical actin and membrane, encompassing them, in order to complete mitosis in close proximity to neighboring nuclei. These furrows are considered natural Rappaport furrows since they form at astral microtubule overlap. Upon cellularization, the furrow positioning seems to shift from astral microtubule-based to central spindle-based. Our findings show that during the syncytial divisions, key conserved central spindle components Centralspindlin complex, Polo, and Fascetto (Prc1) all localize to regions of overlap astral microtubules during furrow formation. Given that the central spindle does not induce formation of conventional cytokinesis, finding that all of these components, plus the chromosomal passenger complex (Aurora B and INCENP), also localize to the central spindle was unexpected. The lack of furrow…
Subjects/Keywords: Cellular biology; Cytokinesis
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APA (6th Edition):
Crest, J. M. (2012). REGULATION OF CORTICAL ACTIN DYNAMICS DURING CENTROSOME SEPARATION AND CYTOKINESIS IN THE DROSOPHILA EMBRYO. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/30w6j1wx
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Crest, Justin Matthew. “REGULATION OF CORTICAL ACTIN DYNAMICS DURING CENTROSOME SEPARATION AND CYTOKINESIS IN THE DROSOPHILA EMBRYO.” 2012. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/30w6j1wx.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Crest, Justin Matthew. “REGULATION OF CORTICAL ACTIN DYNAMICS DURING CENTROSOME SEPARATION AND CYTOKINESIS IN THE DROSOPHILA EMBRYO.” 2012. Web. 01 Mar 2021.
Vancouver:
Crest JM. REGULATION OF CORTICAL ACTIN DYNAMICS DURING CENTROSOME SEPARATION AND CYTOKINESIS IN THE DROSOPHILA EMBRYO. [Internet] [Thesis]. University of California – Santa Cruz; 2012. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/30w6j1wx.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Crest JM. REGULATION OF CORTICAL ACTIN DYNAMICS DURING CENTROSOME SEPARATION AND CYTOKINESIS IN THE DROSOPHILA EMBRYO. [Thesis]. University of California – Santa Cruz; 2012. Available from: http://www.escholarship.org/uc/item/30w6j1wx
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
9.
Hirschi, Alexander.
Structural and mechanistic insights into the regulation of cellular quiescence by Rb and p130.
Degree: Molecular Cell and Developmental Biology, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/0qx721kp
► The ability of a single cell to grow, replicate its genetic material, and divide into two identical daughter cells is a vital process to ensure…
(more)
▼ The ability of a single cell to grow, replicate its genetic material, and divide into two identical daughter cells is a vital process to ensure the propagation of all life. This process is known as the cell division cycle (cell cycle) and is one of the most highly spatially and temporally regulated cellular processes. Misregulation of the cell cycle, particularly in ways that confer both a proliferative advantage and escape from ultimate growth control mechanisms like cellular senescence or apoptosis, can result in unrestrained cell division and tumor formation. In this study, I utilize structural biology, biochemistry, and biophysical data to demonstrate a novel mechanism regulating Rb phosphorylation state and to map pairwise interactions in a conserved cell-cycle regulatory complex called the MuvB Core. First, competition between CDK and PP1 for Rb access provides an efficient regulatory mechanism to dephosphorylate Rb during mitotic exit and times of genotoxic stress. Second, data is presented mapping domain contacts in the MuvB Core, and structure/function studies with MuvB Core suggest an atypical function in regulation of chromatin structure.
Subjects/Keywords: Biology
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APA (6th Edition):
Hirschi, A. (2013). Structural and mechanistic insights into the regulation of cellular quiescence by Rb and p130. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/0qx721kp
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hirschi, Alexander. “Structural and mechanistic insights into the regulation of cellular quiescence by Rb and p130.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/0qx721kp.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hirschi, Alexander. “Structural and mechanistic insights into the regulation of cellular quiescence by Rb and p130.” 2013. Web. 01 Mar 2021.
Vancouver:
Hirschi A. Structural and mechanistic insights into the regulation of cellular quiescence by Rb and p130. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/0qx721kp.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hirschi A. Structural and mechanistic insights into the regulation of cellular quiescence by Rb and p130. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/0qx721kp
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
10.
Kenney, Martha.
Fables of Attention: Wonder in Feminist Theory and Scientific Practice.
Degree: History of Consciousness, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/14q7k1jz
► Fables of attention are didactic stories about the consequences of how we attend to the world. They act on our sensoria; they teach us how…
(more)
▼ Fables of attention are didactic stories about the consequences of how we attend to the world. They act on our sensoria; they teach us how to pay attention. In this dissertation, which is located in the field of Science and Technology Studies (STS), I use the genre of the fable to explore the relationship between attention and storytelling across different ecologies of practice. Specifically, I focus on wonder as a mode of attention in feminist theory and scientific practice. As I read and write fables of attention, wonder does not stay still; it transforms and accrues different meanings as the chapters unfold.Chapter 1 looks at wonder as epistemological dilation in the scientific articles of American ichthyologist E.W. Gudger (1866-1965), showing how it shaped his scientific objects and guided his passionate empiricism. Chapter 2 tells the story of how STS scholar Helen Verran shifts her mode of attention from wonder to disconcertment as she struggles to remain accountable for the colonial inheritances of her knowledge-making practices. In Chapter 3 I return to wonder, refiguring it for speculative feminist theory. Isabelle Stengers is my guide as I read speculative wonder into the work of iconoclastic evolutionary biologists Joan Roughgarden and Lynn Margulis. Here wonder helps me to consider how to tell more responsive and response-able stories about life. The Conclusion is about thinking with aesthetics, the arts of enchantment, and the promise of an illuminated wonder.Following in the tradition of feminist science studies, each of these chapters is guided by the cosmopolitical question: "What kinds of attention can foster more livable, breathable technoscientific worlds?"
Subjects/Keywords: Epistemology; Literature; Attention; Fables; Feminist Theory; Science and Technology Studies; Wonder
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APA ·
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APA (6th Edition):
Kenney, M. (2013). Fables of Attention: Wonder in Feminist Theory and Scientific Practice. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/14q7k1jz
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kenney, Martha. “Fables of Attention: Wonder in Feminist Theory and Scientific Practice.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/14q7k1jz.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kenney, Martha. “Fables of Attention: Wonder in Feminist Theory and Scientific Practice.” 2013. Web. 01 Mar 2021.
Vancouver:
Kenney M. Fables of Attention: Wonder in Feminist Theory and Scientific Practice. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/14q7k1jz.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kenney M. Fables of Attention: Wonder in Feminist Theory and Scientific Practice. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/14q7k1jz
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
11.
Kravtchenko, Ekaterina.
Effects of contextual predictability on optional subject omission in Russian.
Degree: Linguistics, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1fc8s7jx
► The role of contextual predictability in language processing and production has gained increasing attention in recent years, but in production remains relatively understudied above the…
(more)
▼ The role of contextual predictability in language processing and production has gained increasing attention in recent years, but in production remains relatively understudied above the phonetic/phonological levels. Further, the existence and source of predictability effects is still contested, and it remains unclear which phenomena these effects extend to, as well as what their explanatory range is (Jurafsky, 2003). I present two experiments which investigate the role of contextual predictability in the choice to omit optional subjects in Russian. The results demonstrate that when other predictors of referential expression choice are taken into account, contextual predictability, conditioned on preceding context, remains a significant predictor of whether an optional subject is pronounced or elided in colloquial text or speech. Contextual predictability conditioned on following context, in contrast, does not appear to exert significant influence after effects of preceding context are controlled for.
Subjects/Keywords: Linguistics
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APA ·
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to Zotero / EndNote / Reference
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APA (6th Edition):
Kravtchenko, E. (2013). Effects of contextual predictability on optional subject omission in Russian. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1fc8s7jx
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kravtchenko, Ekaterina. “Effects of contextual predictability on optional subject omission in Russian.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1fc8s7jx.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kravtchenko, Ekaterina. “Effects of contextual predictability on optional subject omission in Russian.” 2013. Web. 01 Mar 2021.
Vancouver:
Kravtchenko E. Effects of contextual predictability on optional subject omission in Russian. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1fc8s7jx.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kravtchenko E. Effects of contextual predictability on optional subject omission in Russian. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/1fc8s7jx
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
12.
Kmet, Muriel Marie.
Differentiation of human embryonic stem cells into Corticofugal projection neurons.
Degree: Molecular Cell and Developmental Biology, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1jp080qr
► Understanding how neuronal diversity is achieved within the cerebral cortex remains a major challenge in neuroscience. The surge of human embryonic stem cells (hESCs) as…
(more)
▼ Understanding how neuronal diversity is achieved within the cerebral cortex remains a major challenge in neuroscience. The surge of human embryonic stem cells (hESCs) as a novel model system provides a unique opportunity to study human corticogenesis in vitro and€ identify the mechanisms that promote neuronal differentiation to achieve neuronal diversity in the human brain. Here, we demonstrate the derivation of corticofugal neurons from a genetically engineered Fezf2-YFP hESC reporter line, and uncover two distinct Fezf2 subpopulations that are reminiscent of the 2 Fezf2-expressing neuronal subtypes in the developing mouse brain. Fezf2 is a transcription factor that is both necessary and sufficient for the specification of subcerebral projection neurons in mouse. Its role in human corticogenesis is still unknown. However, the high conservation of FEZF2 protein between mouse and human suggest that Fezf2 is a specific marker of human cerebral neurons as well. Two hypotheses drove our research: 1) Extrinsic factors that modulate in vivo developmental signaling pathways play a critical role in the differentiation of hESCs to a corticofugal fate in vitro; 2) Human embryonic stem cell-derived neurons can survive in vivo and extend axonal projections to specific targets in the rodent brain. Our research shows that hESCs-derived corticofugal neurons are an effective model system to investigate the molecular pathways that regulate human cortical differentiation, axon extension and survival, an endeavor that was until now proscribed due to the manipulation of human embryos.
Subjects/Keywords: Biology; Neurosciences; Fezf2; hESCs; neuron
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APA ·
Chicago ·
MLA ·
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Export
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APA (6th Edition):
Kmet, M. M. (2013). Differentiation of human embryonic stem cells into Corticofugal projection neurons. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1jp080qr
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kmet, Muriel Marie. “Differentiation of human embryonic stem cells into Corticofugal projection neurons.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1jp080qr.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kmet, Muriel Marie. “Differentiation of human embryonic stem cells into Corticofugal projection neurons.” 2013. Web. 01 Mar 2021.
Vancouver:
Kmet MM. Differentiation of human embryonic stem cells into Corticofugal projection neurons. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1jp080qr.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kmet MM. Differentiation of human embryonic stem cells into Corticofugal projection neurons. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/1jp080qr
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
13.
Hefty, Adam Dylan.
Labor and Lamentation: A Genealogy of Acedia, Alienated Labor, and Depressed Affects.
Degree: History of Consciousness (Philosophy), 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/2f55g7fc
► The increasing importance of symbolic and emotional forms of labor in capitalism and the democratic profusion of mood disorders such as depression are major dynamics…
(more)
▼ The increasing importance of symbolic and emotional forms of labor in capitalism and the democratic profusion of mood disorders such as depression are major dynamics of the social life of late modernity in the US. These elements of human life are treated as separate in our received, cultural categories, but experientially they seem to converge. Using methods of Foucauldian genealogy and critical theory, I excavate the history of this relationship and theorize its contemporary dynamics. The genealogy starts with medieval acedia, a condition in which inability to work and depressed affects appear as a single problem. Acedia is a partial predecessor of modern conditions such as sloth, ennui, and melancholia, the divisions of which trace affective and social divisions emerging over the course of industrial, capitalist modernity. Late modern capitalism generates types of work and work processes which I characterize as subjective labor, forms of work which require symbolic and affective aspects of workers' subjectivities and intersubjective relationships. Management of workers' moods and initiative becomes central to late capitalism. Late modernity articulates mental normalcy as a positive optimization of mood rather than eradicating abnormalities and a range of techniques of self care emerge, including anti-depressants, short-term psychotherapy, and alternative techniques such as meditation, mindfulness, and stress reduction. Both on the job and in "private" life, mood appears as a problem to be managed. Public discourses of depression are anachronistic at best if they treat work as a secondary question. At a philosophical level, this genealogy implies a need to historicize the concept of alienation. Marxian alienation is premised on the production of physical goods in an industrial labor process. Industrial production and managerial techniques are still central to capitalism as a whole, but in advanced capitalist countries, subjective labor becomes politically and arguably economically much more central. Alienation in an economy dominated by subjective labor can be less about a separation between the worker and the product and activity of labor and more about dissociation within the worker's subjectivity. This renders late modern alienation as a problem which is irreducibly psychological and tied up with other dimensions of affective life.
Subjects/Keywords: Philosophy; American studies; History; Acedia; Alienation; Depression; Genealogy; Labor; Laziness
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APA ·
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Export
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Manager
APA (6th Edition):
Hefty, A. D. (2013). Labor and Lamentation: A Genealogy of Acedia, Alienated Labor, and Depressed Affects. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/2f55g7fc
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hefty, Adam Dylan. “Labor and Lamentation: A Genealogy of Acedia, Alienated Labor, and Depressed Affects.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/2f55g7fc.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hefty, Adam Dylan. “Labor and Lamentation: A Genealogy of Acedia, Alienated Labor, and Depressed Affects.” 2013. Web. 01 Mar 2021.
Vancouver:
Hefty AD. Labor and Lamentation: A Genealogy of Acedia, Alienated Labor, and Depressed Affects. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/2f55g7fc.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hefty AD. Labor and Lamentation: A Genealogy of Acedia, Alienated Labor, and Depressed Affects. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/2f55g7fc
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
14.
Eshete, Getachew Tadesse.
Biodiversity And Livelihoods In Southwestern Ethiopia: Forest Loss And Prospects For Conservation In Shade Coffee Agroecosystems.
Degree: Environmental Studies, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/2pc6t277
► The Ethiopian southwest is a global origin for Arabica coffee which is the second most traded global commodity after petroleum; and the most important agricultural…
(more)
▼ The Ethiopian southwest is a global origin for Arabica coffee which is the second most traded global commodity after petroleum; and the most important agricultural commodity for Ethiopia. The region is also a global center of crop domestication and diversification with ancient and diverse social and agricultural systems, languages, and cultural groups. People have been here possibly longer than anywhere on Earth and have longer history of interactions with their natural environment, so they rely principally on these agro-ecosystems for a range of goods and services. The forest remnants represent some of the last remnants for the nation and the world's only habitat that retain diverse wild Arabica coffee populations. However, deforestation and land-use changes have been key drivers of degradation of biodiversity and ecosystem services in the region as in many tropical regions. But, the extent, patterns and drivers of deforestation at local scales in the context of broader socio-ecological dynamics remain poorly understood, although such studies are important for biodiversity conservation and sustainable use of forest resources. I explored land-use changes and forest loss in southwest Ethiopia over the last 40 years (Chapter 1), and the prospects for conserving biological diversity (Chapter 2) and ecosystem services (Chapter 3) in coffee landscapes. Over 40 years, more than 50% of the forest cover has been lost or converted to small-scale and large-scale coffee, Eucalyptus and tea plantations as well as other annual croplands. Deforestation rates varied in space and time as a function of the complex and interacting effects of local socio-cultural processes, and external policy and demographic pressures that influenced socio-ecological feedbacks locally. To understand the effects of deforestation and fragmentation on biodiversity, I examined patterns of woody plant diversity in the remaining forests, and studied the potential and limitations of conserving native biodiversity in coffee agroforests. There are four types of shade coffee production systems (wild, semi-wild, small-scale garden and plantation coffee) in the region. The wild and semi-wild (small-scale) shade coffee systems retain more native woody biodiversity than large-scale coffee plantations. Although over 60% of woody species and associated biodiversity can be conserved in these shade coffee systems depending on management and the species, some species such as understory shrubs and herbs, slow-growing large trees and lianas cannot persist. While traditionally diverse coffee agroforests can retain some components of native biodiversity, these agroforests are also facing intensification and conversion to working landscapes that support less biodiversity. In order to reduce deforestation and intensification and conserve biodiversity in these forests and coffee agroforests, it is essential to promote local ecosystem benefits to millions of people living in these ecosystems. I used socio-ecological and market surveys to assess the local benefits of…
Subjects/Keywords: Ecology; Environmental studies; Conservation biology; biodiversity conservation; coffee agroforests; deforestation; eco-agriculture; ecosystem services; land-use changes
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APA ·
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MLA ·
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APA (6th Edition):
Eshete, G. T. (2013). Biodiversity And Livelihoods In Southwestern Ethiopia: Forest Loss And Prospects For Conservation In Shade Coffee Agroecosystems. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/2pc6t277
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Eshete, Getachew Tadesse. “Biodiversity And Livelihoods In Southwestern Ethiopia: Forest Loss And Prospects For Conservation In Shade Coffee Agroecosystems.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/2pc6t277.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Eshete, Getachew Tadesse. “Biodiversity And Livelihoods In Southwestern Ethiopia: Forest Loss And Prospects For Conservation In Shade Coffee Agroecosystems.” 2013. Web. 01 Mar 2021.
Vancouver:
Eshete GT. Biodiversity And Livelihoods In Southwestern Ethiopia: Forest Loss And Prospects For Conservation In Shade Coffee Agroecosystems. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/2pc6t277.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Eshete GT. Biodiversity And Livelihoods In Southwestern Ethiopia: Forest Loss And Prospects For Conservation In Shade Coffee Agroecosystems. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/2pc6t277
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
15.
Navarro, Gabriel.
Application of Marine Natural Products: Global Health Drug Discovery, Lead Optimization, Assay Development, and Identification of Latent HIV Reactivating Agents.
Degree: Chemistry, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/2q31p5tg
► Natural products have a longstanding history as clinical therapeutics, making them a valuable source of biomedically-relevant research tools. This dissertation describes the application of natural…
(more)
▼ Natural products have a longstanding history as clinical therapeutics, making them a valuable source of biomedically-relevant research tools. This dissertation describes the application of natural products as tools for drug discovery. By covering four different research projects, this thesis will cover a renovated approach to the classical utilization of marine natural products as screening compounds for primary hit identification, and semi-synthesis for lead development. Chapter 1 gives an overview of the current success and future challenges of natural products, with emphasis on marine-derived natural products. This chapter also includes a set of current literature examples that focus on identifying natural products with target selectivity in mind. The second chapter discusses the application of marine natural products in the discovery of antimalarials. This chapter includes the discovery and structure elucidation of the salinipostin A, a novel antimalarial chemotype with a bicyclic phosphotriester. The chapter ends with the secondary assays that were attempted to identify the mechanism of action of salinipostin A. The third chapter describes the development of the endoperoxide merulin A for the treatment of human African trypanosomiasis. The chapter closes with site localization studies of a merulin A-derived fluorophore in order to give insight into the mechanism of action of endoperoxides against T. brucei. Chapter 4 reports the development of a modular high-content high-throughput P. aeruginosa biofilm inhibition/dispersion screen. Assay development includes the assessment of the innate antibiotic tolerance from preformed biofilms. The results from a large scale screening campaign of a marine natural product library yield the identification of a new biofilm inhibitor skyllamycin B. The chapter ends with the evaluation of skyllamycin B and azithromycin as a co-dosing agent to eradicate preformed biofilms. The final chapter concentrates on the identification of abyssomicin II as a latent HIV reactivating agent. This is the first example of a bacterially-derived natural product to possess latent HIV reactivating activity. While potency excludes abyssomicin II from being a lead compound, mechanistic studies reveal that abyssomicin II reactivates latent HIV through protein kinase C and histone de-acetylase independent manner. These data suggest that the mechanism of latent HIV reactivation is novel.
Subjects/Keywords: Chemistry; Assay development; Global health; Human African trypanosomiasis; Latent HIV; Malaria; Natural products
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APA (6th Edition):
Navarro, G. (2013). Application of Marine Natural Products: Global Health Drug Discovery, Lead Optimization, Assay Development, and Identification of Latent HIV Reactivating Agents. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/2q31p5tg
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Navarro, Gabriel. “Application of Marine Natural Products: Global Health Drug Discovery, Lead Optimization, Assay Development, and Identification of Latent HIV Reactivating Agents.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/2q31p5tg.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Navarro, Gabriel. “Application of Marine Natural Products: Global Health Drug Discovery, Lead Optimization, Assay Development, and Identification of Latent HIV Reactivating Agents.” 2013. Web. 01 Mar 2021.
Vancouver:
Navarro G. Application of Marine Natural Products: Global Health Drug Discovery, Lead Optimization, Assay Development, and Identification of Latent HIV Reactivating Agents. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/2q31p5tg.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Navarro G. Application of Marine Natural Products: Global Health Drug Discovery, Lead Optimization, Assay Development, and Identification of Latent HIV Reactivating Agents. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/2q31p5tg
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
16.
Rosenzweig, Laura.
Hollywood's Spies: Jewish Infiltration of Nazi and Pro-Nazi Groups in Los Angeles, 1933-1941.
Degree: History, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/2sm4c6gn
► Hollywood's Spies: Jewish Infiltration of Nazi and Pro-Nazi Groups in Los Angeles, 1933-1941 by Laura RosenzweigIn the 1930s, Los Angeles was a hotbed of Nazi-influenced…
(more)
▼ Hollywood's Spies: Jewish Infiltration of Nazi and Pro-Nazi Groups in Los Angeles, 1933-1941 by Laura RosenzweigIn the 1930s, Los Angeles was a hotbed of Nazi-influenced political activity. Between 1933-1941, hundreds of far right-wing political groups led by the local chapter of the German-American Bund, emerged in the city. Intent on launching a Nazi-style political movement, these groups fomented a hostile political climate that threatened the city's Jews. In response to the threat, the Jewish executives of the motion picture industry joined with other Jewish leaders in the city to form the Los Angeles Jewish Community Committee (LAJCC.) Publicly, the LAJCC combatted prejudice and religious intolerance by joining in civic group coalitions. Privately, however, the LAJCC paid private investigators to infiltrate these Nazi-influenced groups to monitor their political activities. The information collected by Hollywood's spies was passed onto local, federal and military officials during the decade, informing both the McCormack-Dickstein Committee investigation of Nazi propaganda activity in 1934, and the Dies Committee investigation on un-American activity between 1938-1940. The role that American Jews played in these congressional investigations, let alone the Jews of Hollywood, was not understood by the public at the time, nor by historians since. Drawing on archival collections in Los Angeles, New York, Cincinnati and Washington, this dissertation recovers the story of the LAJCC and Hollywood's spies to revise the consensus on American Jewish political agency and influence in the 1930s. It demonstrates that American Jews were not quite as paralyzed by antisemitism in the 1930s as the consensus contends. The political relationships the LAJCC established and the defense strategies it adopted to combat domestic Nazism reveal a new dimension of American Jewish political influence in the United States in the 1930s. This dissertation also marks the emergence of Los Angeles as a new site of American Jewish political power. As a result of the financial and political backing of the Jews of Hollywood, the LAJCC distinguished itself from other American Jewish defense organizations of the era, rising to political influence in Washington at a time when Jewish leaders in New York and Chicago faltered in the fight against domestic Nazism in the United States.
Subjects/Keywords: History; Judaic studies; Anti-semitism; Hollywood; Jews; Los Angeles; Nazis; Spies
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Rosenzweig, L. (2013). Hollywood's Spies: Jewish Infiltration of Nazi and Pro-Nazi Groups in Los Angeles, 1933-1941. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/2sm4c6gn
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rosenzweig, Laura. “Hollywood's Spies: Jewish Infiltration of Nazi and Pro-Nazi Groups in Los Angeles, 1933-1941.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/2sm4c6gn.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rosenzweig, Laura. “Hollywood's Spies: Jewish Infiltration of Nazi and Pro-Nazi Groups in Los Angeles, 1933-1941.” 2013. Web. 01 Mar 2021.
Vancouver:
Rosenzweig L. Hollywood's Spies: Jewish Infiltration of Nazi and Pro-Nazi Groups in Los Angeles, 1933-1941. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/2sm4c6gn.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rosenzweig L. Hollywood's Spies: Jewish Infiltration of Nazi and Pro-Nazi Groups in Los Angeles, 1933-1941. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/2sm4c6gn
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
17.
Butera, Jeffrey Thomas.
OpenRAM: An Open-Source Memory Compiler.
Degree: Computer Engineering, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/2vv5q88z
► In academia, many Application Specific Integrated Circuits and System-on-Chip design methodologies are limited by the availability of memories. As process technologies shrink, the size and…
(more)
▼ In academia, many Application Specific Integrated Circuits and System-on-Chip design methodologies are limited by the availability of memories. As process technologies shrink, the size and number of memories on a chip are constantly increasing and memory designs become a more significant part of the overall system performance, efficiency, and cost. Random-Access Memories can be time consuming and tedious to custom design, and there are not many options for automating this process. Process design kits from foundries and vendors do not include memory compilers and commercial solutions require expensive licenses and are often un-modifiable and process specific. This thesis introduces OpenRAM, an open-source memory compiler and characterization methodology. The main objective of the OpenRAM compiler is to promote memory research in academia by providing a flexible and portable platform for generating and verifying memory designs across different technologies. Currently, the compiler generates GDSII layout and Spice netlists for single-port SRAM's using the FreePDK 45nm process design kit, and provides timing/power characterization through Spice simulation. Verification of OpenRAM designs in both 130nm (IBM 8RF) and 180nm (IBM 7SF) technologies are in progress.
Subjects/Keywords: Computer engineering; characterization; compiler; GDSII; memory; spice; SRAM
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APA (6th Edition):
Butera, J. T. (2013). OpenRAM: An Open-Source Memory Compiler. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/2vv5q88z
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Butera, Jeffrey Thomas. “OpenRAM: An Open-Source Memory Compiler.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/2vv5q88z.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Butera, Jeffrey Thomas. “OpenRAM: An Open-Source Memory Compiler.” 2013. Web. 01 Mar 2021.
Vancouver:
Butera JT. OpenRAM: An Open-Source Memory Compiler. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/2vv5q88z.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Butera JT. OpenRAM: An Open-Source Memory Compiler. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/2vv5q88z
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
18.
Stanley, Eric A.
Queer Remains: Insurgent Feelings and the Aesthetics of Violence.
Degree: History of Consciousness (Feminist Studies), 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/3129q3r6
► Through an archive of court cases, prison interviews, morgue reports, film, and video, I argue that the promise of liberal democracy and the larger projects…
(more)
▼ Through an archive of court cases, prison interviews, morgue reports, film, and video, I argue that the promise of liberal democracy and the larger projects of humanism are built through the slaughter of other types of (non)sociality. Specifically, I attend to the murders of trans and queer people of color, histories of racialized violence, prisons, HIV/AIDS, and the animal industrial complex to knot together spaces of friction where non-mimetic histories might tell us something about one another. In other words, my project is not about substituting abject bodies, but shows how mechanisms of destruction are used and reused in the multiple projects of epistemic violence. To this end, I am interested in the ontological limits for those named as objects, under relentless force. Utilizing theories of the postcolonial, work in Black studies, feminist science studies, political and bioeconomies, and psychoanalysis, I argue that queer life is necessarily produced as the underside of gender normative, able bodied, white heterosexuality. Queer Remains is about the material remains of trans and queer people, the flesh and bones of those that once were, and also indexes the ways past violations haunt the present. The introduction, "The Afterlives of Social Death" opens with a reading of a closed circuit TV scene of Duanna Johnson, a black trans woman who was brutally beaten by Mississippi police while in custody in 2009. Here I situate my work, and its interventions, in various genealogies of Black, Queer, and Trans studies. The first chapter, "Queer Crypts: Overkill and Ontological Capture," thinks through an archive I assembled of murdered trans and queer people. I work through the gruesome horror of these murders to try to piece together a reading of violence that resists the "bad apple" model that popular LGBT politics argues. The true terror is not only in the pageantry of the murders, but the reality that they are not "outlaw practices," rather they constitute the norm of dominant culture. My second chapter, "Necrocapital: AIDS/Affective Accumulation/Viral Labor," argues that even within the biopolitical state, the reproduction of death is also a space of capitalist accumulation. The violence I highlight is the reality that the HIV cell lines are the alienated cell labor of a person living with HIV, and this labor produces drugs that the same laborer might not be able to afford. My third chapter, "Forced Life: Animality, Trans Captivity and Abolitionist Time," is an extended meditation on forms of "living" that might signify a space of (non)being more unthinkable than death. This chapter's materiality is the dual histories of the prison industrial complex and factory animal farming. Here I am interested in resituating abolition as a way of dislodging the work of humanism as the barometer of liberation. My conclusion, "Death Drops," offers a reading of a 14-year old gay youth's suicide letter, written before he hanged himself in 2010. While such acts are read to be pathological, Seth Walsh suggests in his note that he…
Subjects/Keywords: GLBT studies; Ethnic studies; queer; transgender
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APA ·
Chicago ·
MLA ·
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APA (6th Edition):
Stanley, E. A. (2013). Queer Remains: Insurgent Feelings and the Aesthetics of Violence. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/3129q3r6
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stanley, Eric A. “Queer Remains: Insurgent Feelings and the Aesthetics of Violence.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/3129q3r6.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stanley, Eric A. “Queer Remains: Insurgent Feelings and the Aesthetics of Violence.” 2013. Web. 01 Mar 2021.
Vancouver:
Stanley EA. Queer Remains: Insurgent Feelings and the Aesthetics of Violence. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/3129q3r6.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stanley EA. Queer Remains: Insurgent Feelings and the Aesthetics of Violence. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/3129q3r6
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
19.
Hoobler, Eric Kerstan.
Structural and Therapeutic Investigations of Human Lipoxygenase.
Degree: Chemistry, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/34p7m3mg
► The research in this dissertation describes the investigations of potential therapeutics as well as structural and allosteric properties of human lipoxygenases. Lipoxygenases (LOX) are a…
(more)
▼ The research in this dissertation describes the investigations of potential therapeutics as well as structural and allosteric properties of human lipoxygenases. Lipoxygenases (LOX) are a ubiquitous enzyme found in plants and mammals, of which are responsible for regulation of inflammation in humans. Uncontrolled inflammation in humans may result in various types of cancers and inflammatory diseases, for which LOX is implicated. This has prompted the Holman lab to explore a diverse range on potential therapeutic targets in hopes of discovery of novel selective LOX inhibitors, while concurrently investigating the structural and kinetic properties of the enzyme.Through use of conventional kinetic and structural studies we investigated the role of the polycystin-1 lipoxygenase alpha-toxin (PLAT) domain's role in enzyme catalysis and allosteric regulation. Previous studies had implicated the PLAT domain as being a critical aspect of the allosteric binding site. This theory was explored through extensive investigations into the resulting effects elicited by removal of the PLAT domain from human epithelial 15-lipoxygenase-2 (15-LOX-2). In chapter 2 we present our findings supporting our previous concept, that indeed the PLAT domain plays a key role in the allosteric properties of 15-LOX-2.Chapter 3 describes collaboration with the National Institutes Chemical Genomic Center, where we report the discovery of a novel dual inhibitor targeting fungal sterol 14á-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core. The phenylenediamine core was then translated into the structure of ketoconazole, a highly effective anti-fungal medication for seborrheic dermatitis, to generate a novel compound, ketaminazole. Ketaminazole was found to be a potent dual selective inhibitor against human 5-LOX and CYP51 in vitro.Understanding the mode of action of lipoxygenase (LOX) inhibitors is critical to determining their efficacy in the cell. The pseudoperoxidase assay is an important tool for establishing if an inhibitor is reductive in nature. In chapter 4, we evaluate the effectiveness of two distinct pseudoperoxidase methods in characterizing known inhibitor's redox properties; the "234 nm" decomposition and xylenol orange assay. In addition, we identified rapid inactivation occurring with particular inhibitors in the pseudoperoxidase assay. To account for the resulting inaccuracy attributed to this inhibitor dependent inactivation, we modified the pre-existing "234 nm" assay allowing for observation of this inactivation.
Subjects/Keywords: Biochemistry; allosteric; enzyme; inhibitor; lipoxygenase; pseudoperoxidase; reductive
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Hoobler, E. K. (2013). Structural and Therapeutic Investigations of Human Lipoxygenase. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/34p7m3mg
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hoobler, Eric Kerstan. “Structural and Therapeutic Investigations of Human Lipoxygenase.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/34p7m3mg.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hoobler, Eric Kerstan. “Structural and Therapeutic Investigations of Human Lipoxygenase.” 2013. Web. 01 Mar 2021.
Vancouver:
Hoobler EK. Structural and Therapeutic Investigations of Human Lipoxygenase. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/34p7m3mg.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hoobler EK. Structural and Therapeutic Investigations of Human Lipoxygenase. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/34p7m3mg
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
20.
Ford, Heather.
Evolution Of Tropical Pacific Ocean Dynamics: Surface To Subsurface Temperature Variability From The Pliocene To Present.
Degree: Ocean Sciences, 2013, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/36g8p7gx
► The tropical Pacific is a significant component of the ocean's climate system and a source of considerable global climate variability, including El Niño. Tightly coupled…
(more)
▼ The tropical Pacific is a significant component of the ocean's climate system and a source of considerable global climate variability, including El Niño. Tightly coupled sea surface and thermocline dynamics influence tropical climate on a variety of spatial and temporal scales. Records of past climate surface and subsurface temperature variability, on long and short times scales, may aid in identifying the radiative and dynamic forcing important to tropical climate during different global climate states. During the Pliocene warm period (3.0-4.3 Ma) and Last Glacial Maximum (LGM, ~0.020 Ma) the global mean state was substantially different and may have influenced the behavior and strength of various processes and mechanisms that determine tropical climate. In this dissertation, I use geochemical techniques, including the novel application of the magnesium-calcite ratio of individual planktonic foraminifera, to investigate the different processes that determine tropical change on different time scales and background climate states.In the first project, I generated stable isotope and minor element records using a subsurface dwelling planktonic foraminifera from a transect of sites across the Pacific cold tongue. Using subsurface temperatures as a proxy for thermocline depth, my records suggest there was a gradual shoaling of the eastern equatorial Pacific thermocline from the early Pliocene to present day. In the second and third projects, I use the minor element ratio of individual surface and subsurface dwelling foraminifera to monitor the SST and subsurface temperature background state, high-resolution variability and radiative and dynamic processes that determine tropical climate. The results suggest the tropical western Pacific has responded primarily to radiative forcing on glacial-interglacial time scales since the early Pliocene. In contrast, the eastern Pacific has responded to changes in dynamic and radiative forcing during the last glacial period, which influenced the background spatial pattern of the cold tongue region. Additionally, changes in individual foraminifera variability suggest a decrease in El Niño Southern Oscillation during the most recent glacial period in comparison to the Holocene. These records show that different scales of variability (i.e. long-term, glacial-interglacial, and seasonal/interannual) may illuminate the processes and mechanisms important to paleoclimate interpretations on various temporal and spatial scales.
Subjects/Keywords: Paleoclimate science; Geochemistry; foraminifera; geochemistry; SST; subsurface temperature
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APA ·
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Export
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APA (6th Edition):
Ford, H. (2013). Evolution Of Tropical Pacific Ocean Dynamics: Surface To Subsurface Temperature Variability From The Pliocene To Present. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/36g8p7gx
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ford, Heather. “Evolution Of Tropical Pacific Ocean Dynamics: Surface To Subsurface Temperature Variability From The Pliocene To Present.” 2013. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/36g8p7gx.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ford, Heather. “Evolution Of Tropical Pacific Ocean Dynamics: Surface To Subsurface Temperature Variability From The Pliocene To Present.” 2013. Web. 01 Mar 2021.
Vancouver:
Ford H. Evolution Of Tropical Pacific Ocean Dynamics: Surface To Subsurface Temperature Variability From The Pliocene To Present. [Internet] [Thesis]. University of California – Santa Cruz; 2013. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/36g8p7gx.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ford H. Evolution Of Tropical Pacific Ocean Dynamics: Surface To Subsurface Temperature Variability From The Pliocene To Present. [Thesis]. University of California – Santa Cruz; 2013. Available from: http://www.escholarship.org/uc/item/36g8p7gx
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
21.
Howard, Jonathan Michael.
Investigation Of In Vivo RNA-Protein Interactions Using Individual Nucleotide Resolution Cross-Linking Immunoprecipitation (ICLIP).
Degree: Molecular Cell and Developmental Biology, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1483v1tz
► Eukaryotic gene expression involves a complex system of checkpoints that regulate RNA biogenesis, maturation, and localization. Along the way, these RNA will encounter a host…
(more)
▼ Eukaryotic gene expression involves a complex system of checkpoints that regulate RNA biogenesis, maturation, and localization. Along the way, these RNA will encounter a host of trans-acting factors, collectively known as RNA binding proteins (RBPs), which will govern the fate of RNA at each stage of gene expression. These RNA-protein interactions are the principal regulators of post-transcriptional control and are critical to the accurate expression of human genes. Misregulation of these interactions has been seen to be highly associated with several neurological disorders, cancer and inflammatory diseases. However, the regulatory mechanisms by which RBP function in the context of their RNA associations remains less understood. For my dissertation, I studied the RNA-protein interactions of a small set of proteins involved in the global regulation of transcription, processing and stability of the cellular transcriptome.In order to interrogate the global RNA interactions of the proteins of interest, I performed a technique called individual nucleotide resolution crosslinking immunoprecipitation, or iCLIP. This technique takes advantage of photoreactive amino acids and nucleic acids in order to capture the in situ RNA-protein interactions of endogenous factors from both cell culture and tissue samples. Partial RNase digestion, stringent purification conditions, and advantageous use of reverse transcriptase difficulty reading through protein adducts allow for direct identification both the genomic origin of the CLIP RNA and the exact crosslinking site of the RNA-binding protein of interest at high specificity. These data form a functional RNA-protein interaction map to elucidate putative molecular roles for any RBP. I have used this technique on three separate projects in order to elucidate the mechanisms by which these RNA binding proteins regulate their targets and interact and modulate the binding of other RNA-binding proteins. First, I studied the effects of modulating the cellular levels of a splicing repressor, hnRNP A1, on the RNA recognition and binding of two splicing enhancer, U2AF65 and SRSF1, and the subsequent changes in pre-mRNA splicing. Secondly, in two concurrent collaborations, I elucidated the endogenous RNA binding targets of IGF2BP3, an oncofetal RBP whose up-regulation is associated with aggressive pancreatic cancer and B-cell leukemia. Finally, I elucidated the effects of human disease-associated genetic mutations on RNA-protein interactions in the context of pre-mRNA splicing. These studies are discussed herein.
Subjects/Keywords: Molecular biology; iCLIP; Pre-mRNA splicing; RNA binding proteins; RNA Biology; RNA-Protein interactions; Transcriptomics
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APA ·
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MLA ·
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Export
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APA (6th Edition):
Howard, J. M. (2015). Investigation Of In Vivo RNA-Protein Interactions Using Individual Nucleotide Resolution Cross-Linking Immunoprecipitation (ICLIP). (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1483v1tz
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Howard, Jonathan Michael. “Investigation Of In Vivo RNA-Protein Interactions Using Individual Nucleotide Resolution Cross-Linking Immunoprecipitation (ICLIP).” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1483v1tz.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Howard, Jonathan Michael. “Investigation Of In Vivo RNA-Protein Interactions Using Individual Nucleotide Resolution Cross-Linking Immunoprecipitation (ICLIP).” 2015. Web. 01 Mar 2021.
Vancouver:
Howard JM. Investigation Of In Vivo RNA-Protein Interactions Using Individual Nucleotide Resolution Cross-Linking Immunoprecipitation (ICLIP). [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1483v1tz.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Howard JM. Investigation Of In Vivo RNA-Protein Interactions Using Individual Nucleotide Resolution Cross-Linking Immunoprecipitation (ICLIP). [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/1483v1tz
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
22.
Crook, Elizabeth Derse.
Corals and Ocean Acidification: Insights on Reef Community Development and Coral Calcification in an Acidified Ocean.
Degree: Earth Science, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/14f305xb
► As the surface ocean equilibrates with rising atmospheric pCO2, the pH of surface seawater is decreasing with potentially negative impacts to coral calcification and coral…
(more)
▼ As the surface ocean equilibrates with rising atmospheric pCO2, the pH of surface seawater is decreasing with potentially negative impacts to coral calcification and coral reef ecosystems. This dissertation is composed of 4 individual studies that explore the impacts of ocean acidification on community reef development, coral calcification rates, and the acclimatization potential of corals to decreasing seawater pH. This is accomplished through in-situ field investigations on a tropical coral reef and laboratory experiments on temperate solitary corals.In Chapters II-IV, I present findings from field investigations at Puerto Morelos, Mexico concerning the impact of in-situ declines in saturation state (Ωarag) on a reef community. Chapter II is a survey of the impact of saturation state on coral species richness, abundance, and colony size. I observe that while corals are often found in under-saturated waters, species richness, number of individuals, and colony size all decrease with decreasing saturation state. The study concludes that impacts of ocean acidification vary widely by species and geographic distribution, but that overall coral coverage will decline significantly in the 21st century.Chapter III explores the calcification rates of Porites astreoides corals in low and under-saturated waters and compares them to rates of colonies growing in control zones approximately 10m away. I conclude that decreases in saturation state are associated with significant declines in coral calcification, driven mainly by decreasing density of the skeletal material. Additionally, decreasing saturation state was associated with significant increases in the rate of bioerosion by boring organisms. In Chapter IV, I address how ocean acidification may impact a reef ecosystem through a year-long recruitment experiment. I deploy limestone tiles in both low saturation and control zones and recover them at 3, 6, and 14 month intervals. Tiles in low saturation zones have up to 70% less coverage of calcifying organisms, coincident with an increase in fleshy algal coverage. Crustose and upright coralline algae are up to 90% less abundant on low saturation tiles after 14 months, despite their ability to establish on the tiles. These findings indicate that calcifying organisms, while physiologically tolerant of low saturation, are outcompeted by fleshy algae under ocean acidification conditions. In Chapter V, I explore laboratory experiments on a temperate scleractinian coral, Balanophyllia elegans, to address how decreasing pH and level of nutrition impact coral calcification. In these experiments, I manipulate pCO2 (410, 770, and 1220 μatm) and feeding frequency (3 days vs. 21 days) in a closed seawater system to address the energetic requirements of calcification in corals without the aid of the symbiotic dinoflagellate, zooxanthellae. Planulation rates were affected by food level but not pCO2, while juvenile mortality was highest under high pCO2 (1220 µatm) and low food (21 day intervals). While net calcification was positive even at…
Subjects/Keywords: Biogeochemistry; Calcification; Coral Reefs; Global Change; Ocean Acidification
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APA (6th Edition):
Crook, E. D. (2015). Corals and Ocean Acidification: Insights on Reef Community Development and Coral Calcification in an Acidified Ocean. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/14f305xb
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Crook, Elizabeth Derse. “Corals and Ocean Acidification: Insights on Reef Community Development and Coral Calcification in an Acidified Ocean.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/14f305xb.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Crook, Elizabeth Derse. “Corals and Ocean Acidification: Insights on Reef Community Development and Coral Calcification in an Acidified Ocean.” 2015. Web. 01 Mar 2021.
Vancouver:
Crook ED. Corals and Ocean Acidification: Insights on Reef Community Development and Coral Calcification in an Acidified Ocean. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/14f305xb.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Crook ED. Corals and Ocean Acidification: Insights on Reef Community Development and Coral Calcification in an Acidified Ocean. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/14f305xb
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
23.
Heilman, Brandon James.
Photoactive Nitric Oxide Delivery Systems based on Metal Nitrosyl-Biomaterial Composites.
Degree: Chemistry, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/18b2v1n3
► Gaseous NO has been recognized as a potent antibiotic even against highly drug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) in both animal and human…
(more)
▼ Gaseous NO has been recognized as a potent antibiotic even against highly drug-resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) in both animal and human studies. However, difficulties in the delivery of the toxic (and reactive) gas demands innovative techniques to deliver NO in a controlled manner to malignant sites throughout the body. Metal nitrosyls reported by our group have demonstrated rapid NO release under the complete control of visible and NIR light. Careful incorporation of these photoactive nitrosyls into polymer matrices has afforded a set of nitrosyl-polymer composites in order to localize the NO-donors at a targeted site, ensure reliable NO release kinetics in vivo, and prevent potentially cytotoxic interactions of the metal nitrosyl or its reaction-products with the treatment site. The work presented in this thesis was pursued to derive clinically relevant NO-delivery systems and demonstrate their utility for the treatment of infection.In chapter 2, an NO-releasing polyurethane film (PUX-NO) is described with dispersed xerogel particles containing up to 3 mol% of [Mn(PaPy3)(NO)](ClO4) entrapped in a silica matrix and swelled with excess moisture. The polyurethane based xerogel-nitrosyl (PUX-NO) films demonstrated rapid NO photorelease upon illumination with low-power visible light which was sufficient to eradicate clinically relevant loads (105 CFU mL-1) of several gram-positive and gram-negative pathogenic bacteria, including a strain of methicillin-resistant of S. aureus. The results of this study suggest that PUX-NO films are suitable for use as a NO-releasing occlusive film for the treatment of skin and soft-tissue infections or chronic, non-healing wounds. Since the NO-release rate from the films can be modulated by simple adjustment of the intensity of the light source, the films could be used to first clear the microbial burden from the wound site using high fluxes of NO, and then, provide a moderate, sustained flux of NO in order to accelerate the wound healing process and mitigate the potential for recurrent infections. Chapter 3 details the incorporation of a photoactive Mn nitrosyl in the mesopores of a MCM-41 type silicate to afford {Mn-NO}@MCM-41. To increase the interaction between the nitrosyl and the MCM-41 pore walls, an aluminosilicate-based material (Al-MCM-41) was used with 3 mol% AlIII substituted for tetrahedral SiIV sites, which introduced negative point charges capable of electrostatically binding the cationic nitrosyl. Homegenous loading of the Mn nitrosyl (up to 25 wt.%) throughout the hexagonally packed, uni-dimensional mesopores of the Al-MCM-41 particles was determined using various analytical techniques including ICP-MS, FAAS, PXRD, N2 sorption isometry, UV-vis DRS, FTIR, and SEM-EDX. Exposure of {Mn-NO}@Al-MCM-41 to visible light of similar intensity to sunlight on a bright day (100 mW cm-2) released high fluxes of NO that effectively eradicated a multi-drug resistant strain of Acinetobacter baumannii. In another study, described in Chapter…
Subjects/Keywords: Inorganic chemistry; Materials Science; Biomedical engineering; mesoporous; metal nitrosyls; nitric oxide; NO donors; photochemotherapeutics; polymer matrices
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APA ·
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APA (6th Edition):
Heilman, B. J. (2015). Photoactive Nitric Oxide Delivery Systems based on Metal Nitrosyl-Biomaterial Composites. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/18b2v1n3
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Heilman, Brandon James. “Photoactive Nitric Oxide Delivery Systems based on Metal Nitrosyl-Biomaterial Composites.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/18b2v1n3.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Heilman, Brandon James. “Photoactive Nitric Oxide Delivery Systems based on Metal Nitrosyl-Biomaterial Composites.” 2015. Web. 01 Mar 2021.
Vancouver:
Heilman BJ. Photoactive Nitric Oxide Delivery Systems based on Metal Nitrosyl-Biomaterial Composites. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/18b2v1n3.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Heilman BJ. Photoactive Nitric Oxide Delivery Systems based on Metal Nitrosyl-Biomaterial Composites. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/18b2v1n3
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
24.
Buschmann, Luke Norman.
Virtual Modified Constraint Induced Movement Therapy for Stroke Survivors with Hemiparesis.
Degree: Computer Engineering, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/18n44902
► Modified constraint induced movement therapy is a focus of rehabilitation research for stroke survivors with hemiplegia that relies on physically constraining a patient's unaffected limb…
(more)
▼ Modified constraint induced movement therapy is a focus of rehabilitation research for stroke survivors with hemiplegia that relies on physically constraining a patient's unaffected limb to modify a patient's behavior and force the use of the affected limb in a rehabilitation setting. In this study, we attempt to cognitively induce a constraint in patients engaging in virtual therapy via a Kinect and Unity based platform. The platform included four games that each utilized a different active range of motion (ROM) exercise for control of game objects. Five stroke survivors with hemiparesis were recruited for a two week study consisting of five, 25-minute therapy sessions each. Users were allowed to use either their unaffected or affected limb to play each game at any time and allowed their choice of games during each session. For each game, the difficulty level remained at baseline while the user used their affected side to play but the difficulty was increased at varying rates when the user used their unaffected side to play. Results were evaluated for compliance to the therapy (usage rate of affected side), choice of games, performance, efficacy of therapy (ROM), and qualitative behavior of users.Compliance during virtual mCIT seems to be higher than that of traditional mCIT but a more extensive user test is necessary to validate this result. ROM measurements did not provide a clear trend due to the small size and duration of the data set. Trends were found in several areas of user behavior: (1) users preferred games utilizing only one axis of control and not reliant on orientation of the limb, (2) users also tended to play games in a certain order, (3) user performance increased over time, and (4) users often incorrectly performed the desired active ROM exercise for each game which may indicate the necessity to observe and coach patients during virtual rehabilitation.
Subjects/Keywords: Computer engineering; Physical therapy; Behavioral sciences; cimt; constraint induced movement therapy; hemiplegia; kinect rehab; stroke rehabilitation; virtual rehabilitation
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APA ·
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APA (6th Edition):
Buschmann, L. N. (2015). Virtual Modified Constraint Induced Movement Therapy for Stroke Survivors with Hemiparesis. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/18n44902
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Buschmann, Luke Norman. “Virtual Modified Constraint Induced Movement Therapy for Stroke Survivors with Hemiparesis.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/18n44902.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Buschmann, Luke Norman. “Virtual Modified Constraint Induced Movement Therapy for Stroke Survivors with Hemiparesis.” 2015. Web. 01 Mar 2021.
Vancouver:
Buschmann LN. Virtual Modified Constraint Induced Movement Therapy for Stroke Survivors with Hemiparesis. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/18n44902.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Buschmann LN. Virtual Modified Constraint Induced Movement Therapy for Stroke Survivors with Hemiparesis. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/18n44902
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
25.
Cheng, Andrew.
Systematic analysis of two-component signal transduction systems in Vibrio cholerae biofilm formation and virulence.
Degree: Microbiology and Environmental Toxicology, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1dp6d7nh
► Vibrio cholerae, the causative agent of cholera, is a facultative human pathogen that can inhabit aquatic environments and human intestines. Its survival in aquatic habitats…
(more)
▼ Vibrio cholerae, the causative agent of cholera, is a facultative human pathogen that can inhabit aquatic environments and human intestines. Its survival in aquatic habitats is critical for its transmission to humans. However, how V. cholerae senses and responds to fluctuating environmental factors experienced during aquatic and intestinal growth remains to be explained.One way in which V. cholerae could sense and respond to changes in the environment is through use of a two-component signal transduction systems (TCS). The TCS can regulate a wide variety of behaviors and processes, including virulence, biofilm formation, stress response, and motility. The prototypical TCS consists of a membrane-bound histidine (HK), which senses environmental signals and a corresponding response regulator (RR), which mediates a cellular response. I investigated the role of each TCS in V. cholerae infection and biofilm formation by focusing on RRs, the most downstream component. First, I performed mutational analysis of all (53) RRs. I generated a set of 53 isogenic RR mutants in V. cholerae by deletion analysis. To test whether V. cholerae these RRs are involved in virulence, I screened my library of 53 RR deletion mutants in a murine model of infection. In addition to the 13 previously identified RRs that control virulence, I identified an uncharacterized TCS named VxrB (Vibrio type six regulator) that is required for intestinal colonization. Transcriptome analysis revealed that VxrB activates type VI secretion system (T6SS) genes, which encode a complex molecular machine to inject effector proteins into target cells. Identification of a new TCS controlling virulence is significant because it fills gaps in our knowledge about V. cholerae pathogenesis, contributes to the general understanding of how TCS is regulated and suggests new methods for manipulating pathogenic behavior to improve human health. This could represent a target for developing anti-bacterial strategies. Regulation of biofilm formation in V. cholerae involves several transcriptional regulators and alternative sigma factors, such as RpoN. The exact mechanism by which RpoN impacts biofilm formation is yet to be determined. RpoN functions together with the NtrC family of RR, thus raising the possibility that biofilm formation requires both RpoN and an NtrC family RR. In this study, I analyzed the role of the eight NtrC family RRs in biofilm formation and identified four of these RR’s regulating biofilm formation. LuxO positively regulates biofilm formation. In contrast FlrC, FlrA and NtrC negatively regulate biofilm formation. Consistent with this observation, whole-genome expression profiling and transcriptional reporter assays revealed that expression of the Vibrio polysaccharide (vps) genes and genes encoding the two positive transcriptional regulators, VpsR and VpsT, is increased in an ntrC mutant. Epistasis analysis showed that NtrC acts in parallel with HapR and CRP-cAMP complex, the negative regulators of biofilm formation. This study underscores the importance…
Subjects/Keywords: Microbiology; biofilm; response regulator; Two-component signal trandsuction; Vibrio cholerae; virulence
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APA ·
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APA (6th Edition):
Cheng, A. (2015). Systematic analysis of two-component signal transduction systems in Vibrio cholerae biofilm formation and virulence. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1dp6d7nh
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cheng, Andrew. “Systematic analysis of two-component signal transduction systems in Vibrio cholerae biofilm formation and virulence.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1dp6d7nh.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cheng, Andrew. “Systematic analysis of two-component signal transduction systems in Vibrio cholerae biofilm formation and virulence.” 2015. Web. 01 Mar 2021.
Vancouver:
Cheng A. Systematic analysis of two-component signal transduction systems in Vibrio cholerae biofilm formation and virulence. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1dp6d7nh.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cheng A. Systematic analysis of two-component signal transduction systems in Vibrio cholerae biofilm formation and virulence. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/1dp6d7nh
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
26.
Sampson, Devon D.
Interconnections of Agrobiodiversity and Food Security in Rural Yucatan, Mexico.
Degree: Environmental Studies, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1j46k3cc
► Biodiversity conservation and food security are often assumed to be separate or conflicting issues. In the municipality of Tzucacab, in a rural corner of Mexico’s…
(more)
▼ Biodiversity conservation and food security are often assumed to be separate or conflicting issues. In the municipality of Tzucacab, in a rural corner of Mexico’s Yucatan peninsula, I found that crop diversity and food security are deeply intertwined. I measured food security and home garden agrobiodiversity on a randomized selection of sixty smallholder farms in the municipality, conducted ethnographic interviews over a period of four years, and collaborated with six high school students on a participatory photography project documenting local food culture. From the quantitative data, I found that crop diversity is the strongest predictor of household food security during a drought in the rural municipality I surveyed. This finding indicates that maintaining high levels of agrobiodiversity can be an important strategy for subsistence farmers to buffer their food supply against the risk of crop failure. Additionally, I found evidence that diversification of the home garden is one important strategy managing risk among a complex of several approaches to livelihood diversification. The finding helps to explain why some farmers conserve diversity while others do not, and suggests that the goals of agrobiodiversity conservation and rural food security might be better addressed together. These results point to the ability of small-scale, diverse farms run by campesino farmers to feed themselves, challenging the dominant discourse and practice of development that prioritizes increasing yields above all other properties of agroecosystems.
Subjects/Keywords: Environmental studies; Agriculture; Geography; Agrobiodiversity; Agroecology; Biodiversity; Biodiversity-Ecosystem Functioning; Food Security; Food Sovereignty
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APA (6th Edition):
Sampson, D. D. (2015). Interconnections of Agrobiodiversity and Food Security in Rural Yucatan, Mexico. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1j46k3cc
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sampson, Devon D. “Interconnections of Agrobiodiversity and Food Security in Rural Yucatan, Mexico.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1j46k3cc.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sampson, Devon D. “Interconnections of Agrobiodiversity and Food Security in Rural Yucatan, Mexico.” 2015. Web. 01 Mar 2021.
Vancouver:
Sampson DD. Interconnections of Agrobiodiversity and Food Security in Rural Yucatan, Mexico. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1j46k3cc.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sampson DD. Interconnections of Agrobiodiversity and Food Security in Rural Yucatan, Mexico. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/1j46k3cc
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
27.
Howes, Ellen Elizabeth.
Twenty-Four Power Suits.
Degree: Theater Arts, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1mj00153
► ABSTRACT"Twenty-Four Power Suits" by Ellen HowesThis thesis sets out to illustrate my process as the costume designer for The University of California, Santa Cruz (UCSC)…
(more)
▼ ABSTRACT"Twenty-Four Power Suits" by Ellen HowesThis thesis sets out to illustrate my process as the costume designer for The University of California, Santa Cruz (UCSC) Theater Arts Department’s production of Congressladies, Mary Kay Gamel’s modern adaptation of Aristophanes’ Ecclesiazusae. In collaborating with the director, the designer must create designs that help connect the characters to the world in which the play takes place, as well as reflect the tone of the performance. This thesis will examine the process by which I achieved the actualization of the director's vision as well as explore the analytical layers beneath my designs. Throughout the chronological process, I will focus on the impact that my designs had in the satirizing of important political issues, the clarification of important plot points, and in paralleling Mary Kay Gamel’s modern adaptation to the original Aristophanic text.
Subjects/Keywords: Design; Theater history; Theater; Aristophanes; Assemblywomen; Congress; Costume; Design; Ecclesiazusae
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APA (6th Edition):
Howes, E. E. (2015). Twenty-Four Power Suits. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1mj00153
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Howes, Ellen Elizabeth. “Twenty-Four Power Suits.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1mj00153.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Howes, Ellen Elizabeth. “Twenty-Four Power Suits.” 2015. Web. 01 Mar 2021.
Vancouver:
Howes EE. Twenty-Four Power Suits. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1mj00153.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Howes EE. Twenty-Four Power Suits. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/1mj00153
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
28.
Axarlian, Gabriel Pablo.
Fade In: Exploring The Effects of Technological Change on Consumers and Firm Revenues in Home Entertainment Markets for Film.
Degree: Economics, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1rs635wz
► AbstractFADE IN:EXPLORING THE EFFECTS OF TECHNOLOGICAL CHANGE ON CONSUMERS AND FIRM REVENUES IN HOME ENTERTAINMENT MARKETS FOR FILM Gabriel Axarlian This dissertation is composed of…
(more)
▼ AbstractFADE IN:EXPLORING THE EFFECTS OF TECHNOLOGICAL CHANGE ON CONSUMERS AND FIRM REVENUES IN HOME ENTERTAINMENT MARKETS FOR FILM Gabriel Axarlian This dissertation is composed of three related works, two of which are similar in data and time span with the third being more independent in this respect. The three works focus on the nature of the film industry’s adaptation to changing technologies in home entertainment markets. My analysis studies the effectiveness of new strategies as well as the effect changing technologies has had on market share of various product types. The first work is titled, “The Introduction of Infinite Durability to an Information Good and the Decision to Buy or Rent: Evidence from the Film Industry”. Home entertainment markets have seen dramatic declines in revenues over the last ten years due to the digital revolution, making new adaptation strategies of crucial importance to maintaining existing profitability. Recently, the film industry has worked with related firms to develop a standardized ecosystem for the sale and access to digital versions of their films. This system, known as UltraViolet, embodies infinite durability; the perpetual access to a purchased film across computing platforms and time. I make use of exogenous variation in the implementation of this system to study the effect the introduction of this new feature has had on the decision to buy versus rent. My findings show that the inclusion of infinite durability creates enough value to spur increased purchasing behavior. Also, the inclusion of infinite durability creates a high degree of substitutability amongst products that include it in purchase markets. Lastly, I find evidence that the lack of inclusion of infinite durability will spur consumers to rent rather than buy. The second work is titled, “Early to Sell, Do Revenues Rise? The Effect of the Digital Sell-Through Window on Home Entertainment Markets”. In 2012, several film studios began selling digital versions of their films 1-4 weeks before their release into physical media markets (rental and sell-through). This was an attempt to boost overall waning revenues from home entertainment. I examine the effect this has had on physical media sell-through and rental markets using a nested-logit model approach. The analysis yielded three significant results. One is that the length of the window is inversely related to its effect on the behavior of buying or renting of discs. The second is that this strategy has mainly affected the consumption behavior of disc renters to buy digital. The third result of note is that although the strategy is effective, it is not creating loyal consumers of this new method of distribution. This fact notwithstanding the strategy has increased home entertainment revenues. The third and final work is titled, “The Long Tail Effect in Home Entertainment Rental Markets”. The long tail, theoretically, is the phenomenon that results from the availability of infinite inventory retailers which allow for niche products to have enough…
Subjects/Keywords: Economics; Applied Economics; Discrete Choice Model; Economics; Home Entertainment Industry; Media Economics; Microeconomics
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Manager
APA (6th Edition):
Axarlian, G. P. (2015). Fade In: Exploring The Effects of Technological Change on Consumers and Firm Revenues in Home Entertainment Markets for Film. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1rs635wz
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Axarlian, Gabriel Pablo. “Fade In: Exploring The Effects of Technological Change on Consumers and Firm Revenues in Home Entertainment Markets for Film.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1rs635wz.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Axarlian, Gabriel Pablo. “Fade In: Exploring The Effects of Technological Change on Consumers and Firm Revenues in Home Entertainment Markets for Film.” 2015. Web. 01 Mar 2021.
Vancouver:
Axarlian GP. Fade In: Exploring The Effects of Technological Change on Consumers and Firm Revenues in Home Entertainment Markets for Film. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1rs635wz.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Axarlian GP. Fade In: Exploring The Effects of Technological Change on Consumers and Firm Revenues in Home Entertainment Markets for Film. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/1rs635wz
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
29.
Capelis, D J.
Embedding Security into Systems After Their Design.
Degree: Computer Science, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1vn6v7wg
► Security is rarely designed into systems and architectures from the beginning. Typically, security enters into the design process only after applications are built and security…
(more)
▼ Security is rarely designed into systems and architectures from the beginning. Typically, security enters into the design process only after applications are built and security issues arise. While security is often dependent on specific use cases, decades of development provide an opportunity to synthesize common security needs into a set of critical features and embed them into the core underlying systems.Please don't get this dissertation through ProQuest. Copies are freely available from the UC Santa Cruz library and the University of California's open access eScholarship initiative (see escholarship.org) and my website: capelis.dj
Subjects/Keywords: Computer science
Record Details
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Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
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Manager
APA (6th Edition):
Capelis, D. J. (2015). Embedding Security into Systems After Their Design. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1vn6v7wg
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Capelis, D J. “Embedding Security into Systems After Their Design.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1vn6v7wg.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Capelis, D J. “Embedding Security into Systems After Their Design.” 2015. Web. 01 Mar 2021.
Vancouver:
Capelis DJ. Embedding Security into Systems After Their Design. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1vn6v7wg.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Capelis DJ. Embedding Security into Systems After Their Design. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/1vn6v7wg
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of California – Santa Cruz
30.
Beloi, Aleksander.
Shintani's Method: zeta values and Stark units.
Degree: Mathematics, 2015, University of California – Santa Cruz
URL: http://www.escholarship.org/uc/item/1xq492c2
► We prove a formula relating Dedekind zeta functions associated to a number field k to certain Shintani zeta functions, whose analytic properties and values at…
(more)
▼ We prove a formula relating Dedekind zeta functions associated to a number field k to certain Shintani zeta functions, whose analytic properties and values at non-positive integers have been well studied by Takuro Shintani. This allows us to compute explicit formulas for Dedekind zeta functions, partial zeta functions and certain L-series and their derivatives evaluated at non-positive integers. We relate the explicitly given value of the derivative of partial zeta functions at s=0 to those predicted by abelian Stark's conjecture. Though this conjecture remains open, we are able to write down explicit formulas for the absolute values of the conjectured Stark units.The main ingredient in these formulas is an explicit proof of Shintani's unit theorem for number fields of arbitrary signature. This says that the totally positive units of a number field k has a fundamental domain given by a signed union of polyhedral cones in the Minkowski space of the field. Existence of such domains was known to Shintani. In the case k is a totally real field, Colmez, Diaz y Diaz – Friedman and Charollois-Dasgupta-Greenberg were able to construct such domains and give their generators explicitly. We give an explicit construction of such domains for number fields of arbitrary signature with an exact formula for the domain. Moreover, our construction is cohomological, allowing for future cohomological applications of Shintani's method as in the work of Charollois – Dasgupta – Greenberg.This construction allows us to write Dedekind zeta functions and partial zeta functions in terms of certain analytic zeta functions defined over polyhedral cones (Shintani zeta functions). Thus we are able to translate questions about special values of Dedekind zeta functions to those about special values of Shintani zeta, whose values at non-positive integers are given by closed finite expressions due to work of Shintani.
Subjects/Keywords: Mathematics; Number Theory
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Beloi, A. (2015). Shintani's Method: zeta values and Stark units. (Thesis). University of California – Santa Cruz. Retrieved from http://www.escholarship.org/uc/item/1xq492c2
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Beloi, Aleksander. “Shintani's Method: zeta values and Stark units.” 2015. Thesis, University of California – Santa Cruz. Accessed March 01, 2021.
http://www.escholarship.org/uc/item/1xq492c2.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Beloi, Aleksander. “Shintani's Method: zeta values and Stark units.” 2015. Web. 01 Mar 2021.
Vancouver:
Beloi A. Shintani's Method: zeta values and Stark units. [Internet] [Thesis]. University of California – Santa Cruz; 2015. [cited 2021 Mar 01].
Available from: http://www.escholarship.org/uc/item/1xq492c2.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Beloi A. Shintani's Method: zeta values and Stark units. [Thesis]. University of California – Santa Cruz; 2015. Available from: http://www.escholarship.org/uc/item/1xq492c2
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations