publisher:("Trinity College Dublin")

1. Glynn, Natalie. Negotiating Uncertainity and Earning Respect: A Qualitative, Longitudinal Study of Young People Ageing Out of State Care in Ireland.

Degree: School of Social Work & Social Policy. Discipline of Social Studies, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92277

► This thesis is an exploration of the lived experience of the transition out of care at the age of 18 in Ireland. There is a… (more)

▼ This thesis is an exploration of the lived experience of the transition out of care at the age of 18 in Ireland. There is a plethora of research demonstrating the marginalisation and disadvantage experienced by care leavers internationally. Though Ireland's research base is limited, the hardships that care experienced young people face is considered broadly similar to that seen elsewhere. The point of leaving care has been identified as a potentially critical turning point at which services might moderate later outcomes. However, while there is growing evidence identifying social support and identity development as crucial elements, there remains a gap in our understanding of the care-leaving process from the perspective of young people. Initiated in 2015, this research took place during a time of evolving policy and supports for care leavers in the Irish context. Legislation that was passed in 2015 and enacted in 2017 entitles all young people with a history of at least 12 months in care between the ages of 13 and 18 to an aftercare plan identifying their transition needs and available supports. Concurrently, the Child and Family Agency standardised a national policy on financial support for care leavers and initiated the establishment of Aftercare Steering Committees in each service area. These legislative and policy developments expanding and mandating provisions for care leavers form the contextual backdrop for this study. The study utilised a qualitative longitudinal multi-case study methodology underpinned by a critical social constructionist epistemology. Sixteen care leavers from across Ireland, six young women and 10 young men who had aged out of care within the past year, were recruited for a year-long follow-up study. Data were collected at three points in time using in-depth interviewing techniques and supported by creative documentation during the interim period between meetings. The fieldwork was initiated by a community assessment process in which gatekeepers and other stakeholders were contacted. Recruitment was pursued through these contacts and included a variety of services, such as aftercare service providers, homelessness services, teen pregnancy and addiction services. Utilising liminality theory, Recognition theory and the concept of precarity, the analysis revealed a number of insights into the interplay between structure and agency in the transition out of care. The analysis identified two processes in which the care leavers engaged to manage the transition out of care: striving for a 'normal' life and negotiating uncertainty. 'Normal' life adhered to a traditional image of standard adulthood that developed in the 1950s, including financial stability from employment, homeownership and family formation. Ageing out in a context of welfare retrenchment and youth policy that encourages individuals' reliance on family supports, young people described uncertainty about the future and the meeting of their vital needs, such as housing and food. In the system of rationed supports, care leavers sought… Advisors/Committee Members: Mayock, Paula.

Subjects/Keywords: Ageing Out; Foster Care; Residential Care; State Care; Kinship Care; Recognition Theory; Liminality; Precarity; Social Investment Policy; Care Leavers

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APA (6^th Edition):

Glynn, N. (2020). Negotiating Uncertainity and Earning Respect: A Qualitative, Longitudinal Study of Young People Ageing Out of State Care in Ireland. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92277

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Glynn, Natalie. “Negotiating Uncertainity and Earning Respect: A Qualitative, Longitudinal Study of Young People Ageing Out of State Care in Ireland.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92277.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Glynn, Natalie. “Negotiating Uncertainity and Earning Respect: A Qualitative, Longitudinal Study of Young People Ageing Out of State Care in Ireland.” 2020. Web. 02 Mar 2021.

Vancouver:

Glynn N. Negotiating Uncertainity and Earning Respect: A Qualitative, Longitudinal Study of Young People Ageing Out of State Care in Ireland. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92277.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Glynn N. Negotiating Uncertainity and Earning Respect: A Qualitative, Longitudinal Study of Young People Ageing Out of State Care in Ireland. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92277

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. LUNDAHL, MIMMI LOUISE. The immunomodulatory properties of L-rhamnose.

Degree: School of Biochemistry & Immunology. Discipline of Biochemistry, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92870

► L-Rhamnose is a non-mammalian monosaccharide ubiquitously found on the surface of both commensal and pathogenic bacteria. Previous publications had identified that L-rhamnose-rich Mycobacterium tuberculosis glycolipids,… (more)

Subjects/Keywords: Immunomodulation; Carbohydrates; Macrophages; Tuberculosis; Innate Memory

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APA (6^th Edition):

LUNDAHL, M. L. (2020). The immunomodulatory properties of L-rhamnose. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92870

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

LUNDAHL, MIMMI LOUISE. “The immunomodulatory properties of L-rhamnose.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92870.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

LUNDAHL, MIMMI LOUISE. “The immunomodulatory properties of L-rhamnose.” 2020. Web. 02 Mar 2021.

Vancouver:

LUNDAHL ML. The immunomodulatory properties of L-rhamnose. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92870.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

LUNDAHL ML. The immunomodulatory properties of L-rhamnose. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92870

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. BYRNE, SADHBH. An exploration of caregivers' and peers' support-giving responses to adolescents showing signs of depression.

Degree: School of Psychology. Discipline of Psychology, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92873

► Background: Adolescent depression is linked to significant impairment, recurrence in adulthood, heightened risk of suicide, and increased all-cause mortality (Schubert, Clark, Van, Collinson, & Baune,… (more)

▼ Background: Adolescent depression is linked to significant impairment, recurrence in adulthood, heightened risk of suicide, and increased all-cause mortality (Schubert, Clark, Van, Collinson, & Baune, 2017; Shore, Toumbourou, Lewis, & Kremer, 2018). Compounding the significance and complexity of this issue is the fact that most adolescents experiencing depression do not seek or receive professional help (Sheppard, Deane, & Ciarrochi, 2018; Thornicroft et al., 2017). Multiple strategies have been developed to address this "treatment gap". However, the provision of support from family and friends appears to have been overlooked, with little research existing on this topic despite evidence that this "informal" support may play an important role in determining illness outcomes. Drawing on relevant theories, including the Theory of Planned Behaviour (Ajzen, 1991) and the Attribution-Empathy Model of Helping Behaviour (Betancourt, 1990), the current study aimed to address this gap. The aim of the study was to explore caregivers' and peers' responses to the presentation of symptoms of depression in adolescents. Methods: This cross-sectional study employed a mixed within-between groups design. Participants were 12- to 18-year-old adolescents (n = 535, 47.9% female), and adults who were primary caregivers of adolescent children (n = 321, 73.8% mothers). Data were collected through the use of a questionnaire constructed for the current study, which comprised a selection of instruments measuring each study variable. As no standardised measure of support-giving intentions was identified, the Modes of Intended Mental Health Support (MIMHS) scale was developed, and initial exploratory factor analyses were conducted. Key Results: Caregivers' responses reflect greater mental health literacy than those of adolescents, with adolescents' responses becoming more similar to those of caregivers with increasing age. Sex differences exist in both caregivers' and adolescents' responses' for example, girls and female caregivers feel significantly greater sympathy and less anger towards the adolescent vignette characters. Caregivers and adolescents have very different beliefs about the helpfulness and harmfulness of several support-giving responses, including suicide risk assessment. Young people tend to encourage "insular" support, whereby adult help is not engaged. Some caregivers respond to the presentation of depressive symptoms by attempting to minimise adolescents' problems. The ability to label a cluster of symptoms as "depression" is associated with increased intentions to encourage or facilitate professional support. Discussion: The results of this study thus provide foundational knowledge that can be used to inform future theory and research on this topic. The results also have important implications for guiding efforts to improve the support that caregivers and peers may provide to young people experiencing symptoms of depression. In particular, several factors are highlighted which may be potentially modifiable, and therefore… Advisors/Committee Members: Nixon, Elizabeth.

Subjects/Keywords: adolescent; depression; parent; mental health; peers; youth mental health; help-giving; mental health literacy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

BYRNE, S. (2020). An exploration of caregivers' and peers' support-giving responses to adolescents showing signs of depression. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92873

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BYRNE, SADHBH. “An exploration of caregivers' and peers' support-giving responses to adolescents showing signs of depression.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92873.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BYRNE, SADHBH. “An exploration of caregivers' and peers' support-giving responses to adolescents showing signs of depression.” 2020. Web. 02 Mar 2021.

Vancouver:

BYRNE S. An exploration of caregivers' and peers' support-giving responses to adolescents showing signs of depression. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92873.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BYRNE S. An exploration of caregivers' and peers' support-giving responses to adolescents showing signs of depression. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92873

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. COUGHLAN, PATRICIA. Phylogenetics of paclitaxel biosynthesis genes in Taxus baccata, Taxus hybrids and allies.

Degree: School of Natural Sciences. Discipline of Botany, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92884

► Taxus L. is a genus of trees and shrubs with high value in horticulture,and in medicine as a source of the anticancer drug Paclitaxel. The… (more)

▼ Taxus L. is a genus of trees and shrubs with high value in horticulture,and in medicine as a source of the anticancer drug Paclitaxel. The taxonomy of the group is highly complex due to the lack of diagnostic morphological characters and the high degree of phenotypic plasticity among species. This often leads to misidentification and problems with classification using traditional taxonomic methods that rely solely on morphological characters. The complexity has become an issue for the pharmaceutical industry because of the anti-cancer properties of Paclitaxel. Paclitaxel is a diterpenoid, which is produced by several species of Taxus and is used to treat various forms of cancer. Taxushas a wide global geographic distribution and some taxonomists recognise only a single species with geographically defined subgroups. However, others have preferred to split the genus into several species. To address these differences, we conducted a thorough phylogenetic analysis (Maximum Likelihood, Bayesian Inference and TCS haplotype network analyses) of all its species and many subtaxa using nuclear and plastid gene regions (nrITS and plastid trnL intron and trnL-Fintergenic spacer). Results support the recognition of nine distinct species (T. baccata,T. brevifolia, T. canadensis, T. cuspidata, T. floridana, T. fauna, T. globosa,T. sumatranaand T. wallichiana) but evidence is found for less species distinction and considerable reticulation within the T.baccata, T. canadensis and T. cuspidata group. There is some biogeographic structure in the nrITS data showing that Taxus brevifolia is sister to T. globosa and T. floridana. Taxus fauna groups with T. contorta. Taxus wallichiana is resolved as monophyletic but its varieties T. wallichiana var. mairei, var.chinensis and var.wallichianaare not monophyletic although individuals within varieties generally group well together. Evidence is also presented for the sister group status of Pseudotaxusto Taxusand the inclusion of Amentotaxus, Austrotaxus, Cephalotaxusand Torreyawithin Taxaceae. We compare the results to known taxonomy, and present preliminary new leaf anatomical data using leaf impressions to visualise epidermal and stomatal characters.We also investigate the hybrids T.xmediaand T. xhunnewelliana and present nrITSdata identifying the origin of these taxa and their putative parental species. The biosynthesis of Paclitaxel involves 19 steps. We characterised two genes, Taxadiene synthase (TS) and 10-deacetyl baccatin III-10-0-acetyltranferase (DBAT), involved in the pathway and compared variation in the genes among species of Taxus. TS is involved in the first committed step of the pathway. We developed new molecular PCR primers to amplify and study the TS1 to 5 exon regions. The primary aim was to assess molecular variation in the TSgene at DNA and protein levels and to test for evidence of selection on the gene. However, we also sequenced a section of the DBATgene,for a sample of taxa, to look for evidence of molecular variation in that gene and… Advisors/Committee Members: Hodkinson, Trevor.

Subjects/Keywords: Biogeography; Hybridization; Taxus; nrITS; Paclitaxel; Phylogenetics; Taxaceae; Taxol; trnL-F; Taxadiene synthase

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

COUGHLAN, P. (2020). Phylogenetics of paclitaxel biosynthesis genes in Taxus baccata, Taxus hybrids and allies. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92884

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

COUGHLAN, PATRICIA. “Phylogenetics of paclitaxel biosynthesis genes in Taxus baccata, Taxus hybrids and allies.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92884.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

COUGHLAN, PATRICIA. “Phylogenetics of paclitaxel biosynthesis genes in Taxus baccata, Taxus hybrids and allies.” 2020. Web. 02 Mar 2021.

Vancouver:

COUGHLAN P. Phylogenetics of paclitaxel biosynthesis genes in Taxus baccata, Taxus hybrids and allies. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92884.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

COUGHLAN P. Phylogenetics of paclitaxel biosynthesis genes in Taxus baccata, Taxus hybrids and allies. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92884

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. KENNETH IYOBHEBHE, EHIZEMOYA. The Role of Women in Post Conflict Peace building in Niger Delta.

Degree: School of Religion. Irish School of Ecumenics, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92923

► United Nations Security Council Resolution 1325, passed in October 2000, emphasizes the crucial role of women in the prevention and resolution of conflicts. It urges… (more)

Subjects/Keywords: peacebuilding; women in peace; gender and peace; Niger Delta peace

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APA (6^th Edition):

KENNETH IYOBHEBHE, E. (2020). The Role of Women in Post Conflict Peace building in Niger Delta. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92923

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

KENNETH IYOBHEBHE, EHIZEMOYA. “The Role of Women in Post Conflict Peace building in Niger Delta.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92923.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

KENNETH IYOBHEBHE, EHIZEMOYA. “The Role of Women in Post Conflict Peace building in Niger Delta.” 2020. Web. 02 Mar 2021.

Vancouver:

KENNETH IYOBHEBHE E. The Role of Women in Post Conflict Peace building in Niger Delta. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92923.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

KENNETH IYOBHEBHE E. The Role of Women in Post Conflict Peace building in Niger Delta. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92923

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Rys, Wouter Robrecht. Investigating the Shared and Distinct Mechanisms Underpinning Perceptual Decision-Making and Metacognition.

Degree: School of Psychology. Discipline of Psychology, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92921

► In order to successfully adjust to changes and learn in the sensory environment, humans must be able to detect whether or not decisions are based… (more)

▼ In order to successfully adjust to changes and learn in the sensory environment, humans must be able to detect whether or not decisions are based on reliable sources of information. Because we cannot always depend on the availability of objective feedback regarding the accuracy of our choices, computing a subjective sense of confidence to guide adaptive behavioural strategies is a necessity. Computational neuroscience has made substantial progress in parsing the basis of these metacognitive evaluations, which are reviewed in the introductory chapter of this thesis. Specifically, a set of mathematical models have been devised which hinge on the idea that the same sensory evidence accumulation processes that mediate perceptual decision-making might also govern the emergence of representations of confidence. Support for this prediction comes from invasive recording techniques in both non-human and human animals. However, many questions about exactly how these signals influence metacognitive judgements remain. For instance, it is unclear whether the decision variable is directly read-out to inform confidence, what the precise temporal dynamics of this evidence accumulation process are and what other information sources might influence the emergence of metacognitive representations. By adopting paradigms that allowed for the identification of these distinct neural signatures in non-invasive human brain recordings the current thesis aimed to elucidate the temporal dynamics as well as unique contributions of these different levels of processing along the sensorimotor hierarchy in the construction of confidence. The experiments presented in Chapter 2 aimed to address two gaps in current explorations of this relationship. Firstly, to extend on previous research by establishing that the sensory evidence accumulation process scales with choice confidence. This was confirmed in two experiments, showing that stronger build-up and higher amplitudes in this signal was associated with higher levels of confidence. This chapter further highlighted important methodological considerations for future work, by demonstrating that domain-general evidence accumulation does not simply continue to build until the choice reports and can be strategically terminated. Secondly, this study aimed to elucidate the role of motor level processes in the construction of confidence. Investigation of effector-specific mu/beta signals showed that, while contralateral motor preparation reached a fixed amplitude prior to response execution, higher activation for the unchosen alternative was associated with lower levels of confidence. These findings were complemented by an analysis of response conflict, which indicated theta band activity was similarly elevated on lower confidence trials. Additionally, the effects occur during a similar time window prior to the response, which provides a tentative indication that motor preparatory signals might indirectly influence metacognitive judgements through the expression of response conflict in theta power. Chapter 3… Advisors/Committee Members: O'Connell, Redmond.

Subjects/Keywords: Perceptual Decision-Making; Metacognition; Consciousness; Electroencephalography; EEG

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rys, W. R. (2020). Investigating the Shared and Distinct Mechanisms Underpinning Perceptual Decision-Making and Metacognition. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92921

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rys, Wouter Robrecht. “Investigating the Shared and Distinct Mechanisms Underpinning Perceptual Decision-Making and Metacognition.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92921.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rys, Wouter Robrecht. “Investigating the Shared and Distinct Mechanisms Underpinning Perceptual Decision-Making and Metacognition.” 2020. Web. 02 Mar 2021.

Vancouver:

Rys WR. Investigating the Shared and Distinct Mechanisms Underpinning Perceptual Decision-Making and Metacognition. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92921.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rys WR. Investigating the Shared and Distinct Mechanisms Underpinning Perceptual Decision-Making and Metacognition. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92921

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. DOOLEY, SUZANNA MARIA. Profiling Communication Ability in Dementia (P-CAD): Development and Validation of a Functional Cognitive-Communication Assessment.

Degree: School of Linguistic Speech & Comm Sci. Discipline of Clin Speech & Language Studies, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92953

► Introduction: Cognitive communication difficulties are characteristic of dementia with negative impact. (Bayles and Tomoeda, 2007, Hickey and Bourgeois, 2018). There is a perception that little… (more)

▼ Introduction: Cognitive communication difficulties are characteristic of dementia with negative impact. (Bayles and Tomoeda, 2007, Hickey and Bourgeois, 2018). There is a perception that little can be done to help communication and clinicians have few options to evaluate functional and retained communication skills in dementia. Research suggests that early management of communication difficulties can reduce the negative impact of communication impairment and improve quality of life (Yorkston et al., 2010, Hickey and Bourgeois, 2018). The purpose of this study was to develop and validate the P-CAD with the objective of providing clinicians with a much needed psychometrically sound assessment for people with dementia. Method: The P-CAD was developed and refined with expert opinion, comprehensive feedback from user groups and a pilot study with speech and language therapists (SLTs). Two studies informed the development of the P-CAD; a scoping review of available cognitive communication assessments for people with dementia and a practice survey of SLTs working in dementia management. One hundred people with dementia and their communication partners were recruited over a 12-month period. The P-CAD was validated against MMSE-2, Global Deterioration Scale (GDS) and Functional Linguistic Communication Inventory (FLCI). Inter-rater reliability and sensitivity to change over time (3 months) were also tested on a subgroup of individuals. Participants with dementia were at different stages of dementia and presented with a range of dementia subtypes. Results: Statistically significant correlations were found between P-CAD scores, MMSE-2 scores (r=0.830, p<0.001) and FLCI scores (r=0.863, p<0.001). There were no significant changes over time in any of the 3 scales for the participants (N=12) who completed follow-up measures. Inter rater reliability for the P-CAD (N=20) was strong between raters for all measures; GDS (ICC=0.969, p<0.001); MMSE-2 (ICC=0.997, p<0.001); FLCI (ICC=0.999, p<0.001); P-CAD (ICC=0.981, p<0.001). Findings confirm statistically significant differences (P<0.001) in MMSE-2 scores (the participant's cognitive level) and GDS levels across the different P-CAD communication support levels. Conclusions: The P-CAD is a valid and reliable cognitive communication assessment, appropriate for use with people across all subtypes and stages of dementia. P-CAD determination of levels of communication support are sensitive to the stage of dementia (GDS) and level of cognitive impairment as measured by the MMSE-2. It facilitates evaluation of functional communication abilities of people with dementia, with a specific focus on conversational skills. It guides intervention, providing measurement of change over time. It is now ready for use in clinical practice, informing interventions aimed at improving conversations between people with dementia and their communication partners. Advisors/Committee Members: Jagoe, Caroline.

Subjects/Keywords: Dementia; Communication; Assessment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DOOLEY, S. M. (2020). Profiling Communication Ability in Dementia (P-CAD): Development and Validation of a Functional Cognitive-Communication Assessment. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DOOLEY, SUZANNA MARIA. “Profiling Communication Ability in Dementia (P-CAD): Development and Validation of a Functional Cognitive-Communication Assessment.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DOOLEY, SUZANNA MARIA. “Profiling Communication Ability in Dementia (P-CAD): Development and Validation of a Functional Cognitive-Communication Assessment.” 2020. Web. 02 Mar 2021.

Vancouver:

DOOLEY SM. Profiling Communication Ability in Dementia (P-CAD): Development and Validation of a Functional Cognitive-Communication Assessment. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DOOLEY SM. Profiling Communication Ability in Dementia (P-CAD): Development and Validation of a Functional Cognitive-Communication Assessment. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. AL-SHIBLAWI, NADHIM KAMIL. Role of kynurenine on platelet's function and beyond.

Degree: School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92970

► Kynurenine is a metabolite of the amino acid tryptophan by the action of the tryptophan dioxygenase enzyme in the liver and the ubiquitous indolamine dioxygenase… (more)

▼ Kynurenine is a metabolite of the amino acid tryptophan by the action of the tryptophan dioxygenase enzyme in the liver and the ubiquitous indolamine dioxygenase enzyme in other tissues. Although it has been shown that kynurenine participates in different processes involving the central nervous-, immune- and cardiovascular- systems, its effect on platelet function has not been yet investigated. In this study, it is shown for the first time that kynurenine inhibits collagen-, adenosine diphosphate-, thromboxane- and arachidonic acid- induced platelet aggregation. The mechanism by which kynurenine modulates platelet function involves the activation of the adenylyl cyclase (AC) enzyme and of the reduced and oxidized heme forms of the soluble guanylyl cyclase (sGC) enzyme. Activation of those enzymes leads to an increase of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) respectively. Kynurenine phosphorylates the vasodilator stimulated phosphoprotein (VASP) by cAMP- and cGMP-dependent protein kinases. VASP participates in cytoskeleton redistribution during platelet shape change and in GPIIb/IIIa activation. Kynurenine may represent a natural endothelial derived inhibitor of platelet aggregation that can activate both, adenylyl cyclase and guanylyl cyclase. Kynurenine may activate the soluble guanylyl cyclase enzyme when the enzyme is refractory to NO and therefore may represent a physiological back up system for NO and a new therapeutic approach in pathological conditions where oxidative stress inactivates platelet response to NO. In fact, studying the binding site of kynurenine to both forms of soluble guanylyl cyclase may open the door for the development of novel therapeutic compounds that could activate both forms of the enzyme. Having found that kynurenine have the ability to inhibit platelet aggregation induced by collagen, ADP, the thromboxane analogue U46619 and arachidonic acid. The effect of kynurenine on platelet function resulted to be cGMP and cAMP dependent, meaning that the effect of this tryptophan metabolite can be linked with most of the major pathways involved in platelet aggregation. Those findings, together with the already known participation of kynurenine in cancer biology, led us to investigate its potential effect on TCIPA. TCIPA refers to the ability of cancer cells to aggregate platelets and constitutes a crucial step during cancer cell invasion, angiogenesis and during the development of metastatic foci. It has been shown that tumour cell lines differ in their capability to induce platelet aggregation and that the mechanism by which TCIPA takes place can also vary from one cell line to another. Kynurenine (100-500 ?M) significantly inhibited TCIPA induced by A549, Hela, HT-29, SW-480 and HCC-1954 cells. However, the amount of kynurenine produced by the different cell lines in vitro did not justify and did not correlate with the differences in their capability to induce platelet aggregation. Pharmacological modulation of kynurenine generation by the induction… Advisors/Committee Members: Tajber, Lidia.

Subjects/Keywords: Kynurenine; platelet aggregation; tumor cell induced platelet aggregation; conditioned media and TCIPA; kynurenine mechanism of action; TCIPA

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APA (6^th Edition):

AL-SHIBLAWI, N. K. (2020). Role of kynurenine on platelet's function and beyond. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

AL-SHIBLAWI, NADHIM KAMIL. “Role of kynurenine on platelet's function and beyond.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

AL-SHIBLAWI, NADHIM KAMIL. “Role of kynurenine on platelet's function and beyond.” 2020. Web. 02 Mar 2021.

Vancouver:

AL-SHIBLAWI NK. Role of kynurenine on platelet's function and beyond. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

AL-SHIBLAWI NK. Role of kynurenine on platelet's function and beyond. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. DINNEEN, KATE ANNE. Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates.

Degree: School of Medicine. Discipline of Clinical Medicine, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92977

► Gastroesophageal junction adenocarcinomas (GEJA) have increased in incidence in the Western world over the last 50 years, a trend largely attributed to lifestyle factors including… (more)

▼ Gastroesophageal junction adenocarcinomas (GEJA) have increased in incidence in the Western world over the last 50 years, a trend largely attributed to lifestyle factors including obesity and gastroesophageal reflux disease. Their prognosis is poor, and treatment is often complicated by resistance to conventional anti-cancer therapies. Current drug therapies and management strategies used in GEJA have been largely inferred from studies looking at gastric and oesophageal adenocarcinomas, however, a growing school of thought exists which believes that GEJAs have a distinct molecular profile. Investigation of the molecular biology of these tumours may therefore provide us with a novel target for drug therapies, in addition to potential prognostic biomarkers for use in the clinical setting. Cancer stem cells (CSC) have been extensively investigated across a range of solid organ and haematological malignancies due to their known role in tumorigenesis, invasion, metastasis and drug resistance, yet little is known about their role in GEJA. This thesis investigates the presence of CSC-like cells in GEJA by analysis of the expression patterns of mRNAs, miRNAs and proteins which have previously been described as CSC markers. Molecular markers of EMT were additionally investigated using the same techniques due to the known role of EMT in the regulation of CSCs. This expression data was analysed to seek a significant molecular expression pattern that may be of use in identification, prognostication and/or treatment of aggressive disease. Chapter 1 presents a background on GEJA, with particular emphasis on advances in tumour classification and drug therapies currently used in the treatment of this disease. Chapter 2 describes the lab techniques used throughout this work, including quantitative real time PCR and immunohistochemical analysis of tissue microarrays. Chapter 3 presents the expression data for each mRNA, miRNA and protein analysed in this study and correlates each individual marker with patient-specific clinical outcomes. Chapter 4 describes the clinical utility of a predictive model based upon the combined expression data from the previous chapter. This chapter additionally interrogates the mRNA and miRNA expression data to determine the signalling pathways involved in the regulation of CSC-like cells in GEJA. Finally, chapter 5 discusses the significance of these findings in the context of the current literature. Advisors/Committee Members: Sheils, Orla.

Subjects/Keywords: Epithelial Mesenchymal Transition; Cancer Stem Cells; Gastroesophageal Junction Adenocarcinoma

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APA (6^th Edition):

DINNEEN, K. A. (2020). Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92977

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DINNEEN, KATE ANNE. “Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92977.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DINNEEN, KATE ANNE. “Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates.” 2020. Web. 02 Mar 2021.

Vancouver:

DINNEEN KA. Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92977.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DINNEEN KA. Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92977

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. IOANNOU, ANDRIANA. Enhancing Network Performance and Consumer Experience in Named Data Networking (NDN).

Degree: School of Computer Science & Statistics. Discipline of Computer Science, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92967

► Named Data Networking (NDN) is an Information-Centric Networking (ICN) architecture proposed as an alternative to the current Internet infrastructure. Using the publish-subscribe paradigm and a… (more)

▼ Named Data Networking (NDN) is an Information-Centric Networking (ICN) architecture proposed as an alternative to the current Internet infrastructure. Using the publish-subscribe paradigm and a standardised naming scheme, ICN allows the components of a publish-subscribe solution to interact without tight coupling between them. NDN supports a hierarchical naming scheme that identifies chunks of an object resource such as a service, web page, file, etc., using a content identifier. Content identifiers should be location-free and all identical contents should share the same content identifier. This way, content can be freely distributed and cached within the infrastructure utilising the capacity of routers on the path from a source to a destination, called on-path caching. A hierarchical naming scheme may also enable the functionality of request aggregation at routers. The purpose of this mechanism is to aggregate close-in-time requests for the same content and to propagate only the first of them to a content source(s). This thesis focuses on the exploration of the on-path caching feature and the request aggregation mechanism of NDN to enhance the network performance and the consumer experience within an Internet Service Provider (ISP)/Autonomous System (AS) network by reducing the intra and inter-network traffic and the content delivery times of consumers. By reducing the intra and inter-network traffic of an ISP/AS network, a reduction of the content delivery times of consumers is also expected. Popularity and Location-based Caching (PLbC) is a lightweight caching algorithm that utilises the criterion of content popularity and the criterion of the location of routers on delivery paths by incorporating them into the caching decision process to construct a probability. PLbC has been shown to outperform the caching policy proven to perform the best among a number of caching policies evaluated in this thesis, i.e. PC+. PLbC has been shown to yield a 3-6% higher probability of retrieving the content locally from the caches of routers compared to PC+, while caching 11-15% less content within the local ISP/AS network. Yet, PLbC is unable to fully utilise the cache capacity of routers as this approaches the catalog size, i.e. the number of object resources within a network. Content Sharing-Extended Request Aggregation (CS-ERA) is a mechanism that focuses on content sharing between consumers that request to retrieve the same object resource. For this purpose, CS-ERA exploits the mechanism of request aggregation to bound successive requests to be satisfied within the boundaries of the local ISP/AS network, if a local replica exists. To increase the number of successive requests to be bounded, CS-ERA extends the naming granularity to which request aggregation is ap- plied from a chunk to an object resource. CS-ERA has been shown to outperform the original request aggregation mechanism by aggregating 11-17% more object requests within an ISP/AS network, while satisfying 52-81% more chunks of an object resource locally. The… Advisors/Committee Members: Weber, Stefan.

Subjects/Keywords: Named Data Networking (NDN); Information Centric Networking (ICN); On-path Caching; Request Aggregation; Network Performance; Consumer Experience; Intra and Inter-network Traffic; Content Delivery Times; Taxonomy; Quantitative Comparison

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

IOANNOU, A. (2020). Enhancing Network Performance and Consumer Experience in Named Data Networking (NDN). (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92967

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

IOANNOU, ANDRIANA. “Enhancing Network Performance and Consumer Experience in Named Data Networking (NDN).” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92967.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

IOANNOU, ANDRIANA. “Enhancing Network Performance and Consumer Experience in Named Data Networking (NDN).” 2020. Web. 02 Mar 2021.

Vancouver:

IOANNOU A. Enhancing Network Performance and Consumer Experience in Named Data Networking (NDN). [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92967.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

IOANNOU A. Enhancing Network Performance and Consumer Experience in Named Data Networking (NDN). [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92967

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. CARDY, NATHAN. Physical function in patients undergoing arthroscopic meniscus surgery of the knee.

Degree: School of Medicine. Discipline of Physiotherapy, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92979

► Current evidence does not support the primary use of arthroscopic partial meniscectomy (APM) in the treatment of middle-aged patients with a meniscus tear in a… (more)

▼ Current evidence does not support the primary use of arthroscopic partial meniscectomy (APM) in the treatment of middle-aged patients with a meniscus tear in a degenerative knee. Findings of these studies are based on Patient Reported Outcome Measures (PROMs). Objective functional performance in patients undergoing APM are poorly reported and research has not been consolidated on this topic. Arthroscopic meniscus surgery continues to be a frequently performed procedure despite recent guidelines; the rationale for surgical treatment in patients with meniscus injuries is not clearly defined. The aim of this thesis was to investigate expectations, functional performance and activity level in a cross sectional population of patients undergoing arthroscopic meniscus surgery of the knee. Two systematic reviews were undertaken to summarise current research on this topic. The first systematic review examined self-reported function and measures of strength in young patients undergoing APM. The second systematic review and meta-analyses examined measures of objective physical function in patients undergoing arthroscopic meniscus surgery. A longitudinal cohort study (Trinity Meniscus Study: TRIMS) examined objective and self- reported function in patients undergoing arthroscopic meniscus surgery. Pre-operative baseline assessments were carried out, and patients were followed up for one year post- operatively with PROMs measured at pre-op, three, six and twelve months post-op. Objective measures of physical function were assessed at pre-op baseline and six months post-op follow up. Functional performance was measured using isokinetic strength assessment of the quadriceps and hamstring muscles, as well as a battery of hop tests (Single Leg Hop(SLH), Triple Hop for Distance (THD) and Six-metre Timed Hop(6MH)). Performance was compared to contralateral leg as control and change in physical function over time was reported. Rationale for arthroscopic meniscus surgery was examined in a study collecting self- reported expectation questionnaires from patients and clinicians. Additional analyses of data from the TRIMS study was also used to compare reasons for surgery from patients' and surgeons' perspectives. Literature review found that objective measures of functional performance are poorly studied across all age groups undergoing arthroscopic meniscus surgery. Strength appears to be decreased for up to one year following APM in younger adults, but there is a complete lack of self-reported outcome data in younger populations. Deficits in functional performance are reported both pre and post-operatively in middle aged APM cohorts and RCTs. The TRIMS study found deficits in functional performance compared to contralateral leg, both pre-operatively (P<.01 all measures) and post-operatively (P<.05 all measures) in middle aged patients undergoing APM. These functional deficits were found to improve bilaterally following surgery but no difference in improvement was found on strength or SLH performance compared to contralateral leg. This… Advisors/Committee Members: Wilson, Fiona, Thorlund, Jonas Bloch.

Subjects/Keywords: meniscus; knee; function; arthroscopic meniscectomy; physiotherapy; sports medicine; strength; hop tests

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

CARDY, N. (2020). Physical function in patients undergoing arthroscopic meniscus surgery of the knee. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92979

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

CARDY, NATHAN. “Physical function in patients undergoing arthroscopic meniscus surgery of the knee.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92979.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

CARDY, NATHAN. “Physical function in patients undergoing arthroscopic meniscus surgery of the knee.” 2020. Web. 02 Mar 2021.

Vancouver:

CARDY N. Physical function in patients undergoing arthroscopic meniscus surgery of the knee. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92979.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

CARDY N. Physical function in patients undergoing arthroscopic meniscus surgery of the knee. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92979

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Hanlon, Megan. Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis.

Degree: School of Medicine. Discipline of Clinical Medicine, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93001

► Macrophages are an exquisitely plastic pool of innate cells critically involved in directing the immune response in RA. Upon entry into the synovium, peripheral blood… (more)

▼ Macrophages are an exquisitely plastic pool of innate cells critically involved in directing the immune response in RA. Upon entry into the synovium, peripheral blood monocytes differentiate into the dichotomous M1 (pro-inflammatory) or M2 (anti-inflammatory) macrophage activation states. However, it is now known that macrophages are heterogeneous both in function and origin with many macrophages seeded during embryonic development independently. Despite this, the precise nature and function of infiltrating monocyte-derived macrophages and their precursor cells are poorly defined in RA with even less known about RA synovial tissue macrophages. Therefore, the aims of this thesis are to elucidate the distinct pathogenic functions, bioenergetic demands and activation status of monocytes, monocyte-derived macrophages and synovial tissue macrophage subsets in RA. In this study we demonstrate that circulating RA CD14+ monocytes are primed to produce pro-inflammatory mediators, a phenotype indicative of M1-like macrophage polarisation. Metabolic analysis of RA monocytes using the Seahorse Flux analyser reveals a robust boost in both OXPHOS and glycolysis in RA CD14+ monocytes compared to HC. Interestingly, the hyper-inflammatory, hyper-metabolic phenotype of RA monocytes persists following differentiation into ex vivo macrophages. RA M1 macrophages replicate the inflammatory memory bias of their precursor cells demonstrating heightened glycolysis and mitochondrial respiration coupled with altered mitochondrial morphology compared to HC. In addition, we demonstrate a consistent upregulation of glycolytic machinery indicating fundamental abnormalities in glucose processing in RA myeloid cells. Furthermore, analysis of polarised RA M1/M2 macrophages reveals divergent inflammatory, bioenergetic and phagocytic functions. Marked transcriptional variance was indicated by RNA-seq, with a key role for STAT3 activation in macrophage polarisation identified. Mechanistically, we demonstrate that the hyper-inflammatory and metabolic phenotype of RA monocytes and M1 macrophages, is mediated through STAT3 phosphorylation whereby inhibition of STAT3 activity switches the pathogenic phenotype of myeloid cells for resolution of inflammation. Distinct subsets of tissue macrophage in the inflamed RA synovium remain largely unexplored. In this thesis we phenotypically characterise RA synovial tissue macrophages revealing a spectrum of macrophage activation states that don?t conform to the binary M1/M2 framework in vivo. Within this spectrum we identify for the first time, that the dominant macrophage population residing in the RA synovium is a transitional subset of tissue-resident CD206+CD163+ macrophages that display elevated CD40 expression. We demonstrate that this subset is enriched in synovial tissue compared to fluid but specifically in RA synovium compared to OA and PsA synovial pathotypes. Furthermore, the CD206+CD163+ macrophage subset is present in healthy synovial tissue but does not express CD40. CD206+CD163+ and CD206-CD163-… Advisors/Committee Members: Fearon, Ursula.

Subjects/Keywords: Synovial Tissue; Immunometabolism; Rheumatoid Arthritis; Macrophage

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hanlon, M. (2020). Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hanlon, Megan. “Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hanlon, Megan. “Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis.” 2020. Web. 02 Mar 2021.

Vancouver:

Hanlon M. Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hanlon M. Macrophages are critical drivers of synovial inflammation in Rheumatoid Arthritis. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. ORR, JOANNA. Ageing outcomes in women and men in Ireland: the role of the religious social context.

Degree: School of Medicine. CentreFor Medical Gerontology, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93002

► Aim & background: The aim of this thesis is to explore how the religious social context in Ireland has helped shape the health and ageing… (more)

▼ Aim & background: The aim of this thesis is to explore how the religious social context in Ireland has helped shape the health and ageing outcomes of older women and men. Understanding the factors behind the ability to maintain physical, cognitive and psychosocial wellbeing is crucial in the context of rapidly aging populations. Research recognises differences in health trajectories for men and women, but there is a lack of understanding of the mechanisms behind the role of gender in ageing. Within the Irish context, the impact of social and individual religiosity on women's social roles and ageing outcomes are particularly important. The effects of religiosity on health have been widely studied, but little consensus exists on the pathways that link religiosity and ageing. Methods: Four studies were conducted using nationally representative data from The Irish Longitudinal Study on Ageing (TILDA). Data was analysed using multilevel modelling techniques to longitudinally test causal relationships between religious belief and practice, parity and ageing outcomes in older Irish men and women. A fifth study combined quantitative data from TILDA with qualitative data from Irish women aged 65 and over. Qualitative data was collected to complement and further illuminate results from the quantitative phase in a mixed methods analysis of wellbeing in later life. Results: Findings of both quantitative and qualitative data showed that religion and the religious social context are associated with health in late life through complex pathways. Religious attendance in those who are religious was found to be the factor most strongly associated with health. More frequent religious attendance was associated with lower mortality risk, lower depressive symptoms and higher wellbeing. Results for a link between religious attendance and physical function and cognition were inconclusive. Qualitative data suggested the positive associations of religious attendance may be explained by social connectedness and psychological benefits. However, qualitative data also illustrated possible negative effects of religiosity in Ireland. Conclusion: Religious involvement in those who are religious is likely to be related to health outcomes through social connectedness and other factors which support physical and mental health in Ireland. Advisors/Committee Members: McGarrigle, Christine.

Subjects/Keywords: Ageing; Religion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ORR, J. (2020). Ageing outcomes in women and men in Ireland: the role of the religious social context. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93002

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ORR, JOANNA. “Ageing outcomes in women and men in Ireland: the role of the religious social context.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93002.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ORR, JOANNA. “Ageing outcomes in women and men in Ireland: the role of the religious social context.” 2020. Web. 02 Mar 2021.

Vancouver:

ORR J. Ageing outcomes in women and men in Ireland: the role of the religious social context. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93002.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ORR J. Ageing outcomes in women and men in Ireland: the role of the religious social context. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93002

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. O'GORMAN, PHILIP ANTHONY. Exercise Therapy as a Treatment for Chronic Liver Disease.

Degree: School of Medicine. Discipline of Physiotherapy, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93005

► Hepatitis C (HCV) and Non-Alcoholic Fatty Liver Disease (NAFLD) are among the leading causes of chronic inflammatory liver disease. HCV and NAFLD present with numerous… (more)

▼ Hepatitis C (HCV) and Non-Alcoholic Fatty Liver Disease (NAFLD) are among the leading causes of chronic inflammatory liver disease. HCV and NAFLD present with numerous hepatic and extrahepatic features which culminates in an increased cardiometabolic risk and accelerates liver disease progression. The extensive benefits of physical activity (PA) and high cardiorespiratory fitness (CRF) are well recognised in both the general population and in many chronic diseases but the extent of the benefits in HCV and NAFLD populations remains unclear. This thesis aimed to establish the cardiometabolic profile as well as CRF and PA levels in a cohort of individuals with HCV and NAFLD and subsequently determine the effects of an aerobic exercise intervention (EI) for treating the hepatic and extrahepatic features of both HCV and NAFLD. Study 1 aimed to determine the effects of a 12-week aerobic EI on cognitive and cardiometabolic health in a cohort of individuals with HCV. 75 participants with HCV-related cognitive impairment completed the baseline assessment. Overall, there were low PA levels with only 25% of participants achieving the recommended weekly PA guidelines and 59% of participants had poor CRF. 43% of participants also had evidence of central obesity, 24% had metabolic syndrome, 90% reported moderate/severe fatigue, 78% reported poor sleep quality and 39% reported depression. Following the assessment, 31 participants completed the EI (exercise group n=13, control group n=18) which resulted in significant improvements in measures of cognitive function, CRF and quality of life. When participants were reassessed 12 weeks after the completion of the EI, the benefits were not sustained. Study 2a aimed to determine the cardiometabolic profile, CRF and PA levels in a cohort of individuals with NAFLD and a total of 87 participants completed the assessment. 20% of the cohort were achieving the PA guidelines, 87% had poor CRF, 100% were overweight or obese, 72% had metabolic syndrome, 92% had central obesity,79% reported moderate/severe fatigue and 64% reported poor sleep quality. Participants with more severe hepatic fibrosis had significantly worse CRF compared to those with minimal/moderate hepatic fibrosis. Following Study 2a, Study 2b aimed to determine the effects of a 12-week aerobic EI on the hepatic and extrahepatic features of NAFLD. A total of 24 participants completed the EI (exercise group n=16, control group n=8). Following the EI, there was a significant regression in histologically measured hepatic fibrosis and hepatocellular ballooning which was paralleled by significant improvements in CRF and anthropometry, but no participants achieved the published benchmark for clinically significant weight loss (7-10%). Upon further analysis, the significantly improved histological endpoints were associated with improvements in CRF. When participants were reassessed after 12 and 52 weeks, the majority of the benefits were not sustained. Study 3 aimed to determine the perceived barriers and motivators to engaging in PA… Advisors/Committee Members: Gormley, John.

Subjects/Keywords: NAFLD; Liver disease; Hepatitis C; Exercise therapy; Physical activity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

O'GORMAN, P. A. (2020). Exercise Therapy as a Treatment for Chronic Liver Disease. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93005

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

O'GORMAN, PHILIP ANTHONY. “Exercise Therapy as a Treatment for Chronic Liver Disease.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93005.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

O'GORMAN, PHILIP ANTHONY. “Exercise Therapy as a Treatment for Chronic Liver Disease.” 2020. Web. 02 Mar 2021.

Vancouver:

O'GORMAN PA. Exercise Therapy as a Treatment for Chronic Liver Disease. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93005.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

O'GORMAN PA. Exercise Therapy as a Treatment for Chronic Liver Disease. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93005

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. O'BRIEN, CAROL. Functional assessment of non-coding regulatory variants in familial breast cancer.

Degree: School of Genetics & Microbiology. Discipline of Genetics, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93021

► Breast cancer is the most common cancer in Irish women, with almost 3,000 cases diagnosed every year. It often runs in families, and some women… (more)

Subjects/Keywords: Breast cancer; Non-coding variants; Genetics

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APA (6^th Edition):

O'BRIEN, C. (2020). Functional assessment of non-coding regulatory variants in familial breast cancer. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

O'BRIEN, CAROL. “Functional assessment of non-coding regulatory variants in familial breast cancer.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

O'BRIEN, CAROL. “Functional assessment of non-coding regulatory variants in familial breast cancer.” 2020. Web. 02 Mar 2021.

Vancouver:

O'BRIEN C. Functional assessment of non-coding regulatory variants in familial breast cancer. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

O'BRIEN C. Functional assessment of non-coding regulatory variants in familial breast cancer. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. SCHIPANI, ROSSANA. 3D bioprinting of cartilage-mimetic implants for biological joint resurfacing.

Degree: School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93022

► A major challenge in the field of tissue engineering and regenerative medicine is the development of effective therapies for treating large cartilage or osteochondral defects… (more)

▼ A major challenge in the field of tissue engineering and regenerative medicine is the development of effective therapies for treating large cartilage or osteochondral defects and ultimately regenerating whole osteoarthritic joints. The objective of this thesis was to 3D bioprint cell-laden biomaterials with biomimetic mechanical properties as implants for regenerating large osteochondral defects. To this end, a finite element modelling (FEM) strategy was first developed to design the 3D printed polycaprolactone (PCL) networks with user-defined mechanical properties. These PCL networks were then combined with an alginate-gelatin methacryloyl (gelMA) interpenetrating network (IPN) hydrogel to develop 3D bioprinted constructs that were both mechanically functional and supportive of mesenchymal stromal cells (MSCs) chondrogenesis. When the IPN hydrogels were reinforced with a PCL network characterized by relatively high tension-compression nonlinearity, the resulting composites possessed equilibrium and dynamic properties matching or approaching those of native articular cartilage. In addition, when a co-culture of bone marrow-stromal cells (BMSCs) and chondrocytes (CCs) was encapsulated within the IPN hydrogel, the 3D bioprinted composite provided an environment conducive to robust chondrogenesis with little evidence of hypertrophy. The next stage of this thesis explored the use of 3D bioprinting to fabricate mechanically reinforced bi-layered constructs, consisting of spatially defined hyaline and hypertrophic cartilage-like layers for osteochondral tissue engineering. To engineer phenotypically stable articular cartilage in the chondral region two different approaches were explored: 1) a co-culture of BMSCs and CCs was loaded in an alginate-gelMA IPN bioink or 2) dynamic compression was applied to constructs containing only BMSCs. While both approaches showed promise, printing a co-culture of BMSCs and CCs was found to be a particularly effective approach for engineering phenotypically stable cartilage in the chondral layer of osteochondral constructs in vitro. Finally, a novel multiple-tool 3D bioprinting strategy was developed to engineer 'off-the-shelf' bi-layered implants designed to treat large osteochondral defects in goats or to resurface the whole glenohumeral joint in rabbits. BMSCs and/or specific growth factors were incorporated into each layer of the implant to promote chondrogenesis in the chondral layer and vascularization and osteogenesis in the osseous layer. Although significant changes are required to improve the in vivo outcomes, the concept of engineering spatially complex patterns of growth factors within bioprinted implants was demonstrated. To conclude, this thesis describes a novel multiple-tool biofabrication framework for engineering biological joint resurfacing implants. By integrating FEM and bioprinting technology it was possible to design cell-laden constructs with cartilage-mimetic biomechanical properties, and to spatially direct the formation of phenotypically stable articular… Advisors/Committee Members: Kelly, Daniel.

Subjects/Keywords: 3D bioprinting; tissue engineering; articular cartilage; finite element modelling; biomimetic implants; in vivo models

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APA (6^th Edition):

SCHIPANI, R. (2020). 3D bioprinting of cartilage-mimetic implants for biological joint resurfacing. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SCHIPANI, ROSSANA. “3D bioprinting of cartilage-mimetic implants for biological joint resurfacing.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SCHIPANI, ROSSANA. “3D bioprinting of cartilage-mimetic implants for biological joint resurfacing.” 2020. Web. 02 Mar 2021.

Vancouver:

SCHIPANI R. 3D bioprinting of cartilage-mimetic implants for biological joint resurfacing. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93022.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SCHIPANI R. 3D bioprinting of cartilage-mimetic implants for biological joint resurfacing. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93022

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Roucan, Marie. Designer Nonplanar Porphyrins with Tuned Properties for Application as Bifunctional Organocatalyst.

Degree: School of Chemistry. Discipline of Chemistry, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93029

► The aim of this research was to investigate the use of different free base nonplanar porphyrins as bifunctional catalysts. This involved the tailored design of… (more)

▼ The aim of this research was to investigate the use of different free base nonplanar porphyrins as bifunctional catalysts. This involved the tailored design of various porphyrin catalysts and the subsequent testing of said systems in catalytic screening reactions with small organic molecules. Porphyrins are a unique class of natural compounds that are omnipresent in nature. This results in them being involved in many important biological processes for example oxygen transport, electron transfer and oxidation reactions as well as photosynthesis. These versatile molecules can also be found in cofactors in nature and are crucial regulatory effectors in many biochemical processes. Nowadays the chemistry of porphyrins is well established and they can be found in a wide area of applications. However, porphyrins usually act as a simple ligands where the actual desired effect is subsequent to the formation of a tetrapyrrole metal complex. Most of the time the very interesting inner core N and NH units are deemed inaccessible, albeit they could offer an interesting entry point to a plethora of new applications and reactions. This work focuses on taking advantage of these active inner units of the porphyrin by purposely fine-tuning and modulating the porphyrin periphery and hence making these formerly esoteric units available through the introduction of precise distortion to the porphyrin macrocycle. This is envisioned to lead to distorted free base tetrapyrroles that have tuneable properties and form complexes through weak interactions of the core with other molecules and therefore represent interesting candidates for organocatalysts. In order to achieve this goal the project was divided into two main parts: a) The synthesis of a library of nonplanar porphyrins with various degrees of distortion. b) The investigation into the activity of these molecules as effective catalysts in 1,4-addition reactions. The first method employed to obtain the essential distortion of the porphyrin macrocycle and thus make the N and NH units of the porphyrin macrocycle available for catalytic activity was through crowding of the periphery of the porphyrin core. The synthesis of a large library of nonplanar highly substituted porphyrins was then achieved through condensation reactions. Therefore, a series of aldehydes with different electron donating substituents were chosen together with two types of substituted pyrrole units resulting in two families of highly substituted porphyrins. The electron donating effects of the respective aldehydes were quantified using Hammett?s values to strategically design and fine-tune the electronic properties of the porphyrin macrocycles. The strong electron donating effects of the substituents on the aryl units decreases the electrophilicity of the aldehyde group and thus its reactivity towards pyrrole molecules. More importantly the presence of strong electron donating groups induces a very high basicity to the inner core functional groups of the porphyrin, which could result in an enhanced… Advisors/Committee Members: Senge, Mathias.

Subjects/Keywords: porphyrins; nonplanar porphyrins; spectroscopic analysis; conformation analysis; organocatalysis; michael additions; hydrogen bond; basicity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roucan, M. (2020). Designer Nonplanar Porphyrins with Tuned Properties for Application as Bifunctional Organocatalyst. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93029

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Roucan, Marie. “Designer Nonplanar Porphyrins with Tuned Properties for Application as Bifunctional Organocatalyst.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93029.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Roucan, Marie. “Designer Nonplanar Porphyrins with Tuned Properties for Application as Bifunctional Organocatalyst.” 2020. Web. 02 Mar 2021.

Vancouver:

Roucan M. Designer Nonplanar Porphyrins with Tuned Properties for Application as Bifunctional Organocatalyst. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93029.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Roucan M. Designer Nonplanar Porphyrins with Tuned Properties for Application as Bifunctional Organocatalyst. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93029

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. DOWLING, CONOR MARK. Urban resilience based systems managment.

Degree: School of Business. Discipline of Business & Administrative Studies, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93027

► As a result of climate change cities face challenges of growing complexity and uncertainties including increasing magnitude and volume of droughts, storms and flooding among… (more)

▼ As a result of climate change cities face challenges of growing complexity and uncertainties including increasing magnitude and volume of droughts, storms and flooding among other extreme weather events. Traditional risk management, based on probabilistic quantitative methods, are no longer sufficient to address the unpredictability and magnitude of these events. These challenges are further complicated by the increased interdependency of many of society's urban systems which presents a fundamental challenge to even the most comprehensive risk analysis. In response to this problem urban resilience has grown in popularity as a way to address the impacts of climate change and to maintain the functionality of urban systems during disaster events. However urban resilience remains siloed in its application to either built infrastructure systems or the communities they support and there is a significant gap in the literature as to how these two resilience types can be brought together. The early integration of resilience into the design of critical infrastructure systems management is needed to complement the existing knowledge-base of risk analysis and to address the emerging issues associated with complexity and uncertainty. This thesis argues for the significance of resilience in urban development and the necessity for practitioners to engage with the emerging concept of viewing critical infrastructure as part of a wider complex socio-technical system (STS). The research aims to develop and trial professional approaches to embed resilience within design processes through an empirical contribution with the development of a Resilience Management Framework (RMF). This framework aims to provide decision makers with a baseline measurement of STS resilience and suggests how resilience capabilities may be improved. The framework is tested with a case study which helps to develop practical pathways to resilience attainment. This study is complemented by expert interviews which aim to elicit effective and practical approaches to the implementation of conditions for urban resilience. The study identified sources of resilience and resilience dynamics that require management in the context of STS management. The thesis is concluded with a discussion on the importance of new professional tools for facilitating the delivery of resilient systems and with the conclusions of the study. Advisors/Committee Members: Rhodes, Mary.

Subjects/Keywords: Complex Systems; Indicators; Flooding; Climate Change; Geographic Information System; Urban resilience

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APA (6^th Edition):

DOWLING, C. M. (2020). Urban resilience based systems managment. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93027

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DOWLING, CONOR MARK. “Urban resilience based systems managment.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93027.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DOWLING, CONOR MARK. “Urban resilience based systems managment.” 2020. Web. 02 Mar 2021.

Vancouver:

DOWLING CM. Urban resilience based systems managment. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93027.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DOWLING CM. Urban resilience based systems managment. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93027

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. ELLIOTT, RORY. Metallo-Supramolecular and Bioinspiried Coordination Compounds for H2O Oxidation.

Degree: School of Chemistry. Discipline of Chemistry, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93050

► Ever-increasing energy demands and associated climate change issues impose imperative scientific challenges to society. Switching to an economy based on the carbon-free, high density energy… (more)

▼ Ever-increasing energy demands and associated climate change issues impose imperative scientific challenges to society. Switching to an economy based on the carbon-free, high density energy carrier H2 represents a promising solution to the problems posed by fossil fuel consumption. However, current methods of H2 production are expensive and unsustainable. Solar H2O splitting presents an attractive approach for renewably generating H2 in abundance. Despite this, current technological breakthroughs in this area are hampered by a lack of efficient, cost-effective catalysts for the endergonic, proton-coupled 4 electron O2 evolution half-reaction (OER). Therefore, the development of H2O oxidation catalysts (WOCs) based on earth-abundant materials to provide low-energy pathways for the OER is of utmost importance to satisfy global energy needs in an environmentally friendly manner. Due to the thermodynamic and kinetic barriers to the OER, current catalysts for this reaction suffer from poor activity or instability. Moreover, many state-of-the-art WOCs rely on costly rare-earth elements. Metal-organic frameworks (MOFs) are metallo supramolecular materials with well defined cavities and unprecedented surface areas which can incorporate redox active building units. Thus, MOFs represent a hopeful class of compounds to catalyse H2O oxidation. This thesis aims to prepare and use metallo-supramolecular assemblies such as MOFs, metal-oxo clusters and complexes constructed using earth abundant elements as catalysts for the challenging OER. The results presented in this thesis include the synthesis and structural characterisations of several metalloenzyme inspired materials. Moreover, the exploration of these hybrid organic inorganic systems as WOCs towards artificial photosynthetic applications is described. Ultimately, post-catalytic experiments are discussed which attribute the observed OER activities to various molecular species. Advisors/Committee Members: SCHMITT, WOLFGANG.

Subjects/Keywords: Artificial Photosynthesis; Water Splitting; Water Oxidation; Metal-Organic Framework; MOF; Porphyrin; Photocatalysis; Coordination Compound; Hybrid Materials; Oxygen Evolution Reaction; OER; Supramolecular Materials

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APA (6^th Edition):

ELLIOTT, R. (2020). Metallo-Supramolecular and Bioinspiried Coordination Compounds for H2O Oxidation. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93050

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ELLIOTT, RORY. “Metallo-Supramolecular and Bioinspiried Coordination Compounds for H2O Oxidation.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93050.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ELLIOTT, RORY. “Metallo-Supramolecular and Bioinspiried Coordination Compounds for H2O Oxidation.” 2020. Web. 02 Mar 2021.

Vancouver:

ELLIOTT R. Metallo-Supramolecular and Bioinspiried Coordination Compounds for H2O Oxidation. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93050.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ELLIOTT R. Metallo-Supramolecular and Bioinspiried Coordination Compounds for H2O Oxidation. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93050

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. PEREZ DENIA, MARTA. Objective and Quantitative acoustic-analysis of musicians dystonia.

Degree: School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93052

► Musician s Dystonia (MD) is the most common movement disorder affecting musicians. Being a specific phenotype of Dystonia, MD is a focal, task-specific and painless… (more)

▼ Musician s Dystonia (MD) is the most common movement disorder affecting musicians. Being a specific phenotype of Dystonia, MD is a focal, task-specific and painless disorder that affects motor control during musical performance, characterised by abnormal muscle contractions. With an estimate of 1-2% in professional musicians affected, MD has been reported in virtually every instrument, including keyboard, strings, plectrum, woodwind, brass and drums. The main phenotypes associated with MD are Hand Musician s Dystonia (HD) and Embouchure Dystonia (ED). Nevertheless, the disorder has been reported to manifest in several body regions (e.g. arm, hand, lower cranial structure, cervical muscles, breathing muscle, vocal cords, legs). There exists a lack of research in MD and this is reflected in the absence of objective methodologies for its assessment, specifically those that meet the requirements of ease of use in clinical environments. There is clinical need for a tool that ensures such requirements and that would allow MD assessment alongside the Dystonia-triggering musical instrument. Such a tool would also provide a standardised methodology for longitudinal studies of MD. The aim of this research was to address these challenges by developing a software platform for objective and quantitative acoustic-analysis of Musician s Dystonia. The main outcomes of the research presented in this thesis are as follows: An experimental set-up for audio-recordings and a protocol of musical exercises for ED evaluation. The experimental set-up enables subsequent automated analysis of the acquired recordings. The protocol permits studying ED across the disorder s task-specific domains. ED musical technique-specificity is evaluated by means of sequenced and sustained notes. Register-specificity is tested by notes encompassing complete playing and dynamic ranges. Sequenced notes played at slow, medium and fast tempos enable speed-specificity study. Software analysis for Embouchure Dystonia s severity assessment. The software platform allows automated evaluation across the following specific acoustic domains by extracting key acoustic-features: loudness and pitch instability, rhythmic abilities, note attack precision, loudness consistency and pitch consistency. Healthy wind instrumentalist s normative acoustic data and feature set. Seven healthy wind instrumentalists followed the experimental protocol and generated a series of audio recordings, which formed a baseline dataset and following application of the software platform a reference output feature sets This data and feature set provide a comparison for data acquired from ED musicians. A comparative study between audio-based features extracted from ED and control musicians acoustic data. A freely available database of six ED subjects recorded during musical performance was analysed by the developed software platform. Inter-group comparisons revealed greater sound instability in notes played by ED than in those recorded from healthy musicians. Software analysis for… Advisors/Committee Members: Reilly, Richard.

Subjects/Keywords: Musician's Dystonia; Movement disorders; Embouchure Dystonia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

PEREZ DENIA, M. (2020). Objective and Quantitative acoustic-analysis of musicians dystonia. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93052

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

PEREZ DENIA, MARTA. “Objective and Quantitative acoustic-analysis of musicians dystonia.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93052.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

PEREZ DENIA, MARTA. “Objective and Quantitative acoustic-analysis of musicians dystonia.” 2020. Web. 02 Mar 2021.

Vancouver:

PEREZ DENIA M. Objective and Quantitative acoustic-analysis of musicians dystonia. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93052.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

PEREZ DENIA M. Objective and Quantitative acoustic-analysis of musicians dystonia. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93052

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Campbell, David Edward. What explains the crime/tort distinction? Developing and applying Razian theory.

Degree: School of Law. Discipline of Law, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93075

► This thesis is a work of legal theory within the discipline of philosophy of action and more particularly the field of practical reason theory. The… (more)

▼ This thesis is a work of legal theory within the discipline of philosophy of action and more particularly the field of practical reason theory. The thesis asks the question: What explains the crime/tort distinction? It adopts and develops Razian theory to provide an answer. The explanation proposed is that crime is fundamentally concerned with assessing the rightness of agency in light of relevant norms whereas tort is fundamentally concerned with assessing the conformity of agency with applicable norms. Joseph Raz identified as the most important branches of practical philosophy; value theory, normative theory and ascriptive theory. Value theory being centrally concerned with good, bad, better and worse; normative theory with ought, rules, duties; and ascriptive theory with attributing blame and responsibility. The thesis works through the lens of Razian theory and largely within the normative and ascriptive domains of this schema. The thesis contends that the Razian calculus of determining what is to be done by reference to the undefeated outcome of conflicting reasons of differing positional and internal weight does not fully explain or fit our assessments of instances where an agent s sound reasoning conflicts with the requirements of an applicable norm. Another distinction, noted but undeveloped by Raz, between acting reasonably and acting in a manner well-grounded in reason is adopted and developed, where the former is an assessment of the agency in light of subjectively bounded but objectively determined relevant norms and the latter an assessment of the conformance of agency with purely objectively discerned applicable norms. It is proposed this distinction provides a solution to this problem of incompleteness and it is argued also forms the basis of an explanation for the crime/tort distinction. The thesis adopts and develops John Gardner s understanding of wrongness as constituted by dissonance between guiding and explanatory reasons. It is argued that wrongness is in fact a species of reasonableness assessment while on the other hand duty breaches are a species of well-groundedness assessments. The thesis adopts a central case approach to argue that at the core of criminal blameworthiness assessments is wrongness, making it fundamentally a reasonableness assessment while at the core of tortious responsibility assessments is duty breach, making it fundamentally a well-groundedness assessment. The theory developed by this thesis is then tested through its application to cognate theoretical debates and against critiques of general theories, in order to assess whether or not the theory can provide a coherent and fitting set of answers to these ongoing debates. Advisors/Committee Members: Prendergast, David.

Subjects/Keywords: Raz; Crime/Tort; Legal Theory; PhD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Campbell, D. E. (2020). What explains the crime/tort distinction? Developing and applying Razian theory. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93075

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Campbell, David Edward. “What explains the crime/tort distinction? Developing and applying Razian theory.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93075.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Campbell, David Edward. “What explains the crime/tort distinction? Developing and applying Razian theory.” 2020. Web. 02 Mar 2021.

Vancouver:

Campbell DE. What explains the crime/tort distinction? Developing and applying Razian theory. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93075.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Campbell DE. What explains the crime/tort distinction? Developing and applying Razian theory. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93075

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. FREITAS DA SILVA VUCINIC, MARIA ISABEL. Jurassic evaporites and diapirism along the southern Tanzanian continental margin: Implications for petroleum exploration.

Degree: School of Natural Sciences. Discipline of Geology, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93097

► One of the key issues for petroleum exploration along the entire Tanzanian margin is the extent of evaporite deposition and its diapirism. This leads to… (more)

▼ One of the key issues for petroleum exploration along the entire Tanzanian margin is the extent of evaporite deposition and its diapirism. This leads to scenarios for the configuration and relative movement of conjugate fragments across East Africa. In Mandawa Basin, the separation from Africa provided restricted conditions for salt deposition in the Lower Jurassic, with the rise to continued deposition and sedimentation of anoxic marine shale and locally evaporites trigged by the evolution of the salt minibasin approximately in the Middle Jurassic. In this study, the methodological approach of combining geological and geophysical techniques has been addressed to characterise the types of salt, the lithostratigraphy, and seismic sequences of the geological framework by variations through time in stratigraphy (source rocks) and structural geometry (salt diapirs). The provided legacy containing 2D seismic lines, geophysical well logs, well data were used as input data to re-access the onshore Mandawa salt basin. The workflow involved in importing the dataset, performed a quality check of the 2D seismic lines seismic attribute analysis horizon and fault interpretation, structural modelling, and depth conversion from the final 3D geocellular model from time to depth. The identification of the lithological units has been carried out which helped to identify salt structures according to change in signal responses, lateral continuity, bedding sequences, and thickness surfaces. A well correlation in this thesis was performed resulting in seven zones defined in between the markers where four of them specifically may correlate to previous stratigraphic units proposed firstly by Shell in 1990 for the onshore Mandawa Basin: Mbuo Formation, Nondwa Formation, and Mtumbei Limestone Formation. This study observed different types of salt of marine evaporite diapirism present in Mandawa Basin: halite, anhydrite and gypsum. Results in this study further suggest the existence of sequences of halite in most of the wells, such as Mbuo-1, Mihambia-1, East Lika-1, Mita Gamma-1, Mbate-1 and Mandawa-7. Another evaporite type as anhydrite salt has been identified interbedded with claystones and sandstones sediments in Milhambia-1 and East-Lika-1 wells. The salt in Mandawa Basin has been interpreted in this work as mostly autochthonous building up from the Lower Jurassic, below the present-day shelf. In addition to the findings here, the appearance of an allochthonous detached salt sheet structure extending into the Lower Cretaceous strata in central Mandawa Basin suggests that the salt pillow originates from Upper Jurassic and with deposition during the Cretaceous. The use of 2D restoration technique revealed that the salt layer and the overlapping layers had tabular geometry prior to extension followed by a rise of a diapir by reactive bearing to the formation of a graben associated with the extension of sedimentary overload. Sequence stratigraphy analysis has also been carried out during this research according to the identification of… Advisors/Committee Members: Nicholas, Christopher.

Subjects/Keywords: Salt tectonics; Petroleum geology; Tanzania; East Africa; Geophysics; Mandawa Basin; 3D Modelling

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APA (6^th Edition):

FREITAS DA SILVA VUCINIC, M. I. (2020). Jurassic evaporites and diapirism along the southern Tanzanian continental margin: Implications for petroleum exploration. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93097

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

FREITAS DA SILVA VUCINIC, MARIA ISABEL. “Jurassic evaporites and diapirism along the southern Tanzanian continental margin: Implications for petroleum exploration.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93097.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

FREITAS DA SILVA VUCINIC, MARIA ISABEL. “Jurassic evaporites and diapirism along the southern Tanzanian continental margin: Implications for petroleum exploration.” 2020. Web. 02 Mar 2021.

Vancouver:

FREITAS DA SILVA VUCINIC MI. Jurassic evaporites and diapirism along the southern Tanzanian continental margin: Implications for petroleum exploration. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93097.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

FREITAS DA SILVA VUCINIC MI. Jurassic evaporites and diapirism along the southern Tanzanian continental margin: Implications for petroleum exploration. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93097

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. NEWMAN, JOSH QUEZADA. On the uses and disadvantages of history for Ireland : James Joyce and nationalist historiography.

Degree: School of English. Discipline of English, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93098

► Nationalism saw a tremendous rise in Ireland during the late-nineteenth and early-twentieth centuries, culminating in the Easter Rising and the formation of the Irish Free… (more)

▼ Nationalism saw a tremendous rise in Ireland during the late-nineteenth and early-twentieth centuries, culminating in the Easter Rising and the formation of the Irish Free State. James Joyce's reading and interpretation of historical texts and events before and up to his lifetime were inherently influenced by nationalism. The development of Irish nationalism in its various forms is critical to any comprehensive understanding of Joyce's engagement with history. Joyce was ultimately skeptical of nationalist interpretations of history, considering them skewed, inaccurate, and at times deleterious to Ireland. This skepticism aligned with his general wariness of nationalism itself. Although he was critical of the various strains of nationalism during his lifetime, his writings demonstrate both a reprimand and an interpolation, both intentional and unwitting, of nationalist historiography. The Citizen of the Cyclops episode in Ulysses exemplifies some of the worst aspects of Irish nationalism, yet he is just one of the several characters in Joyce's work who demonstrate a tainted understanding of Irish history. The Gaelic-Catholic sectarian cultural nationalism of the likes of Michael Cusack and David Patrick D. P. Moran, the optimistic political republican nationalism of Arthur Griffith, and the socialist nationalism of James Connolly and Roger Casement are just some of the strains of Irish nationalism prevalent in Joyce's time, yet they represent some of the most prominent manifestations that Joyce engages. Drawing from a number of historiographical and theoretical methodologies and analyzing the deluge of historical materials during this time, I interrogate these nationalist historiographies as evident in Joyce's work. The Great Famine, Laudabiliter, the 1798 Rebellion, the Austro-Hungarian Compromise of 1867, the Phoenix Park Murders, the Second Boer War, the Brehon laws, the Irish Revival, the Gaelic League, Zionism, and seventeenth-through-twentieth century inter-European migration are just some of the historical topics and events examined in my dissertation. Employing a broadly subaltern historiographical critique derived from the work of scholars such as David Lloyd and Seamus Deane, as well as engaging distinguished Joycean scholars such as Emer Nolan, James Fairhall, Andrew Gibson, Robert Spoo, and Anne Fogarty, this study examines the multifaceted and even frustrating historiography in Joyce's work, primarily though not exclusively Dubliners (1914), A Portrait of the Artist as a Young Man (1916), Ulysses (1922), and his various articles and lectures from his early life collected in Occasional, Critical, and Political Writing. Advisors/Committee Members: Slote, Samuel.

Subjects/Keywords: Nationalism; Historiography; Irish Revival; James Joyce; Arthur Griffith; D. P. Moran; Zionism; 1798 Rebellion; Semicolonialism; Socialism; Resurrection of Hungary; Laudabiliter; Irish Nationalism

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APA (6^th Edition):

NEWMAN, J. Q. (2020). On the uses and disadvantages of history for Ireland : James Joyce and nationalist historiography. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

NEWMAN, JOSH QUEZADA. “On the uses and disadvantages of history for Ireland : James Joyce and nationalist historiography.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

NEWMAN, JOSH QUEZADA. “On the uses and disadvantages of history for Ireland : James Joyce and nationalist historiography.” 2020. Web. 02 Mar 2021.

Vancouver:

NEWMAN JQ. On the uses and disadvantages of history for Ireland : James Joyce and nationalist historiography. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

NEWMAN JQ. On the uses and disadvantages of history for Ireland : James Joyce and nationalist historiography. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. WANG, QI. Work/Retirement, Family Relations, and Perceptions on the Pension Regime of Middle-aged Citizens in Urban China.

Degree: School of Social Work & Social Policy. Discipline of Social Studies, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93104

► Focusing on urban areas of contemporary China, this thesis interrogates the interactions between the pension and retirement policy and the pathways of middle-aged citizens to… (more)

Subjects/Keywords: pensions; retirement; family; China; Grounded Theory

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APA (6^th Edition):

WANG, Q. (2020). Work/Retirement, Family Relations, and Perceptions on the Pension Regime of Middle-aged Citizens in Urban China. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93104

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

WANG, QI. “Work/Retirement, Family Relations, and Perceptions on the Pension Regime of Middle-aged Citizens in Urban China.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93104.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

WANG, QI. “Work/Retirement, Family Relations, and Perceptions on the Pension Regime of Middle-aged Citizens in Urban China.” 2020. Web. 02 Mar 2021.

Vancouver:

WANG Q. Work/Retirement, Family Relations, and Perceptions on the Pension Regime of Middle-aged Citizens in Urban China. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93104.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

WANG Q. Work/Retirement, Family Relations, and Perceptions on the Pension Regime of Middle-aged Citizens in Urban China. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93104

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Ghanim, Magda. HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer.

Degree: School of Biochemistry & Immunology. Discipline of Biochemistry, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93149

► Oral and oesophageal cancers are aggressive tumours that are frequently diagnosed late, with high morbidity, mortality, and difficulties in surgical and therapeutic intervention. Novel imaging… (more)

▼ Oral and oesophageal cancers are aggressive tumours that are frequently diagnosed late, with high morbidity, mortality, and difficulties in surgical and therapeutic intervention. Novel imaging probes could assist in early diagnosis and alleviate treatment complications through demarking a clear margin for resection during surgery. A further need exists for effective and selective neoadjuvant therapies that reduce tumour size before surgery. This project addresses both issues by clarifying the mechanism of action of a class of natural anti-cancer protein-fatty acid complex agents derived from milk and by creating a synthetic polymer-fatty acid derivative as a probe for cancer cell identification. The novel probe was designed to be fluorescent and comprises natural component molecules found in milk and wheat. The probe s characteristics were investigated in SCC-9 cells - a squamous cell carcinoma of the tongue. The synthesised probe was shown to be non-toxic, and actively taken up, internalised, and expelled by cells by flow cytometry, confocal and multiphoton microscopy and fluorescence spectroscopy. An examination of the uptake mechanism revealed that the molecule is internalised via receptor-mediated endocytosis. The relevance of the probe for cancer cell identification was shown through inhibition of the molecule s uptake with a monoclonal antibody against the CD44 receptor, a key marker of cancer stem cell status, metastasis, and cancer progression. HAMLET (Human Alpha-lactalbumin Made Lethal to Tumour cells) and its bovine analogue BAMLET (Bovine Alpha-lactalbumin Made Lethal to Tumour cells) are protein-fatty acid complexes that display toxicity toward cancers of different origin, while most primary non-cancer cells remain resistant. We show that metabolism is important for their selective therapeutic potential against cancer cells and that BAMLET toxicity can be modulated through metabolic changes. Differentiation of SCC-9 cells significantly increased cellular resistance, whereas adaptation to culturing in galactose conditioned medium greatly sensitized the cells to BAMLET, and the effect was reversable by glucose addition. Metabolic and cellular uptake studies suggested a link between glycolytic activity, endocytic traffic, and BAMLET sensitivity. Through endocytosis inhibition studies, macropinocytosis was shown to be BAMLET s point of entry into SCC-9 cells. This discovery could lead to further developments resulting in improved fatty-acid containing complex based neoadjuvant therapeutics. Advisors/Committee Members: Kelly, Vincent.

Subjects/Keywords: HAMLET; neoadjuvant therapy; oral cancer; esophageal cancer; cancer imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ghanim, M. (2020). HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ghanim, Magda. “HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ghanim, Magda. “HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer.” 2020. Web. 02 Mar 2021.

Vancouver:

Ghanim M. HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93149.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ghanim M. HAMLET and synthetic derivatives as pre-operative agents in the treatment of oral and oesophageal cancer. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93149

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. STRAHAN, ORLA. Viral Hepatitis C Associated Neurocognitive Dysfunction in Ireland in the Direct Acting Antiviral (DAA) Era.

Degree: School of Psychology. Discipline of Psychology, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/93150

► Background & Aims: Neurocognitive dysfunction is common in the setting of cirrhosis and hepatic encephalopathy in individuals infected with the Hepatitis C Virus (HCV). However,… (more)

▼ Background & Aims: Neurocognitive dysfunction is common in the setting of cirrhosis and hepatic encephalopathy in individuals infected with the Hepatitis C Virus (HCV). However, neurocognitive dysfunction has also been described in non-cirrhotic, HCVRNA positive individuals. Although the underlying mechanism for HCV-associated neurocognitive dysfunction (HCV-AND) remains unclear, it is thought to be a result of direct viral invasion of brain tissues, or virally induced inflammatory cascades. Abnormalities have been reported in fronto-striatal structures, which are thought to be responsible for difficulties observed in memory, attention and executive functions. However, there is debate regarding the nature and reversibility of HCV-AND. Evidence of HCV-AND improvement has been described following viral eradication using interferon-based therapies, although these studies have produced inconclusive results. To date, no study has investigated the nature and reversibility of HCV-AND in a mono-infected, non-cirrhotic, HCVRNA positive sample using newly available interferon-free therapies (DAAs). Therefore, the aims of this thesis were to determine the profile and nature of HCV-AND (Study 1); to investigate the nature of select extra-hepatic features of HCV-AND (Study 2a); to control for confounding factors common in HCV study samples (Study 2b); and to determine the potential reversibility of HCV-AND following viral eradication using DAAs (Study 3). Methods: All individuals recruited into these studies had previously abnormal neuropsychological testing performance. For Study 1, HCV-AND was assessed in a sample of 135 mono-infected, non-cirrhotic, HCVRNA positive individuals using a detailed neuropsychological battery. These individuals also completed self-reported questionnaires to assess select extra-hepatic symptoms, forming the basis of Study 2a. Individuals were then randomised into a 6 month intervention where they received DAA treatment (DAA group) or routine care (Control group). Individuals were re-assessed in neuropsychological performance and self-reported extra-hepatic symptoms following their respective intervention (n = 96), which was investigated in Study 3. In addition, Study 2b investigated the potential differences in neuropsychological performance (using a brief cognitive screening test) and mood state between a chronic HCVRNA positive group and a HCVRNA negative group. The HCVRNA positive group were studied as part of a larger research project and for whom screening data were available (n = 709), and the HCVRNA negative group were a specially recruited sample of individuals who, following infection, spontaneously cleared the virus (n = 32). Results: Study 1 reported that 83% demonstrated difficulties in one or more cognitive domains, including memory (encoding and retrieval but not retention/storage), attention and executive functions, and performance was influenced by factors such as lower education and previous substance abuse. Study 2a reported low mood in 41-64% of the sample, fatigue 73%, and… Advisors/Committee Members: Dockree, Paul, Coen, Robert.

Subjects/Keywords: Hepatitis C Virus; Neurocognitive Dysfunction; DAA; Neuropsychological Assessment; Mood State; Fatigue; Health-Related Quality of Life

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

STRAHAN, O. (2020). Viral Hepatitis C Associated Neurocognitive Dysfunction in Ireland in the Direct Acting Antiviral (DAA) Era. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93150

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

STRAHAN, ORLA. “Viral Hepatitis C Associated Neurocognitive Dysfunction in Ireland in the Direct Acting Antiviral (DAA) Era.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/93150.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

STRAHAN, ORLA. “Viral Hepatitis C Associated Neurocognitive Dysfunction in Ireland in the Direct Acting Antiviral (DAA) Era.” 2020. Web. 02 Mar 2021.

Vancouver:

STRAHAN O. Viral Hepatitis C Associated Neurocognitive Dysfunction in Ireland in the Direct Acting Antiviral (DAA) Era. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/93150.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

STRAHAN O. Viral Hepatitis C Associated Neurocognitive Dysfunction in Ireland in the Direct Acting Antiviral (DAA) Era. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93150

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. MAHON, OLWYN. Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering.

Degree: School of Biochemistry & Immunology. Discipline of Biochemistry, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92807

► Early trauma, resulting in focal areas of cartilage damage with injury to the underlying subchondral bone (osteochondral damage) often progresses to arthritis. These so called… (more)

▼ Early trauma, resulting in focal areas of cartilage damage with injury to the underlying subchondral bone (osteochondral damage) often progresses to arthritis. These so called osteochondral defects (OCDs) can arise from an acute traumatic injury to the knee or an underlying disorder of the bone. If left untreated, localised OCDs can become widespread and often progress to more severe damage, as is the case in Osteoarthritis (OA). It is now widely accepted that cartilage damage in OA is associated with inflammation and a number of ?damage? or ?danger? associated molecules have been identified that contribute to this phenotype. They include hyaluronic acid fragments, basic calcium phosphate (BCP) crystals and members of the S100 family of proteins. As joint damage progresses, total joint replacement (TJR) is required to relieve pain and restore joint function, however TJRs themselves are associated with long-term complications such as periprosthetic osteolysis (PO) which is driven by implant-derived wear debris particles that are generated over time causing inflammation and eventual implant failure. With this in mind, efforts are underway to (i) improve the biocompatibility and durability of orthopaedic implants and (ii) to develop tissue engineering strategies that can repair early osteochondral damage, before OA progresses. The most promising approach is to develop biomaterial scaffolds that promote self-repair and regeneration of damaged tissue. However, as with traditional implant materials, tissue engineered constructs can also impact host immune responses and it has become increasingly apparent that engineering a pro-regenerative immune response following scaffold implantation is integral to functional tissue regeneration. This study aimed to investigate the direct effects of endogenous and exogenous calcium phosphate particulates in human macrophages. These particulates include OA-associated BCP crystals and hydroxyapatite (HA), which is commonly used as a coating for orthopaedic implants and bone tissue engineering applications. The data presented here demonstrates that BCP crystals drive pro-inflammatory M1 macrophage polarization and metabolic reprogramming, causing cells to derive energy from glycolysis rather than oxidative phosphorylation, a phenomenon that is emerging as a key regulator of macrophage phenotype. This study therefore, not only provides further insight into how OA-associated DAMPs impact on immune cell function, but also highlights metabolic reprogramming as a potential therapeutic target for calcium crystal-related arthropathies. This study also examined the specific signalling pathways activated by wear particles in primary human macrophages. As was the case for BCP crystals, HA and PMMA (i.e. bone cement) particles were found to drive M1 macrophage polarization and this was shown to be dependent on activation of the membrane proximal kinase, Spleen Tyrosine Kinase (Syk), in addition to members of the mitogen-activated protein kinase (MAPK) family of signalling molecules. Pre-treatment of… Advisors/Committee Members: Dunne, Aisling.

Subjects/Keywords: Tissue engineering; Osteoarthritis; Bone tissue

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

MAHON, O. (2020). Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92807

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

MAHON, OLWYN. “Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92807.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

MAHON, OLWYN. “Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering.” 2020. Web. 02 Mar 2021.

Vancouver:

MAHON O. Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92807.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

MAHON O. Characterisation of the immune response to calcium phosphate particulates; implications for osteoarthritis and bone tissue engineering. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92807

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. MEIGHAN, BRENDAN JAMES. 'The development of Irish identity: political aspiration and literary conceptions, 600-919.

Degree: School of Histories & Humanities. Discipline of History, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92829

► This thesis examines the development of an Irish identity in the early medieval period. It covers roughly three centuries, from 600 to 919, and it… (more)

Subjects/Keywords: Ireland; Identity; Early Medieval

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APA (6^th Edition):

MEIGHAN, B. J. (2020). 'The development of Irish identity: political aspiration and literary conceptions, 600-919. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

MEIGHAN, BRENDAN JAMES. “'The development of Irish identity: political aspiration and literary conceptions, 600-919.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

MEIGHAN, BRENDAN JAMES. “'The development of Irish identity: political aspiration and literary conceptions, 600-919.” 2020. Web. 02 Mar 2021.

Vancouver:

MEIGHAN BJ. 'The development of Irish identity: political aspiration and literary conceptions, 600-919. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

MEIGHAN BJ. 'The development of Irish identity: political aspiration and literary conceptions, 600-919. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Zaporojan, Lilia. A Follow up Study Evaluating the Effects of HIV Related Cognitive Impairment.

Degree: School of Medicine. Discipline of Clinical Medicine, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92839

► Study background: The introduction and availability of highly active antiretroviral therapy (HAART) led to an increased life expectancy among people living with HIV (PLWH) and… (more)

▼ Study background: The introduction and availability of highly active antiretroviral therapy (HAART) led to an increased life expectancy among people living with HIV (PLWH) and reduced the incidence of HIV associated dementia (HAD). However, milder forms of disease related cognitive impairment (CI), known as HIV associated neurocognitive disorders (HAND) remain frequent and validation of biomarkers of the disease course and prognosis is needed. This project involved follow-up studies of an Irish cohort of PLWH who were screened for HIV related CI between 2010 and 2013 (McNamara et al., 2014), to evaluate the changes in the brain associated with HAND assessed by a battery of neuropsychological tests and different neuroimaging techniques. Hypothesis: This work is centred on the hypothesis that HIV virus enters the central nervous system (CNS) with infected immune cells (macrophages) causing early inflammation evolving later into a neurodegenerative process from apoptosis and other programmed cell death mechanisms. This model would predict a slow steady cognitive and functional decline in patients with HIV. Aims: The primary aim of this study was to evaluate the natural course of HAND in the era of HAART by following an already well characterised cohort of PLWH with the use of a neuropsychology test battery and multimodal neuroimaging (MRI) data analysis. Additional sub-aims were to evaluate whether or not PLWH who also suffer from HIV related CI use hospital resources more intensively, and whether or not PLWH have a higher burden of other neurological conditions, such as seizures and epilepsy. Methods: A sub-cohort of 79 HIV+ patients who attend HIV services at St. James's Hospital (SJH) and who screened positive for CI and underwent detailed baseline assessments (McNamara et al., 2014) were followed between November 2014 and December 2016, with clinical, functional and a range of neuropsychological examinations (RBANS, ACE-r, MoCA, FAB) to evaluate for presumed cognitive function decline. To assess for progressive grey and white matter alteration at follow-up, a multimodal neuroimaging approach involving Volumetric Brain Morphometry (VBM) and Diffusion Tensor Imaging (DTI) was used in a subset of 42 HIV+ patients who also underwent neuroimaging data acquisition at baseline. To compare hospital services utilisation and costs in PLWH with and without CI, clinical and financial data was obtained from the SJH hospital's Patient Administration System (PAS), hospital electronic patient records (EPR) system, and financial department on a randomly selected subgroup of 200 of the original 604 participants screened for CI. The burden of seizures and epilepsy in the original cohort of 604 subjects was evaluated using the healthcare records (HCR) and EPR. Results: On neuropsychological follow-up, this cohort showed overall stability with only a minority of PLWH progressing to severe cognitive impairment. MRI showed marked widespread inflammatory / microstructural changes in the white matter at baseline with relative stability at… Advisors/Committee Members: Doherty, Colin.

Subjects/Keywords: HIV associated neurocognitive disorders; HAND; VBM and HIV associated neurocognitive disorders; DTI and HIV associated neurocognitive disorders; HIV associated neurocognitive disorders neuropsychological follow-up

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zaporojan, L. (2020). A Follow up Study Evaluating the Effects of HIV Related Cognitive Impairment. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zaporojan, Lilia. “A Follow up Study Evaluating the Effects of HIV Related Cognitive Impairment.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zaporojan, Lilia. “A Follow up Study Evaluating the Effects of HIV Related Cognitive Impairment.” 2020. Web. 02 Mar 2021.

Vancouver:

Zaporojan L. A Follow up Study Evaluating the Effects of HIV Related Cognitive Impairment. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zaporojan L. A Follow up Study Evaluating the Effects of HIV Related Cognitive Impairment. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. NICOARA, RALUCA-MARIA. Authoritarian diffusion at a distance? China's impact on levels of and on citizens' support for liberal-democracy in Sub-Saharan African states.

Degree: School of Social Sciences & Philosophy. Discipline of Political Science, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92751

► The recent emergence of authoritarian countries, such as China, as leading economic powers, increasingly engaged in the developing world, has coincided with a 'democratic recession'… (more)

▼ The recent emergence of authoritarian countries, such as China, as leading economic powers, increasingly engaged in the developing world, has coincided with a 'democratic recession' in certain developing countries. Are these two processes related? Is the rise of authoritarian powers leading to authoritarian diffusion in the developing world? These important questions can be studied from several angles, one of which is whether authoritarian diffusion is happening because of the increasing economic linkages between developing world and authoritarian powers. So far, the scholarship has focused on studying the impact of authoritarian regimes on neighbouring countries but it has not investigated whether, through economic links, they might be having influence beyond their own neighbours. China's increasing role in Sub-Saharan Africa provides an ideal setting to explore this issue as democratic and liberal institutions in these states have not yet been consolidated (Lynch and Crawford 2011) while China has different levels of engagement in different Sub-Saharan African countries (Mohan and Power 2008). This research tests the hypothesis that higher economic linkages with China might have negative impact on both levels of and attitudes towards democracy in African states. First, the hypothesis is investigated at individual level, by testing the demonstration effect of the Chinese financed projects, whose geolocated data is combined with the sub-national variation on citizens' attitudes toward liberal-democracy. Then, it tests the learning mechanism through an original survey-experiment conducted in Kenya, which is a typical African country. Last, the hypothesis is investigated at institutional level by using time-series data on levels of Chinese economic engagement and levels of liberal-democracy. Overall, this project contributes to our understanding of the diffusion of authoritarian norms and practices in the developing world by providing a first test of whether China's increasing presence in Sub-Saharan Africa is leading to changing levels and attitudes towards liberal democracy. Advisors/Committee Members: D'Arcy, Michelle.

Subjects/Keywords: democracy; diffusion; China; Africa; liberal-democracy; regime

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APA (6^th Edition):

NICOARA, R. (2020). Authoritarian diffusion at a distance? China's impact on levels of and on citizens' support for liberal-democracy in Sub-Saharan African states. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92751

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

NICOARA, RALUCA-MARIA. “Authoritarian diffusion at a distance? China's impact on levels of and on citizens' support for liberal-democracy in Sub-Saharan African states.” 2020. Thesis, Trinity College Dublin. Accessed March 02, 2021. http://hdl.handle.net/2262/92751.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

NICOARA, RALUCA-MARIA. “Authoritarian diffusion at a distance? China's impact on levels of and on citizens' support for liberal-democracy in Sub-Saharan African states.” 2020. Web. 02 Mar 2021.

Vancouver:

NICOARA R. Authoritarian diffusion at a distance? China's impact on levels of and on citizens' support for liberal-democracy in Sub-Saharan African states. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2262/92751.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

NICOARA R. Authoritarian diffusion at a distance? China's impact on levels of and on citizens' support for liberal-democracy in Sub-Saharan African states. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92751

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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