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You searched for publisher:("Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University"). Showing records 1 – 27 of 27 total matches.

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1. Ramos, Ornélia Hermelinda. The role of the interleukin 12 family in atherosclerosis.

Degree: 2014, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 The main underlying mechanism resulting in cardiovascular complications is the formation of atherosclerotic lesions in arteries. The progression of the lesion is hallmarked by a… (more)

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APA (6th Edition):

Ramos, O. H. (2014). The role of the interleukin 12 family in atherosclerosis. (Doctoral Dissertation). Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/23363

Chicago Manual of Style (16th Edition):

Ramos, Ornélia Hermelinda. “The role of the interleukin 12 family in atherosclerosis.” 2014. Doctoral Dissertation, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/23363.

MLA Handbook (7th Edition):

Ramos, Ornélia Hermelinda. “The role of the interleukin 12 family in atherosclerosis.” 2014. Web. 06 Aug 2020.

Vancouver:

Ramos OH. The role of the interleukin 12 family in atherosclerosis. [Internet] [Doctoral dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/23363.

Council of Science Editors:

Ramos OH. The role of the interleukin 12 family in atherosclerosis. [Doctoral Dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/23363

2. Foks, Amanda C. Regulation of immune responses in atherosclerosis.

Degree: 2013, Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Atherosclerose wordt veroorzaakt door een combinatie van verhoogde cholesterolniveaus en een chronische ontstekingsreactie. Deze ontstekingsreactie is het gevolg van een verstoorde balans tussen slechte, agressieve… (more)

Subjects/Keywords: Atherosclerosis; Immune system; Immunology; T cells; Costimulation; Coinhibition; Regulatory T cells; Atherosclerosis; Immune system; Immunology; T cells; Costimulation; Coinhibition; Regulatory T cells

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APA (6th Edition):

Foks, A. C. (2013). Regulation of immune responses in atherosclerosis. (Doctoral Dissertation). Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/20933

Chicago Manual of Style (16th Edition):

Foks, Amanda C. “Regulation of immune responses in atherosclerosis.” 2013. Doctoral Dissertation, Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/20933.

MLA Handbook (7th Edition):

Foks, Amanda C. “Regulation of immune responses in atherosclerosis.” 2013. Web. 06 Aug 2020.

Vancouver:

Foks AC. Regulation of immune responses in atherosclerosis. [Internet] [Doctoral dissertation]. Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/20933.

Council of Science Editors:

Foks AC. Regulation of immune responses in atherosclerosis. [Doctoral Dissertation]. Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/20933

3. Diepstraten, Jeroen. The influence of morbid obesity on the pharmacokinetics and pharmacodynamics of drugs in adolescents and adults: focus on propofol and nadroparin.

Degree: 2013, Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 For most commonly used drugs in morbidly obese patients evidence based dosing guidelines are not available. Therefore, current dosing is based on experience of the… (more)

Subjects/Keywords: Drug dosing; Low-molecular-weight heparines; Nadroparin; Obesity; Pharmacodynamics; Pharmacokinetics; Propofol; Drug dosing; Low-molecular-weight heparines; Nadroparin; Obesity; Pharmacodynamics; Pharmacokinetics; Propofol

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APA (6th Edition):

Diepstraten, J. (2013). The influence of morbid obesity on the pharmacokinetics and pharmacodynamics of drugs in adolescents and adults: focus on propofol and nadroparin. (Doctoral Dissertation). Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/20959

Chicago Manual of Style (16th Edition):

Diepstraten, Jeroen. “The influence of morbid obesity on the pharmacokinetics and pharmacodynamics of drugs in adolescents and adults: focus on propofol and nadroparin.” 2013. Doctoral Dissertation, Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/20959.

MLA Handbook (7th Edition):

Diepstraten, Jeroen. “The influence of morbid obesity on the pharmacokinetics and pharmacodynamics of drugs in adolescents and adults: focus on propofol and nadroparin.” 2013. Web. 06 Aug 2020.

Vancouver:

Diepstraten J. The influence of morbid obesity on the pharmacokinetics and pharmacodynamics of drugs in adolescents and adults: focus on propofol and nadroparin. [Internet] [Doctoral dissertation]. Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/20959.

Council of Science Editors:

Diepstraten J. The influence of morbid obesity on the pharmacokinetics and pharmacodynamics of drugs in adolescents and adults: focus on propofol and nadroparin. [Doctoral Dissertation]. Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/20959

4. Smeden, Jeroen van. A breached barrier: analysis of stratum corneum lipids and their role in eczematous patients.

Degree: 2013, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 The stratum corneum is the outermost layer of the skin, and acts as the primary barrier against penetration of pathogens, allergens and other exogenous substances… (more)

Subjects/Keywords: Stratum corneum lipids; Ceramides; Free fatty acids; Lipid organization; Atopic Eczema; Human skin equivalents; Netherton Syndrome; Liquid chromatography / Mass spectrometry; Skin barrier function; Stratum corneum lipids; Ceramides; Free fatty acids; Lipid organization; Atopic Eczema; Human skin equivalents; Netherton Syndrome; Liquid chromatography / Mass spectrometry; Skin barrier function

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APA (6th Edition):

Smeden, J. v. (2013). A breached barrier: analysis of stratum corneum lipids and their role in eczematous patients. (Doctoral Dissertation). Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/20998

Chicago Manual of Style (16th Edition):

Smeden, Jeroen van. “A breached barrier: analysis of stratum corneum lipids and their role in eczematous patients.” 2013. Doctoral Dissertation, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/20998.

MLA Handbook (7th Edition):

Smeden, Jeroen van. “A breached barrier: analysis of stratum corneum lipids and their role in eczematous patients.” 2013. Web. 06 Aug 2020.

Vancouver:

Smeden Jv. A breached barrier: analysis of stratum corneum lipids and their role in eczematous patients. [Internet] [Doctoral dissertation]. Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/20998.

Council of Science Editors:

Smeden Jv. A breached barrier: analysis of stratum corneum lipids and their role in eczematous patients. [Doctoral Dissertation]. Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/20998

5. Wang, Chenguang. Novel approach to characterize developmental changes in pharmacokinetics across the human lifespan: application to the prediction of clearance in children.

Degree: 2013, Division of Pharmacolgy, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

This book focuses on novel approach to characterize developmental changes in pharmacokinetics across human lifespan with the up-to-date Nonlinear Mixed Effect Modeling techniques.

Subjects/Keywords: Pharmacometrics; Allometric scaling; NONMEM; Paediatrics; Pharmacokinetics; Pharmacometrics; Allometric scaling; NONMEM; Paediatrics; Pharmacokinetics

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APA (6th Edition):

Wang, C. (2013). Novel approach to characterize developmental changes in pharmacokinetics across the human lifespan: application to the prediction of clearance in children. (Doctoral Dissertation). Division of Pharmacolgy, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/22108

Chicago Manual of Style (16th Edition):

Wang, Chenguang. “Novel approach to characterize developmental changes in pharmacokinetics across the human lifespan: application to the prediction of clearance in children.” 2013. Doctoral Dissertation, Division of Pharmacolgy, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/22108.

MLA Handbook (7th Edition):

Wang, Chenguang. “Novel approach to characterize developmental changes in pharmacokinetics across the human lifespan: application to the prediction of clearance in children.” 2013. Web. 06 Aug 2020.

Vancouver:

Wang C. Novel approach to characterize developmental changes in pharmacokinetics across the human lifespan: application to the prediction of clearance in children. [Internet] [Doctoral dissertation]. Division of Pharmacolgy, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/22108.

Council of Science Editors:

Wang C. Novel approach to characterize developmental changes in pharmacokinetics across the human lifespan: application to the prediction of clearance in children. [Doctoral Dissertation]. Division of Pharmacolgy, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/22108

6. Taneja, Amit. PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement.

Degree: 2013, Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Chronic pain is a significant health problem that greatly impacts the quality of life of individual patients and imparts high costs to society. Despite intense… (more)

Subjects/Keywords: PKPD; Relationships; Analgesic; Drug development; Target; Engagement; Prediction; Neuropathic pain; Chronic pain; Biomarkers; Translation; PKPD; Relationships; Analgesic; Drug development; Target; Engagement; Prediction; Neuropathic pain; Chronic pain; Biomarkers; Translation

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APA (6th Edition):

Taneja, A. (2013). PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement. (Doctoral Dissertation). Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/22300

Chicago Manual of Style (16th Edition):

Taneja, Amit. “PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement.” 2013. Doctoral Dissertation, Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/22300.

MLA Handbook (7th Edition):

Taneja, Amit. “PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement.” 2013. Web. 06 Aug 2020.

Vancouver:

Taneja A. PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement. [Internet] [Doctoral dissertation]. Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/22300.

Council of Science Editors:

Taneja A. PKPD relationships and dose rationale in analgesic drug development: towards the prediction of target engagement. [Doctoral Dissertation]. Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/22300

7. Piana, Chiara. Adherence to antiretroviral combination therapy in children: what a difference half a day makes...

Degree: 2013, Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Adherence to antiretroviral combination therapy in children. What a difference half a day makes…” has explored the opportunities to support evidence generation and extrapolation across… (more)

Subjects/Keywords: Antiretroviral drugs; Paediatric populations; Drug combinations; Model-based research; Covariate analysis; Predictive pharmacokinetic models; Clinical trial simulations; Adherence to therapy; Forgiveness of non-adherence; Antiretroviral drugs; Paediatric populations; Drug combinations; Model-based research; Covariate analysis; Predictive pharmacokinetic models; Clinical trial simulations; Adherence to therapy; Forgiveness of non-adherence

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APA (6th Edition):

Piana, C. (2013). Adherence to antiretroviral combination therapy in children: what a difference half a day makes... (Doctoral Dissertation). Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/22077

Chicago Manual of Style (16th Edition):

Piana, Chiara. “Adherence to antiretroviral combination therapy in children: what a difference half a day makes...” 2013. Doctoral Dissertation, Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/22077.

MLA Handbook (7th Edition):

Piana, Chiara. “Adherence to antiretroviral combination therapy in children: what a difference half a day makes...” 2013. Web. 06 Aug 2020.

Vancouver:

Piana C. Adherence to antiretroviral combination therapy in children: what a difference half a day makes... [Internet] [Doctoral dissertation]. Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/22077.

Council of Science Editors:

Piana C. Adherence to antiretroviral combination therapy in children: what a difference half a day makes... [Doctoral Dissertation]. Division of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/22077

8. Di, Zi. Development of automatic image analysis methods for high-throughput and high-content screening.

Degree: 2013, Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 This thesis focuses on the development of image analysis methods for ultra-high content analysis of high-throughput screens where cellular phenotype responses to various genetic or… (more)

Subjects/Keywords: High-throughput screening; Ultra high-content analysis; Image analysis; Multi-parametric phenotype profiling; High-throughput screening; Ultra high-content analysis; Image analysis; Multi-parametric phenotype profiling

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APA (6th Edition):

Di, Z. (2013). Development of automatic image analysis methods for high-throughput and high-content screening. (Doctoral Dissertation). Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/22833

Chicago Manual of Style (16th Edition):

Di, Zi. “Development of automatic image analysis methods for high-throughput and high-content screening.” 2013. Doctoral Dissertation, Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/22833.

MLA Handbook (7th Edition):

Di, Zi. “Development of automatic image analysis methods for high-throughput and high-content screening.” 2013. Web. 06 Aug 2020.

Vancouver:

Di Z. Development of automatic image analysis methods for high-throughput and high-content screening. [Internet] [Doctoral dissertation]. Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/22833.

Council of Science Editors:

Di Z. Development of automatic image analysis methods for high-throughput and high-content screening. [Doctoral Dissertation]. Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/22833

9. De Cock, Roosmarijn Frieda Wilfried. Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children.

Degree: 2014, Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Renal clearance is responsible for the elimination of a large number of water-soluble drugs and metabolites and is therefore of large importance when characterizing the… (more)

Subjects/Keywords: Renal function; Antibiotics; Glomerular filtration; Developmental changes; Pharmacokinetics; Neonates; Renal function; Antibiotics; Glomerular filtration; Developmental changes; Pharmacokinetics; Neonates

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APA (6th Edition):

De Cock, R. F. W. (2014). Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children. (Doctoral Dissertation). Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/25714

Chicago Manual of Style (16th Edition):

De Cock, Roosmarijn Frieda Wilfried. “Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children.” 2014. Doctoral Dissertation, Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/25714.

MLA Handbook (7th Edition):

De Cock, Roosmarijn Frieda Wilfried. “Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children.” 2014. Web. 06 Aug 2020.

Vancouver:

De Cock RFW. Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children. [Internet] [Doctoral dissertation]. Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/25714.

Council of Science Editors:

De Cock RFW. Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children. [Doctoral Dissertation]. Department of Pharmacology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/25714

10. Kloet, Frans Meindert van der. Quantification in untargeted mass spectrometry-based metabolomics.

Degree: 2014, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 The aim of this thesis was to develop concepts and methods to extract qualitative and quantitative information about metabolites from untargeted mass spectrometric data of… (more)

Subjects/Keywords: Metabolomics; Quantitation; High resolution mass spectrometry; Automated Integration; Untargeted; Metabolomics; Quantitation; High resolution mass spectrometry; Automated Integration; Untargeted

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APA (6th Edition):

Kloet, F. M. v. d. (2014). Quantification in untargeted mass spectrometry-based metabolomics. (Doctoral Dissertation). Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/25808

Chicago Manual of Style (16th Edition):

Kloet, Frans Meindert van der. “Quantification in untargeted mass spectrometry-based metabolomics.” 2014. Doctoral Dissertation, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/25808.

MLA Handbook (7th Edition):

Kloet, Frans Meindert van der. “Quantification in untargeted mass spectrometry-based metabolomics.” 2014. Web. 06 Aug 2020.

Vancouver:

Kloet FMvd. Quantification in untargeted mass spectrometry-based metabolomics. [Internet] [Doctoral dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/25808.

Council of Science Editors:

Kloet FMvd. Quantification in untargeted mass spectrometry-based metabolomics. [Doctoral Dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/25808

11. Medina Rodriguez, Indira A. Modulation of leukocyte homeostasis in atherosclerosis.

Degree: 2014, Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Many of the recognition molecules and mechanisms involved in immune responses have no bias towards external stimuli, but also sense and respond to pathological and… (more)

Subjects/Keywords: Atherosclerosis; Apoptosis; Migration; Diapedesis; Differentiation; Extravasation; Intravasation; Hematopoieisis; Macrophage; Chemotaxis; Atherosclerosis; Apoptosis; Migration; Diapedesis; Differentiation; Extravasation; Intravasation; Hematopoieisis; Macrophage; Chemotaxis

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APA (6th Edition):

Medina Rodriguez, I. A. (2014). Modulation of leukocyte homeostasis in atherosclerosis. (Doctoral Dissertation). Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/25765

Chicago Manual of Style (16th Edition):

Medina Rodriguez, Indira A. “Modulation of leukocyte homeostasis in atherosclerosis.” 2014. Doctoral Dissertation, Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/25765.

MLA Handbook (7th Edition):

Medina Rodriguez, Indira A. “Modulation of leukocyte homeostasis in atherosclerosis.” 2014. Web. 06 Aug 2020.

Vancouver:

Medina Rodriguez IA. Modulation of leukocyte homeostasis in atherosclerosis. [Internet] [Doctoral dissertation]. Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/25765.

Council of Science Editors:

Medina Rodriguez IA. Modulation of leukocyte homeostasis in atherosclerosis. [Doctoral Dissertation]. Department of Biopharmaceutics, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/25765

12. Ramaiahgari, Sreenivasa Chakravarthy. Advanced in vitro models for studying drug induced toxicity.

Degree: 2014, Department of Toxicology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Bringing safe medicines to the market has remained a major challenge to the pharmaceutical industry. Recent years have seen increased drug attrition rates due to… (more)

Subjects/Keywords: Alternative models; 3D spheroid culture; CYP450 enzymes; Drug induced liver injury; Alternative models; 3D spheroid culture; CYP450 enzymes; Drug induced liver injury

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APA (6th Edition):

Ramaiahgari, S. C. (2014). Advanced in vitro models for studying drug induced toxicity. (Doctoral Dissertation). Department of Toxicology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/25852

Chicago Manual of Style (16th Edition):

Ramaiahgari, Sreenivasa Chakravarthy. “Advanced in vitro models for studying drug induced toxicity.” 2014. Doctoral Dissertation, Department of Toxicology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/25852.

MLA Handbook (7th Edition):

Ramaiahgari, Sreenivasa Chakravarthy. “Advanced in vitro models for studying drug induced toxicity.” 2014. Web. 06 Aug 2020.

Vancouver:

Ramaiahgari SC. Advanced in vitro models for studying drug induced toxicity. [Internet] [Doctoral dissertation]. Department of Toxicology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/25852.

Council of Science Editors:

Ramaiahgari SC. Advanced in vitro models for studying drug induced toxicity. [Doctoral Dissertation]. Department of Toxicology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/25852

13. Guo, Dong. Drug-target residence time: a case for the adenosine A1 and A2A receptors.

Degree: 2014, Department of Medical Chemistry, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Ligand-receptor binding kinetics is increasingly recognized to play a pivotal role in the early phase of drug design and discovery. In this thesis ligand-receptor binding… (more)

Subjects/Keywords: Binding kinetics; Residence time; GPCR; Adenosine receptor; Kinetic assay; Binding kinetics; Residence time; GPCR; Adenosine receptor; Kinetic assay

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APA (6th Edition):

Guo, D. (2014). Drug-target residence time: a case for the adenosine A1 and A2A receptors. (Doctoral Dissertation). Department of Medical Chemistry, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/26833

Chicago Manual of Style (16th Edition):

Guo, Dong. “Drug-target residence time: a case for the adenosine A1 and A2A receptors.” 2014. Doctoral Dissertation, Department of Medical Chemistry, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/26833.

MLA Handbook (7th Edition):

Guo, Dong. “Drug-target residence time: a case for the adenosine A1 and A2A receptors.” 2014. Web. 06 Aug 2020.

Vancouver:

Guo D. Drug-target residence time: a case for the adenosine A1 and A2A receptors. [Internet] [Doctoral dissertation]. Department of Medical Chemistry, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/26833.

Council of Science Editors:

Guo D. Drug-target residence time: a case for the adenosine A1 and A2A receptors. [Doctoral Dissertation]. Department of Medical Chemistry, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/26833

14. Rojas-Chertó, Miquel. Towards automated identification of metabolites using mass spectral trees.

Degree: 2014, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 The detailed description of the chemical compounds present in organisms, organs/tissues, biofluids and cells is the key to understand the complexity of biological systems. The… (more)

Subjects/Keywords: Metabolomics; Metabolites; Multistage mass spectrometry; Databases; Metabolomics; Metabolites; Multistage mass spectrometry; Databases

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APA (6th Edition):

Rojas-Chertó, M. (2014). Towards automated identification of metabolites using mass spectral trees. (Doctoral Dissertation). Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/26892

Chicago Manual of Style (16th Edition):

Rojas-Chertó, Miquel. “Towards automated identification of metabolites using mass spectral trees.” 2014. Doctoral Dissertation, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/26892.

MLA Handbook (7th Edition):

Rojas-Chertó, Miquel. “Towards automated identification of metabolites using mass spectral trees.” 2014. Web. 06 Aug 2020.

Vancouver:

Rojas-Chertó M. Towards automated identification of metabolites using mass spectral trees. [Internet] [Doctoral dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/26892.

Council of Science Editors:

Rojas-Chertó M. Towards automated identification of metabolites using mass spectral trees. [Doctoral Dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/26892

15. Snelder, Nelleke. Towards predictive cardiovascular safety: a systems pharmacology approach.

Degree: 2014, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 Cardiovascular safety issues related to changes in blood pressure, arise frequently in drug development. In the thesis “Towards predictive cardiovascular safety – a systems pharmacology… (more)

Subjects/Keywords: Blood pressure; Heart rate; Cardiovascular; Population approach; Mechanism-based; Systems pharmacology; Blood pressure; Heart rate; Cardiovascular; Population approach; Mechanism-based; Systems pharmacology

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APA (6th Edition):

Snelder, N. (2014). Towards predictive cardiovascular safety: a systems pharmacology approach. (Doctoral Dissertation). Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/26945

Chicago Manual of Style (16th Edition):

Snelder, Nelleke. “Towards predictive cardiovascular safety: a systems pharmacology approach.” 2014. Doctoral Dissertation, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/26945.

MLA Handbook (7th Edition):

Snelder, Nelleke. “Towards predictive cardiovascular safety: a systems pharmacology approach.” 2014. Web. 06 Aug 2020.

Vancouver:

Snelder N. Towards predictive cardiovascular safety: a systems pharmacology approach. [Internet] [Doctoral dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/26945.

Council of Science Editors:

Snelder N. Towards predictive cardiovascular safety: a systems pharmacology approach. [Doctoral Dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/26945

16. Peironcely Miguel, Julio Eduardo. Automated de novo metabolite identification with mass spectrometry and cheminformatics.

Degree: 2014, Department of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 In this thesis new algorithms and methods that enable the de novo identification of metabolites have been developed. The aim was to find methods to… (more)

Subjects/Keywords: Metabolomics; Metabolite identification; Structure elucidation; Structure generation; Cheminformatics; Machine learning; Metabolomics; Metabolite identification; Structure elucidation; Structure generation; Cheminformatics; Machine learning

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APA (6th Edition):

Peironcely Miguel, J. E. (2014). Automated de novo metabolite identification with mass spectrometry and cheminformatics. (Doctoral Dissertation). Department of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/28508

Chicago Manual of Style (16th Edition):

Peironcely Miguel, Julio Eduardo. “Automated de novo metabolite identification with mass spectrometry and cheminformatics.” 2014. Doctoral Dissertation, Department of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/28508.

MLA Handbook (7th Edition):

Peironcely Miguel, Julio Eduardo. “Automated de novo metabolite identification with mass spectrometry and cheminformatics.” 2014. Web. 06 Aug 2020.

Vancouver:

Peironcely Miguel JE. Automated de novo metabolite identification with mass spectrometry and cheminformatics. [Internet] [Doctoral dissertation]. Department of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/28508.

Council of Science Editors:

Peironcely Miguel JE. Automated de novo metabolite identification with mass spectrometry and cheminformatics. [Doctoral Dissertation]. Department of Analytical Biosciences, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/28508

17. Raterink, Robert-Jan. High-throughput profiling of small molecules using mass spectrometry.

Degree: 2014, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 With the persistent efforts to improve healthcare while the costs are ever-increasing, there is a growing demand for healthcare innovations including faster and cheaper analytical… (more)

Subjects/Keywords: Sample pretreatment; Micro-liquid-liquid-extraction; Electroextraction; Microsampling; Metabolomics; Nanoelectrospray; Zebrafish; Bioanalysis; Sample pretreatment; Micro-liquid-liquid-extraction; Electroextraction; Microsampling; Metabolomics; Nanoelectrospray; Zebrafish; Bioanalysis

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APA (6th Edition):

Raterink, R. (2014). High-throughput profiling of small molecules using mass spectrometry. (Doctoral Dissertation). Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/28970

Chicago Manual of Style (16th Edition):

Raterink, Robert-Jan. “High-throughput profiling of small molecules using mass spectrometry.” 2014. Doctoral Dissertation, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/28970.

MLA Handbook (7th Edition):

Raterink, Robert-Jan. “High-throughput profiling of small molecules using mass spectrometry.” 2014. Web. 06 Aug 2020.

Vancouver:

Raterink R. High-throughput profiling of small molecules using mass spectrometry. [Internet] [Doctoral dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/28970.

Council of Science Editors:

Raterink R. High-throughput profiling of small molecules using mass spectrometry. [Doctoral Dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/28970

18. Vilums, Maris. Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists.

Degree: 2014, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 This thesis focuses on a new approach in drug discovery, the so-called drug-target residence time. Next to more traditional drug discovery efforts, which are based… (more)

Subjects/Keywords: Structure-Kinetics Relationships; Long Residence Time; CCR2 antagonists; Indane; Inflammatory diseases; Structure-Kinetics Relationships; Long Residence Time; CCR2 antagonists; Indane; Inflammatory diseases

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APA (6th Edition):

Vilums, M. (2014). Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists. (Doctoral Dissertation). Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/29811

Chicago Manual of Style (16th Edition):

Vilums, Maris. “Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists.” 2014. Doctoral Dissertation, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/29811.

MLA Handbook (7th Edition):

Vilums, Maris. “Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists.” 2014. Web. 06 Aug 2020.

Vancouver:

Vilums M. Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists. [Internet] [Doctoral dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/29811.

Council of Science Editors:

Vilums M. Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists. [Doctoral Dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/29811

19. Wezel, Anouk. Innate immune modulation in atherosclerosis and vascular.

Degree: 2014, Biopharmacy, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Atherosclerosis is a chronic inflammatory disease, consisting of the buildup of lipids in the vessel wall. Advanced lesions may become unstable and rupture, leading to… (more)

Subjects/Keywords: Atherosclerosis; Cardiovascular disease; Innate immune system; Atherosclerosis; Cardiovascular disease; Innate immune system

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APA (6th Edition):

Wezel, A. (2014). Innate immune modulation in atherosclerosis and vascular. (Doctoral Dissertation). Biopharmacy, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/29988

Chicago Manual of Style (16th Edition):

Wezel, Anouk. “Innate immune modulation in atherosclerosis and vascular.” 2014. Doctoral Dissertation, Biopharmacy, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/29988.

MLA Handbook (7th Edition):

Wezel, Anouk. “Innate immune modulation in atherosclerosis and vascular.” 2014. Web. 06 Aug 2020.

Vancouver:

Wezel A. Innate immune modulation in atherosclerosis and vascular. [Internet] [Doctoral dissertation]. Biopharmacy, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/29988.

Council of Science Editors:

Wezel A. Innate immune modulation in atherosclerosis and vascular. [Doctoral Dissertation]. Biopharmacy, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/29988

20. Stringer, Frances. Pharmacogenomics in drug development: implementation and application of PKPD model based approaches.

Degree: 2015, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are… (more)

Subjects/Keywords: Clinical pharmacology; Drug development; Pharmacogenetics; Diabetes; Genotype; Population approach; NONMEM; Clinical pharmacology; Drug development; Pharmacogenetics; Diabetes; Genotype; Population approach; NONMEM

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APA (6th Edition):

Stringer, F. (2015). Pharmacogenomics in drug development: implementation and application of PKPD model based approaches. (Doctoral Dissertation). Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/31601

Chicago Manual of Style (16th Edition):

Stringer, Frances. “Pharmacogenomics in drug development: implementation and application of PKPD model based approaches.” 2015. Doctoral Dissertation, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/31601.

MLA Handbook (7th Edition):

Stringer, Frances. “Pharmacogenomics in drug development: implementation and application of PKPD model based approaches.” 2015. Web. 06 Aug 2020.

Vancouver:

Stringer F. Pharmacogenomics in drug development: implementation and application of PKPD model based approaches. [Internet] [Doctoral dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2015. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/31601.

Council of Science Editors:

Stringer F. Pharmacogenomics in drug development: implementation and application of PKPD model based approaches. [Doctoral Dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2015. Available from: http://hdl.handle.net/1887/31601

21. Balcıoğlu, Hayri Emrah. Role of integrin adhesions in cellular mechanotransduction.

Degree: 2016, Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 Cells receive mechanical cues from the surrounding extracellular matrix (ECM). This has a strong impact on physiology and pathology in a wide range of biological… (more)

Subjects/Keywords: Cell-matrix adhesions; Integrins; Mechanotransduction; Mechanosensing; Cellular forces; Metastasis; Cancer progression; Cell-matrix adhesions; Integrins; Mechanotransduction; Mechanosensing; Cellular forces; Metastasis; Cancer progression

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APA (6th Edition):

Balcıoğlu, H. E. (2016). Role of integrin adhesions in cellular mechanotransduction. (Doctoral Dissertation). Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/38405

Chicago Manual of Style (16th Edition):

Balcıoğlu, Hayri Emrah. “Role of integrin adhesions in cellular mechanotransduction.” 2016. Doctoral Dissertation, Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/38405.

MLA Handbook (7th Edition):

Balcıoğlu, Hayri Emrah. “Role of integrin adhesions in cellular mechanotransduction.” 2016. Web. 06 Aug 2020.

Vancouver:

Balcıoğlu HE. Role of integrin adhesions in cellular mechanotransduction. [Internet] [Doctoral dissertation]. Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2016. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/38405.

Council of Science Editors:

Balcıoğlu HE. Role of integrin adhesions in cellular mechanotransduction. [Doctoral Dissertation]. Department of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2016. Available from: http://hdl.handle.net/1887/38405

22. Janssens, Michelle. Atopic eczema: the role of stratum corneum lipids in the skin barrier.

Degree: 2013, Division of Drug Delivery Technology at the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 The skin barrier function strongly relies on the outermost layer of the skin, the stratum corneum (SC), which consists of dead corneocytes embedded in a… (more)

Subjects/Keywords: Atopic eczema; Lipid composition; Lipid organization; Skin barrier function; Stratum corneum; Atopic eczema; Lipid composition; Lipid organization; Skin barrier function; Stratum corneum

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APA (6th Edition):

Janssens, M. (2013). Atopic eczema: the role of stratum corneum lipids in the skin barrier. (Doctoral Dissertation). Division of Drug Delivery Technology at the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/20911

Chicago Manual of Style (16th Edition):

Janssens, Michelle. “Atopic eczema: the role of stratum corneum lipids in the skin barrier.” 2013. Doctoral Dissertation, Division of Drug Delivery Technology at the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/20911.

MLA Handbook (7th Edition):

Janssens, Michelle. “Atopic eczema: the role of stratum corneum lipids in the skin barrier.” 2013. Web. 06 Aug 2020.

Vancouver:

Janssens M. Atopic eczema: the role of stratum corneum lipids in the skin barrier. [Internet] [Doctoral dissertation]. Division of Drug Delivery Technology at the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/20911.

Council of Science Editors:

Janssens M. Atopic eczema: the role of stratum corneum lipids in the skin barrier. [Doctoral Dissertation]. Division of Drug Delivery Technology at the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/20911

23. Torosantucci, Riccardo. Oxidation, aggregation and immunogenicity of therapeutic proteins.

Degree: 2013, Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 The aim of the research described in this thesis is to study the chemical mechanisms responsible for protein aggregation induced by metal catalyzed oxidation and… (more)

Subjects/Keywords: Therapeutic proteins; Metal catalyzed oxidation; Anti-oxidant; PEGylation; Immunogenicity; DOPA; Mass spectrometry; Therapeutic proteins; Metal catalyzed oxidation; Anti-oxidant; PEGylation; Immunogenicity; DOPA; Mass spectrometry

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APA (6th Edition):

Torosantucci, R. (2013). Oxidation, aggregation and immunogenicity of therapeutic proteins. (Doctoral Dissertation). Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/21762

Chicago Manual of Style (16th Edition):

Torosantucci, Riccardo. “Oxidation, aggregation and immunogenicity of therapeutic proteins.” 2013. Doctoral Dissertation, Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/21762.

MLA Handbook (7th Edition):

Torosantucci, Riccardo. “Oxidation, aggregation and immunogenicity of therapeutic proteins.” 2013. Web. 06 Aug 2020.

Vancouver:

Torosantucci R. Oxidation, aggregation and immunogenicity of therapeutic proteins. [Internet] [Doctoral dissertation]. Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/21762.

Council of Science Editors:

Torosantucci R. Oxidation, aggregation and immunogenicity of therapeutic proteins. [Doctoral Dissertation]. Department of Drug Delivery Technology, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2013. Available from: http://hdl.handle.net/1887/21762

24. Westerhout, Joost. Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution.

Degree: 2014, Division of Pharmacology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 In the development of drugs for the treatment of central nervous system (CNS) disorders, the prediction of human CNS drug action is a big challenge.… (more)

Subjects/Keywords: Pharmacokinetics; Blood-brain barrier; Systems-based pharmacokinetic modeling; Brain extracellular fluid; Cerebrospinal fluid; Microdialysis; Pharmacokinetics; Blood-brain barrier; Systems-based pharmacokinetic modeling; Brain extracellular fluid; Cerebrospinal fluid; Microdialysis

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APA (6th Edition):

Westerhout, J. (2014). Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution. (Doctoral Dissertation). Division of Pharmacology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/24379

Chicago Manual of Style (16th Edition):

Westerhout, Joost. “Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution.” 2014. Doctoral Dissertation, Division of Pharmacology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/24379.

MLA Handbook (7th Edition):

Westerhout, Joost. “Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution.” 2014. Web. 06 Aug 2020.

Vancouver:

Westerhout J. Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution. [Internet] [Doctoral dissertation]. Division of Pharmacology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/24379.

Council of Science Editors:

Westerhout J. Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution. [Doctoral Dissertation]. Division of Pharmacology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/24379

25. Maaden, Koen van der. Microneedle-mediated vaccine delivery.

Degree: 2014, division of Drug Delivery Technology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

 Conventional vaccines are administered intramuscularly or subcutaneously via hypodermic needles, causing pain and stress. Since the skin is a powerful immune organ, it is not… (more)

Subjects/Keywords: Microneedles; (Trans)dermal drug delivery; Derman vaccination; Surface modification; Functional coatings; Microneedles; (Trans)dermal drug delivery; Derman vaccination; Surface modification; Functional coatings

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APA (6th Edition):

Maaden, K. v. d. (2014). Microneedle-mediated vaccine delivery. (Doctoral Dissertation). division of Drug Delivery Technology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/29981

Chicago Manual of Style (16th Edition):

Maaden, Koen van der. “Microneedle-mediated vaccine delivery.” 2014. Doctoral Dissertation, division of Drug Delivery Technology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/29981.

MLA Handbook (7th Edition):

Maaden, Koen van der. “Microneedle-mediated vaccine delivery.” 2014. Web. 06 Aug 2020.

Vancouver:

Maaden Kvd. Microneedle-mediated vaccine delivery. [Internet] [Doctoral dissertation]. division of Drug Delivery Technology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/29981.

Council of Science Editors:

Maaden Kvd. Microneedle-mediated vaccine delivery. [Doctoral Dissertation]. division of Drug Delivery Technology of the Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/29981

26. Brill, Margreke Jantine Eltje. Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery.

Degree: 2015, Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

Drug concentrations and effects may be different in morbidly obese patients (body mass index > 40 kg/m2). In addition, also such changes may be expected… (more)

Subjects/Keywords: Morbid Obesity; Cefazolin; Midazolam; Bariatric surgery; Microdialysis; PK-PD modeling; Morbid Obesity; Cefazolin; Midazolam; Bariatric surgery; Microdialysis; PK-PD modeling

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APA (6th Edition):

Brill, M. J. E. (2015). Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery. (Doctoral Dissertation). Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/36511

Chicago Manual of Style (16th Edition):

Brill, Margreke Jantine Eltje. “Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery.” 2015. Doctoral Dissertation, Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/36511.

MLA Handbook (7th Edition):

Brill, Margreke Jantine Eltje. “Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery.” 2015. Web. 06 Aug 2020.

Vancouver:

Brill MJE. Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery. [Internet] [Doctoral dissertation]. Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2015. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/36511.

Council of Science Editors:

Brill MJE. Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery. [Doctoral Dissertation]. Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2015. Available from: http://hdl.handle.net/1887/36511

27. Monteiro Garrido Castro e Silva, Ana Luisa (Ana Luisa Silva). PLGA-based particulate vaccine delivery systems for immunotherapy of cancer.

Degree: 2015, Division of Drug Delivery Technology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University

 Synthetic long peptides (SLPs) derived from cancer antigens hold great promise as well-defined antigens for immunotherapy of cancer. However, the formulation of SLPs for in… (more)

Subjects/Keywords: Vaccine; Delivery systems; Antigen; Adjuvant; Dendritic cells; PLGA; Nanoparticles; Microparticles; Vaccine; Delivery systems; Antigen; Adjuvant; Dendritic cells; PLGA; Nanoparticles; Microparticles

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APA (6th Edition):

Monteiro Garrido Castro e Silva, A. L. (. L. S. (2015). PLGA-based particulate vaccine delivery systems for immunotherapy of cancer. (Doctoral Dissertation). Division of Drug Delivery Technology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/37169

Chicago Manual of Style (16th Edition):

Monteiro Garrido Castro e Silva, Ana Luisa (Ana Luisa Silva). “PLGA-based particulate vaccine delivery systems for immunotherapy of cancer.” 2015. Doctoral Dissertation, Division of Drug Delivery Technology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 06, 2020. http://hdl.handle.net/1887/37169.

MLA Handbook (7th Edition):

Monteiro Garrido Castro e Silva, Ana Luisa (Ana Luisa Silva). “PLGA-based particulate vaccine delivery systems for immunotherapy of cancer.” 2015. Web. 06 Aug 2020.

Vancouver:

Monteiro Garrido Castro e Silva AL(LS. PLGA-based particulate vaccine delivery systems for immunotherapy of cancer. [Internet] [Doctoral dissertation]. Division of Drug Delivery Technology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2015. [cited 2020 Aug 06]. Available from: http://hdl.handle.net/1887/37169.

Council of Science Editors:

Monteiro Garrido Castro e Silva AL(LS. PLGA-based particulate vaccine delivery systems for immunotherapy of cancer. [Doctoral Dissertation]. Division of Drug Delivery Technology, Leiden Academic Center for Drug Research (LACDR), Faculty of Science, Leiden University; 2015. Available from: http://hdl.handle.net/1887/37169

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