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1.
Olgiati, Simone.
Genetics of Movement Disorders in the Next-Generation Sequencing Era.
Degree: 2016, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/80040 
► markdownabstractMovement disorders are neurologic syndromes in which there is either an excess of movements or a paucity of voluntary and automatic movements, unrelated to weakness…
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▼ markdownabstractMovement disorders are neurologic syndromes in which there is either an excess of movements or a paucity of voluntary and automatic movements, unrelated to weakness or spasticity. These disorders are associated with dysfunctions of the basal ganglia and cerebellum, brain structures that together orchestrate the control of movements. During the last two decades, genetic studies of movement disorders identified many genetics factors associated with these diseases, including rare Mendelian factors, moderately-rare factors with moderate effect size, and common variants with low effect size. In the coming years, the application of novel DNA sequencing technologies to the study of movement disorders promises to unveil even more genetic factors, possibly leading to a full understanding of the genetic architecture of these disorders.
The introduction (Part I) of this thesis reviews the modern strategies for the identification of genetic factors associated with Mendelian forms of movement disorders. After a brief definition of these disorders, we focus on the use of the next-generation sequencing technologies to identify Mendelian mutations in movement disorders (chapter 1.1). Our experimental work is presented in the next three parts of this thesis. Part II is focused on the genetic studies of Parkinson’s disease (PD). In chapter 2.1, for the first time, we report the identification of DNAJC6 mutations in families with early-onset PD. Our work delineate a novel form of autosomal recessive early-onset PD, caused by mutations in the DNAJC6 gene, and has important implications for the diagnostic work-up and genetic counseling of early-onset PD patients. In chapter 2.2, we report genetic and clinical findings in a novel family with early-onset parkinsonism associated with triplication of the SNCA locus. This study contributes to the genetic and clinical characterization of this very rare form. In chapter 2.3, we perform a large exome sequencing project in the isolated population of Sardinia to identify novel risk factors for PD with intermediate or strong effect size. In this study we identify a list of candidate variants highly enriched or exclusively present in PD, a resource of candidates for future studies. Notably, this was the first study analyzing a large cohort of PD patients at exome-wide level.
Part III of this thesis focuses on the study of atypical forms of parkinsonisms. In chapter 3.1, we report the identification of a novel form of early-onset atypical parkinsonism caused by a homozygous mutation in SYNJ1. This study was the first to report the association between a SYNJ1 mutation and parkinsonism. In chapter 3.2, we identify a family with a milder phenotype caused by the same homozygous mutation in a different haplotype, suggesting that the two SYNJ1 mutations originated from different mutational events. Interestingly, the proteins encoded by SYNJ1 and DNAJC6 both act in the molecular pathway of the clathrin-mediated endocytosis, suggesting an involvement of this pathway in the pathogenesis…
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APA (6th Edition):
Olgiati, S. (2016). Genetics of Movement Disorders in the Next-Generation Sequencing Era. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/80040
Chicago Manual of Style (16th Edition):
Olgiati, Simone. “Genetics of Movement Disorders in the Next-Generation Sequencing Era.” 2016. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/80040.
MLA Handbook (7th Edition):
Olgiati, Simone. “Genetics of Movement Disorders in the Next-Generation Sequencing Era.” 2016. Web. 23 Apr 2018.
Vancouver:
Olgiati S. Genetics of Movement Disorders in the Next-Generation Sequencing Era. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2016. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/80040.
Council of Science Editors:
Olgiati S. Genetics of Movement Disorders in the Next-Generation Sequencing Era. [Doctoral Dissertation]. Erasmus University Medical Center; 2016. Available from: http://hdl.handle.net/1765/80040
2.
Nijman, Ruud.
Improving diagnostic strategies for predicting serious bacterial infections in children with fever.
Degree: 2014, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/77189
► textabstractThis thesis aimed to improve diagnostic strategies for predicting SBI in febrile children in emergency care settings. Generally, clinical signs and symptoms were of limited…
(more)
▼ textabstractThis thesis aimed to improve diagnostic strategies for predicting SBI in febrile children in emergency care settings. Generally, clinical signs and symptoms were of limited use in detecting SBI, even when using modelling techniques that best reflected their predictive ability. C-reactive protein (CRP) and procalcitonin (PCT) were useful diagnostic tools in the diagnostic management of febrile children, whereas neutrophil CD64 count was not. CRP and PCT had considerable incremental value to clinical signs and symptoms, and a prediction model consisting of clinical signs and symptoms and CRP performed well in derivation and validation studies.
Subjects/Keywords: fever; child; serious bacterial infection; prediction model; vital signs; respiratory rate; lower respiratory tract infections; biomarkers; C-reactive protein; procalcinonin; neutrophil CD64; fever phobia; Manchester Triage System; emergency department
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APA (6th Edition):
Nijman, R. (2014). Improving diagnostic strategies for predicting serious bacterial infections in children with fever. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/77189
Chicago Manual of Style (16th Edition):
Nijman, Ruud. “Improving diagnostic strategies for predicting serious bacterial infections in children with fever.” 2014. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/77189.
MLA Handbook (7th Edition):
Nijman, Ruud. “Improving diagnostic strategies for predicting serious bacterial infections in children with fever.” 2014. Web. 23 Apr 2018.
Vancouver:
Nijman R. Improving diagnostic strategies for predicting serious bacterial infections in children with fever. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2014. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/77189.
Council of Science Editors:
Nijman R. Improving diagnostic strategies for predicting serious bacterial infections in children with fever. [Doctoral Dissertation]. Erasmus University Medical Center; 2014. Available from: http://hdl.handle.net/1765/77189
3.
Voortman, Trudy.
Nutrition, body composition, and cardiometabolic health in children.
Degree: 2015, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/78796
► markdownabstractAbstract In the research described in this thesis we studied nutrition in early life, particularly in early childhood, and its association with body composition and…
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▼ markdownabstractAbstract
In the research described in this thesis we studied nutrition in early life, particularly in early childhood, and its association with body composition and cardiometabolic health. Nutritional factors of interest were protein intake, fatty acid intake and blood levels, vitamin D status, and dietary patterns. Studies include systematic reviews of the literature and analyses in the Generation R Study, a population-based prospective cohort from fetal life onward in Rotterdam, the Netherlands.
Overall, our results suggest that diet quality and vitamin D status in early childhood are suboptimal. Furthermore, our results show that a lower protein intake in early childhood, a fatty acid pattern characterized by high levels of n-3 fatty acids during fetal life, and an overall healthy dietary pattern in early childhood may be beneficial for later body composition and for certain cardiometabolic markers.
Although effect sizes were small, our findings may be important for early prevention of obesity and cardiometabolic diseases on a population level. Public health interventions and future scientific research should therefore put more focus on nutrition quality in early childhood.
Subjects/Keywords: Nutrition; epidemiology; early life; children; body composition; cardiometabolic health
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APA (6th Edition):
Voortman, T. (2015). Nutrition, body composition, and cardiometabolic health in children. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/78796
Chicago Manual of Style (16th Edition):
Voortman, Trudy. “Nutrition, body composition, and cardiometabolic health in children.” 2015. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/78796.
MLA Handbook (7th Edition):
Voortman, Trudy. “Nutrition, body composition, and cardiometabolic health in children.” 2015. Web. 23 Apr 2018.
Vancouver:
Voortman T. Nutrition, body composition, and cardiometabolic health in children. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2015. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/78796.
Council of Science Editors:
Voortman T. Nutrition, body composition, and cardiometabolic health in children. [Doctoral Dissertation]. Erasmus University Medical Center; 2015. Available from: http://hdl.handle.net/1765/78796
4.
Patandin, Svati.
Effects of environmental exposure to polychlorinated biphenyls and dioxins on growth and development in young children : a prospective follow-up study of breast-fed and formula-fed infants from birth until 42 months of age.
Degree: 1999, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19721
► textabstractPolychlorinated biphenyls (PCBs) as weli as dioxins, polychlorinated dibenzo-p-dioxins (PCDDs) and -dibenzo-furans (PCDFs) are potentially hazardous compounds in the environment. As in other industrialized countries,…
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▼ textabstractPolychlorinated biphenyls (PCBs) as weli as dioxins, polychlorinated
dibenzo-p-dioxins (PCDDs) and -dibenzo-furans (PCDFs) are potentially hazardous
compounds in the environment. As in other industrialized countries, contamination of
breast milk with PCBs and dioxins (PCDDslPCDFs) in the Netherlands has led to
considerable public concern. The Dutch government launched a prospective follow-up
study in 1989 to investigate the potential adverse effects of environmental exposure to
PCBs and dioxins on growth and development of the human foetus and newborn. The
observation period was expanded until 4 2 months of age in an EC-funded collaborative
project entitled: 'Neonatal PCB exposure and neurodevelopmental deficit', financed by
the ENVIRONMENTAL and CLIMATE research programme, DGXII of the European
Commission, Contract-No EVSV-CT92-0207. The study was designed to look into a
spectrum of PCB-related effects in order to decide if neurological and cognitive
development are affected by perinatal exposure to PCBs and related compounds, and if
European background concentrations represent levels of concern. In this multi center
cohort study, our Dutch cohort, a German and a Danish cohort are included. The work
in this thesis describes the results from the Dutch cohort. In this prospective
longitudinal study, breast-fed and formula-fed infants were studied from birth until 42
months of age. Results on growth, health and development until 42 months of age are
presented.
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APA (6th Edition):
Patandin, S. (1999). Effects of environmental exposure to polychlorinated biphenyls and dioxins on growth and development in young children : a prospective follow-up study of breast-fed and formula-fed infants from birth until 42 months of age. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19721
Chicago Manual of Style (16th Edition):
Patandin, Svati. “Effects of environmental exposure to polychlorinated biphenyls and dioxins on growth and development in young children : a prospective follow-up study of breast-fed and formula-fed infants from birth until 42 months of age.” 1999. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19721.
MLA Handbook (7th Edition):
Patandin, Svati. “Effects of environmental exposure to polychlorinated biphenyls and dioxins on growth and development in young children : a prospective follow-up study of breast-fed and formula-fed infants from birth until 42 months of age.” 1999. Web. 23 Apr 2018.
Vancouver:
Patandin S. Effects of environmental exposure to polychlorinated biphenyls and dioxins on growth and development in young children : a prospective follow-up study of breast-fed and formula-fed infants from birth until 42 months of age. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1999. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19721.
Council of Science Editors:
Patandin S. Effects of environmental exposure to polychlorinated biphenyls and dioxins on growth and development in young children : a prospective follow-up study of breast-fed and formula-fed infants from birth until 42 months of age. [Doctoral Dissertation]. Erasmus University Medical Center; 1999. Available from: http://hdl.handle.net/1765/19721
5.
Visser, Anna.
Simultaneous Recording of Mechanical and Intracellular Electrical Activity in Urinary Bladder Smooth Muscle.
Degree: 2000, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19713
► textabstractIn the 1940's, an elegant and exciting new teclmique was introduced: the penetration of a delicate cell membrane, enabling the monitoring of the electrical activity…
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▼ textabstractIn the 1940's, an elegant and exciting new teclmique was introduced: the
penetration of a delicate cell membrane, enabling the monitoring of the electrical
activity of living cells. A very flne tip of a thin glass tube fllled with a conducting
solution, called a microeiectrodc, was inserted into a cell, connecting the interior of the
cell to the outside world. TIle idea itself originated around 1902, but the technique was
not applied successfully until halfway through the 20~ century. Following the
pioneering work, refmcmcllts were made and the method was used in an increasing
number of laboratories.
In the begullling, attention was mainly concentrated on larger cells without
abundant cOIDlcctive tissue: striated muscle and neUfOlles, hut gradually, the technique
was also applied to smooth muscle. With every action potential recorded, knowledge
about the underlying electrophysiological processes increased, although the progress
was slow. Even in 1968, the ionic basis of smooth muscle action potentials was not
known, although by then it was suspected to be calcium instead of sodium, as in
neurones [46].
The urinary bladder consists of a mucosal layer on the lumen side, a
connective tissue layer on the outside and the detmsor, a smooth muscle layer, inM
between. It is clinically relevant to unravel the mechanism behind detrusor
contraction. Nonnally, urine produced in the kidneys is stored in the urinary bladder
under low pressure conditions. At a convenient moment, the urine is then expelled
rapidly at a high pressure, under cholinergic control. In some patients however, the
detmsor spontaneously and involuntarily contracts during the storage phase. TIlis may
lead to urine loss, and additionally, the rise in pressure may lead to reflux of urine to
the kidneys with a possibility of kidney damage. Electrophysiology is an essential tool
to uncover the physiological basis of this disorder.
The detnlsor muscle has all characteristics of jeopardising successful
intracellular recordings: it consists of an integrated network of muscle bundles,
orientated randomly. The muscle bundles, UI tum, are formed by long, thin cells,
varying from 150 to 300 ~m length, and 6 to 8 ~m in diameter. In addition, the cells
are amply embedded in connective tissue. Apart from these features, which are a
hindrance for impalement, the cells display constant mechanical activity, increasing
the chance of dislodging the electrode from the cell, once it is impaled.
Still, attempts were made and the flrst, and for a long time also the only
article to be published on combined intracellular electrical and mechanical activity of
urulary bladder smooth muscle origulates from 1961, describing experiments made in
rabbit detrusor.
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APA (6th Edition):
Visser, A. (2000). Simultaneous Recording of Mechanical and Intracellular Electrical Activity in Urinary Bladder Smooth Muscle. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19713
Chicago Manual of Style (16th Edition):
Visser, Anna. “Simultaneous Recording of Mechanical and Intracellular Electrical Activity in Urinary Bladder Smooth Muscle.” 2000. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19713.
MLA Handbook (7th Edition):
Visser, Anna. “Simultaneous Recording of Mechanical and Intracellular Electrical Activity in Urinary Bladder Smooth Muscle.” 2000. Web. 23 Apr 2018.
Vancouver:
Visser A. Simultaneous Recording of Mechanical and Intracellular Electrical Activity in Urinary Bladder Smooth Muscle. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2000. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19713.
Council of Science Editors:
Visser A. Simultaneous Recording of Mechanical and Intracellular Electrical Activity in Urinary Bladder Smooth Muscle. [Doctoral Dissertation]. Erasmus University Medical Center; 2000. Available from: http://hdl.handle.net/1765/19713
6.
Feber, Joost.
Neurophysiological modeling of Voiding in Rats.
Degree: 2000, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19712
► textabstractLike man, most animals need a regular supply of nutriments. Eating and drinking cater for this need, but not with 100% efficiency. A considerable part…
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▼ textabstractLike man, most animals need a regular supply of nutriments. Eating and drinking cater for this
need, but not with 100% efficiency. A considerable part of the conswned goods are expelled
from the body as defecation. Waste products from the blood are filtered by the kidneys and
excreted as urine. 1ms process continues throughout the day. In many situations, however, it
would be very inconvenient to be expelling urine. Animals that leak urine continuously are
more easily traced by preditors than the ones that don't. Besides this, for mankind it is socially
intolerable at certain moments. Nature supplied q solution that enables storage of urine until a
convenient moment for voiding: the bladder. Upon desire the bladder contracts and urine is
expelled through the urethra, which, with the bladder, constitutes ti,e lower urinary tract. Thus
the bladder owner controls when and where to expel urine.
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APA (6th Edition):
Feber, J. (2000). Neurophysiological modeling of Voiding in Rats. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19712
Chicago Manual of Style (16th Edition):
Feber, Joost. “Neurophysiological modeling of Voiding in Rats.” 2000. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19712.
MLA Handbook (7th Edition):
Feber, Joost. “Neurophysiological modeling of Voiding in Rats.” 2000. Web. 23 Apr 2018.
Vancouver:
Feber J. Neurophysiological modeling of Voiding in Rats. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2000. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19712.
Council of Science Editors:
Feber J. Neurophysiological modeling of Voiding in Rats. [Doctoral Dissertation]. Erasmus University Medical Center; 2000. Available from: http://hdl.handle.net/1765/19712
7.
Lionarons, Wendell.
Dwangopneming bij personlijkheidsstoornissen: ethische en psychopathologische aspecten.
Degree: 2000, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19711
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APA (6th Edition):
Lionarons, W. (2000). Dwangopneming bij personlijkheidsstoornissen: ethische en psychopathologische aspecten. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19711
Chicago Manual of Style (16th Edition):
Lionarons, Wendell. “Dwangopneming bij personlijkheidsstoornissen: ethische en psychopathologische aspecten.” 2000. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19711.
MLA Handbook (7th Edition):
Lionarons, Wendell. “Dwangopneming bij personlijkheidsstoornissen: ethische en psychopathologische aspecten.” 2000. Web. 23 Apr 2018.
Vancouver:
Lionarons W. Dwangopneming bij personlijkheidsstoornissen: ethische en psychopathologische aspecten. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2000. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19711.
Council of Science Editors:
Lionarons W. Dwangopneming bij personlijkheidsstoornissen: ethische en psychopathologische aspecten. [Doctoral Dissertation]. Erasmus University Medical Center; 2000. Available from: http://hdl.handle.net/1765/19711
8.
Berg, Cardi.
Quality and ReHability of Prenatal Cytogenetics.
Degree: 2002, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19706
► textabstractIn the early fifties, prenatal investigation of amniotic fluid started with the evaluation of Rhesus sensitization (Bevis, 1950, 1952). It was followed by the discovery…
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▼ textabstractIn the early fifties, prenatal investigation of amniotic fluid started with the evaluation
of Rhesus sensitization (Bevis, 1950, 1952). It was followed by the discovery that fetal
gender could be determined by the presence or absence of a sex chromatin body in
the nuclei of cells in the amniotic fluid (Fuchs and Riis, 1956).
In 1966, Steele and Breg demonstrated the possibility of culturing and karyotyping
viabie amniotic fluid ceUs, rnainly of epithelial origin. Further progress was made
with the refinernent of the technique and timing of arnniocentesis (Thiede et al., 1966;
Jacobson and Barter, 1967), and the first prenatal diagnosis of Down syndrome
(Valenti et al., 1968).
Other important developments, in the same period, were the use of amniocentesis for
the prenatal detection of biochemical abnormalities (Nadier and Gerbie, 1968), the
development of ultramicrochemical techniques for rapid prenatal biochemical
diagnosis (Galjaard et al., 1972, 1977, 1980; Niermeijer et al., 1975), and the finding of
an association between a raised concentration of alpha-fetoprotein in arnniotic fluid
and an open neural tube defect of the fetus (Brock and Sutcliffe, 1972). Cytogenetic
investigations were improved by the discovery of the G-banding technique
(Seabright, 1971).
For almost fifteen years alnniocentesis was the only procedure for prenatal
investigations. At the end of the eighties, more than a quarter of a million
amniocenteses had been performed and the nurnber to date is probably in the
rniilions. Nowadays, the safety of second trimester arnniocentesis together with the
reliability, accuracy and efficiency is weil recognized; it is generally considered as the
" gold standard".
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APA (6th Edition):
Berg, C. (2002). Quality and ReHability of Prenatal Cytogenetics. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19706
Chicago Manual of Style (16th Edition):
Berg, Cardi. “Quality and ReHability of Prenatal Cytogenetics.” 2002. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19706.
MLA Handbook (7th Edition):
Berg, Cardi. “Quality and ReHability of Prenatal Cytogenetics.” 2002. Web. 23 Apr 2018.
Vancouver:
Berg C. Quality and ReHability of Prenatal Cytogenetics. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2002. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19706.
Council of Science Editors:
Berg C. Quality and ReHability of Prenatal Cytogenetics. [Doctoral Dissertation]. Erasmus University Medical Center; 2002. Available from: http://hdl.handle.net/1765/19706
9.
Ibrahim, Shehu.
Quantitative Fluorescence Microscopy of Protein Dynamics in Living Cells.
Degree: Department of Genetics, 2006, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/8211
► textabstractThe advent of confocal microscopy, fast microcomputers with high storage capacity and, moreover, the availability of fluorescent proteins of various excitation and emission properties have…
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▼ textabstractThe advent of confocal microscopy, fast microcomputers with high storage capacity
and, moreover, the availability of fluorescent proteins of various excitation and
emission properties have made fluorescence microscopy the method of choice in the
study of protein behaviour in living cells. In this thesis we investigated in detail two
important quantitative methods, fluorescence correlation spectroscopy (FCS) and
fluorescence recovery after photobleaching (FRAP). Model systems used in
demonstrating the complementarity of the techniques and their merits included the
nuclear excision repair (NER) system, transcription regulation by the androgen receptor
(AR), and signal transduction by two membrane receptors, the EGF receptor and the
IL2-receptor.
In Chapter 1 an introduction to microscopy is given. A brief history traces the
development of microscopy from the modest lens arrangement of Zacharias Janssen to
modern fluorescence microscopes allowing quantitative investigation of protein
dynamics in living cells. A discussion of fluorescence properties of the GFP is
presented and several quantitative fluorescence microscopy techniques used are
discussed. Also the model systems studied are described.
In Chapter 2 the long-lived dark state of EGFP, the fluorescent tag used in most live
cell studies, is investigated as observed in a set-up similar to a typical fluorescence
recovery after photobleaching (FRAP) experiment. A method is presented to measure
light induced fluorescence fluctuations due to transitions between the dark and
excitable state of EGFP in bulk samples. We have found that the average lifetime of the
long-lived dark state of the chromophore is about 2.3 s irrespective of the excitation
intensity whereas the average on-time is dependent on the intensity used.
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APA (6th Edition):
Ibrahim, S. (2006). Quantitative Fluorescence Microscopy of Protein Dynamics in Living Cells. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/8211
Chicago Manual of Style (16th Edition):
Ibrahim, Shehu. “Quantitative Fluorescence Microscopy of Protein Dynamics in Living Cells.” 2006. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/8211.
MLA Handbook (7th Edition):
Ibrahim, Shehu. “Quantitative Fluorescence Microscopy of Protein Dynamics in Living Cells.” 2006. Web. 23 Apr 2018.
Vancouver:
Ibrahim S. Quantitative Fluorescence Microscopy of Protein Dynamics in Living Cells. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2006. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/8211.
Council of Science Editors:
Ibrahim S. Quantitative Fluorescence Microscopy of Protein Dynamics in Living Cells. [Doctoral Dissertation]. Erasmus University Medical Center; 2006. Available from: http://hdl.handle.net/1765/8211
10.
Legerstee, Jeroen.
Toward an Optimal Treatment for Childhood Anxiety Disorders: The Influence of Parental Psychopathology, Selective Attention, and Cognitive Coping.
Degree: 2009, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19703
► textabstractThe aim of the present thesis was to explore wether parental psychopathology and threat-related selective attention were related to outcome of cognitive-behavioral therapy in anxiety-disordered…
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▼ textabstractThe aim of the present thesis was to explore wether parental psychopathology and threat-related selective attention were related to outcome of cognitive-behavioral therapy in anxiety-disordered children and adolescents. Pre- to post-treatment changes of selective attention were also examined in relation to treatment success. The second aim was to examine whether cognitive coping after the experience of negative life events is related to anxiety disorders in children and adolescents.
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APA (6th Edition):
Legerstee, J. (2009). Toward an Optimal Treatment for Childhood Anxiety Disorders: The Influence of Parental Psychopathology, Selective Attention, and Cognitive Coping. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19703
Chicago Manual of Style (16th Edition):
Legerstee, Jeroen. “Toward an Optimal Treatment for Childhood Anxiety Disorders: The Influence of Parental Psychopathology, Selective Attention, and Cognitive Coping.” 2009. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19703.
MLA Handbook (7th Edition):
Legerstee, Jeroen. “Toward an Optimal Treatment for Childhood Anxiety Disorders: The Influence of Parental Psychopathology, Selective Attention, and Cognitive Coping.” 2009. Web. 23 Apr 2018.
Vancouver:
Legerstee J. Toward an Optimal Treatment for Childhood Anxiety Disorders: The Influence of Parental Psychopathology, Selective Attention, and Cognitive Coping. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2009. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19703.
Council of Science Editors:
Legerstee J. Toward an Optimal Treatment for Childhood Anxiety Disorders: The Influence of Parental Psychopathology, Selective Attention, and Cognitive Coping. [Doctoral Dissertation]. Erasmus University Medical Center; 2009. Available from: http://hdl.handle.net/1765/19703
11.
Raaij, Tom.
Treatment of Symptomatic Varus Osteoarthritis of the Knee.
Degree: 2009, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19700
► textabstractOsteoarthritis (OA) is the 6th leading cause of Years Lost to Disability (YLD) at global level, accounting for 3% of total global YLDs. Knee OA…
(more)
▼ textabstractOsteoarthritis (OA) is the 6th leading cause of Years Lost to Disability (YLD) at global level, accounting for 3% of total global YLDs. Knee OA is the most common joint disorder, and in the Netherlands approximately 17% of the population aged 45 years and over suffer from knee OA. It causes considerable pain and immobility, affects independence and psychosocial functioning, and in addition leads to financial losses. Many patients present with unicompartmental disease, and the medial compartment is almost 10 times more frequently involved than the lateral compartment. This thesis investigates both the non-operative and surgical treatment outcomes in active patients with symptomatic medial OA of the knee. The aim is to clarify indications for identified treatment modalities as controversy exists on how patient and/or intervention related factors affect the outcome of this disease. Furthermore, clearer indications will lead to better care, which may not only benefit the individual patient but also society as a whole because of expected savings in health care expenses and reduction of productivity losses.
Patients with OA of the medial compartment often have varus malalignment; the mechanical axis and load bearing passes through the medial compartment. Some report that malalignment may even have an impact on the development and progression of knee OA. Although many consider whole leg radiographs in standing position (mechanical axis measurement) as the gold standard to determine knee alignment, in clinical practice, knee alignment is often assessed on shorter anterior-posterior knee radiographs (anatomic axis measurement) to cut expenses and cumbersome procedures. Significant correlation between mechanical and anatomic axis angles has been reported. Some suggest using anatomic axis measurement in research and clinical settings. In Chapter 2 we compare two different methods of anatomic axis assessment in a group of patients with known mechanical varus alignment, and determine whether or not anatomic axis measurement on standard short knee views can be used in clinical settings.
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APA (6th Edition):
Raaij, T. (2009). Treatment of Symptomatic Varus Osteoarthritis of the Knee. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19700
Chicago Manual of Style (16th Edition):
Raaij, Tom. “Treatment of Symptomatic Varus Osteoarthritis of the Knee.” 2009. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19700.
MLA Handbook (7th Edition):
Raaij, Tom. “Treatment of Symptomatic Varus Osteoarthritis of the Knee.” 2009. Web. 23 Apr 2018.
Vancouver:
Raaij T. Treatment of Symptomatic Varus Osteoarthritis of the Knee. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2009. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19700.
Council of Science Editors:
Raaij T. Treatment of Symptomatic Varus Osteoarthritis of the Knee. [Doctoral Dissertation]. Erasmus University Medical Center; 2009. Available from: http://hdl.handle.net/1765/19700
12.
Hoeks, Sanne.
Perioperative Cardiac Care: From Guidelines to Clinical Practice.
Degree: 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19699
► textabstractCardiovascular disease is the major cause of death and disability in the Western world. The main disease underlying cardiovascular disorders is atherosclerosis. Atherosclerosis is a…
(more)
▼ textabstractCardiovascular disease is the major cause of death and disability in the Western world. The main
disease underlying cardiovascular disorders is atherosclerosis. Atherosclerosis is a systemic
disease affecting numerous vascular beds, including the coronary and peripheral circulation
i.e. cerebrovascular, aortic and lower limb arterial circulation. The global ageing phenomenon
will further increase the burden of cardiovascular disease and also enforce a change in health
care towards the elderly population. Peripheral arterial disease (PAD) is a common condition.
Importantly, only 1 out of 9 patients with PAD are symptomatic while vascular morbidity and
mortality is estimated to be similar in patients with symptomatic or asymptomatic PAD. This
poses PAD to be a major health burden. Risk factors for atherosclerotic disease are common and
polyvascular disease is highly prevalent in the PAD population. The prognosis of patients with PAD
is predominantly determined by the presence and extent of the underlying ischemic heart disease
(IHD). The estimated cardiovascular risk in PAD is, moreover, as high as in IHD.3,4 Mc Dermott
and colleagues reported already in 1997 that PAD patients received less intensive drug treatment
compared to IHD patients, irrespective of comparable risk. Additionally, in a large risk factor
matched population, patients with IHD received more cardiac medications, compared with PAD
patients (beta-blockers 74% vs. 34%, aspirin 88% vs. 40%, nitrates 37% vs. 19%, statins 67% vs. 29% and
ACE-inhibitors 57% vs. 31%, respectively). The observed poor medical control of PAD patients may
be an explanation for the worse outcome of PAD patients compared with IHD patients as observed
by the study of Welten et al. The REACH registry showed that cardiovascular events increased in
a stepwise fashion with the number of symptomatic vascular beds.4 The combined 1-year outcome
of atherothrombotic events ranged from 17% in patients with PAD as a single affected vascular bed
to 26% in patients with 3 diseased vascular beds. Patients with PAD undergoing vascular surgery
are known to be at higher risk for both early and late cardiovascular events compared to patients
with IHD.3,7 Hertzer’s landmark study in 1000 consecutive patients undergoing surgery for PAD
who underwent preoperative cardiac catheterizations reported that only 8% had normal coronary
arteries, and approximately one third had severe-correctable or severe-inoperable IHD.
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APA (6th Edition):
Hoeks, S. (2010). Perioperative Cardiac Care: From Guidelines to Clinical Practice. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19699
Chicago Manual of Style (16th Edition):
Hoeks, Sanne. “Perioperative Cardiac Care: From Guidelines to Clinical Practice.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19699.
MLA Handbook (7th Edition):
Hoeks, Sanne. “Perioperative Cardiac Care: From Guidelines to Clinical Practice.” 2010. Web. 23 Apr 2018.
Vancouver:
Hoeks S. Perioperative Cardiac Care: From Guidelines to Clinical Practice. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19699.
Council of Science Editors:
Hoeks S. Perioperative Cardiac Care: From Guidelines to Clinical Practice. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19699
13.
Sewgobind, Varsha.
Immunosuppressive Drugs and Immune Regulation in Organ Transplantation.
Degree: 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19694
► textabstractSolid organ transplantation is during the past two decades the fi nest and most suitable treatment with the best quality of life for patients with…
(more)
▼ textabstractSolid organ transplantation is during the past two decades the fi nest and most suitable treatment
with the best quality of life for patients with end stage organ failure. The fi rst documented
‘unrelated’ kidney transplantation was performed on June 17, 1950 in Chicago, United States
on a 44-year-old woman with polycystic kidney disease2. Unfortunately, the donated kidney
was rejected because no adequate immunosuppressive therapy was available at the time and
the development of eff ective anti-rejection drugs was years away. The fi rst successful kidney
transplantation was performed on December 23rd in 1954 from one healthy identical twin to
his twin brother who was almost dying of renal disease3. The operation succeeded and renal
function was restored in the recipient and resulted in enormous excitement in the media and
among medical professionals. One decade further, the fi rst human liver transplantation was
performed in 1963 by a surgical team led by dr. Thomas Starzl4.
The discovery and availability of potent immunosuppressive drugs that were able to prevent
rejection of the transplanted donor graft, was followed by an era of many successful solid organ
transplantations. The use of these immunosuppressive drugs resulted in acceptable graftsurvival
rates in the Netherlands. The graft survival rate over 2007 was 94% after clinical kidney
transplantation with living donors, 85% after clinical kidney transplantation with deceased
donors and 76% after clinical liver transplantation (Nederlandse Transplantatie Stichting).
Nevertheless, acute rejection may occur in the fi rst 3 to 6 months after transplantation, but this
can be well treated with (steroid) anti-rejection therapy.
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APA (6th Edition):
Sewgobind, V. (2010). Immunosuppressive Drugs and Immune Regulation in Organ Transplantation. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19694
Chicago Manual of Style (16th Edition):
Sewgobind, Varsha. “Immunosuppressive Drugs and Immune Regulation in Organ Transplantation.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19694.
MLA Handbook (7th Edition):
Sewgobind, Varsha. “Immunosuppressive Drugs and Immune Regulation in Organ Transplantation.” 2010. Web. 23 Apr 2018.
Vancouver:
Sewgobind V. Immunosuppressive Drugs and Immune Regulation in Organ Transplantation. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19694.
Council of Science Editors:
Sewgobind V. Immunosuppressive Drugs and Immune Regulation in Organ Transplantation. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19694
14.
Schouw, Renata.
Early Pain, Beware the Brain! Long-term effects of neonatal pain experiences.
Degree: Department of Pediatric Surgery, 2006, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/8210
► textabstractThe past twenty years have seen great progress in our knowledge of paediatric pain. Especially our understanding of neonatal pain processing and neurobehavioral development has…
(more)
▼ textabstractThe past twenty years have seen great progress in our knowledge of paediatric
pain. Especially our understanding of neonatal pain processing and neurobehavioral development
has much deepened. Today, the human central nervous system (CNS) is generally
acknowledged to be very immature at birth and to show great plasticity during the
first year of life. Andrews and Fitzgerald most clearly demonstrated the immaturity of the
CNS in humans, in that pain on the short-term decreased the pain threshold. However,
until now only few studies have evaluated the prolonged effects of neonatal pain exposure
in humans, and results are conflicting. .
In order to evaluate whether pain or tissue damage in early life will lead to hypersensitivity
persisting into childhood, we performed a cross-sectional study (Chapter
2). A total of 164 infants were included to determine if major surgery within the first 3
months of life increases pain sensitivity during subsequent surgery. Moreover, we wanted
to evaluate whether apart from subsequent surgery in the same dermatome, also
subsequent surgery in a different dermatome would alter pain sensitivity. All children received
standard intraoperative and postoperative pain management. Rescue analgesic
administration was guided by a treatment algorithm. Outcome measures to determine
differences in pain sensitivity were assessed by the intraoperative fentanyl intake and by
(nor)epinephrine plasma concentrations. Observational pain ratings from the COMFORT
behaviour scale and Visual Analogue Scale (VAS), morphine intake and (nor)epinephrine
plasma concentrations, served to assess differences in postoperative pain sensitivity.
We found that only the infants previously operated upon in the same dermatome
needed more intraoperative fentanyl, had higher COMFORT and VAS scores, had greater
(nor)epinephrine plasma concentrations, and also needed more morphine than did infants
with no prior surgery. The children previous operated upon in another dermatome
only demonstrated higher postoperative analgesic requirements and norepinephrine
plasma concentrations in comparison with infants with no prior surgery. These preliminary
findings could indicate that neuroanatomical changes in the spinal and possibly
also supraspinal nervous system have developed as a result of neonatal surgery. We conclude
that the long-term consequences of surgery in early infancy are greatest in areas of
prior tissue damage, which may portend limited clinical but important neurobiological
differences.
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APA (6th Edition):
Schouw, R. (2006). Early Pain, Beware the Brain! Long-term effects of neonatal pain experiences. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/8210
Chicago Manual of Style (16th Edition):
Schouw, Renata. “Early Pain, Beware the Brain! Long-term effects of neonatal pain experiences.” 2006. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/8210.
MLA Handbook (7th Edition):
Schouw, Renata. “Early Pain, Beware the Brain! Long-term effects of neonatal pain experiences.” 2006. Web. 23 Apr 2018.
Vancouver:
Schouw R. Early Pain, Beware the Brain! Long-term effects of neonatal pain experiences. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2006. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/8210.
Council of Science Editors:
Schouw R. Early Pain, Beware the Brain! Long-term effects of neonatal pain experiences. [Doctoral Dissertation]. Erasmus University Medical Center; 2006. Available from: http://hdl.handle.net/1765/8210
15.
Khan, Nisar Ahmed.
Immunoregulatory Properties of Break Down Products of Human Choriogonadotropin.
Degree: 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19612
► textabstractReproductive function in the female is cyclic. A series of functional interrelationships between the hypothalamus, the anterior pituitary, and the ovaries leads to the monthly…
(more)
▼ textabstractReproductive function in the female is cyclic. A series of functional interrelationships between the hypothalamus, the anterior pituitary, and the ovaries leads to the monthly rupture of an ovarian follicle and extrusion of an egg (“ovulation”), which is then transported to the fallopian tubes to be fertilized. Should fertilization fail to occur, menstruation ensues within 14 days and the hormonal and morphological events that led to ovulation are repeated.
Ovulation occurs around day 14 of the menstrual cycle, followed by fertilization as egg and sperm unite within 24 hours. The first three days of development occur within the fallopian tube. Upon arrival within the uterus the conceptus develops into a blastocyst (Figure 1) and begins to make mRNA for human chorionic gonadotropin (hCG), the first hormone signal from the early embryo. By day 6 after fertilization the blastocyst initiates implantation into the maternal endometrium or uterine lining.
Within a few days of fertilization the blastocyst becomes a spherical structure composed of two layers. The outside layer of cells become trophoblasts and the inside of a group of cells called the inner cell mass (Figure 2A) will develop into the fetus and ultimately the baby. In addition to making hCG, the trophoblasts mediate the implantation process by attaching to, and eventually invading into the endometrium (Figure 2B). Once firmly attached to the endometrium the developing conceptus grows and continues to expand into the endometrium. One of the basic paradigms which is established even within the first week of gestation is that the embryonic/fetal cells are always separated from maternal tissues and blood by a layer of cytotrophoblasts (mononuclear trophoblasts) and syncytiotrophoblasts (multinucleated trophoblasts) (Figure 2C-F). This is critical not only for nutrient exchange, but also to protect the developing fetus from maternal immunologic attack (1).
Implantation is regulated by a complex interplay between trophoblasts and endometrium. On the one hand trophoblasts have a potent invasive capacity and if allowed to invade unchecked, spread throughout the uterus. The endometrium, on the other hand, controls trophoblast invasion by secreting locally acting factors (i.e. cytokines and protease inhibitors), which modulate trophoblast invasion. Within the placenta the syncytiotrophoblasts generate high levels of hCG which modulates cytotrophoblast differentiation towards a non-invasive hormone secreting villous-type trophoblast.
The closer the trophoblasts are to the endometrium the less hCG is made, allowing the trophoblasts to differentiate into anchoring type cells (2). Trophoblasts that leave the placenta and migrate within the endo and myometrium are induced to make
proteases and protease inhibitors, to further facilitate trophoblast invasion into the maternal tissues (2). Ultimately, normal implantation and placentation is a balance between regulatory gradients created by both the trophoblasts and the endometrium.
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APA (6th Edition):
Khan, N. A. (2010). Immunoregulatory Properties of Break Down Products of Human Choriogonadotropin. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19612
Chicago Manual of Style (16th Edition):
Khan, Nisar Ahmed. “Immunoregulatory Properties of Break Down Products of Human Choriogonadotropin.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19612.
MLA Handbook (7th Edition):
Khan, Nisar Ahmed. “Immunoregulatory Properties of Break Down Products of Human Choriogonadotropin.” 2010. Web. 23 Apr 2018.
Vancouver:
Khan NA. Immunoregulatory Properties of Break Down Products of Human Choriogonadotropin. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19612.
Council of Science Editors:
Khan NA. Immunoregulatory Properties of Break Down Products of Human Choriogonadotropin. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19612
16.
Leest, Cor.
Optical and Functional Imaging in Lung Cancer.
Degree: Department of Pulmonology, 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19596
► textabstractLung cancer is the second most common cancer in men and women, and is the leading cause of cancer related death. In industrialized countries the…
(more)
▼ textabstractLung cancer is the second most common cancer in men and women, and is the
leading cause of cancer related death. In industrialized countries the mortality rate
of lung cancer is higher than the mortality rate of breast, colorectal and prostate
cancer combined 1. When lung cancer is diagnosed at an early stage patients are
considered to have the best overall survival rate 2. Unfortunately, only a minority of
patients is currently diagnosed at a curable stage of disease. The lack of specific
symptoms at an early stage of the disease, the rapid growth of tumor cells and the
metastatic behavior of lung tumors are the main reasons for a diagnosis at an
advanced stage.
Non-small-cell lung cancer (NSCLC) can be divided into three major histological
subtypes: squamouscell carcinoma, adenocarcinoma, and large-cell carcinoma 3.
Eighty-five percent of the lung cancer patients are diagnosed with NSCLC, and
75% of the patients are diagnosed with an incurable stage IIIB or IV disease 4, 5.
Fifteen percent of the lung cancer patients have small-cell-lung cancer (SCLC)
and the 5-year survival for them is even lower than for NSCLC 6.
Whereas originally smoking is at the root of all types of lung cancer, the incidence
of lung cancer in never smokers increases 7. Smoking is most strongly linked with
SCLC and squamous-cell carcinoma 8, 9, although after the introduction of filter
cigarets an increased incidence of adenocarcinomas was observed 10. This
resulted in a change in ratio of adenocarcinomas-squamous cell carcinomas
towards adenocarcinomas 8, 11. In some countries squamous cell carcinoma is still
the most common histological type of lung cancer in male patients, e.g. France
(41%) and United Kingdom (40%). In other countries adenocarcinoma is the most
common type e.g. USA and Canada 12. In patients without a smoking history
adenocarcinoma is most common 13-16.
Despite new insights and improved medical treatments, lung cancer remains the
type of cancer with the highest mortality. Additional studies are needed to improve
detection of lung cancer in an early (pre)malignant stage to improve survival.
Improved pretreatment staging of lung cancer is necessary to prevent under- or
over treatment. Furthermore a better understanding of tumor behavior improves
treatment modalities.
In this introduction the histological subtypes of lung cancer, the microenvironment
of lung cancer and systemic treatment modalities are described. Furthermore
several imaging techniques to analyze the microenvironment of lung cancer tissue
are discussed.
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APA (6th Edition):
Leest, C. (2010). Optical and Functional Imaging in Lung Cancer. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19596
Chicago Manual of Style (16th Edition):
Leest, Cor. “Optical and Functional Imaging in Lung Cancer.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19596.
MLA Handbook (7th Edition):
Leest, Cor. “Optical and Functional Imaging in Lung Cancer.” 2010. Web. 23 Apr 2018.
Vancouver:
Leest C. Optical and Functional Imaging in Lung Cancer. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19596.
Council of Science Editors:
Leest C. Optical and Functional Imaging in Lung Cancer. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19596
17.
Veenstra, Marja.
Alcohol and Cardiovascular Disease: Impact of Life Events and Social Support (A Primary Care-based Longitudinal Study).
Degree: 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19595
► textabstractThe relationship between alcohol use and cardiovascular disease is repeatedly investigated in epidemiological studies, and mostly described as J-shaped or U-shaped with a higher risk…
(more)
▼ textabstractThe relationship between alcohol use and cardiovascular disease is repeatedly investigated in epidemiological
studies, and mostly described as J-shaped or U-shaped with a higher risk for non-drinkers and
heavy drinkers, and a lower risk for moderate drinkers (1). However, there is still a scientific debate on
the apparent protective effects of alcohol use on coronary heart disease, which is not ready to be closed
down (2, 3). Several possible biological mechanisms have been brought forward to explain the apparent
beneficial effects of moderate alcohol use (4, 5). Alcohol use has been found to increase high-density
lipoprotein cholesterol, to reduce blood clotting and platelet aggregation, to decrease insulin resistance
and increase insulin sensitivity, to reduce plasma homocysteine levels, to increase paraoxonase activity,
and to raise oestrogen levels. Negative effects of increased alcohol use are an increase in blood pressure
and damage to myocardial tissue. The question remains whether alcohol use is really beneficial, there
might be other explanations, such as psychological mechanisms or methodological pitfalls, relevant in
explaining the J-shaped curve in addition to these potential biological explanations.
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APA (6th Edition):
Veenstra, M. (2010). Alcohol and Cardiovascular Disease: Impact of Life Events and Social Support (A Primary Care-based Longitudinal Study). (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19595
Chicago Manual of Style (16th Edition):
Veenstra, Marja. “Alcohol and Cardiovascular Disease: Impact of Life Events and Social Support (A Primary Care-based Longitudinal Study).” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19595.
MLA Handbook (7th Edition):
Veenstra, Marja. “Alcohol and Cardiovascular Disease: Impact of Life Events and Social Support (A Primary Care-based Longitudinal Study).” 2010. Web. 23 Apr 2018.
Vancouver:
Veenstra M. Alcohol and Cardiovascular Disease: Impact of Life Events and Social Support (A Primary Care-based Longitudinal Study). [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19595.
Council of Science Editors:
Veenstra M. Alcohol and Cardiovascular Disease: Impact of Life Events and Social Support (A Primary Care-based Longitudinal Study). [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19595
18.
Steenbergen, Liza.
Variation in Occurrence, Management, and Outcome of Colorectal Cancer in the Netherlands, on the Eve of Mass Screening.
Degree: 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19573
► textabstractThe large bowel can be divided into the colon, the rectosigmoid, and the rectum. The colon starts where the small bowel ends and it is…
(more)
▼ textabstractThe large bowel can be divided into the colon, the rectosigmoid, and the rectum. The colon starts where the small bowel ends and it is 1.5-1.8 metres long when stretched. The rectum forms the final 10-15 cm of the large bowel, opening to the outside at the anus. The rectosigmoid is the transitional zone between the colon and the rectum.
Colorectal cancer (CRC) is the third most frequent cancer (14%) among males, after prostate (22%) and lung cancer (16%), and it is the second most common tumour (13%) among females, after breast cancer (31%) in the Netherlands. In 2007, 11,823 patients were diagnosed with CRC and 4,828 patients died of the disease. The incidence in the Netherlands is relatively high compared to other European countries, and ranks in the top 10.3 Worldwide, CRC accounted for about 1 million of new cancer diagnoses in 2002, representing nearly 10% of all new cancers. It occurs more frequently in the industrialized world. The disease rarely occurs before age 40, and the risk of CRC becomes highest around age 70.1 It is expected that the absolute number of patients with CRC increases with three percent per year in the Netherlands, mainly due to the aging population. Based on this estimation, the incidence of CRC in the Netherlands increases to 14,000 patients in 2015. As a percentage of total mortality, the risk of dying from CRC in the Netherlands is highest around age 60 (about 5%), which is important because it can be seen as an important cause of death. Later in life other causes of death proportionally start to occur more often.
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APA (6th Edition):
Steenbergen, L. (2010). Variation in Occurrence, Management, and Outcome of Colorectal Cancer in the Netherlands, on the Eve of Mass Screening. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19573
Chicago Manual of Style (16th Edition):
Steenbergen, Liza. “Variation in Occurrence, Management, and Outcome of Colorectal Cancer in the Netherlands, on the Eve of Mass Screening.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19573.
MLA Handbook (7th Edition):
Steenbergen, Liza. “Variation in Occurrence, Management, and Outcome of Colorectal Cancer in the Netherlands, on the Eve of Mass Screening.” 2010. Web. 23 Apr 2018.
Vancouver:
Steenbergen L. Variation in Occurrence, Management, and Outcome of Colorectal Cancer in the Netherlands, on the Eve of Mass Screening. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19573.
Council of Science Editors:
Steenbergen L. Variation in Occurrence, Management, and Outcome of Colorectal Cancer in the Netherlands, on the Eve of Mass Screening. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19573
19.
Vorst, M.M.J.
Optimal Furosemide Therapy in Critically Ill infants.
Degree: 2007, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/10162
► textabstractFurosemide as continuous infusion is used in infants after cardiopulmonary bypass (CPB) surgery and during extracorporeal membrane oxygenation (ECMO). The currently used regimens which start…
(more)
▼ textabstractFurosemide as continuous infusion is used in infants after
cardiopulmonary bypass (CPB) surgery and during extracorporeal
membrane oxygenation (ECMO). The currently used regimens which start
with low dose (0.05 - 0.1 mg/kg.hr) may not be optimal in this group
of patients with varying renal function.
In an observational study the pharmacokinetics/pharmacodynamics (PK/
PD) of continuous furosemide therapy were evaluated in infants after
CPB surgery. The study confirmed that the effects of furosemide are
dependent on renal function. Therefore it was hypothesized that
furosemide therapy may be more effective when the infusion is started
at a higher dose. With the data from the observational study a PK/PD
model was developed. The proposed furosemide regimen (loading bolus:
1-2 mg/kg; infusion rate 0.2 mg/kg.hr) by the PK/PD model was
evaluated in infants after CPB surgery. Since adaptation of the
furosemide doses was hardly needed, the proposed regimen seems rational.
In a retrospective study furosemide regimens used in neonates during
ECMO were evaluated. The regimens varied widely in continuous and
intermittent doses. Given the wide variety of doses used, the
regimens might not be optimal. Therefore more standardized and
efficacious dosing regimens should be developed. As CPB and ECMO are
comparable procedures the PK/PD model developed for infants after CPB
surgery might also be applicable for infants on ECMO.
In a prospective study the proposed furosemide regimen (loading
bolus: 1-2 mg/kg; infusion rate 0.2 mg/kg.hr) by the PK/PD model was
evaluated in infants during ECMO. The results suggest that the
proposed furosemide dose was too high, since the dose had to be
decreased in the majority of the patients. Therefore a novel PK/PD
model should be developed for infants on ECMO.
In conclusion the evaluated continuous furosemide regimens are safe
and effective to augment urine production in critically ill infants.
The PK/PD model developed for infants after CPB surgery should be
used with caution in infants treated with ECMO.
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APA (6th Edition):
Vorst, M. M. J. (2007). Optimal Furosemide Therapy in Critically Ill infants. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/10162
Chicago Manual of Style (16th Edition):
Vorst, M M J. “Optimal Furosemide Therapy in Critically Ill infants.” 2007. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/10162.
MLA Handbook (7th Edition):
Vorst, M M J. “Optimal Furosemide Therapy in Critically Ill infants.” 2007. Web. 23 Apr 2018.
Vancouver:
Vorst MMJ. Optimal Furosemide Therapy in Critically Ill infants. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2007. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/10162.
Council of Science Editors:
Vorst MMJ. Optimal Furosemide Therapy in Critically Ill infants. [Doctoral Dissertation]. Erasmus University Medical Center; 2007. Available from: http://hdl.handle.net/1765/10162
20.
Horst, I.W.J.M.
Congenital Diaphragmatic Hernia: A pulmonary vascular point of view.
Degree: Department of Pediatric Surgery, 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19546
► textabstractTreatment of pulmonary hypertension (PH) in neonates is a major challenge on the intensive care unit and involves high morbidity and mortality. However we have…
(more)
▼ textabstractTreatment of pulmonary hypertension (PH) in neonates is a major challenge on the
intensive care unit and involves high morbidity and mortality. However we have
gained considerable insights into the pathophysiology of PH leading to an increasing
number of possible treatment targets. Translation of these novel targets into clinical
application requires multi-centre randomized controlled trials. Furthermore,
considering the underlying pathology is important in therapy choice. New therapies
will not only target vasodilatation, but also reduce vascular remodeling and enhance
postnatal lung development. This review provides an overview of currently available
drugs and promising new targets in the treatment of PH in newborns.
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APA (6th Edition):
Horst, I. W. J. M. (2010). Congenital Diaphragmatic Hernia: A pulmonary vascular point of view. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19546
Chicago Manual of Style (16th Edition):
Horst, I W J M. “Congenital Diaphragmatic Hernia: A pulmonary vascular point of view.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19546.
MLA Handbook (7th Edition):
Horst, I W J M. “Congenital Diaphragmatic Hernia: A pulmonary vascular point of view.” 2010. Web. 23 Apr 2018.
Vancouver:
Horst IWJM. Congenital Diaphragmatic Hernia: A pulmonary vascular point of view. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19546.
Council of Science Editors:
Horst IWJM. Congenital Diaphragmatic Hernia: A pulmonary vascular point of view. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19546
21.
Klerk, Marry.
The Dutch Living Donor Kidney Exchange Program.
Degree: 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19544
► textabstractKidney transplantation is the optimal option for patients with an end-stage renal disease. The first successful transplantation with a living genetically related donor has been…
(more)
▼ textabstractKidney transplantation is the optimal option for patients with an end-stage renal
disease. The first successful transplantation with a living genetically related donor
has been performed since 26 October 1954, when an identical twin transplant was
performed in Boston. In the years that followed, efforts to enable non-twin
transplants unfortunately failed because effective immunosuppression was not yet
available. It took until the early sixties after the discovery of azathiopirine that also
deceased donor kidney transplantations became possible. In the eighties of the last
century the wait time for a kidney transplant was approximately one year. Since
that time the success rate of organ transplantation has significantly improved which
attracted large numbers of transplant candidates. As the number of deceased
organ donors did not increase, the wait time on the list steadily grew and at the
moment patients in most Western countries face wait times up to 5 years before a
deceased donor kidney is offered. Unfortunately an increasing proportion of them
will never be transplanted because their clinical situation deteriorates to such an
extent that they are delisted or die on the wait list. For the Netherlands we estimate
that this proportion is approximately 30%. A strategy to expand the kidney donor
pool includes the use of non-heart beating (NHB) donors. Educational programs in
the Netherlands have resulted in an increase in the number of kidney transplants
derived from NHB donors from almost 20% in the year 2000 to 43% in 2004, while
in the years that followed the numbers of NHB donors stabilized. So the NHB
donors have not led to expansion of the deceased kidney donor pool. Possibly
substitution from heart beating to non heart beating donation procedures took
place, resulting from pressure on the facilities of intensive care units. In the
Netherlands, it has been suggested that the main reason for our failure to increase
the number of deceased organ donors is the lack of donor detection. This is
certainly not the case; both in 2005 and in 2006 almost all potential donors in the
Netherlands (96%) were recognized as such and for the vast majority (86%) our
national donor registry was consulted. The problem is not donor detection but the
high refusal rate by the next of kin, which is inherent to our legal system. Our organ
donation act dictates an opt-in system, and therefore all adult citizens are asked to
register their consent for the use of their organ for transplantation purpose after
death. In the Netherlands approximately 25% of the adults are now registered as
potential donors, 15% have explicitly refused and thus for 60% it remains unknown.
Especially in case of potential donors of the latter category high refusal rates up to
70% haven been found. Apparently next of kin argue that while the possibility was
given to everybody to register as donor, their relative did not do so, therefore they
are unaware of consent and thus reluctant to give permission for donation. We feel
that an opt-out organ…
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APA (6th Edition):
Klerk, M. (2010). The Dutch Living Donor Kidney Exchange Program. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19544
Chicago Manual of Style (16th Edition):
Klerk, Marry. “The Dutch Living Donor Kidney Exchange Program.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19544.
MLA Handbook (7th Edition):
Klerk, Marry. “The Dutch Living Donor Kidney Exchange Program.” 2010. Web. 23 Apr 2018.
Vancouver:
Klerk M. The Dutch Living Donor Kidney Exchange Program. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19544.
Council of Science Editors:
Klerk M. The Dutch Living Donor Kidney Exchange Program. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19544
22.
Reef, Joni.
Adult Consequences of Child Psychopathology.
Degree: 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19531
► textabstractChild and adolescent psychopathology is a great burden to individuals, their families, and to society at large. Children and adolescents with behavioral and emotional problems…
(more)
▼ textabstractChild and adolescent psychopathology is a great burden to individuals, their
families, and to society at large. Children and adolescents with behavioral and
emotional problems suffer from impairments in several domains of functioning,
including difficulties with friendship, self-esteem and school functioning. Parents
often suffer from a lack of knowledge about their child’s problems, which keeps
them from seeking professional help and which causes persistence of problems,
difficulties in school, poor family relations, and concurrent psychopathology.
Society is faced with the consequences of school dropout and higher workload, but
also with costs associated with mental health care, police and the judicial apparatus.
Psychopathology in children not also disturbs children’s functioning, it may also
have long lasting consequences into adulthood. For example, difficulties in
sustaining intimate relationships, in educational success and in building up a
professional career.
Longitudinal studies of the developmental course of psychopathology from
childhood into adulthood are needed to determine which children are at increased
risk of lifetime psychopathology. These children should be given special attention
in prevention and interventional programs by mental health care professionals
working with children and adolescents. This may reduce long-term continuity of
psychopathology.
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APA (6th Edition):
Reef, J. (2010). Adult Consequences of Child Psychopathology. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19531
Chicago Manual of Style (16th Edition):
Reef, Joni. “Adult Consequences of Child Psychopathology.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19531.
MLA Handbook (7th Edition):
Reef, Joni. “Adult Consequences of Child Psychopathology.” 2010. Web. 23 Apr 2018.
Vancouver:
Reef J. Adult Consequences of Child Psychopathology. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19531.
Council of Science Editors:
Reef J. Adult Consequences of Child Psychopathology. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19531
23.
Moelker, Amber.
Stem cell therapy for myocardial infarction.
Degree: Department of Cardiology, 2007, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/10158
► textabstractCoronary heart disease and heart failure continue to be significant burdens to healthcare systems in the Western world and are predicted to become so in…
(more)
▼ textabstractCoronary heart disease and heart failure continue
to be significant burdens to
healthcare systems in the Western world and are predicted to become
so in emerging
economies. Despite mixed results in both experimental and clinical
studies, stem cell
therapy is a promising option for patients suffering from myocardial
infarction or
patients with chronic heart failure after myocardial infarction.
However, many issues
in the field of cellular cardiomyoplasty still need to be resolved.
This thesis describes
the experiments performed in a pre-clinical model in swine with
reperfused
myocardial infarction aiming at addressing several of these issues.
Chapter two of this thesis shows that infarct size in swine can be
measured
accurately with multislice computed tomography, as compared to the
“golden
standard” histology. This study showed that myocardial viability can
be assessed with
multislice computed tomography. Furthermore, since we used magnetic
resonance
imaging in chapter three and four, we showed that for purposes of
infarct size
assessment multislice computed tomography compares well with magnetic
resonance
imaging, which is described in chapter three. Measurement of infarct
size in patients
with acute myocardial infarction is clinically relevant because
infarct size is predictive
of left ventricular function and geometric configuration and, hence,
long-term clinical
outcome. Information on infarct size obtained with multislice
computed tomography
would enhance the diagnostic armamentarium of physicians who lack
access to
cardiac magnetic resonance imaging or encounter patients who have contra
indications to undergo magnetic resonance imaging.
The review of umbilical cord blood derived cells in the fourth
chapter of this
thesis shows a great potential of these cells to regenerate damaged
myocardium. These
cells can easily be obtained in large numbers and are not harvested
from diseased
individuals, therefore they have a great differentiation and
proliferation capacity.
Moreover, they do not raise ethical difficulties question, as do
embryonic stem cells. In
chapter five, the effect of umbilical cord blood cells is assessed
with magnetic
resonance imaging in a porcine model of myocardial infarction. There
was no positive
effect on left ventricular function or infarct size four weeks after
injection of
intracoronary administration of the umbilical cord blood cells, which
what not very
surprising since only a few of the injected cells survived.
Therefore, the immunogenic
status of these cells is not fully understood yet. However, this
study shows that
cultured umbilical cord blood cells should be used with caution when
applied
intracoronary, since their large cell size result in occluded blood
vessels, thereby
causing micro infarctions. Hence, it cannot be excluded that a
possible positive effect
of the umbilical cord blood derived cells was obscured by the
induction of micro
infarctions caused by the mode of administration. Therefore …
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APA (6th Edition):
Moelker, A. (2007). Stem cell therapy for myocardial infarction. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/10158
Chicago Manual of Style (16th Edition):
Moelker, Amber. “Stem cell therapy for myocardial infarction.” 2007. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/10158.
MLA Handbook (7th Edition):
Moelker, Amber. “Stem cell therapy for myocardial infarction.” 2007. Web. 23 Apr 2018.
Vancouver:
Moelker A. Stem cell therapy for myocardial infarction. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2007. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/10158.
Council of Science Editors:
Moelker A. Stem cell therapy for myocardial infarction. [Doctoral Dissertation]. Erasmus University Medical Center; 2007. Available from: http://hdl.handle.net/1765/10158
24.
Houweling, Birgit.
Regulation of Pulmonary Vascular Tone in Health and Disease: Special emphasis on exercise and pulmonary hypertension after myocardial infarction.
Degree: 2007, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/10157
► textabstractHigh bloodpressure in the pulmonary circulation is called pulmonary hypertension (PH). In patients with PH, the balance between vasodilators and vasoconstrictors is disturbed. PH is…
(more)
▼ textabstractHigh bloodpressure in the pulmonary circulation is
called pulmonary hypertension (PH). In patients with PH, the balance
between vasodilators and vasoconstrictors is disturbed. PH is an
important cause of death; it is characterized by elevated levels of
pulmonary artery pressure and pulmonary vascular resistance.
Secondary PH occurs after myocardial infarction and is often the
cause of eventual right ventricular failure. To treat PH it is
important to understand the regulation of the healthy pulmonary
vascular bed and the alterations in PH after myocardial infarction
(MI). In this thesis these questions are investigated in healthy
swine and in swine with post-MI PH. These studies were performed
under resting conditions but also during exercise, because the right
ventricle and the pulmonary circulation are the main determinants of
exercise capacity. By improving the exercise capacity, quality of
live will improve for these patients. In our studies different p!
arameters such as pressure and resistance are being investigated.
The most important findings in this thesis are that endothelin and
nitric oxide are increased during exercise in healthy swine, while
the contribution of prostanoids remains unchanged. After MI, the
balans between vasoldilators and vasoconstrictors is disturbed, which
results in increased pulmonary artery pressure and increased
pulmonary vascular resistance. The contributions of endothelin and
prostacylin are increased. The vasodilating by inhibition of
phosphodiesterase 5 is also increased after MI.
In this thesis some current used therapies for patienst with post-MI
PH (endothelin receptor blockers and phosphodiesterase 5 inhibition)
are used to investigate the pulmonary circulation.
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APA (6th Edition):
Houweling, B. (2007). Regulation of Pulmonary Vascular Tone in Health and Disease: Special emphasis on exercise and pulmonary hypertension after myocardial infarction. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/10157
Chicago Manual of Style (16th Edition):
Houweling, Birgit. “Regulation of Pulmonary Vascular Tone in Health and Disease: Special emphasis on exercise and pulmonary hypertension after myocardial infarction.” 2007. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/10157.
MLA Handbook (7th Edition):
Houweling, Birgit. “Regulation of Pulmonary Vascular Tone in Health and Disease: Special emphasis on exercise and pulmonary hypertension after myocardial infarction.” 2007. Web. 23 Apr 2018.
Vancouver:
Houweling B. Regulation of Pulmonary Vascular Tone in Health and Disease: Special emphasis on exercise and pulmonary hypertension after myocardial infarction. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2007. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/10157.
Council of Science Editors:
Houweling B. Regulation of Pulmonary Vascular Tone in Health and Disease: Special emphasis on exercise and pulmonary hypertension after myocardial infarction. [Doctoral Dissertation]. Erasmus University Medical Center; 2007. Available from: http://hdl.handle.net/1765/10157
25.
Tuyl, Bas.
Videocapsule Endoscopy: Fiction becoming fact.
Degree: 2007, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/10156
► textabstractThe recent introduction of videocapsule endoscopy has provided gastroenterologists a complete and simple endoscopic technique for endoscopic evaluation of the entire small intestine. Previously, the…
(more)
▼ textabstractThe recent introduction of videocapsule endoscopy has provided gastroenterologists
a complete and simple endoscopic technique for endoscopic evaluation of the entire
small intestine. Previously, the proximal part of the small intestine could be examined
using push enteroscopy and the terminal ileum could be evaluated at ileocolonoscopy.
Only an intra-operative enteroscopy offered the possibility to examine the entire small
intestine. The latter is however a very invasive procedure as a laparotomy is necessary
to allow the surgeon to move the small bowel over the endoscope. Videocapsule
endoscopy (VCE) is a new technique to examine the small intestine in a non-invasive
way. A capsule with a length of 26 mm. and a width of 11 mm. is swallowed by the
patient and is propelled by small intestinal peristalsis. It obtains two digital images
per second which are transmitted to a data recorder. At the end of the procedure the
images are downloaded to a working station where they can be reviewed as a movie.
The first papers on the results of VCE were very promising. The entire small intestine
was examined in 85% of the patients and a diagnosis was established in 55-85% of
the patients. The diagnostic yield in these first studies could be overestimated by the
initial strong case selection, and the clinical relevance of the VCE fi ndings remained
unclear. It can be expected that the proportion of patients with clinically relevant VCE
findings will be lower when the technique is more widely available. Capsule endoscopy
nevertheless appears to be superior to push enteroscopy and radiological examination
of the small intestine. Further research is needed on the optimal preparation, clinical
consequences of VCE findings and possible other indications for VCE.
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APA (6th Edition):
Tuyl, B. (2007). Videocapsule Endoscopy: Fiction becoming fact. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/10156
Chicago Manual of Style (16th Edition):
Tuyl, Bas. “Videocapsule Endoscopy: Fiction becoming fact.” 2007. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/10156.
MLA Handbook (7th Edition):
Tuyl, Bas. “Videocapsule Endoscopy: Fiction becoming fact.” 2007. Web. 23 Apr 2018.
Vancouver:
Tuyl B. Videocapsule Endoscopy: Fiction becoming fact. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2007. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/10156.
Council of Science Editors:
Tuyl B. Videocapsule Endoscopy: Fiction becoming fact. [Doctoral Dissertation]. Erasmus University Medical Center; 2007. Available from: http://hdl.handle.net/1765/10156
26.
Swarte, Renate.
The Clinical Value of Intensive Monitoring in Term Asphyxiated Newborns.
Degree: Department of Pediatrics, 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19509
► textabstractPerinatal asphyxia is an important cause of brain injury. It may lead to hypoxic-ischaemic encephalopathy (HIE) which occurs in one to six of every 1000…
(more)
▼ textabstractPerinatal asphyxia is an important cause of brain injury. It may
lead to hypoxic-ischaemic encephalopathy (HIE) which occurs in one to
six of every 1000 full term births. The risk of death or severe handicap is
0.5-2.0 out of 1000. Following intrapartum asphyxia cerebral hypoperfusion
in combination with hypoxia produces characteristic neuropathological
changes and related clinical signs. After the primary insult
there is a thirty minutes period of reperfusion characterized by the partial
recovery of cell and metabolic processes. This is followed by a latent
phase which may last up to six hours. In this phase oxidative metabolism
(near) normalizes (shown by MRspectroscopy) but EEG activity is depressed
and the blood flow is likely to be reduced. Secondary energy failure
and secondary hyperperfusion (‘luxury perfusion’) may occur in the
neonatal brain within 6-15 hours after an acute ischaemic insult, marked
by the acute onset of seizures (peaking at about 12 hours post insult).
Excitotoxins accumulate in the cell and cell death may take 72 hours to
completion. The infant’s gestational age and thus the maturational
stage of the brain, as well as type, severity and duration of the insult are
determinants of the brain injury. During the insult there is redistribution
of blood flow to the brain, heart and adrenals. Our current understanding
of perinatal asphyxia is based on animal experiments. Different and
mixed etiologies lead to a range of post asphyxial patterns, usually subdivided
into different patterns; acute, chronic or a combination of these
two. With chronic, possibly repetitive insults, lesions are predominantly
seen in (sub)cortical structures. This has been named watershed injury
for its classical distribution along the borderzones between the major
pial arteries, sparing thalamus and basal ganglia. From the literature it
appears that watershed injury is observed most frequently in context
of term birth asphyxia. In acute and (near) total asphyxia the damage is
mostly to the thalami, basal ganglia, hippocampus, cerebellum, brain
stem and specific areas of the neocortex like the rolandic, calcarine and
insular cortex.
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APA (6th Edition):
Swarte, R. (2010). The Clinical Value of Intensive Monitoring in Term Asphyxiated Newborns. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19509
Chicago Manual of Style (16th Edition):
Swarte, Renate. “The Clinical Value of Intensive Monitoring in Term Asphyxiated Newborns.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19509.
MLA Handbook (7th Edition):
Swarte, Renate. “The Clinical Value of Intensive Monitoring in Term Asphyxiated Newborns.” 2010. Web. 23 Apr 2018.
Vancouver:
Swarte R. The Clinical Value of Intensive Monitoring in Term Asphyxiated Newborns. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19509.
Council of Science Editors:
Swarte R. The Clinical Value of Intensive Monitoring in Term Asphyxiated Newborns. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19509
27.
Saat, Tanja.
Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury: Nutritionele en cellulaire preconditionering tegen ischemie-reperfusie schade.
Degree: 2017, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/101490
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APA (6th Edition):
Saat, T. (2017). Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury: Nutritionele en cellulaire preconditionering tegen ischemie-reperfusie schade. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/101490
Chicago Manual of Style (16th Edition):
Saat, Tanja. “Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury: Nutritionele en cellulaire preconditionering tegen ischemie-reperfusie schade.” 2017. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/101490.
MLA Handbook (7th Edition):
Saat, Tanja. “Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury: Nutritionele en cellulaire preconditionering tegen ischemie-reperfusie schade.” 2017. Web. 23 Apr 2018.
Vancouver:
Saat T. Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury: Nutritionele en cellulaire preconditionering tegen ischemie-reperfusie schade. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2017. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/101490.
Council of Science Editors:
Saat T. Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury: Nutritionele en cellulaire preconditionering tegen ischemie-reperfusie schade. [Doctoral Dissertation]. Erasmus University Medical Center; 2017. Available from: http://hdl.handle.net/1765/101490
28.
Wijk, Kees.
De Service Care Chain: De invloed van service en HRM op de realisering van vraaggerichte dienstverlening door zorgorganisaties.
Degree: 2007, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/10147
► textabstractHealthcare for people with a physical, mental or psychological handicap has been developing momentum over the last few years. A series of changes in legislations…
(more)
▼ textabstractHealthcare for people with a physical, mental or psychological handicap has been developing momentum over the last few years. A series of changes in legislations and management decisions have
brought about to enormous changes and not always without good reason. The structure and provisions of the AWBZ121 had become too large and consequently too expensive. Times changed and the
old laws had become antiquated. A supply orientated system did not meet today’s demands and had
to give way to a system operating to meet the needs of today’s clients. This implies fundamental
changes to the financial structure. It also necessitates breaking down the barriers dividing AWBZ
departments and the stimulation of competition between the companies of care and between the insurance suppliers. These developments go hand in hand with a strengthening client position.
Advisors/Committee Members: Erasmus School of Health Policy & Management (ESHPM), Erasmus School of Health Policy & Management (ESHPM).
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APA (6th Edition):
Wijk, K. (2007). De Service Care Chain: De invloed van service en HRM op de realisering van vraaggerichte dienstverlening door zorgorganisaties. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/10147
Chicago Manual of Style (16th Edition):
Wijk, Kees. “De Service Care Chain: De invloed van service en HRM op de realisering van vraaggerichte dienstverlening door zorgorganisaties.” 2007. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/10147.
MLA Handbook (7th Edition):
Wijk, Kees. “De Service Care Chain: De invloed van service en HRM op de realisering van vraaggerichte dienstverlening door zorgorganisaties.” 2007. Web. 23 Apr 2018.
Vancouver:
Wijk K. De Service Care Chain: De invloed van service en HRM op de realisering van vraaggerichte dienstverlening door zorgorganisaties. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2007. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/10147.
Council of Science Editors:
Wijk K. De Service Care Chain: De invloed van service en HRM op de realisering van vraaggerichte dienstverlening door zorgorganisaties. [Doctoral Dissertation]. Erasmus University Medical Center; 2007. Available from: http://hdl.handle.net/1765/10147
29.
Wolters, Tineke.
Improving Screening Strategies for Prostate Cancer.
Degree: Department of Urology, 2010, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/19434
► textabstractTh is thesis describes research on screening for prostate cancer. To improve understanding of the thesis, some background information will be provided in this introduction.…
(more)
▼ textabstractTh is thesis describes research on screening for prostate cancer. To improve understanding of
the thesis, some background information will be provided in this introduction. First, a short
description of the prostate and of prostate cancer will be given in Chapter 1, followed by more
detailed background information on screening for prostate cancer in Chapter 2. Th e fi nal part
of this introduction, Chapter 3, will outline the scope of this thesis.
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APA (6th Edition):
Wolters, T. (2010). Improving Screening Strategies for Prostate Cancer. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/19434
Chicago Manual of Style (16th Edition):
Wolters, Tineke. “Improving Screening Strategies for Prostate Cancer.” 2010. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/19434.
MLA Handbook (7th Edition):
Wolters, Tineke. “Improving Screening Strategies for Prostate Cancer.” 2010. Web. 23 Apr 2018.
Vancouver:
Wolters T. Improving Screening Strategies for Prostate Cancer. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2010. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/19434.
Council of Science Editors:
Wolters T. Improving Screening Strategies for Prostate Cancer. [Doctoral Dissertation]. Erasmus University Medical Center; 2010. Available from: http://hdl.handle.net/1765/19434
30.
Velde, Nathalie.
Falls in old age: pills, the heart and beyond: Withdrawal of drugs and screening for cardiovascular causes in older fallers.
Degree: 2007, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/10146
► textabstractFall incidents are common in old age, with a rising injury rate with increasing age. Falling is not a diagnosis per se, but a symptom…
(more)
▼ textabstractFall incidents are common in old age, with a rising injury rate with
increasing age. Falling
is not a diagnosis per se, but a symptom that can result from a
number of diseases and abnormalities.
However, even though there are abundant studies addressing possible
causes
of fall incidents in older persons, there are still quite a few
unresolved questions. In this
thesis, we focus on two groups of (possible) fall-risk factors.
First, we address cardiovascular
risk factors for falls and second, we elude on the effects of
withdrawal of drugs that are
known in the literature to increase fall risk.
Chapter 1 gives a general introduction to this thesis. Chapter 2
contains a selection of
case reports regarding drug-related falls. These patients prompted us
to conduct a prospective
cohort study on this topic. In all these patients, falling was
attributed to the use of
certain drugs and fall incidents ceased after withdrawal of these drugs.
Chapter 3 focuses on cardiovascular determinants of falls. In chapter
3.1 the association
between echocardiographic abnormalities and fall incidents was
investigated in a
prospective cohort of geriatric outpatients. It is generally accepted
that certain structural
cardiac abnormalities, like for example aortic valve stenosis, mitral
valve regurgitation
and pulmonary hypertension can result in syncopal events. We showed
that there was a
significant association with fall incidents for both valvular
regurgitations and pulmonary
hypertension. Fall risk increased with increasing severity of the
abnormality. No relation
was found between aortic valve stenosis and fall incidents, probably
due to a lack of moderate
and severe stenoses in our follow-up group. In chapter 3.2 the
association between
left ventricular systolic function, as measured with
echocardiography, and fall risk was examined
in the Rotterdam study. The risk of a serious fall incident during
follow-up was
significantly higher if left ventricular ejection fraction was
impaired. In chapter 3.3 the
optimal measurement method of orthostatic hypotension in relation to
falls was studied.
Within a cohort of geriatric outpatients it was investigated which
time average of continuous-
finger-blood-pressure measurement showed the best association between
OH and
falls. This was also compared with conventional sphygmomanometer
measurements. The
best association was found when using 5-second averages of the
continuous measurement
method. Since the aetiology of falls is often multifactorial,
orthostatic hypotension
and falls remained poorly correlated, irrespective of the method or
time average that was
applied.
The studies described in chapter 4 concern the relationship between
the use of fall-riskincreasing
drugs and falls, including the pathway leading to these fall
incidents. In chapter
4.1 fall risk after withdrawal of certain drugs is tested in a cohort
of geriatric outpatients.
Several drugs have been associated with an increased fall risk, but
it is not yet known…
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Velde, N. (2007). Falls in old age: pills, the heart and beyond: Withdrawal of drugs and screening for cardiovascular causes in older fallers. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/10146
Chicago Manual of Style (16th Edition):
Velde, Nathalie. “Falls in old age: pills, the heart and beyond: Withdrawal of drugs and screening for cardiovascular causes in older fallers.” 2007. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 23, 2018.
http://hdl.handle.net/1765/10146.
MLA Handbook (7th Edition):
Velde, Nathalie. “Falls in old age: pills, the heart and beyond: Withdrawal of drugs and screening for cardiovascular causes in older fallers.” 2007. Web. 23 Apr 2018.
Vancouver:
Velde N. Falls in old age: pills, the heart and beyond: Withdrawal of drugs and screening for cardiovascular causes in older fallers. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2007. [cited 2018 Apr 23].
Available from: http://hdl.handle.net/1765/10146.
Council of Science Editors:
Velde N. Falls in old age: pills, the heart and beyond: Withdrawal of drugs and screening for cardiovascular causes in older fallers. [Doctoral Dissertation]. Erasmus University Medical Center; 2007. Available from: http://hdl.handle.net/1765/10146
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Open Access Theses and Dissertations
