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1.
AL-Hamed, Arwa Abdulaziz.
THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION,
ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN
WITH CHRONIC KIDNEY DISEASE.
Degree: PhD, Nursing, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292
► The aim of this study was to examine the relationship between executive function (EF), adaptive function (AF), academic achievement (AA), and to identify their relationship…
(more)
▼ The aim of this study was to examine the relationship
between executive function (EF), adaptive function (AF), academic
achievement (AA), and to identify their relationship with health
related quality of life (HRQOL) in children with chronic kidney
disease (CKD). A cross-sectional design was used for this secondary
data analysis of children from across the United States and Canada
with mild to moderate CKD who receive care at hospitals associated
with the Chronic Kidney Disease in Children study (CKiD). Data were
collected using the Conner’s Continuous Performance Testing-II,
Behavior Rating Inventory of Executive Functioning (BRIEF),
Behavior Assessment System for Children-2, Wechsler Individual
Achievement Test-II-Abbreviated and Pediatric Quality of Life
Inventory. The children (N= 243) were mostly between 13 to 17 years
of age (45%), 75 %, were Caucasian and 59% were male. A majority of
the mothers (55%) had some college or baccalaureate degree and a
household income above 31,000% annually (74%). The majority of
children (76%) had a type of non-glomerular CKD; 50 % had CKD Stage
2 & 3. Children with CKD had lower HRQOL compared to their
healthy peers with
school functioning being the most affected area.
Most scores for the EF, AF, and AA placed children with CKD within
an age-appropriate range. However, there was a high percentage of
children (23%- 43%) scoring more than 1 SD below the mean for EF,
AF, and AA, indicating an increased risk for neurocognitive
impairments. The hierarchical multiple regression analysis
indicated that EF, AF, and AA accounted for 36 % of the variance in
HRQOL but increased to 40% of the variance with the addition of
covariates. Poor EF (Global Executive Composite), AF (Internalizing
Problems [e.g. depressive symptoms, and anxiety]), and AA
significantly predicted lower HRQOL. With the addition of
covariates, only EF and AF remained significant, while high
maternal education significantly predicted higher HRQOL, and anemia
significantly predicted lower HRQOL. While the mediation effect of
AA on the relationship between EF and HRQOL was not supported in
this study, the results suggest that AF (Internalizing Problems)
partially mediated the relationship between EF and HRQOL. This
study underscores the need for an interdisciplinary approach
(
school nurses, teachers, psychologists, pediatric nephrologist) to
tailor interventions that optimize EF, AF, and AA, and enhance
HRQOL in children with mild to moderate CKD.
Advisors/Committee Members: Toly , Valerie (Committee Chair).
Subjects/Keywords: Health Care; Nursing
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APA ·
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MLA ·
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APA (6th Edition):
AL-Hamed, A. A. (2019). THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION,
ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN
WITH CHRONIC KIDNEY DISEASE. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292
Chicago Manual of Style (16th Edition):
AL-Hamed, Arwa Abdulaziz. “THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION,
ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN
WITH CHRONIC KIDNEY DISEASE.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292.
MLA Handbook (7th Edition):
AL-Hamed, Arwa Abdulaziz. “THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION,
ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN
WITH CHRONIC KIDNEY DISEASE.” 2019. Web. 02 Mar 2021.
Vancouver:
AL-Hamed AA. THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION,
ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN
WITH CHRONIC KIDNEY DISEASE. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292.
Council of Science Editors:
AL-Hamed AA. THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION,
ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN
WITH CHRONIC KIDNEY DISEASE. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292
2.
Hiznay, James Matthew.
Molecular Analyses of DDX41 in the Spliceosome and Myeloid
Neoplasms.
Degree: PhD, Molecular Medicine, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859
► Within the past decade, links between RNA splicing and myeloid neoplasms have emerged in the basic and clinical literature. DDX41 is a putative DEAD-box RNA…
(more)
▼ Within the past decade, links between RNA splicing and
myeloid neoplasms have emerged in the basic and clinical
literature. DDX41 is a putative DEAD-box RNA helicase involved in
the function of the spliceosome. Like several spliceosomal factors,
mutations in DDX41 are observed in myelodysplastic syndrome (MDS).
Uniquely, heterozygous frameshift DDX41 mutations can occur in the
germ line of MDS patients with or without somatic missense
mutations in the other allele. We cataloged MDS patients with
somatic and germ line DDX41 mutations. Relative to MDS patients
lacking a DDX41 mutation, our patient cohort had fewer co-mutations
in epigenetic modulators, but co-mutations in DNA repair factors
were increased. We examined the role of DDX41 perturbations on gene
expression and splicing. We found that DDX41 binds to pre-mRNAs
near splice sites and to some spliceosomal snRNAs, notably U2 and
U12. Recombinant DDX41 protein was shown to have double-stranded
RNA unwinding and ATP hydrolytic activities. Recombinant protein
with the recurrent somatic mutation p.Arg525His (p.R525H) bound RNA
about fourfold better but unwound RNA about fourfold slower than
wild type. Nuclear extract created from DDX41-deficient leukemic
cells spliced RNA approximately threefold slower than nuclear
extract derived from HeLa cells. In cell lines, both knockdown of
DDX41 and expression of p.R525H mutant DDX41 led to changes in
splicing and expression in a variety of genes. These changes were
similar to the changes seen in cell lines with mutations in the
MDS-associated splicing factors SF3B1 and U2AF1. Global splicing
analyses suggested that DDX41 delays intron removal, perhaps as
part of a proofreading step, while the p.R525H mutant has a
dominant negative stimulatory effect on splicing. We also saw that
DDX41 perturbations affected the levels of many other spliceosomal
factors, likely producing a cellular environment permissive for
aberrant splicing events.
Advisors/Committee Members: Padgett, Richard (Advisor), Luse, Donal (Committee Chair).
Subjects/Keywords: Biochemistry; Genetics; Health Sciences; Molecular Biology; Oncology; Biomedical Research; DDX41; splicing; MDS
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APA (6th Edition):
Hiznay, J. M. (2019). Molecular Analyses of DDX41 in the Spliceosome and Myeloid
Neoplasms. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859
Chicago Manual of Style (16th Edition):
Hiznay, James Matthew. “Molecular Analyses of DDX41 in the Spliceosome and Myeloid
Neoplasms.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859.
MLA Handbook (7th Edition):
Hiznay, James Matthew. “Molecular Analyses of DDX41 in the Spliceosome and Myeloid
Neoplasms.” 2019. Web. 02 Mar 2021.
Vancouver:
Hiznay JM. Molecular Analyses of DDX41 in the Spliceosome and Myeloid
Neoplasms. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859.
Council of Science Editors:
Hiznay JM. Molecular Analyses of DDX41 in the Spliceosome and Myeloid
Neoplasms. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859
3.
Yang, Lingyu.
In-Situ Synthesis of Well-Defined Silver Nanoparticles in
Water Soluble Polymer Matrix.
Degree: MSs, Macromolecular Science and Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208
► In this thesis, spin-coated pure PVA films and PVA/PVP blend films were used as solid-state polymer matrix, and embedded silver nanoparticles were synthesized by ultraviolet…
(more)
▼ In this thesis, spin-coated pure PVA films and PVA/PVP
blend films were used as solid-state polymer matrix, and embedded
silver nanoparticles were synthesized by ultraviolet (UV)
irradiation method and heating method via in situ reaction. PVA and
PVP serve as polyol reductant and stabilizer, respectively.
UV-visible spectroscopy was used to characterize the effect of
precursor concentration, polymer blend content, and reaction
conditions on the size and distribution of silver nanoparticles
(AgNPs). The morphology of AgNPs and polymer network were observed
by transmission electron microscopy (TEM). The Ag/PVA and
Ag/PVA/PVP nanocomposite films were successfully prepared by UV
light and thermal-induced reduction of the metal precursor, silver
nitrate (AgNO3), and growth of the AgNPs directly in the
solid-state polymer film. AgNPs with different sizes ranging from 3
to 15 nm and narrow distribution were synthesized by changing the
reaction conditions. Therefore, these synthesis methods are simple
in operation and fast in reaction.
Advisors/Committee Members: Zhu, Lei (Committee Chair).
Subjects/Keywords: Nanoscience
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yang, L. (2019). In-Situ Synthesis of Well-Defined Silver Nanoparticles in
Water Soluble Polymer Matrix. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208
Chicago Manual of Style (16th Edition):
Yang, Lingyu. “In-Situ Synthesis of Well-Defined Silver Nanoparticles in
Water Soluble Polymer Matrix.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208.
MLA Handbook (7th Edition):
Yang, Lingyu. “In-Situ Synthesis of Well-Defined Silver Nanoparticles in
Water Soluble Polymer Matrix.” 2019. Web. 02 Mar 2021.
Vancouver:
Yang L. In-Situ Synthesis of Well-Defined Silver Nanoparticles in
Water Soluble Polymer Matrix. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208.
Council of Science Editors:
Yang L. In-Situ Synthesis of Well-Defined Silver Nanoparticles in
Water Soluble Polymer Matrix. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208
4.
Samorezov, Julia Elizabeth.
Hydrogels with Controlled Physical and Biochemical
Properties to Direct Cell Behavior for Applications in Bone Tissue
Engineering.
Degree: PhD, Biomedical Engineering, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088
► Tissue engineered bone grafts using biomaterials, autologous cells and bioactive factors seek to address the clinical need for replacement bone tissue to treat musculoskeletal injuries.…
(more)
▼ Tissue engineered bone grafts using biomaterials,
autologous cells and bioactive factors seek to address the clinical
need for replacement bone tissue to treat musculoskeletal injuries.
This dissertation aimed to use hydrogel biomaterial scaffolds to
present either biochemical signals or patterns of physical
properties to influence the behavior of cells with known osteogenic
potential, with the ultimate goal of expanding knowledge of the
cells’ responses to such signals and developing instructive
biomaterials for bone regeneration. Human adipose-derived stem
cells (hASCs) were used because of their known capacity for
osteogenic differentiation, but there are conflicting data on their
response to specific potentially osteogenic soluble factors. To
address this, dexamethasone and bone morphogenetic protein-2
(BMP-2) were examined for their effects on osteogenic
differentiation of hASCs from three donors in 2D culture and in 3D
methacrylated gelatin (GelMA) hydrogels. Culture medium with a
lower calcium concentration than standard DMEM was shown to be
beneficial in revealing these effects. Media supplementation with
BMP-2 did not improve hASC osteogenesis. Dexamethasone was shown to
be highly osteogenic, but the addition of BMP-2 to culture media
inhibited this dexamethasone-driven hASC osteogenic
differentiation. It was next examined if sustained, localized
presentation of BMP-2 could enhance its osteogenic potential
compared to exogenous presentation from culture medium. When BMP-2
was mixed into GelMA hydrogels prior to crosslinking, approximately
one third of the loaded growth factor was retained in the hydrogels
for seven weeks. Delivery from the hydrogel did improve BMP-2
bioactivity, leading to statistically increased calcium deposition
compared to similar amounts of growth factor supplied exogenously
in culture medium. Lastly, a dual-crosslinked alginate hydrogel
system was developed to spatially control hydrogel physical
properties or presentation of covalently coupled cell adhesive
peptides. Changes in biomaterial stiffness and swelling
significantly affected preosteoblast cell proliferation, and
spatial control over RGD cell adhesion peptide presentation
directed both cell adhesion and proliferation. This system can
easily be applied to control the spatial presentation of osteogenic
signals to hASCs, providing a platform to study cell response to
patterned physical and biochemical signals or serving as an
instructive biomaterial to guide hASC osteogenesis.
Advisors/Committee Members: Alsberg, Eben (Advisor).
Subjects/Keywords: Biomedical Engineering
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Samorezov, J. E. (2015). Hydrogels with Controlled Physical and Biochemical
Properties to Direct Cell Behavior for Applications in Bone Tissue
Engineering. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088
Chicago Manual of Style (16th Edition):
Samorezov, Julia Elizabeth. “Hydrogels with Controlled Physical and Biochemical
Properties to Direct Cell Behavior for Applications in Bone Tissue
Engineering.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088.
MLA Handbook (7th Edition):
Samorezov, Julia Elizabeth. “Hydrogels with Controlled Physical and Biochemical
Properties to Direct Cell Behavior for Applications in Bone Tissue
Engineering.” 2015. Web. 02 Mar 2021.
Vancouver:
Samorezov JE. Hydrogels with Controlled Physical and Biochemical
Properties to Direct Cell Behavior for Applications in Bone Tissue
Engineering. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088.
Council of Science Editors:
Samorezov JE. Hydrogels with Controlled Physical and Biochemical
Properties to Direct Cell Behavior for Applications in Bone Tissue
Engineering. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088
5.
Bury, Luke Andrew Dascenzo.
Examining Dynamic Aspects of Presynaptic Terminal Formation
via Live Confocal Microscopy.
Degree: PhD, Pharmacology, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355
► To create a presynaptic terminal, molecular signaling events must be orchestrated within a number of subcellular compartments. In the soma, presynaptic proteins need to be…
(more)
▼ To create a presynaptic terminal, molecular signaling
events must be orchestrated within a number of subcellular
compartments. In the soma, presynaptic proteins need to be
synthesized, packaged together, and attached to microtubule motors
for shipment through the axon. Within the axon, transport of
presynaptic packages is regulated in order to ensure that
developing synapses receive an adequate supply of components. At
individual axonal sites, extracellular interactions must be
translated into intracellular signals that can incorporate mobile
transport vesicles into the nascent presynaptic terminal. Even once
the initial recruitment process is complete, the components and
subsequent functionality of presynaptic terminals need to
constantly be remodeled. Perhaps most remarkably, all of these
processes need to be coordinated in space and time. In this
dissertation, I will discuss how these dynamic cellular processes
occur in neurons of the central nervous system in order to generate
presynaptic terminals in the brain, and describe experiments to
further elucidate these mechanisms.
Advisors/Committee Members: Sabo, Shasta (Advisor), Siegel, Ruth (Committee Chair).
Subjects/Keywords: Neurosciences; Neurobiology; Biomedical Research; Developmental Biology; presynaptic; synaptogenesis; synapse formation; axonal transport; live imaging; confocal microscopy; neuroligin; neurexin
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bury, L. A. D. (2015). Examining Dynamic Aspects of Presynaptic Terminal Formation
via Live Confocal Microscopy. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355
Chicago Manual of Style (16th Edition):
Bury, Luke Andrew Dascenzo. “Examining Dynamic Aspects of Presynaptic Terminal Formation
via Live Confocal Microscopy.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355.
MLA Handbook (7th Edition):
Bury, Luke Andrew Dascenzo. “Examining Dynamic Aspects of Presynaptic Terminal Formation
via Live Confocal Microscopy.” 2015. Web. 02 Mar 2021.
Vancouver:
Bury LAD. Examining Dynamic Aspects of Presynaptic Terminal Formation
via Live Confocal Microscopy. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355.
Council of Science Editors:
Bury LAD. Examining Dynamic Aspects of Presynaptic Terminal Formation
via Live Confocal Microscopy. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355
6.
Chen, Yang.
DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE
RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY.
Degree: PhD, EECS - Computer Engineering, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642
► With the deluge of biomedical data, developing computational approaches for data analysis and interrogation has become a key step in translational biomedical research. It is…
(more)
▼ With the deluge of biomedical data, developing
computational approaches for data analysis and interrogation has
become a key step in translational biomedical research. It is
critical to leverage existing data to ask the right question and
design algorithms for specific biomedical applications. This
dissertation proposes a domain knowledge guided strategy for data
gathering, data fusion and algorithm design in solving specific
biomedical problems. This strategy is demonstrated in three
distinct application contexts.The first application is retrieving
disease manifestation images from the web for supporting patients'
self-education and decision making. The challenge is three-fold:
heterogeneous irrelevant web images need to be filtered; the
positive examples of disease images contain diverse objects and
complex backgrounds; and large amounts of manual efforts in
generating training data are unaffordable. Based on a key
observation that detecting disease-affected abnormal organs may
greatly reduce the manual labeling efforts, our approach extracts
the disease-organ semantic relationships from ontologies to guide
the organ detection with pre-trained detectors. Comparing with a
standard supervised method, our approach improved the average
precision by 5% while reduced the manual efforts by 85%.The
second application is developing disease-specific models to detect
genetic basis for human diseases. We first develop a cross-species
genetic network analysis approach to study the host-pathogen
interactions in parasitic infectious diseases and predict disease
associated genes. This approach was applied on malaria and
demonstrated useful in guiding anti-malaria drug discovery. In the
second phenome-driven approach, we explore a new disease phenotype
data source in medical ontologies to construct the Disease
Manifestation Network (DMN), and integrate multiple phenotype
networks with genetic networks to predict genes. An application of
this approach on Crohn's disease demonstrated the translational
potential of the predicted genes in drug discovery. The third
approach is identifying the mutual comorbidity for colorectal
cancer and obesity in the comorbidity network to detect genetic
basis for the link between the two diseases.The last application is
drug repositioning based on combining disease genetics and mouse
phenotype data. Disease associated genes have the potential to
guide drug discovery. On the other hand, the mouse phenotypes
provide knowledge on gene functions, which is impossible to be
obtained in human. Our approach first identifies disease-specific
mouse phenotypes using well-studied disease genes, and then search
all FDA-approved drugs for the candidates that share similar mouse
phenotype profiles with the disease.The approach was applied to
predict drugs for Parkinson's disease, and achieved significant
improvements comparing with a state-of-art approach based on mouse
phenotype data.In summary, this dissertation demonstrates the
effectiveness of computational algorithms in translational
biomedical research. It…
Advisors/Committee Members: Guo-qiang, Zhang (Committee Chair), Rong, Xu (Advisor).
Subjects/Keywords: Computer Science; Biomedical Research; Computer Engineering; computational approach; translational biomedical research; image retrieval; disease gene prediction; drug repositioning
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chen, Y. (2015). DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE
RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642
Chicago Manual of Style (16th Edition):
Chen, Yang. “DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE
RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642.
MLA Handbook (7th Edition):
Chen, Yang. “DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE
RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY.” 2015. Web. 02 Mar 2021.
Vancouver:
Chen Y. DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE
RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642.
Council of Science Editors:
Chen Y. DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE
RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642
7.
Vithayathil, Joseph.
Developmental and Post-natal Roles for ERK1/2 Signaling in
the Hippocampus.
Degree: PhD, Neurosciences, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090
► The ERK/MAPK pathway is an intracellular signaling pathway that mediates many cellular functions. Mutations in the different elements of this pathway lead to a variety…
(more)
▼ The ERK/MAPK pathway is an intracellular signaling
pathway that mediates many cellular functions. Mutations in the
different elements of this pathway lead to a variety of congenital
disorders termed neuro-cardio-facial-cutaneous syndromes (NCFC).
These disorders result in many overlapping features including
various levels of intellectual disability and cognitive function.
In addition, dysregulation of the ERK/MAPK pathway has been
implicated in other cognitive and behavioral disorders such as
autism, schizophrenia and major depression. Understanding the role
of this pathway during development and maturation of the brain will
provide critical insight into the pathophysiology of these
disorders.The ERK/MAPK pathway has previously been shown to
regulate proliferation of neural progenitors during cortical
development. Furthermore, pharmacologic
studies inhibiting the
ERK/MAPK pathway resulted in impaired synaptic plasticity and
spatial memory. These
studies have identified potential roles for
ERK signaling during development and neurophysiologic functions in
the hippocampus. The hippocampus is a critical mediator of memory
formation and hippocampal volume is altered in various cognitive
and behavioral disorders. An important question that remains to be
answered is identifying the relative contributions from
developmental and post-natal dysregulation of the MAPK pathway in
the hippocampus as it relates to the pathophysiology of cognitive
deficits observed in NCFC and related syndromes.In examining the
development of the hippocampus, we observe that loss of both ERK1
and ERK2 isoforms impairs morphogenesis of the hippocampus
resulting in a dentate gyrus that is 1/3 the size of a normal
dentate gyrus by post-natal day 10. Furthermore, this phenotype is
due to the precocious maturation of radial glial cells and
depletion of progenitor populations in the germinal zones that
generate the granule cells of the dentate gyrus. Interestingly, the
presence of ERK1 is sufficient for normal development of the
hippocampus, as knockouts of ERK2 alone do not affect hippocampal
morphogenesis. Finally, to examine possible post-natal effects from
loss of ERK2 we utilized the developmental ERK2 knockout mice and a
post-natal ERK2 knockout mouse to show that the loss of ERK2 does
not result in major changes to memory or long-term potentiation in
the hippocampus. Interestingly, the post-natal knockout of ERK2 can
affect recognition memory and causes delayed spatial learning, but
LTP remains intact. These findings show that ERK1 is sufficient for
normal development and memory functions of the hippocampus.
Furthermore, developmental knockouts of ERK2 appear to perform
better than post-natal knockouts of ERK2 in some memory retention
tasks suggesting that developmental adaptions from loss of ERK
signaling may ameliorate necessity for ERK signaling. These
findings highlight the necessity of examining the effects of
chronic dysregulation of signaling pathways that regulate
hippocampal function, as these phenotypes may be vastly different
from…
Advisors/Committee Members: Deneris, Evan (Committee Chair), Landreth, Gary (Advisor).
Subjects/Keywords: Biomedical Research; Molecular Biology; dentate gyrus development; neurogenesis; MAPK pathway; NCFC syndromes; synaptic plasticity; memory formation
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vithayathil, J. (2015). Developmental and Post-natal Roles for ERK1/2 Signaling in
the Hippocampus. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090
Chicago Manual of Style (16th Edition):
Vithayathil, Joseph. “Developmental and Post-natal Roles for ERK1/2 Signaling in
the Hippocampus.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090.
MLA Handbook (7th Edition):
Vithayathil, Joseph. “Developmental and Post-natal Roles for ERK1/2 Signaling in
the Hippocampus.” 2015. Web. 02 Mar 2021.
Vancouver:
Vithayathil J. Developmental and Post-natal Roles for ERK1/2 Signaling in
the Hippocampus. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090.
Council of Science Editors:
Vithayathil J. Developmental and Post-natal Roles for ERK1/2 Signaling in
the Hippocampus. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090
8.
Bakhshiani, Mehran.
A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM
FORBROADBAND DIELECTRIC SPECTROSCOPY.
Degree: PhD, EECS - Electrical Engineering, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857
► This project has developed two integrated microsystems fabricated in a 0.35-µm two-poly four-metal RF CMOS process for miniaturized broadband dielectric spectroscopy. In particular, first, a…
(more)
▼ This project has developed two integrated microsystems
fabricated in a 0.35-µm two-poly four-metal RF CMOS process for
miniaturized broadband dielectric spectroscopy. In particular,
first, a broadband sensor interface IC as part of a miniaturized
measurement platform for MHz-to-GHz dielectric spectroscopy has
been developed. The IC measures frequency-dependent S21 magnitude
and phase of a microfluidic dielectric sensor fabricated in a thick
gold-on-glass microfabrication process and loaded with a
material-under-test (MUT). The sensor interfaced with the IC is
fully capable of differentiating among deionized (DI) water,
phosphate buffered saline (PBS), ethanol and methanol in tests
conducted at four different excitation frequencies of 50 MHz, 500
MHz, 1 GHz and 3 GHz. Further, dielectric readings of ethanol from
the sensor interfaced with the IC at five excitation frequencies in
the range of 50 MHz to 2 GHz are in excellent agreement (error <
1%) with those from using a vector network analyzer (VNA) as the
sensor readout.Next, a self-sustained, miniaturized,
microfluidic-CMOS platform for palmtop dielectric spectroscopy has
been developed. The platform incorporates a parallel-plate
capacitive sensor with a three-dimensional gap, floating electrode,
and microfluidic channel for sample delivery, as well as a fully
integrated transceiver for broadband dielectric spectroscopy. The
IC applies a single-tone sinusoidal RF excitation signal in a
frequency range of ~ 9MHz to 2.433GHz to the MUT-loaded sensor, and
measures the sensor transmission characteristics in the voltage
domain via an amplitude/phase measurement utilizing broadband
frequency response analysis (bFRA) to extract the MUT complex
permittivity with microliter sample volumes. Complex dielectric
readings of PBS from the platform at six excitation frequencies in
the range of 50 MHz to 2.4 GHz are in excellent agreement (RMS
error <1.5% for 0.5 to 2.4 GHz) with those from a reference
measurement by an Agilent 85070E dielectric probe kit interfaced
with a VNA.Finally, an autonomous self-sustained palmtop platform,
incorporating the microfluidic-CMOS platform, ADC, power supply
unit, Wi-Fi module, and a Raspberry Pi computing module has been
developed. The palmtop platform is capable of accurately measuring
the real and imaginary parts of MUT complex permittivity from ~
9MHz to 2.433GHz in less than 5s, enabling rapid, high-throughput,
and low-cost measurements with a self-sustained, portable platform
that can pave the way for translating dielectric spectroscopy from
the lab bench to the field or the bedside.
Advisors/Committee Members: Mohseni, Pedram (Advisor).
Subjects/Keywords: Engineering; Integrated Circuit, Broadband Dielectric Spectroscopy,
Sensor, Microfluidic, CMOS, Miniaturized, Transceiver
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bakhshiani, M. (2015). A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM
FORBROADBAND DIELECTRIC SPECTROSCOPY. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857
Chicago Manual of Style (16th Edition):
Bakhshiani, Mehran. “A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM
FORBROADBAND DIELECTRIC SPECTROSCOPY.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857.
MLA Handbook (7th Edition):
Bakhshiani, Mehran. “A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM
FORBROADBAND DIELECTRIC SPECTROSCOPY.” 2015. Web. 02 Mar 2021.
Vancouver:
Bakhshiani M. A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM
FORBROADBAND DIELECTRIC SPECTROSCOPY. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857.
Council of Science Editors:
Bakhshiani M. A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM
FORBROADBAND DIELECTRIC SPECTROSCOPY. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857
9.
Dermawan, Josephine Kam Tai.
From NF-κB to FACT: Mechanisms and Translational
Applications of EGFR-mediated NF-κB Regulation.
Degree: PhD, Molecular Medicine, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263
► The epidermal growth factor receptor (EGFR) drives downstream signaling pathways that promote cancer progression. EGFR is often constitutively active in tumors, e.g., non-small cell lung…
(more)
▼ The epidermal growth factor receptor (EGFR) drives
downstream signaling pathways that promote cancer progression. EGFR
is often constitutively active in tumors, e.g., non-small cell lung
cancer (NSCLC) and glioblastoma (GBM), either by overexpression or
mutations. Nuclear factor-κB (NF-κB) is a master transcription
factor that controls inflammation and innate immunity. NF-κB, often
constitutively activated in cancer, drives tumor development by
activating antiapoptotic and prosurvival genes, and has been
implicated in anticancer drug resistance. We and others have shown
that EGFR activates NF-κB signaling in both noncancerous and cancer
cells. In an attempt to overcome drug resistance to EGFR tyrosine
kinase inhibitors (TKI): erlotinib and lapatinib in NSCLC and GBM
respectively, we combined EGFR-TKI with a novel class of NF-κB
inhibitors, including quinacrine and curaxins, which inhibit
NF-κB-driven transcription by targeting the facilitates chromatin
transcription (FACT) complex. Unexpectedly, we discovered
preferential targeting of GBM stem cells (GSCs), another major
player in cancer therapeutic resistance, by curaxins, uncovering a
potential role of FACT in the maintenance of stem cell phenotypes.
Beyond applications in anticancer therapeutics, we are interested
in the basic biological question of how EGFR, compared to canonical
NF-κB activators such as interleukin 1 (IL-1), regulates NF-κB
distinctively. Specifically, we utilize genomic approaches
including RNA-sequencing (RNA-sequencing) and chromatin
immunoprecipitation (ChIP)-sequencing to investigate the
signal-specific, genome-wide regulation of NF-κB-driven
transcription by EGFR versus IL-1. One possible mechanism that
underlies specificity in transcription factor regulation is
differential phosphorylation. We speculate that phosphorylation of
the serine 276 residue on the NF-κB subunit p65 (RELA) plays a role
in EGFR-mediated NF-κB regulation. Using the gene editing approach
CRISPR, we have introduced the genetic mutation S276A in the
<i>RELA</i> gene. In the next phase, we plan to
interrogate the impact of this mutation in EGFR-mediated NF-κB
regulation. In addition, we will interrogate whether STAT3, a major
oncogene also activated by EGFR, serves as a transcriptional
coregulator in the context of NF-κB-driven transcription. Taken
together, these
studies elucidate how EGFR regulates NF-κB on a
genomic level, which remains poorly understood, and have major
implications in anticancer therapy and drug resistance, especially
in cancers driven by EGFR and/or NF-κB.
Advisors/Committee Members: Stark, George (Advisor), Jackson, Mark (Committee Chair).
Subjects/Keywords: Cellular Biology; Molecular Biology; Oncology; Genetics; ChIP-seq; CRISPR; epidermal growth factor receptor, EGFR; curaxins; facilitates chromatin transcription, FACT; glioblastoma; GBM stem cell; nuclear factor kappa B, NF-kappaB; non-small cell lung cancer; quinacrine; RNA-seq; transcriptional regulation
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dermawan, J. K. T. (2015). From NF-κB to FACT: Mechanisms and Translational
Applications of EGFR-mediated NF-κB Regulation. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263
Chicago Manual of Style (16th Edition):
Dermawan, Josephine Kam Tai. “From NF-κB to FACT: Mechanisms and Translational
Applications of EGFR-mediated NF-κB Regulation.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263.
MLA Handbook (7th Edition):
Dermawan, Josephine Kam Tai. “From NF-κB to FACT: Mechanisms and Translational
Applications of EGFR-mediated NF-κB Regulation.” 2015. Web. 02 Mar 2021.
Vancouver:
Dermawan JKT. From NF-κB to FACT: Mechanisms and Translational
Applications of EGFR-mediated NF-κB Regulation. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263.
Council of Science Editors:
Dermawan JKT. From NF-κB to FACT: Mechanisms and Translational
Applications of EGFR-mediated NF-κB Regulation. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263
10.
Zimmerman, Grant Robert.
T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT
AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS.
Degree: MSs, Pathology, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859
► Recent characterization of the bone marrow microenvironment has pointed to comprehensive dysregulation of hematopoietic-stromal interactions in the context of leukemia. We used common oncogenic mutations…
(more)
▼ Recent characterization of the bone marrow
microenvironment has pointed to comprehensive dysregulation of
hematopoietic-stromal interactions in the context of leukemia. We
used common oncogenic mutations in Notch to probe these
dysregulated interactions. We found an upregulation in cellular
homing receptor CXCR4 in Notch-driven leukemic cells. Inhibition of
Notch signaling using a gamma-secretase inhibitor in the stromal
environment led to lessening of leukemic burden, relief of stem
cell suppression, and normalized expression of CXCR4 by
non-leukemic hematopoietic progenitor cells. The stromal
environment was further characterized. Leukemic dysregulation was
seen to increase stromal expression of adhesion molecules while
decreasing osteoblastic differentiation. Final experiments sought
to tie these observations together using imaging to characterize
differences in cellular homing based on leukemic subpopulations
expressing different levels of CXCR4. Leukemic cells expressing
high levels of CXCR4 were seen to migrate preferentially to
vascular structures, suggesting a propensity to more proliferative
bone marrow microenvironments.
Advisors/Committee Members: Zhou, Lan (Advisor), Ramirez-Bergeron, Diana (Committee Chair).
Subjects/Keywords: Pathology; Medicine; Molecular Biology; Bone Marrow; Stromal Cells; Acute Lymphoblastic Leukemia; T-ALL; CXCR4; Notch; Leukemic Stem Cell
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zimmerman, G. R. (2015). T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT
AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859
Chicago Manual of Style (16th Edition):
Zimmerman, Grant Robert. “T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT
AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859.
MLA Handbook (7th Edition):
Zimmerman, Grant Robert. “T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT
AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS.” 2015. Web. 02 Mar 2021.
Vancouver:
Zimmerman GR. T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT
AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859.
Council of Science Editors:
Zimmerman GR. T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT
AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859
11.
HUANG, LING-YI.
Electronic Band Structure, Phonons and Exciton Binding
Energies of Halide Perovskites CsSnX3 with
X=Cl, Br, I.
Degree: PhD, Physics, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745
► Halide perovskites (ABX3) have attracted a large amount of attention since 2009 due to their important applications in solar cells. Though high power conversion efficiencies…
(more)
▼ Halide perovskites (ABX
3) have
attracted a large amount of attention since 2009 due to their
important applications in solar cells. Though high power conversion
efficiencies have been achieved, the underlying reasons for the
success are not fully understood. Moreover, some important issues
have not yet been resolved, mainly stability issues resulting from
phase transitions in halide perovskites. In this thesis, we used
the Full-Potential Linear Muffin-Tin Orbital method with
Quasiparticle Self-consistent <i>GW</i>
(QS<i>GW</i>) to study the electronic band structures
and related properties in one family of halide perovskites:
CsSnX
3 with X=I, Br, and Cl. We also used
density functional perturbation theory to perform phonon
calculations for these materials. Our first-principles calculations
are compared with experimental data. The main purpose of this study
is to understand the fundamental physical properties in these
materials and the underlying reasons for the success of these
materials in solar cells, and eventually to elucidate information
about phase transitions in these materials with the goal of
resolving the stability issues.Our QS<i>GW</i> band
gaps are in good agreement with experimental gaps. An extremely
interesting finding is that the halide perovskites have an
“inverted” band structure; i.e. in contrast to most conventional
semiconductors, their valence band has a strong
Sn-<i>s</i> like character (antibondingly mixed with
X-<i>p</i>) while their conduction band has
Sn-<i>p</i> character. The unusual characteristic
explains (i) the strong luminescence, (ii) the relatively weak band
gap dependence on anions, (iii) why the valence band maximum occurs
at the <b>R</b>-point, and (iv) the anomalous
dependence of the band gap on lattice constants. We also find that
the small effective hole mass results in high hole mobility. The
free-exciton binding energy was estimated to be of the order of 0.1
meV for CsSnI
3. Strong LO-TO splittings and
large static dielectric constants are found. LO phonons contribute
to infrared absorption spectra of α-CsSnBr
3
and α-CsSnCl
3 and Raman spectra of
γ-CsSnI
3 and
<i>M</i>-CsSnCl
3. Strong
LO-plasmon couplings are expected in these materials because the
plasmon frequencies are comparable to the LO phonon frequencies. We
find soft phonons, which are phonons with imaginary phonon
frequencies, in cubic and tetragonal phases, but not in
orthorhombic and monoclinic phases. The phase transitions from the
α phase to the β phase and then to the γ phase can be summarized,
in terms of space groups and soft phonons, as
follows<i>O</i>
h1
―
(<i>M</i>
2+)
➝
<i>D</i>
4h5
―
(<i>Z</i>
5-)
➝
<i>D</i>
2h16,
where the
<i>M</i>
2+
and
<i>Z</i>
5-
are the soft phonons in the cubic and tetragonal phases,
respectively. The displacement pattern of the
<i>M</i>
2+…
Advisors/Committee Members: Lambrecht, Walter (Advisor).
Subjects/Keywords: Physics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
HUANG, L. (2015). Electronic Band Structure, Phonons and Exciton Binding
Energies of Halide Perovskites CsSnX3 with
X=Cl, Br, I. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745
Chicago Manual of Style (16th Edition):
HUANG, LING-YI. “Electronic Band Structure, Phonons and Exciton Binding
Energies of Halide Perovskites CsSnX3 with
X=Cl, Br, I.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745.
MLA Handbook (7th Edition):
HUANG, LING-YI. “Electronic Band Structure, Phonons and Exciton Binding
Energies of Halide Perovskites CsSnX3 with
X=Cl, Br, I.” 2015. Web. 02 Mar 2021.
Vancouver:
HUANG L. Electronic Band Structure, Phonons and Exciton Binding
Energies of Halide Perovskites CsSnX3 with
X=Cl, Br, I. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745.
Council of Science Editors:
HUANG L. Electronic Band Structure, Phonons and Exciton Binding
Energies of Halide Perovskites CsSnX3 with
X=Cl, Br, I. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745
12.
Alouani, David James.
THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME
DEPENDENT PROTEIN EXPRESSION ANALYSIS.
Degree: MSs, Systems Biology and Bioinformatics, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267
► The main goal of the present effort is to develop a comprehensive computational and statistical framework for analyzing large scale proteomics data and understand the…
(more)
▼ The main goal of the present effort is to develop a
comprehensive computational and statistical framework for analyzing
large scale proteomics data and understand the aging process of
Caenorhabditis elegans (C.elegans) nematodes based on the age
dependent pattern of the protein expression. Modern numerical
methods were used for the analysis, including outlier detection,
imputation, entropy and feature selection. Protein expression in C.
elegans was found to be highly age dependent. Increased expression
in younger nematodes was associated with the activation of
metabolic pathways. House-keeping processes, such as proteolysis,
protein biogenesis and assembly were found to be important at older
age. Network entropy was also found to be age dependent for a
significant fraction of proteins. Increased protein expression was
associated with reduced entropy. Feature selection analysis further
showed that proteins linked to metabolic processes are most
predictive of the age of C. elegans nematodes, based on their level
of expression.
Advisors/Committee Members: Miyagi, Masaru (Advisor).
Subjects/Keywords: Bioinformatics; Biology; Biostatistics; Computer Science; Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Alouani, D. J. (2015). THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME
DEPENDENT PROTEIN EXPRESSION ANALYSIS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267
Chicago Manual of Style (16th Edition):
Alouani, David James. “THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME
DEPENDENT PROTEIN EXPRESSION ANALYSIS.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267.
MLA Handbook (7th Edition):
Alouani, David James. “THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME
DEPENDENT PROTEIN EXPRESSION ANALYSIS.” 2015. Web. 02 Mar 2021.
Vancouver:
Alouani DJ. THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME
DEPENDENT PROTEIN EXPRESSION ANALYSIS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267.
Council of Science Editors:
Alouani DJ. THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME
DEPENDENT PROTEIN EXPRESSION ANALYSIS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267
13.
Trinh, Tat To.
REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION
ELEMENTS AND miRNAs.
Degree: PhD, Biochemistry, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986
► Messenger (mRNA) deadenylation is thought to be rate limiting for and to trigger of mRNA decay, either 5’ to 3’ or 3’ to 5’. In…
(more)
▼ Messenger (mRNA) deadenylation is thought to be rate
limiting for and to trigger of mRNA decay, either 5’ to 3’ or 3’ to
5’. In a survey of polyA tail length of specific mRNAs in
Drosophila S2 cells, we found several, including reaper and arc-1
mRNAs, that exhibited very short or non-existent polyA tails.
Knockdown of deadenylase components revealed that reaper mRNAs were
synthesized with normal polyA tails, a result in which indicated
that the tail-less mRNAs had been rapidly deadenylated. Maintenance
of capped but deadenylated state in the reaper mRNA requires three
cis-acting elements in the 3' UTR. Interestingly, arc- 1
transcripts are found to be insensitive to deadenylases depletion,
strongly suggesting that they are not ever polyadenylated. More
surprisingly, these deadenylated mRNAs were found to be fully
associated with actively translating ribosomes. Disaggregation of
polysomes under hypertonic conditions followed by recovery in
isotonic conditions shows that the deadenylated mRNAs can be
efficiently translated. To rule out the possibility of reinitiation
of translation required the full polyA tail, we treated S2 cells
with harringtonine and showed accumulation of deadenylated species
on 80S fraction. For these and possibly other mRNAs, a polyA tail
is not required for translation.The mechanism whereby microRNAs
(miRNAs) repress protein output from targeted mRNAs remains in
question. Substantive evidence indicates that miRNAs function
primarily, if not exclusively, by destabilizing their mRNA targets.
Whether destabilization is the consequence of inhibition of
initiation of translation is still debated. Other evidence has
suggested that miRNAs inhibit translation at some step after
initiation but mechanistic insight into how this could occur has
been difficult to obtain. The notion that miRNAs impact translation
post initiation derives largely from many observations that miRNA
targets and miRNAs themselves appear to be associated with actively
translating ribosomes. The vast majority of
studies that had
examined mechanism of miRNA-mediated repression have been carried
out using transient transfection of both targets and miRNAs; most
often with engineered 3' UTRs. Here, we made stable cell lines
expressing the well-characterized miRNA-targeted 3' UTRs of
Drosophila reaper and hid. Lines expressing two versions of each
UTR, one with wild type miRNA recognition sites, and one where the
recognition sites were mutated, were studied. All detectable mRNAs
from all four lines were associated with actively translating
ribosomes as assessed by harringtonine treatment and northern
blotting. Half-life measurements showed that mRNAs containing wild
type miRNA recognition sites were dramatically destabilized when
compared to those with mutant recognition sites. When transcription
was arrested, we observed a rapid accumulation of mRNA fragments.
These fragments resulted from progressive truncation from the 5'
end of the mRNA and were ribosome associated. These data indicate
that mRNA-mediated mRNA destabilization and…
Advisors/Committee Members: Nilsen, Timothy (Advisor), Coller, Jeffery (Committee Chair).
Subjects/Keywords: Biochemistry; deadenylation, miRNA, mRNA destabilization,
cotranslational mRNA decay
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Trinh, T. T. (2015). REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION
ELEMENTS AND miRNAs. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986
Chicago Manual of Style (16th Edition):
Trinh, Tat To. “REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION
ELEMENTS AND miRNAs.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986.
MLA Handbook (7th Edition):
Trinh, Tat To. “REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION
ELEMENTS AND miRNAs.” 2015. Web. 02 Mar 2021.
Vancouver:
Trinh TT. REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION
ELEMENTS AND miRNAs. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986.
Council of Science Editors:
Trinh TT. REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION
ELEMENTS AND miRNAs. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986
14.
Bezik, Cody.
Poly(High Internal Phase Emulsion) Foams and Fibers:
Structure-Property Relationships.
Degree: MSs (Engineering), Chemical Engineering, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970
► Poly(high internal phase emulsions) are highly porous open-cell foams formed by emulsion templating. These foams have many applications, but the fundamental relationship of emulsion properties…
(more)
▼ Poly(high internal phase emulsions) are highly porous
open-cell foams formed by emulsion templating. These foams have
many applications, but the fundamental relationship of emulsion
properties to the final foam properties is not well understood, nor
is the relationship between the morphology of the foam to its own
properties. In this thesis, these relationships are further
elucidated. It is shown that changing electrolyte concentration
leads to changes in foam modulus, which are shown to be correlated
with the internal surface area. Furthermore, this relationship is
shown to peak at an intermediate value and is dependent on emulsion
curing conditions.The feasibility of creating novel poly(HIPE)
fibers is also explored and demonstrated. It is shown that the
surface porosity of the fibers can be tuned by additions to the
curing bath, and that interfacial polymerization in the curing bath
can result in a shell being grown on the fiber
surface.
Advisors/Committee Members: Feke, Donald (Advisor), Manas-Zloczower, Ica (Advisor).
Subjects/Keywords: Chemical Engineering; Polymers; High internal phase emulsion; polymeric monoliths; emulsion stability; porous fibers
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bezik, C. (2015). Poly(High Internal Phase Emulsion) Foams and Fibers:
Structure-Property Relationships. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970
Chicago Manual of Style (16th Edition):
Bezik, Cody. “Poly(High Internal Phase Emulsion) Foams and Fibers:
Structure-Property Relationships.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970.
MLA Handbook (7th Edition):
Bezik, Cody. “Poly(High Internal Phase Emulsion) Foams and Fibers:
Structure-Property Relationships.” 2015. Web. 02 Mar 2021.
Vancouver:
Bezik C. Poly(High Internal Phase Emulsion) Foams and Fibers:
Structure-Property Relationships. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970.
Council of Science Editors:
Bezik C. Poly(High Internal Phase Emulsion) Foams and Fibers:
Structure-Property Relationships. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970
15.
Salwiesz, Michael C.
The Impact of Parent Involvement on the Education of
Children: Unlocking the Role of Parent Involvement in Promoting
Academic Achievement Among Racially Diverse Kindergarteners.
Degree: PhD, Social Welfare, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483
► The literature overwhelmingly supports the benefits of education. Nevertheless, the reality of the modern education system is that all students do not have an equal…
(more)
▼ The literature overwhelmingly supports the benefits of
education. Nevertheless, the reality of the modern education system
is that all students do not have an equal chance of attaining the
education that has so much transformative power. A significant
achievement gap between minority and low-income students and their
European-American and more affluent peers continues to produce
inequalities in the educational and life course outcomes for
minority and low-income students throughout the United States. In
an effort to address these inequities, federal initiatives have
emphasized the role of parents in the education of their children
and have included parents in nearly every policy initiative aimed
at improving academic achievement for the past 50 years. Even
though parent involvement has received tremendous support, there is
limited evidence on the specific dimensions of parent involvement
that impact academic achievement, the impact of parent involvement
on diverse groups, and the impact of parent involvement on the
achievement gap.This study utilized the ecological systems theory
and Epstein’s Theory of Overlapping Spheres to examine the
relationship between parent involvement and academic achievement on
racially diverse kindergarteners (N=13,655). This study utilized
hierarchical linear modeling and data from the Early Childhood
Longitudinal Study, Kindergarten Class (ECLS-K). The dataset was
selected because it collects information on parent involvement and
academic achievement variables, while the overwhelming majority of
datasets focus exclusively on one set of variables. This study
found that parent involvement has a tremendous positive impact on
both reading and math achievement, but fell short of supporting the
notion that all forms of parent involvement are beneficial.
Furthermore, this study found significant differences in the
relationship between parent involvement and academic achievement by
race. After more than a half-century recognizing the importance of
parent involvement, we are still at the beginning stages of truly
understanding how to unlock the full potential of parent
involvement on academic achievement for all learners. This
dissertation is a call to all educators, policymakers, and
researchers to unlock the full potential of parent involvement to
raise academic achievement for all students, with a special
emphasis on mitigating the inequities throughout the education
system.
Advisors/Committee Members: Joseph, Mark (Committee Chair).
Subjects/Keywords: Education; Social Work; Parent Involvement; Kindergarten; Multilevel Modeling; Academic Achievement
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Salwiesz, M. C. (2015). The Impact of Parent Involvement on the Education of
Children: Unlocking the Role of Parent Involvement in Promoting
Academic Achievement Among Racially Diverse Kindergarteners. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483
Chicago Manual of Style (16th Edition):
Salwiesz, Michael C. “The Impact of Parent Involvement on the Education of
Children: Unlocking the Role of Parent Involvement in Promoting
Academic Achievement Among Racially Diverse Kindergarteners.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483.
MLA Handbook (7th Edition):
Salwiesz, Michael C. “The Impact of Parent Involvement on the Education of
Children: Unlocking the Role of Parent Involvement in Promoting
Academic Achievement Among Racially Diverse Kindergarteners.” 2015. Web. 02 Mar 2021.
Vancouver:
Salwiesz MC. The Impact of Parent Involvement on the Education of
Children: Unlocking the Role of Parent Involvement in Promoting
Academic Achievement Among Racially Diverse Kindergarteners. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483.
Council of Science Editors:
Salwiesz MC. The Impact of Parent Involvement on the Education of
Children: Unlocking the Role of Parent Involvement in Promoting
Academic Achievement Among Racially Diverse Kindergarteners. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483
16.
Aranjuez, George Gil Fajardo.
Cellular Mechanisms that Promote the Collective Migratory
Behavior of Drosophila Border Cells.
Degree: PhD, Genetics, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488
► Collective migration is a type of cell movement wherein groups of cells move together as a coherent unit. Collective migration is involved in multiple aspects…
(more)
▼ Collective migration is a type of cell movement
wherein groups of cells move together as a coherent unit.
Collective migration is involved in multiple aspects of development
across many organisms. Different forms of collective migration are
observed in many biological processes such as gastrulation,
tubulogenesis, neural crest migration and wound healing. Cancer
cells can also spread via collective migration in the form of
cellular streams. The hallmark of collective migration is the
action of cellular mechanisms that control and shape the motility
of the individual cells in the group. Despite the broad impact on
normal development and disease, the molecular mechanisms that
facilitate collective migration are still not well understood. I
used border cell migration in the Drosophila ovary to study the
mechanisms that promote collective movement. Border cell migration
occurs in the egg chamber, which is composed of an oocyte and
supportive nurse cells enveloped by a monolayer of follicle cell
epithelium. During oogenesis, border cells originate from the
follicle epithelium, assemble into a cluster of 4-6 cells and
migrate in a ligand-guided fashion in between the nurse cells to
reach the oocyte. Through a genetic screen, I identified new genes
that are important for border cell migration. One of these genes,
the serine/threonine kinase drop out (dop), promotes the
stereotypic migratory behavior of the border cell cluster. Dop
mutant border cell clusters extend ectopic protrusions and fail to
complete migration. In vivo, collectively migrating cells maintain
group cohesion while negotiating various physical hindrances such
as the extracellular matrix or other cells. Border cell clusters
squeeze in between larger cell types while maintaining a compact
shape. I discovered waves of actomyosin contractility at the
periphery of the cluster. Loss of peripheral actomyosin
contractility leads to the deformation of the cluster and failure
to complete migration. It is important to identify these
supracellular mechanisms to understand collective
migration.
Advisors/Committee Members: McDonald, Jocelyn (Advisor), Salz, Helen (Committee Chair).
Subjects/Keywords: Cellular Biology; Developmental Biology; collective migration; Drosophila; border cells; myosin; oogenesis; drop out
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Aranjuez, G. G. F. (2015). Cellular Mechanisms that Promote the Collective Migratory
Behavior of Drosophila Border Cells. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488
Chicago Manual of Style (16th Edition):
Aranjuez, George Gil Fajardo. “Cellular Mechanisms that Promote the Collective Migratory
Behavior of Drosophila Border Cells.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488.
MLA Handbook (7th Edition):
Aranjuez, George Gil Fajardo. “Cellular Mechanisms that Promote the Collective Migratory
Behavior of Drosophila Border Cells.” 2015. Web. 02 Mar 2021.
Vancouver:
Aranjuez GGF. Cellular Mechanisms that Promote the Collective Migratory
Behavior of Drosophila Border Cells. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488.
Council of Science Editors:
Aranjuez GGF. Cellular Mechanisms that Promote the Collective Migratory
Behavior of Drosophila Border Cells. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488
17.
Sun, Mengmeng.
COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR
VISUALIZING SNOMED CT FRAGMENTS.
Degree: MSs, EECS - Computer and Information Sciences, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297
► Many clinical ontology search interfaces have been developed to provide access to ontological information. However, existing search interfaces are insufficient for ontology quality assurance work.…
(more)
▼ Many clinical ontology search interfaces have been
developed to provide access to ontological information. However,
existing search interfaces are insufficient for ontology quality
assurance work. My master thesis focuses on developing a
Conjunctive Ontology Browser and Explorer (COBE) for searching and
exploring SNOMED CT concepts and visualizing SNOMED CT non-lattice
fragments.COBE combines navigational exploration (NE) with direct
lookup (DL) as two complementary search modes. The NE mode provides
a conjunctive mechanism for users to quickly find the most frequent
concepts related to SNOMED CT non-lattice fragments. Users can
interactively and incrementally narrow down (hence conjunctive) the
search space by adding precomputed word stems provided by COBE, one
at a time. Such word stems serve as attribute constraints, or
“attributes” in Formal Concept Analysis, which al- lows users to
navigate to specific SNOMED CT concept clusters. The DL mode
represents the common search mechanism by using a collection of key
words given by users, as well as concept identifiers. The other
defined feature of COBE is the visualization of fragments, which
facilitating the further investigation and curation of such
structures.With respect to the NE mode, COBE leverages 28,371 of
total 302,902 concepts occurring in the fragments of interest to
construct the stem cloud. With merely 9.37% of the total SNOMED CT
concepts, the exploratory navigation mode reaches 98.97% coverage
of the entire concept collection. With respect to the DL mode,
evaluation against manually created reference standard shows that
COBE attains an example-based precision of 0.958, recall of 0.917,
and F1-measure of 0.875.
Advisors/Committee Members: Zhang, Guo-qiang (Advisor).
Subjects/Keywords: Computer Science; SNOMED CT; web design; search interface
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sun, M. (2015). COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR
VISUALIZING SNOMED CT FRAGMENTS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297
Chicago Manual of Style (16th Edition):
Sun, Mengmeng. “COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR
VISUALIZING SNOMED CT FRAGMENTS.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297.
MLA Handbook (7th Edition):
Sun, Mengmeng. “COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR
VISUALIZING SNOMED CT FRAGMENTS.” 2015. Web. 02 Mar 2021.
Vancouver:
Sun M. COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR
VISUALIZING SNOMED CT FRAGMENTS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297.
Council of Science Editors:
Sun M. COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR
VISUALIZING SNOMED CT FRAGMENTS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297
18.
Schinaman, Joseph Moeller.
INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN
DROSOPHILA.
Degree: PhD, Biology, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103
► Courtship is a behavior common to many species in which members of one gender advertise to the other their species identity and overall fitness. In…
(more)
▼ Courtship is a behavior common to many species in
which members of one gender advertise to the other their species
identity and overall fitness. In many species, the male courts the
female, and the male’s courtship display provides a complex array
of auditory, visual and olfactory information to the courted
female, which must be decoded to generate the decision to accept or
reject the potential mate. However, despite the centrality of
courtship behavior to the evolution and maintenance of species,
relatively little is known about the genetic and neural circuitry
underlying female mate choice. To investigate this process in
detail, we have analyzed the courtship acceptance behavior of
Drosophila melanogaster, a species in which females are presented
with multimodal sensory information during courtship. In this work,
we show that Drosophila females mutant for the Kruppel-like
transcription factor datilografo (dati) are incapable of accepting
males, despite eliciting normal courtship from them. To facilitate
further study of this gene’s role in patterning the brain for
acceptance behavior, we used a novel system to perform clonal
analyses of genes on the fourth chromosome, the genomic location of
dati. The analysis of Drosophila females bearing labelled patches
of dati mutant tissue throughout the brain revealed three regions
where this transcription factor is required for normal acceptance
behavior: the antennal lobe of the anterior brain, and two regions
flanking the lateral2horn in the posterior brain. These regions
encompass areas of olfactory signal processing and sensory
integration, respectively. In addition to the experiments above, we
carried out an RNA interference screen to determine the
neurotransmitter profile of dati neurons required for female
acceptance behavior. This screen revealed that dati is required in
cholinergic neurons. Finally, to determine precisely the position
and number of individual neurons that mediate female acceptance
behavior in the regions identified, we determined which dati
neurons were cholinergic. Ultimately we found around 60 neuron
spread across three regions. In whole, this work highlights
indispensable and tractably-sized areas of the overall courtship
acceptance circuit, and supports a stimuli-summation mechanism of
courtship acceptance.
Advisors/Committee Members: Mizutani, Claudia (Advisor), Sousa-Nves, Rui (Advisor).
Subjects/Keywords: Biology; Neurobiology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Schinaman, J. M. (2015). INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN
DROSOPHILA. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103
Chicago Manual of Style (16th Edition):
Schinaman, Joseph Moeller. “INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN
DROSOPHILA.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103.
MLA Handbook (7th Edition):
Schinaman, Joseph Moeller. “INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN
DROSOPHILA.” 2015. Web. 02 Mar 2021.
Vancouver:
Schinaman JM. INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN
DROSOPHILA. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103.
Council of Science Editors:
Schinaman JM. INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN
DROSOPHILA. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103
19.
Chen, Xi.
SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING
EMBRYOGENESIS IN ZEBRAFISH.
Degree: MSs, Biology, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069
► Mechanotransduction is involved in many physiological functions such as touch, hearing, and pain. A variety of tissues and organs have been shown to be mechanosensitive,…
(more)
▼ Mechanotransduction is involved in many physiological
functions such as touch, hearing, and pain. A variety of tissues
and organs have been shown to be mechanosensitive, from skin,
muscle and bone – to the delicate structures of the inner ear. The
mechanotransduction process is initiated by opening
mechanosensitive channels located on mechanosensitive cells. The
mechanotransduction process is initiated by opening
mechanosensitive channels on the cells of these special tissues. I
chose one family of mechanosensitive ion channel proteins -
particlulary important in the functioning of the ear and possibly
other organs - for preliminary identification. In this study, my
goal was to determine the spatiotemporal expression of four
paralogous genes in mechanosensitive tissues of the zebrafish by
whole-mount in situ hybridization.
Advisors/Committee Members: McDermott , Brian (Advisor).
Subjects/Keywords: Biology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chen, X. (2015). SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING
EMBRYOGENESIS IN ZEBRAFISH. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069
Chicago Manual of Style (16th Edition):
Chen, Xi. “SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING
EMBRYOGENESIS IN ZEBRAFISH.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069.
MLA Handbook (7th Edition):
Chen, Xi. “SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING
EMBRYOGENESIS IN ZEBRAFISH.” 2015. Web. 02 Mar 2021.
Vancouver:
Chen X. SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING
EMBRYOGENESIS IN ZEBRAFISH. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069.
Council of Science Editors:
Chen X. SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING
EMBRYOGENESIS IN ZEBRAFISH. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069
20.
Fecteau, Ryan E.
Genome-wide Approaches for Discovery of Novel Genetic and
Epigenetic Events in Gastrointestinal Cancer.
Degree: PhD, Pathology, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464
► Cancer is a disease caused by the sequential acquisition of genetic and epigenetic changes that transform a normal cell into an ungovernable malignancy. Advances in…
(more)
▼ Cancer is a disease caused by the sequential
acquisition of genetic and epigenetic changes that transform a
normal cell into an ungovernable malignancy. Advances in
technologies to interrogate these changes on a genome-wide scale
have reshaped our understanding of this disease and rapidly
expanded the field of cancer genomics. The objective of the
projects described herein was to adapt high-throughput methods to
discover and characterize novel genetic and epigenetic events in
gastrointestinal cancers with the intention of translational
application. Three primary
studies comprise the body of this
thesis. In the first, we identify recurrent mutations in the
oncogene GNAS found by sequencing of the colorectal cancer genome.
Targeted pyrosequencing of GNAS in a colon cancer tumor cohort
established a mutation frequency in colorectal cancer of around 2%.
By comparing GNAS mutation status with clinical and pathologic
data, we found that GNAS mutations associate with a distinct class
of colon cancers that are characterized by concomitant KRAS or BRAF
mutations, by location in the proximal colon, and by a unique
association with a villous morphology. The second study applied a
targeted next generation sequencing approach, whole exome
sequencing, to identify a germ-line susceptibility variant in a
familial syndrome of Barrett’s esophagus and esophageal
adenocarcinoma. Sequencing revealed a private variant in the
uncharacterized gene VSIG10L that segregated with disease in a
large familial Barrett’s esophagus family and functional
studies
suggested the discovered variant disrupted maturation of the normal
esophageal epithelium. Lastly, we describe using reduced
representation bisulfite sequencing to examine the colon cancer
methylome for candidate methylated biomarker loci. Preliminary data
from this work has identified 3 candidate methylated DNA biomarkers
for potential use in detection of colorectal cancer in patient
plasma. Cumulatively, these
studies have identified a rare mutation
in colon cancer associated with a unique molecular phenotype, a
private germ-line variant predisposing to familial Barrett’s
esophagus and adenocarcinoma, and candidate methylated biomarkers
for detection and monitoring of colon cancer, all of which are of
potential clinical importance.
Advisors/Committee Members: Markowitz, Sanford (Advisor).
Subjects/Keywords: Pathology; Genetics; Oncology; Gastrointestinal cancer; translational; next generation sequencing; colon cancer; Barretts esophagus; esophageal adenocarcinoma
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fecteau, R. E. (2015). Genome-wide Approaches for Discovery of Novel Genetic and
Epigenetic Events in Gastrointestinal Cancer. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464
Chicago Manual of Style (16th Edition):
Fecteau, Ryan E. “Genome-wide Approaches for Discovery of Novel Genetic and
Epigenetic Events in Gastrointestinal Cancer.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464.
MLA Handbook (7th Edition):
Fecteau, Ryan E. “Genome-wide Approaches for Discovery of Novel Genetic and
Epigenetic Events in Gastrointestinal Cancer.” 2015. Web. 02 Mar 2021.
Vancouver:
Fecteau RE. Genome-wide Approaches for Discovery of Novel Genetic and
Epigenetic Events in Gastrointestinal Cancer. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464.
Council of Science Editors:
Fecteau RE. Genome-wide Approaches for Discovery of Novel Genetic and
Epigenetic Events in Gastrointestinal Cancer. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464
21.
Gregory, Jill Christine.
Transmission of Atherosclerosis and Thrombosis
Susceptibility with Gut Microbial Transplantation.
Degree: PhD, Molecular Medicine, 2015, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679
► The overall goal of my thesis research is to further the understanding of the link among dietary trimethylamine-containing nutrients, intestinal microbiome, and cardiovascular disease (CVD)…
(more)
▼ The overall goal of my thesis research is to further
the understanding of the link among dietary
trimethylamine-containing nutrients, intestinal microbiome, and
cardiovascular disease (CVD) by testing the hypothesis that disease
susceptibility is a transmissible trait via cecal microbial
transplant. The positive correlation discovered between plasma TMAO
and lesion in a panel of inbred mouse strains permitted the
identification of atherosclerosis prone (high TMAO-producing, large
lesion; C57BL/6J) and resistant mice (low TMAO-producing, small
lesion; NZW/LacJ) to be used as donor strains for cecal microbial
transplant into intestinal microbiota-suppressed recipient C57BL/6J
Apoe-/- female mice. Recipients of C57BL/6J microbes on the choline
diet initially had statistically significantly higher plasma TMA
and TMAO as compared to choline diet NZW/LacJ recipients, and at
the study endpoint, choline diet-dependent enhancement of
atherosclerotic lesion area was observed in the recipients of
C57BL/6J microbes but not in recipients of NZW/LacJ microbes.
Examination of microbial communities from 16S rRNA bacterial gene
sequencing analysis showed distinct donor communities faithfully
transferred to the respective recipient mouse groups. Several donor
strain-characteristic taxa were identified in recipient groups
whose proportional abundances correlated with plasma TMAO and/or
lesion area. The second set of
studies explores thrombosis
potential and platelet reactivity, the proximal events in heart
attack and stroke, for a relationship with the microbiome. Plasma
TMAO is associated with a 2-fold increased risk for thrombotic
events in a large cohort (n=4007). TMAO enhances agonist dependent
platelet responsiveness by increasing the release of intracellular
calcium stores. In mice, provision of TMAO or dietary choline
(solely in the setting of an intact microbial community) enhances
platelet aggregation <i>ex vivo</i> and shortens the
time to cessation of blood flow <i>in vivo</i>. Cecal
microbial transplant study showed that germ-free recipients of the
disease-prone donor microbes were transmitted bacterial
communities, choline diet-dependent enhanced TMA lyase activity,
elevated plasma TMAO, and prothrombotic phenotypes as compared to
recipients of disease-resistant donors. Collectively, the results
of these
studies suggest that the body and its microbial
inhabitants interact to promote health or disease. Targeting
microbial communities could be an adjunct treatment for the
management of cardiometabolic disease in the future.
Advisors/Committee Members: Hazen, Stanley (Advisor), Kirwan, John (Committee Chair).
Subjects/Keywords: Biochemistry; Biomedical Research; Biology; Bioinformatics; Ecology; Health; Microbiology; Molecular Biology; Nutrition; Atherosclerosis; Choline; Dyslipidemia; Gut Microbiota; Koch Postulate; Lipid; Nutrition; Phospholipid; Thrombosis; Trimethylamine N-Oxide; TMAO
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gregory, J. C. (2015). Transmission of Atherosclerosis and Thrombosis
Susceptibility with Gut Microbial Transplantation. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679
Chicago Manual of Style (16th Edition):
Gregory, Jill Christine. “Transmission of Atherosclerosis and Thrombosis
Susceptibility with Gut Microbial Transplantation.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679.
MLA Handbook (7th Edition):
Gregory, Jill Christine. “Transmission of Atherosclerosis and Thrombosis
Susceptibility with Gut Microbial Transplantation.” 2015. Web. 02 Mar 2021.
Vancouver:
Gregory JC. Transmission of Atherosclerosis and Thrombosis
Susceptibility with Gut Microbial Transplantation. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679.
Council of Science Editors:
Gregory JC. Transmission of Atherosclerosis and Thrombosis
Susceptibility with Gut Microbial Transplantation. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679
22.
Guan, Dongyin.
Post-transcriptional Regulation of PML protein by Distinct
Mechanisms.
Degree: PhD, Biochemistry, 2016, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253
► The promyelocytic leukemia (PML) protein is a tumor suppressor originally identified in acute promyelocytic leukemia and implicated in tumorigenesis in multiple forms of cancer. PML…
(more)
▼ The promyelocytic leukemia (PML) protein is a tumor
suppressor originally identified in acute promyelocytic leukemia
and implicated in tumorigenesis in multiple forms of cancer. PML
protein is frequently down-regulated in various cancers, but PML
mRNA levels are relatively similar between normal and cancerous
tissues (1). These observations indicate that PML protein levels
are tightly regulated, in part, through post-transcriptional
regulation. We previously demonstrated that the PML protein
undergoes ubiquitination (Ub)-mediated degradation facilitated by
an E3 ligase UHRF1 (2), and that SIRT1/SIRT5 promotes deacetylation
and SUMO1 conjugation of PML (3) in response to oxidative stress.
Here, we found that the small noncoding RNA miR-24 and miR-133
target 3’ UTR of PML1 mRNA, the major PML isoform in primary human
endothelial cells (ECs). In normal culture condition, miR-24 and
miR-133 down-regulate PML1 protein expression in primary human ECs.
However, miR-24 but not miR-133 up-regulates PML1 protein
expression under starvation condition. Moreover, miR-24 inhibits
ECs angiogenesis, while knocking down PML attenuates the inhibitory
effect of miR-24 to angiogenesis. We further confirm miR-24
inhibitory effect on angiogenesis ex-vivo. We found that miR-24
inhibits angiogenesis of PML wild-type but not PML-/- mouse aortic
ECs as demonstrated by aorta ring assays. These findings revealed a
new mechanism that miR-24 switches from an inhibitor to an
activator of PML1 mRNA translation under serum starvation
condition.
Advisors/Committee Members: Kao, Hung-Ying (Advisor), Samols, David (Committee Chair).
Subjects/Keywords: Biomedical Research; pml, miRNA, UHRF1, SIRT1, SIRT5
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Guan, D. (2016). Post-transcriptional Regulation of PML protein by Distinct
Mechanisms. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253
Chicago Manual of Style (16th Edition):
Guan, Dongyin. “Post-transcriptional Regulation of PML protein by Distinct
Mechanisms.” 2016. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253.
MLA Handbook (7th Edition):
Guan, Dongyin. “Post-transcriptional Regulation of PML protein by Distinct
Mechanisms.” 2016. Web. 02 Mar 2021.
Vancouver:
Guan D. Post-transcriptional Regulation of PML protein by Distinct
Mechanisms. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253.
Council of Science Editors:
Guan D. Post-transcriptional Regulation of PML protein by Distinct
Mechanisms. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253
23.
Han, Lu.
Light Management in Photovoltaic Devices and Nanostructure
Engineering in Nitride-based Optoelectronic Devices.
Degree: PhD, EECS - Electrical Engineering, 2017, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605
► Currently, there are several issues that limit the efficiency and performance of modern semiconductor optoelectronic devices. Photovoltaics are promising optoelectronic devices for generating electrical power…
(more)
▼ Currently, there are several issues that limit the
efficiency and performance of modern semiconductor optoelectronic
devices. Photovoltaics are promising optoelectronic devices for
generating electrical power directly from sunlight on a large
scale, with the potential to reduce the worldwide usage of
nonrenewable energy. One limiting factor to further enhance the
conversion efficiency for solar cells is the undesired interfacial
photon energy loss, which is attributed to the refractive index
difference at the interface between the semiconductor materials and
the surrounding medium. Light management by employing interfacial
light coupling elements is one important strategy to further
improve the efficiency of solar cells. In this dissertation, my
research work focuses on improving the light trapping in solar
cells by systematically designing microdome-based and
impedance-matching concaved microdome-based structures, with the
goal to achieve broadband omnidirectional antireflection.Light
emitters using wide band gap semiconductors play important roles in
industrial, residential and military applications. The performance
of light emitters significantly depends on the design and quality
of active medium in the devices. The second part of this
dissertation focuses on the nanostructure design and engineering
for quantum well active medium by utilizing the heterostructures of
III-nitride and II-IV-nitride with the goal to achieve high
efficiency light emitters. The novel type-II InGaN-ZnGeN2 QW
heterostructures for high-performance blue-/green-/red-LEDs are
able to address the charge separation issue in traditional
III-nitride LEDs emitting in green and longer wavelength range.
Further, the closely lattice-matched of GaN-ZnGeN2 coupled QW
structure is able to achieve intersubband transitions promising for
near-infrared quantum cascade laser applications.
Advisors/Committee Members: Zhao, Hongping (Committee Chair).
Subjects/Keywords: Electrical Engineering; Optics; Solid State Physics; Experiments; Physics; Light coupling; Interfacial coupling structures; Photovoltaics; Microdome structures; Concaved-dome structures; Nanostructure engineering; Optoelectric devices; LEDs; II-IV-nitride; III-nitride; Type-II QW; Near-IR quantum cascade laser
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Han, L. (2017). Light Management in Photovoltaic Devices and Nanostructure
Engineering in Nitride-based Optoelectronic Devices. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605
Chicago Manual of Style (16th Edition):
Han, Lu. “Light Management in Photovoltaic Devices and Nanostructure
Engineering in Nitride-based Optoelectronic Devices.” 2017. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605.
MLA Handbook (7th Edition):
Han, Lu. “Light Management in Photovoltaic Devices and Nanostructure
Engineering in Nitride-based Optoelectronic Devices.” 2017. Web. 02 Mar 2021.
Vancouver:
Han L. Light Management in Photovoltaic Devices and Nanostructure
Engineering in Nitride-based Optoelectronic Devices. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2017. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605.
Council of Science Editors:
Han L. Light Management in Photovoltaic Devices and Nanostructure
Engineering in Nitride-based Optoelectronic Devices. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605
24.
Romey, John Andrew, III.
Popular Song, Opera Parody, and the Construction of Parisian
Spectacle, 1648–1713.
Degree: PhD, Music History, 2018, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338
► This dissertation examines the interplay between popular and elite song traditions in early modern Paris. Individuals participating in these separate but interrelated traditions composed new…
(more)
▼ This dissertation examines the interplay between
popular and elite song traditions in early modern Paris.
Individuals participating in these separate but interrelated
traditions composed new texts to popular songs, known in France as
vaudevilles, and parodied airs from contemporary spectacles,
especially from the Opera. By interrogating the daily lives of
early modern Parisians through the lens of song production and
performance, I trace a cultural phenomenon in which individuals
recycled and reused bits of culture to form something new, whether
as a projection of their identity, as a means to satirically
critique society, as a demonstration of their wit, or as part of
complex social ceremonies. I first reconstruct the rich musical and
theatrical traditions that evolved in the public spaces of the
Pont-Neuf and Place Dauphine. I then turn to the theaters to
demonstrate that in the late seventeenth century playwrights
increasingly began to integrate street tunes into their productions
and to compose in the style of vaudevilles. Tunes from the theaters
were sometimes absorbed into the repertory of street performers and
became vaudevilles and Fairground plays drew from all currently
fashionable melodies. After establishing how popular tunes
functioned in the public sphere, I turn to song production at the
court and salons, where fashionable elites developed their own
tradition of parody. Just as street singers composed new satirical
texts to tunes from contemporary operas, participants at salons
composed witty texts to the most a la mode airs. In the final two
chapters, I reappraise the tradition of opera parody that emerged
at the Comedie-Francaise, Comedie-Italienne, and the theatres de la
foire. Armed with a more holistic understanding of the concept of
parody in the popular and elite song traditions, I argue that the
playwrights working at the Comedie-Francaise depicted and mocked
the parodic tradition from the salons, while also allowing servant
characters to connect the world on stage to the popular parody and
song traditions. In contrast, the Comedie-Italienne and theatres de
la foire, as popular public theaters, based their parody on the
more politicized satire fostered by ephemeral street
performances.
Advisors/Committee Members: Cowart, Georgia (Advisor).
Subjects/Keywords: Music; European History; Theater History; History; popular song; Louis XIV; Jean-Baptiste Lully; street song; early modern France; popular culture; French theater; Opera; Comedie-Francaise; Comedie-Italienne; Fairground theaters; theatres de la foire; mazarinades; street singing; popular theater; commedia
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Romey, John Andrew, I. (2018). Popular Song, Opera Parody, and the Construction of Parisian
Spectacle, 1648–1713. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338
Chicago Manual of Style (16th Edition):
Romey, John Andrew, III. “Popular Song, Opera Parody, and the Construction of Parisian
Spectacle, 1648–1713.” 2018. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338.
MLA Handbook (7th Edition):
Romey, John Andrew, III. “Popular Song, Opera Parody, and the Construction of Parisian
Spectacle, 1648–1713.” 2018. Web. 02 Mar 2021.
Vancouver:
Romey, John Andrew I. Popular Song, Opera Parody, and the Construction of Parisian
Spectacle, 1648–1713. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2018. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338.
Council of Science Editors:
Romey, John Andrew I. Popular Song, Opera Parody, and the Construction of Parisian
Spectacle, 1648–1713. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338
25.
Ivester, Clifford.
15-PGDH Inhibition in Reducing Chemotherapy Induced
Intestinal Mucositis and Increasing Hematopoietic Stem Cell
Transplant Efficiency.
Degree: MSs, Pathology, 2016, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171
► Gastrointestinal (GI) mucositis arises due to complications from clinical treatments associated with a variety of cancer types. Agents that promote protection or healing of these…
(more)
▼ Gastrointestinal (GI) mucositis arises due to
complications from clinical treatments associated with a variety of
cancer types. Agents that promote protection or healing of these
lesions could be beneficial in the clinical setting as they would
allow normal issues that arise with mucositis to be avoided.
Similarly, many forms of bone marrow cancer often require a
hematopoietic stem cell transplant (HSCT) which comes with a host
of issues for patients such as risk of infection or development of
Graft-versus-Host disease (GVHD), and there is a need to increase
the safety of transplants and manage the major side effects
associated with them. Prostaglandin PGE2 is a signaling molecule
able to both support proliferation of many cell types as well as
decrease inflammation. A 15-hydroxyprostaglandin dehydrogenase
(15-PGDH) inhibitor has been developed (SW033291) which prevents
15-PGDH from degrading prostaglandins causing a stark increase of
PGE2 levels in vivo. Here we show that by co-treating mice with
both high dose chemotherapy and SW033291, there is a reduction in
the severity of mucositis these mice develop when compared to high
dose chemotherapy alone. Here we also show that 15-PGDH inhibition
also causes increases in HSCT homing efficiency in both autologous
and syngeneic transplant types.
Advisors/Committee Members: Markowitz, Sanford (Advisor).
Subjects/Keywords: Biology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ivester, C. (2016). 15-PGDH Inhibition in Reducing Chemotherapy Induced
Intestinal Mucositis and Increasing Hematopoietic Stem Cell
Transplant Efficiency. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171
Chicago Manual of Style (16th Edition):
Ivester, Clifford. “15-PGDH Inhibition in Reducing Chemotherapy Induced
Intestinal Mucositis and Increasing Hematopoietic Stem Cell
Transplant Efficiency.” 2016. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171.
MLA Handbook (7th Edition):
Ivester, Clifford. “15-PGDH Inhibition in Reducing Chemotherapy Induced
Intestinal Mucositis and Increasing Hematopoietic Stem Cell
Transplant Efficiency.” 2016. Web. 02 Mar 2021.
Vancouver:
Ivester C. 15-PGDH Inhibition in Reducing Chemotherapy Induced
Intestinal Mucositis and Increasing Hematopoietic Stem Cell
Transplant Efficiency. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171.
Council of Science Editors:
Ivester C. 15-PGDH Inhibition in Reducing Chemotherapy Induced
Intestinal Mucositis and Increasing Hematopoietic Stem Cell
Transplant Efficiency. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171
26.
Zimmerman, Yuru Li.
Developing a Lightweight Martian Simulant and a Miniature
Triaxial Device for Lunar and Martian Soils.
Degree: PhD, Civil Engineering, 2016, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905
► A major frontier of space exploration is to construct permanent bases and test beds for future lunar and Martian exploration. Two essential components are in…
(more)
▼ A major frontier of space exploration is to construct
permanent bases and test beds for future lunar and Martian
exploration. Two essential components are in situ resource
utilization and surface mobility. In situ resource utilization
describes the usage of native lunar and Martian materials to reduce
construction costs on site. Surface mobility is study of the
interaction between soil and vehicle traction systems to develop
effective lunar or Martian vehicles. Both of these entities call
for a thorough understanding of the mechanical and engineering
properties of lunar and Martian soils. However, only limited
information has been gained so far with regard to the physical and
mechanical properties of lunar and Martian soil. This dissertation
discusses the development of a new miniature triaxial testing
device to investigate the shear strength of dry cohesionless soil
(lunar soil and lunar simulants) of less than 10 g, and comparisons
are made between the testing results and that achieved through
conventional triaxial tests to confirm the validity of the device.
In addition, a light weight Martian soil simulant, CWRU-1, was also
developed for large quantity application for the study of high
shrinkage mobility tests. CWRU-1 was mechanically characterized via
laboratory experiments and compared to characterizations of Martian
soil and previously developed Martian soil simulants.
Advisors/Committee Members: Zeng, Xiangwu (Committee Chair).
Subjects/Keywords: Civil Engineering
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zimmerman, Y. L. (2016). Developing a Lightweight Martian Simulant and a Miniature
Triaxial Device for Lunar and Martian Soils. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905
Chicago Manual of Style (16th Edition):
Zimmerman, Yuru Li. “Developing a Lightweight Martian Simulant and a Miniature
Triaxial Device for Lunar and Martian Soils.” 2016. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905.
MLA Handbook (7th Edition):
Zimmerman, Yuru Li. “Developing a Lightweight Martian Simulant and a Miniature
Triaxial Device for Lunar and Martian Soils.” 2016. Web. 02 Mar 2021.
Vancouver:
Zimmerman YL. Developing a Lightweight Martian Simulant and a Miniature
Triaxial Device for Lunar and Martian Soils. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905.
Council of Science Editors:
Zimmerman YL. Developing a Lightweight Martian Simulant and a Miniature
Triaxial Device for Lunar and Martian Soils. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905
27.
Niemi, Jon Paul.
Macrophage Accumulation Near Injured Neuronal Cell Bodies is
Necessary and Sufficient for Peripheral Axon Regeneration.
Degree: PhD, Neurosciences, 2017, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895
► Neuroinflammation plays a critical role in peripheral nerve regeneration. An injury to the sciatic nerve leads to macrophage accumulation in the L5 dorsal root ganglion…
(more)
▼ Neuroinflammation plays a critical role in peripheral
nerve regeneration. An injury to the sciatic nerve leads to
macrophage accumulation in the L5 dorsal root ganglion (DRG), an
effect notably not seen when axons in the L5 dorsal root are
injured. We have found that macrophage accumulation around
axotomized DRG cell bodies is necessary for the conditioning lesion
response. After axotomy, DRG neurons upregulate expression of CCL2,
a macrophage chemokine, which acts on the receptor CCR2. We found
that in a CCR2 knockout mouse, macrophage accumulation is inhibited
after injury in the distal sciatic nerve and in the DRG. To
determine the effect of this lack of macrophage accumulation on
regeneration, DRGs were placed in explant culture 1 week after a
conditioning lesion, and the increase in outgrowth seen in
previously lesioned DRGs from wild type mice was not seen in CCR2
-/- mice. These data demonstrate the role CCL2/CCR2 signaling plays
in mediating macrophage accumulation in DRGs and suggest a
relationship between macrophage accumulation near neuronal cell
bodies and the regenerative capacity of neurons. Axotomy leads to
many changes in DRGs. To probeixthe importance of CCL2 upregulation
alone, we overexpressed CCL2 in DRG neurons of uninjured mice using
a viral vector (AAV5) and asked whether this is sufficient to cause
macrophage accumulation and to enhance regeneration or whether
other injury-induced signals are necessary. Two different viral
constructs were used: an experimental virus coding for CCL2 and a
control virus coding for YFP. The viral constructs were delivered
intrathecally. AAV5-CCL2 led to a time-dependent increase in both
CCL2 mRNA expression and macrophage accumulation in the L5 DRG
compared to the YFP control virus. In addition, CCL2 overexpression
led to a conditioning-like increase in neurite outgrowth in both
DRG explants and in dissociated DRG neurons. AAV-CCL2 also
increased LIF mRNA in the DRG and increased neuronal phospho-STAT3.
Blockade of STAT3 activation by the inhibitor STATTIC completely
ablated the CCL2 overexpression-induced increase in axonal
regeneration. Together, our data suggests that neuronal CCL2
expression and macrophage accumulation within the DRG are both
necessary and sufficient for peripheral axonal regeneration to
occur.
Advisors/Committee Members: Zigmond, Richard (Advisor), Broihier, Heather (Committee Chair).
Subjects/Keywords: Neurobiology; Neurosciences; Regeneration; Axotomy; Macrophage; Neuroinflammation; CCL2; MCP-1; DRG
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Niemi, J. P. (2017). Macrophage Accumulation Near Injured Neuronal Cell Bodies is
Necessary and Sufficient for Peripheral Axon Regeneration. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895
Chicago Manual of Style (16th Edition):
Niemi, Jon Paul. “Macrophage Accumulation Near Injured Neuronal Cell Bodies is
Necessary and Sufficient for Peripheral Axon Regeneration.” 2017. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895.
MLA Handbook (7th Edition):
Niemi, Jon Paul. “Macrophage Accumulation Near Injured Neuronal Cell Bodies is
Necessary and Sufficient for Peripheral Axon Regeneration.” 2017. Web. 02 Mar 2021.
Vancouver:
Niemi JP. Macrophage Accumulation Near Injured Neuronal Cell Bodies is
Necessary and Sufficient for Peripheral Axon Regeneration. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2017. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895.
Council of Science Editors:
Niemi JP. Macrophage Accumulation Near Injured Neuronal Cell Bodies is
Necessary and Sufficient for Peripheral Axon Regeneration. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895
28.
Song, Qihuan, Song.
BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA.
Degree: MSs, Chemical Engineering, 2016, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900
► Copper is an essential micronutrient for the growth of flora and fauna; however, higher levels of copper (Cu II) from agricultural and other industrial waste…
(more)
▼ Copper is an essential micronutrient for the growth of
flora and fauna; however, higher levels of copper (Cu II) from
agricultural and other industrial waste are highly toxic to humans.
The goal of this project is to evaluate microalgae C. Sorokiniana
biomass as a low-cost option to remove low levels of copper through
biosorption in aqueous solutions. Our results show that the algae
biomass is very effective at removing copper from both high (10
g/l) and low (1 g/l) concentration solutions. The biosorption was
found to be a function of solution pH (lower pH has a lower
absorption capacity) and contact time. Further, C. Sorokiniana was
shown to absorb 100% copper equivalent to its weight. Collectively,
our results show that C. Sorokiniana biomass biosorption is a
promising low cost strategy in removing copper from effluent
streams.
Advisors/Committee Members: Baskaran, Harihara (Advisor).
Subjects/Keywords: Chemical Engineering; Civil Engineering; Copper,biosorption,biomass
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APA (6th Edition):
Song, Qihuan, S. (2016). BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900
Chicago Manual of Style (16th Edition):
Song, Qihuan, Song. “BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA.” 2016. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900.
MLA Handbook (7th Edition):
Song, Qihuan, Song. “BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA.” 2016. Web. 02 Mar 2021.
Vancouver:
Song, Qihuan S. BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900.
Council of Science Editors:
Song, Qihuan S. BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900
29.
Keshav, Arvind.
TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS
USING A CALCIUM-SENSITIVE FLUORESCENT DYE.
Degree: MSs (Engineering), Biomedical Engineering, 2016, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261
► Analysis of the neural activity in the hippocampus in the presence of epileptogenic agents shows fast-moving spikes sensitive to N-Methyl-D-Aspartate (NMDA) coming from a putative…
(more)
▼ Analysis of the neural activity in the hippocampus in
the presence of epileptogenic agents shows fast-moving spikes
sensitive to N-Methyl-D-Aspartate (NMDA) coming from a putative
electrically silent source moving at a slower speed and difficult
to track with standard fluorescence methods. Advances in imaging
technology have allowed for millisecond-resolution mapping of the
changes in fluorescence with high spatial resolution. In this
study, the presence of this electrically silent focus was revealed
by mapping the increase in intracellular calcium using the
calcium-sensitive fluorescent dye Oregon Green 488 BAPTA-1 (OGB-1).
Results indicate that the focus and its propagation can indeed be
tracked using OGB-1, with a mean propagation velocity, obtained by
cross-correlation calculations, of 0.0036 ± 0.0009 m/s, well within
the predicted range for the putative source from other indirect
measurements. Additionally, we tested in vitro the hypothesis that
the propagation of this focus was independent of the NMDA-sensitive
spikes it generates. The NMDA blocker introduced prevented the
generation of spikes, but the movement of the focus was unaffected.
The mean propagation velocity was 0.0035 ± 0.001 m/s and t-test
results showed no significant difference in propagation speeds with
and without the NMDA blocker. Together, these results indicate that
the electrically silent focus is indeed the source of the spikes
and relies on a different unknown mechanism of propagation. A
possible mechanism of propagation is through the diffusion of
potassium. However, the speed of the potassium wave was found to be
significantly lower than that observed for our source
(P<0.0001). These results indicate the presence of a novel
calcium wave in the hippocampus propagating through pyramidal cells
and capable of generating NMDA-sensitive spikes.
Advisors/Committee Members: Durand, Dominique (Advisor).
Subjects/Keywords: Biomedical Engineering; Biomedical Research; epilepsy; electrically silent source; calcium-sensitive fluorescent dyes; NMDA
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Keshav, A. (2016). TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS
USING A CALCIUM-SENSITIVE FLUORESCENT DYE. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261
Chicago Manual of Style (16th Edition):
Keshav, Arvind. “TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS
USING A CALCIUM-SENSITIVE FLUORESCENT DYE.” 2016. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261.
MLA Handbook (7th Edition):
Keshav, Arvind. “TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS
USING A CALCIUM-SENSITIVE FLUORESCENT DYE.” 2016. Web. 02 Mar 2021.
Vancouver:
Keshav A. TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS
USING A CALCIUM-SENSITIVE FLUORESCENT DYE. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261.
Council of Science Editors:
Keshav A. TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS
USING A CALCIUM-SENSITIVE FLUORESCENT DYE. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261
30.
Yin, Kezhen.
POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC
APPLICATIONS.
Degree: PhD, Macromolecular Science and Engineering, 2016, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841
► Chapter 1: Performance of new polymer nanolayer GRIN system with a high temperature polymer, OKP4HT, was evaluated. A combination of extruded nanolayered GRIN film systems,…
(more)
▼ Chapter 1: Performance of new polymer nanolayer GRIN
system with a high temperature polymer, OKP4HT, was evaluated. A
combination of extruded nanolayered GRIN film systems, comprised of
a total of five different materials, were combined to produce
optical laminates with a high refractive index range, 1.445 –
1.630. The optical performance of a series of varied magnitude GRIN
lenses was evaluated. Refractive index distribution and surface
profile of the GRIN lenses match the expected designed value.
Increasing the lens refractive index range resulted in decreased
spherical aberrations following analytical optical predictions. An
analytical approach was reported to correlate the polymer material
UST to the onset of polymer material loss modulus as measured by
DMTA. Thermo-optical interferometry measurements of irreversible
lens deformation confirmed the lenses upper service temperature
(UST) as 125°C for the OKP4HT/PC system as compared to 75°C for an
PMM/SAN17 systems.Chapter 2: Inspired by the soft, deformable human
eye lens, a synthetic polymer GRIN lens with an adaptive geometry
and focal power has been demonstrated via extrusion and
thermoforming of nanolayered elastomeric polymer films. Polymer
nanolayered films comprised of two thermoplastic polyurethanes with
a refractive index difference of 0.05 were co-extruded via forced
assembly technique. The set of thirty nanolayered polymer films
exhibited transmission near 90% with each film varying in
refractive index by 0.0017 as a result of the nanolayering
arrangement. An adaptive GRIN lens was fabricated from a laminated
stack of the variable refractive index films with a 0.05 spherical
gradient refractive index distribution and mechanically
deformability based on mechanical compression of the lens.
Variation in the optical properties, 20% variation in focal length
and reduced spherical aberration, of the deformable GRIN lens were
measured and simulated by placido-cone topography and ANSYS
methods. The demonstration of a solid state, dynamic focal length,
GRIN lens with improved aberration correction was discussed in
contact of potential future implantable devices.Chapter 3: Enhanced
dielectric properties were achieved through interface/interphase
modulation and biaxial orientation for the poly(ethylene
terephthalate)/poly(methyl methacrylate)/poly(vinylidene
fluoride-co-hexafluoropropylene) [PET/PMMA/P(VDF-HFP)]
three-component multilayer films. Because PMMA is miscible with
P(VDF-HFP) and compatible with PET, the interfacial adhesion
between PET and P(VDF-HFP) layers was greatly improved. Biaxial
stretching of the as-extruded multilayer films induced formation of
highly oriented fibrillar crystals in both P(VDF-HFP) and PET.
There were several effects resulted from biaxial orientation.
First, the parallel orientation of PVDF crystals reduced the
dielectric loss from the ac relaxation in a crystals. Second,
biaxial stretching constrained the amorphous phase in P(VDF-HFP)
and thus the migrational loss from impurity ions was reduced.
Third, biaxial stretching…
Advisors/Committee Members: Baer, Eric (Committee Chair).
Subjects/Keywords: Plastics; Engineering
Record Details
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Record Details
Similar Records
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yin, K. (2016). POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC
APPLICATIONS. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841
Chicago Manual of Style (16th Edition):
Yin, Kezhen. “POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC
APPLICATIONS.” 2016. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841.
MLA Handbook (7th Edition):
Yin, Kezhen. “POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC
APPLICATIONS.” 2016. Web. 02 Mar 2021.
Vancouver:
Yin K. POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC
APPLICATIONS. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841.
Council of Science Editors:
Yin K. POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC
APPLICATIONS. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841
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