publisher:("Case Western Reserve University School of Graduate Studies")

1. AL-Hamed, Arwa Abdulaziz. THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION, ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN WITH CHRONIC KIDNEY DISEASE.

Degree: PhD, Nursing, 2019, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292

► The aim of this study was to examine the relationship between executive function (EF), adaptive function (AF), academic achievement (AA), and to identify their relationship… (more)

▼ The aim of this study was to examine the relationship between executive function (EF), adaptive function (AF), academic achievement (AA), and to identify their relationship with health related quality of life (HRQOL) in children with chronic kidney disease (CKD). A cross-sectional design was used for this secondary data analysis of children from across the United States and Canada with mild to moderate CKD who receive care at hospitals associated with the Chronic Kidney Disease in Children study (CKiD). Data were collected using the Conner’s Continuous Performance Testing-II, Behavior Rating Inventory of Executive Functioning (BRIEF), Behavior Assessment System for Children-2, Wechsler Individual Achievement Test-II-Abbreviated and Pediatric Quality of Life Inventory. The children (N= 243) were mostly between 13 to 17 years of age (45%), 75 %, were Caucasian and 59% were male. A majority of the mothers (55%) had some college or baccalaureate degree and a household income above 31,000% annually (74%). The majority of children (76%) had a type of non-glomerular CKD; 50 % had CKD Stage 2 & 3. Children with CKD had lower HRQOL compared to their healthy peers with school functioning being the most affected area. Most scores for the EF, AF, and AA placed children with CKD within an age-appropriate range. However, there was a high percentage of children (23%- 43%) scoring more than 1 SD below the mean for EF, AF, and AA, indicating an increased risk for neurocognitive impairments. The hierarchical multiple regression analysis indicated that EF, AF, and AA accounted for 36 % of the variance in HRQOL but increased to 40% of the variance with the addition of covariates. Poor EF (Global Executive Composite), AF (Internalizing Problems [e.g. depressive symptoms, and anxiety]), and AA significantly predicted lower HRQOL. With the addition of covariates, only EF and AF remained significant, while high maternal education significantly predicted higher HRQOL, and anemia significantly predicted lower HRQOL. While the mediation effect of AA on the relationship between EF and HRQOL was not supported in this study, the results suggest that AF (Internalizing Problems) partially mediated the relationship between EF and HRQOL. This study underscores the need for an interdisciplinary approach (school nurses, teachers, psychologists, pediatric nephrologist) to tailor interventions that optimize EF, AF, and AA, and enhance HRQOL in children with mild to moderate CKD. Advisors/Committee Members: Toly , Valerie (Committee Chair).

Subjects/Keywords: Health Care; Nursing

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APA (6^th Edition):

AL-Hamed, A. A. (2019). THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION, ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN WITH CHRONIC KIDNEY DISEASE. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292

Chicago Manual of Style (16^th Edition):

AL-Hamed, Arwa Abdulaziz. “THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION, ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN WITH CHRONIC KIDNEY DISEASE.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292.

MLA Handbook (7^th Edition):

AL-Hamed, Arwa Abdulaziz. “THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION, ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN WITH CHRONIC KIDNEY DISEASE.” 2019. Web. 02 Mar 2021.

Vancouver:

AL-Hamed AA. THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION, ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN WITH CHRONIC KIDNEY DISEASE. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292.

Council of Science Editors:

AL-Hamed AA. THE INFLUENCE OF EXECUTIVE FUNCTION, ADAPTIVE FUNCTION, ACADEMIC ACHIEVEMENT ON HEALTH RELATED QUALITY OF LIFE IN CHILDREN WITH CHRONIC KIDNEY DISEASE. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555099896433292

2. Hiznay, James Matthew. Molecular Analyses of DDX41 in the Spliceosome and Myeloid Neoplasms.

Degree: PhD, Molecular Medicine, 2019, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859

► Within the past decade, links between RNA splicing and myeloid neoplasms have emerged in the basic and clinical literature. DDX41 is a putative DEAD-box RNA… (more)

▼ Within the past decade, links between RNA splicing and myeloid neoplasms have emerged in the basic and clinical literature. DDX41 is a putative DEAD-box RNA helicase involved in the function of the spliceosome. Like several spliceosomal factors, mutations in DDX41 are observed in myelodysplastic syndrome (MDS). Uniquely, heterozygous frameshift DDX41 mutations can occur in the germ line of MDS patients with or without somatic missense mutations in the other allele. We cataloged MDS patients with somatic and germ line DDX41 mutations. Relative to MDS patients lacking a DDX41 mutation, our patient cohort had fewer co-mutations in epigenetic modulators, but co-mutations in DNA repair factors were increased. We examined the role of DDX41 perturbations on gene expression and splicing. We found that DDX41 binds to pre-mRNAs near splice sites and to some spliceosomal snRNAs, notably U2 and U12. Recombinant DDX41 protein was shown to have double-stranded RNA unwinding and ATP hydrolytic activities. Recombinant protein with the recurrent somatic mutation p.Arg525His (p.R525H) bound RNA about fourfold better but unwound RNA about fourfold slower than wild type. Nuclear extract created from DDX41-deficient leukemic cells spliced RNA approximately threefold slower than nuclear extract derived from HeLa cells. In cell lines, both knockdown of DDX41 and expression of p.R525H mutant DDX41 led to changes in splicing and expression in a variety of genes. These changes were similar to the changes seen in cell lines with mutations in the MDS-associated splicing factors SF3B1 and U2AF1. Global splicing analyses suggested that DDX41 delays intron removal, perhaps as part of a proofreading step, while the p.R525H mutant has a dominant negative stimulatory effect on splicing. We also saw that DDX41 perturbations affected the levels of many other spliceosomal factors, likely producing a cellular environment permissive for aberrant splicing events. Advisors/Committee Members: Padgett, Richard (Advisor), Luse, Donal (Committee Chair).

Subjects/Keywords: Biochemistry; Genetics; Health Sciences; Molecular Biology; Oncology; Biomedical Research; DDX41; splicing; MDS

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APA (6^th Edition):

Hiznay, J. M. (2019). Molecular Analyses of DDX41 in the Spliceosome and Myeloid Neoplasms. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859

Chicago Manual of Style (16^th Edition):

Hiznay, James Matthew. “Molecular Analyses of DDX41 in the Spliceosome and Myeloid Neoplasms.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859.

MLA Handbook (7^th Edition):

Hiznay, James Matthew. “Molecular Analyses of DDX41 in the Spliceosome and Myeloid Neoplasms.” 2019. Web. 02 Mar 2021.

Vancouver:

Hiznay JM. Molecular Analyses of DDX41 in the Spliceosome and Myeloid Neoplasms. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859.

Council of Science Editors:

Hiznay JM. Molecular Analyses of DDX41 in the Spliceosome and Myeloid Neoplasms. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555347987446859

3. Yang, Lingyu. In-Situ Synthesis of Well-Defined Silver Nanoparticles in Water Soluble Polymer Matrix.

Degree: MSs, Macromolecular Science and Engineering, 2019, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208

► In this thesis, spin-coated pure PVA films and PVA/PVP blend films were used as solid-state polymer matrix, and embedded silver nanoparticles were synthesized by ultraviolet… (more)

Subjects/Keywords: Nanoscience

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APA (6^th Edition):

Yang, L. (2019). In-Situ Synthesis of Well-Defined Silver Nanoparticles in Water Soluble Polymer Matrix. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208

Chicago Manual of Style (16^th Edition):

Yang, Lingyu. “In-Situ Synthesis of Well-Defined Silver Nanoparticles in Water Soluble Polymer Matrix.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208.

MLA Handbook (7^th Edition):

Yang, Lingyu. “In-Situ Synthesis of Well-Defined Silver Nanoparticles in Water Soluble Polymer Matrix.” 2019. Web. 02 Mar 2021.

Vancouver:

Yang L. In-Situ Synthesis of Well-Defined Silver Nanoparticles in Water Soluble Polymer Matrix. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208.

Council of Science Editors:

Yang L. In-Situ Synthesis of Well-Defined Silver Nanoparticles in Water Soluble Polymer Matrix. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1555418297166208

4. Samorezov, Julia Elizabeth. Hydrogels with Controlled Physical and Biochemical Properties to Direct Cell Behavior for Applications in Bone Tissue Engineering.

Degree: PhD, Biomedical Engineering, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088

► Tissue engineered bone grafts using biomaterials, autologous cells and bioactive factors seek to address the clinical need for replacement bone tissue to treat musculoskeletal injuries.… (more)

▼ Tissue engineered bone grafts using biomaterials, autologous cells and bioactive factors seek to address the clinical need for replacement bone tissue to treat musculoskeletal injuries. This dissertation aimed to use hydrogel biomaterial scaffolds to present either biochemical signals or patterns of physical properties to influence the behavior of cells with known osteogenic potential, with the ultimate goal of expanding knowledge of the cells’ responses to such signals and developing instructive biomaterials for bone regeneration. Human adipose-derived stem cells (hASCs) were used because of their known capacity for osteogenic differentiation, but there are conflicting data on their response to specific potentially osteogenic soluble factors. To address this, dexamethasone and bone morphogenetic protein-2 (BMP-2) were examined for their effects on osteogenic differentiation of hASCs from three donors in 2D culture and in 3D methacrylated gelatin (GelMA) hydrogels. Culture medium with a lower calcium concentration than standard DMEM was shown to be beneficial in revealing these effects. Media supplementation with BMP-2 did not improve hASC osteogenesis. Dexamethasone was shown to be highly osteogenic, but the addition of BMP-2 to culture media inhibited this dexamethasone-driven hASC osteogenic differentiation. It was next examined if sustained, localized presentation of BMP-2 could enhance its osteogenic potential compared to exogenous presentation from culture medium. When BMP-2 was mixed into GelMA hydrogels prior to crosslinking, approximately one third of the loaded growth factor was retained in the hydrogels for seven weeks. Delivery from the hydrogel did improve BMP-2 bioactivity, leading to statistically increased calcium deposition compared to similar amounts of growth factor supplied exogenously in culture medium. Lastly, a dual-crosslinked alginate hydrogel system was developed to spatially control hydrogel physical properties or presentation of covalently coupled cell adhesive peptides. Changes in biomaterial stiffness and swelling significantly affected preosteoblast cell proliferation, and spatial control over RGD cell adhesion peptide presentation directed both cell adhesion and proliferation. This system can easily be applied to control the spatial presentation of osteogenic signals to hASCs, providing a platform to study cell response to patterned physical and biochemical signals or serving as an instructive biomaterial to guide hASC osteogenesis. Advisors/Committee Members: Alsberg, Eben (Advisor).

Subjects/Keywords: Biomedical Engineering

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APA (6^th Edition):

Samorezov, J. E. (2015). Hydrogels with Controlled Physical and Biochemical Properties to Direct Cell Behavior for Applications in Bone Tissue Engineering. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088

Chicago Manual of Style (16^th Edition):

Samorezov, Julia Elizabeth. “Hydrogels with Controlled Physical and Biochemical Properties to Direct Cell Behavior for Applications in Bone Tissue Engineering.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088.

MLA Handbook (7^th Edition):

Samorezov, Julia Elizabeth. “Hydrogels with Controlled Physical and Biochemical Properties to Direct Cell Behavior for Applications in Bone Tissue Engineering.” 2015. Web. 02 Mar 2021.

Vancouver:

Samorezov JE. Hydrogels with Controlled Physical and Biochemical Properties to Direct Cell Behavior for Applications in Bone Tissue Engineering. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088.

Council of Science Editors:

Samorezov JE. Hydrogels with Controlled Physical and Biochemical Properties to Direct Cell Behavior for Applications in Bone Tissue Engineering. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435241088

5. Bury, Luke Andrew Dascenzo. Examining Dynamic Aspects of Presynaptic Terminal Formation via Live Confocal Microscopy.

Degree: PhD, Pharmacology, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355

► To create a presynaptic terminal, molecular signaling events must be orchestrated within a number of subcellular compartments. In the soma, presynaptic proteins need to be… (more)

Subjects/Keywords: Neurosciences; Neurobiology; Biomedical Research; Developmental Biology; presynaptic; synaptogenesis; synapse formation; axonal transport; live imaging; confocal microscopy; neuroligin; neurexin

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APA (6^th Edition):

Bury, L. A. D. (2015). Examining Dynamic Aspects of Presynaptic Terminal Formation via Live Confocal Microscopy. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355

Chicago Manual of Style (16^th Edition):

Bury, Luke Andrew Dascenzo. “Examining Dynamic Aspects of Presynaptic Terminal Formation via Live Confocal Microscopy.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355.

MLA Handbook (7^th Edition):

Bury, Luke Andrew Dascenzo. “Examining Dynamic Aspects of Presynaptic Terminal Formation via Live Confocal Microscopy.” 2015. Web. 02 Mar 2021.

Vancouver:

Bury LAD. Examining Dynamic Aspects of Presynaptic Terminal Formation via Live Confocal Microscopy. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355.

Council of Science Editors:

Bury LAD. Examining Dynamic Aspects of Presynaptic Terminal Formation via Live Confocal Microscopy. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435336355

6. Chen, Yang. DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY.

Degree: PhD, EECS - Computer Engineering, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642

► With the deluge of biomedical data, developing computational approaches for data analysis and interrogation has become a key step in translational biomedical research. It is… (more)

▼ With the deluge of biomedical data, developing computational approaches for data analysis and interrogation has become a key step in translational biomedical research. It is critical to leverage existing data to ask the right question and design algorithms for specific biomedical applications. This dissertation proposes a domain knowledge guided strategy for data gathering, data fusion and algorithm design in solving specific biomedical problems. This strategy is demonstrated in three distinct application contexts.The first application is retrieving disease manifestation images from the web for supporting patients' self-education and decision making. The challenge is three-fold: heterogeneous irrelevant web images need to be filtered; the positive examples of disease images contain diverse objects and complex backgrounds; and large amounts of manual efforts in generating training data are unaffordable. Based on a key observation that detecting disease-affected abnormal organs may greatly reduce the manual labeling efforts, our approach extracts the disease-organ semantic relationships from ontologies to guide the organ detection with pre-trained detectors. Comparing with a standard supervised method, our approach improved the average precision by 5% while reduced the manual efforts by 85%.The second application is developing disease-specific models to detect genetic basis for human diseases. We first develop a cross-species genetic network analysis approach to study the host-pathogen interactions in parasitic infectious diseases and predict disease associated genes. This approach was applied on malaria and demonstrated useful in guiding anti-malaria drug discovery. In the second phenome-driven approach, we explore a new disease phenotype data source in medical ontologies to construct the Disease Manifestation Network (DMN), and integrate multiple phenotype networks with genetic networks to predict genes. An application of this approach on Crohn's disease demonstrated the translational potential of the predicted genes in drug discovery. The third approach is identifying the mutual comorbidity for colorectal cancer and obesity in the comorbidity network to detect genetic basis for the link between the two diseases.The last application is drug repositioning based on combining disease genetics and mouse phenotype data. Disease associated genes have the potential to guide drug discovery. On the other hand, the mouse phenotypes provide knowledge on gene functions, which is impossible to be obtained in human. Our approach first identifies disease-specific mouse phenotypes using well-studied disease genes, and then search all FDA-approved drugs for the candidates that share similar mouse phenotype profiles with the disease.The approach was applied to predict drugs for Parkinson's disease, and achieved significant improvements comparing with a state-of-art approach based on mouse phenotype data.In summary, this dissertation demonstrates the effectiveness of computational algorithms in translational biomedical research. It… Advisors/Committee Members: Guo-qiang, Zhang (Committee Chair), Rong, Xu (Advisor).

Subjects/Keywords: Computer Science; Biomedical Research; Computer Engineering; computational approach; translational biomedical research; image retrieval; disease gene prediction; drug repositioning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, Y. (2015). DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642

Chicago Manual of Style (16^th Edition):

Chen, Yang. “DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642.

MLA Handbook (7^th Edition):

Chen, Yang. “DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY.” 2015. Web. 02 Mar 2021.

Vancouver:

Chen Y. DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642.

Council of Science Editors:

Chen Y. DEVELOPMENT OF COMPUTATIONAL APPROACHES FOR MEDICAL IMAGE RETRIEVAL, DISEASE GENE PREDICTION, AND DRUG DISCOVERY. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435601642

7. Vithayathil, Joseph. Developmental and Post-natal Roles for ERK1/2 Signaling in the Hippocampus.

Degree: PhD, Neurosciences, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090

► The ERK/MAPK pathway is an intracellular signaling pathway that mediates many cellular functions. Mutations in the different elements of this pathway lead to a variety… (more)

▼ The ERK/MAPK pathway is an intracellular signaling pathway that mediates many cellular functions. Mutations in the different elements of this pathway lead to a variety of congenital disorders termed neuro-cardio-facial-cutaneous syndromes (NCFC). These disorders result in many overlapping features including various levels of intellectual disability and cognitive function. In addition, dysregulation of the ERK/MAPK pathway has been implicated in other cognitive and behavioral disorders such as autism, schizophrenia and major depression. Understanding the role of this pathway during development and maturation of the brain will provide critical insight into the pathophysiology of these disorders.The ERK/MAPK pathway has previously been shown to regulate proliferation of neural progenitors during cortical development. Furthermore, pharmacologic studies inhibiting the ERK/MAPK pathway resulted in impaired synaptic plasticity and spatial memory. These studies have identified potential roles for ERK signaling during development and neurophysiologic functions in the hippocampus. The hippocampus is a critical mediator of memory formation and hippocampal volume is altered in various cognitive and behavioral disorders. An important question that remains to be answered is identifying the relative contributions from developmental and post-natal dysregulation of the MAPK pathway in the hippocampus as it relates to the pathophysiology of cognitive deficits observed in NCFC and related syndromes.In examining the development of the hippocampus, we observe that loss of both ERK1 and ERK2 isoforms impairs morphogenesis of the hippocampus resulting in a dentate gyrus that is 1/3 the size of a normal dentate gyrus by post-natal day 10. Furthermore, this phenotype is due to the precocious maturation of radial glial cells and depletion of progenitor populations in the germinal zones that generate the granule cells of the dentate gyrus. Interestingly, the presence of ERK1 is sufficient for normal development of the hippocampus, as knockouts of ERK2 alone do not affect hippocampal morphogenesis. Finally, to examine possible post-natal effects from loss of ERK2 we utilized the developmental ERK2 knockout mice and a post-natal ERK2 knockout mouse to show that the loss of ERK2 does not result in major changes to memory or long-term potentiation in the hippocampus. Interestingly, the post-natal knockout of ERK2 can affect recognition memory and causes delayed spatial learning, but LTP remains intact. These findings show that ERK1 is sufficient for normal development and memory functions of the hippocampus. Furthermore, developmental knockouts of ERK2 appear to perform better than post-natal knockouts of ERK2 in some memory retention tasks suggesting that developmental adaptions from loss of ERK signaling may ameliorate necessity for ERK signaling. These findings highlight the necessity of examining the effects of chronic dysregulation of signaling pathways that regulate hippocampal function, as these phenotypes may be vastly different from… Advisors/Committee Members: Deneris, Evan (Committee Chair), Landreth, Gary (Advisor).

Subjects/Keywords: Biomedical Research; Molecular Biology; dentate gyrus development; neurogenesis; MAPK pathway; NCFC syndromes; synaptic plasticity; memory formation

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APA (6^th Edition):

Vithayathil, J. (2015). Developmental and Post-natal Roles for ERK1/2 Signaling in the Hippocampus. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090

Chicago Manual of Style (16^th Edition):

Vithayathil, Joseph. “Developmental and Post-natal Roles for ERK1/2 Signaling in the Hippocampus.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090.

MLA Handbook (7^th Edition):

Vithayathil, Joseph. “Developmental and Post-natal Roles for ERK1/2 Signaling in the Hippocampus.” 2015. Web. 02 Mar 2021.

Vancouver:

Vithayathil J. Developmental and Post-natal Roles for ERK1/2 Signaling in the Hippocampus. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090.

Council of Science Editors:

Vithayathil J. Developmental and Post-natal Roles for ERK1/2 Signaling in the Hippocampus. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1435760090

8. Bakhshiani, Mehran. A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM FORBROADBAND DIELECTRIC SPECTROSCOPY.

Degree: PhD, EECS - Electrical Engineering, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857

► This project has developed two integrated microsystems fabricated in a 0.35-µm two-poly four-metal RF CMOS process for miniaturized broadband dielectric spectroscopy. In particular, first, a… (more)

▼ This project has developed two integrated microsystems fabricated in a 0.35-µm two-poly four-metal RF CMOS process for miniaturized broadband dielectric spectroscopy. In particular, first, a broadband sensor interface IC as part of a miniaturized measurement platform for MHz-to-GHz dielectric spectroscopy has been developed. The IC measures frequency-dependent S21 magnitude and phase of a microfluidic dielectric sensor fabricated in a thick gold-on-glass microfabrication process and loaded with a material-under-test (MUT). The sensor interfaced with the IC is fully capable of differentiating among deionized (DI) water, phosphate buffered saline (PBS), ethanol and methanol in tests conducted at four different excitation frequencies of 50 MHz, 500 MHz, 1 GHz and 3 GHz. Further, dielectric readings of ethanol from the sensor interfaced with the IC at five excitation frequencies in the range of 50 MHz to 2 GHz are in excellent agreement (error < 1%) with those from using a vector network analyzer (VNA) as the sensor readout.Next, a self-sustained, miniaturized, microfluidic-CMOS platform for palmtop dielectric spectroscopy has been developed. The platform incorporates a parallel-plate capacitive sensor with a three-dimensional gap, floating electrode, and microfluidic channel for sample delivery, as well as a fully integrated transceiver for broadband dielectric spectroscopy. The IC applies a single-tone sinusoidal RF excitation signal in a frequency range of ~ 9MHz to 2.433GHz to the MUT-loaded sensor, and measures the sensor transmission characteristics in the voltage domain via an amplitude/phase measurement utilizing broadband frequency response analysis (bFRA) to extract the MUT complex permittivity with microliter sample volumes. Complex dielectric readings of PBS from the platform at six excitation frequencies in the range of 50 MHz to 2.4 GHz are in excellent agreement (RMS error <1.5% for 0.5 to 2.4 GHz) with those from a reference measurement by an Agilent 85070E dielectric probe kit interfaced with a VNA.Finally, an autonomous self-sustained palmtop platform, incorporating the microfluidic-CMOS platform, ADC, power supply unit, Wi-Fi module, and a Raspberry Pi computing module has been developed. The palmtop platform is capable of accurately measuring the real and imaginary parts of MUT complex permittivity from ~ 9MHz to 2.433GHz in less than 5s, enabling rapid, high-throughput, and low-cost measurements with a self-sustained, portable platform that can pave the way for translating dielectric spectroscopy from the lab bench to the field or the bedside. Advisors/Committee Members: Mohseni, Pedram (Advisor).

Subjects/Keywords: Engineering; Integrated Circuit, Broadband Dielectric Spectroscopy, Sensor, Microfluidic, CMOS, Miniaturized, Transceiver

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APA (6^th Edition):

Bakhshiani, M. (2015). A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM FORBROADBAND DIELECTRIC SPECTROSCOPY. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857

Chicago Manual of Style (16^th Edition):

Bakhshiani, Mehran. “A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM FORBROADBAND DIELECTRIC SPECTROSCOPY.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857.

MLA Handbook (7^th Edition):

Bakhshiani, Mehran. “A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM FORBROADBAND DIELECTRIC SPECTROSCOPY.” 2015. Web. 02 Mar 2021.

Vancouver:

Bakhshiani M. A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM FORBROADBAND DIELECTRIC SPECTROSCOPY. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857.

Council of Science Editors:

Bakhshiani M. A SELF-SUSTAINED MINIATURIZED MICROFLUIDIC-CMOS PLATFORM FORBROADBAND DIELECTRIC SPECTROSCOPY. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436266857

9. Dermawan, Josephine Kam Tai. From NF-κB to FACT: Mechanisms and Translational Applications of EGFR-mediated NF-κB Regulation.

Degree: PhD, Molecular Medicine, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263

► The epidermal growth factor receptor (EGFR) drives downstream signaling pathways that promote cancer progression. EGFR is often constitutively active in tumors, e.g., non-small cell lung… (more)

▼ The epidermal growth factor receptor (EGFR) drives downstream signaling pathways that promote cancer progression. EGFR is often constitutively active in tumors, e.g., non-small cell lung cancer (NSCLC) and glioblastoma (GBM), either by overexpression or mutations. Nuclear factor-κB (NF-κB) is a master transcription factor that controls inflammation and innate immunity. NF-κB, often constitutively activated in cancer, drives tumor development by activating antiapoptotic and prosurvival genes, and has been implicated in anticancer drug resistance. We and others have shown that EGFR activates NF-κB signaling in both noncancerous and cancer cells. In an attempt to overcome drug resistance to EGFR tyrosine kinase inhibitors (TKI): erlotinib and lapatinib in NSCLC and GBM respectively, we combined EGFR-TKI with a novel class of NF-κB inhibitors, including quinacrine and curaxins, which inhibit NF-κB-driven transcription by targeting the facilitates chromatin transcription (FACT) complex. Unexpectedly, we discovered preferential targeting of GBM stem cells (GSCs), another major player in cancer therapeutic resistance, by curaxins, uncovering a potential role of FACT in the maintenance of stem cell phenotypes. Beyond applications in anticancer therapeutics, we are interested in the basic biological question of how EGFR, compared to canonical NF-κB activators such as interleukin 1 (IL-1), regulates NF-κB distinctively. Specifically, we utilize genomic approaches including RNA-sequencing (RNA-sequencing) and chromatin immunoprecipitation (ChIP)-sequencing to investigate the signal-specific, genome-wide regulation of NF-κB-driven transcription by EGFR versus IL-1. One possible mechanism that underlies specificity in transcription factor regulation is differential phosphorylation. We speculate that phosphorylation of the serine 276 residue on the NF-κB subunit p65 (RELA) plays a role in EGFR-mediated NF-κB regulation. Using the gene editing approach CRISPR, we have introduced the genetic mutation S276A in the RELA gene. In the next phase, we plan to interrogate the impact of this mutation in EGFR-mediated NF-κB regulation. In addition, we will interrogate whether STAT3, a major oncogene also activated by EGFR, serves as a transcriptional coregulator in the context of NF-κB-driven transcription. Taken together, these studies elucidate how EGFR regulates NF-κB on a genomic level, which remains poorly understood, and have major implications in anticancer therapy and drug resistance, especially in cancers driven by EGFR and/or NF-κB. Advisors/Committee Members: Stark, George (Advisor), Jackson, Mark (Committee Chair).

Subjects/Keywords: Cellular Biology; Molecular Biology; Oncology; Genetics; ChIP-seq; CRISPR; epidermal growth factor receptor, EGFR; curaxins; facilitates chromatin transcription, FACT; glioblastoma; GBM stem cell; nuclear factor kappa B, NF-kappaB; non-small cell lung cancer; quinacrine; RNA-seq; transcriptional regulation

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APA (6^th Edition):

Dermawan, J. K. T. (2015). From NF-κB to FACT: Mechanisms and Translational Applications of EGFR-mediated NF-κB Regulation. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263

Chicago Manual of Style (16^th Edition):

Dermawan, Josephine Kam Tai. “From NF-κB to FACT: Mechanisms and Translational Applications of EGFR-mediated NF-κB Regulation.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263.

MLA Handbook (7^th Edition):

Dermawan, Josephine Kam Tai. “From NF-κB to FACT: Mechanisms and Translational Applications of EGFR-mediated NF-κB Regulation.” 2015. Web. 02 Mar 2021.

Vancouver:

Dermawan JKT. From NF-κB to FACT: Mechanisms and Translational Applications of EGFR-mediated NF-κB Regulation. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263.

Council of Science Editors:

Dermawan JKT. From NF-κB to FACT: Mechanisms and Translational Applications of EGFR-mediated NF-κB Regulation. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263

10. Zimmerman, Grant Robert. T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS.

Degree: MSs, Pathology, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859

► Recent characterization of the bone marrow microenvironment has pointed to comprehensive dysregulation of hematopoietic-stromal interactions in the context of leukemia. We used common oncogenic mutations… (more)

Subjects/Keywords: Pathology; Medicine; Molecular Biology; Bone Marrow; Stromal Cells; Acute Lymphoblastic Leukemia; T-ALL; CXCR4; Notch; Leukemic Stem Cell

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APA (6^th Edition):

Zimmerman, G. R. (2015). T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859

Chicago Manual of Style (16^th Edition):

Zimmerman, Grant Robert. “T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859.

MLA Handbook (7^th Edition):

Zimmerman, Grant Robert. “T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS.” 2015. Web. 02 Mar 2021.

Vancouver:

Zimmerman GR. T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859.

Council of Science Editors:

Zimmerman GR. T-ALL LEUKEMIA DYSREGULATES STROMAL BONE MARROW ENVIRONMENT AND DISRUPTS NICHE-STEM CELL SIGNALING AXIS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436293859

11. HUANG, LING-YI. Electronic Band Structure, Phonons and Exciton Binding Energies of Halide Perovskites CsSnX₃ with X=Cl, Br, I.

Degree: PhD, Physics, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745

► Halide perovskites (ABX₃) have attracted a large amount of attention since 2009 due to their important applications in solar cells. Though high power conversion efficiencies… (more)

Subjects/Keywords: Physics

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APA (6^th Edition):

HUANG, L. (2015). Electronic Band Structure, Phonons and Exciton Binding Energies of Halide Perovskites CsSnX₃ with X=Cl, Br, I. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745

Chicago Manual of Style (16^th Edition):

HUANG, LING-YI. “Electronic Band Structure, Phonons and Exciton Binding Energies of Halide Perovskites CsSnX₃ with X=Cl, Br, I.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745.

MLA Handbook (7^th Edition):

HUANG, LING-YI. “Electronic Band Structure, Phonons and Exciton Binding Energies of Halide Perovskites CsSnX₃ with X=Cl, Br, I.” 2015. Web. 02 Mar 2021.

Vancouver:

HUANG L. Electronic Band Structure, Phonons and Exciton Binding Energies of Halide Perovskites CsSnX₃ with X=Cl, Br, I. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745.

Council of Science Editors:

HUANG L. Electronic Band Structure, Phonons and Exciton Binding Energies of Halide Perovskites CsSnX₃ with X=Cl, Br, I. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436477745

12. Alouani, David James. THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS.

Degree: MSs, Systems Biology and Bioinformatics, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267

► The main goal of the present effort is to develop a comprehensive computational and statistical framework for analyzing large scale proteomics data and understand the… (more)

Subjects/Keywords: Bioinformatics; Biology; Biostatistics; Computer Science; Aging

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APA (6^th Edition):

Alouani, D. J. (2015). THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267

Chicago Manual of Style (16^th Edition):

Alouani, David James. “THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267.

MLA Handbook (7^th Edition):

Alouani, David James. “THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS.” 2015. Web. 02 Mar 2021.

Vancouver:

Alouani DJ. THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267.

Council of Science Editors:

Alouani DJ. THE AGING PROCESS OF C. ELEGANS VIEWED THROUGH TIME DEPENDENT PROTEIN EXPRESSION ANALYSIS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436393267

13. Trinh, Tat To. REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION ELEMENTS AND miRNAs.

Degree: PhD, Biochemistry, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986

► Messenger (mRNA) deadenylation is thought to be rate limiting for and to trigger of mRNA decay, either 5’ to 3’ or 3’ to 5’. In… (more)

▼ Messenger (mRNA) deadenylation is thought to be rate limiting for and to trigger of mRNA decay, either 5’ to 3’ or 3’ to 5’. In a survey of polyA tail length of specific mRNAs in Drosophila S2 cells, we found several, including reaper and arc-1 mRNAs, that exhibited very short or non-existent polyA tails. Knockdown of deadenylase components revealed that reaper mRNAs were synthesized with normal polyA tails, a result in which indicated that the tail-less mRNAs had been rapidly deadenylated. Maintenance of capped but deadenylated state in the reaper mRNA requires three cis-acting elements in the 3' UTR. Interestingly, arc- 1 transcripts are found to be insensitive to deadenylases depletion, strongly suggesting that they are not ever polyadenylated. More surprisingly, these deadenylated mRNAs were found to be fully associated with actively translating ribosomes. Disaggregation of polysomes under hypertonic conditions followed by recovery in isotonic conditions shows that the deadenylated mRNAs can be efficiently translated. To rule out the possibility of reinitiation of translation required the full polyA tail, we treated S2 cells with harringtonine and showed accumulation of deadenylated species on 80S fraction. For these and possibly other mRNAs, a polyA tail is not required for translation.The mechanism whereby microRNAs (miRNAs) repress protein output from targeted mRNAs remains in question. Substantive evidence indicates that miRNAs function primarily, if not exclusively, by destabilizing their mRNA targets. Whether destabilization is the consequence of inhibition of initiation of translation is still debated. Other evidence has suggested that miRNAs inhibit translation at some step after initiation but mechanistic insight into how this could occur has been difficult to obtain. The notion that miRNAs impact translation post initiation derives largely from many observations that miRNA targets and miRNAs themselves appear to be associated with actively translating ribosomes. The vast majority of studies that had examined mechanism of miRNA-mediated repression have been carried out using transient transfection of both targets and miRNAs; most often with engineered 3' UTRs. Here, we made stable cell lines expressing the well-characterized miRNA-targeted 3' UTRs of Drosophila reaper and hid. Lines expressing two versions of each UTR, one with wild type miRNA recognition sites, and one where the recognition sites were mutated, were studied. All detectable mRNAs from all four lines were associated with actively translating ribosomes as assessed by harringtonine treatment and northern blotting. Half-life measurements showed that mRNAs containing wild type miRNA recognition sites were dramatically destabilized when compared to those with mutant recognition sites. When transcription was arrested, we observed a rapid accumulation of mRNA fragments. These fragments resulted from progressive truncation from the 5' end of the mRNA and were ribosome associated. These data indicate that mRNA-mediated mRNA destabilization and… Advisors/Committee Members: Nilsen, Timothy (Advisor), Coller, Jeffery (Committee Chair).

Subjects/Keywords: Biochemistry; deadenylation, miRNA, mRNA destabilization, cotranslational mRNA decay

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APA (6^th Edition):

Trinh, T. T. (2015). REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION ELEMENTS AND miRNAs. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986

Chicago Manual of Style (16^th Edition):

Trinh, Tat To. “REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION ELEMENTS AND miRNAs.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986.

MLA Handbook (7^th Edition):

Trinh, Tat To. “REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION ELEMENTS AND miRNAs.” 2015. Web. 02 Mar 2021.

Vancouver:

Trinh TT. REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION ELEMENTS AND miRNAs. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986.

Council of Science Editors:

Trinh TT. REGULATION OF DROSOPHILA mRNA STABILITY BY DEADENYLATION ELEMENTS AND miRNAs. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436441986

14. Bezik, Cody. Poly(High Internal Phase Emulsion) Foams and Fibers: Structure-Property Relationships.

Degree: MSs (Engineering), Chemical Engineering, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970

► Poly(high internal phase emulsions) are highly porous open-cell foams formed by emulsion templating. These foams have many applications, but the fundamental relationship of emulsion properties… (more)

Subjects/Keywords: Chemical Engineering; Polymers; High internal phase emulsion; polymeric monoliths; emulsion stability; porous fibers

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APA (6^th Edition):

Bezik, C. (2015). Poly(High Internal Phase Emulsion) Foams and Fibers: Structure-Property Relationships. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970

Chicago Manual of Style (16^th Edition):

Bezik, Cody. “Poly(High Internal Phase Emulsion) Foams and Fibers: Structure-Property Relationships.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970.

MLA Handbook (7^th Edition):

Bezik, Cody. “Poly(High Internal Phase Emulsion) Foams and Fibers: Structure-Property Relationships.” 2015. Web. 02 Mar 2021.

Vancouver:

Bezik C. Poly(High Internal Phase Emulsion) Foams and Fibers: Structure-Property Relationships. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970.

Council of Science Editors:

Bezik C. Poly(High Internal Phase Emulsion) Foams and Fibers: Structure-Property Relationships. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436458970

15. Salwiesz, Michael C. The Impact of Parent Involvement on the Education of Children: Unlocking the Role of Parent Involvement in Promoting Academic Achievement Among Racially Diverse Kindergarteners.

Degree: PhD, Social Welfare, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483

► The literature overwhelmingly supports the benefits of education. Nevertheless, the reality of the modern education system is that all students do not have an equal… (more)

▼ The literature overwhelmingly supports the benefits of education. Nevertheless, the reality of the modern education system is that all students do not have an equal chance of attaining the education that has so much transformative power. A significant achievement gap between minority and low-income students and their European-American and more affluent peers continues to produce inequalities in the educational and life course outcomes for minority and low-income students throughout the United States. In an effort to address these inequities, federal initiatives have emphasized the role of parents in the education of their children and have included parents in nearly every policy initiative aimed at improving academic achievement for the past 50 years. Even though parent involvement has received tremendous support, there is limited evidence on the specific dimensions of parent involvement that impact academic achievement, the impact of parent involvement on diverse groups, and the impact of parent involvement on the achievement gap.This study utilized the ecological systems theory and Epstein’s Theory of Overlapping Spheres to examine the relationship between parent involvement and academic achievement on racially diverse kindergarteners (N=13,655). This study utilized hierarchical linear modeling and data from the Early Childhood Longitudinal Study, Kindergarten Class (ECLS-K). The dataset was selected because it collects information on parent involvement and academic achievement variables, while the overwhelming majority of datasets focus exclusively on one set of variables. This study found that parent involvement has a tremendous positive impact on both reading and math achievement, but fell short of supporting the notion that all forms of parent involvement are beneficial. Furthermore, this study found significant differences in the relationship between parent involvement and academic achievement by race. After more than a half-century recognizing the importance of parent involvement, we are still at the beginning stages of truly understanding how to unlock the full potential of parent involvement on academic achievement for all learners. This dissertation is a call to all educators, policymakers, and researchers to unlock the full potential of parent involvement to raise academic achievement for all students, with a special emphasis on mitigating the inequities throughout the education system. Advisors/Committee Members: Joseph, Mark (Committee Chair).

Subjects/Keywords: Education; Social Work; Parent Involvement; Kindergarten; Multilevel Modeling; Academic Achievement

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APA (6^th Edition):

Salwiesz, M. C. (2015). The Impact of Parent Involvement on the Education of Children: Unlocking the Role of Parent Involvement in Promoting Academic Achievement Among Racially Diverse Kindergarteners. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483

Chicago Manual of Style (16^th Edition):

Salwiesz, Michael C. “The Impact of Parent Involvement on the Education of Children: Unlocking the Role of Parent Involvement in Promoting Academic Achievement Among Racially Diverse Kindergarteners.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483.

MLA Handbook (7^th Edition):

Salwiesz, Michael C. “The Impact of Parent Involvement on the Education of Children: Unlocking the Role of Parent Involvement in Promoting Academic Achievement Among Racially Diverse Kindergarteners.” 2015. Web. 02 Mar 2021.

Vancouver:

Salwiesz MC. The Impact of Parent Involvement on the Education of Children: Unlocking the Role of Parent Involvement in Promoting Academic Achievement Among Racially Diverse Kindergarteners. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483.

Council of Science Editors:

Salwiesz MC. The Impact of Parent Involvement on the Education of Children: Unlocking the Role of Parent Involvement in Promoting Academic Achievement Among Racially Diverse Kindergarteners. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436443483

16. Aranjuez, George Gil Fajardo. Cellular Mechanisms that Promote the Collective Migratory Behavior of Drosophila Border Cells.

Degree: PhD, Genetics, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488

► Collective migration is a type of cell movement wherein groups of cells move together as a coherent unit. Collective migration is involved in multiple aspects… (more)

▼ Collective migration is a type of cell movement wherein groups of cells move together as a coherent unit. Collective migration is involved in multiple aspects of development across many organisms. Different forms of collective migration are observed in many biological processes such as gastrulation, tubulogenesis, neural crest migration and wound healing. Cancer cells can also spread via collective migration in the form of cellular streams. The hallmark of collective migration is the action of cellular mechanisms that control and shape the motility of the individual cells in the group. Despite the broad impact on normal development and disease, the molecular mechanisms that facilitate collective migration are still not well understood. I used border cell migration in the Drosophila ovary to study the mechanisms that promote collective movement. Border cell migration occurs in the egg chamber, which is composed of an oocyte and supportive nurse cells enveloped by a monolayer of follicle cell epithelium. During oogenesis, border cells originate from the follicle epithelium, assemble into a cluster of 4-6 cells and migrate in a ligand-guided fashion in between the nurse cells to reach the oocyte. Through a genetic screen, I identified new genes that are important for border cell migration. One of these genes, the serine/threonine kinase drop out (dop), promotes the stereotypic migratory behavior of the border cell cluster. Dop mutant border cell clusters extend ectopic protrusions and fail to complete migration. In vivo, collectively migrating cells maintain group cohesion while negotiating various physical hindrances such as the extracellular matrix or other cells. Border cell clusters squeeze in between larger cell types while maintaining a compact shape. I discovered waves of actomyosin contractility at the periphery of the cluster. Loss of peripheral actomyosin contractility leads to the deformation of the cluster and failure to complete migration. It is important to identify these supracellular mechanisms to understand collective migration. Advisors/Committee Members: McDonald, Jocelyn (Advisor), Salz, Helen (Committee Chair).

Subjects/Keywords: Cellular Biology; Developmental Biology; collective migration; Drosophila; border cells; myosin; oogenesis; drop out

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APA (6^th Edition):

Aranjuez, G. G. F. (2015). Cellular Mechanisms that Promote the Collective Migratory Behavior of Drosophila Border Cells. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488

Chicago Manual of Style (16^th Edition):

Aranjuez, George Gil Fajardo. “Cellular Mechanisms that Promote the Collective Migratory Behavior of Drosophila Border Cells.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488.

MLA Handbook (7^th Edition):

Aranjuez, George Gil Fajardo. “Cellular Mechanisms that Promote the Collective Migratory Behavior of Drosophila Border Cells.” 2015. Web. 02 Mar 2021.

Vancouver:

Aranjuez GGF. Cellular Mechanisms that Promote the Collective Migratory Behavior of Drosophila Border Cells. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488.

Council of Science Editors:

Aranjuez GGF. Cellular Mechanisms that Promote the Collective Migratory Behavior of Drosophila Border Cells. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436369488

17. Sun, Mengmeng. COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR VISUALIZING SNOMED CT FRAGMENTS.

Degree: MSs, EECS - Computer and Information Sciences, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297

► Many clinical ontology search interfaces have been developed to provide access to ontological information. However, existing search interfaces are insufficient for ontology quality assurance work.… (more)

Subjects/Keywords: Computer Science; SNOMED CT; web design; search interface

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APA (6^th Edition):

Sun, M. (2015). COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR VISUALIZING SNOMED CT FRAGMENTS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297

Chicago Manual of Style (16^th Edition):

Sun, Mengmeng. “COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR VISUALIZING SNOMED CT FRAGMENTS.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297.

MLA Handbook (7^th Edition):

Sun, Mengmeng. “COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR VISUALIZING SNOMED CT FRAGMENTS.” 2015. Web. 02 Mar 2021.

Vancouver:

Sun M. COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR VISUALIZING SNOMED CT FRAGMENTS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297.

Council of Science Editors:

Sun M. COBE: A CONJUNCTIVE ONTOLOGY BROWSER AND EXPLORER FOR VISUALIZING SNOMED CT FRAGMENTS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436373297

18. Schinaman, Joseph Moeller. INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN DROSOPHILA.

Degree: PhD, Biology, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103

► Courtship is a behavior common to many species in which members of one gender advertise to the other their species identity and overall fitness. In… (more)

▼ Courtship is a behavior common to many species in which members of one gender advertise to the other their species identity and overall fitness. In many species, the male courts the female, and the male’s courtship display provides a complex array of auditory, visual and olfactory information to the courted female, which must be decoded to generate the decision to accept or reject the potential mate. However, despite the centrality of courtship behavior to the evolution and maintenance of species, relatively little is known about the genetic and neural circuitry underlying female mate choice. To investigate this process in detail, we have analyzed the courtship acceptance behavior of Drosophila melanogaster, a species in which females are presented with multimodal sensory information during courtship. In this work, we show that Drosophila females mutant for the Kruppel-like transcription factor datilografo (dati) are incapable of accepting males, despite eliciting normal courtship from them. To facilitate further study of this gene’s role in patterning the brain for acceptance behavior, we used a novel system to perform clonal analyses of genes on the fourth chromosome, the genomic location of dati. The analysis of Drosophila females bearing labelled patches of dati mutant tissue throughout the brain revealed three regions where this transcription factor is required for normal acceptance behavior: the antennal lobe of the anterior brain, and two regions flanking the lateral2horn in the posterior brain. These regions encompass areas of olfactory signal processing and sensory integration, respectively. In addition to the experiments above, we carried out an RNA interference screen to determine the neurotransmitter profile of dati neurons required for female acceptance behavior. This screen revealed that dati is required in cholinergic neurons. Finally, to determine precisely the position and number of individual neurons that mediate female acceptance behavior in the regions identified, we determined which dati neurons were cholinergic. Ultimately we found around 60 neuron spread across three regions. In whole, this work highlights indispensable and tractably-sized areas of the overall courtship acceptance circuit, and supports a stimuli-summation mechanism of courtship acceptance. Advisors/Committee Members: Mizutani, Claudia (Advisor), Sousa-Nves, Rui (Advisor).

Subjects/Keywords: Biology; Neurobiology

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APA (6^th Edition):

Schinaman, J. M. (2015). INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN DROSOPHILA. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103

Chicago Manual of Style (16^th Edition):

Schinaman, Joseph Moeller. “INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN DROSOPHILA.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103.

MLA Handbook (7^th Edition):

Schinaman, Joseph Moeller. “INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN DROSOPHILA.” 2015. Web. 02 Mar 2021.

Vancouver:

Schinaman JM. INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN DROSOPHILA. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103.

Council of Science Editors:

Schinaman JM. INVESTIGATING THE MECHANISM OF COURTSHIP ACCEPTANCE IN DROSOPHILA. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436446103

19. Chen, Xi. SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING EMBRYOGENESIS IN ZEBRAFISH.

Degree: MSs, Biology, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069

► Mechanotransduction is involved in many physiological functions such as touch, hearing, and pain. A variety of tissues and organs have been shown to be mechanosensitive,… (more)

Subjects/Keywords: Biology

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APA (6^th Edition):

Chen, X. (2015). SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING EMBRYOGENESIS IN ZEBRAFISH. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069

Chicago Manual of Style (16^th Edition):

Chen, Xi. “SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING EMBRYOGENESIS IN ZEBRAFISH.” 2015. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069.

MLA Handbook (7^th Edition):

Chen, Xi. “SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING EMBRYOGENESIS IN ZEBRAFISH.” 2015. Web. 02 Mar 2021.

Vancouver:

Chen X. SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING EMBRYOGENESIS IN ZEBRAFISH. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069.

Council of Science Editors:

Chen X. SPATIOTEMPORAL EXPRESSION PATTERNS OF CHANNELS DURING EMBRYOGENESIS IN ZEBRAFISH. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436474069

20. Fecteau, Ryan E. Genome-wide Approaches for Discovery of Novel Genetic and Epigenetic Events in Gastrointestinal Cancer.

Degree: PhD, Pathology, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464

► Cancer is a disease caused by the sequential acquisition of genetic and epigenetic changes that transform a normal cell into an ungovernable malignancy. Advances in… (more)

▼ Cancer is a disease caused by the sequential acquisition of genetic and epigenetic changes that transform a normal cell into an ungovernable malignancy. Advances in technologies to interrogate these changes on a genome-wide scale have reshaped our understanding of this disease and rapidly expanded the field of cancer genomics. The objective of the projects described herein was to adapt high-throughput methods to discover and characterize novel genetic and epigenetic events in gastrointestinal cancers with the intention of translational application. Three primary studies comprise the body of this thesis. In the first, we identify recurrent mutations in the oncogene GNAS found by sequencing of the colorectal cancer genome. Targeted pyrosequencing of GNAS in a colon cancer tumor cohort established a mutation frequency in colorectal cancer of around 2%. By comparing GNAS mutation status with clinical and pathologic data, we found that GNAS mutations associate with a distinct class of colon cancers that are characterized by concomitant KRAS or BRAF mutations, by location in the proximal colon, and by a unique association with a villous morphology. The second study applied a targeted next generation sequencing approach, whole exome sequencing, to identify a germ-line susceptibility variant in a familial syndrome of Barrett’s esophagus and esophageal adenocarcinoma. Sequencing revealed a private variant in the uncharacterized gene VSIG10L that segregated with disease in a large familial Barrett’s esophagus family and functional studies suggested the discovered variant disrupted maturation of the normal esophageal epithelium. Lastly, we describe using reduced representation bisulfite sequencing to examine the colon cancer methylome for candidate methylated biomarker loci. Preliminary data from this work has identified 3 candidate methylated DNA biomarkers for potential use in detection of colorectal cancer in patient plasma. Cumulatively, these studies have identified a rare mutation in colon cancer associated with a unique molecular phenotype, a private germ-line variant predisposing to familial Barrett’s esophagus and adenocarcinoma, and candidate methylated biomarkers for detection and monitoring of colon cancer, all of which are of potential clinical importance. Advisors/Committee Members: Markowitz, Sanford (Advisor).

Subjects/Keywords: Pathology; Genetics; Oncology; Gastrointestinal cancer; translational; next generation sequencing; colon cancer; Barretts esophagus; esophageal adenocarcinoma

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APA (6^th Edition):

Fecteau, R. E. (2015). Genome-wide Approaches for Discovery of Novel Genetic and Epigenetic Events in Gastrointestinal Cancer. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464

Chicago Manual of Style (16^th Edition):

Fecteau, Ryan E. “Genome-wide Approaches for Discovery of Novel Genetic and Epigenetic Events in Gastrointestinal Cancer.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464.

MLA Handbook (7^th Edition):

Fecteau, Ryan E. “Genome-wide Approaches for Discovery of Novel Genetic and Epigenetic Events in Gastrointestinal Cancer.” 2015. Web. 02 Mar 2021.

Vancouver:

Fecteau RE. Genome-wide Approaches for Discovery of Novel Genetic and Epigenetic Events in Gastrointestinal Cancer. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464.

Council of Science Editors:

Fecteau RE. Genome-wide Approaches for Discovery of Novel Genetic and Epigenetic Events in Gastrointestinal Cancer. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1436549464

21. Gregory, Jill Christine. Transmission of Atherosclerosis and Thrombosis Susceptibility with Gut Microbial Transplantation.

Degree: PhD, Molecular Medicine, 2015, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679

► The overall goal of my thesis research is to further the understanding of the link among dietary trimethylamine-containing nutrients, intestinal microbiome, and cardiovascular disease (CVD)… (more)

▼ The overall goal of my thesis research is to further the understanding of the link among dietary trimethylamine-containing nutrients, intestinal microbiome, and cardiovascular disease (CVD) by testing the hypothesis that disease susceptibility is a transmissible trait via cecal microbial transplant. The positive correlation discovered between plasma TMAO and lesion in a panel of inbred mouse strains permitted the identification of atherosclerosis prone (high TMAO-producing, large lesion; C57BL/6J) and resistant mice (low TMAO-producing, small lesion; NZW/LacJ) to be used as donor strains for cecal microbial transplant into intestinal microbiota-suppressed recipient C57BL/6J Apoe-/- female mice. Recipients of C57BL/6J microbes on the choline diet initially had statistically significantly higher plasma TMA and TMAO as compared to choline diet NZW/LacJ recipients, and at the study endpoint, choline diet-dependent enhancement of atherosclerotic lesion area was observed in the recipients of C57BL/6J microbes but not in recipients of NZW/LacJ microbes. Examination of microbial communities from 16S rRNA bacterial gene sequencing analysis showed distinct donor communities faithfully transferred to the respective recipient mouse groups. Several donor strain-characteristic taxa were identified in recipient groups whose proportional abundances correlated with plasma TMAO and/or lesion area. The second set of studies explores thrombosis potential and platelet reactivity, the proximal events in heart attack and stroke, for a relationship with the microbiome. Plasma TMAO is associated with a 2-fold increased risk for thrombotic events in a large cohort (n=4007). TMAO enhances agonist dependent platelet responsiveness by increasing the release of intracellular calcium stores. In mice, provision of TMAO or dietary choline (solely in the setting of an intact microbial community) enhances platelet aggregation ex vivo and shortens the time to cessation of blood flow in vivo. Cecal microbial transplant study showed that germ-free recipients of the disease-prone donor microbes were transmitted bacterial communities, choline diet-dependent enhanced TMA lyase activity, elevated plasma TMAO, and prothrombotic phenotypes as compared to recipients of disease-resistant donors. Collectively, the results of these studies suggest that the body and its microbial inhabitants interact to promote health or disease. Targeting microbial communities could be an adjunct treatment for the management of cardiometabolic disease in the future. Advisors/Committee Members: Hazen, Stanley (Advisor), Kirwan, John (Committee Chair).

Subjects/Keywords: Biochemistry; Biomedical Research; Biology; Bioinformatics; Ecology; Health; Microbiology; Molecular Biology; Nutrition; Atherosclerosis; Choline; Dyslipidemia; Gut Microbiota; Koch Postulate; Lipid; Nutrition; Phospholipid; Thrombosis; Trimethylamine N-Oxide; TMAO

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APA (6^th Edition):

Gregory, J. C. (2015). Transmission of Atherosclerosis and Thrombosis Susceptibility with Gut Microbial Transplantation. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679

Chicago Manual of Style (16^th Edition):

Gregory, Jill Christine. “Transmission of Atherosclerosis and Thrombosis Susceptibility with Gut Microbial Transplantation.” 2015. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679.

MLA Handbook (7^th Edition):

Gregory, Jill Christine. “Transmission of Atherosclerosis and Thrombosis Susceptibility with Gut Microbial Transplantation.” 2015. Web. 02 Mar 2021.

Vancouver:

Gregory JC. Transmission of Atherosclerosis and Thrombosis Susceptibility with Gut Microbial Transplantation. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2015. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679.

Council of Science Editors:

Gregory JC. Transmission of Atherosclerosis and Thrombosis Susceptibility with Gut Microbial Transplantation. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1437067679

22. Guan, Dongyin. Post-transcriptional Regulation of PML protein by Distinct Mechanisms.

Degree: PhD, Biochemistry, 2016, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253

► The promyelocytic leukemia (PML) protein is a tumor suppressor originally identified in acute promyelocytic leukemia and implicated in tumorigenesis in multiple forms of cancer. PML… (more)

Subjects/Keywords: Biomedical Research; pml, miRNA, UHRF1, SIRT1, SIRT5

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APA (6^th Edition):

Guan, D. (2016). Post-transcriptional Regulation of PML protein by Distinct Mechanisms. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253

Chicago Manual of Style (16^th Edition):

Guan, Dongyin. “Post-transcriptional Regulation of PML protein by Distinct Mechanisms.” 2016. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253.

MLA Handbook (7^th Edition):

Guan, Dongyin. “Post-transcriptional Regulation of PML protein by Distinct Mechanisms.” 2016. Web. 02 Mar 2021.

Vancouver:

Guan D. Post-transcriptional Regulation of PML protein by Distinct Mechanisms. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253.

Council of Science Editors:

Guan D. Post-transcriptional Regulation of PML protein by Distinct Mechanisms. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1437410253

23. Han, Lu. Light Management in Photovoltaic Devices and Nanostructure Engineering in Nitride-based Optoelectronic Devices.

Degree: PhD, EECS - Electrical Engineering, 2017, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605

► Currently, there are several issues that limit the efficiency and performance of modern semiconductor optoelectronic devices. Photovoltaics are promising optoelectronic devices for generating electrical power… (more)

Subjects/Keywords: Electrical Engineering; Optics; Solid State Physics; Experiments; Physics; Light coupling; Interfacial coupling structures; Photovoltaics; Microdome structures; Concaved-dome structures; Nanostructure engineering; Optoelectric devices; LEDs; II-IV-nitride; III-nitride; Type-II QW; Near-IR quantum cascade laser

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APA (6^th Edition):

Han, L. (2017). Light Management in Photovoltaic Devices and Nanostructure Engineering in Nitride-based Optoelectronic Devices. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605

Chicago Manual of Style (16^th Edition):

Han, Lu. “Light Management in Photovoltaic Devices and Nanostructure Engineering in Nitride-based Optoelectronic Devices.” 2017. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605.

MLA Handbook (7^th Edition):

Han, Lu. “Light Management in Photovoltaic Devices and Nanostructure Engineering in Nitride-based Optoelectronic Devices.” 2017. Web. 02 Mar 2021.

Vancouver:

Han L. Light Management in Photovoltaic Devices and Nanostructure Engineering in Nitride-based Optoelectronic Devices. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2017. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605.

Council of Science Editors:

Han L. Light Management in Photovoltaic Devices and Nanostructure Engineering in Nitride-based Optoelectronic Devices. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1486996393294605

24. Romey, John Andrew, III. Popular Song, Opera Parody, and the Construction of Parisian Spectacle, 1648–1713.

Degree: PhD, Music History, 2018, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338

► This dissertation examines the interplay between popular and elite song traditions in early modern Paris. Individuals participating in these separate but interrelated traditions composed new… (more)

▼ This dissertation examines the interplay between popular and elite song traditions in early modern Paris. Individuals participating in these separate but interrelated traditions composed new texts to popular songs, known in France as vaudevilles, and parodied airs from contemporary spectacles, especially from the Opera. By interrogating the daily lives of early modern Parisians through the lens of song production and performance, I trace a cultural phenomenon in which individuals recycled and reused bits of culture to form something new, whether as a projection of their identity, as a means to satirically critique society, as a demonstration of their wit, or as part of complex social ceremonies. I first reconstruct the rich musical and theatrical traditions that evolved in the public spaces of the Pont-Neuf and Place Dauphine. I then turn to the theaters to demonstrate that in the late seventeenth century playwrights increasingly began to integrate street tunes into their productions and to compose in the style of vaudevilles. Tunes from the theaters were sometimes absorbed into the repertory of street performers and became vaudevilles and Fairground plays drew from all currently fashionable melodies. After establishing how popular tunes functioned in the public sphere, I turn to song production at the court and salons, where fashionable elites developed their own tradition of parody. Just as street singers composed new satirical texts to tunes from contemporary operas, participants at salons composed witty texts to the most a la mode airs. In the final two chapters, I reappraise the tradition of opera parody that emerged at the Comedie-Francaise, Comedie-Italienne, and the theatres de la foire. Armed with a more holistic understanding of the concept of parody in the popular and elite song traditions, I argue that the playwrights working at the Comedie-Francaise depicted and mocked the parodic tradition from the salons, while also allowing servant characters to connect the world on stage to the popular parody and song traditions. In contrast, the Comedie-Italienne and theatres de la foire, as popular public theaters, based their parody on the more politicized satire fostered by ephemeral street performances. Advisors/Committee Members: Cowart, Georgia (Advisor).

Subjects/Keywords: Music; European History; Theater History; History; popular song; Louis XIV; Jean-Baptiste Lully; street song; early modern France; popular culture; French theater; Opera; Comedie-Francaise; Comedie-Italienne; Fairground theaters; theatres de la foire; mazarinades; street singing; popular theater; commedia

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APA (6^th Edition):

Romey, John Andrew, I. (2018). Popular Song, Opera Parody, and the Construction of Parisian Spectacle, 1648–1713. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338

Chicago Manual of Style (16^th Edition):

Romey, John Andrew, III. “Popular Song, Opera Parody, and the Construction of Parisian Spectacle, 1648–1713.” 2018. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338.

MLA Handbook (7^th Edition):

Romey, John Andrew, III. “Popular Song, Opera Parody, and the Construction of Parisian Spectacle, 1648–1713.” 2018. Web. 02 Mar 2021.

Vancouver:

Romey, John Andrew I. Popular Song, Opera Parody, and the Construction of Parisian Spectacle, 1648–1713. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2018. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338.

Council of Science Editors:

Romey, John Andrew I. Popular Song, Opera Parody, and the Construction of Parisian Spectacle, 1648–1713. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1521213146521338

25. Ivester, Clifford. 15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency.

Degree: MSs, Pathology, 2016, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171

► Gastrointestinal (GI) mucositis arises due to complications from clinical treatments associated with a variety of cancer types. Agents that promote protection or healing of these… (more)

Subjects/Keywords: Biology

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APA (6^th Edition):

Ivester, C. (2016). 15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171

Chicago Manual of Style (16^th Edition):

Ivester, Clifford. “15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency.” 2016. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171.

MLA Handbook (7^th Edition):

Ivester, Clifford. “15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency.” 2016. Web. 02 Mar 2021.

Vancouver:

Ivester C. 15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171.

Council of Science Editors:

Ivester C. 15-PGDH Inhibition in Reducing Chemotherapy Induced Intestinal Mucositis and Increasing Hematopoietic Stem Cell Transplant Efficiency. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468405171

26. Zimmerman, Yuru Li. Developing a Lightweight Martian Simulant and a Miniature Triaxial Device for Lunar and Martian Soils.

Degree: PhD, Civil Engineering, 2016, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905

► A major frontier of space exploration is to construct permanent bases and test beds for future lunar and Martian exploration. Two essential components are in… (more)

Subjects/Keywords: Civil Engineering

11 more images…

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APA (6^th Edition):

Zimmerman, Y. L. (2016). Developing a Lightweight Martian Simulant and a Miniature Triaxial Device for Lunar and Martian Soils. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905

Chicago Manual of Style (16^th Edition):

Zimmerman, Yuru Li. “Developing a Lightweight Martian Simulant and a Miniature Triaxial Device for Lunar and Martian Soils.” 2016. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905.

MLA Handbook (7^th Edition):

Zimmerman, Yuru Li. “Developing a Lightweight Martian Simulant and a Miniature Triaxial Device for Lunar and Martian Soils.” 2016. Web. 02 Mar 2021.

Vancouver:

Zimmerman YL. Developing a Lightweight Martian Simulant and a Miniature Triaxial Device for Lunar and Martian Soils. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905.

Council of Science Editors:

Zimmerman YL. Developing a Lightweight Martian Simulant and a Miniature Triaxial Device for Lunar and Martian Soils. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468503905

27. Niemi, Jon Paul. Macrophage Accumulation Near Injured Neuronal Cell Bodies is Necessary and Sufficient for Peripheral Axon Regeneration.

Degree: PhD, Neurosciences, 2017, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895

► Neuroinflammation plays a critical role in peripheral nerve regeneration. An injury to the sciatic nerve leads to macrophage accumulation in the L5 dorsal root ganglion… (more)

▼ Neuroinflammation plays a critical role in peripheral nerve regeneration. An injury to the sciatic nerve leads to macrophage accumulation in the L5 dorsal root ganglion (DRG), an effect notably not seen when axons in the L5 dorsal root are injured. We have found that macrophage accumulation around axotomized DRG cell bodies is necessary for the conditioning lesion response. After axotomy, DRG neurons upregulate expression of CCL2, a macrophage chemokine, which acts on the receptor CCR2. We found that in a CCR2 knockout mouse, macrophage accumulation is inhibited after injury in the distal sciatic nerve and in the DRG. To determine the effect of this lack of macrophage accumulation on regeneration, DRGs were placed in explant culture 1 week after a conditioning lesion, and the increase in outgrowth seen in previously lesioned DRGs from wild type mice was not seen in CCR2 -/- mice. These data demonstrate the role CCL2/CCR2 signaling plays in mediating macrophage accumulation in DRGs and suggest a relationship between macrophage accumulation near neuronal cell bodies and the regenerative capacity of neurons. Axotomy leads to many changes in DRGs. To probeixthe importance of CCL2 upregulation alone, we overexpressed CCL2 in DRG neurons of uninjured mice using a viral vector (AAV5) and asked whether this is sufficient to cause macrophage accumulation and to enhance regeneration or whether other injury-induced signals are necessary. Two different viral constructs were used: an experimental virus coding for CCL2 and a control virus coding for YFP. The viral constructs were delivered intrathecally. AAV5-CCL2 led to a time-dependent increase in both CCL2 mRNA expression and macrophage accumulation in the L5 DRG compared to the YFP control virus. In addition, CCL2 overexpression led to a conditioning-like increase in neurite outgrowth in both DRG explants and in dissociated DRG neurons. AAV-CCL2 also increased LIF mRNA in the DRG and increased neuronal phospho-STAT3. Blockade of STAT3 activation by the inhibitor STATTIC completely ablated the CCL2 overexpression-induced increase in axonal regeneration. Together, our data suggests that neuronal CCL2 expression and macrophage accumulation within the DRG are both necessary and sufficient for peripheral axonal regeneration to occur. Advisors/Committee Members: Zigmond, Richard (Advisor), Broihier, Heather (Committee Chair).

Subjects/Keywords: Neurobiology; Neurosciences; Regeneration; Axotomy; Macrophage; Neuroinflammation; CCL2; MCP-1; DRG

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APA (6^th Edition):

Niemi, J. P. (2017). Macrophage Accumulation Near Injured Neuronal Cell Bodies is Necessary and Sufficient for Peripheral Axon Regeneration. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895

Chicago Manual of Style (16^th Edition):

Niemi, Jon Paul. “Macrophage Accumulation Near Injured Neuronal Cell Bodies is Necessary and Sufficient for Peripheral Axon Regeneration.” 2017. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895.

MLA Handbook (7^th Edition):

Niemi, Jon Paul. “Macrophage Accumulation Near Injured Neuronal Cell Bodies is Necessary and Sufficient for Peripheral Axon Regeneration.” 2017. Web. 02 Mar 2021.

Vancouver:

Niemi JP. Macrophage Accumulation Near Injured Neuronal Cell Bodies is Necessary and Sufficient for Peripheral Axon Regeneration. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2017. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895.

Council of Science Editors:

Niemi JP. Macrophage Accumulation Near Injured Neuronal Cell Bodies is Necessary and Sufficient for Peripheral Axon Regeneration. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1468589895

28. Song, Qihuan, Song. BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA.

Degree: MSs, Chemical Engineering, 2016, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900

► Copper is an essential micronutrient for the growth of flora and fauna; however, higher levels of copper (Cu II) from agricultural and other industrial waste… (more)

Subjects/Keywords: Chemical Engineering; Civil Engineering; Copper,biosorption,biomass

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APA (6^th Edition):

Song, Qihuan, S. (2016). BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900

Chicago Manual of Style (16^th Edition):

Song, Qihuan, Song. “BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA.” 2016. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900.

MLA Handbook (7^th Edition):

Song, Qihuan, Song. “BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA.” 2016. Web. 02 Mar 2021.

Vancouver:

Song, Qihuan S. BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900.

Council of Science Editors:

Song, Qihuan S. BIOSORPTION OF COPPER BY CHLORELLA SOROKINIANA. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469058900

29. Keshav, Arvind. TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS USING A CALCIUM-SENSITIVE FLUORESCENT DYE.

Degree: MSs (Engineering), Biomedical Engineering, 2016, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261

► Analysis of the neural activity in the hippocampus in the presence of epileptogenic agents shows fast-moving spikes sensitive to N-Methyl-D-Aspartate (NMDA) coming from a putative… (more)

Subjects/Keywords: Biomedical Engineering; Biomedical Research; epilepsy; electrically silent source; calcium-sensitive fluorescent dyes; NMDA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keshav, A. (2016). TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS USING A CALCIUM-SENSITIVE FLUORESCENT DYE. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261

Chicago Manual of Style (16^th Edition):

Keshav, Arvind. “TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS USING A CALCIUM-SENSITIVE FLUORESCENT DYE.” 2016. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261.

MLA Handbook (7^th Edition):

Keshav, Arvind. “TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS USING A CALCIUM-SENSITIVE FLUORESCENT DYE.” 2016. Web. 02 Mar 2021.

Vancouver:

Keshav A. TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS USING A CALCIUM-SENSITIVE FLUORESCENT DYE. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261.

Council of Science Editors:

Keshav A. TRACKING AN ELECTRICALLY SILENT SOURCE IN THE HIPPOCAMPUS USING A CALCIUM-SENSITIVE FLUORESCENT DYE. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469380261

30. Yin, Kezhen. POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC APPLICATIONS.

Degree: PhD, Macromolecular Science and Engineering, 2016, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841

► Chapter 1: Performance of new polymer nanolayer GRIN system with a high temperature polymer, OKP4HT, was evaluated. A combination of extruded nanolayered GRIN film systems,… (more)

▼ Chapter 1: Performance of new polymer nanolayer GRIN system with a high temperature polymer, OKP4HT, was evaluated. A combination of extruded nanolayered GRIN film systems, comprised of a total of five different materials, were combined to produce optical laminates with a high refractive index range, 1.445 – 1.630. The optical performance of a series of varied magnitude GRIN lenses was evaluated. Refractive index distribution and surface profile of the GRIN lenses match the expected designed value. Increasing the lens refractive index range resulted in decreased spherical aberrations following analytical optical predictions. An analytical approach was reported to correlate the polymer material UST to the onset of polymer material loss modulus as measured by DMTA. Thermo-optical interferometry measurements of irreversible lens deformation confirmed the lenses upper service temperature (UST) as 125°C for the OKP4HT/PC system as compared to 75°C for an PMM/SAN17 systems.Chapter 2: Inspired by the soft, deformable human eye lens, a synthetic polymer GRIN lens with an adaptive geometry and focal power has been demonstrated via extrusion and thermoforming of nanolayered elastomeric polymer films. Polymer nanolayered films comprised of two thermoplastic polyurethanes with a refractive index difference of 0.05 were co-extruded via forced assembly technique. The set of thirty nanolayered polymer films exhibited transmission near 90% with each film varying in refractive index by 0.0017 as a result of the nanolayering arrangement. An adaptive GRIN lens was fabricated from a laminated stack of the variable refractive index films with a 0.05 spherical gradient refractive index distribution and mechanically deformability based on mechanical compression of the lens. Variation in the optical properties, 20% variation in focal length and reduced spherical aberration, of the deformable GRIN lens were measured and simulated by placido-cone topography and ANSYS methods. The demonstration of a solid state, dynamic focal length, GRIN lens with improved aberration correction was discussed in contact of potential future implantable devices.Chapter 3: Enhanced dielectric properties were achieved through interface/interphase modulation and biaxial orientation for the poly(ethylene terephthalate)/poly(methyl methacrylate)/poly(vinylidene fluoride-co-hexafluoropropylene) [PET/PMMA/P(VDF-HFP)] three-component multilayer films. Because PMMA is miscible with P(VDF-HFP) and compatible with PET, the interfacial adhesion between PET and P(VDF-HFP) layers was greatly improved. Biaxial stretching of the as-extruded multilayer films induced formation of highly oriented fibrillar crystals in both P(VDF-HFP) and PET. There were several effects resulted from biaxial orientation. First, the parallel orientation of PVDF crystals reduced the dielectric loss from the ac relaxation in a crystals. Second, biaxial stretching constrained the amorphous phase in P(VDF-HFP) and thus the migrational loss from impurity ions was reduced. Third, biaxial stretching… Advisors/Committee Members: Baer, Eric (Committee Chair).

Subjects/Keywords: Plastics; Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yin, K. (2016). POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC APPLICATIONS. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841

Chicago Manual of Style (16^th Edition):

Yin, Kezhen. “POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC APPLICATIONS.” 2016. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841.

MLA Handbook (7^th Edition):

Yin, Kezhen. “POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC APPLICATIONS.” 2016. Web. 02 Mar 2021.

Vancouver:

Yin K. POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC APPLICATIONS. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2016. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841.

Council of Science Editors:

Yin K. POLYMER MULTILAYER FILMS FOR OPTICAL AND DIELECTRIC APPLICATIONS. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1469530841

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