You searched for publisher:("Case Western Reserve University School of Graduate Studies").
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1.
Stricker, Elizabeth Ann.
Cuprous Bromide Electrochemistry and its Application in a
Flow Battery.
Degree: PhD, Chemical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1546604124529032 
► Cuprous and cupric bromide electrochemistry and speciation was examined in electrolytes and concentrations of interest to an all-copper flow battery (CuFB) in a bromide ion…
(more)
▼ Cuprous and cupric bromide electrochemistry and
speciation was examined in electrolytes and concentrations of
interest to an all-copper flow battery (CuFB) in a bromide ion
supported electrolyte. The all-CuFB was also examined and it was
shown that an all-CuFB can operate at geometric current densities
of up to 300 mA cm-2 at a temperature of at least 50°C. In
addition, the battery was cycled for 50 cycles from 0 to 60% SOC
with plating capacities of 125 mAh cm-2 with a voltaic efficiency
of 64% at a temperature of 50°C. However, capacity fade (and thus
fading coulombic efficiency) was observed due to non-adherent
plating on the carbon electrode. Morphology and nucleation of
cuprous bromide was examined via current time transients and
qualitative plating experiments. Cuprous bromide electrodeposits
adhered to gold, silver, and platinum but did not adhere to
titanium or glassy carbon. This may due to a lattice mismatch
between the copper crystalline structure and the substrate
structure. It was determined that electronucleation of cuprous
bromide at 30°C between overpotentials of 10 and 150mV on glassy
carbon substrates most closely resembled progressive nucleation.
Utilizing in situ methods to study the electrochemical nucleation
and morphology of cuprous bromide led to the examination of high
aspect ratio small gap height cells with side by side electrodes
which are typically used for in situ ec-S/TEM. A Wagner number was
derived which allows one to determine whether uniform current
distribution is expected in the current ec-S/TEM cell design and
chemistry of interest.
Advisors/Committee Members: Savinell, Robert (Committee Chair).
Subjects/Keywords: Alternative Energy; Chemical Engineering; Chemistry; Engineering; Energy; Materials Science; Metallurgy; Nanotechnology; flow batteries; diffusion coefficient; diffusion; cupric; copper; halide; TEM; in situ; Wagner Number; morphology; in situ electrochemistry; microelectrochemistry; nanoelectrochemistry; self generating slurry; slurry; electron microscopy
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APA (6th Edition):
Stricker, E. A. (2019). Cuprous Bromide Electrochemistry and its Application in a
Flow Battery. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1546604124529032
Chicago Manual of Style (16th Edition):
Stricker, Elizabeth Ann. “Cuprous Bromide Electrochemistry and its Application in a
Flow Battery.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1546604124529032.
MLA Handbook (7th Edition):
Stricker, Elizabeth Ann. “Cuprous Bromide Electrochemistry and its Application in a
Flow Battery.” 2019. Web. 26 Feb 2020.
Vancouver:
Stricker EA. Cuprous Bromide Electrochemistry and its Application in a
Flow Battery. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1546604124529032.
Council of Science Editors:
Stricker EA. Cuprous Bromide Electrochemistry and its Application in a
Flow Battery. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1546604124529032
2.
Shkurti, Thomas E.
SIMULATION AND CONTROL ENHANCEMENTS FOR THE DA VINCI
SURGICAL ROBOT™.
Degree: MSs, EECS - Computer and Information Sciences, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1548248373927953
► The da Vinci Research Kit produced by Johns Hopkins University inserts a programmable control computer into the da Vinci Surgical Unit™’s previously closed-loop teleoperative control…
(more)
▼ The da Vinci Research Kit produced by Johns Hopkins
University inserts a programmable control computer into the da
Vinci Surgical Unit™’s previously closed-loop teleoperative control
system, allowing development of
semi-automated/supervisory-controlled robotic technology to
decrease operating time, surgeon fatigue, and risk of
complications. However, development is still limited by the cost
barriers to acquisition of hardware, low-level control interface
exposed by the research kit, and a lack of standardization forcing
different researchers to reinvent different versions of the same
basic functionality which are not inter-compatible. In order to
address these concerns, a research software package is presented
capable of running atop the DVRK. It includes realistic and
hardware-interoperable full-physics simulation of the robot, a
standardized control interface capable of executing complex
trajectories, a camera-calibration and vision system adapted to the
unique constraints of surgical endoscopic cameras, and a system for
managing hardware profiles for specific physical or simulated
robots.
Advisors/Committee Members: Newman, Wyatt (Committee Chair).
Subjects/Keywords: Computer Science; Robotics; Surgery; Robots; Surgical robotics; da Vinci Surgical Unit; Simulation; ROS; Robot Operating System
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APA (6th Edition):
Shkurti, T. E. (2019). SIMULATION AND CONTROL ENHANCEMENTS FOR THE DA VINCI
SURGICAL ROBOT™. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1548248373927953
Chicago Manual of Style (16th Edition):
Shkurti, Thomas E. “SIMULATION AND CONTROL ENHANCEMENTS FOR THE DA VINCI
SURGICAL ROBOT™.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1548248373927953.
MLA Handbook (7th Edition):
Shkurti, Thomas E. “SIMULATION AND CONTROL ENHANCEMENTS FOR THE DA VINCI
SURGICAL ROBOT™.” 2019. Web. 26 Feb 2020.
Vancouver:
Shkurti TE. SIMULATION AND CONTROL ENHANCEMENTS FOR THE DA VINCI
SURGICAL ROBOT™. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548248373927953.
Council of Science Editors:
Shkurti TE. SIMULATION AND CONTROL ENHANCEMENTS FOR THE DA VINCI
SURGICAL ROBOT™. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548248373927953
3.
Marusak, Charles.
MT1-MMP: TARGETING THE CENTER OF MELANOMA METASTASIS, GROWTH
AND TREATMENT RESISTANCE.
Degree: PhD, Biochemistry, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1548327646756039
► In the past decade advances in cancer research have dramatically improved melanoma prognosis. Metastatic melanoma, once considered untreatable, now takes advantage of a plethora of…
(more)
▼ In the past decade advances in cancer research have
dramatically improved melanoma prognosis. Metastatic melanoma, once
considered untreatable, now takes advantage of a plethora of
treatment strategies and lays at the vanguard of many experimental
techniques such as targeted therapy and immune therapy. Due to its
adaptability, melanoma has proven to be highly prone to developing
treatment resistance and no strategy has yet been developed to
combat late stage metastatic melanoma without a high risk of
resistance and reoccurrence.Membrane type 1 matrix
metalloproteinase (MT1-MMP) is a protease that is ubiquitously
expressed and necessary for development. As a collagenase, its
primary role is the digestion of collagen in the extracellular
matrix (ECM). More recently it has been shown to have roles through
direct cleavage or through its downstream effects in angiogenesis,
epithelial mesenchymal transition (EMT), invasion, migration,
survival and cell growth. This study aims to investigate MT1-MMP as
a viable target for inhibition in melanoma metastasis and growth.
It will also investigate melanomas resistance to BRAF targeted
therapy, identify a novel mechanism of resistance and present a new
strategy to counteract this resistance. It will be shown that
melanoma upregulates MT1-MMP expression in response to BRAF
inhibition and that this upregulation can cause an increase in
integrin-beta1 (ITGB1) signaling. It will also be shown that
knockdown of MT1-MMP mitigates this integrin BRAF inhibition
resistance and that MT1-MMP inhibition is a promising treatment
option for countering melanoma treatment resistance.
Advisors/Committee Members: Kao, Hung-Ying (Committee Chair), Bedogni, Barbara (Advisor).
Subjects/Keywords: Oncology; Medicine; Biochemistry; Biology; Biomedical Research; Cellular Biology; Chemistry; MMP14; MT1-MMP; Melanoma; Cancer; BRAF; Resistance; Treatment; Vemurafenib; Integrin; MMP2; Collagen; Targeted Therapy; FAK; ND322; Metastasis; Growth; Oncology; Medicine; Inhibitor
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APA (6th Edition):
Marusak, C. (2019). MT1-MMP: TARGETING THE CENTER OF MELANOMA METASTASIS, GROWTH
AND TREATMENT RESISTANCE. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1548327646756039
Chicago Manual of Style (16th Edition):
Marusak, Charles. “MT1-MMP: TARGETING THE CENTER OF MELANOMA METASTASIS, GROWTH
AND TREATMENT RESISTANCE.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1548327646756039.
MLA Handbook (7th Edition):
Marusak, Charles. “MT1-MMP: TARGETING THE CENTER OF MELANOMA METASTASIS, GROWTH
AND TREATMENT RESISTANCE.” 2019. Web. 26 Feb 2020.
Vancouver:
Marusak C. MT1-MMP: TARGETING THE CENTER OF MELANOMA METASTASIS, GROWTH
AND TREATMENT RESISTANCE. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548327646756039.
Council of Science Editors:
Marusak C. MT1-MMP: TARGETING THE CENTER OF MELANOMA METASTASIS, GROWTH
AND TREATMENT RESISTANCE. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548327646756039
4.
Li, Zhenpeng.
Information Programming by Scaling of Polymeric Layered
Systems.
Degree: PhD, Macromolecular Science and Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case154834158541737
► Chapter 1: The shape memory behavior of polyvinyl acetate (PVAc), both at macro- and micro-scale, is presented. PVAc films exhibited excellent efficiency in programming macro-scale…
(more)
▼ Chapter 1: The shape memory behavior of polyvinyl
acetate (PVAc), both at macro- and micro-scale, is presented. PVAc
films exhibited excellent efficiency in programming macro-scale
deformation. Cyclic tensile tests on PVAc films revealed the
importance of molecular weight in programming macro-scale
deformation in film. PVAc film with the highest molecular weight (~
228 kDa) exhibited maximum durability in programming macro-scale
deformation. This gives an important insight to the discovery of
new shape memory polymers since chain entanglements in high
molecular weight glassy polymers can impart shape memory behavior.
In addition, such shape memory behavior can be exploited to imprint
and tune micro-scale patterns on the film. Microprismatic patterns
were embossed and programmed on shape memorizing PVAc films. Two
different test methodologies were used to study the programmability
of patterns on PVAc films. Pattern programming was significantly
affected by the method used. In both cases, recovery time and
temperature were two important parameters to determine the
efficiency of programming. In addition, optical properties of PVAc
films could be switched between reflective and transparent by
programming patterns on the surface of the film.Chapter 2:
Micro-scale surface shape memory effects were investigated on
multilayer films that were produced with alternating layers of PVAc
and PU. Two different types of micro-scale patterns, including a
sharp microprismatic pattern and a smooth microlens pattern, were
embossed on the surface of the PVAc/PU multilayer films by a PDMS
replica mold using the soft lithography method. The microprismatic
pattern as a permanent surface structure on the intrinsically
transparent multilayer films renders the films opaque and the
microlens surface pattern endows the clear films with focusing
properties. The micro-structured surface is programmed by
compression and recovery to switch the corresponding optical
property of the film. Based on this switchable optical property,
the patterned PVAc/PU multilayer film can be employed as an
anti-counterfeiting feature in packaging. In this paper, the shape
memory effect of the multilayered film was found to be dependent on
the composition of the PVAc relative to the PU layers. In addition,
the shape memory effect of the layered PVAc/PU films was enhanced
compared to the PVAc control film. The recovery mechanism of the
shape memory films was interpreted using Burgers viscoelastic
model. The effects of the compression pressure, recovery
temperature and the geometry of the patterns on the micro-scale
shape memory behavior of the PVAc/PU multilayer films were also
investigated.Chapter 3: Nano-layered films of PVAc/PU systems were
fabricated by forced assembly coextrusion method. The bulk shape
memory properties of PVAc/PU systems were utilized to program
nanoscale patterns such as diffraction grating which exhibit
iridescence after patterning. A hot embossing process has been
utilized to imprint diffraction grating patterns as nano-scale
information onto…
Advisors/Committee Members: Baer, Eric (Advisor).
Subjects/Keywords: Polymers; Optics; Information Systems; polymeric multilayer films; shape memory films; programmable optics; information programming; multilayer dielectrics; capacitor films
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Li, Z. (2019). Information Programming by Scaling of Polymeric Layered
Systems. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case154834158541737
Chicago Manual of Style (16th Edition):
Li, Zhenpeng. “Information Programming by Scaling of Polymeric Layered
Systems.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case154834158541737.
MLA Handbook (7th Edition):
Li, Zhenpeng. “Information Programming by Scaling of Polymeric Layered
Systems.” 2019. Web. 26 Feb 2020.
Vancouver:
Li Z. Information Programming by Scaling of Polymeric Layered
Systems. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case154834158541737.
Council of Science Editors:
Li Z. Information Programming by Scaling of Polymeric Layered
Systems. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case154834158541737
5.
Huang, Siqi.
Kinematic Calibration for da Vinci Surgical Robot.
Degree: MSs, EECS - Electrical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1548418150820537
► This thesis focuses on kinematic calibration of a da Vinci surgical robot. Accurate calibration is key to advancing robotic surgery from teleoperation to supervised autonomy.…
(more)
▼ This thesis focuses on kinematic calibration of a da
Vinci surgical robot. Accurate calibration is key to advancing
robotic surgery from teleoperation to supervised autonomy. Means
and data are presented for arm calibration, resulting in
significantly improved accuracy. With a nominal kinematic model,
positioning error of a gripper wrist was found to be 3.5mm RMS.
After calibration, this error was reduced to 0.5mm RMS. In
addition, dual-arm operations require a coordinate-transform
calibration between the respective robot base frames. After
invoking the methods presented here, dual-arm motions were accurate
to within 0.7mm RMS error. Modeling, methods, data and analyses are
presented.
Advisors/Committee Members: Newman, Wyatt (Advisor).
Subjects/Keywords: Robotics; Electrical Engineering
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APA (6th Edition):
Huang, S. (2019). Kinematic Calibration for da Vinci Surgical Robot. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1548418150820537
Chicago Manual of Style (16th Edition):
Huang, Siqi. “Kinematic Calibration for da Vinci Surgical Robot.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1548418150820537.
MLA Handbook (7th Edition):
Huang, Siqi. “Kinematic Calibration for da Vinci Surgical Robot.” 2019. Web. 26 Feb 2020.
Vancouver:
Huang S. Kinematic Calibration for da Vinci Surgical Robot. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548418150820537.
Council of Science Editors:
Huang S. Kinematic Calibration for da Vinci Surgical Robot. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548418150820537
6.
Arora, Kavita S.
Insurance-Based Disparities in Provision of Postpartum
Sterilization and Long-Acting Reversible Contraception.
Degree: MSs, Clinical Research, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1548428371429909
► Many barriers to the most effective forms of postpartum contraception, sterilization and long-acting reversible contraception (LARC), exist. Our goal was to assess fulfillment of sterilization…
(more)
▼ Many barriers to the most effective forms of
postpartum contraception, sterilization and long-acting reversible
contraception (LARC), exist. Our goal was to assess fulfillment of
sterilization and LARC requests, timing of request completion, and
impact of non-fulfillment between those with Medicaid and private
insurance while accounting for the complex interplay between
insurance, clinical, and social factors. After analyzing a
retrospective cohort involving 8,654 women delivered at or beyond
20 weeks of gestation from January 1, 2012 through December 31,
2014 at our urban, tertiary-care teaching hospital, we concluded
that differences in fulfillment rates of postpartum sterilization
or LARC and time to sterilization or LARC between women with
Medicaid versus private insurance are not significant after
adjusting for relevant clinical and demographic factors. However,
adequacy of prenatal care remains an important factor to
fulfillment of postpartum sterilization and LARC, confirming the
importance of antenatal contraceptive counseling in reducing
disparities in contraceptive care.
Advisors/Committee Members: Mercer, Brian (Committee Chair).
Subjects/Keywords: Medicine; Obstetrics; Public Health; postpartum contraception; sterilization; long-acting reversible contraception; LARC; Medicaid; disparities; reproductive justice
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APA (6th Edition):
Arora, K. S. (2019). Insurance-Based Disparities in Provision of Postpartum
Sterilization and Long-Acting Reversible Contraception. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1548428371429909
Chicago Manual of Style (16th Edition):
Arora, Kavita S. “Insurance-Based Disparities in Provision of Postpartum
Sterilization and Long-Acting Reversible Contraception.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1548428371429909.
MLA Handbook (7th Edition):
Arora, Kavita S. “Insurance-Based Disparities in Provision of Postpartum
Sterilization and Long-Acting Reversible Contraception.” 2019. Web. 26 Feb 2020.
Vancouver:
Arora KS. Insurance-Based Disparities in Provision of Postpartum
Sterilization and Long-Acting Reversible Contraception. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548428371429909.
Council of Science Editors:
Arora KS. Insurance-Based Disparities in Provision of Postpartum
Sterilization and Long-Acting Reversible Contraception. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548428371429909
7.
Miller-Fellows, Sarah.
Making Medicine Amish.
Degree: PhD, Anthropology, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1548435040090677
► Amish communities have a unique distribution of genetic disorders due to founder effect and endogamy. The aim of this research was to examine how Amish…
(more)
▼ Amish communities have a unique distribution of
genetic disorders due to founder effect and endogamy. The aim of
this research was to examine how Amish communities have responded
to the presence of many rare inherited diseases. This research
specifically focused on the role of genetic medicine clinics in
Amish communities and how the presence of genetic diseases has
shaped Amish reproduction.Through a 2-year ethnographic study,
including 61 interviews, participant observation and text analysis,
I explored a variety of Amish responses to genetic disorders and
disability. I found that Amish communities largely accept those
with disabilities as part of the fabric of God’s creation, using
the emic category of special children to describe the particular
role those with intellectual disabilities play in their
communities. Amish communities have developed diverse social,
financial, educational, vocational and medical support systems for
those with disabilities. One such medical support is clinics for
inherited disorders and other complex medical needs. These clinics
hybridize biomedicine with Amish culture, emphasizing
relationships, low cost care, Amish aesthetics and aiming to treat
and manage disorders rather than prevent the births of those with
disorders. Amish people’s widespread acceptance of disability has
led women to use postnatal genetic testing through clinics rather
than prenatal genetic testing. I argue that clinics and the
practice of medicine within them provides a key example for how
biomedicine becomes hybrid through its encounter with other
cultures, forming in this
case, a distinctly Amish medicine. This
study expands previous anthropological literature by examining how
hybridity can emerge as a response to issues of cultural competence
and how cultural perspectives on disability can reshape medical
practice.
Advisors/Committee Members: Hildebrand, Vanessa (Committee Chair).
Subjects/Keywords: Cultural Anthropology; Amish, genetic medicine, medical anthropology,
biomedicine, Anabaptist, reproduction
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Manager
APA (6th Edition):
Miller-Fellows, S. (2019). Making Medicine Amish. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1548435040090677
Chicago Manual of Style (16th Edition):
Miller-Fellows, Sarah. “Making Medicine Amish.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1548435040090677.
MLA Handbook (7th Edition):
Miller-Fellows, Sarah. “Making Medicine Amish.” 2019. Web. 26 Feb 2020.
Vancouver:
Miller-Fellows S. Making Medicine Amish. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548435040090677.
Council of Science Editors:
Miller-Fellows S. Making Medicine Amish. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1548435040090677
8.
Brannum, Michelle T.
Functional Performance of Liquid Crystalline
Elastomers.
Degree: PhD, Macromolecular Science and Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1549025445138734
► Liquid crystal elastomers (LCEs) are promising actuating materials and potential enablers of robust flexible devices. Employing directed self-assembly methods, the inherent anisotropy of nematic liquid…
(more)
▼ Liquid crystal elastomers (LCEs) are promising
actuating materials and potential enablers of robust flexible
devices. Employing directed self-assembly methods, the inherent
anisotropy of nematic liquid crystals can be exploited with spatial
and hierarchical patterning of the director profiles. The
overarching theme of this work is the exploration and enablement of
the functional utility of liquid crystalline elastomers. The
research reported hereafter has focused on 1) light control enabled
by concurrent shape and color change in cholesteric liquid crystal
elastomers and 2) cyclic mechanical examination of the deformation
of liquid crystalline elastomers to load. Detailing a facile
approach to synthesizing cholesteric liquid crystalline elastomers
(CLCEs) that upon heating, exhibit thermochromism. The selective
reflection inherent to this phase is thermally tuned more than 200
nm in these solid films, across the visible spectrum. The optical
response is directly correlated to thermomechanical expansion of
the CLCE film thickness. Broadening of the bandwidth of the
selective reflection of the CLCEs is achieved with the
incorporation of photosensitive chiral dopants that introduce
heterogeneity in the pitch distribution. The mirror-like reflection
of this CLCE film is also thermochromic, shifting from the visible
to infrared. When combined with the mechanical deformation of
voxelated nematic LCE, the thermochromic response of the CLCE
produces solid-state elements with concurrent variation of specular
and diffuse reflectance. These results demonstrate distinctive
potential opportunities for liquid crystal elastomers to control
light enabling new application in textiles, optics, and
architecture. This work additionally characterizes the stimuli
response of nematic liquid crystalline elastomers (NLCEs) prepared
with the same synthetic method, exhibiting unprecedented mechanical
deformations of nearly 500% strain. Accordingly, this examination
seeks to elucidate the mechanical response of NLCEs prepared
through chain transfer reactions with diacrylate liquid crystal
monomers. The mechanical response to load is explored above and
below the yield point. The contribution of higher order patterns,
nascent to this material chemistry, are considered and partially
inform the distinctive mechanical response. This work assesses the
relevance of these materials as flexible substrates for electronic
devices and other implementations that could exploit the nonlinear
mechanical deformation.
Advisors/Committee Members: Wnek, Gary (Committee Chair).
Subjects/Keywords: Polymers
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Manager
APA (6th Edition):
Brannum, M. T. (2019). Functional Performance of Liquid Crystalline
Elastomers. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1549025445138734
Chicago Manual of Style (16th Edition):
Brannum, Michelle T. “Functional Performance of Liquid Crystalline
Elastomers.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1549025445138734.
MLA Handbook (7th Edition):
Brannum, Michelle T. “Functional Performance of Liquid Crystalline
Elastomers.” 2019. Web. 26 Feb 2020.
Vancouver:
Brannum MT. Functional Performance of Liquid Crystalline
Elastomers. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1549025445138734.
Council of Science Editors:
Brannum MT. Functional Performance of Liquid Crystalline
Elastomers. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1549025445138734
9.
Guo, Yin.
Predictive On-Line Operational Management of V2G
Participating in the Frequency Regulation for an Office
Garage.
Degree: PhD, EECS - Electrical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1551708169877708
► The development of vehicle-to-grid (V2G) technology offers potential benefits to both electric vehicle owners and grid operators by providing frequency regulation service. Such benefits could…
(more)
▼ The development of vehicle-to-grid (V2G) technology
offers potential benefits to both electric vehicle owners and grid
operators by providing frequency regulation service. Such benefits
could be significant, because the vehicles are usually idle for
most of the time in a day. However, it is difficult to maximize
such benefits via cost-optimized on-line scheduling based on
predictive real-time prices. First and foremost, this is due to the
uncertainty of actual prices and the variability of prediction
obtained at different time points. In addition, the energy needed
for providing regulation service is unknown when making the
schedule. Second, in order to participate in the frequency
regulation market, an aggregator is usually needed as an interface
between vehicles and grid operators. However, the optimal bidding
capacity for the aggregator may conflict with the optimal schedule
of individual vehicles. Last, the vehicle’s ability to gain maximum
profit is limited when the battery’s state of charge (SOC) is close
to its extreme values.To overcome those limitations, this thesis
proposes a new tool for the operational management of V2G frequency
regulation. The proposed tool integrates: 1) a cost-optimized
predictive on-line scheduling model for individual vehicles, 2) a
cost-optimized frequency regulation capacity bidding model for an
aggregator, and 3) a real-time synergetic dispatch model. The
scheduling model for individual vehicles is formulated as a
three-stage stochastic linear program which considers the
uncertainties in 1) energy and frequency regulation prices, and 2)
hourly average frequency regulation signal. The advantages of the
proposed tool are: 1) the proposed tool properly integrates
scheduling, capacity bidding and real-time dispatch; 2) the
proposed scheduling models for individual EVs and the aggregator
are on-line scheduling models which take the advantage of the most
recent predicted electricity prices; 3) the proposed scheduling
models for individual EVs and the aggregator forms a
semi-centralized scheduling schema, which overcomes the
disadvantages of centralized and decentralized models; 4) the
consideration of the stochastic property of the parameters helps
reduce the risk associate with the uncertainty, and also increase
the potential profit; 5) the proposed three-stage stochastic linear
programming model for the scheduling of individual vehicles greatly
reduces the computational effort required by a conventional
multi-stage model; 6) the proposed heuristic solution method with
the utilization of GPU for parallel computation can significantly
further increase the computational efficiency; 7) the proposed
real-time synergetic dispatch can properly maintain the battery’s
SOC within a designated range, which insures that the battery
energy constraint can be eliminated from the scheduling model, and
helps reduce the complexity of the scheduling model.The proposed
tool is evaluated via a simulation of an arbitrary aggregator for
an office garage which consists of 100 EVs. The simulation result…
Advisors/Committee Members: Prica, Marija (Committee Chair).
Subjects/Keywords: Electrical Engineering; Energy
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MLA ·
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Manager
APA (6th Edition):
Guo, Y. (2019). Predictive On-Line Operational Management of V2G
Participating in the Frequency Regulation for an Office
Garage. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1551708169877708
Chicago Manual of Style (16th Edition):
Guo, Yin. “Predictive On-Line Operational Management of V2G
Participating in the Frequency Regulation for an Office
Garage.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1551708169877708.
MLA Handbook (7th Edition):
Guo, Yin. “Predictive On-Line Operational Management of V2G
Participating in the Frequency Regulation for an Office
Garage.” 2019. Web. 26 Feb 2020.
Vancouver:
Guo Y. Predictive On-Line Operational Management of V2G
Participating in the Frequency Regulation for an Office
Garage. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1551708169877708.
Council of Science Editors:
Guo Y. Predictive On-Line Operational Management of V2G
Participating in the Frequency Regulation for an Office
Garage. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1551708169877708
10.
Jones, Jaes Christian.
The Electrophysiological Effect of Low-Frequency Sensory
Stimulation in Medically Refractory Epilepsy.
Degree: MSs, Biomedical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194
► Low-frequency audio-visual stimulation has been shown to effectively reduce seizures in two animal models of medically refractory epilepsy. As such, low-frequency sensory stimulation (LFSS) may…
(more)
▼ Low-frequency audio-visual stimulation has been shown
to effectively reduce seizures in two animal models of medically
refractory epilepsy. As such, low-frequency sensory stimulation
(LFSS) may result in decreased epileptogenic activity in patients
with MRE.A clinical trial was used to study the effect of LFSS in 6
patients with MRE. Each patient received both LFSS and control
stimulation from a non-invasive audio-visual device for 20 minutes.
Spike rates were then compared between stimulation, pre-stim, and
post-stim periods. Globally, LFSS increased spike rates compared to
baseline (116.126% increase, p = 0.005). For analysis of spikes
originating from leads within the hypothesized epileptogenic zone,
LFSS decreased spike rates compared to baseline (-41.567%, p <
0.001) and controls stimulation did not (-28.365%, p =
0.089).Therefore, LFSS decreases spike frequency in the EZ,
indicating likely therapeutic effects with longer stimulation
times, a study of which is needed in order to draw definitive
conclusions.
Advisors/Committee Members: Durand, Dominique (Advisor), Nair, Dileep (Advisor), Gonzalez-Martinez, Jorge (Committee Co-Chair).
Subjects/Keywords: Biomedical Engineering; Biomedical Research; Engineering; Health Care; Medicine; Neurology; Neurosciences; Surgery; Epilepsy; Neuromodulation; Non-Invasive; Stereoelectroencephalography; Low-Frequency Stimulation; LFS; Low-Frequency Sensory Stimulation; LFSS; Medically Refractory Epilepsy; MRE
Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jones, J. C. (2019). The Electrophysiological Effect of Low-Frequency Sensory
Stimulation in Medically Refractory Epilepsy. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194
Chicago Manual of Style (16th Edition):
Jones, Jaes Christian. “The Electrophysiological Effect of Low-Frequency Sensory
Stimulation in Medically Refractory Epilepsy.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194.
MLA Handbook (7th Edition):
Jones, Jaes Christian. “The Electrophysiological Effect of Low-Frequency Sensory
Stimulation in Medically Refractory Epilepsy.” 2019. Web. 26 Feb 2020.
Vancouver:
Jones JC. The Electrophysiological Effect of Low-Frequency Sensory
Stimulation in Medically Refractory Epilepsy. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194.
Council of Science Editors:
Jones JC. The Electrophysiological Effect of Low-Frequency Sensory
Stimulation in Medically Refractory Epilepsy. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1551894047504194
11.
Liu, Haitao.
NEUTROPHIL ELASTASE CONTRIBUTES TO THE EARLY DIABETIC
RETINOPATHY.
Degree: PhD, Biology, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1552485945496003
► It is well documented that oxidative stress and inflammation are involved in the degeneration of retinal capillaries in diabetes, a hall mark of diabetic retinopathy…
(more)
▼ It is well documented that oxidative stress and
inflammation are involved in the degeneration of retinal
capillaries in diabetes, a hall mark of diabetic retinopathy (DR),
and it has been shown that leukocytes, especially neutrophils, play
a causal role in retinal abnormalities including diabetic-induced
degeneration of retinal capillaries observed in DR. However, the
mechanism by which neutrophil cause such degeneration is unknown.
Neutrophil serine proteases (NSPs), granules-associated enzymes
secreted by neutrophils have been reported to participate in a
variety of inflammatory diseases such as chronic obstructive
pulmonary disease. Then, in the present work we investigated the
potential involvement of NSPs in the development of capillary
degeneration associated with DR. Neutrophil elastase (NE), one of
the 3 NSPs, was selectively inhibited in diabetic mice using (i)
sivelestat or (ii) in mice lacking NE, and (iii) where general
protease activity was inhibited by over expression of protease
inhibitor alpha-1 antitrypsin. These groups of mice were made
diabetic and assessed for diabetes-induced retinal superoxide
generation, inflammation, leukostasis, and retinal capillary
degeneration and retinal vascular leakage. In 2-month diabetic
mice, selective inhibition of NE or deletion of NE inhibited
diabetes-induced retinal superoxide production, inflammation and
leukocyte-mediated cytotoxicity to retinal endothelial cells. In
8-month diabetic mice, genetic deletion of NE significantly
inhibited diabetes-induced leakage and degeneration retinal
capillaries. In vitro
studies show that NE induced increased
permeability of retinal endothelial cells was inhibited by
protease-activated receptor (PAR)-2 inhibitor. Taking together,
these results suggest that NE may contribute to the development of
diabetic retinopathy, and thus blocking NE activity could be a
novel therapy to prevent DR.
Advisors/Committee Members: Kern, Timothy (Advisor), Diamond, Sarah (Committee Chair).
Subjects/Keywords: Biomedical Research; diabetic retinopathy, neutrophil elastase
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Liu, H. (2019). NEUTROPHIL ELASTASE CONTRIBUTES TO THE EARLY DIABETIC
RETINOPATHY. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1552485945496003
Chicago Manual of Style (16th Edition):
Liu, Haitao. “NEUTROPHIL ELASTASE CONTRIBUTES TO THE EARLY DIABETIC
RETINOPATHY.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1552485945496003.
MLA Handbook (7th Edition):
Liu, Haitao. “NEUTROPHIL ELASTASE CONTRIBUTES TO THE EARLY DIABETIC
RETINOPATHY.” 2019. Web. 26 Feb 2020.
Vancouver:
Liu H. NEUTROPHIL ELASTASE CONTRIBUTES TO THE EARLY DIABETIC
RETINOPATHY. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1552485945496003.
Council of Science Editors:
Liu H. NEUTROPHIL ELASTASE CONTRIBUTES TO THE EARLY DIABETIC
RETINOPATHY. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1552485945496003
12.
McMaster, Michael S.
Optoelectronic Applications For Bio-Based Materials.
Degree: PhD, Physics, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case155257775382127
► Recently, bio-based materials are increasingly considered to replace traditional components for opto-electronic applications as part of a massive effort to reduce our carbon footprint. This…
(more)
▼ Recently, bio-based materials are increasingly
considered to replace traditional components for opto-electronic
applications as part of a massive effort to reduce our carbon
footprint. This thesis describes opto-electronic applications
developed for two classes of bio-based materials, a bio-based epoxy
and bacterial cellulose mats, and it also describes the dielectric
investigation of thermoplastic polyurethane composites with
improved properties for sensing applications. Specifically, a
series of bio-based epoxy resins with similar chemical structure to
petroleum derived diglycidyl ether of Bisphenol A (DGEBA), are
considered as a replacement for energy capacitive storage
applications. Also applications were developed for bacterial
cellulose, a bio-based 3D matrix of cellulose fibers produced by a
bacterial culture. Ultra-thin (<1 μm thick) bacterial cellulose
mats were produced and shown to have antireflective properties for
silicon wafers suggesting antireflective applications for silicon
based solar cells. Bacterial cellulose has an interesting and
complex geometry consisting of entwined, crystalline, cellulose
nanofibers. Also, electro-optical switchable window devices were
fabricated with bacterial cellulose mats filled with liquid
crystals as the electro-optical component. Additionally, the
bicontinuous network of nanpores is an interesting environment for
studying liquid crystal physics. Dynamic light scattering and
broadband dielectric spectroscopy were employed to study the liquid
crystal relaxations for the composites give insight into the
fundamental liquid crystal physics of the system. Lastly,
thermoplastic polyurethane composites using different ratios of
carbon nanostructure and graphene nanoplatelet inorganic fillers
were investigated for mechanical and dielectric properties.
Composites with 0.5 weight percent of filler were considered for
temperature sensing applications. Additionally, composites with 2.0
weight percent of filler we shown to have an extremely high
capacitance-pressure sensitivity for a stress range of 0.1~1.3 MPa,
implying potential applications in prosthetics and wearable
electronics. In conclusion, we propose novel applications for
advanced bio-based and composite materials for reducing carbon
consumption, and introduce motifs to futher improve future
devices.
Advisors/Committee Members: Singer, Kenneth (Advisor).
Subjects/Keywords: Physics; Antireflection AR, Bio-Based, Liquid Crystal LC,
Thermoplastic Polyurethane TPU, Epoxy
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APA ·
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MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McMaster, M. S. (2019). Optoelectronic Applications For Bio-Based Materials. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case155257775382127
Chicago Manual of Style (16th Edition):
McMaster, Michael S. “Optoelectronic Applications For Bio-Based Materials.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case155257775382127.
MLA Handbook (7th Edition):
McMaster, Michael S. “Optoelectronic Applications For Bio-Based Materials.” 2019. Web. 26 Feb 2020.
Vancouver:
McMaster MS. Optoelectronic Applications For Bio-Based Materials. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case155257775382127.
Council of Science Editors:
McMaster MS. Optoelectronic Applications For Bio-Based Materials. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case155257775382127
13.
Cheng, Zhihan.
MECHANICALLY STRONG/ LOW FLAMMABILITY POLY (VINYL ALCOHOL)
AEROGELS.
Degree: MSs (Engineering), Macromolecular Science and Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case155266644473611
► Poly (vinyl alcohol) (PVA), tannic acid (TA) and sodium hydroxide (NaOH) were used to prepare low flammability, mechanically strong aerogels via an environmentally friendly freeze…
(more)
▼ Poly (vinyl alcohol) (PVA), tannic acid (TA) and
sodium hydroxide (NaOH) were used to prepare low flammability,
mechanically strong aerogels via an environmentally friendly freeze
drying method. Because of the strong interaction between TA and PVA
through hydrogen bonds, PVA/TA/NaOH aerogels exhibited compressive
moduli as high as 12.7 MPa, 20 times of the control PVA aerogel.
The microstructure of the aerogels in this study showed that the
addition of NaOH disrupt the typical “card of house” aerogel
structure while the samples with TA showed a stereoscopic uniform
structure. The thermal stabilities of aerogels were tested by
thermogravimetric analysis, showing both a decrease on the onset of
decomposition temperature, and a reduction in decomposition rate
after initial char formation. The peak heat release rate and total
heat release, as measured by cone calorimetry, dropped by 69% and
54% respectively after adding TA and NaOH. The mechanism of NaOH
effect which could catalyze char formation is also
discussed.
Advisors/Committee Members: Schiraldi, David (Advisor), Schiraldi, David (Committee Chair).
Subjects/Keywords: Polymers; Polymer Chemistry; Materials Science; PVA, Aerogel, Tannic acid, sodium hydroxide, mechanically
strong, flammability, freeze drying, sustainable
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Manager
APA (6th Edition):
Cheng, Z. (2019). MECHANICALLY STRONG/ LOW FLAMMABILITY POLY (VINYL ALCOHOL)
AEROGELS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case155266644473611
Chicago Manual of Style (16th Edition):
Cheng, Zhihan. “MECHANICALLY STRONG/ LOW FLAMMABILITY POLY (VINYL ALCOHOL)
AEROGELS.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case155266644473611.
MLA Handbook (7th Edition):
Cheng, Zhihan. “MECHANICALLY STRONG/ LOW FLAMMABILITY POLY (VINYL ALCOHOL)
AEROGELS.” 2019. Web. 26 Feb 2020.
Vancouver:
Cheng Z. MECHANICALLY STRONG/ LOW FLAMMABILITY POLY (VINYL ALCOHOL)
AEROGELS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case155266644473611.
Council of Science Editors:
Cheng Z. MECHANICALLY STRONG/ LOW FLAMMABILITY POLY (VINYL ALCOHOL)
AEROGELS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case155266644473611
14.
Pollack, Brian.
Personal Data Attic as Alternative to Public Cloud.
Degree: MSs, EECS - Computer and Information Sciences, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1552951966578715
► In this thesis we explore an alternative for a user who does not wish to relinquish his or her data to a cloud service provider.…
(more)
▼ In this thesis we explore an alternative for a user
who does not wish to relinquish his or her data to a cloud service
provider. We propose the data attic: a storage server that can be
installed on a user's premises. A data attic user may grant access
to institutions such as medical providers whose software could
automatically save patients' information to the patient's own data
attic, allowing the patient to share medical information among all
healthcare facilities he or she accesses and to assemble the
medical records from all those providers in one place, under the
patient's control. We provide a prototype data attic server, data
attic client, and a C library used to recompile existing C
programs, retrofitting them to store data on a data attic. We run
performance tests that show the data attic is a viable approach
that does not present insurmountable implementation or performance
challenges.
Advisors/Committee Members: Rabinovich, Michael (Advisor).
Subjects/Keywords: Computer Science
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APA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pollack, B. (2019). Personal Data Attic as Alternative to Public Cloud. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1552951966578715
Chicago Manual of Style (16th Edition):
Pollack, Brian. “Personal Data Attic as Alternative to Public Cloud.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1552951966578715.
MLA Handbook (7th Edition):
Pollack, Brian. “Personal Data Attic as Alternative to Public Cloud.” 2019. Web. 26 Feb 2020.
Vancouver:
Pollack B. Personal Data Attic as Alternative to Public Cloud. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1552951966578715.
Council of Science Editors:
Pollack B. Personal Data Attic as Alternative to Public Cloud. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1552951966578715
15.
Karas, Shane Michael.
Construing the News: A Cognitive Grammar Approach to Online
Headlines.
Degree: MA, Cognitive Linguistics, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554305475795068
► The emergence of online news has significantly influenced news production and consumption. Notably, key characteristics of online news, including immediacy and interactivity, have contributed to…
(more)
▼ The emergence of online news has significantly
influenced news production and consumption. Notably, key
characteristics of online news, including immediacy and
interactivity, have contributed to a new degree of fluidity;
articles are now published, edited, shared, and consumed
continuously. This poses considerable challenges as many articles
are published while stories are still unfolding and undergo
significant changes after publication. Editors have generally
resisted calls to annotate these edits, suggesting that they view
them as minor. Conversely, Cognitive Grammar holds that small
changes to construal – the way a situation is presented – influence
meaning. The present thesis explores evolving construals of online
news headlines. Through analysis of 28 examples, this thesis argues
that even minor edits may alter meaning in significant ways. It
also serves as a proof of concept for a novel way of collecting
attested examples of evolving construals, demonstrating how the
internet may make new types of data obtainable.
Advisors/Committee Members: Oakley, Todd (Committee Chair).
Subjects/Keywords: Communication; Journalism; Linguistics; Mass Media; Mass Communications; Sociolinguistics; profiling; attentional windowing; journalism; online news; cognitive grammar
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Karas, S. M. (2019). Construing the News: A Cognitive Grammar Approach to Online
Headlines. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554305475795068
Chicago Manual of Style (16th Edition):
Karas, Shane Michael. “Construing the News: A Cognitive Grammar Approach to Online
Headlines.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554305475795068.
MLA Handbook (7th Edition):
Karas, Shane Michael. “Construing the News: A Cognitive Grammar Approach to Online
Headlines.” 2019. Web. 26 Feb 2020.
Vancouver:
Karas SM. Construing the News: A Cognitive Grammar Approach to Online
Headlines. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554305475795068.
Council of Science Editors:
Karas SM. Construing the News: A Cognitive Grammar Approach to Online
Headlines. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554305475795068
16.
Cheng, Yu-Shiuan.
POLYUNSATURATED LIPID OXIDATION PRODUCTS AND THEIR
BIOLOGICAL ACTIVITIES: SYNTHESIS, GENERATION, EFFECTS AND
PROTECTION.
Degree: PhD, Chemistry, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1553850446781064
► Oxidized lipids are generated from polyunsaturated fatty acid-containing phospholipids under conditions of oxidative stress, and are increasingly believed to be associated with age-related diseases. Oxidation…
(more)
▼ Oxidized lipids are generated from polyunsaturated
fatty acid-containing phospholipids under conditions of oxidative
stress, and are increasingly believed to be associated with
age-related diseases. Oxidation of arachidonic acid (AA)-containing
phospholipids generates levuglandins that possess reactive
γ-ketoaldehyde functional arrays that avidly react with the primary
amino groups in biomolecules, which are then transformed into
pyrrole derivatives. These protein modifications can interfere with
their functions. Recently, an oxidized form of levuglandin
(LG)D
2 (ox-LGD
2) was
isolated from the red alga <i>Gracilaria edulis</i>. It
is presumably a detoxification metabolite of levuglandins. In order
to confirm its structure, a concise total synthesis, implementing
an efficient three-component coupling to assemble the main body,
was developed in this study. Other than
ox-LGD
2, its regioisomer
ox-LGE
2 and unexpected rearranged isomer
Δ
6-ox-LGD
2 were also
successfully synthesized and well characterized.Oxidation of
phospholipids containing docosahexaenoic acid (DHA) generates
truncation products, 4-hydroxy-7-oxo-hept-5-enoic acid (HOHA)
phospholipids (PLs), which undergo spontaneous deacylation forming
a biologically active compound, HOHA-lactone. HOHA-lactone is a
precursor of ω-carboxyethylpyrrole (CEP) that has significant
pathological and physiological relevance to age-related macular
degeneration (AMD). It can also be metabolized by RPE cells through
conjugation with glutathione GSH, forming a Michael adduct
HOHA-lactone GSH that is reduced to an alcohol
4,7-dihydroxyhept-5-enoic acid (DHHA)-lactone GSH and transported
out of the cells. DHHA-lactone GSH is considered as a relatively
stable metabolite of HOHA-lactone. It can be used for monitoring
the generation of HOHA-lactone. Two in vitro models were utilized
to study light damage in retina. First, in a bovine retina tissue
model, elevated levels of HOHA-lactone GSH and DHHA-lactone GSH
were found in the bovine retina extract exposed to UVA or white
light. Second, in a RPE cell model, elevated levels of DHHA-lactone
GSH were generated in DHA-rich cells upon light exposure of and
even higher levels were generated in DHA-rich/A2E-laden cells. The
increasing levels of DHHA-lactone GSH in RPE cells, which indicates
the increase of HOHA-lactone, were strongly correlated with a
decrease of cell viability, cellular GSH levels, mitochondrial
membrane potential, lysosome integrity, the increase of CEP levels
and cellular senescence.HOHA-lactone that had previously found to
induce angiogenesis, apoptosis and activate the complement pathway,
was now also found to cause mitochondrial dysfunction by impairing
mitochondrial respiratory chain complexes – also called the
oxidative phosphorylation system (OXPHOS) or the electron transport
chain (ETC) – in this study. Damage of mitochondrial respiratory
chain complexes leads to generation of mitochondrial reactive
oxygen species (mtROS) and depletion of cell energy…
Advisors/Committee Members: Salomon, Robert (Advisor), Zagorski, Michael (Committee Chair).
Subjects/Keywords: Chemistry
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Manager
APA (6th Edition):
Cheng, Y. (2019). POLYUNSATURATED LIPID OXIDATION PRODUCTS AND THEIR
BIOLOGICAL ACTIVITIES: SYNTHESIS, GENERATION, EFFECTS AND
PROTECTION. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1553850446781064
Chicago Manual of Style (16th Edition):
Cheng, Yu-Shiuan. “POLYUNSATURATED LIPID OXIDATION PRODUCTS AND THEIR
BIOLOGICAL ACTIVITIES: SYNTHESIS, GENERATION, EFFECTS AND
PROTECTION.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1553850446781064.
MLA Handbook (7th Edition):
Cheng, Yu-Shiuan. “POLYUNSATURATED LIPID OXIDATION PRODUCTS AND THEIR
BIOLOGICAL ACTIVITIES: SYNTHESIS, GENERATION, EFFECTS AND
PROTECTION.” 2019. Web. 26 Feb 2020.
Vancouver:
Cheng Y. POLYUNSATURATED LIPID OXIDATION PRODUCTS AND THEIR
BIOLOGICAL ACTIVITIES: SYNTHESIS, GENERATION, EFFECTS AND
PROTECTION. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1553850446781064.
Council of Science Editors:
Cheng Y. POLYUNSATURATED LIPID OXIDATION PRODUCTS AND THEIR
BIOLOGICAL ACTIVITIES: SYNTHESIS, GENERATION, EFFECTS AND
PROTECTION. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1553850446781064
17.
Roman, Alex.
Open-Source Test-Bench Design for Applications in
AutonomousUltrasound Imaging.
Degree: MSs (Engineering), EECS - Electrical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1553879717367924
► Over the last few years, there has been an increased interest in the use of ultrasoundin a variety of research applications. Due to this increased…
(more)
▼ Over the last few years, there has been an increased
interest in the use of ultrasoundin a variety of research
applications. Due to this increased interest, there is a needfor
the development of customized transmission, reception, and
processing algorithms,along with low-cost programmable ultrasound
imaging devices that would be more desirablefor the variety of
research applications. This thesis describes a programmable
64-channel system-on-chip (SoC)-based test bench that will be
utilized for future researchand development on autonomous wearable
and implantable medical ultrasound imagingapplications. The current
setup consists of a custom transmitter, a custom
high-voltage(HV)multiplexer, an off-the-shelf receiver, and
embedded software on a Systemon Chip. This prototype results in a
modular design that can be easily updated withimproved hardware and
software for different applications. This thesis describes
thecurrent system hardware and software design along with the
initial imaging results ontissue phantoms.
Advisors/Committee Members: Mandal, Soumyajit (Advisor).
Subjects/Keywords: Electrical Engineering; ultrasound; open-source; test-bench
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MLA ·
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Manager
APA (6th Edition):
Roman, A. (2019). Open-Source Test-Bench Design for Applications in
AutonomousUltrasound Imaging. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1553879717367924
Chicago Manual of Style (16th Edition):
Roman, Alex. “Open-Source Test-Bench Design for Applications in
AutonomousUltrasound Imaging.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1553879717367924.
MLA Handbook (7th Edition):
Roman, Alex. “Open-Source Test-Bench Design for Applications in
AutonomousUltrasound Imaging.” 2019. Web. 26 Feb 2020.
Vancouver:
Roman A. Open-Source Test-Bench Design for Applications in
AutonomousUltrasound Imaging. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1553879717367924.
Council of Science Editors:
Roman A. Open-Source Test-Bench Design for Applications in
AutonomousUltrasound Imaging. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1553879717367924
18.
Nagaraj, Varun.
Emergent Learning in Digital Product Teams.
Degree: PhD, Management, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1553980113426569
► As digital technologies transform the economy, more teams than ever before are developing digital products in environments that are dynamic and unfamiliar to them. A…
(more)
▼ As digital technologies transform the economy, more
teams than ever before are developing digital products in
environments that are dynamic and unfamiliar to them. A digital
product team typically does not a priori possess all the knowledge
required to appropriately interpret and respond to its environment.
Therefore, the team’s ability to learn fast and continuously—to
acquire as-required new knowledge and change cognition and action
as a result—becomes critical to its success. Relative to
traditional new product development (NPD), digital NPD is
idiosyncratic, and consequently, team learning in digital NPD is
different from team learning in traditional NPD.This research
inquiry aims to develop a preliminary understanding of the emerging
and poorly understood socio-technical phenomenon of team learning
in digital NPD. The inquiry frames learning as a
technology-constituted process and uses an unorthodox mixed methods
research design—consisting of concurrent qualitative and
quantitative
studies that partially inform a third design science
study—in order to explore three key facets of the multi-level
phenomenon. Each study examines a different facet, is situated at a
different level, and characterizes a different learning process
mechanism. Meta-inferences are then inductively and abductively
derived to provide a more generalized understanding of the
phenomenon. Study 1 uses constructivist grounded theory development
to discover an individual-level process mechanism called
senseshaping used by the NPD team’s product manager to craft a team
response to a trigger event. Study 2 uses structural equation
modeling to characterize the effects of the popular team-level
design thinking mechanism used by the NPD team to learn and develop
new products. Study 3 uses design science research methodology to
develop and evaluate a technology-constituted team-level process
mechanism called the Product-Assisted-Learning (PAL) Loop that
enables learning from product feedback. Integration yields the
following meta-inferences: (1) concurrently deployed process
mechanisms are generally complementary but may cause tensions that
should be constructively channeled; and (2) learning in digital
product teams is emergent (arising in unexpected ways during
performance and calling for prompt action), and is enabled by
ambidextrous and improvised learning capabilities and the
thoughtful use of software tools in the learning process.The
theorizing around senseshaping and emergent learning contributes to
sensemaking and team learning scholarship. The research addresses
the gap in empirical
studies on the effects of design thinking and
contributes to the lean-agile literature by unpacking the
technology-constituted PAL Loop. In aggregate, the research offers
pragmatic prescriptions regarding practices and tools that product
teams and leaders can implement to increase their proficiency in
digital product development.
Advisors/Committee Members: Lyytinen, Kalle (Committee Chair).
Subjects/Keywords: Business Administration; Design; Information Systems; Management; Marketing; Organizational Behavior; Social Structure; Systems Design; Technology; digital transformation; digital new product development; team learning; fast learning; sensemaking; fuzzy front end; design thinking; lean startup; agile development; senseshaping; emergent learning; learning process mechanism; logic of action
Record Details
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APA ·
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MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nagaraj, V. (2019). Emergent Learning in Digital Product Teams. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1553980113426569
Chicago Manual of Style (16th Edition):
Nagaraj, Varun. “Emergent Learning in Digital Product Teams.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1553980113426569.
MLA Handbook (7th Edition):
Nagaraj, Varun. “Emergent Learning in Digital Product Teams.” 2019. Web. 26 Feb 2020.
Vancouver:
Nagaraj V. Emergent Learning in Digital Product Teams. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1553980113426569.
Council of Science Editors:
Nagaraj V. Emergent Learning in Digital Product Teams. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1553980113426569
19.
sang, zhen.
CONDUCTIVE ELASTOMER NANOCOMPOSITES FOR STRAIN SENSORS
APPLICATIONS.
Degree: MSs, Macromolecular Science and Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554126739899435
► Conductive elastomer composites (CECs), consisting of electrically conductive nanofillers and elastomers, have shown significant potential for wearable electronics due to their good combination of conductivity…
(more)
▼ Conductive elastomer composites (CECs), consisting of
electrically conductive nanofillers and elastomers, have shown
significant potential for wearable electronics due to their good
combination of conductivity and stretchability. However, it is
challenging to simultaneously achieve low percolation threshold,
wide strain sensing range and high strain sensitivity. In this
study, we introduced a new type of branched carbon nanostructures,
known as carbon nanostructure (CNS) and melt compounding them with
thermoplastic polyurethane which has excellent elasticity and good
affinity with carbon fillers. The melt-mixed TPU/CNS composites
demonstrate outstanding electrical conductivity and low percolation
threshold (Φc) by comparison with that of TPU/straight carbon
nanotube (CNT) systems.By taking advantage of CNS, we further
developed a facile and environmental friendly strategy towards
achieving highly stretchable strain sensors. Inspired by the
brick-wall structure, a robust segregated conductive network of CNS
is formed at TPU powders interface, which contributes directly to
the extremely low Φc, wider strain sensing range and better
reproducibility compared with melt compounded composites. This
strategy advances the understanding of the effects of
polymer-filler interface on the properties enhancements for polymer
composites.Conductive elastomer composites (CECs), consisting of
electrically conductive nanofillers and elastomers, have shown
significant potential for wearable electronics due to their good
combination of conductivity and stretchability. However, it is
challenging to simultaneously achieve low percolation threshold,
wide strain sensing range and high strain sensitivity. In this
study, we introduced a new type of branched carbon nanostructures,
known as carbon nanostructure (CNS) and melt compounding them with
thermoplastic polyurethane which has excellent elasticity and good
affinity with carbon fillers. The melt-mixed TPU/CNS composites
demonstrate outstanding electrical conductivity and low percolation
threshold (Φc) by comparison with that of TPU/straight carbon
nanotube (CNT) systems.By taking advantage of CNS, we further
developed a facile and environmental friendly strategy towards
achieving highly stretchable strain sensors. Inspired by the
brick-wall structure, a robust segregated conductive network of CNS
is formed at TPU powders interface, which contributes directly to
the extremely low Φc, wider strain sensing range and better
reproducibility compared with melt compounded composites. This
strategy advances the understanding of the effects of
polymer-filler interface on the properties enhancements for polymer
composites.
Advisors/Committee Members: Manas-Zloczower, Ica (Committee Chair).
Subjects/Keywords: Design; Materials Science
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
sang, z. (2019). CONDUCTIVE ELASTOMER NANOCOMPOSITES FOR STRAIN SENSORS
APPLICATIONS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554126739899435
Chicago Manual of Style (16th Edition):
sang, zhen. “CONDUCTIVE ELASTOMER NANOCOMPOSITES FOR STRAIN SENSORS
APPLICATIONS.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554126739899435.
MLA Handbook (7th Edition):
sang, zhen. “CONDUCTIVE ELASTOMER NANOCOMPOSITES FOR STRAIN SENSORS
APPLICATIONS.” 2019. Web. 26 Feb 2020.
Vancouver:
sang z. CONDUCTIVE ELASTOMER NANOCOMPOSITES FOR STRAIN SENSORS
APPLICATIONS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554126739899435.
Council of Science Editors:
sang z. CONDUCTIVE ELASTOMER NANOCOMPOSITES FOR STRAIN SENSORS
APPLICATIONS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554126739899435
20.
Chen, Taiyu.
The Mobile Software System Design to Provide Self-management
Healthful Intervention.
Degree: MSs (Engineering), EECS - Computer Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554220151544945
► The concept of self-management has been mentioned frequently in the medical field due to the stronger awareness and attention to human health. As a result,…
(more)
▼ The concept of self-management has been mentioned
frequently in the medical field due to the stronger awareness and
attention to human health. As a result, the self-management
intervention (SMI) is introduced as the support tool by some
medical providers such as doctors. The traditional intervention
relies on the providers and it will cost unnecessary resources and
the effect of the common intervention is also limited. It is
reported that 95% of Americans have an active smartphone
subscription and the wearable devices are becoming more affordable
and accurate. Therefore, the optimization of the self-management
intervention based on the novel mobile technology can be realized.
Thus, the author proposed a mobile software system that combines
the portable device, the android app, and the Internet message
service in order to provide self-tailor interventions for the
users. The core principle of the design is the skills of
self-management (problem solving, decision making, resource
utilization, the formation of a patient-provider partnership,
action planning, and self-tailoring). Multiple functions utilizing
sensor data and user's information are designed to assist to
provide more information to the users, create a self-tailoring plan
and strengthen the relationship between the users and providers.
There are two projects, Path2Quit (smoking cessation project) and
ADAPT (SMI for mobility impairments), developed based on this
system and the results of the pilot tests proved that the
efficiency of users' healthful self-management and the satisfaction
level of the intervention are increased with the involvement of the
software system according to the feedback from the
users.
Advisors/Committee Members: Huang, Ming-Chun (Advisor).
Subjects/Keywords: Computer Engineering; Self-management intervention; mHealth; mobile application; motion detection; system design
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chen, T. (2019). The Mobile Software System Design to Provide Self-management
Healthful Intervention. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554220151544945
Chicago Manual of Style (16th Edition):
Chen, Taiyu. “The Mobile Software System Design to Provide Self-management
Healthful Intervention.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554220151544945.
MLA Handbook (7th Edition):
Chen, Taiyu. “The Mobile Software System Design to Provide Self-management
Healthful Intervention.” 2019. Web. 26 Feb 2020.
Vancouver:
Chen T. The Mobile Software System Design to Provide Self-management
Healthful Intervention. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554220151544945.
Council of Science Editors:
Chen T. The Mobile Software System Design to Provide Self-management
Healthful Intervention. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554220151544945
21.
Song, Bolin.
Dynamic Co-occurrence of Local Anisotropic Gradient
Orientations (DyCoLIAGe) Descriptors from Pre-treatment Perfusion
DSC-MRI to Predict Overall Survival in Glioblastoma.
Degree: MSs, Biomedical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554299860994274
► A significant clinical challenge in glioblastoma is to risk-stratify patients for clinical trials, preferably using MRI scans. Radiomics involves mining of sub-visual features that could…
(more)
▼ A significant clinical challenge in glioblastoma is to
risk-stratify patients for clinical trials, preferably using MRI
scans. Radiomics involves mining of sub-visual features that could
serve as surrogate markers of tumor heterogeneity from routine
imaging. Previously our group had developed a new gradient-based
radiomic descriptor, Co-occurrence of Local Anisotropic Gradient
Orientations (COLLAGE), to capture tumor heterogeneity on
structural MRI. I present an extension of CoLLAGE on perfusion MRI,
termed dynamic COLLAGE (DyCoLIAGe), and demonstrate its application
in predicting overall survival in glioblastoma. Following manual
segmentation, 52 CoLIAGe features were extracted from edema and
enhancing tumor at different time phases during contrast
administration of perfusion MRI. Each feature was separately
plotted across different time-points, and a 3rd-order polynomial
was fit to each feature curve. The corresponding polynomial
coefficients were evaluated in terms of their prognosis
performance. My results suggest that DyCoLIAGe may be prognostic of
overall survival in glioblastoma.
Advisors/Committee Members: Tiwari, Pallavi (Committee Chair).
Subjects/Keywords: Biomedical Engineering
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Song, B. (2019). Dynamic Co-occurrence of Local Anisotropic Gradient
Orientations (DyCoLIAGe) Descriptors from Pre-treatment Perfusion
DSC-MRI to Predict Overall Survival in Glioblastoma. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554299860994274
Chicago Manual of Style (16th Edition):
Song, Bolin. “Dynamic Co-occurrence of Local Anisotropic Gradient
Orientations (DyCoLIAGe) Descriptors from Pre-treatment Perfusion
DSC-MRI to Predict Overall Survival in Glioblastoma.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554299860994274.
MLA Handbook (7th Edition):
Song, Bolin. “Dynamic Co-occurrence of Local Anisotropic Gradient
Orientations (DyCoLIAGe) Descriptors from Pre-treatment Perfusion
DSC-MRI to Predict Overall Survival in Glioblastoma.” 2019. Web. 26 Feb 2020.
Vancouver:
Song B. Dynamic Co-occurrence of Local Anisotropic Gradient
Orientations (DyCoLIAGe) Descriptors from Pre-treatment Perfusion
DSC-MRI to Predict Overall Survival in Glioblastoma. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554299860994274.
Council of Science Editors:
Song B. Dynamic Co-occurrence of Local Anisotropic Gradient
Orientations (DyCoLIAGe) Descriptors from Pre-treatment Perfusion
DSC-MRI to Predict Overall Survival in Glioblastoma. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554299860994274
22.
Rose, Evan Noah.
Autoignition Dynamics and Combustion of n-Dodecane
Dropletsunder Transcritical Conditions.
Degree: MSs, EMC - Mechanical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554288408975334
► Understanding the spontaneous ignition and burning behavior of liquid fuels is criticalto improving the performance of modern combustion devices. This work examinesthe effects of varying…
(more)
▼ Understanding the spontaneous ignition and burning
behavior of liquid fuels is criticalto improving the performance of
modern combustion devices. This work examinesthe effects of varying
ambient temperature and pressure on the autoignition and
burningcharacteristics of fiber-supported n-dodecane fuel droplets
in normal gravity and inmicrogravity. Ambient temperatures and
pressures were 500 to 1000 K and 1 to 25 atm,respectively,
encompassing the transcritical region for n-dodecane. The results
show thedynamics of ignition with the formation of a cool-flame
front and a hot-flame front priorto the final establishment of a
diffusion flame surrounding the droplet. These phenomenaare
observed for both normal gravity and microgravity environments.
Measurementof two-stage ignition delay times shows qualitative
agreement with previous research.
Advisors/Committee Members: Nayagam, Vedha (Advisor).
Subjects/Keywords: Mechanical Engineering; combustion; autoignition; ignition; droplet; NTC; two-stage ignition; dodecane
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rose, E. N. (2019). Autoignition Dynamics and Combustion of n-Dodecane
Dropletsunder Transcritical Conditions. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554288408975334
Chicago Manual of Style (16th Edition):
Rose, Evan Noah. “Autoignition Dynamics and Combustion of n-Dodecane
Dropletsunder Transcritical Conditions.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554288408975334.
MLA Handbook (7th Edition):
Rose, Evan Noah. “Autoignition Dynamics and Combustion of n-Dodecane
Dropletsunder Transcritical Conditions.” 2019. Web. 26 Feb 2020.
Vancouver:
Rose EN. Autoignition Dynamics and Combustion of n-Dodecane
Dropletsunder Transcritical Conditions. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554288408975334.
Council of Science Editors:
Rose EN. Autoignition Dynamics and Combustion of n-Dodecane
Dropletsunder Transcritical Conditions. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554288408975334
23.
Huang, Qianwen.
ION SOLVATION, MOBILITY AND ACCESSIBILITY IN IONIC LIQUID
ELECTROLYTES FOR ENERGY STORAGE.
Degree: PhD, Chemical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554307805686704
► Ionic liquids (ILs) are salts that consist of only ions and are in a liquid phase at ambient temperature. Their unique properties, including non-flammability, negligible…
(more)
▼ Ionic liquids (ILs) are salts that consist of only
ions and are in a liquid phase at ambient temperature. Their unique
properties, including non-flammability, negligible volatility, wide
electrochemical stability window, high thermal stability, and
structural tunability, enable ILs promising electrolytes for safer
energy storage devices, such as lithium-metal batteries. Lithium
metal batteries have about ten times higher theoretical energy
density than traditional lithium-ion batteries. However, due to the
high reactivity of the metallic lithium electrode, dendrites
(needle-like electrodeposits) can form during battery charging and
discharging. The formation of lithium dendrites can lead to
efficiency loss, capacity decay, short circuits and thermal
runaway. To address these safety challenges, a promising approach
is to replace the carbonate organic electrolyte solvents with ILs.
However, the slow lithium ion transport in IL-based electrolytes
limits the charging and discharging rates of a rechargeable battery
for practical applications. In this research, we developed IL
mixtures with decreased viscosity and increased lithium ion
mobility. These IL-based electrolytes demonstrate increased
stability at room temperature in the Li-LFP cells where lithium
metal is the anode and lithium iron phosphate, LiFePO4 (LFP) is the
cathode. ILs are also being explored for use in supercapacitors
with high power density due to their wide electrochemical window.
However, the main challenge of such application is the poor
wettability of ILs to porous electrodes. To address this challenge,
we investigate a novel hybrid material designed in the form of a
capsule with reduced graphene oxide shell and IL core (rGO-IL) that
eliminates some of the challenges with wettability. Increased
capacitance (based on active material mass, rGO) and surface
utilization have been achieved in supercapacitors with the designed
rGO-IL capsules. It is recognized that the developed rGO-IL
material may have broader scientific impacts such as the CO2
separation processes. A current pressing need in CO2 capture from
process exhaust gases or even air is the discovery of materials
that have high CO2 capacity and selectivity without kinetic
limitations. ILs have high CO2 solubility, however suffer from
large viscosities which imposes mass transport challenges for CO2
uptake and separation. An explorative study on the utility of
rGO-IL materials for CO2 separation is carried out as a possible
future direction for the application of rGO-IL capsules.
Preliminary results demonstrate increased CO2 absorption capacity
with improved absorption mass transfer rate with GO-IL capsules,
compared to bulk ILs.
Advisors/Committee Members: Gurkan, Burcu (Advisor).
Subjects/Keywords: Chemical Engineering; Ionic liquid, energy storage, lithium batteries,
supercapacitors, CO2 capture
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APA (6th Edition):
Huang, Q. (2019). ION SOLVATION, MOBILITY AND ACCESSIBILITY IN IONIC LIQUID
ELECTROLYTES FOR ENERGY STORAGE. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554307805686704
Chicago Manual of Style (16th Edition):
Huang, Qianwen. “ION SOLVATION, MOBILITY AND ACCESSIBILITY IN IONIC LIQUID
ELECTROLYTES FOR ENERGY STORAGE.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554307805686704.
MLA Handbook (7th Edition):
Huang, Qianwen. “ION SOLVATION, MOBILITY AND ACCESSIBILITY IN IONIC LIQUID
ELECTROLYTES FOR ENERGY STORAGE.” 2019. Web. 26 Feb 2020.
Vancouver:
Huang Q. ION SOLVATION, MOBILITY AND ACCESSIBILITY IN IONIC LIQUID
ELECTROLYTES FOR ENERGY STORAGE. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554307805686704.
Council of Science Editors:
Huang Q. ION SOLVATION, MOBILITY AND ACCESSIBILITY IN IONIC LIQUID
ELECTROLYTES FOR ENERGY STORAGE. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554307805686704
24.
Haley, Rebecca M.
Dual Delivery of Anti-inflammatory and Anti-microbial Drugs
from Affinity Polymer Coated Sutures Parallels Wound Healing
Timeline.
Degree: MSs (Engineering), Biomedical Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362
► Surgical sutures are vulnerable to bacterial infections and biofilm formation. At the suture site, pain and undesirable, excess inflammation are additionally detrimental to wound healing.…
(more)
▼ Surgical sutures are vulnerable to bacterial
infections and biofilm formation. At the suture site, pain and
undesirable, excess inflammation are additionally detrimental to
wound healing. The development of a polymerized cyclodextrin (pCD)
coated surgical suture introduces the capability to locally deliver
both anti-inflammatory and anti-microbial drugs throughout the
phases of acute and chronic healing. Local delivery allows for the
improvement of wound healing while reducing related systemic side
effects and drug resistance. Through testing, it has been shown
that the fabrication of this pCD coating minimally affects the
suture’s mechanical properties. In-vitro
studies show measurable
and consistent drug delivery for nearly five weeks. The therapeutic
level of this delivery is sufficient to show inhibition of
bacterial growth for four weeks, and free-radical scavenging (an
in-vitro anti-inflammatory activity approximation) for two weeks.
With this pCD coating technique, we maintain clinical performance
standards while also introducing a long-term dual delivery system
relevant to the wound healing timeframe.
Advisors/Committee Members: von Recum, Horst (Advisor).
Subjects/Keywords: Biomedical Engineering; Biomedical Research; Engineering; Drug Delivery; Infection; Inflammation; Suture; Wound Healing; Cyclodextrin; Polymer; Hydrogel
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Haley, R. M. (2019). Dual Delivery of Anti-inflammatory and Anti-microbial Drugs
from Affinity Polymer Coated Sutures Parallels Wound Healing
Timeline. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362
Chicago Manual of Style (16th Edition):
Haley, Rebecca M. “Dual Delivery of Anti-inflammatory and Anti-microbial Drugs
from Affinity Polymer Coated Sutures Parallels Wound Healing
Timeline.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362.
MLA Handbook (7th Edition):
Haley, Rebecca M. “Dual Delivery of Anti-inflammatory and Anti-microbial Drugs
from Affinity Polymer Coated Sutures Parallels Wound Healing
Timeline.” 2019. Web. 26 Feb 2020.
Vancouver:
Haley RM. Dual Delivery of Anti-inflammatory and Anti-microbial Drugs
from Affinity Polymer Coated Sutures Parallels Wound Healing
Timeline. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362.
Council of Science Editors:
Haley RM. Dual Delivery of Anti-inflammatory and Anti-microbial Drugs
from Affinity Polymer Coated Sutures Parallels Wound Healing
Timeline. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362
25.
Gordon, Devin Alexander.
Quantifying the Weathering Induced Degradation of
Poly(ethylene-terephthalate) via Spectroscopic Chemometrics and
Statistical Modeling.
Degree: PhD, Macromolecular Science and Engineering, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554465169167998
► PET is widely used in engineering applications ranging from commonplace household systems to complex, technical devices.PET degrades under exposure to ultraviolet (UV) irradiance, heat, and…
(more)
▼ PET is widely used in engineering applications ranging
from commonplace household systems to complex, technical
devices.PET degrades under exposure to ultraviolet (UV) irradiance,
heat, and moisture, which leads to loss of optical clarity and
performance properties.Quantitative understanding of the
degradation of PET is a critical step on the path to the
development of longer lasting PET-based products with improved
performance.The physical properties of nine grades of PET films,
three clear and six TiO2-filled were modeled after outdoor and
accelerated weathering exposures to characterize the degradation
process of PET and assess the influence of stabilizing additives
and weathering factors. Multivariate multiple regression (MMR)
models were developed to quantify changes in color, gloss, and haze
of the materials. Natural splines were used to capture the
non-linear relationship between predictors and
responses.Cross-correlation between accelerated and outdoor
weathering exposure was achieved using the resulting MMR
models.Parallel factor analysis was applied alongside fluorescence
spectroscopy to identify and distinguish between the formation of
monohydroxy-terephthalate and dihydroxy-terephthalate units in PET
under accelerated exposure conditions.Principal component analysis
was utilized alongside ATR-FTIR to identify changes in the PET
aromatic ring substitution pattern, which supported findings from
EEM-PARAFAC.Overall, the work serves as an example of application
of data science methods, chemometrics, and statistical analysis to
the study of polymer degradation to strengthen the quantitative
nature of conclusions in the field.
Advisors/Committee Members: French, Roger (Committee Chair), Bruckman, Laura (Advisor).
Subjects/Keywords: Polymers; Materials Science; Statistics; Mathematics; Polyethylene-terephthalate; Degradation; Chemometrics; Statistical Modeliing; Weathering; Applied Spectroscopy
Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gordon, D. A. (2019). Quantifying the Weathering Induced Degradation of
Poly(ethylene-terephthalate) via Spectroscopic Chemometrics and
Statistical Modeling. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554465169167998
Chicago Manual of Style (16th Edition):
Gordon, Devin Alexander. “Quantifying the Weathering Induced Degradation of
Poly(ethylene-terephthalate) via Spectroscopic Chemometrics and
Statistical Modeling.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554465169167998.
MLA Handbook (7th Edition):
Gordon, Devin Alexander. “Quantifying the Weathering Induced Degradation of
Poly(ethylene-terephthalate) via Spectroscopic Chemometrics and
Statistical Modeling.” 2019. Web. 26 Feb 2020.
Vancouver:
Gordon DA. Quantifying the Weathering Induced Degradation of
Poly(ethylene-terephthalate) via Spectroscopic Chemometrics and
Statistical Modeling. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554465169167998.
Council of Science Editors:
Gordon DA. Quantifying the Weathering Induced Degradation of
Poly(ethylene-terephthalate) via Spectroscopic Chemometrics and
Statistical Modeling. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554465169167998
26.
Cavanagh, Kevin V.
GAMIFICATION AS A VEHICLE TO ENCOURAGE BEHAVIOR
CHANGE.
Degree: PhD, Organizational Behavior, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554377747022203
► Intentional Change Theory (ICT) has been shown to be effective in helping students develop emotional, social, and cognitive competencies. However, when individuals set goals to…
(more)
▼ Intentional Change Theory (ICT) has been shown to be
effective in helping students develop emotional, social, and
cognitive competencies. However, when individuals set goals to help
them move closer to their vision,
studies show they often have a
negative response. In order for goal-setting to be effective, the
process needs to be enjoyable and exciting. Gamification, the use
of game design elements in non-game contexts, has experienced a
meteoric rise in mainstream research literature over the past
decade. On the whole, gamification seeks to increase engagement by
providing a fun experience for the end user. Through the
goal-setting process of ICT (e.g., the Learning Agenda), this study
examines the extent to which goal-setting is more enjoyable through
a gamification approach. An experimental design (e.g., gamified vs.
a non-gamified control) is used to examine the impact that
gamification has a goal-setting in undergraduate and
graduate
populations at
Case Western Reserve University. Results of this
experiment show that students who experienced the gamified model
were more likely to think about their goals after the course ended
and more likely to reach out to others for social support. The
results also showed that students in the experimental condition
were less scared and upset than those who did not experience the
gamified packet. Discussion of these findings, limitations of this
research, and future research are discussed.
Advisors/Committee Members: Boyatzis, Richard (Committee Chair).
Subjects/Keywords: Organizational Behavior
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MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cavanagh, K. V. (2019). GAMIFICATION AS A VEHICLE TO ENCOURAGE BEHAVIOR
CHANGE. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554377747022203
Chicago Manual of Style (16th Edition):
Cavanagh, Kevin V. “GAMIFICATION AS A VEHICLE TO ENCOURAGE BEHAVIOR
CHANGE.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554377747022203.
MLA Handbook (7th Edition):
Cavanagh, Kevin V. “GAMIFICATION AS A VEHICLE TO ENCOURAGE BEHAVIOR
CHANGE.” 2019. Web. 26 Feb 2020.
Vancouver:
Cavanagh KV. GAMIFICATION AS A VEHICLE TO ENCOURAGE BEHAVIOR
CHANGE. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554377747022203.
Council of Science Editors:
Cavanagh KV. GAMIFICATION AS A VEHICLE TO ENCOURAGE BEHAVIOR
CHANGE. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554377747022203
27.
Mohamed Hag, Amani MI.
WEIGHT LOSS MEDICATION: A PRELIMINARY STUDY TO ASSESS IF IT
WORKS.
Degree: MSs, Clinical Research, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554472321010433
► Background: Obesity is a rising global health problem (1,2). It is associated with increased incidence of chronic diseases such as Type 2 diabetes, heart disease,…
(more)
▼ Background: Obesity is a rising global health problem
(1,2). It is associated with increased incidence of chronic
diseases such as Type 2 diabetes, heart disease, hypertension,
cancer and mortality (3-6). Life style intervention including
dietary modification and exercise are suggested as the first step
to treat obesity (7). However, successful weight loss and
maintenance of the results maybe hard to achieve. In these
circumstances, pharmacotherapy is indicated (8). Objective: This
study represents an initial step in assessing comparative efficacy
of weight loss medications. We hypothesized that weight loss
medications would be differentially associated with observed weight
loss over time in our study sample. Methods: A retrospective study
of 543 patients with obesity recruited from the Cleveland Clinic
Bariatric and Metabolic Institute between January 2000 and December
2013 who received weight loss medications, which included five FDA
approved medications.Results: Of the 543 patients receiving weight
loss medication, 67% of the study cohort showed weight loss of 2.5%
at six months, and 62% showed weight loss of 2.6% at 12 months.
Conclusion: The study provided preliminary evidence that weight
loss medications can be useful in patients who have not achieved
weight loss with life style modifications alone.
Advisors/Committee Members: Spilsbury, James (Committee Chair).
Subjects/Keywords: Medicine
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mohamed Hag, A. M. (2019). WEIGHT LOSS MEDICATION: A PRELIMINARY STUDY TO ASSESS IF IT
WORKS. (Masters Thesis). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554472321010433
Chicago Manual of Style (16th Edition):
Mohamed Hag, Amani MI. “WEIGHT LOSS MEDICATION: A PRELIMINARY STUDY TO ASSESS IF IT
WORKS.” 2019. Masters Thesis, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554472321010433.
MLA Handbook (7th Edition):
Mohamed Hag, Amani MI. “WEIGHT LOSS MEDICATION: A PRELIMINARY STUDY TO ASSESS IF IT
WORKS.” 2019. Web. 26 Feb 2020.
Vancouver:
Mohamed Hag AM. WEIGHT LOSS MEDICATION: A PRELIMINARY STUDY TO ASSESS IF IT
WORKS. [Internet] [Masters thesis]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554472321010433.
Council of Science Editors:
Mohamed Hag AM. WEIGHT LOSS MEDICATION: A PRELIMINARY STUDY TO ASSESS IF IT
WORKS. [Masters Thesis]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554472321010433
28.
ZHAO, JING.
EFFECTS OF LOCAL RNA SEQUENCE AND STRUCTURAL CONTEXTS ON
RIBONUCLEASE P PROCESSING SPECIFICITY.
Degree: PhD, Biochemistry, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554396751955631
► The affinity and kinetics of RNA and protein association depends on the stability of the RNA-protein complex as well as the structure and stability of…
(more)
▼ The affinity and kinetics of RNA and protein
association depends on the stability of the RNA-protein complex as
well as the structure and stability of the free RNA and protein.
While much is known about how proteins and enzymes bind their
specific sites in RNA, less is understood about the effects of RNA
sequence and structure contexts surrounding these specific binding
sites on binding. Ribonuclease P (RNase P) is a ribonucleoprotein
enzyme involved in tRNA processing that relies on the protein
subunit that forms essential contacts to a linear sequence of 3-8
nucleotides in the 5′ leader of precursor tRNA (ptRNA). Therefore,
binding is likely to be influenced by the presence of competing
secondary structure in the free RNA leader sequence. To address
this issue, we pursued two primary lines of investigation. First,
we compared the kinetics of RNA cleavage in monocistronic and
polycistronic ptRNAs, which offers the opportunity to investigate
the role of local RNA contexts on recognition. Kinetic analysis by
using single turnover kinetics in vitro, cleavage site mapping and
uniform substrate labelling on polycistronic ptRNAval VW reproduces
the 3′ to 5′ ordered processing observed in vivo suggesting this is
the most predominant pathway by RNase P. In-line probing further
reveals the effects of both ptRNAs order and leader structure on
directional processing. Kinetic analysis on valV and valW
individually suggests that valV is an intrinsically slow and valW
is an intrinsically fast substrate due to the leader structure on
valV. Therefore, ordered processing can arise from the ability of
genomically encoded sequences to form inhibitory secondary
structure proximal to the RNase P cleavage site that inhibits
processing.In a parallel experiment, we designed three different
ptRNA substrate pools with randomized leader sequences proximal to
the RNase P cleavage site, but with different RNA sequences
appended upstream. Using a high throughput approach the rate
constants for all the individual RNA substrates in the population
were determined, and the resulting data was analyzed to test the
effect of variation in both sequence and secondary structure on
processing specificity globally. The effects of two upstream
extensions (21A and 21B) containing transversion mutations were
compared. Also, a third population (21C) was designed to form a
stable stem loop that should insulate the randomized protein
binding site from the effects of inhibitory interactions with
additional leader sequences. Using a high-throughput sequencing
kinetics (HiTS-KIN) method, we determined the rate constants for
all sequence variants at N (-1) to N(-6) in the 21A, B and C
backgrounds. Comparison of the three HiTS-KIN data clearly
demonstrates that formation of inhibitory secondary structures
influences the association kinetics of a subset of substrates.
Together, the comparative HiTS-KIN analyses in vitro and
mechanistic basis of ordered genomic encoded polycistronic ptRNAs
processing demonstrate the contribution of structure and sequence
variations to…
Advisors/Committee Members: HARRIS, MICHEAL (Advisor), JANKOWSKY, ECKHARD (Committee Chair).
Subjects/Keywords: Biochemistry; Biostatistics; tRNA processing; ribonuclease P; high throughput sequencing; secondary structure; polycistronic
Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
ZHAO, J. (2019). EFFECTS OF LOCAL RNA SEQUENCE AND STRUCTURAL CONTEXTS ON
RIBONUCLEASE P PROCESSING SPECIFICITY. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554396751955631
Chicago Manual of Style (16th Edition):
ZHAO, JING. “EFFECTS OF LOCAL RNA SEQUENCE AND STRUCTURAL CONTEXTS ON
RIBONUCLEASE P PROCESSING SPECIFICITY.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554396751955631.
MLA Handbook (7th Edition):
ZHAO, JING. “EFFECTS OF LOCAL RNA SEQUENCE AND STRUCTURAL CONTEXTS ON
RIBONUCLEASE P PROCESSING SPECIFICITY.” 2019. Web. 26 Feb 2020.
Vancouver:
ZHAO J. EFFECTS OF LOCAL RNA SEQUENCE AND STRUCTURAL CONTEXTS ON
RIBONUCLEASE P PROCESSING SPECIFICITY. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554396751955631.
Council of Science Editors:
ZHAO J. EFFECTS OF LOCAL RNA SEQUENCE AND STRUCTURAL CONTEXTS ON
RIBONUCLEASE P PROCESSING SPECIFICITY. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554396751955631
29.
Peters, Kyle C.
Sustainable Materials and Processes for Optoelectronic
Applications.
Degree: PhD, Physics, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554397264722736
► Organic and polymeric materials have received considerable attention in the past several decades for their potential as active electronic and optical materials. This interest arises…
(more)
▼ Organic and polymeric materials have received
considerable attention in the past several decades for their
potential as active electronic and optical materials. This interest
arises from the high level of function, manufacturability, and
synthetic tailorability toward function and structure. In this
thesis, I focus on sustainable approaches to create optofunctional
materials as well as methods for thin film processing to achieve
scalable, low-cost avenues for organic optoelectronic
devices.Bioinspired molecular self-assembly provides an attractive
approach to construct nanoarchitectures for high-performance
(opto)functional materials by exploiting the light-harvesting and
self-organizing abilities of Nature. The first part of this thesis
investigates the self-assembling abilities and light-matter
properties of novel biosurfactant- functionalized porphyrin
chromophores. It is found that the self-assembly process is driven
by a combination of hydrogen-bond, steric, and π-π interactions. In
dilute methanol/water solution, we found that excitonically coupled
helical structures form by strong carbohydrate hydrogen-bonding
interactions. Furthermroe, it was discovered that shortening of the
sophorolipid hydrocarbon chain promotes helical reversal that is
accompanied with a large increase in the cooperative nature of
assembled structures. Solution and other fluid-state processing
approaches for organic semiconductors provide low-cost, large area
applications for flexible electronics, organic photovoltaics and
organic light emitting diodes. However, many processing techniques
depend on organic solvents and are subjected to large material
waste. The second part of this thesis adapts electrocoating—an
aqueous-based industrial-scale technique—to fabricate
semiconducting polymer thin films and graphene oxide layers for
functional components in photovoltaic solar cells. It was found
that electrocoated film thickness was controlled readily by applied
voltage and the optoelectronic properties of these films were
comparable to films made by spin-coating. Results suggest that
electro- coating is a promising deposition method for organic
electronic applications including conformal deposition onto complex
shaped surfaces for low-cost and environmentally friendly nanoscale
film formation.
Advisors/Committee Members: Singer, Kenneth (Committee Chair).
Subjects/Keywords: Physics; Materials Science; Nanoscience; Physical Chemistry
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Peters, K. C. (2019). Sustainable Materials and Processes for Optoelectronic
Applications. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554397264722736
Chicago Manual of Style (16th Edition):
Peters, Kyle C. “Sustainable Materials and Processes for Optoelectronic
Applications.” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554397264722736.
MLA Handbook (7th Edition):
Peters, Kyle C. “Sustainable Materials and Processes for Optoelectronic
Applications.” 2019. Web. 26 Feb 2020.
Vancouver:
Peters KC. Sustainable Materials and Processes for Optoelectronic
Applications. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554397264722736.
Council of Science Editors:
Peters KC. Sustainable Materials and Processes for Optoelectronic
Applications. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554397264722736
30.
Leeds, Charles Austin.
A Physiological Evaluation of Social Bonding in Western
Lowland Gorillas (Gorilla gorilla gorilla).
Degree: PhD, Biology, 2019, Case Western Reserve University School of Graduate Studies
URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1554396989561718
► The strength of one’s social bonds has direct links to fitness, health and welfare. Evaluations of social bond strength are relatively straightforward for gregarious species…
(more)
▼ The strength of one’s social bonds has direct links to
fitness, health and welfare. Evaluations of social bond strength
are relatively straightforward for gregarious species through
direction observation of affiliative behavior, but can prove
difficult for less gregarious species. The
western lowland gorilla
(WLG: Gorilla gorilla gorilla) is one such social species that
engages in low rates of affiliative behavior. Assessing variation
in the neuroendocrine hormone oxytocin (OXT), which is the
physiological driver of social bonds, in relation to social
demographic variables may prove useful to better understand how
gorilla form bonds and how these bonds vary in the zoo environment.
The overall objective of this dissertation was to evaluate
variation in WLG salivary and urinary OXT. Biological samples were
collected from 143 gorillas living at 25 zoos. Using both
experimental and exploratory methodology, this dissertation
successfully validated the measurement of OXT in unextracted WLG
saliva and urine. Specifically, significant changes in both
salivary and urinary OXT were detected following an intranasal
challenge and spontaneous social events. This methodology was then
used to assess variation in OXT following interactions with animal
care staff (ACS) and in baseline samples. Following positive
reinforcement training with ACS, salivary OXT concentrations did
not change, but OXT did increase following play with ACS. This
indicates that relationships between WLG and ACS in zoos, at least
in certain contexts, are viewed as positive and affiliative by WLG.
In a large-scale evaluation of OXT, multiple demographic and
husbandry factors were associated with variation in OXT. Notably,
OXT was greater in males living in bachelor groups compared to
mixed-sex groups, providing evidence that male WLG form
comparatively stronger bonds with other males than with females.
This is supported by field
studies of WLG that demonstrate males
form dispersed, affiliative social networks with related males.
Greater OXT concentrations were also associated with lactation in
female WLG. This finding was expected based on the natural
functioning of OXT and further validated our measurement of OXT in
unextracted urine. Lastly, ACS perceptions of bonding were assessed
in relation to OXT. Interestingly, ACS ratings of social bonding
did not differ between mixed-sex and bachelor groups, indicating
ACS perceive both group types to provide meaningful social
environments for WLG. ACS also identified peripheral group members
within their respective WLG groups. Peripheral status was
negatively associated with OXT concentrations, indicating more
socially distant group members maintained comparatively weaker
social bonds than more integrated group members. Overall, these
findings have improved our understanding of how WLG form social
bonds and how social bonds vary in relation to husbandry and
management practices. Of specific importance, this study further
demonstrates the significant social value of bachelor groups for
male WLG.
Advisors/Committee Members: Lukas, Kristen (Committee Chair).
Subjects/Keywords: Biology; western lowland gorilla; oxytocin; social bonding; zoo; welfare
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APA (6th Edition):
Leeds, C. A. (2019). A Physiological Evaluation of Social Bonding in Western
Lowland Gorillas (Gorilla gorilla gorilla). (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1554396989561718
Chicago Manual of Style (16th Edition):
Leeds, Charles Austin. “A Physiological Evaluation of Social Bonding in Western
Lowland Gorillas (Gorilla gorilla gorilla).” 2019. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2020.
http://rave.ohiolink.edu/etdc/view?acc_num=case1554396989561718.
MLA Handbook (7th Edition):
Leeds, Charles Austin. “A Physiological Evaluation of Social Bonding in Western
Lowland Gorillas (Gorilla gorilla gorilla).” 2019. Web. 26 Feb 2020.
Vancouver:
Leeds CA. A Physiological Evaluation of Social Bonding in Western
Lowland Gorillas (Gorilla gorilla gorilla). [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2019. [cited 2020 Feb 26].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554396989561718.
Council of Science Editors:
Leeds CA. A Physiological Evaluation of Social Bonding in Western
Lowland Gorillas (Gorilla gorilla gorilla). [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1554396989561718
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