publisher:("Cardiff University")

Cardiff University

1. Williams, Emma. Lies and Cognition:How do we tell lies and can we detect them?.

Degree: phd, 2012, Cardiff University

► The aims of the present thesis are twofold. Firstly, to examine the particular cognitive processes that are involved in telling lies, and how they differ… (more)

▼ The aims of the present thesis are twofold. Firstly, to examine the particular cognitive processes that are involved in telling lies, and how they differ from those involved in telling the truth, in a variety of different circumstances. Secondly, to examine the different factors that affect human ability to detect deception, with a particular focus on individual and cultural differences in both detection accuracy and response bias. In relation to the first aim, a minimalist approach was taken, which allowed us to examine the contribution of individual cognitive processes to telling a lie. A simple computer task was developed, whereby participants lied and told the truth regarding the colour of a square and their vocal response times recorded. Response times have been shown to be greater when individuals lie compared to when they tell the truth, which supports the idea that additional processes are required in order to tell a lie. The relative contribution of these processes, and the factors that may affect this, remain unknown. Our experiments allow for an extension of previous work regarding the theoretical understanding of why telling a lie is more difficult than telling the truth, as well as the factors that may decrease or increase this difference. Since our experiments demonstrated that telling a lie does involve additional processes compared to telling the truth, and that this is reflected in measurable behavioural differences, our second aim was to examine the judgement factors that may affect the ability to identify this enhanced difficulty and accurately detect deception. In relation to the second aim, human ability to detect deception was examined through the creation of video statements of individuals both truthfully and falsely describing an image they had previously viewed on a computer screen. Some of these statements were provided by individuals of the same cultural background as the judge, whilst others were provided by individuals of a different cultural background to the judge. Judges viewed these statements and evaluated whether they thought each one was truthful or a lie, as well as completing a variety of individual difference measures related to the ability to correctly interpret the behaviour and mental states of others. These experiments allowed us to examine possible relationships between both individual difference measuresand cultural background, on response bias and judgement accuracy, thus extending previous judgement studies.

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APA (6^th Edition):

Williams, E. (2012). Lies and Cognition:How do we tell lies and can we detect them?. (Doctoral Dissertation). Cardiff University. Retrieved from http://opus.bath.ac.uk/49081/

Chicago Manual of Style (16^th Edition):

Williams, Emma. “Lies and Cognition:How do we tell lies and can we detect them?.” 2012. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://opus.bath.ac.uk/49081/.

MLA Handbook (7^th Edition):

Williams, Emma. “Lies and Cognition:How do we tell lies and can we detect them?.” 2012. Web. 10 Apr 2021.

Vancouver:

Williams E. Lies and Cognition:How do we tell lies and can we detect them?. [Internet] [Doctoral dissertation]. Cardiff University; 2012. [cited 2021 Apr 10]. Available from: http://opus.bath.ac.uk/49081/.

Council of Science Editors:

Williams E. Lies and Cognition:How do we tell lies and can we detect them?. [Doctoral Dissertation]. Cardiff University; 2012. Available from: http://opus.bath.ac.uk/49081/

Cardiff University

2. Abd Rahman, Rahisham. Investigations of ZnO microvaristor for stress control on polymeric outdoor insulators.

Degree: School of Engineering, 2012, Cardiff University

URL: http://eprints.uthm.edu.my/id/eprint/4674/

► This thesis is concerned with the investigation of the efficiency of Zinc Oxide microvaristor compound for stress control on polymeric outdoor insulators. The preliminary work… (more)

▼ This thesis is concerned with the investigation of the efficiency of Zinc Oxide microvaristor compound for stress control on polymeric outdoor insulators. The preliminary work has involved a comprehensive literature survey, followed by extensive computational modelling and simulation studies as well as laboratory works covering experimental investigations and fabrication of insulator prototypes. The literature survey reviewed stress-induc2d degradations as the cause of ageing and insulation failures, the determination of electric field distributions, considerations for outdoor insulator modelling, and field-optimisation techniques for achieving stress relief. An 11 kV polymeric insulator has been modelled and simulated under dry-clean and wet-polluted surface conditions in order to obtain electric field distribution along the insulator creepage path. The critical high field regions on polymeric surfaces were identified. In addition, clean fog solid layer tests were carried out to experimentally examine dry band formation and electric discharges. Experimental investigations confirmed the results previously achieved from theoretical simulations. A non-linear pollution model has been developed for simulating polluted outdoor insulators. The field-dependent conductivity was derived from layer conductance measurements in a non-standard low voltage test. The proposed model was used to simulate insulators under fog and light rain conditions yhich respectively represent a uniform and non-uniform wetting action in practice. It was demonstrated that the nonlinear pollution model yields a more detailed and realistic field distribution compared with results obtained with models using constant/linear conductivity. Short-length microvaristor coating, having a cone-shaped structure, was introduced at both insulator ends for controlling high field, pirticularly near the high voltage and ground terminals. The performance of field grading was evaluated through a number of simulation scenarios. The introduction of microvaristor material with an appropriate switching characteristic has led to a substantial improvement in the electric field and heat distributions along the insulator profile. . The prototype of an 1 lkV insulator with microvaristor grading material was fabricated in-house for preliminary tests. Lightning impulse (1.2150 ps) flashover tests were carried out using the 'up and down' method, and the flashover voltage was estimated by the 50% probability breakdown, Use. The results of the lightning impulse test have indicated a considerable increase in the flashover voltage up to 21% when using microvaristor-graded insulator. Favourable field distributions obtained in the simulation study have indicated a strong correlation with the experimental results.

Subjects/Keywords: TK3001-3521 Distribution or transmission of electric power

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APA (6^th Edition):

Abd Rahman, R. (2012). Investigations of ZnO microvaristor for stress control on polymeric outdoor insulators. (Thesis). Cardiff University. Retrieved from http://eprints.uthm.edu.my/id/eprint/4674/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abd Rahman, Rahisham. “Investigations of ZnO microvaristor for stress control on polymeric outdoor insulators.” 2012. Thesis, Cardiff University. Accessed April 10, 2021. http://eprints.uthm.edu.my/id/eprint/4674/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abd Rahman, Rahisham. “Investigations of ZnO microvaristor for stress control on polymeric outdoor insulators.” 2012. Web. 10 Apr 2021.

Vancouver:

Abd Rahman R. Investigations of ZnO microvaristor for stress control on polymeric outdoor insulators. [Internet] [Thesis]. Cardiff University; 2012. [cited 2021 Apr 10]. Available from: http://eprints.uthm.edu.my/id/eprint/4674/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abd Rahman R. Investigations of ZnO microvaristor for stress control on polymeric outdoor insulators. [Thesis]. Cardiff University; 2012. Available from: http://eprints.uthm.edu.my/id/eprint/4674/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cardiff University

3. Kamarudin, Muhammad Saufi. Experimental investigation of cf3i-co2 gas mixtures on the breakdown characteristics in uniform and nonuniform field configurations .

Degree: phd, School of Engineering, 2013, Cardiff University

URL: http://eprints.uthm.edu.my/id/eprint/7799/

► This thesis is concerned with the investigation of trifluoroiodomethane (CF3I) gas mixtures as an alternative for an insulation medium in high voltage applications. The work… (more)

▼ This thesis is concerned with the investigation of trifluoroiodomethane (CF3I) gas mixtures as an alternative for an insulation medium in high voltage applications. The work has involved a broad review of literature, followed by developing a test rig for carrying out experimental investigations, extensive computational modelling and simulation studies as well as extensive laboratory tests on CF3I gas and its gas mixtures. The literature survey reviewed the current trend of efforts taken by researchers to find solutions for minimizing the usage of sulphur hexafluoride (SF6) as a gas insulator, focusing on CF3I and its mixtures. The physical properties of CF3I are investigated, along with thermal and electrical properties. A new test rig has been designed and constructed specifically to be used for gas insulation research. The test rig is integrated with wireless temperature and humidity sensors, as well as an electrode gap length control system. The test rig is completed with a gas recovery system to ensure proper gas handling is carried out after each test. Extensive laboratory experimental investigations on CF3I mixtures have been completed, focusing on the mixture of CF3I-CO2 gas with a ratio of 30%-70%. Standard lightning impulse of 1.2/50 has been used, with both positive and negative polarity. The effects of electrode configuration, impulse polarity, electrode gap length, gas pressure, and CF3I content have been investigated. Insulation properties such as 50% breakdown voltage (U50) and V-t characteristics for each test condition are investigated and presented, as well as the electric field behaviour. Finite element method (FEM) has been used to determine the electric field behaviour of a given test condition. This study revealed that CF3I gas mixtures perform better under more uniform field condition. It was also found that an increase in gas pressure will increase the insulation strength and an increase in CF3I content is more likely to give benefit in conditions with a more uniform field when compared to less uniform field conditions. Also, relation between liquefaction temperatures of a CF3I-CO2 mixture with varying CF3I content has been developed for various pressures based on literature. Observations on solid by-products of CF3I have also been carried out. It has been found that iodine particles are deposited on both high voltage and ground electrodes, which can affect the insulation properties of CF3I and its mixtures.

Subjects/Keywords: TK2000-2891 Dynamoelectric machinery and auxiliaries

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APA (6^th Edition):

Kamarudin, M. S. (2013). Experimental investigation of cf3i-co2 gas mixtures on the breakdown characteristics in uniform and nonuniform field configurations . (Doctoral Dissertation). Cardiff University. Retrieved from http://eprints.uthm.edu.my/id/eprint/7799/

Chicago Manual of Style (16^th Edition):

Kamarudin, Muhammad Saufi. “Experimental investigation of cf3i-co2 gas mixtures on the breakdown characteristics in uniform and nonuniform field configurations .” 2013. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://eprints.uthm.edu.my/id/eprint/7799/.

MLA Handbook (7^th Edition):

Kamarudin, Muhammad Saufi. “Experimental investigation of cf3i-co2 gas mixtures on the breakdown characteristics in uniform and nonuniform field configurations .” 2013. Web. 10 Apr 2021.

Vancouver:

Kamarudin MS. Experimental investigation of cf3i-co2 gas mixtures on the breakdown characteristics in uniform and nonuniform field configurations . [Internet] [Doctoral dissertation]. Cardiff University; 2013. [cited 2021 Apr 10]. Available from: http://eprints.uthm.edu.my/id/eprint/7799/.

Council of Science Editors:

Kamarudin MS. Experimental investigation of cf3i-co2 gas mixtures on the breakdown characteristics in uniform and nonuniform field configurations . [Doctoral Dissertation]. Cardiff University; 2013. Available from: http://eprints.uthm.edu.my/id/eprint/7799/

Cardiff University

4. Brown, Lloyd A. Banks and secured lending: environmental risks and due diligence.

Degree: PhD, 2014, Cardiff University

URL: http://orca.cf.ac.uk/80782/

► In the 1990s and early 2000s lender liability for the remediation of contaminated land was considered the greatest environmental risk for lenders. The threat of… (more)

Subjects/Keywords: K Law (General)

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APA (6^th Edition):

Brown, L. A. (2014). Banks and secured lending: environmental risks and due diligence. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/80782/

Chicago Manual of Style (16^th Edition):

Brown, Lloyd A. “Banks and secured lending: environmental risks and due diligence.” 2014. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/80782/.

MLA Handbook (7^th Edition):

Brown, Lloyd A. “Banks and secured lending: environmental risks and due diligence.” 2014. Web. 10 Apr 2021.

Vancouver:

Brown LA. Banks and secured lending: environmental risks and due diligence. [Internet] [Doctoral dissertation]. Cardiff University; 2014. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/80782/.

Council of Science Editors:

Brown LA. Banks and secured lending: environmental risks and due diligence. [Doctoral Dissertation]. Cardiff University; 2014. Available from: http://orca.cf.ac.uk/80782/

Cardiff University

5. Clinch, Susanne. Developing and evaluating behavioural tasks to assess basal ganglia function.

Degree: PhD, 2017, Cardiff University

URL: http://orca.cf.ac.uk/100957/

► Huntington’s disease (HD) is a primary example of a basal ganglia disorder, from which, medium spiny neurons in the striatum degenerate. As this causes a… (more)

▼ Huntington’s disease (HD) is a primary example of a basal ganglia disorder, from which, medium spiny neurons in the striatum degenerate. As this causes a breakdown in basal ganglia cortico-thalamic circuitry, this leads to a range of symptoms including motor, cognitive and behavioural deficits. One therapeutic option is to replace medium spiny neurons with precursor striatal cells and reconnect the lost circuitry. However, the lack of performance based functional outcome measures for people with HD have made it difficult to assess how the graft affects standards of daily living. Although neuroimaging techniques can be used to quantify the morphological and molecular effects that the intervention has on that brain region, and associated circuitry, an important question still remains, namely whether there has been any effect on functional ability. Using assessments that have high ecological validity, such as dual tasks could be a valuable measure, especially as previous studies suggest that the striatum is required for optimal performance in such tasks. Therefore the focus of this thesis was to design, develop and assess performance based functional tasks that involve the neurocircuity affected in HD; namely the basal ganglia. The aim of the study in Chapter 2 was to select, develop and evaluate motor-cognitive dual task paradigms for use in people with HD. The findings revealed that the Step and Stroop which targeted lower limb function, best distinguished disease stage in HD compared to the other lower limb assessments tested. During this experiment, it became apparent that upper limb assessments for people with HD were particularly limited. Therefore, in Part 2, a new upper limb dual task assessment was developed and called the Clinch token transfer test (C3t). The findings revealed that this was sensitive to disease stage and could provide a useful outcome measure for people with HD in the future. To take the findings from Chapter 2 further, a new, standardised C3t was developed. This version was evaluated, optimised, and then validated in a large group of people gene positive for HD, and in heathy controls. The findings revealed that the C3t significantly correlated with all the Unified Huntington Disease Rating Scale measures, successfully distinguished between all disease stages, and revealed that the performance in this task was also sensitive to the subtle disease symptoms in the early stages of HD. As the Stroop task is commonly used in people with HD, the aim of Chapter 3 was to use immediate early gene expression to identify if the striatum was activated during a rodent analogue of the Stroop task. The findings revealed what could be the first in a series of experiments in that, striatal activation significantly correlated with performance in the congruent and the incongruent versions of this test when compared to cage controls. The findings presented in this thesis support that dual task assessments could have an important role in assessing function in HD, which could translate to performance in tasks…

Subjects/Keywords: QH426 Genetics; RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

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APA (6^th Edition):

Clinch, S. (2017). Developing and evaluating behavioural tasks to assess basal ganglia function. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/100957/

Chicago Manual of Style (16^th Edition):

Clinch, Susanne. “Developing and evaluating behavioural tasks to assess basal ganglia function.” 2017. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/100957/.

MLA Handbook (7^th Edition):

Clinch, Susanne. “Developing and evaluating behavioural tasks to assess basal ganglia function.” 2017. Web. 10 Apr 2021.

Vancouver:

Clinch S. Developing and evaluating behavioural tasks to assess basal ganglia function. [Internet] [Doctoral dissertation]. Cardiff University; 2017. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/100957/.

Council of Science Editors:

Clinch S. Developing and evaluating behavioural tasks to assess basal ganglia function. [Doctoral Dissertation]. Cardiff University; 2017. Available from: http://orca.cf.ac.uk/100957/

Cardiff University

6. Roy Chowdhury, Sharmistha. Assessment of putative risk factors in the development of Diabetic Retinopathy in Wales.

Degree: md, 2016, Cardiff University

URL: http://orca.cf.ac.uk/101021/

► The aim of this thesis was to assess the relationships between glycaemic exposure and β-cell function with prevalence, incidence and progression of diabetic retinopathy (DR)… (more)

Subjects/Keywords: R Medicine (General)

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APA (6^th Edition):

Roy Chowdhury, S. (2016). Assessment of putative risk factors in the development of Diabetic Retinopathy in Wales. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/101021/

Chicago Manual of Style (16^th Edition):

Roy Chowdhury, Sharmistha. “Assessment of putative risk factors in the development of Diabetic Retinopathy in Wales.” 2016. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/101021/.

MLA Handbook (7^th Edition):

Roy Chowdhury, Sharmistha. “Assessment of putative risk factors in the development of Diabetic Retinopathy in Wales.” 2016. Web. 10 Apr 2021.

Vancouver:

Roy Chowdhury S. Assessment of putative risk factors in the development of Diabetic Retinopathy in Wales. [Internet] [Doctoral dissertation]. Cardiff University; 2016. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/101021/.

Council of Science Editors:

Roy Chowdhury S. Assessment of putative risk factors in the development of Diabetic Retinopathy in Wales. [Doctoral Dissertation]. Cardiff University; 2016. Available from: http://orca.cf.ac.uk/101021/

7. Jones, Christopher T. The evaluation and development of a retinal imaging densitometer.

Degree: PhD, 2017, Cardiff University

URL: http://orca.cf.ac.uk/111545/

► The research described in this thesis presents the development and evaluation of a prototype multispectral, imaging densitometer. Ultimately, the aim was to develop a method… (more)

Subjects/Keywords: RE Ophthalmology

10 more images…

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APA (6^th Edition):

Jones, C. T. (2017). The evaluation and development of a retinal imaging densitometer. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/111545/

Chicago Manual of Style (16^th Edition):

Jones, Christopher T. “The evaluation and development of a retinal imaging densitometer.” 2017. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/111545/.

MLA Handbook (7^th Edition):

Jones, Christopher T. “The evaluation and development of a retinal imaging densitometer.” 2017. Web. 10 Apr 2021.

Vancouver:

Jones CT. The evaluation and development of a retinal imaging densitometer. [Internet] [Doctoral dissertation]. Cardiff University; 2017. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/111545/.

Council of Science Editors:

Jones CT. The evaluation and development of a retinal imaging densitometer. [Doctoral Dissertation]. Cardiff University; 2017. Available from: http://orca.cf.ac.uk/111545/

Cardiff University

8. Davies, Ruth. The role of sIL-6R mediated trans-signaling in cardiovascular morbidity in Rheumatoid Arthritis.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/113095/

► Cardiovascular mortality in patients with RA is 50% higher than the general population. Although well established that the incidence of CVD is increased, the precise… (more)

▼ Cardiovascular mortality in patients with RA is 50% higher than the general population. Although well established that the incidence of CVD is increased, the precise cause is unclear. There is increasing recognition that systemic inflammation is a major driver of increased CV risk. IL-6 is implicated in CVD in the general population but its role in CVD in RA is undefined. Of the two modes of IL-6 signaling, evidence demonstrates that trans-signaling is pro-inflammatory whereas classical signaling has regenerative or anti-inflammatory effects. The aim of this thesis is to examine the role of IL-6 trans-signaling in CVD in RA by experimental and translational studies. Methods Myography was used to determine the effect of IL-6 trans-signaling blockade, using sgp130Fc, on aortic constriction in mice with CIA. Serum CCL2 and VCAM-1 were measured. The effect of IL-6 trans-signaling, using Hyper-IL-6, on atherosclerotic plaque size and fibrous cap thickness was assessed in ApoE-/- mice. Arterial and plaque VCAM-1 expression was assessed. The relationship between sIL-6R-regulated CVD Candidate Proteins (SCCPs) and CVD in established RA was investigated in a cross-sectional study. An observational longitudinal study investigated whether SCCPs were associated with presence and progression of subclinical atherosclerosis in early RA, using carotid ultrasound to measure CIMT. Results Sgp130Fc reduced arthritis severity and restored vascular dysfunction in CIA. This was associated with reduced serum CCL2 and VCAM-1. In ApoE-/- mice, Hyper-IL-6 increased plaque size and VCAM-1 expression in the brachiocephalic artery. In established RA, VCAM-1 correlated with disease activity and CV risk. In early RA, baseline RA disease activity was associated with CIMT change at 6 months. Patients that were ‘rapid progressors’, in terms of CIMT change at 12 months, had higher baseline VCAM-1, HbA1c, total cholesterol:HDL ratio and LDL cholesterol. Discussion IL-6 trans-signaling appears to play a pivotal role in vascular dysfunction and atherosclerosis in mouse models. In early RA, proteins regulated by IL-6 trans-signaling are associated with progression of subclinical atherosclerosis. Inflammation from RA onset in CVD susceptible individuals may accelerate atherosclerosis. Findings suggest that IL-6 trans-signaling blockade may be beneficial to RA patients, and perhaps for atherosclerosis in the general population.

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APA (6^th Edition):

Davies, R. (2018). The role of sIL-6R mediated trans-signaling in cardiovascular morbidity in Rheumatoid Arthritis. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/113095/

Chicago Manual of Style (16^th Edition):

Davies, Ruth. “The role of sIL-6R mediated trans-signaling in cardiovascular morbidity in Rheumatoid Arthritis.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/113095/.

MLA Handbook (7^th Edition):

Davies, Ruth. “The role of sIL-6R mediated trans-signaling in cardiovascular morbidity in Rheumatoid Arthritis.” 2018. Web. 10 Apr 2021.

Vancouver:

Davies R. The role of sIL-6R mediated trans-signaling in cardiovascular morbidity in Rheumatoid Arthritis. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/113095/.

Council of Science Editors:

Davies R. The role of sIL-6R mediated trans-signaling in cardiovascular morbidity in Rheumatoid Arthritis. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/113095/

Cardiff University

9. Werrell, Jessica Mary. Characterisation and preparation of superconducting diamond films for the production of NEMS and SQUIDS.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/121201/

► Boron doped nanocrystalline diamond has intrinsic properties (namely a high young’s modulus to density ratio) that make it an appealing material for the construction of… (more)

Subjects/Keywords: QC Physics

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APA (6^th Edition):

Werrell, J. M. (2018). Characterisation and preparation of superconducting diamond films for the production of NEMS and SQUIDS. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/121201/

Chicago Manual of Style (16^th Edition):

Werrell, Jessica Mary. “Characterisation and preparation of superconducting diamond films for the production of NEMS and SQUIDS.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/121201/.

MLA Handbook (7^th Edition):

Werrell, Jessica Mary. “Characterisation and preparation of superconducting diamond films for the production of NEMS and SQUIDS.” 2018. Web. 10 Apr 2021.

Vancouver:

Werrell JM. Characterisation and preparation of superconducting diamond films for the production of NEMS and SQUIDS. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/121201/.

Council of Science Editors:

Werrell JM. Characterisation and preparation of superconducting diamond films for the production of NEMS and SQUIDS. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/121201/

Cardiff University

10. Mehler, David. Clinical applications of real-time FMRI neurofeedback training – premises, promises, and pitfalls.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/117027/

► Neurofeedback training represents a form of biofeedback training with a history of over 50 years. During neurofeedback training participants aim to gain control over a… (more)

▼ Neurofeedback training represents a form of biofeedback training with a history of over 50 years. During neurofeedback training participants aim to gain control over a feedback signal that represents the activity of a brain region or network of interest. As such, it holds promise for clinical translation as an add-on treatment for psychiatric and neurological conditions. Yet, currently available evidence for its therapeutic efficacy remains limited. Originally provided based on cortical signals measured with electroencephalography (EEG), methodological developments have allowed providing neurofeedback based on (cortical and subcortical) brain signals acquired from functional magnetic resonance imaging (fMRI). The aim of this thesis was to test the feasibility and clinical efficacy of fMRI neurofeedback (fMRI-NF) training in a psychiatric population and to develop protocols that allow translating the technique to motor rehabilitation. Specifically, this thesis summarises the clinical and neuroimaging results from a randomised controlled trial conducted in patients suffering from depression. Depression represents a leading cause of disability in adults and epidemiological data indicates that up to one third of patients remain depressed after treatment. Another focus was the development of a motor imagery-based fMRI-NF protocol in healthy participants. This work has informed a proof-of-concept study for motor rehabilitation in stroke survivors, for which the methodology was preregistered on a public platform before data collection started to increase transparency. The thesis aims to address problematic research practices that have been attributed to the replication crisis in many areas of science, including a clear separation of planned and exploratory hypotheses and the use and adaptation of alternative statistical methods. A review chapter discusses potential electrophysiological target signatures for EEG-NF to improve motor symptoms in Parkinson’s disease patients. The thesis concludes with a discussion of current premises, promises, and pitfalls in clinical applications of neurofeedback training and considerations for clinical trials development.

Subjects/Keywords: BF Psychology

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APA (6^th Edition):

Mehler, D. (2018). Clinical applications of real-time FMRI neurofeedback training – premises, promises, and pitfalls. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/117027/

Chicago Manual of Style (16^th Edition):

Mehler, David. “Clinical applications of real-time FMRI neurofeedback training – premises, promises, and pitfalls.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/117027/.

MLA Handbook (7^th Edition):

Mehler, David. “Clinical applications of real-time FMRI neurofeedback training – premises, promises, and pitfalls.” 2018. Web. 10 Apr 2021.

Vancouver:

Mehler D. Clinical applications of real-time FMRI neurofeedback training – premises, promises, and pitfalls. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/117027/.

Council of Science Editors:

Mehler D. Clinical applications of real-time FMRI neurofeedback training – premises, promises, and pitfalls. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/117027/

Cardiff University

11. Stott, Matthew. Activation and inactivation of the complement anaphylatoxins during chronic neutrophilic inflammation of the cystic fibrosis airway.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/118523/

► Cystic fibrosis (CF) is a fatal genetic disease that affects 1/2500 people in the UK. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause… (more)

▼ Cystic fibrosis (CF) is a fatal genetic disease that affects 1/2500 people in the UK. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause dehydration of mucosal membranes, leading to mucus obstruction of the small airways. The CF lungs are susceptible to recurrent infection promoting chronic neutrophilic inflammation. Neutrophils recruited to the CF lungs become dysfunctional and are ineffective at clearing pathogens, perpetuating inflammation. Neutrophil serine proteases (NSPs) released by neutrophils collaterally remodel the airway, reducing lung function and causing mortality. The complement anaphylatoxins (C5a and C3a) are important mediators of inflammation. C5a and C3a are chemotactic for monocytes and granulocytes, they also stimulate degranulation and the generation of reactive oxygen species (ROS). C5a is particularly potent towards neutrophils and is critical for orchestrating their response towards pathogens. C5a and C3a are elevated in the CF airway. Furthermore, in addition to complement activation these anaphylatoxins can be generated by non-complement proteases including NSPs. The mechanisms by which C5a and C3a promote chronic neutrophilic inflammation in the CF airways are not fully understood. In my study I show that C5a and C3a correlate with markers of neutrophilic inflammation (neutrophil count and CXCL8) in bronchoalveolar lavage (BAL) fluid from paediatric CF patients. I further characterise the generation of functionally active C5a-like and C3a-like forms by NSPs. Moreover, I demonstrate that atypical C5a production by NSPs cannot be prevented by therapeutic complement inhibitors. I show for the first time that NSP-generated C5a-like fragments are resistant to inactivation by carboxypeptidase B, an important regulator of C5a activity. I also further characterise the interaction between C5a and soluble glycosaminoglycans (GAGs), these are abundant during chronic neutrophilic inflammation of the CF airway. Additionally, I show that GAG interaction influences C5a activity. In conclusion, the CF airway environment modifies C5a function; these mechanisms could promote chronic neutrophilic inflammation.

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APA (6^th Edition):

Stott, M. (2018). Activation and inactivation of the complement anaphylatoxins during chronic neutrophilic inflammation of the cystic fibrosis airway. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/118523/

Chicago Manual of Style (16^th Edition):

Stott, Matthew. “Activation and inactivation of the complement anaphylatoxins during chronic neutrophilic inflammation of the cystic fibrosis airway.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/118523/.

MLA Handbook (7^th Edition):

Stott, Matthew. “Activation and inactivation of the complement anaphylatoxins during chronic neutrophilic inflammation of the cystic fibrosis airway.” 2018. Web. 10 Apr 2021.

Vancouver:

Stott M. Activation and inactivation of the complement anaphylatoxins during chronic neutrophilic inflammation of the cystic fibrosis airway. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/118523/.

Council of Science Editors:

Stott M. Activation and inactivation of the complement anaphylatoxins during chronic neutrophilic inflammation of the cystic fibrosis airway. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/118523/

Cardiff University

12. Flack, Timothy. The development of novel techniques to analyse particle diffusion in battery materials: The case of lithiated and sodiated olivine phosphates.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/118525/

► Energy storage technologies, in particular second-generation rechargeable batteries, are instrumental in addressing the current global demand for clean and sustainable energy. The progress of portable… (more)

▼ Energy storage technologies, in particular second-generation rechargeable batteries, are instrumental in addressing the current global demand for clean and sustainable energy. The progress of portable electronics, electric and hybrid-electric vehicles and large-scale grid storage depends on the available technology of rechargeable batteries. Innovation requires a fundamental atomicscale understanding of the properties of the constituent battery materials. Critical to a battery’s performance is the electronic and ionic conductivity of the material. Poor ion transport leads to poor rate capability, practical capacity and cyclability. The current research into particle diffusion is predominantly based on single-particle potential energy calculations. Such an approach neglects not only the entropic contribution to diffusion, but the contributions of the collective dynamics which are present in a many particle configuration Using two novel, state-of-the-art enhanced sampling techniques, the ‘Shooter’ method’ and metadynamics, particle diffusion within a many particle system is analysed. The ‘Shooter’ method is able to connect single particle translocation events into a general particle diffusion mechanism and elucidate diffusion pathways that are otherwise disregarded by single-particle potential energy calculations. This is achieved under consideration of all degrees of freedom, explicitly allowing for local structure changes and lattice dynamics. The application of metadynamics simulations to battery materials is shown for the first time. Using novel collective variables to distinguish between nondiffusive and diffusive regimes, the free energy barrier for diffusion is calculated, therefore considering the entropic contribution. The free energy surface is also reconstructed, highlighting the complex nature of particle diffusion with the olivine phosphates. Using the two novel approaches, the short-time evolution of disorder within the system can be followed and allows for the characterisation of highly complex and correlated translocation events. Additionally,rare events such as twodimensional diffusion and the formation of antisite defects are observed on nominal simulation timeframes. In summary, several novel computational approaches to analysing particle diffusion within battery materials have been developed.

Subjects/Keywords: QD Chemistry

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APA (6^th Edition):

Flack, T. (2018). The development of novel techniques to analyse particle diffusion in battery materials: The case of lithiated and sodiated olivine phosphates. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/118525/

Chicago Manual of Style (16^th Edition):

Flack, Timothy. “The development of novel techniques to analyse particle diffusion in battery materials: The case of lithiated and sodiated olivine phosphates.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/118525/.

MLA Handbook (7^th Edition):

Flack, Timothy. “The development of novel techniques to analyse particle diffusion in battery materials: The case of lithiated and sodiated olivine phosphates.” 2018. Web. 10 Apr 2021.

Vancouver:

Flack T. The development of novel techniques to analyse particle diffusion in battery materials: The case of lithiated and sodiated olivine phosphates. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/118525/.

Council of Science Editors:

Flack T. The development of novel techniques to analyse particle diffusion in battery materials: The case of lithiated and sodiated olivine phosphates. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/118525/

Cardiff University

13. Cameron, Darren. Gene regulation in microglia and genetic risk for complex brain disorders.

Degree: PhD, 2019, Cardiff University

URL: http://orca.cf.ac.uk/128465/

► In recent years, genome wide association studies (GWAS) have established that common genetic variation plays an important role in complex brain disorders, such as autism… (more)

▼ In recent years, genome wide association studies (GWAS) have established that common genetic variation plays an important role in complex brain disorders, such as autism spectrum disorder, schizophrenia and Alzheimer’s disease. However, as the vast majority of GWAS risk loci are located in poorly characterised non-coding regions, interpretation of GWAS data is difficult. As very few associations can be attributed to effects on protein-coding sequence, the majority of common risk loci for complex brain disorders are believed to operate through effects on gene regulation. In order to elucidate genetic risk mechanisms for complex brain disorders, it is important to establish in which cell types these risk loci are operating. Microglia are the primary immune cell of the central nervous system and are important regulators of brain function throughout life. As such, there has been growing interest in the potential role of microglia in brain disorders. One means of interpreting the function of the non-coding genome in a cell of interest is to measure the cell’s chromatin landscape. For example, the assay for transposase accessible chromatin with sequencing (ATAC-seq) maps regions of ‘open’ chromatin, which have the potential to regulate gene expression through binding of transcription factors. In this thesis, I use ATAC-seq to map open chromatin in adult ex vivo microglia, 2nd trimester foetal microglia, and in vitro human cell models of microglia. I then integrate this with complex brain disorder GWAS data to investigate whether gene regulatory processes in human microglia contribute to genetic risk for complex brain disorders. I find evidence that risk variants for late onset Alzheimer’s disease, autism spectrum disorder, bipolar disorder, major depressive disorder and schizophrenia are enriched within regulatory regions utilised by foetal and / or adult microglia, suggesting a primary role for this cell type in these conditions. Using the electrophoretic mobility shift assay, I further show that two single nucleotide polymorphisms associated with Alzheimer’s disease, and within regions of open chromatin in adult microglia, alter binding of protein from microglial nuclei.

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APA (6^th Edition):

Cameron, D. (2019). Gene regulation in microglia and genetic risk for complex brain disorders. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/128465/

Chicago Manual of Style (16^th Edition):

Cameron, Darren. “Gene regulation in microglia and genetic risk for complex brain disorders.” 2019. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/128465/.

MLA Handbook (7^th Edition):

Cameron, Darren. “Gene regulation in microglia and genetic risk for complex brain disorders.” 2019. Web. 10 Apr 2021.

Vancouver:

Cameron D. Gene regulation in microglia and genetic risk for complex brain disorders. [Internet] [Doctoral dissertation]. Cardiff University; 2019. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/128465/.

Council of Science Editors:

Cameron D. Gene regulation in microglia and genetic risk for complex brain disorders. [Doctoral Dissertation]. Cardiff University; 2019. Available from: http://orca.cf.ac.uk/128465/

Cardiff University

14. Al-Braiki, Nasiha. Exploring how NICU nurses in Oman experience and understand neonatal pain and its management.

Degree: PhD, 2019, Cardiff University

URL: http://orca.cf.ac.uk/128563/

► Minimizing infant pain has become a significant concern worldwide. However, in Oman there are no standardized, evidence-based (EB) guidelines of care for achieving this goal.… (more)

▼ Minimizing infant pain has become a significant concern worldwide. However, in Oman there are no standardized, evidence-based (EB) guidelines of care for achieving this goal. Pain management strategies and protocols vary considerably among neonatal health care professionals and between neonatal intensive care units (NICU) and are not evidence based. Moreover, there are no neonatal pain assessment tools to help staff detect and learn how to manage pain. This study used an ethnographic approach to explore how nurses approach and interact with babies being cared for in a neonatal intensive care unit in Oman, with a particular focus on pain. There have been very few qualitative studies of NICU nursing, and no studies have been found that focused on neonatal pain. An ethnographic approach enabled me to explore how organizational culture informs the management of neonatal pain; for example, how pain was perceived, assessed, and managed by nurses, the barriers or challenges the nursing staff face from implementing appropriate strategies, the impact of NICU environment on how nurses interact with babies. The study’s primary aim was to explore the experiences and understanding of neonatal pain and its management among NICU Nurses caring for babies who have been admitted to NICU in ‘Hope’ Hospital in Oman. Data collection took place over four months. A range of qualitative data collection methods were used to answer the research questions (observational field work and interviews). Following a period of 6 weeks general observation of nurses’ work in NICU, semi-structured interviews were conducted with a purposive sample of 20 Omani and Non- Omani Neonatal Nurses until data saturation was reached. The sample included nurses with different levels of training, to explore whether, how and why nurses differ in their behaviours, approaches and beliefs regarding pain and pain management. The immediate outcomes of the study were to achieve a better understanding of how neonatal pain was assessed and managed by nurses in NICU, how this was influenced by organizational culture, and to gain insight into nurses’ understandings of baby’s pain and how it was managed. Four themes emerged from the research data collection, the NICU environment, complexity of organisational culture, lack of professional autonomy and inconsistency of pain practice. In the first theme, the NICU environment has particular environmental stressors (crowded, busy, noisy, and handling). It appeared that the environment is one of the major challenges for nursing staff in their practice and interaction with the babies. The majority of nurses reported that these stressors affect babies' development and cause the NICU nurses to experience stress. In the second theme, the organisational culture appear to have an impact on nurses' performance, as the culture was experienced as unhealthy, blaming and unsupportive to the nursing staff. Due to that, all the nursing staff revealed that they were overwhelmed, depressed and unsatisfied. Lack of training was a major…

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APA (6^th Edition):

Al-Braiki, N. (2019). Exploring how NICU nurses in Oman experience and understand neonatal pain and its management. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/128563/

Chicago Manual of Style (16^th Edition):

Al-Braiki, Nasiha. “Exploring how NICU nurses in Oman experience and understand neonatal pain and its management.” 2019. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/128563/.

MLA Handbook (7^th Edition):

Al-Braiki, Nasiha. “Exploring how NICU nurses in Oman experience and understand neonatal pain and its management.” 2019. Web. 10 Apr 2021.

Vancouver:

Al-Braiki N. Exploring how NICU nurses in Oman experience and understand neonatal pain and its management. [Internet] [Doctoral dissertation]. Cardiff University; 2019. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/128563/.

Council of Science Editors:

Al-Braiki N. Exploring how NICU nurses in Oman experience and understand neonatal pain and its management. [Doctoral Dissertation]. Cardiff University; 2019. Available from: http://orca.cf.ac.uk/128563/

Cardiff University

15. An, Haiyan. Molecular pathomechanisms of Amyotrophic Lateral Sclerosis caused by FUS mutations.

Degree: PhD, 2019, Cardiff University

URL: http://orca.cf.ac.uk/128572/

► Amyotrophic lateral sclerosis (ALS) is the most common type of motor neuron disease affecting both upper and lower motor neurons. About 10% of ALS cases… (more)

▼ Amyotrophic lateral sclerosis (ALS) is the most common type of motor neuron disease affecting both upper and lower motor neurons. About 10% of ALS cases run in families with known genetic background, and mutations in the Fused in Sarcoma (FUS) gene are responsible for about 5% of the fALS cases (ALS-FUS). Despite normal FUS is a predominantly nuclear protein, mutant FUS is found to accumulate and aggregate in the cytoplasm of affected neurons and glial cells in ALS-FUS. It is generally believed that mutations are the primary cause of FUS protein mislocalisation, and additional stresses are required to trigger the formation of insoluble FUS aggregates (FUSopathy). However, no clear consensus has been achieved on many important questions. For instance, what are the consequences of FUS protein mutation for its nuclear function and how do they contribute to ALS-FUS development? What is the nature of the stress that promotes the massive protein accumulation and inclusion formation in the cytoplasm? This thesis attempts to address these questions using novel cellular models with targeted modifications of the FUS gene. It is demonstrated that the presence of endogenous mutant FUS protein in the nucleus causes hyper-assembly of structurally and functionally abnormal paraspeckles - nuclear bodies assembled on the long non-coding RNA called Nuclear Paraspeckle Assembly Transcript 1 (NEAT1). Dysfunctional paraspeckles together with accumulation of NEAT1 outside paraspeckles might contribute to the disease severity. Stresses capable of triggering cytoplasmic FUS aggregates are also investigated, and as a result, antiviral immune response has emerged as a potent stress promoting formation of persistent cytoplasmic FUS-positive assemblies. In addition, type I interferon expressed during antiviral response is found to cause FUS protein accumulation by increasing FUS mRNA stability. I propose a multi-step model where antiviral immune response serves as the "second hit" provoking FUSopathy. This thesis offers novel insights into the cellular and molecular events leading to the initiation and progression of ALS-FUS, which should help inform the development of therapeutic strategies in the future.

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APA (6^th Edition):

An, H. (2019). Molecular pathomechanisms of Amyotrophic Lateral Sclerosis caused by FUS mutations. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/128572/

Chicago Manual of Style (16^th Edition):

An, Haiyan. “Molecular pathomechanisms of Amyotrophic Lateral Sclerosis caused by FUS mutations.” 2019. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/128572/.

MLA Handbook (7^th Edition):

An, Haiyan. “Molecular pathomechanisms of Amyotrophic Lateral Sclerosis caused by FUS mutations.” 2019. Web. 10 Apr 2021.

Vancouver:

An H. Molecular pathomechanisms of Amyotrophic Lateral Sclerosis caused by FUS mutations. [Internet] [Doctoral dissertation]. Cardiff University; 2019. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/128572/.

Council of Science Editors:

An H. Molecular pathomechanisms of Amyotrophic Lateral Sclerosis caused by FUS mutations. [Doctoral Dissertation]. Cardiff University; 2019. Available from: http://orca.cf.ac.uk/128572/

Cardiff University

16. Tuson, Mark. Understanding the impact of social networks on the spread of obesity.

Degree: PhD, 2019, Cardiff University

URL: http://orca.cf.ac.uk/128597/

► The spread of obesity through social networks has been well documented most notably by Christakis and Fowler in 2007. In this research we sought to… (more)

Subjects/Keywords: QA Mathematics

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APA (6^th Edition):

Tuson, M. (2019). Understanding the impact of social networks on the spread of obesity. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/128597/

Chicago Manual of Style (16^th Edition):

Tuson, Mark. “Understanding the impact of social networks on the spread of obesity.” 2019. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/128597/.

MLA Handbook (7^th Edition):

Tuson, Mark. “Understanding the impact of social networks on the spread of obesity.” 2019. Web. 10 Apr 2021.

Vancouver:

Tuson M. Understanding the impact of social networks on the spread of obesity. [Internet] [Doctoral dissertation]. Cardiff University; 2019. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/128597/.

Council of Science Editors:

Tuson M. Understanding the impact of social networks on the spread of obesity. [Doctoral Dissertation]. Cardiff University; 2019. Available from: http://orca.cf.ac.uk/128597/

Cardiff University

17. Armstrong, Robert. Partial oxidative upgrading of ethane with Fe- and Cu-ZSM-5 catalysts.

Degree: PhD, 2013, Cardiff University

URL: http://orca.cf.ac.uk/59701/

► The selective oxidation of lower alkane components of natural gas, such as ethane, to partial oxygenates remains a major challenge for both industry and academia.… (more)

▼ The selective oxidation of lower alkane components of natural gas, such as ethane, to partial oxygenates remains a major challenge for both industry and academia. At present 60% of industry’s 7.8 Mt annual acetic acid demand is met through the carbonylation of methane, the operation of which is highly energy intensive, leads to formation of corrosive iodide by-products and requires high pressures of CO. Meanwhile ethene, a feedstock of great industrial importance, is produced via steam cracking of alkanes such as ethane, a process which is typically operated at > 800 °C and accounts for ca. 40% of the petrochemical industry’s annual energy consumption. The development of an atom efficient, low temperature, environmentally benign process for the direct conversion of ethane to either of these molecules would circumvent the need for current practices and thereby represent an important milestone in the valorisation of natural gas. The heterogeneous catalyst system explored in this thesis is based upon zeolite (ZSM-5) catalysts, which may be modified via post synthesis deposition of either or both of iron and copper and are shown to selectively transform ethane to a variety of higher value products including but not limited to ethanol, acetaldehyde, acetic acid and ethene under mild, environmentally benign conditions (H2O2 as oxidant, water as solvent, temperatures of < 90 °C). C-C scission of C2 products led to formation of carbon centred radicals and yielded C1 products including methylhydroperoxide, methanol and formic acid, whilst deep oxidation yielded CO2, typically at selectivities of < 5%. The method by which catalysts were prepared was shown to impact significantly upon catalyst performance, with chemical vapour impregnation, a novel vapour deposition technique being shown to yield highly active catalysts. Investigations of reaction conditions such as ethane pressure, ethane partial pressure, temperature, oxidant concentration and catalyst mass [Chapter 1] III were conducted in a batch reaction system. All parameters were found to impact significantly upon both catalytic activity and product distributions allowing for directed selectivity to either ethanol or acetic acid as major product. Through extensive mechanistic studies, it was shown that a complex reaction scheme operates with these catalysts, which results in the primary C2 products ethanol, ethylhydroperoxide and ethene. Of these the former two were shown to undergo consecutive oxidation to acetaldehyde and acetic acid, whilst ethene was shown to react under test conditions to yield acetic acid. Additionally, upon deposition of Cu2+ onto ZSM-5 catalysts ethene was shown to become the major reaction product, with selectivities of 45.5% at 1.15% conversion. Following development under batch reaction conditions, the ZSM-5 catalysts were then applied under a continuous flow regime through co-feeding of an aqueous hydrogen peroxide solution and mixed ethane/ argon feed through a custom built fixed bed trickle bed reactor system. Through optimisation of…

Subjects/Keywords: QD Chemistry

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APA (6^th Edition):

Armstrong, R. (2013). Partial oxidative upgrading of ethane with Fe- and Cu-ZSM-5 catalysts. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/59701/

Chicago Manual of Style (16^th Edition):

Armstrong, Robert. “Partial oxidative upgrading of ethane with Fe- and Cu-ZSM-5 catalysts.” 2013. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/59701/.

MLA Handbook (7^th Edition):

Armstrong, Robert. “Partial oxidative upgrading of ethane with Fe- and Cu-ZSM-5 catalysts.” 2013. Web. 10 Apr 2021.

Vancouver:

Armstrong R. Partial oxidative upgrading of ethane with Fe- and Cu-ZSM-5 catalysts. [Internet] [Doctoral dissertation]. Cardiff University; 2013. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/59701/.

Council of Science Editors:

Armstrong R. Partial oxidative upgrading of ethane with Fe- and Cu-ZSM-5 catalysts. [Doctoral Dissertation]. Cardiff University; 2013. Available from: http://orca.cf.ac.uk/59701/

Cardiff University

18. Han, Catherine Paula. Reimagining the Brontës: (post)feminist middlebrow adaptations and representations of feminine creative genius, 1996-2011.

Degree: PhD, 2015, Cardiff University

URL: http://orca.cf.ac.uk/83347/

► Investigating conceptualisations of the feminine creative imagination, this thesis examines representations of the Brontës and adaptations of their novels released between 1996 and 2011. I… (more)

▼ Investigating conceptualisations of the feminine creative imagination, this thesis examines representations of the Brontës and adaptations of their novels released between 1996 and 2011. I focus on portrayals of Charlotte and Anne Brontë alongside reworkings of Jane Eyre (1847) and The Tenant of Wildfell Hall (1848) in various media. Contributing to existing research on the cultural afterlives of the Brontës and their novels, I position the works discussed within contemporary middlebrow culture whilst considering the influence of feminism. The Introduction discusses the gendering of creative genius before identifying the tensions between critical, middlebrow and popular discourses’ conceptualisations of the Brontës’ imaginations. Thereafter, the first chapter proposes the contemporary usefulness and considers the gendering of the concept of the middlebrow. I demonstrate that middlebrow culture is fascinated by the Brontës’ lives, art and feminine creative imaginations. To further this argument, the second chapter analyses neo-Victorian novels’ engagement with Charlotte Brontë’s life, art and creativity. I illustrate that these works draw from second-wave feminist criticism on Jane Eyre and belong to a tradition of middlebrow feminine writing about the Brontës. The third chapter also examines representations of feminine creativity and discusses how screen adaptations portray the artistry of Jane Eyre’s heroine. Additionally, the legacies of second-wave feminism in a wider postfeminist cultural context are explored. In the fourth chapter, the thesis turns to analyse the cultural dissemination and reputations of Anne Brontë and The Tenant of Wildfell Hall. I delineate how middlebrow culture has rediscovered the youngest Brontë, her novel and her feminism. Ultimately, this thesis suggests that the works examined indicate middlebrow culture’s efforts to engage with feminism through the feminine creative imagination. Yet these works expose a prevailing tension in feminism between the status of the individual and the collective.

Subjects/Keywords: PR English literature

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APA (6^th Edition):

Han, C. P. (2015). Reimagining the Brontës: (post)feminist middlebrow adaptations and representations of feminine creative genius, 1996-2011. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/83347/

Chicago Manual of Style (16^th Edition):

Han, Catherine Paula. “Reimagining the Brontës: (post)feminist middlebrow adaptations and representations of feminine creative genius, 1996-2011.” 2015. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/83347/.

MLA Handbook (7^th Edition):

Han, Catherine Paula. “Reimagining the Brontës: (post)feminist middlebrow adaptations and representations of feminine creative genius, 1996-2011.” 2015. Web. 10 Apr 2021.

Vancouver:

Han CP. Reimagining the Brontës: (post)feminist middlebrow adaptations and representations of feminine creative genius, 1996-2011. [Internet] [Doctoral dissertation]. Cardiff University; 2015. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/83347/.

Council of Science Editors:

Han CP. Reimagining the Brontës: (post)feminist middlebrow adaptations and representations of feminine creative genius, 1996-2011. [Doctoral Dissertation]. Cardiff University; 2015. Available from: http://orca.cf.ac.uk/83347/

Cardiff University

19. Letchford, Robert. A study of functional recovery following anterior cruciate ligament reconstruction.

Degree: PhD, 2015, Cardiff University

URL: http://orca.cf.ac.uk/91571/

► Introduction Anterior cruciate ligament reconstruction (ACLR) and rehabilitation is an accepted intervention for non-coping ACL injured subjects. There is an expectation from ACL injured subjects… (more)

▼ Introduction Anterior cruciate ligament reconstruction (ACLR) and rehabilitation is an accepted intervention for non-coping ACL injured subjects. There is an expectation from ACL injured subjects and the international clinical community that ACLR should enable recovery to pre-injury knee function, activity performance and participation. However, few studies use comprehensive methods to assess this expectation and the reality seems to be a highly variable and often incomplete recovery that is difficult to predict. Improved understanding of recovery of these subjects may identify targets for novel rehabilitation interventions that improve outcomes. Methods Prospective longitudinal data were collected from 74 ACL injured subjects before surgery and on 5 occasions during the first year following ACLR. Data from a matched healthy group (n=61) were used to define healthy normative values. Outcome measures included; Structure (arthroscopic and MRI findings), Function (IKDC SKF, Lysholm, VAS pain), Activity (2D digital video motion analysis of performance and strategy variables during gait, single leg squat and hop for distance) and Participation (Tegner). Group differences and recovery were assessed with inferential statistics; regression methods identified predictors of recovery. Results These ACL injured subjects were highly symptomatic non-copers with a prolonged period between injury and surgery. There were statistically and clinically significant deficits from healthy in all outcome measures before surgery, which improved one year following ACLR; however the majority failed to fully recover. Bilateral deficits in activity performance and strategy were identified during all three functional activities. Recovery at one year was not predicted by any of the outcome measures in the pre or post-operative period. However, activity performance at one year was predicted by pre-operative and early post-operative gait velocity and squat depth. Conclusions Whilst these highly symptomatic non-coping ACLD subjects benefited from ACLR and rehabilitation, expectations of full recovery by one year proved unrealistic for most. Pre-operative deficits appear to be too large for current interventions to overcome. Early diagnostics, classification and intervention should be considered to reduce pre-operative impairments. Bilateral and hierarchical deficits in activities suggest that further development of task oriented rehabilitation strategies should be built on biomechanical and motor control / learning theories to improve outcomes. Utilising technology to facilitate greater engagement in rehabilitation and increasing frequency and intensity of rehabilitation interventions should be considered. Further development of clinically applicable methods to measure and provide real time feedback on both performance and strategy in functional activities are therefore required.

Subjects/Keywords: R Medicine (General)

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APA (6^th Edition):

Letchford, R. (2015). A study of functional recovery following anterior cruciate ligament reconstruction. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/91571/

Chicago Manual of Style (16^th Edition):

Letchford, Robert. “A study of functional recovery following anterior cruciate ligament reconstruction.” 2015. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/91571/.

MLA Handbook (7^th Edition):

Letchford, Robert. “A study of functional recovery following anterior cruciate ligament reconstruction.” 2015. Web. 10 Apr 2021.

Vancouver:

Letchford R. A study of functional recovery following anterior cruciate ligament reconstruction. [Internet] [Doctoral dissertation]. Cardiff University; 2015. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/91571/.

Council of Science Editors:

Letchford R. A study of functional recovery following anterior cruciate ligament reconstruction. [Doctoral Dissertation]. Cardiff University; 2015. Available from: http://orca.cf.ac.uk/91571/

Cardiff University

20. Vasalauskaite, Asta. Visual function in human and experimental glaucoma.

Degree: PhD, 2016, Cardiff University

URL: http://orca.cf.ac.uk/98604/

► Injury to optic nerve (ON) axons plays a major role in glaucoma progression. ON crush is an established model of axonal injury which results in… (more)

Subjects/Keywords: RE Ophthalmology

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APA (6^th Edition):

Vasalauskaite, A. (2016). Visual function in human and experimental glaucoma. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/98604/

Chicago Manual of Style (16^th Edition):

Vasalauskaite, Asta. “Visual function in human and experimental glaucoma.” 2016. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/98604/.

MLA Handbook (7^th Edition):

Vasalauskaite, Asta. “Visual function in human and experimental glaucoma.” 2016. Web. 10 Apr 2021.

Vancouver:

Vasalauskaite A. Visual function in human and experimental glaucoma. [Internet] [Doctoral dissertation]. Cardiff University; 2016. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/98604/.

Council of Science Editors:

Vasalauskaite A. Visual function in human and experimental glaucoma. [Doctoral Dissertation]. Cardiff University; 2016. Available from: http://orca.cf.ac.uk/98604/

21. Routley, Bethany. Investigating resting-state functional connectivity in health and epilepsy using magnetonencephalography.

Degree: PhD, 2017, Cardiff University

URL: http://orca.cf.ac.uk/107113/

► It is now widely accepted that different areas of the brain are functionally connected even in the absence of explicit task demands, the so-called 'resting-state'.… (more)

Subjects/Keywords: BF Psychology

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APA (6^th Edition):

Routley, B. (2017). Investigating resting-state functional connectivity in health and epilepsy using magnetonencephalography. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/107113/

Chicago Manual of Style (16^th Edition):

Routley, Bethany. “Investigating resting-state functional connectivity in health and epilepsy using magnetonencephalography.” 2017. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/107113/.

MLA Handbook (7^th Edition):

Routley, Bethany. “Investigating resting-state functional connectivity in health and epilepsy using magnetonencephalography.” 2017. Web. 10 Apr 2021.

Vancouver:

Routley B. Investigating resting-state functional connectivity in health and epilepsy using magnetonencephalography. [Internet] [Doctoral dissertation]. Cardiff University; 2017. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/107113/.

Council of Science Editors:

Routley B. Investigating resting-state functional connectivity in health and epilepsy using magnetonencephalography. [Doctoral Dissertation]. Cardiff University; 2017. Available from: http://orca.cf.ac.uk/107113/

Cardiff University

22. Wang, Zeliang. Polynomial matrix eigenvalue decomposition techniques for multichannel signal processing.

Degree: PhD, 2017, Cardiff University

URL: http://orca.cf.ac.uk/108257/

► Polynomial eigenvalue decomposition (PEVD) is an extension of the eigenvalue decomposition (EVD) for para-Hermitian polynomial matrices, and it has been shown to be a powerful… (more)

▼ Polynomial eigenvalue decomposition (PEVD) is an extension of the eigenvalue decomposition (EVD) for para-Hermitian polynomial matrices, and it has been shown to be a powerful tool for broadband extensions of narrowband signal processing problems. In the context of broadband sensor arrays, the PEVD allows the para-Hermitian matrix that results from the calculation of a space-time covariance matrix of the convolutively mixed signals to be diagonalised. Once the matrix is diagonalised, not only can the correlation between different sensor signals be removed but the signal and noise subspaces can also be identified. This process is referred to as broadband subspace decomposition, and it plays a very important role in many areas that require signal separation techniques for multichannel convolutive mixtures, such as speech recognition, radar clutter suppression, underwater acoustics, etc. The multiple shift second order sequential best rotation (MS-SBR2) algorithm, built on the most established SBR2 algorithm, is proposed to compute the PEVD of para-Hermitian matrices. By annihilating multiple off-diagonal elements per iteration, the MS-SBR2 algorithm shows a potential advantage over its predecessor (SBR2) in terms of the computational speed. Furthermore, the MS-SBR2 algorithm permits us to minimise the order growth of polynomial matrices by shifting rows (or columns) in the same direction across iterations, which can potentially reduce the computational load of the algorithm. The effectiveness of the proposed MS-SBR2 algorithm is demonstrated by various para-Hermitian matrix examples, including randomly generated matrices with different sizes and matrices generated from source models with different dynamic ranges and relations between the sources’ power spectral densities. A worked example is presented to demonstrate how the MS-SBR2 algorithm can be used to strongly decorrelate a set of convolutively mixed signals. Furthermore, the performance metrics and computational complexity of MS-SBR2 are analysed and compared to other existing PEVD algorithms by means of numerical examples. Finally, two potential applications of theMS-SBR2 algorithm, includingmultichannel spectral factorisation and decoupling of broadband multiple-input multiple-output (MIMO) systems, are demonstrated in this dissertation.

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APA (6^th Edition):

Wang, Z. (2017). Polynomial matrix eigenvalue decomposition techniques for multichannel signal processing. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/108257/

Chicago Manual of Style (16^th Edition):

Wang, Zeliang. “Polynomial matrix eigenvalue decomposition techniques for multichannel signal processing.” 2017. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/108257/.

MLA Handbook (7^th Edition):

Wang, Zeliang. “Polynomial matrix eigenvalue decomposition techniques for multichannel signal processing.” 2017. Web. 10 Apr 2021.

Vancouver:

Wang Z. Polynomial matrix eigenvalue decomposition techniques for multichannel signal processing. [Internet] [Doctoral dissertation]. Cardiff University; 2017. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/108257/.

Council of Science Editors:

Wang Z. Polynomial matrix eigenvalue decomposition techniques for multichannel signal processing. [Doctoral Dissertation]. Cardiff University; 2017. Available from: http://orca.cf.ac.uk/108257/

Cardiff University

23. Rountree, Lindsay. Optimisation of perimetric stimuli for mapping changes in spatial summation in glaucoma.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/111180/

► Despite being considered the current reference standard for perimetric testing in glaucoma, standard automated perimetry has several cardinal limitations, including an unacceptably high test-retest variability,… (more)

▼ Despite being considered the current reference standard for perimetric testing in glaucoma, standard automated perimetry has several cardinal limitations, including an unacceptably high test-retest variability, which increases with increasing depth of defect, and a limited useable dynamic range, with test-retest variability spanning almost the entire instrument range in advanced glaucomatous damage. Prior studies have shown that spatial summation, the mechanism by which the visual system integrates light energy across the area of a stimulus, differs in disease, with an enlarged Ricco’s area (the limit of complete spatial summation) found in individuals with glaucoma. The aim of this work was to investigate whether a perimetric stimulus designed to exploit these changes in spatial summation would enable a greater signal/noise ratio (SNR) than that of the current standard stimulus, by directly measuring the displacement of the spatial summation function in glaucoma. Three stimulus forms were developed; one varying in area alone, one varying in both area and contrast simultaneously, and one varying in contrast alone, all operating within the local Ricco’s area. These novel stimuli were compared with the standard Goldmann III stimulus, in terms of disease signal, noise, and SNR. The experiments presented in this thesis indicate that a stimulus modulating in area alone may offer greater benefits for measuring glaucomatous changes in spatial summation in a clinical setting, in the form of a greater disease signal, more uniform response variability with depth of defect, and greater SNR, when compared with the standard Goldmann III stimulus. Additionally, there is some indication that this stimulus is more robust to the effects of intraocular straylight than the Goldmann III stimulus, although test-retest variability and robustness to optical defocus are largely similar. As this work represents the early investigations of this stimulus, further work is required to examine its translation into a clinical environment.

Subjects/Keywords: RE Ophthalmology

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APA (6^th Edition):

Rountree, L. (2018). Optimisation of perimetric stimuli for mapping changes in spatial summation in glaucoma. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/111180/

Chicago Manual of Style (16^th Edition):

Rountree, Lindsay. “Optimisation of perimetric stimuli for mapping changes in spatial summation in glaucoma.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/111180/.

MLA Handbook (7^th Edition):

Rountree, Lindsay. “Optimisation of perimetric stimuli for mapping changes in spatial summation in glaucoma.” 2018. Web. 10 Apr 2021.

Vancouver:

Rountree L. Optimisation of perimetric stimuli for mapping changes in spatial summation in glaucoma. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/111180/.

Council of Science Editors:

Rountree L. Optimisation of perimetric stimuli for mapping changes in spatial summation in glaucoma. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/111180/

24. Fry, Charlotte. Executive functions, creativity, and mental health in homeless young people: implications for housing outcome.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/111664/

► Background: Homeless young people represent one of the most vulnerable groups in society, yet little is known about cognition, and especially executive functioning, in this… (more)

▼ Background: Homeless young people represent one of the most vulnerable groups in society, yet little is known about cognition, and especially executive functioning, in this group. Executive functions (EFs), higher-order cognitive processes important for adaptation, have been identified as likely key contributors to the capacity to exit homelessness. However, most homeless young people have experienced multiple adversities, with potential implications for EF development. To address gaps in current knowledge, this thesis aimed to profile executive functions among homeless young people and compare the profile to housed young people. Associations between EFs and mental health, and relationships between EFs and short-term housing outcomes were also explored. Methods: Sixty-nine homeless young people (16-19 years) from a homelessness charity, and 37 age-matched housed young people from a college/sixth form participated. Computerised EF tasks spanned the domains of working memory, set shifting/flexibility, planning, impulsivity/risky decision making, selective attention/inhibition, creative thinking, and verbal fluency. Results: Homeless young people demonstrated worse performance than housed youth on several EF tasks, particularly working memory and impulsivity/risky decision making. No differences were found between the groups in creativity. Rates of anxiety were higher in the homeless group, but not depression. Working memory predicted progression into more independent accommodation, such that those with longer working memory spans were twice as likely to have progressed rather than maintained after six months. Anxiety and depression did not seem to moderate this effect. A minority of young people had negative housing outcomes and were profiled separately. Conclusion: Findings from this thesis suggest that EFs should not continue to be overlooked by researchers and services, as they can impact on a homeless young person’s ability to move towards independence. Emerging adulthood, as a sensitive period for EF development, is likely to represent an opportune time for intervention to improve the likelihood of positive housing outcomes in homeless young people.

Subjects/Keywords: BF Psychology

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APA (6^th Edition):

Fry, C. (2018). Executive functions, creativity, and mental health in homeless young people: implications for housing outcome. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/111664/

Chicago Manual of Style (16^th Edition):

Fry, Charlotte. “Executive functions, creativity, and mental health in homeless young people: implications for housing outcome.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/111664/.

MLA Handbook (7^th Edition):

Fry, Charlotte. “Executive functions, creativity, and mental health in homeless young people: implications for housing outcome.” 2018. Web. 10 Apr 2021.

Vancouver:

Fry C. Executive functions, creativity, and mental health in homeless young people: implications for housing outcome. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/111664/.

Council of Science Editors:

Fry C. Executive functions, creativity, and mental health in homeless young people: implications for housing outcome. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/111664/

Cardiff University

25. Moss, Joe. Anti-inflammatory actions of nutraceuticals: Novel emerging therapies for atherosclerosis?.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/111849/

► Background Cardiovascular disease (CVD)-related events such as myocardial infarction and stroke remain the world’s leading cause of death. The incidence of CVD-related events is expected… (more)

▼ Background Cardiovascular disease (CVD)-related events such as myocardial infarction and stroke remain the world’s leading cause of death. The incidence of CVD-related events is expected to rise in the future due to the increase in the global prevalence of obesity and diabetes, in addition to less economically developed countries adopting a western style diet. Atherosclerosis is a chronic inflammatory disease which is the underlying cause of CVD and characterised by the build-up of fatty deposits within the walls of medium and large arteries. Macrophages play critical roles during the pathogenesis of atherosclerosis, including the uptake of modified low-density lipoproteins to form foam cells. CardioWise is a dietary supplement developed by Cultech Limited which contains the anti-inflammatory compounds ω-3 PUFAs, flavanols and phytosterols. The aim of this project was to assess the cardiovascular protective effects of CardioWise and its individual components in isolation using in vitro and in vivo model systems. Results Foam cell formation was attenuated in human THP-1 macrophages treated with CardioWise. In addition, CardioWise reduced pro-inflammatory gene expression, monocyte recruitment and M1 macrophage phenotype polarisation. CardioWise was also found to increase HDL cholesterol levels and attenuate circulating levels of pro-inflammatory cytokines in wild type mice. Further investigation identified (+)-catechin within CardioWise as a key beneficial molecule to explore in greater detail. In vitro experiments demonstrated that catechin reduced monocyte migration and reactive oxygen species generation. Wild type mice treated with catechin were also found to receive anti-atherogenic benefits such as increased HDL cholesterol levels and reduced pro-inflammatory cytokine levels. Conclusion The findings of this study show that CardioWise and catechin are capable of exerting strong anti-inflammatory effects on several stages of atherosclerosis disease development in vitro. Furthermore initial in vivo studies using wild type mice revealed that both treatments are also capable of exerting several cardiovascular protective effects. Reasons for these beneficial effects have been proposed in this thesis and future studies outlined.

Subjects/Keywords: Q Science (General); RM Therapeutics. Pharmacology

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APA (6^th Edition):

Moss, J. (2018). Anti-inflammatory actions of nutraceuticals: Novel emerging therapies for atherosclerosis?. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/111849/

Chicago Manual of Style (16^th Edition):

Moss, Joe. “Anti-inflammatory actions of nutraceuticals: Novel emerging therapies for atherosclerosis?.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/111849/.

MLA Handbook (7^th Edition):

Moss, Joe. “Anti-inflammatory actions of nutraceuticals: Novel emerging therapies for atherosclerosis?.” 2018. Web. 10 Apr 2021.

Vancouver:

Moss J. Anti-inflammatory actions of nutraceuticals: Novel emerging therapies for atherosclerosis?. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/111849/.

Council of Science Editors:

Moss J. Anti-inflammatory actions of nutraceuticals: Novel emerging therapies for atherosclerosis?. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/111849/

Cardiff University

26. Padovan, Daniele. Continuous biomass valorisation with Sn-containing zeolite catalysts.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/113811/

► This work aims to provide a detailed study of the solid Lewis acid catalyst, Sn-Beta, and particularly focuses on its use as a catalyst for… (more)

▼ This work aims to provide a detailed study of the solid Lewis acid catalyst, Sn-Beta, and particularly focuses on its use as a catalyst for biomass valorisation. Particular emphasis is put on identifying several criteria that are necessary for evaluating the feasibility of the material for intensified operation during the continuous conversion of biomass, such as stability and productivity. The catalyst is tested in continuous flow apparatus for some relevant biomass reactions, such as the valorisation of furfural, and the isomerisation of glucose to fructose. Investigation of the deactivation mechanisms is done by combining kinetic data and characterisation of the material, both fresh and used, in order to relate spectroscopic evidence to catalytic performance. The understanding of deactivation is used to develop countermeasures in order to prevent or mitigate the undesired phenomenon. Important parts of the work are also focused on material synthesis and optimisation, and combinations of different catalysts are also explored, in order to improve the overall performance of the catalytic systems studied within the work. This thesis begins with a detailed study of the effect of metal loading on the intrinsic activity of Sn-Beta (Chapter 3), where a combination of kinetic experiments and characterisation techniques are presented. This permits identification of the most suitable catalyst for continuous flow catalysis. Continuous flow experiments are then carried out in order to probe the deactivation of the catalyst. A first study of the continuous performance of Sn- Beta focuses on the model reaction of the transfer hydrogenation of cyclohexanone to cyclohexanol (Chapter 4). Following this, the transfer hydrogenation of a more complex system is studied. Particularly, the cascade conversion of furfural to 2-(butoxymethyl) furan, through tandem transfer hydrogenation and etherification over bifunctional Sn-Beta catalysts, is studied (Chapter 5). Having identified the promising stability properties of Sn-Beta during organic phase reactions, the reported “water tolerance” of Sn-Beta is then probed during the continuous isomerisation of glucose to fructose (Chapter 6). Despite showing poor levels of activity and stability in bulk water solvent, excellent continuous performance is observed when solutions of methanol containing small amounts of water (1 – 10 wt. %) are employed. In closing (Chapter 7), the consequences of the findings of this research, in addition to the pertaining challenges these findings open, are also considered.

Subjects/Keywords: QD Chemistry

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APA (6^th Edition):

Padovan, D. (2018). Continuous biomass valorisation with Sn-containing zeolite catalysts. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/113811/

Chicago Manual of Style (16^th Edition):

Padovan, Daniele. “Continuous biomass valorisation with Sn-containing zeolite catalysts.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/113811/.

MLA Handbook (7^th Edition):

Padovan, Daniele. “Continuous biomass valorisation with Sn-containing zeolite catalysts.” 2018. Web. 10 Apr 2021.

Vancouver:

Padovan D. Continuous biomass valorisation with Sn-containing zeolite catalysts. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/113811/.

Council of Science Editors:

Padovan D. Continuous biomass valorisation with Sn-containing zeolite catalysts. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/113811/

Cardiff University

27. Bakx, Tom J.L.C. The Herschel bright sources sample.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/115889/

► Far-infrared observations have detected dusty star-forming galaxies, a subset of galaxies which is extremely dust-extincted from the ultraviolet down to near-infrared colours. Recent studies show… (more)

▼ Far-infrared observations have detected dusty star-forming galaxies, a subset of galaxies which is extremely dust-extincted from the ultraviolet down to near-infrared colours. Recent studies show that this population of sources contributes significantly to the history of star formation, especially out to very high redshift. Recent surveys with the Herschel Space Observatory have uncovered around half a million of these sources, with the largest of these surveys, the H-ATLAS, covering 616 square degrees. One of the most exciting discoveries is the lensing nature of the brightest of these sources, where the gravitational potential of a foreground galaxy lenses and amplifies the signal. The applications of gravitational lensing range from studying individual sources down to unprecidented resolution at high redshift in sub-mm wavelengths with ALMA, to cosmological studies by analysing the distribution of groups of lenses. In this thesis, I explore the effect of applying a more inclusive selection criterion for lensed sources, and study the properties of the sources that are selected. Whereas the first attempts at finding lensed sources use a strict S500μm > 100 mJy flux density cut, the sample I study is selected with a flux cut at 80 mJy: The Herschel Bright Sources (HerBS) sample. A photometric redshift cut of zphot > 2 is also taken, as most lensing takes place out at higher redshift. This redshift is calculated by fitting a spectral template to the 250, 350 and 500 μm observations from the Herschel SPIRE instrument. I push down the selection flux in order to select more lensed sources from the sub-mm surveys, whilst potentially including several unlensed sources. These unlensed sources could be among the most intrinsically luminous and star-forming objects in the Universe. Only less than five of such objects are known to exist, while our HerBS sample could contain up to 35 of these sources, which could teach us about the upper-limits of star-formation and their contribution to forming the most massive galaxies in the Universe. I use 850 μm SCUBA-2 observations on the James Clerk Maxwell Telescope (JCMT) to remove blazar interlopers, which results in 209 sources in the HerBS sample, after removing 14 blazar sources. At the time I wrote the paper upon which Chapter 2 is based, 24 sources had a spectroscopic redshift. I use this sub-sample to fit a two-temperature modified blackbody, and find a cold-body temperature of 21.3 K, a warm-body temperature of 45.8 K, a mass ratio of 26.7 and a dustemissivity index of 1.8. These values do not challenge the current knowledge of sub-mm galaxies, but the quality of the fit suggests a large diversity among the galaxies in the sub-sample, and that they are poorly fitted by a single template. This diversity is also found by the spectroscopic observations with the IRAM 30m-telescope observations on eight of the highest-redshift (zphot > 4) sources of the HerBS sample. We found five spectroscopic redshifts, with one of the sources at the highest known HerBS redshift at zspec =…

Subjects/Keywords: QB Astronomy; QC Physics

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APA (6^th Edition):

Bakx, T. J. L. C. (2018). The Herschel bright sources sample. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/115889/

Chicago Manual of Style (16^th Edition):

Bakx, Tom J L C. “The Herschel bright sources sample.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/115889/.

MLA Handbook (7^th Edition):

Bakx, Tom J L C. “The Herschel bright sources sample.” 2018. Web. 10 Apr 2021.

Vancouver:

Bakx TJLC. The Herschel bright sources sample. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/115889/.

Council of Science Editors:

Bakx TJLC. The Herschel bright sources sample. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/115889/

28. Amoako, Annika Nina. A systematic review of non-medical interventions in Rett Syndrome and a research study into attenuated behaviours in Rett Syndrome.

Degree: dclinpsy, 2018, Cardiff University

URL: http://orca.cf.ac.uk/115992/

► This thesis was submitted in May 2018 for the partial fulfilment of the award of Doctor in Clinical Psychology (DClinPsy) at Cardiff University. The thesis… (more)

▼ This thesis was submitted in May 2018 for the partial fulfilment of the award of Doctor in Clinical Psychology (DClinPsy) at Cardiff University. The thesis investigated a review of non-medical interventions in Rett Syndrome and the prevalence of attenuated behaviours in Rett Syndrome. Rett Syndrome is a rare neurodevelopmental genetic disorder which is characterised by period of outwardly typical development followed by a period of regression around 12-18 months. The regression is causes progressive disabilities in speech, motor and hand use. Physical comorbidities are often present including breathing difficulties, the requirement of feeding tubes, anxiety, gastrointestinal difficulties and orthopaedic issues. The condition is almost exclusive to females. Despite the inability to use their body to communicate, research has shown that individuals with Rett Syndrome are more intellectually capable than their body allows them to present. Paper 1 describes a systematic review of non-medical interventions researched into Rett Syndrome. The electronic databases were searched (Embase, PsychINFO and MEDLINE). Thirteen papers which met the quality rating threshold were reviewed and the methodology was assessed. Communication interventions were the most researched intervention. Alternative interventions included fitness and brainstem activation. Eleven of the studies described positive results. Recommendations for clinical practice and future research are made. Paper 2 describes an empirical study investigating the prevalence of attenuated behaviours [Autistic Catatonia] in Rett Syndrome and its presence during ‘Rett Episodes’. Parents of 28 individuals with Rett Syndrome completed questionnaires relating to attenuated behaviours and Rett Episodes. The findings revealed the presence of attenuated behaviour in individuals with Rett Episodes but this was not specific to Rett Episodes. The severity of attenuated behaviour was negatively correlated with age. Recommendations for clinical implications and further research are made. Paper 3 discusses an evaluation of the research process. The paper critically appraises the research across both papers including the strengths and limitations. The paper includes key reflections and process information that was not permitted within the constraints of the author guidelines for submission.

Subjects/Keywords: BF Psychology

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APA (6^th Edition):

Amoako, A. N. (2018). A systematic review of non-medical interventions in Rett Syndrome and a research study into attenuated behaviours in Rett Syndrome. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/115992/

Chicago Manual of Style (16^th Edition):

Amoako, Annika Nina. “A systematic review of non-medical interventions in Rett Syndrome and a research study into attenuated behaviours in Rett Syndrome.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/115992/.

MLA Handbook (7^th Edition):

Amoako, Annika Nina. “A systematic review of non-medical interventions in Rett Syndrome and a research study into attenuated behaviours in Rett Syndrome.” 2018. Web. 10 Apr 2021.

Vancouver:

Amoako AN. A systematic review of non-medical interventions in Rett Syndrome and a research study into attenuated behaviours in Rett Syndrome. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/115992/.

Council of Science Editors:

Amoako AN. A systematic review of non-medical interventions in Rett Syndrome and a research study into attenuated behaviours in Rett Syndrome. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/115992/

Cardiff University

29. Jaffa, Sarah. Statistical descriptors of clouds and clusters.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/116134/

► Star formation is a chaotic process, involving the evolution and interaction of a wide variety of structures. The interstellar medium exhibits substructure over a range… (more)

Subjects/Keywords: Q Science (General); QB Astronomy

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APA (6^th Edition):

Jaffa, S. (2018). Statistical descriptors of clouds and clusters. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/116134/

Chicago Manual of Style (16^th Edition):

Jaffa, Sarah. “Statistical descriptors of clouds and clusters.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/116134/.

MLA Handbook (7^th Edition):

Jaffa, Sarah. “Statistical descriptors of clouds and clusters.” 2018. Web. 10 Apr 2021.

Vancouver:

Jaffa S. Statistical descriptors of clouds and clusters. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/116134/.

Council of Science Editors:

Jaffa S. Statistical descriptors of clouds and clusters. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/116134/

Cardiff University

30. Dhiensawadkij, Duangkaew. Reproducing the politics of climate change: A study of Thai newspaper reporting.

Degree: PhD, 2018, Cardiff University

URL: http://orca.cf.ac.uk/116211/

► This thesis aims to investigate the news reporting of climate change issues in three Thai newspapers, examining in particular the part played by journalistic practices… (more)

▼ This thesis aims to investigate the news reporting of climate change issues in three Thai newspapers, examining in particular the part played by journalistic practices in their representation. Key concepts from theories of risk society and critical approaches to news production are employed to formulate the conceptual framework. In empirical terms, two methods are employed to gather and interpret evidence. Specifically, a textual analysis is employed to initially identify and assess how climate change issues were constructed in the three selected newspapers. It helps to document how journalistic values, newsworthiness and news narratives work to reproduce climate change as a global agenda. The findings interpret evidence that the officials and their claims dominate news related to climate change. These primary-definers exploit climate change issues to support the nationalist arguments related to national energy security, while environmentalists de-legitimize coal-fired power plant investment with climate change issues. The findings confirm economic and conflict framing in the news coverage. Next, semi-structured interviews with journalists and news sources produced insights into the newsgathering processes. Evidence confirms that removing environmental news beats from the structure of newsgathering, the so-called the news net, sustains the power of institutional sources over environmental news agendas. The scarcity of skilled environmental journalists who are keen on environmental politics in Thailand fundamentally intensifies environmental frame-blindness, usual source dependency, and polarisation in newsrooms. This results in dominating capital growth news frames and dominated environmental news frames. These circumstances strengthen the position of the officials and resourceful organisations as the primary-definers in news related to climate change. The thesis advances the central argument that journalistic practice sustains the definitional power of national officials regarding climate change politics in Thailand. Specifically, the selected newspapers report that reducing national emissions and solving climate change are priority issues, yet in actual fact the risks associated with climate change do not receive sufficient coverage. It is shown that by prioritising other types of environmental news, particularly around financial investment and legal issues, this news coverage fails to contribute to public understanding of sustainable development to an adequate extent

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APA (6^th Edition):

Dhiensawadkij, D. (2018). Reproducing the politics of climate change: A study of Thai newspaper reporting. (Doctoral Dissertation). Cardiff University. Retrieved from http://orca.cf.ac.uk/116211/

Chicago Manual of Style (16^th Edition):

Dhiensawadkij, Duangkaew. “Reproducing the politics of climate change: A study of Thai newspaper reporting.” 2018. Doctoral Dissertation, Cardiff University. Accessed April 10, 2021. http://orca.cf.ac.uk/116211/.

MLA Handbook (7^th Edition):

Dhiensawadkij, Duangkaew. “Reproducing the politics of climate change: A study of Thai newspaper reporting.” 2018. Web. 10 Apr 2021.

Vancouver:

Dhiensawadkij D. Reproducing the politics of climate change: A study of Thai newspaper reporting. [Internet] [Doctoral dissertation]. Cardiff University; 2018. [cited 2021 Apr 10]. Available from: http://orca.cf.ac.uk/116211/.

Council of Science Editors:

Dhiensawadkij D. Reproducing the politics of climate change: A study of Thai newspaper reporting. [Doctoral Dissertation]. Cardiff University; 2018. Available from: http://orca.cf.ac.uk/116211/

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Open Access Theses and Dissertations