You searched for publisher:"Queens University".
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Queens University
1.
Qasrawi, Yazan.
THE DYNAMIC RESPONSE OF CONCRETE FILLED FRP TUBES SUBJECTED TO BLAST AND IMPACT LOADING
.
Degree: Civil Engineering, 2014, Queens University
URL: http://hdl.handle.net/1974/8588 
► Blasts and impacts are two of the severest loads a structure can experience. Blast experimenters, however, have observed that the load imparted to a circular…
(more)
▼ Blasts and impacts are two of the severest loads a structure can experience. Blast experimenters, however, have observed that the load imparted to a circular member was lower than the predicted design load. Additionally, numerous investigations have established the superiority of concrete filled FRP tubes (CFFTs) over conventional reinforced concrete members. These observations indicated CFFTs’ potential to resist dynamic blast and impact loads. The experimental and numerical investigations presented in this thesis aimed to demonstrate the suitability of CFFTs to resist blast and impact loads, to determine the parameters that influence their behaviour under such loads, and to develop a design procedure for resisting these loads. The initial numerical investigation determined the reflected blast loading parameters experienced by a circular cross section. The experimental phase consisted of testing twelve full scale specimens, two monotonically, four under impact loading, and six under close-in blast loading. The monotonically tested specimens acted as controls for the entire program. The results of the impact testing investigation were used to develop and validate a non-linear single degree of freedom (SDOF) model. This impact phase also led to the development of relatively simple procedures for designing CFFTs under impact loading using either SDOF modeling or the conservation of energy. Analysis of the blast testing results led to the development of numerical procedures for obtaining an equivalent close-in blast loading for SDOF analysis of CFFTs and Pressure-Impulse diagrams. The use of SDOF modeling and conservation of energy in blast design were also discussed. Finally, a non-linear explicit dynamic model of CFFTs was developed using the commercial software ANSYS Autodyn. This model was verified using the experimental impact and blast test results and used to conduct a parametric study. The results of these investigations indicated that CFFTs were particularly suitable for blast and impact resistant applications, as their geometry diffracted blast waves and the addition of the tube increased their energy absorbing capacity significantly giving them additional strength and ductility. The tube also confined and protected the concrete core and simplified construction.
Subjects/Keywords: Concrete;
FRP;
Impact;
CFFT;
Blast
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APA (6th Edition):
Qasrawi, Y. (2014). THE DYNAMIC RESPONSE OF CONCRETE FILLED FRP TUBES SUBJECTED TO BLAST AND IMPACT LOADING
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8588
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Qasrawi, Yazan. “THE DYNAMIC RESPONSE OF CONCRETE FILLED FRP TUBES SUBJECTED TO BLAST AND IMPACT LOADING
.” 2014. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/8588.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Qasrawi, Yazan. “THE DYNAMIC RESPONSE OF CONCRETE FILLED FRP TUBES SUBJECTED TO BLAST AND IMPACT LOADING
.” 2014. Web. 19 Jan 2019.
Vancouver:
Qasrawi Y. THE DYNAMIC RESPONSE OF CONCRETE FILLED FRP TUBES SUBJECTED TO BLAST AND IMPACT LOADING
. [Internet] [Thesis]. Queens University; 2014. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/8588.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Qasrawi Y. THE DYNAMIC RESPONSE OF CONCRETE FILLED FRP TUBES SUBJECTED TO BLAST AND IMPACT LOADING
. [Thesis]. Queens University; 2014. Available from: http://hdl.handle.net/1974/8588
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
2.
Stermole, Krystina.
Venetian Art and the War of the League of Cambrai (1509-17)
.
Degree: Art History, 2009, Queens University
URL: http://hdl.handle.net/1974/5292
► This dissertation explores how Venetians used the figurative arts as a means of responding to and shaping their experience of the War of the League…
(more)
▼ This dissertation explores how Venetians used the figurative arts as a means of responding to and shaping their experience of the War of the League of Cambrai (1509–17). The war was the most politically and spiritually tumultuous conflict in Venice’s history and almost resulted in the loss of its mainland empire. To provide a sense of the complexity of the relationship between art and contemporary military events, the study gathers and analyses a wide range of works, from painting and sculpture to woodcuts for books and prints. Chapters two, three, and four investigate how Venetians used visual art to represent and interpret their struggle to reclaim the former terraferma empire. Chapter two begins the discussion by examining the modest woodcuts accompanying printed propagandistic texts that were inspired by the battle for the mainland and that constitute the first visual response to the war. Chapter three explores the interpretation afforded military events by subsequent and more enduring works of art, particularly sculpted altarpieces and tombs for mercenaries. Chapter four discusses the assertive revival of more traditional visual themes, particularly the lion of St. Mark. Chapters five, six, and seven, in contrast, address how Venetian art reflects the atmosphere of spiritual crisis generated by the popular interpretation of the war as a form of divine punishment. The first of these demonstrates how devotional books responded to the unsettled mood through text and image. Chapter six proposes that the wartime popularity of multi-block woodcuts, particularly of religious subjects, similarly reflects a market for certain kinds of devotional imagery. To conclude, chapter seven argues that the same atmosphere sparked a sudden interest during the war and shortly thereafter in paintings of Christ and the adulteress. Considered as a group, the studies presented by the various chapters demonstrate that Venetians produced a wide variety of art during the Cambrai War as a means of interpreting the conflict’s significance and influencing its course.
Subjects/Keywords: Venice;
Art;
Cambrai War
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APA (6th Edition):
Stermole, K. (2009). Venetian Art and the War of the League of Cambrai (1509-17)
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5292
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stermole, Krystina. “Venetian Art and the War of the League of Cambrai (1509-17)
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5292.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stermole, Krystina. “Venetian Art and the War of the League of Cambrai (1509-17)
.” 2009. Web. 19 Jan 2019.
Vancouver:
Stermole K. Venetian Art and the War of the League of Cambrai (1509-17)
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5292.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stermole K. Venetian Art and the War of the League of Cambrai (1509-17)
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/5292
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
3.
Beaulieu, Michel S.
A Proletarian Prometheus: Socialism, Ethnicity, and Revolution at the Lakehead, 1900-1935
.
Degree: History, 2009, Queens University
URL: http://hdl.handle.net/1974/1715
► “The Proletarian Prometheus: Socialism, Ethnicity, and Revolution at the Lakehead, 1900-1935” is an analysis of the various socialist organizations operating at the Canadian Lakehead (comprised…
(more)
▼ “The Proletarian Prometheus: Socialism, Ethnicity, and Revolution at the Lakehead, 1900-1935” is an analysis of the various socialist organizations operating at the Canadian Lakehead (comprised of the twin cities of Port Arthur and Fort William, Ontario, now the present-day City of Thunder Bay, and their vicinity) during the first 35 years of the twentieth century. It contends that the circumstances and actions of Lakehead labour, especially those related to ideology, ethnicity, and personality, worked simultaneously to empower and to fetter workers in their struggles against the shackles of capitalism. The twentieth-century Lakehead never lacked for a population of enthusiastic, energetic and talented left-wingers. Yet, throughout this period the movement never truly solidified and took hold. Socialist organizations, organizers and organs came and went, leaving behind them an enduring legacy, yet paradoxically the sum of their efforts was cumulatively less than the immense sacrifices and energies they had poured into them. Between 1900 and 1935, the region's working-class politics was shaped by the interaction of ideas drawn from the much larger North Atlantic socialist world with the particularities of Lakehead society and culture. International frameworks of analysis and activism were of necessity reshaped and revised in a local context in which ethnic divisions complicated and even undermined the class identities upon which so many radical dreams and ambitions rested.
Subjects/Keywords: Canada;
Socialism;
Labour History;
Communist Party of Canada;
Industrial Workers of the World;
Northwestern Ontario;
Lakehead;
Social Democratic Party of Canada;
Socialist Party of Canada;
One Big Union;
Winnipeg General Strike;
Finns in Canada;
Port Arthur, Ontario;
Fort William, Ontario;
1900-1935;
Ethnicity;
Revolution;
Radicalism
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APA ·
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Export
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Manager
APA (6th Edition):
Beaulieu, M. S. (2009). A Proletarian Prometheus: Socialism, Ethnicity, and Revolution at the Lakehead, 1900-1935
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1715
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Beaulieu, Michel S. “A Proletarian Prometheus: Socialism, Ethnicity, and Revolution at the Lakehead, 1900-1935
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1715.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Beaulieu, Michel S. “A Proletarian Prometheus: Socialism, Ethnicity, and Revolution at the Lakehead, 1900-1935
.” 2009. Web. 19 Jan 2019.
Vancouver:
Beaulieu MS. A Proletarian Prometheus: Socialism, Ethnicity, and Revolution at the Lakehead, 1900-1935
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1715.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Beaulieu MS. A Proletarian Prometheus: Socialism, Ethnicity, and Revolution at the Lakehead, 1900-1935
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1715
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
4.
Michel, Claire S.
The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
.
Degree: Pathology & Molecular Medicine, 2009, Queens University
URL: http://hdl.handle.net/1974/1741
► An estimated 5-10% of breast cancers are hereditary in nature and are due to the presence of a mutation in a breast cancer predisposition gene;…
(more)
▼ An estimated 5-10% of breast cancers are hereditary in nature and are due to the presence of a mutation in a breast cancer predisposition gene; approximately half of these cases possess a mutation in BRCA1 or BRCA2. Many BRCA1/BRCA2 mutations result in a truncated protein and hence are unequivocally disease-causing. However another class of mutations, the Variants of Unknown Significance (VUS), are more problematic as the effect of these mutations on protein function is unclear. The inability to classify these mutations as disease causing generates significant problems in risk evaluation, counseling and preventive care. Accordingly we sought to determine whether carriers of either a BRCA1 or BRCA2 mutation could be identified from non-carriers based on the gene expression patterns of non-cancerous cells.
EBV-transformed lymphoblastoid cell lines established from BRCA1/BRCA2 mutation carriers and normal individuals were obtained through the NIH Breast Cancer Family Registries. Cell lines were mock-irradiated or treated with ionizing radiation (2 Gy). Following a recovery period of 6 hours total RNA was extracted and whole genome gene expression profiling was carried out. Molecular classifiers comparing the baseline expression profiles and the radiation-dependent expression profiles of BRCA1/BRCA2 mutation carriers to control individuals were created using a Support Vector Machine (SVM) coupled with a recursive feature removal (RFR) algorithm.
Our results suggest that cell populations derived from BRCA1/BRCA2 mutation carriers display unique expression phenotypes from those of control individuals in both the basal and radiation-induced cases. In the task of classification using baseline expression, the BRCA1-classifier correctly classified 15/18 test samples using feature selection based on the training set only, while feature selection using the entire dataset (AD) improved classification to 16/18 samples. The BRCA2-baseline classifier correctly classified 13/17 and 14/17 (AD) samples, respectively. In the task of radiation-dependent classification, the BRCA1-IR classifier correctly classified 12/18 and 16/18 (AD) test samples respectively while the BRCA2-IR classifier correctly classified 13/17 and 16/17 (AD) test samples respectively. These results suggest the possibility of development of this assay into a novel hereditary breast cancer screening diagnostic able to accurately identify the presence of BRCA1 or BRCA2 mutations via a functional assay thereby improving patient outcomes.
Subjects/Keywords: BRCA1;
BRCA2;
Hereditary Breast Cancer;
Microarrays;
Cancer Screening;
Mutation Carriers
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APA ·
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CSE |
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Michel, C. S. (2009). The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1741
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Michel, Claire S. “The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1741.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Michel, Claire S. “The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
.” 2009. Web. 19 Jan 2019.
Vancouver:
Michel CS. The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1741.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Michel CS. The Identification of BRCA1 and BRCA2 Mutation Carriers Using Functional Genomic Assays
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1741
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
5.
Fobih, Nick.
Political Parties and Democratic Development in Ghana: From Transition to Consolidation and Beyond
.
Degree: Political Studies, 2016, Queens University
URL: http://hdl.handle.net/1974/13944
► At the time of the Ghana’s independence in March 1957, a democratic system of government was instituted, but the process of political development was derailed…
(more)
▼ At the time of the Ghana’s independence in March 1957, a democratic system of government was instituted, but the process of political development was derailed and often interrupted by frequent coups. This is evident in the interchange of military and civilian regimes in the last fifty-one years. While in the post-independence era, the development of democracy, the party system and democratic institutions in Ghana has taken many twists and turns due to the persistent military interventions in politics, as part of the third-wave of democratization, in 1992, under Ghana’s Fourth Republic, a new democratic system was re-introduced in the country under the National Democratic Congress (NDC) government. The opening of political spaces for the political parties and civil society organizations in the last two decades has witnessed the resurgence of political parties of different sizes and ideological orientation under various political traditions, which has led to the strengthening of Ghana’s party system.
This, in turn, has immensely facilitated the country’s democratic development, which was evidenced in the 2000 power alternation that led to the election of the New Patriotic Party (NPP) to power. Since the emergence of the third-wave of democratization, there have been numerous theoretical approaches by democratic transition and consolidation theorists on the role of political parties in the nurturing and consolidation of democracy in the third-wave countries. This study examines the internal organization of parties and their role in Ghana’s democratic transition and consolidation. On the basis of the evidence presented in this study, it can be concluded that while the political parties have been the bedrock for Ghana’s democratic transition and consolidation processes, there are a number of key issues such as internal party democracy and candidate selection processes that needed to be resolved by the political parties in order to strengthen Ghana’s democratic consolidation process.
Subjects/Keywords: Ghana, Political Parties;
Democracy, Transition, Consolidation
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APA (6th Edition):
Fobih, N. (2016). Political Parties and Democratic Development in Ghana: From Transition to Consolidation and Beyond
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/13944
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fobih, Nick. “Political Parties and Democratic Development in Ghana: From Transition to Consolidation and Beyond
.” 2016. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/13944.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fobih, Nick. “Political Parties and Democratic Development in Ghana: From Transition to Consolidation and Beyond
.” 2016. Web. 19 Jan 2019.
Vancouver:
Fobih N. Political Parties and Democratic Development in Ghana: From Transition to Consolidation and Beyond
. [Internet] [Thesis]. Queens University; 2016. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/13944.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fobih N. Political Parties and Democratic Development in Ghana: From Transition to Consolidation and Beyond
. [Thesis]. Queens University; 2016. Available from: http://hdl.handle.net/1974/13944
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
6.
Mayne, Richard Oliver.
The Annapolis Riddle: Advocacy, Ship Design and the Canadian Navy's Force Structure Crisis, 1957-1965.
Degree: History, 2013, Queens University
URL: http://hdl.handle.net/1974/8298
► The General Purpose Frigate was the centrepiece of the Royal Canadian Navy’s fleet planning for over three years, and its cancellation by the newly elected…
(more)
▼ The General Purpose Frigate was the centrepiece of the Royal Canadian Navy’s fleet planning for over three years, and its cancellation by the newly elected Liberal government in October 1963 set off a divisive and chaotic yearlong debate over what should be built in its place. After exploring numerous options, such as aircraft carriers and nuclear submarines, the navy came to the conclusion that its best option was to pursue a guided missile destroyer program that was similar to the General Purpose Frigate. What happened next has confounded a number of modern naval historians. Just as the navy was about to acquire its long sought after guided missile destroyers, a decision was made to build four smaller specialized anti-submarine vessels that would repeat the less sophisticated Annapolis class instead.
Although a number of theories have been put forward to explain this decision, the one common factor among these hypotheses is the notion that an egocentric and dominant defence minister named Paul Hellyer forced the Repeat Annapolis upon a reluctant navy that unanimously despised the concept. According to these interpretations, both the Repeat Annapolis and General Purpose Frigate were reflective of a larger debate over whether the navy should have the capability to participate in more versatile operations, such as containing limited wars in the Third World, or maintaining a specialised antisubmarine fleet. Conventional wisdom, therefore, suggest that Hellyer’s selection of the repeat Annapolis was indicative of a minister who gave the navy little choice but to specialize in anti-submarine warfare. This dissertation, however, challenges this premise by arguing that the navy was far from united over its force structure - a term used to describe the process through which the navy selects the types of ships it requires to fulfil its current and future roles. Instead, it will show how the birth of the Repeat Annapolis was actually the product of conflicting opinions and struggles from within the navy itself. Understanding the self-inflicted damage resulting from these conflicts is crucial, particularly since the force structure that emerged from this chaotic period (1957 - 1965) would influence the composition of the Canadian navy for the next forty years.
Subjects/Keywords: Military History;
Naval Leadership
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APA ·
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Manager
APA (6th Edition):
Mayne, R. O. (2013). The Annapolis Riddle: Advocacy, Ship Design and the Canadian Navy's Force Structure Crisis, 1957-1965.
(Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8298
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mayne, Richard Oliver. “The Annapolis Riddle: Advocacy, Ship Design and the Canadian Navy's Force Structure Crisis, 1957-1965.
” 2013. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/8298.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mayne, Richard Oliver. “The Annapolis Riddle: Advocacy, Ship Design and the Canadian Navy's Force Structure Crisis, 1957-1965.
” 2013. Web. 19 Jan 2019.
Vancouver:
Mayne RO. The Annapolis Riddle: Advocacy, Ship Design and the Canadian Navy's Force Structure Crisis, 1957-1965.
[Internet] [Thesis]. Queens University; 2013. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/8298.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mayne RO. The Annapolis Riddle: Advocacy, Ship Design and the Canadian Navy's Force Structure Crisis, 1957-1965.
[Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/8298
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
7.
Gee, Marianne.
Blood pressure control among Canadians with hypertension, with and without diabetes
.
Degree: Community Health and Epidemiology, 2013, Queens University
URL: http://hdl.handle.net/1974/8462
► The thesis offers the following contributions to the epidemiology of hypertension in Canada: 1.The first manuscript uses cross-sectional data from the 2007-2009 Canadian Health Measures…
(more)
▼ The thesis offers the following contributions to the epidemiology of hypertension in Canada:
1.The first manuscript uses cross-sectional data from the 2007-2009 Canadian Health Measures Survey (CHMS) to compare the prevalence of controlled hypertension between people with and without diabetes. Of the 74% of Canadians with diabetes who had hypertension, 56% (95% CI: 45%-66%) had controlled blood pressure compared to 64% (95% CI: 58%-69%) of Canadians without diabetes. Among people taking medication, individuals with diabetes were less likely to have controlled hypertension (ORadjusted: 0.3; 95% CI: 0.2-0.6).
2.The objective of the second manuscript was to determine, among Canadians with hypertension, whether individuals with diabetes were less likely than those without to recall health professional advice for healthy behaviours and whether receipt of such advice influences behaviour, using cross-sectional data from the 2009 Survey on Living with Chronic Diseases in Canada (SLCDC). Canadians with diabetes were more likely than those without to recall advice to control/lose weight (81% vs. 66%), exercise (79% vs. 68%), limit alcohol (78% vs. 55%) and modify diet (70% vs. 61%) but not limit salt (65% vs. 64%). Both groups were equally likely to report following advice, with receipt of advice positively associated with engagement in healthy behaviours.
3. The third manuscript describes knowledge of blood pressure targets in Canadians with hypertension using cross-sectional data from the 2009 SLCDC. Knowledge of blood pressure targets was low, with 28% and 32% of Canadians with and without diabetes reporting having discussed a blood pressure target and reporting a target in line with clinical practice guidelines.
4.The fourth manuscript validates an existing self-reported blood pressure control question in a sample of 161 patients with hypertension in Kingston. In people with and without diabetes, the question had sensitivities of 83% ± 11% and 78% ± 10% and specificities of 30% ±19% and 58% ± 21%, respectively.
5.The final manuscript tests a method designed to account for misclassification in epidemiologic studies, using data from the CHMS. The method was found to perform inconsistently in multivariate contexts and introduced bias when minor differential misclassification was ignored.
Subjects/Keywords: Blood pressure control;
Diabetes;
Hypertension;
Epidemiology
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gee, M. (2013). Blood pressure control among Canadians with hypertension, with and without diabetes
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8462
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gee, Marianne. “Blood pressure control among Canadians with hypertension, with and without diabetes
.” 2013. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/8462.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gee, Marianne. “Blood pressure control among Canadians with hypertension, with and without diabetes
.” 2013. Web. 19 Jan 2019.
Vancouver:
Gee M. Blood pressure control among Canadians with hypertension, with and without diabetes
. [Internet] [Thesis]. Queens University; 2013. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/8462.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gee M. Blood pressure control among Canadians with hypertension, with and without diabetes
. [Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/8462
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
8.
Huva, Emily.
Tetrahydrofuran Hydrate Inhibitors: Ice-Associating Bacteria and Proteins
.
Degree: Biology, 2009, Queens University
URL: http://hdl.handle.net/1974/1728
► Ice-associating proteins (IAPs) are proteins that interact directly with ice crystals, either by offering a site for nucleation, i.e. ice nucleating proteins (INPs), or by…
(more)
▼ Ice-associating proteins (IAPs) are proteins that interact directly with ice crystals, either by offering a site for nucleation, i.e. ice nucleating proteins (INPs), or by binding to nascent crystals to prevent addition of more water molecules, i.e. antifreeze proteins (AFPs). AFPs have been found to inhibit the formation of clathrate-hydrates, ice-like crystalline solids composed of water-encaged guest molecules. Study of AFP-hydrate interaction is leading to a greater understanding of AFP adsorption and of the mechanism behind the “memory effect” in hydrates, wherein previously frozen crystals reform more quickly after a brief melt. AFP is currently the only known memory inhibitor. Such a low-dosage hydrate inhibitor (LDHI) is of great interest to the oil and gas industry, as hydrate formation and reformation in the field is a huge problem. Bacterial AFPs, though largely uncharacterized, may be the best candidates for large-scale production of hydrate inhibitors, given the difficulties in obtaining AFP from other sources.
The popular kinetic inhibitors (KIs) polyvinylpyrrolidone (PVP) and polyvinylcaprolactam (PVCap) were used for points of comparison in experiments exploring the hydrate-inhibition activity of several ice-associating bacteria and proteins. The addition of the soil microbe, Chryseobacterium, increased the average lag-time to tetrahydrofuran (THF) hydrate formation by 14-fold, comparable to PVP or PVCap. Samples containing Pseudomonas putida, a bacterium having both ice-nucleation protein (INP) and AFP activity, had lag-times double that of the control. Solutions with P. putida and Chryseobacterium sometimes formed hydrate slurries of stunted crystal nuclei instead of solid crystals. No inhibition of memory or nucleation was noted in bacterial assays, however bacteria with INP activity was linked to unusually rapid memory reformation. Quartz crystal microbalance experiments with dissipation (QCM-D) showed that a tight adsorption to SiO2 and resistance to rinsing are correlated with a molecule’s inhibition of hydrate formation and reformation. These results support a heterogeneous nucleation model of the memory effect, and point to the affinity of AFP for heterogeneous nucleating particles as an important component of memory inhibition.
Subjects/Keywords: antifreeze protein;
ice nucleating protein;
tetrahydrofuran;
gas hydrate;
memory effect;
kinetic inhibitors;
adsorption;
quartz crystal microbalance
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APA (6th Edition):
Huva, E. (2009). Tetrahydrofuran Hydrate Inhibitors: Ice-Associating Bacteria and Proteins
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1728
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Huva, Emily. “Tetrahydrofuran Hydrate Inhibitors: Ice-Associating Bacteria and Proteins
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1728.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Huva, Emily. “Tetrahydrofuran Hydrate Inhibitors: Ice-Associating Bacteria and Proteins
.” 2009. Web. 19 Jan 2019.
Vancouver:
Huva E. Tetrahydrofuran Hydrate Inhibitors: Ice-Associating Bacteria and Proteins
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1728.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Huva E. Tetrahydrofuran Hydrate Inhibitors: Ice-Associating Bacteria and Proteins
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1728
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
9.
Bamforth, Emily.
Multibranched rangeomorphs from the Ediacaran Mistaken Point assemblage, Newfoundland, Canada
.
Degree: Geological Sciences and Geological Engineering, 2010, Queens University
URL: http://hdl.handle.net/1974/5433
► Rangeomorphs are a distinct group of millimeter- to meter-scale soft-bodied macrofossils that are restricted to the latter half of the late Neoproterozoic Ediacaran Period (635Ma-…
(more)
▼ Rangeomorphs are a distinct group of millimeter- to meter-scale soft-bodied macrofossils that are restricted to the latter half of the late Neoproterozoic Ediacaran Period (635Ma- 542Ma). These fossils represent an extinct higher level taxon characterized by a modular construction based on a single architectural unit: the centimeter-scale, chevron-shaped rangeomorph element which displays several orders of self-similar branching. These elements could be arranged in a variety of different ways, constituting the wide array of gross morphologies found within the Group Rangeomorpha. The largest and most diverse assemblage of rangeomorph fossils in the world is found at Mistaken Point, on the Avalon Peninsula of Newfoundland, Canada, where these organisms are preserved within their original, in situ paleocommunities. Multibranched rangeomorphs are typified by bush-, comb- and network-shaped fossils which display multiple rangeomorph-bearing structures attached to an untethered basal stolon or central attachment point.
Multibranched, comb-shaped rangeomorphs are endemic to Mistaken Point, and are represented by fossils displaying multiple parallel struts emerging along one side of an elongate, curved pedicle rod. Morphological and taphonomic evidence suggests that, in life, this organism had two rows of struts, each bearing a rangeomorph frondlet, arranged in an alternating pattern along the curved, tubular pedicle rod. Biometric analyses imply that the struts were added to both ends of the pedicle rod throughout the organism’s lifetime, with later inflation of the rangeomorph frondlets. Each comb-shaped rangeomorph locality likely represents a different age cohort within the organism’s lifecycle, providing rare evidence for spatfall reproduction in Ediacarans, which is similar to that found in modern macrobenthic organisms with pelagic larvae.
Network-shaped multibranched rangeomorphs, represented by symmetrical to asymmetrical net-like fossils, are also endemic to Mistaken Point. This genus is reconstructed as having a symmetrical arrangement of flexible, rangeomorph-bearing leaflets that were, in part, neutrally buoyant with respect to the seawater. This flexible leaflet structure is unique, and shared only with a rare, previously undescribed, Ediacaran frond-like organism. It is suggested that the enigmatic leaflet structures shared by these two morphologically distinct taxa represent a new type of rangeomorph branching architecture, and therefore constitute a new type of rangeomorph.
Subjects/Keywords: Ediacaran;
Paleontology;
Mistaken Point;
Rangeomorphs;
Neoproterozoic;
Paleoecology
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bamforth, E. (2010). Multibranched rangeomorphs from the Ediacaran Mistaken Point assemblage, Newfoundland, Canada
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5433
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bamforth, Emily. “Multibranched rangeomorphs from the Ediacaran Mistaken Point assemblage, Newfoundland, Canada
.” 2010. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5433.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bamforth, Emily. “Multibranched rangeomorphs from the Ediacaran Mistaken Point assemblage, Newfoundland, Canada
.” 2010. Web. 19 Jan 2019.
Vancouver:
Bamforth E. Multibranched rangeomorphs from the Ediacaran Mistaken Point assemblage, Newfoundland, Canada
. [Internet] [Thesis]. Queens University; 2010. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5433.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bamforth E. Multibranched rangeomorphs from the Ediacaran Mistaken Point assemblage, Newfoundland, Canada
. [Thesis]. Queens University; 2010. Available from: http://hdl.handle.net/1974/5433
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
10.
Kapuscinski, Kiley.
Dames of Distress: Female Violence and Revised Socio-Cultural Discourses in the Fiction of Margaret Atwood
.
Degree: English, 2009, Queens University
URL: http://hdl.handle.net/1974/5319
► This study examines the figure of the violent woman in Atwood’s fiction as a productive starting point for the re-evaluation of various socio-cultural debates. Emerging…
(more)
▼ This study examines the figure of the violent woman in Atwood’s fiction as a productive starting point for the re-evaluation of various socio-cultural debates. Emerging from Atwood’s conviction that art, in its various forms, is often involved in the re-writing of convention, I begin by re-defining traditional constructions of womanhood and violence in order to evince the reformative work and often unconventional forms of brutality employed by women in Atwood’s novels, including Surfacing, The Blind Assassin, Lady Oracle, and Cat’s Eye, and in her collections of short fiction, such as Dancing Girls, Bluebeard’s Egg, The Penelopiad, and The Tent. Throughout, I demonstrate the ambivalence of violence as both destructive and generative, Canadian and un-Canadian, and Atwood’s drawing on this destabilizing ambivalence in order to propose change within her broader social milieu. More precisely, the introductory chapter offers an overview of representations of female violence in Canadian fiction, and of the various responses to this figure as she appears in Atwood’s fiction, that point to the need for a critical vocabulary that addresses women’s capacity to enact harm. The second chapter examines the various mythologies that define Canada and its people, and how the violent woman troubles these mythologies by inciting recognition of national identity as a narrative process open to re-evaluation. The third chapter moves away from this focus on national narratives to highlight the discourses that similarly shape our understanding of art, and those who participate in it. Here, the violent woman can be seen to engage in revisionary work by exposing the limits of the Red Shoes Syndrome that has in many ways come to define the fraught relationship between the female artist and her art. The final chapter examines Atwood’s on-going fascination with various kinds of mythologies and her revisions of Classical and Biblical myths in order to highlight the veritable range of female violence and the possibility, and at times necessity, of responding to these behaviors in ways that circumnavigate traditionally masculine forms of justice ethics. In focusing on how Atwood’s violent women engage these various socio-cultural discourses, this study concludes that traditionally marginal and nonliterary figures can perform central and necessary roles and that Atwood’s fiction responds to, and in turn (re)creates, the social environment from which it emerges.
Subjects/Keywords: Margaret Atwood;
violence
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APA ·
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MLA ·
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Export
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Manager
APA (6th Edition):
Kapuscinski, K. (2009). Dames of Distress: Female Violence and Revised Socio-Cultural Discourses in the Fiction of Margaret Atwood
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5319
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kapuscinski, Kiley. “Dames of Distress: Female Violence and Revised Socio-Cultural Discourses in the Fiction of Margaret Atwood
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5319.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kapuscinski, Kiley. “Dames of Distress: Female Violence and Revised Socio-Cultural Discourses in the Fiction of Margaret Atwood
.” 2009. Web. 19 Jan 2019.
Vancouver:
Kapuscinski K. Dames of Distress: Female Violence and Revised Socio-Cultural Discourses in the Fiction of Margaret Atwood
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5319.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kapuscinski K. Dames of Distress: Female Violence and Revised Socio-Cultural Discourses in the Fiction of Margaret Atwood
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/5319
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
11.
Mcpherson, Victor.
DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE PHOSPHATASE IN FcepsilonRI SIGNALING IN MAST CELLS
.
Degree: Biochemistry, 2009, Queens University
URL: http://hdl.handle.net/1974/5274
► Mast cells are granulocytes that are a key component of the innate and adaptive immune system, and contribute to allergic disorders. Mast cell activation following…
(more)
▼ Mast cells are granulocytes that are a key component of the innate and adaptive immune system, and contribute to allergic disorders. Mast cell activation following clustering of the high affinity IgE receptor (FcepsilonRI) by multivalent antigens requires reversible tyrosine phosphorylation of myriad signaling proteins. Activated mast cells rapidly release granule contents (eg. histamine and serine proteases) that cause vascular permeability, and in a more delayed manner they also synthesize and secrete eicosanoids and numerous cytokines (eg. IL-6 and TNFalpha) that recruit activated leukocytes. FcepsilonRI signaling is initiated by Lyn, a Src Family Kinase (SFK), that phosphorylates immunoreceptor tyrosine-based activation motifs (ITAMs) found on the FcepsilonRI beta and gamma chains. This allows recruitment of Fyn SFK and Syk kinase that bind ITAMs and phosphorylate numerous downstream targets. Src Homology 2 domain-containing Phosphatase 2 (SHP2, encoded by ptpn11/shp2) is known to be recruited to several phosphorylated proteins following FcepsilonRI aggregation in mast cells, however attempts to define the role of SHP2 have been hampered by its essential role during embryonic development and hematopoiesis in mice. Recently, conditional SHP2 knock-out mice (shp2fl/fl) have been created allowing for shp2 inactivation in a tissue-specific manner by Cre recombinase. Here we describe the use of transgenic mice expressing a modified estrogen receptor-Cre Recombinase (TgCreER*) on a shp2fl/fl genetic background, that allows for maturation of bone marrow-derived mast cells (BMMCs) prior to shp2-inactivation using 4-hydroxytamoxifen (4OH-TM). SHP2-depleted BMMCs display reduced phosphorylation of the FcepsilonRI beta chain, but exhibit extended phosphorylation of Syk kinase. Additionally, SHP2-deficient cells display a defect in the activation of both Erk mitogen-activated protein kinase and Akt, which correlates with an observed defect in the production of TNFalpha and Leukotriene C4. Finally, we show that SHP2-deficient BMMCs display elevated FcepsilonRI-evoked phosphorylation of Csk-Binding Protein (Cbp or PAG) on residue Y317, which recruits C-terminal Src kinase (Csk) that phosphorylates SFKs on an inhibitory tyrosine. This hyperphosphorylation of Cbp correlates with elevated phosphorylation of the C-terminal inhibitory tyrosine on Fyn kinase. This study provides new insights into the role of SHP2 as a positive effector of FcepsilonRI signaling and cytokine production in mast cells.
Subjects/Keywords: Mast Cells;
SHP2;
FcepsilonRI;
Cytokine Production
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APA ·
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Export
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APA (6th Edition):
Mcpherson, V. (2009). DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE PHOSPHATASE IN FcepsilonRI SIGNALING IN MAST CELLS
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5274
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mcpherson, Victor. “DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE PHOSPHATASE IN FcepsilonRI SIGNALING IN MAST CELLS
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5274.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mcpherson, Victor. “DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE PHOSPHATASE IN FcepsilonRI SIGNALING IN MAST CELLS
.” 2009. Web. 19 Jan 2019.
Vancouver:
Mcpherson V. DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE PHOSPHATASE IN FcepsilonRI SIGNALING IN MAST CELLS
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5274.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mcpherson V. DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE PHOSPHATASE IN FcepsilonRI SIGNALING IN MAST CELLS
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/5274
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
12.
Calder, Kristina.
An Investigation into the Pathophysiology of Non-Specific Arm Pain: an Examination of the Utility and Reliability of Quantitative Electomyography
.
Degree: Rehabilitation Science, 2009, Queens University
URL: http://hdl.handle.net/1974/5322
► The wrist extensor muscles have been implicated in a work-related upper limb disorder referred to as non-specific arm pain (NSAP), which has an unknown pathophysiology.…
(more)
▼ The wrist extensor muscles have been implicated in a work-related upper limb disorder referred to as non-specific arm pain (NSAP), which has an unknown pathophysiology. The primary objective of this thesis was to perform an electrophysiological evaluation of NSAP to gain a better understanding of the underlying pathophysiology. Secondary objectives were to determine the utility and reliability of the decomposition-based quantitative electromyography (DQEMG) system used to examine NSAP.
The utility of the DQEMG system was first tested to determine whether physiological changes in muscles of healthy individuals performing low-level fatiguing contractions could be detected using this approach. Next, the reliability of the outcome variables produced through this system was tested on healthy individuals performing low-level non-fatiguing contractions. A case-control study was then performed using DQEMG to determine whether there were measurable changes in electrophysiological variables that suggest whether NSAP is myopathic or neuropathic in nature. Finally, the case control study was repeated using a less invasive approach of electrophysiological evaluation to determine if this method might be equally useful in determining the pathophysiology of NSAP.
Results revealed DQEMG can be effectively and reliably used to detect changes in the physiological characteristics of motor units that accompany fatigue. Specifically, decreases in mean motor unit firing rates along with increases in amplitude, duration, and area parameters of needle- and surface-detected motor unit potentials (MUPs) suggest that recruitment is a main cause of increased electromyographic amplitude parameters with fatigue. Results of the reliability study suggested that DQEMG provides sufficiently consistent results to allow it to be effectively used for quantitative electromyographic (QEMG) analysis. In the first case control study, the QEMG parameters suggested that the underlying pathophysiology in NSAP may be myopathic in nature; specifically, QEMG findings for the NSAP group revealed smaller MUPs compared to the other groups. Lastly, the case control study using spike shape analysis across different levels of isometric wrist extension contractions was deemed to be useful in determining differences among the groups. This research suggests that NSAP may be myopathic in nature, since the NSAP group showed significantly lower mean spike amplitude and mean spike slope values compared to healthy subjects.
Subjects/Keywords: decomposition-based quantitative electromyography;
non-specific arm pain
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Calder, K. (2009). An Investigation into the Pathophysiology of Non-Specific Arm Pain: an Examination of the Utility and Reliability of Quantitative Electomyography
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5322
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Calder, Kristina. “An Investigation into the Pathophysiology of Non-Specific Arm Pain: an Examination of the Utility and Reliability of Quantitative Electomyography
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5322.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Calder, Kristina. “An Investigation into the Pathophysiology of Non-Specific Arm Pain: an Examination of the Utility and Reliability of Quantitative Electomyography
.” 2009. Web. 19 Jan 2019.
Vancouver:
Calder K. An Investigation into the Pathophysiology of Non-Specific Arm Pain: an Examination of the Utility and Reliability of Quantitative Electomyography
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5322.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Calder K. An Investigation into the Pathophysiology of Non-Specific Arm Pain: an Examination of the Utility and Reliability of Quantitative Electomyography
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/5322
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
13.
Clark, Kenneth.
A New and Improved Spin-Dependent Dark Matter Exclusion Limit Using the PICASSO Experiment
.
Degree: Physics, Engineering Physics and Astronomy, 2009, Queens University
URL: http://hdl.handle.net/1974/5323
► The PICASSO project is a direct dark matter search experiment located 2070 metres underground in SNOLAB. Superheated droplets of Freon (C4F10) are used as the…
(more)
▼ The PICASSO project is a direct dark matter search experiment located 2070 metres underground in SNOLAB. Superheated droplets of Freon (C4F10) are used as the active mass, providing a target for the incoming neutralinos. Recoiling nuclei deposit energy in the superheated Freon droplets, triggering a phase transition, the pressure waves of which can be detected using piezo-electric sensors.
Previously published limits using an exposure of 1.98 +/- 0.19 kg day obtained a peak spin-dependent cross section exclusion limit for neutralino-proton interactions of 1.31 pb at a neutralino mass of 29 GeV/c2 at a 90% confidence level. Improvements in the detectors installed in the underground experiment have provided 20.99 +/- 0.25 kg day for analysis and improvements in the analysis method have produced an exclusion limit of 2.9 X 10^(-2) pb at a neutralino mass of 16.7 GeV/c2.
In addition, a thorough study of the backgrounds, corrections and systematic uncertainties has been included, indicating that this limit does not exceed 3.5 X 10^(-2) pb when considering the one sigma error on the uncertainty band.
Subjects/Keywords: dark matter;
neutralino;
direct detection;
wimp
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Clark, K. (2009). A New and Improved Spin-Dependent Dark Matter Exclusion Limit Using the PICASSO Experiment
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5323
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Clark, Kenneth. “A New and Improved Spin-Dependent Dark Matter Exclusion Limit Using the PICASSO Experiment
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5323.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Clark, Kenneth. “A New and Improved Spin-Dependent Dark Matter Exclusion Limit Using the PICASSO Experiment
.” 2009. Web. 19 Jan 2019.
Vancouver:
Clark K. A New and Improved Spin-Dependent Dark Matter Exclusion Limit Using the PICASSO Experiment
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5323.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Clark K. A New and Improved Spin-Dependent Dark Matter Exclusion Limit Using the PICASSO Experiment
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/5323
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
14.
Gujral, Taranjit Singh.
The RET receptor tyrosine kinase: mechanism, signaling and therapeutics
.
Degree: Pathology and Molecular Medicine, 2010, Queens University
URL: http://hdl.handle.net/1974/5704
► The RET receptor tyrosine kinase has essential roles in cell survival, differentiation, and proliferation. Oncogenic activation of RET causes the cancer syndrome multiple endocrine neoplasia…
(more)
▼ The RET receptor tyrosine kinase has essential roles in cell survival, differentiation, and proliferation. Oncogenic activation of RET causes the cancer syndrome multiple endocrine neoplasia type 2 (MEN 2), and is a frequent event in sporadic thyroid carcinomas. Multiple endocrine neoplasia 2B (MEN 2B), a subtype of MEN 2, is caused primarily by a methionine to threonine substitution of residue 918 in the kinase domain of the RET receptor (2B-RET), however the molecular mechanisms that lead to the disease phenotype are unclear. In this study, we show that the M918T mutation causes a 10 fold increase in ATP binding affinity, and leads to a more stable receptor-ATP complex, relative to the wildtype receptor. We also show that 2B-RET can dimerize and become autophosphorylated in the absence of ligand. Our data suggest that multiple distinct but complementary molecular mechanisms underlie the MEN 2B phenotype and provide potential targets for effective therapeutics for this disease.
In the second part of the study, we identified a novel β-catenin-RET kinase signaling pathway which is a critical contributor to the development and metastasis of human thyroid carcinoma. We show that RET binds to, and tyrosine phosphorylates, β-catenin and demonstrate that the interaction between RET and β-catenin can be direct and independent of cytoplasmic kinases, such as SRC. As a result of RET-mediated tyrosine phosphorylation, β-catenin escapes cytosolic downregulation by the APC/Axin/GSK3 complex and accumulates in the nucleus, where it can stimulate β-catenin-specific transcriptional programs in a RET-dependent fashion. We show that downregulation of β-catenin activity decreases RET-mediated cell proliferation, colony formation, and tumour growth in nude mice.
Finally, we used a structure guided approach to identify and characterize a novel, non-ATP competitive, RET inhibitor; SW-01. We show that SW-01 provides significant RET inhibition in an in vitro kinase assay using purified RET. Moreover, RET phosphorylation is blocked, or dramatically reduced, in vivo in cells overexpressing active RET. We observe a significant decrease in cell proliferation and colony formation in RET-expressing cells in the presence of SW-01. Together, our data suggest that SW-01 has potential as a novel RET kinase inhibitor with clinical utility.
Subjects/Keywords: RET;
Receptor Tyrosine Kinase;
MEN 2B;
Small molecule inhibitor;
Thyroid Cancer;
Beta-catenin
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gujral, T. S. (2010). The RET receptor tyrosine kinase: mechanism, signaling and therapeutics
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5704
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gujral, Taranjit Singh. “The RET receptor tyrosine kinase: mechanism, signaling and therapeutics
.” 2010. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5704.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gujral, Taranjit Singh. “The RET receptor tyrosine kinase: mechanism, signaling and therapeutics
.” 2010. Web. 19 Jan 2019.
Vancouver:
Gujral TS. The RET receptor tyrosine kinase: mechanism, signaling and therapeutics
. [Internet] [Thesis]. Queens University; 2010. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5704.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gujral TS. The RET receptor tyrosine kinase: mechanism, signaling and therapeutics
. [Thesis]. Queens University; 2010. Available from: http://hdl.handle.net/1974/5704
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
15.
Alim, Ishraq.
ADIPONECTIN MODULATES EXCITABILITY OF SUBFORNICAL ORGAN NEURONS AT DIFFERENT ENERGY STATES
.
Degree: Neuroscience Studies, 2009, Queens University
URL: http://hdl.handle.net/1974/1733
► Adiponectin (ADP) is an adipokine, which acts as an insulin sensitizing hormone. Recent studies have shown that adiponectin receptors (AdipoR1, AdipoR2) are present in the…
(more)
▼ Adiponectin (ADP) is an adipokine, which acts as an insulin sensitizing hormone. Recent studies have shown that adiponectin receptors (AdipoR1, AdipoR2) are present in the CNS; however, there is some debate as to whether or not ADP crosses the blood brain barrier (BBB). Circumventricular organs (CVO) are CNS sites outside the BBB, and thus represent sites at which circulating adiponectin may act to influence the CNS without having to cross the BBB. The subfornical organ (SFO) is a CVO that is responsive to a number of different circulating satiety signals including amylin, CCK, and ghrelin. We report here that the SFO also shows a high density of mRNA for both adiponectin receptors. These observations support the concept that the SFO may be a key player in sensing circulating ADP. To test the hypothesis that ADP influences the excitability of SFO neurons, we used current-clamp electrophysiology on dissociated SFO neurons to observe changes in membrane potential. ADP (10 nM) application effected the excitability of SFO neurons, where the cells either depolarized (8.9±0.9 mV, 21 of 97 cells) or hyperpolarized (-8.0±0.5 mV, 34 of 97 cells). Using single-cell RT-PCR we found that the majority of the responsive neurons expressed AdipoR1 or R2 and the non-responsive neurons expressed neither.
In view of the recognized role of ADP in the regulation of energy balance, we next examined the effects of food deprivation for 48 hours on ADP signaling in the SFO. Our previous microarray analysis of SFO showed increases in AdipoR2 mRNA, with no significant change in AdipoR1 mRNA. We have also assessed the effects of such changes in receptor expression on ADP signaling in SFO neurons using calcium imaging and patch clamp techniques. In SFO neurons obtained from control animals, ADP induced increases in intracellular Ca2+ were observed in 25% of cells, while following food deprivation 0% of cells showed this response. Furthermore, 77% of neurons from starved animals showed clear depolarization, while no hyperpolarizing responses were observed. The results presented in this study suggest that adiponectin modulates the excitability of SFO neurons and that the response to ADP changes during starvation.
Subjects/Keywords: Adiponectin;
Subfornical Organ;
circumventricular organ;
patch clamp;
Energy homeostasis
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APA (6th Edition):
Alim, I. (2009). ADIPONECTIN MODULATES EXCITABILITY OF SUBFORNICAL ORGAN NEURONS AT DIFFERENT ENERGY STATES
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1733
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alim, Ishraq. “ADIPONECTIN MODULATES EXCITABILITY OF SUBFORNICAL ORGAN NEURONS AT DIFFERENT ENERGY STATES
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1733.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alim, Ishraq. “ADIPONECTIN MODULATES EXCITABILITY OF SUBFORNICAL ORGAN NEURONS AT DIFFERENT ENERGY STATES
.” 2009. Web. 19 Jan 2019.
Vancouver:
Alim I. ADIPONECTIN MODULATES EXCITABILITY OF SUBFORNICAL ORGAN NEURONS AT DIFFERENT ENERGY STATES
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1733.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alim I. ADIPONECTIN MODULATES EXCITABILITY OF SUBFORNICAL ORGAN NEURONS AT DIFFERENT ENERGY STATES
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1733
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
16.
Zhang, Xiao.
EVALUATION OF RNA QUALITY FROM FORMALIN FIXED AND PARAFFIN EMBEDDED SAMPLES:APPLICATIONS AND LIMITATIONS
.
Degree: Pathology and Molecular Medicine, 2009, Queens University
URL: http://hdl.handle.net/1974/1740
► RNA molecules isolated from FFPE samples are highly fragmented and modified, and generally deemed unsuitable for downstream gene expression profiling. With the development of molecular…
(more)
▼ RNA molecules isolated from FFPE samples are highly fragmented and modified, and generally deemed unsuitable for downstream gene expression profiling. With the development of molecular biology, there has been growing interest in profiling archival FFPE samples. Successful profiling of transcripts from FFPE samples would greatly expand tissue sources for large scale gene expression studies; also it would pave the way for future applications on the type of tissue readily available in the clinical setting. So far, there is a lack of systemic studies evaluating the quality of RNA isolated from routinely processed FFPE samples, and it has remained difficult to assess how well FFPE-derived RNA mirrors the status of RNA isolated before fixation. In this project, the similarity of miRNA and mRNA profiles between matched frozen and FFPE lymphoid hyperplasia tissues (N=7 for miRNA comparison, N=4 for mRNA comparison) were evaluated. We found consistently good correlation (mean of Pearson coefficient=0.939, mean of Spearman coefficient=0.905, mean of Kendall tau=0.744) between matched frozen and FFPE-derived miRNA profiles, suggesting FFPE samples may retain miRNA expression information quite well. This has major positive implications for research using FFPE samples, as miRNA profiling becomes more prominent in bioprofiling studies. On the contrary, mRNA isolated from FFPE samples showed less correlation (Spearman coefficient less than 0.75) with its frozen counterpart on the Agilent microarray platform. With a post extraction heat treatment aimed at reversing base modifications and cross linking structures, obvious global mRNA quality improvement was observed in cases where samples appeared to be heavily cross linked, but was less effective and even detrimental in cases where cross linking was less prominent. This research suggests that the extent of cross linking may be critical in terms of determining whether a particular FFPE tissue will become a useful source of mRNA for global profiling studies
Subjects/Keywords: FFPE;
miRNA;
mRNA;
heat treatment;
microarray;
profiling
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zhang, X. (2009). EVALUATION OF RNA QUALITY FROM FORMALIN FIXED AND PARAFFIN EMBEDDED SAMPLES:APPLICATIONS AND LIMITATIONS
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1740
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zhang, Xiao. “EVALUATION OF RNA QUALITY FROM FORMALIN FIXED AND PARAFFIN EMBEDDED SAMPLES:APPLICATIONS AND LIMITATIONS
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1740.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zhang, Xiao. “EVALUATION OF RNA QUALITY FROM FORMALIN FIXED AND PARAFFIN EMBEDDED SAMPLES:APPLICATIONS AND LIMITATIONS
.” 2009. Web. 19 Jan 2019.
Vancouver:
Zhang X. EVALUATION OF RNA QUALITY FROM FORMALIN FIXED AND PARAFFIN EMBEDDED SAMPLES:APPLICATIONS AND LIMITATIONS
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1740.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zhang X. EVALUATION OF RNA QUALITY FROM FORMALIN FIXED AND PARAFFIN EMBEDDED SAMPLES:APPLICATIONS AND LIMITATIONS
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1740
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
17.
Héroux, Martin.
The effect of contraction type and intensity, mass loading and visual feedback on wrist tremor in individuals with essential tremor
.
Degree: Rehabilitation Science, 2011, Queens University
URL: http://hdl.handle.net/1974/6894
► Objectives: Determine the effect of contraction type and intensity, inertial loading, and visual feedback on various measures of hand tremor in subjects with essential tremor.…
(more)
▼ Objectives: Determine the effect of contraction type and intensity, inertial loading, and visual feedback on various measures of hand tremor in subjects with essential tremor. Methods: Study 1. Twenty-three ET subjects and 22 controls held their hand in an outstretched position while supporting various submaximal loads (no-load, 5%, 15% and 25% 1-repetition maximum). Hand postural tremor and wrist extensor neuromuscular activity (EMG) were recorded. Study 2. Twenty-one ET subjects and 22 controls applied isometric wrist extension contractions with and without visual feedback. Various submaximal contraction intensities were evaluated (5%, 10%, 20% and 30% MVC). Force production and EMG were recorded. Study 3. Twenty-one ET subjects and 22 healthy controls performed slow wrist extension-flexion movements while supporting various submaximal loads (no-load, 5%, 15% and 25% 1-repetition maximum). Angular displacement and EMG were recorded. Results: Study 1. Inertial loading resulted in a reduction in postural tremor in ET subjects. The largest reduction in tremor amplitude occurred at the 15% load, which was associated with spectral separation of the mechanical reflex and central tremor component. Despite an increase in overall neuromuscular activity with inertial loading, EMG tremor power did not increase with loading. Study 2. Higher contraction intensities were associated with larger amplitude force fluctuations and greater EMG amplitudes. Tremor spectral power of force and EMG remained constant at all target intensities, resulting in a reduction in relative tremor power at higher contraction intensities. Visual feedback affected subjects in the control and ET groups similarly. Study 3. Subjects with more pronounced tremor spectral peaks had larger amplitude kinetic tremor, which was reduced with inertial loading. Despite an increase in overall neuromuscular activity with inertial loading, EMG tremor spectral power was only slightly increased with loading, which resulted in a large reduction in relative EMG tremor power. Conclusions: The effect of inertial loading on postural and kinetic tremor amplitude appears to be mediated in large part by its effect on the interaction between the mechanical reflex and central tremor components. The level of motor unit entrainment remains relatively constant in subjects with ET despite increasing contraction intensities.
Subjects/Keywords: essential tremor;
inertial loading;
electromyography;
coherence;
mechanical reflex;
postural tremor;
force fluctuations
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APA ·
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MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Héroux, M. (2011). The effect of contraction type and intensity, mass loading and visual feedback on wrist tremor in individuals with essential tremor
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6894
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Héroux, Martin. “The effect of contraction type and intensity, mass loading and visual feedback on wrist tremor in individuals with essential tremor
.” 2011. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/6894.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Héroux, Martin. “The effect of contraction type and intensity, mass loading and visual feedback on wrist tremor in individuals with essential tremor
.” 2011. Web. 19 Jan 2019.
Vancouver:
Héroux M. The effect of contraction type and intensity, mass loading and visual feedback on wrist tremor in individuals with essential tremor
. [Internet] [Thesis]. Queens University; 2011. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/6894.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Héroux M. The effect of contraction type and intensity, mass loading and visual feedback on wrist tremor in individuals with essential tremor
. [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6894
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
18.
Tian, Jie.
Integration of Satellite Remote Sensing and Ground-based Measurement for Modelling the Spatiotemporal Distribution of Fine Particulate Matter at a Regional Scale
.
Degree: Geography, 2009, Queens University
URL: http://hdl.handle.net/1974/5320
► Accurate information on the spatial-temporal distributions of air pollution at a regional scale is crucial for effective air quality control, as well as to impact…
(more)
▼ Accurate information on the spatial-temporal distributions of air pollution at a regional scale is crucial for effective air quality control, as well as to impact studies on local climate and public health. The current practice of mapping air quality relies heavily on data from monitoring stations, which are often quite sparse and irregularly spaced. The research presented in this dissertation seeks to advance the methodologies involved in spatiotemporal analysis of air quality that integrates remotely-sensed data and in situ measurement. Aerosol optical depth (AOD) data from the Moderate Resolution Imaging Spectroradiometer (MODIS) is analyzed to estimate fine particulate matter (PM2.5) concentrations as the target air pollutant.
The spatial-temporal distribution of columnar aerosol loading is investigated through mapping MODIS AOD in southern Ontario, Canada throughout 2004. Clear distribution patterns and strong seasonality are found for the study area. There is a detectable relationship between an AOD level and underlying land use structure and topography on the ground. MODIS AOD was correlated with the ground-level PM2.5 concentration (GL-[PM2.5]) at various wavelengths. The AOD-PM2.5 correlation is found to be sensitive to spatial-temporal scale changes. Further, a semi-empirical model has been developed for a more accurate prediction of GL-[PM2.5]. The model employs MODIS AOD data, assimilated meteorological fields, and ground-based meteorological measurements and is able to explain 65% of the variability in GL-[PM2.5]. To achieve a more accurate and informative spatiotemporal modelling of GL-[PM2.5], a method is proposed that integrates the model-predictions and in situ measurements in the framework of Bayesian Maximum Entropy (BME) analysis. A case study of southern Ontario demonstrates the procedures of the method and support for its advantages by comparison with conventional geostatistical approaches. The BME estimation, coupled with BME posterior variance, can be used to depict GL-[PM2.5] distribution in a stochastic context. The methodologies covered in this work are expected to be applicable to the modelling or analysis of other types of air pollutant concentrations.
Subjects/Keywords: Remote Sensing;
Particulate Matter;
Air Quality;
Spatiotemporal Distribution;
Modelling
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APA ·
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CSE |
Export
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Manager
APA (6th Edition):
Tian, J. (2009). Integration of Satellite Remote Sensing and Ground-based Measurement for Modelling the Spatiotemporal Distribution of Fine Particulate Matter at a Regional Scale
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5320
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tian, Jie. “Integration of Satellite Remote Sensing and Ground-based Measurement for Modelling the Spatiotemporal Distribution of Fine Particulate Matter at a Regional Scale
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5320.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tian, Jie. “Integration of Satellite Remote Sensing and Ground-based Measurement for Modelling the Spatiotemporal Distribution of Fine Particulate Matter at a Regional Scale
.” 2009. Web. 19 Jan 2019.
Vancouver:
Tian J. Integration of Satellite Remote Sensing and Ground-based Measurement for Modelling the Spatiotemporal Distribution of Fine Particulate Matter at a Regional Scale
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5320.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tian J. Integration of Satellite Remote Sensing and Ground-based Measurement for Modelling the Spatiotemporal Distribution of Fine Particulate Matter at a Regional Scale
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/5320
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
19.
Gooyers, Chad.
An ergonomic evaluation of Speed Fastening work rates
.
Degree: Kinesiology and Health Studies, 2009, Queens University
URL: http://hdl.handle.net/1974/5113
► Present day manufacturing assembly relies extensively on a variety of fasteners for the assembly of sub-systems, components and trim. Speed Fastening (SF) is one commonly…
(more)
▼ Present day manufacturing assembly relies extensively on a variety of fasteners for the
assembly of sub-systems, components and trim. Speed Fastening (SF) is one commonly used non-structural assembly fastening method. The primary limitation of SF is the lack of continuously fed rivets. One path to productivity improvement for SF is the development of a continuously feed tool that would eliminate the non-value added time currently scheduled for reloading in the work cycle. In preparation for the design of a new tool, a proactive ergonomic investigation was carried out to examine differences in muscular effort, upper-body posture, as well as subjective ratings of perceived exertion and discomfort across three different work rates for a simulated SF task conducted in a laboratory setting. The purpose of this investigation was
to characterize the ergonomic consequences that an increase in work rate would have on SF operators.
Twelve healthy female subjects participated in simulated SF work over four test-sessions.
The first test session familiarized subjects with the SF tasks as well as the data collection protocol. Subsequent test days, which were scheduled 24 hours apart, were block randomized to one of three work rates (7, 14 and 21 fasteners/min.) with subjects required to complete 120 minutes of a simulated SF task at both waist and shoulder height using a 50% work to rest duty
cycle.
The results of this study show significant increases in the amount of muscular activity
required to complete the simulated SF, particularly for the 21 fasteners per minute work rate, with increases in peak sEMG amplitudes ranging from 3-12% MVIC. Specifically these increases were most marked in the forearm extensor muscles. In addition, significantly deviated postures
were found in upper-limb joint ROM data, particularly when SF work was completed at shoulder height.
Overall, based on the increased exposure to risk factors known to be precursors for workplace injury (i.e. repetition and awkward posture), it is inferred that an increase in work rate will put SF operators at an elevated risk of musculoskeletal injury. It is expected that this risk would be even more pronounced for work completed at shoulder height.
Subjects/Keywords: Work Rate; Speed Fastening; Hand Tool; Electromyography; Kinematics; Perceived Exertion
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gooyers, C. (2009). An ergonomic evaluation of Speed Fastening work rates
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5113
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gooyers, Chad. “An ergonomic evaluation of Speed Fastening work rates
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5113.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gooyers, Chad. “An ergonomic evaluation of Speed Fastening work rates
.” 2009. Web. 19 Jan 2019.
Vancouver:
Gooyers C. An ergonomic evaluation of Speed Fastening work rates
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5113.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gooyers C. An ergonomic evaluation of Speed Fastening work rates
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/5113
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
20.
Hum, Maaike.
The effects of small molecule heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2
.
Degree: Pharmacology and Toxicology, 2009, Queens University
URL: http://hdl.handle.net/1974/5321
► Heme oxygenases (HO) catalyze the degradation of heme into biliverdin, carbon monoxide (CO) and free iron. The two major isoforms, HO-2 (constitutive) and HO-1 (inducible…
(more)
▼ Heme oxygenases (HO) catalyze the degradation of heme into biliverdin, carbon monoxide (CO) and free iron. The two major isoforms, HO-2 (constitutive) and HO-1 (inducible by various stressors such as heavy metals and reactive oxygen species) are involved in a variety of physiological functions, including anti-inflammation, antiapoptosis, neuromodulation, and vascular regulation. Major tools used in exploring these actions have been metalloporphyrin analogs of heme that inhibit the HOs. However, these tools are limited by their lack of selectivity; they affect other heme-dependent enzymes, such as cytochromes P450 (CYPs), soluble guanylyl cyclase (sGC), and nitric oxide synthase (NOS). Our laboratory has been able to successfully synthesize a series of small molecule non-porphyrin HO inhibitors (QC-xx) that have had little or no effect against sGC and NOS; however, their effects on various CYP isoforms has yet to be fully elucidated. In order to determine the effects on CYP enzyme activity, microsomal preparations of two CYP isoforms (2E1 and 3A1/3A2) were incubated with varying concentrations of HO inhibitor and the activity was determined via spectrophotometric analysis. Results indicated that some QC compounds demonstrated little to no inhibition of CYP2E1 and/or CYP3A1/2, while some others did inhibit these CYP isoforms. Four regions of interest were analyzed further and several structural changes were identified as conferring increased HO inhibition and decreased effect on both CYP2E1 and 3A1/2. Based on the information obtained, three putative compounds were designed and it is hypothesized that these compounds will be selective inhibitors for HO-1 over HO-2 and will display little effect on either CYP2E1 or 3A1/2 activities.
Subjects/Keywords: Heme oxygenase;
Small molecule inhibitors;
Cytochrome P450 2E1;
Cytochrome P450 3A1/2
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hum, M. (2009). The effects of small molecule heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5321
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hum, Maaike. “The effects of small molecule heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/5321.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hum, Maaike. “The effects of small molecule heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2
.” 2009. Web. 19 Jan 2019.
Vancouver:
Hum M. The effects of small molecule heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/5321.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hum M. The effects of small molecule heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/5321
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
21.
Grunhut, Jason.
Using High-Resolution Spectroscopy To Improve The Determination Of Effective Temperatures OF Pre-Main Sequence Stars
.
Degree: Physics, Engineering Physics and Astronomy, 2009, Queens University
URL: http://hdl.handle.net/1974/1707
► Herbig Ae/Be (HAeBe) stars are the pre-main sequence progenitors of main sequence A and B stars, and are characterized observationally by strong emission in spectral…
(more)
▼ Herbig Ae/Be (HAeBe) stars are the pre-main sequence progenitors of main sequence A and B stars, and are characterized observationally by strong emission in spectral lines and significant infra-red excess that results from their presence in dust-obscured regions. These stars are usually surrounded by a complex environment composed of gas and dust and often a significant stellar wind and a circumstellar disc. This complex circumstellar environment can have a significant affect on their spectral energy distributions, leading to large systematic uncertainties in determinations of their effective temperatures from photometric methods.
In an attempt to improve temperature determinations for HAeBe stars, we have conducted an experiment to evaluate the potential of high-resolution spectra to constrain their atmospheric parameters. To this end, high-resolution (R~68 000) and low-resolution (R~1500) spectra obtained using the ESPaDOnS spectropolarimeter (at the Canada-France-Hawaii telescope) and the FORS1 spectropolarimeter (at the Very Large Telescope) have been used with an automatic spectrum fitting procedure. This procedure compares spectroscopic data to a grid of synthetic LTE, solar abundance spectra, spanning a range in effective temperature, surface gravity, and micro-turbulence.
This analysis was applied to the spectra of a sample of twelve previously well-studied HAeBe stars. Our temperatures were found to be consistent with previously published values, while providing much lower uncertainties - in some cases about 5 times smaller. Numerous methods were investigated to obtain these quantitative uncertainties (chi-squared statistics, Bayesian analysis, Monte Carlo bootstrap method, individual temperature sensitive line region analysis). We conclude that our method can be used to efficiently and effectively obtain temperatures of HAeBe stars in addition to providing us with a characterization of the degree of departure of the spectrum from solar abundance, LTE photospheric models.
Subjects/Keywords: stars;
high-resolution spectroscopy;
pre-main sequence stars;
Herbig stars;
HAeBe stars;
effective temperature
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Grunhut, J. (2009). Using High-Resolution Spectroscopy To Improve The Determination Of Effective Temperatures OF Pre-Main Sequence Stars
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1707
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Grunhut, Jason. “Using High-Resolution Spectroscopy To Improve The Determination Of Effective Temperatures OF Pre-Main Sequence Stars
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1707.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Grunhut, Jason. “Using High-Resolution Spectroscopy To Improve The Determination Of Effective Temperatures OF Pre-Main Sequence Stars
.” 2009. Web. 19 Jan 2019.
Vancouver:
Grunhut J. Using High-Resolution Spectroscopy To Improve The Determination Of Effective Temperatures OF Pre-Main Sequence Stars
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1707.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Grunhut J. Using High-Resolution Spectroscopy To Improve The Determination Of Effective Temperatures OF Pre-Main Sequence Stars
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1707
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
22.
Vatamanu, Mihaela.
Characterization of the Zr-polymeryl Species Present during Ethylene and Propylene Polymerizations by Homogeneous Zirconocene Catalysts
.
Degree: Chemistry, 2015, Queens University
URL: http://hdl.handle.net/1974/12789
► A detailed investigation of Zr-polymeryl intermediates, present during ethylene and propylene polymerization by metallocene and non-metallocene catalysts, is presented. In this regard, the potential use…
(more)
▼ A detailed investigation of Zr-polymeryl intermediates, present during ethylene and propylene polymerization by metallocene and non-metallocene catalysts, is presented. In this regard, the potential use of bromine as a quenching agent to give polymers with brominated end groups is investigated. Using NMR spectroscopy, these groups can be identified as primary or secondary and quantified, thus providing information on the nature of the Zr-polymeryl linkage(s) and their relative concentration(s). Bromine quenching was examined for ethylene polymerization by Cp2ZrMe2/B(C6F5)3, and for propylene polymerization by Cp2ZrMe2/B(C6F5)3, (indenyl)2ZrMe2/B(C6F5)3, and rac-{C2H4(1-indenyl)2}ZrMe2/B(C6F5)3. Polymers with primary alkyl bromide end groups were obtained. In the case of propylene polymerization by [ONNO]Zr(CH2C6H5)2/MAO/2,6-di-tbutylphenol, both primary and secondary alkyl bromide end groups were detected. Primary alkyl bromide end groups result from the cleavage by bromine of primary Zr-CH2~polymeryl linkages while secondary alkyl bromides are the result of the cleavage by bromine of secondary Zr-CH(Me)CH2~polymeryl linkages. The concentration of Zr-CH2~polymeryl intermediates was found to be low, suggesting that the catalyst deactivates during the polymerization.
A second objective of this research is to investigate the formation of Cp2Zr+-allyl complexes as these species are proposed to arise during the polymerization and deactivate the catalyst. Compounds of type [Cp2ZrMe]+ were found to react with vinylidene compounds of type CH2=C(Me)R, (R = CH2CHMe2 and CH2CH(Me)C3H7), to form methane and Cp2Zr+-allyl complexes. The reaction of Cp2ZrMe2/[Ph3C][B(C6F5)4] with CH2=C(Me)CH2CHMe2 involves the unprecedented [Cp2Zr(Me)(CH2CMeCH2CHMe2)]+ intermediate, detected by low temperature one- and two-dimensional NMR spectroscopy. The observation of this intermediate represents the first direct experimental evidence for a d0 metal-alkyl-olefin complex. The dynamic behavior and the kinetics of formation of Cp2Zr+-allyl complexes were also investigated by NMR spectroscopy. In situ propylene polymerization studies indicate that Cp2Zr+-allyl polymeryl intermediates form under catalytic conditions when either Cp2ZrMe2/B(C6F5)3 or Cp2ZrMe2/[Ph3C][B(C6F5)4] are used. Formation of Zr-allyl species occurs in the early stages of the polymerization process, even before the [Cp2ZrMe]+ catalyst is completely consumed, by recoordination of the polypropylene-containing vinylidene end groups, which are the normal products of chain transfer reactions via -H elimination, to the active catalyst.
Subjects/Keywords: olefin polymerization;
propene polymerization;
alkene polymerization;
ethene polymerization;
metallocene catalysts;
nonmetallocene catalysts;
zirconocene;
Ziegler-Natta catalysts;
Zr-polymeryl intermediates;
active species;
dormant species;
mechanism;
metal alkyl;
metal(alkyl)(olefin);
metal allyl;
single-site;
Zr(alkyl)(olefin)
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APA (6th Edition):
Vatamanu, M. (2015). Characterization of the Zr-polymeryl Species Present during Ethylene and Propylene Polymerizations by Homogeneous Zirconocene Catalysts
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/12789
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vatamanu, Mihaela. “Characterization of the Zr-polymeryl Species Present during Ethylene and Propylene Polymerizations by Homogeneous Zirconocene Catalysts
.” 2015. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/12789.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vatamanu, Mihaela. “Characterization of the Zr-polymeryl Species Present during Ethylene and Propylene Polymerizations by Homogeneous Zirconocene Catalysts
.” 2015. Web. 19 Jan 2019.
Vancouver:
Vatamanu M. Characterization of the Zr-polymeryl Species Present during Ethylene and Propylene Polymerizations by Homogeneous Zirconocene Catalysts
. [Internet] [Thesis]. Queens University; 2015. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/12789.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vatamanu M. Characterization of the Zr-polymeryl Species Present during Ethylene and Propylene Polymerizations by Homogeneous Zirconocene Catalysts
. [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/12789
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
23.
Au, Victoria.
CHARACTERIZING THE FUNCTIONAL DOMAINS OF THE BACULOVIRUS LATE EXPRESSION FACTOR 3 (LEF-3) INVOLVED IN NUCLEAR LOCALIZATION AND DNA REPLICATION
.
Degree: Microbiology and Immunology, 2009, Queens University
URL: http://hdl.handle.net/1974/1640
► Transient replication assays have identified a late expression factor 3, LEF-3, to be essential for DNA replication and late gene expression in the baculovirus species,…
(more)
▼ Transient replication assays have identified a late expression factor 3, LEF-3, to be essential for DNA replication and late gene expression in the baculovirus species, AcMNPV. Although its specific role in these two processes has not been determined, this single-stranded DNA binding protein is multi-functional. LEF-3 forms a homo-oligomer, binds single-stranded DNA, interacts with components of the viral replication complex and is required to transport the helicase protein P143 into the nucleus of infected cells. Various regions within LEF-3 were deleted to determine the domain essential to its function and the N-terminal amino acids 1-125 were found to be sufficient for late gene expression. This N-terminal region includes the 56 amino acid region of LEF-3 required for nuclear transport. In order to define this domain, the effect of site-specific mutagenesis of LEF-3 on its intracellular distribution was determined. Fluorescence microscopy of expression plasmid transfected cells demonstrated that amino acids 14 to 37 formed the core nuclear localization signal (NLS), but the flanking amino acids may act as regulatory elements. Comparison with other group 1 Alphabaculoviruses suggested that this core region contained a functionally duplicated NLS. The AcMNPV LEF-3 also functioned in mammalian cells indicating that the protein nuclear import systems in insect and mammalian cells are conserved. Mutagenesis of two conserved cysteine residues located at amino acids 82 and 106 were not essential for nuclear localization or for interaction with P143. However, by using a modified construct of P143 that localized on its own to the nucleus, it was demonstrated that a functional nuclear localization domain on LEF-3 was required for an interaction between LEF-3 and P143.
Subjects/Keywords: Virology;
Baculovirus;
DNA replication
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APA (6th Edition):
Au, V. (2009). CHARACTERIZING THE FUNCTIONAL DOMAINS OF THE BACULOVIRUS LATE EXPRESSION FACTOR 3 (LEF-3) INVOLVED IN NUCLEAR LOCALIZATION AND DNA REPLICATION
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1640
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Au, Victoria. “CHARACTERIZING THE FUNCTIONAL DOMAINS OF THE BACULOVIRUS LATE EXPRESSION FACTOR 3 (LEF-3) INVOLVED IN NUCLEAR LOCALIZATION AND DNA REPLICATION
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1640.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Au, Victoria. “CHARACTERIZING THE FUNCTIONAL DOMAINS OF THE BACULOVIRUS LATE EXPRESSION FACTOR 3 (LEF-3) INVOLVED IN NUCLEAR LOCALIZATION AND DNA REPLICATION
.” 2009. Web. 19 Jan 2019.
Vancouver:
Au V. CHARACTERIZING THE FUNCTIONAL DOMAINS OF THE BACULOVIRUS LATE EXPRESSION FACTOR 3 (LEF-3) INVOLVED IN NUCLEAR LOCALIZATION AND DNA REPLICATION
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1640.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Au V. CHARACTERIZING THE FUNCTIONAL DOMAINS OF THE BACULOVIRUS LATE EXPRESSION FACTOR 3 (LEF-3) INVOLVED IN NUCLEAR LOCALIZATION AND DNA REPLICATION
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1640
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
24.
Everdell, Ian.
The Relationship Between Bottom-Up Saliency and Gaze Behaviour During Audiovisual Speech Perception
.
Degree: Neuroscience Studies, 2009, Queens University
URL: http://hdl.handle.net/1974/1656
► Face-to-face communication is one of the most natural forms of interaction between humans. Speech perception is an important part of this interaction. While speech could…
(more)
▼ Face-to-face communication is one of the most natural forms of interaction between humans. Speech perception is an important part of this interaction. While speech could be said to be primarily auditory in nature, visual information can play a significant role in influencing perception. It is not well understood what visual information is important or how that information is collected. Previous studies have documented the preference to gaze at the eyes, nose, and mouth of the talking face, but physical saliency, i.e., the unique low-level features of the stimulus, has not been explicitly examined. Two eye-tracking experiments are presented to investigate the role of physical saliency in the guidance of gaze fixations during audiovisual speech perception. Experiment 1 quantified the physical saliency of a talking face and examined its relationship with the gaze behaviour of participants performing an audiovisual speech perception task and an emotion judgment task. The majority of fixations were made to locations on the face that exhibited high relative saliency, but not necessarily the maximally salient location. The addition of acoustic background noise resulted in a change in gaze behaviour and a decrease in correspondence between saliency and gaze behaviour, whereas changing the task did not alter this correspondence despite changes in gaze behaviour. Experiment 2 manipulated the visual information available to the viewer by using animated full-feature and point-light talking faces. Removing static information, such as colour, intensity, and orientation, from the stimuli elicited both a change in gaze behaviour and a decrease in correspondence between saliency and gaze behaviour. Removing dynamic information, particularly head motion, resulted in a decrease in correspondence between saliency and gaze behaviour without any change in gaze behaviour. The results of these experiments show that, while physical saliency is correlated with gaze behaviour, it cannot be the single factor determining the selection of gaze fixations. Interactions within and between bottom-up and top-down processing are suggested to guide the selection of gaze fixations during audiovisual speech perception.
Subjects/Keywords: gaze behaviour;
saliency;
speech perception;
eye movements;
bottom-up
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APA ·
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Export
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Manager
APA (6th Edition):
Everdell, I. (2009). The Relationship Between Bottom-Up Saliency and Gaze Behaviour During Audiovisual Speech Perception
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1656
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Everdell, Ian. “The Relationship Between Bottom-Up Saliency and Gaze Behaviour During Audiovisual Speech Perception
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1656.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Everdell, Ian. “The Relationship Between Bottom-Up Saliency and Gaze Behaviour During Audiovisual Speech Perception
.” 2009. Web. 19 Jan 2019.
Vancouver:
Everdell I. The Relationship Between Bottom-Up Saliency and Gaze Behaviour During Audiovisual Speech Perception
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1656.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Everdell I. The Relationship Between Bottom-Up Saliency and Gaze Behaviour During Audiovisual Speech Perception
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1656
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
25.
Kalinovich, Indra K.
Geotextile and Granular Filters for the Remediation of Arctic PCB Contaminated Soils
.
Degree: Civil Engineering, 2016, Queens University
URL: http://hdl.handle.net/1974/13945
► The mobility of contaminants via runoff at sites which require soil excavation as source removal can be controlled through the use of surface permeable reactive…
(more)
▼ The mobility of contaminants via runoff at sites which require soil excavation as source removal can be controlled through the use of surface permeable reactive barriers. This has been accomplished at a remote military site in the Canadian Arctic for soils contaminated with polychlorinated biphenyls (PCBs). The design of these barriers should incorporate criteria for both granular as well as geotextile filters to maximize particle retention, without hindering hydraulic performance and with the consideration for adsorption/reaction mechanisms. Field observations and laboratory testing in the form of batch and column tests were conducted to evaluate design criteria, filter performance and mechanisms of PCB retention. The initial barrier prototype was constructed on site in July of 2003. Modifications were required to improve hydraulic performance in the barrier and maximize sedimentation processes in the field. These modifications resulted in an increase to funnel area, constructed flow impediments, and more permeable materials in the gate. Two additional barrier systems were constructed in August of 2005. Subsequent field and laboratory work demonstrated that granular materials trapped the majority of PCB-contaminated soil without impeding hydraulic performance; however, fines were escaping. Extensive column testing in the laboratory has shown that a nonwoven geotextile filter can be applied with success with a granular permeable reactive barrier system. Batch and column testing indicated that particle retention was the most important factor in trapping PCBs in the filter system. However, field sample results indicated that up to 62 ± 11% percent of PCB by mass was being partitioned on to the GAC (Granular Activated Carbon), a mechanism that was being inadequately captured by traditional batch and column tests. Cold temperature laboratory tests (2-4 °C) demonstrated that the presence of water had no effect on PCB adsorption to GAC and that particle-particle partitioning was affected by temperature. Cold temperature column tests indicated that the primary mechanism of PCB transfer in the barrier system was via particle-particle partitioning. The sequestration of PCBs in a permeable reactive barrier has important implications for both surface and subsurface remediation.
Subjects/Keywords: polychlorinated biphenyls;
remediation;
cold regions;
permeable reactive barrier;
Canadian Arctic
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MLA ·
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CSE |
Export
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APA (6th Edition):
Kalinovich, I. K. (2016). Geotextile and Granular Filters for the Remediation of Arctic PCB Contaminated Soils
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/13945
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kalinovich, Indra K. “Geotextile and Granular Filters for the Remediation of Arctic PCB Contaminated Soils
.” 2016. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/13945.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kalinovich, Indra K. “Geotextile and Granular Filters for the Remediation of Arctic PCB Contaminated Soils
.” 2016. Web. 19 Jan 2019.
Vancouver:
Kalinovich IK. Geotextile and Granular Filters for the Remediation of Arctic PCB Contaminated Soils
. [Internet] [Thesis]. Queens University; 2016. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/13945.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kalinovich IK. Geotextile and Granular Filters for the Remediation of Arctic PCB Contaminated Soils
. [Thesis]. Queens University; 2016. Available from: http://hdl.handle.net/1974/13945
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
26.
Wu, Wei.
Mechanistic Studies of Radical-mediated Polyolefin Modifications
.
Degree: Chemical Engineering, 2009, Queens University
URL: http://hdl.handle.net/1974/1655
► The free radical addition of saturated polymers and small molecules to unsaturated monomers is used to prepare functional derivatives under solvent-free, reactive extrusion conditions. Of…
(more)
▼ The free radical addition of saturated polymers and small molecules to unsaturated monomers is used to prepare functional derivatives under solvent-free, reactive extrusion conditions. Of particular interest are the dynamics and yields of conventional peroxide-initiated grafting of vinyltrialkoxysilanes to polyethylene, as well as the mechanisms through which bicumene initiates the process at high temperatures. Knowledge of these commercial processes is applied toward the development of new graft modification technology, including radical initiated polymer addition to alkynes, and a new variation of precipitation polymerization chemistry.
The thermolysis of bicumene at temperatures ranging from 220°C to 270°C was used to initiate C-H bond addition from alkanes to vinylsilanes in a high-temperature analogue of conventional grafting practice. The initiation mechanism is shown to involve direct hydrogen atom abstraction by intermediate cumyl radicals, as well as autooxidation processes involving cumyl radicals and available oxygen.
Conventional peroxide initiated graft modifications of polyethylene with vinylsilanes are examined from the standpoint of reaction dynamics and yields. The influence of peroxide loading and monomer concentration on these reaction variables can be described using a simple quasi-steady state kinetic analysis, while the unusual insensitivity of reaction yields to temperature requires further investigation.
A new chemical modification of saturated polymers involving free radical addition to mono-substituted alkynes is presented and examined in terms of reaction yield, graft structure, and changes to molecular weight. Model compounds are used to characterize alkyne grafting products, and to probe the relationship between reagent properties, reaction yields, and product structures.
The discovery of cross-linked particles in the products of polypropylene graft modifications with triallyltrimesate has led to a variation of precipitation polymerization wherein C-H bond addition to an allyl monomer contributes to molecular weight growth, thereby incorporating a significant amount of saturated hydrocarbon into the solid phase. The relationships between reaction conditions and solid-phase composition and morphology are discussed.
Subjects/Keywords: radical-mediated;
polymer modification
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wu, W. (2009). Mechanistic Studies of Radical-mediated Polyolefin Modifications
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1655
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wu, Wei. “Mechanistic Studies of Radical-mediated Polyolefin Modifications
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1655.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wu, Wei. “Mechanistic Studies of Radical-mediated Polyolefin Modifications
.” 2009. Web. 19 Jan 2019.
Vancouver:
Wu W. Mechanistic Studies of Radical-mediated Polyolefin Modifications
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1655.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wu W. Mechanistic Studies of Radical-mediated Polyolefin Modifications
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1655
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
27.
Dai, Wen Hong.
On the Simulation and Prediction of Bed Morphological Adjustments of Equilibrium in Alluvial Meandering Streams
.
Degree: Civil Engineering, 2009, Queens University
URL: http://hdl.handle.net/1974/1639
► This thesis concerns the computation of bed adjustments of equilibrium in alluvial meandering streams. It is assumed that the channel centerlines follow sine-generated curves, the…
(more)
▼ This thesis concerns the computation of bed adjustments of equilibrium in alluvial meandering streams. It is assumed that the channel centerlines follow sine-generated curves, the banks are rigid, and the steady-state flow is turbulent and sub-critical. The flow width is assumed to remain constant in the streamwise direction, and the flow width-to-depth ratio is large (>=15, say). The bed material is cohesionless and homogeneous.
The purpose of the thesis is to develop and test a numerical model for the computation of bed development, given the aforementioned idealized conditions. The model comprises: 1- an initial bed topography generator, to generate the bed at time t = 0 of the calculations; 2- the vertically-averaged hydrodynamic model of Zhang (2007) to calculate the flow fields; and 3- a sediment transport model to relate the bed deformation to the flow. Both the initial bed topography generator (expression of the deformed bed surface) and the numerical sediment transport model based on the sediment transport continuity equation are original and developed entirely by the author. The resulting model is computationally very efficient. In contrast to previous works on the theoretical determination of bed deformation, the beds at the beginning of the calculations may represent any stage of the development process, and not necessarily the initial flat bed.
The bed deformation was tested for several test cases, devised on the basis of laboratory runs available in the literature. These include Run ME-2 by Hasegawa (1983) in a 30-degree-channel, Run 3 by Binns (2006) in a 70-degree-channel and the run by Termini (1996) in a 110-degree-channel.
The erosion/deposition patterns of the computed equilibrium bed topographies were found to be in reasonable agreement with their measured counterparts. However, as evidenced by the difference plots included in this thesis, in detail there are substantial differences between the computed and measured equilibrium beds, especially in the regions near the banks.
As a by-product of the present thesis, the functions representing the parameters required by the hydrodynamic model of Zhang (2007) were also evaluated. In particular, the present results suggest that the coefficient Alpha-q appearing in the expression of the local friction factor (used in the flow model of Zhang 2007) depends on the flow width-to-depth ratio and bed roughness to a much larger extent than previously thought. Considering this, a generalization of the expression of Alpha-q due to El-Tahawy (2004) (and adopted by Zhang 2007 in her model) is proposed.
Future work should be carried out to address the application of the present model to real river conditions, including generalizations to irregular meandering plan shapes, unsteady-state flows and non-homogenous bed materials.
Subjects/Keywords: Numerical Modeling;
Meandering Stream;
Bed Adjustment;
Equilibrium State;
Geometry Model;
Sediment Transport Model
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dai, W. H. (2009). On the Simulation and Prediction of Bed Morphological Adjustments of Equilibrium in Alluvial Meandering Streams
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1639
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Dai, Wen Hong. “On the Simulation and Prediction of Bed Morphological Adjustments of Equilibrium in Alluvial Meandering Streams
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1639.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Dai, Wen Hong. “On the Simulation and Prediction of Bed Morphological Adjustments of Equilibrium in Alluvial Meandering Streams
.” 2009. Web. 19 Jan 2019.
Vancouver:
Dai WH. On the Simulation and Prediction of Bed Morphological Adjustments of Equilibrium in Alluvial Meandering Streams
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1639.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Dai WH. On the Simulation and Prediction of Bed Morphological Adjustments of Equilibrium in Alluvial Meandering Streams
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1639
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
28.
Muller, Kathryn V.
Holding Hands With Wampum: Haudenosaunee Council Fires from the Great Law of Peace to Contemporary Relationships with the Canadian State
.
Degree: History, 2009, Queens University
URL: http://hdl.handle.net/1974/1643
► “Holding Hands With Wampum” weaves a story of disparate peoples who came together to create a new North American World over a period of more…
(more)
▼ “Holding Hands With Wampum” weaves a story of disparate peoples who came together to create a new North American World over a period of more than five centuries. The Mohawk, Oneida, Onondaga, Cayuga, Seneca, and Tuscarora member nations of the Haudenosaunee Confederacy conceptualized their universe according to the kaswentha ethic and above all treasured autonomy on local, national, and confederate scales. “Holding Hands With Wampum” traces the spiritual foundations of this Haudenosaunee worldview and then uses ethical discourse to explain the evolution of Haudenosaunee-European relationships through the seventeenth and eighteenth centuries to Canadian Confederation and, finally, to the modern age of land reclamations and assertions of Haudenosaunee sovereignty. Unravelling a uniquely Haudenosaunee perspective of the past, “Holding Hands With Wampum” is a cultural form of intellectual history, as it employs Haudenosaunee culture and ethical discourse to understand the place of a diverse community in the very public world of council fires and other political interactions. As an exercise in ethnohistory, “Holding Hands With Wampum” combines the documentary record with wampum belts and oral interviews in an effort to create a balanced historical narrative that situates culture in a constantly changing geo-political reality. The concept of métissage also provides a framework for understanding how these dramatically different peoples came together in the eighteenth century and created a new, common diplomatic protocol. Only by shedding light upon Haudenosaunee-European relations over such a long period can we hope to understand contemporary issues of land and treaty rights and, perhaps, learn how to rekindle the métissage of a not so distant past.
Subjects/Keywords: Iroquois;
Haudenosaunee;
wampum;
Covenant Chain alliance;
Great Law of Peace;
Aboriginal-Canadian relations
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Muller, K. V. (2009). Holding Hands With Wampum: Haudenosaunee Council Fires from the Great Law of Peace to Contemporary Relationships with the Canadian State
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1643
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Muller, Kathryn V. “Holding Hands With Wampum: Haudenosaunee Council Fires from the Great Law of Peace to Contemporary Relationships with the Canadian State
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1643.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Muller, Kathryn V. “Holding Hands With Wampum: Haudenosaunee Council Fires from the Great Law of Peace to Contemporary Relationships with the Canadian State
.” 2009. Web. 19 Jan 2019.
Vancouver:
Muller KV. Holding Hands With Wampum: Haudenosaunee Council Fires from the Great Law of Peace to Contemporary Relationships with the Canadian State
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1643.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Muller KV. Holding Hands With Wampum: Haudenosaunee Council Fires from the Great Law of Peace to Contemporary Relationships with the Canadian State
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1643
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
29.
DeSisto, Stephanie.
Dynamic Arsenic Cycling in Scorodite-Bearing Hardpan Cements, Montague Gold Mines, Nova Scotia
.
Degree: Geological Sciences and Geological Engineering, 2009, Queens University
URL: http://hdl.handle.net/1974/1641
► Hardpans, or cemented layers, form from precipitation and subsequent cementation of secondary minerals in mine tailings and can act as both physical and chemical barriers.…
(more)
▼ Hardpans, or cemented layers, form from precipitation and subsequent cementation of secondary minerals in mine tailings and can act as both physical and chemical barriers. During precipitation, metals in the tailings are sequestered, making hardpan a potentially viable method of natural attenuation. At Montague Gold Mines, Nova Scotia, tailings are partially cemented by the iron (Fe) arsenate mineral scorodite (FeAsO4•2H2O). Scorodite is known as a phase that can effectively limit aqueous arsenic (As) concentrations due to its relatively low solubility (<1 ppm, pH 5) and high As content (~30 wt.%). However, scorodite will not lower As concentrations from waters to below the Canadian drinking water guideline (0.010 ppm).
To identify current field conditions influencing scorodite precipitation and dissolution and to better understand the mineralogical and chemical relationship between hardpan and tailings, coexisting waters and solids were sampled to provide information on tailings-water interactions. Hardpan cement compositions were found to include Fe arsenate and Fe oxyhydroxide in addition to scorodite. End-member pore water chemistry was identified based on pH and dissolved concentration extremes (e.g. pH 3.78, As(aq) 35.8 ppm) compared to most other samples (avg. pH 6.41, As(aq) 2.07 ppm). These end-member characteristics coincide with the most extensive and dispersed areas of hardpan.
Nearly all hardpan is associated with historical arsenopyrite-bearing concentrate which provides a source of acidity and dissolved As+5 and Fe+3 for scorodite precipitation. A proposed model of progressive arsenopyrite oxidation suggests localized As cycling involving scorodite is occurring but is dependent on sulfide persistence. Therefore, permanent As sequestration is not expected. Remediation efforts would have to consider the possibility of scorodite dissolution after complete sulfide consumption or as a consequence of applying certain technologies, such as a cover. Conversely, if scorodite stability were maintained, the hardpan could be considered as a component in remediating the tailings at Montague.
Subjects/Keywords: Arsenic;
Hardpan;
Scorodite;
Montague Gold Mines, Nova Scotia
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APA (6th Edition):
DeSisto, S. (2009). Dynamic Arsenic Cycling in Scorodite-Bearing Hardpan Cements, Montague Gold Mines, Nova Scotia
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1641
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
DeSisto, Stephanie. “Dynamic Arsenic Cycling in Scorodite-Bearing Hardpan Cements, Montague Gold Mines, Nova Scotia
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1641.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
DeSisto, Stephanie. “Dynamic Arsenic Cycling in Scorodite-Bearing Hardpan Cements, Montague Gold Mines, Nova Scotia
.” 2009. Web. 19 Jan 2019.
Vancouver:
DeSisto S. Dynamic Arsenic Cycling in Scorodite-Bearing Hardpan Cements, Montague Gold Mines, Nova Scotia
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1641.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
DeSisto S. Dynamic Arsenic Cycling in Scorodite-Bearing Hardpan Cements, Montague Gold Mines, Nova Scotia
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1641
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
30.
Caesar, S. Mary.
Gender, Politics and Social Medicine in South Africa, 1940 - 1959
.
Degree: History, 2009, Queens University
URL: http://hdl.handle.net/1974/1653
► This thesis is a first step to a gender analysis of South Africa’s social medicine experiment of the 1940s. The research focused on the work…
(more)
▼ This thesis is a first step to a gender analysis of South Africa’s social medicine experiment of the 1940s. The research focused on the work of the Health Centres, in particular Grassy Park and Polela, which were established in South Africa between 1940 and 1959, i.e., the date when all Health Centres were either closed down or converted into ordinary outpatient clinics for the Provincial Hospitals. It is based on an examination of archival records such as the reports of the Health Centres, in, and the official records prepared by the then Department of Public Health and the Medical Officers-in-Charge of the Health Centres. In order to undertake a gender analysis, I asked two main questions: how Health Centre Practice (HCP), i.e. discourse and work of the Health Centres, responded to gender roles and relations it encountered in the community where it operated and secondly, how HCP advocates constructed a particular discourse about black people’s health that effectively depoliticized health, poverty and the role of the state in the creation and maintenance of disease and poverty. There is sufficient evidence to show that the Health Centres provided a valuable service to black women at a time when the state did not prioritize black people’s health, however, the historical moment within which HCP was conceived and implemented, implies that neither the project nor its implementers could escape the dominant racist, patriarchal political values.
Subjects/Keywords: Social Medicine;
Politics;
Gender;
South Africa
Record Details
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Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Caesar, S. M. (2009). Gender, Politics and Social Medicine in South Africa, 1940 - 1959
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/1653
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Caesar, S Mary. “Gender, Politics and Social Medicine in South Africa, 1940 - 1959
.” 2009. Thesis, Queens University. Accessed January 19, 2019.
http://hdl.handle.net/1974/1653.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Caesar, S Mary. “Gender, Politics and Social Medicine in South Africa, 1940 - 1959
.” 2009. Web. 19 Jan 2019.
Vancouver:
Caesar SM. Gender, Politics and Social Medicine in South Africa, 1940 - 1959
. [Internet] [Thesis]. Queens University; 2009. [cited 2019 Jan 19].
Available from: http://hdl.handle.net/1974/1653.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Caesar SM. Gender, Politics and Social Medicine in South Africa, 1940 - 1959
. [Thesis]. Queens University; 2009. Available from: http://hdl.handle.net/1974/1653
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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