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You searched for id:"oai:scholarworks.gsu.edu:biology_theses-1101". One record found.

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Georgia State University

1. Arrowood, Colin. GABAergic Inhibition of Brainstem Neurons Involved in Breathing Regulation is Disrupted in Rett Syndrome.

Degree: MS, Biology, 2019, Georgia State University

GABA is the prominent inhibitory neurotransmitter in the brain and defects in the GABA system are attributable to several genetic diseases including Rett Syndrome (RTT). People with RTT show characteristic breathing disorders, suggesting a link with defects in the GABA system. Noradrenergic neurons in the locus coeruleus (LC) are CO2 chemosensitive and play a role in breathing regulation. We conducted experiments to find out if activation of a novel group of dorsomedial LC GABAergic neurons causes instantaneous firing rate changes in LC neurons. Spike train recordings with cross-correlation analysis suggests that the dmLC neurons made monosynaptic and oligosynaptic connections with the LC neurons. The GABAergic inhibition appeared to have major effects on medullary respiratory neurons, as our results showed that THIP, the extrasynaptic GABA receptor agonist, suppressed excitations in these cells. The results from these experiments provide new evidence for the GABAergic inhibition of brainstem neurons involved in breathing control. Advisors/Committee Members: Dr. Chun Jiang, Dr. Vincent Rehder, Dr. Kyle Frantz.

Subjects/Keywords: Locus coeruleus; Optogenetics; Rett Syndrome; MEA; Microelectrode Array; Transgenic; In-vitro

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APA (6th Edition):

Arrowood, C. (2019). GABAergic Inhibition of Brainstem Neurons Involved in Breathing Regulation is Disrupted in Rett Syndrome. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/biology_theses/95

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Arrowood, Colin. “GABAergic Inhibition of Brainstem Neurons Involved in Breathing Regulation is Disrupted in Rett Syndrome.” 2019. Thesis, Georgia State University. Accessed August 24, 2019. https://scholarworks.gsu.edu/biology_theses/95.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Arrowood, Colin. “GABAergic Inhibition of Brainstem Neurons Involved in Breathing Regulation is Disrupted in Rett Syndrome.” 2019. Web. 24 Aug 2019.

Vancouver:

Arrowood C. GABAergic Inhibition of Brainstem Neurons Involved in Breathing Regulation is Disrupted in Rett Syndrome. [Internet] [Thesis]. Georgia State University; 2019. [cited 2019 Aug 24]. Available from: https://scholarworks.gsu.edu/biology_theses/95.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arrowood C. GABAergic Inhibition of Brainstem Neurons Involved in Breathing Regulation is Disrupted in Rett Syndrome. [Thesis]. Georgia State University; 2019. Available from: https://scholarworks.gsu.edu/biology_theses/95

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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