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1. Trautmann, Sebastian. The consequences of traumatic stress for the development and treatment of mental disorders:
Investigating moderating factors.

Degree: Fakultät Mathematik und Naturwissenschaften, 2019, Technische Universität Dresden

Background: Per definition, traumatic events include exposures to death, threatened death, actual or threatened serious injury, or actual or threatened sexual violence. Exposure to traumatic events is associated with persistent alterations in biological and psychological processes that are involved in the etiology of mental disorders. In fact, traumatic events are associated with a higher risk for various mental disorders such as posttraumatic stress disorder (PTSD) and substance use disorders, but also with treatment resistance. Thus, it is crucial to develop early interventions to prevent these adverse trauma-related outcomes. However, existing pharmacological and psychological early intervenions only have a limited efficacy so far. A major reason is that only a minority of trauma-exposed individuals actually develops adverse consequences making universally applied interventions ineffective. Thus, it is crucial to identify moderators of adverse responses to trauma exposure. Aims: This thesis aimed at (1) providing estimates on the prevelance of traumatic event exposure and trauma-related mental disorders for the general population and high-risk populations and (2) investigating moderators of adverse mental health consequences following traumatic event exposure. The following potential moderators were investigated: (i) the susceptibility to others‘ emotions, (ii) childhood traumas, (iii) biological stress markers and (iv) a specific genetic polymorphism involved in the degradation of monoamines (i.e. MAOA gene). These investigations were conducted with respect to differenct outcomes relevant in the processing of traumatic events including the initial affective and biological reaction, mental disorder symptoms (focusing on PTSD and alcohol use symptoms) and treatment response. Methods: To answer the research questions, different methods and designs were applied. First, epidemiological data from a national study program in German soldiers deployed to Afghanistan were used. These data included diagnostic interview data as well as biological markers. Second, an experimental study with a randomized trauma analogue design was used to investigate moderators of acute trauma responses. Third, a genetic moderator of trauma effects on treatment response was investigated using data from a multi-center trial of exposure-based cognitive behavioral therapy of panic and agoraphobia patients. Main results: Only a small minority of trauma-exposed individuals develops mental disorders. This also applies to populations with a high risk for multiple and/or severe trauma exposure. The investigations of potential moderators suggeted that individuals with a higher susceptibility to negative emotions of others show a higher stress reactivity after trauma exposure. Males with childhood traumas show a higher increase in alcohol craving after trauma exposure. Moreover, individuals with lower basal cortisol levels have a higher risk of increased PTSD symptoms and alcohol use following trauma exposure. Finally, a subgroup of traumatized female…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Trautmann, S. (2019). The consequences of traumatic stress for the development and treatment of mental disorders:
Investigating moderating factors. (Thesis). Technische Universität Dresden. Retrieved from http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa2-349173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Trautmann, Sebastian. “The consequences of traumatic stress for the development and treatment of mental disorders:
Investigating moderating factors.” 2019. Thesis, Technische Universität Dresden. Accessed August 24, 2019. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa2-349173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Trautmann, Sebastian. “The consequences of traumatic stress for the development and treatment of mental disorders:
Investigating moderating factors.” 2019. Web. 24 Aug 2019.

Vancouver:

Trautmann S. The consequences of traumatic stress for the development and treatment of mental disorders:
Investigating moderating factors. [Internet] [Thesis]. Technische Universität Dresden; 2019. [cited 2019 Aug 24]. Available from: http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa2-349173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Trautmann S. The consequences of traumatic stress for the development and treatment of mental disorders:
Investigating moderating factors. [Thesis]. Technische Universität Dresden; 2019. Available from: http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa2-349173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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