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University of Oulu

1. Uimari, O. (Outi). Epidemiological and familial risk factors of uterine leiomyoma development.

Degree: 2017, University of Oulu

Abstract Uterine leiomyomas are the most common benign tumours in females. They are myometrial neoplasms, may present single or multiple, and may be located in various sites of the uterus. Leiomyomas distort the uterine cavity and the uterus itself, causing abnormal vaginal bleeding, reduced fertility and also pelvic pressure and pain symptoms. The aim of this study was to elaborate current knowledge on familial uterine leiomyomas and to explore the possible association between uterine leiomyoma and cardiovascular disease risk factors, and also the association between leiomyomas and endometriosis. The natural history of familial uterine leiomyoma study showed significant differences between familial and non-familial leiomyoma cases, familial cases having more severe clinical characteristics. They presented with multiple uterine leiomyomas and were more often symptomatic. They were also diagnosed at a younger age. The prevalence study on uterine leiomyomas and endometriosis offered confirmation of an association between the diseases. Uterine leiomyomas and endometriosis seem to decrease female fertility independently of each other. Uterine leiomyomas related to the hereditary leiomyomatosis and renal cell cancer (HLRCC) tumour syndrome were studied in regard to their clinical characteristics and immunophenotype. The study provided evidence that women with HLRCC may be identified through distinct leiomyoma clinical characteristics, and routine-use IHC of CD34 and Bcl-2. Distinguishing these leiomyoma cases from sporadic ones may identify families affected by fumarate hydratase (fumarase, FH) mutation. Uterine leiomyoma and cardiovascular disease risk factors were studied in The Northern Finland Birth Cohort 1966 (NFBC1966). The study showed an association between leiomyomas and raised cardiovascular disease risk factors, serum lipids and metabolic syndrome in particular. These findings may suggest that there are shared predisposing factors underlying both uterine leiomyomas and adverse metabolic and cardiac disease risks, or that metabolic factors have a role in biological mechanisms underlying leiomyoma development. This study provides novel information on clinical characteristics of familial uterine leiomyomas and on the immunophenotype of HLRCC-related leiomyomas. The study also offers significant confirmation of associations between uterine leiomyomas and both endometriosis and several CVD risk factors.

Tiivistelmä Kohdun leiomyoomat ovat naisten yleisin hyvänlaatuinen kasvain. Ne ovat myometriumin neoplastisia muutoksia ja ne ilmenevät joko yksittäisinä tai monilukuisina, ja ne voivat sijaita missä tahansa kohdun myometriumia. Leiomyoomat muuttavat kohdun ja kohtuontelon säännöllistä muotoa. Lisäksi ne aiheuttavat vuotohäiriöitä, alentunutta hedelmällisyyttä, ja lantion alueen painetta ja kipua. Tämän tutkimuksen tavoitteena oli laajentaa nykyistä tietämystä suvuittain esiintyvistä kohdun leiomyoomista ja selvittää mahdollista leiomyoomien ja kardiovaskulaaritautiriskin assosiaatiota, ja lisäksi selvittää…

Advisors/Committee Members: Ryynänen, M. (Markku), Järvelä, I. (Ilkka).

Subjects/Keywords: cardiovascular risk; endometriosis; epidemiology; familial; glucose metabolism; lipid metabolism; natural history; population-based birth cohort studies; subfertility; uterine leiomyoma/fibroids; alentunut hedelmällisyys; endometrioosi; epidemiologia; familiaalinen; glukoosimetabolia; kardiovaskulaaririski; kohdun leiomyooma; lipidimetabolia; taudinkulku; väestopohjaiset syntymäkohorttitutkimukset; Bcl-2; CD34; FH; HLRCC

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APA (6th Edition):

Uimari, O. (. (2017). Epidemiological and familial risk factors of uterine leiomyoma development. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789526214870

Chicago Manual of Style (16th Edition):

Uimari, O (Outi). “Epidemiological and familial risk factors of uterine leiomyoma development.” 2017. Doctoral Dissertation, University of Oulu. Accessed September 24, 2017. http://urn.fi/urn:isbn:9789526214870.

MLA Handbook (7th Edition):

Uimari, O (Outi). “Epidemiological and familial risk factors of uterine leiomyoma development.” 2017. Web. 24 Sep 2017.

Vancouver:

Uimari O(. Epidemiological and familial risk factors of uterine leiomyoma development. [Internet] [Doctoral dissertation]. University of Oulu; 2017. [cited 2017 Sep 24]. Available from: http://urn.fi/urn:isbn:9789526214870.

Council of Science Editors:

Uimari O(. Epidemiological and familial risk factors of uterine leiomyoma development. [Doctoral Dissertation]. University of Oulu; 2017. Available from: http://urn.fi/urn:isbn:9789526214870

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